Disease table of HYPERINSULINEMIA HYPOGLYCEMIA OMIM ID: PS256450

Gene-disease associations table

GeneAssociated with HYPERINSULINEMIA HYPOGLYCEMIA inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
HADHClinVar, OMIM, HUMSAVARHGNC link4q252PS256450, 231530
KCNJ11ClinVar, OMIM, HUMSAVARHGNC link11p15.15610582, 606176, 616329, PS256450, 125853
SLC16A1ClinVar, OMIMHGNC link1p13.23616095, 245340, PS256450
GCKClinVar, OMIM, HUMSAVARHGNC link7p134125851, PS256450, 606176, 125853
GLUD1ClinVar, OMIM, HUMSAVARHGNC link10q23.21PS256450
INSRClinVar, OMIM, HUMSAVARHGNC link19p13.25610549, 125853, PS256450, 246200, 262190
ABCC8ClinVar, OMIM, HUMSAVARHGNC link11p15.15240800, 610374, 606176, PS256450, 125853

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
11p15.12ABCC8, KCNJ11
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
11p152ABCC8, KCNJ11
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
11p12ABCC8, KCNJ11
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
11p2ABCC8, KCNJ11
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
112ABCC8, KCNJ11
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
HNF4ANO43GPR39, TBP, CYP2C9, CEACAM1, KCNJ11, LDLR, SHBG, APOA1, UGT2B7, MMP7, CYP7A1, HNF1A, ABCC6, SERPINC1, GH1, PCSK9, CYP2B6, NR1I2, CYP2D6, ABCG8, PPARA, APOB, ABCG5, CDKN1A, AFP, CYP27A1, ACMSD, SLC26A3, RNASE2, SLC22A6, UGT1A7, AKR1C4, GCK, NPC1L1, C1QTNF5, APOA2, APOC3, ACAT2, CYP2C8, FABP2, GFER, MYC, LIPC2KCNJ11, GCK
USF1NO58PF4, FCER1A, CEACAM5, FMO3, ID4, SCN9A, ASCL2, CEACAM1, MYH9, AGT, APOA2, SERPINE1, TBX21, TOP3A, PTGS2, CYP19A1, ISG20, GCK, CTSB, CXCR4, EXT1, TCN2, SLC22A2, TGFB1, PKLR, FMR1, SLC19A1, APC, SLC16A1, TYMS, CCNB1, TGFB2, PIGR, CYP1A1, CTSD, HOXB7, TRAP, IFNG, PTPN6, NPHS2, GATA5, FBP1, S100A6, BRCA2, HOXB4, ABCA1, SERBP1, TERT, ASPH, APOA5, B2M, HMOX1, CD2, CIITA, APEX1, PTGDS, SLC1A3, LIPC2SLC16A1, GCK
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
KCNJ11YES1HNF4A0
SLC16A1YES1USF10
GCKYES5HNF4A, HIF1A, PDX1, PAX6, USF10
INSRYES5CEBPB, SP1, HMGA1, ESR2, CEBPA0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
HADHSLC16A1No1NTRK1
HADHGLUD1No1NTRK1
HADHINSRNo2NTRK1, MAPK3
KCNJ11ABCC8Yes0
SLC16A1GLUD1No5UNK, ILK, BMPR1A, NTRK1, CUL3
SLC16A1INSRNo1NTRK1
GLUD1INSRNo2NTRK1, STAT5A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
HADHKCNJ11No-1FOXA2
HADHSLC16A1No-1UBC
HADHGCKNo-1FOXA2
HADHGLUD1No-1UBC
HADHINSRNo-1UBC
HADHABCC8No-1FOXA2
KCNJ11GCKNo-1FOXA2
KCNJ11INSRNo-1HSP90AA1
KCNJ11ABCC8Yesbinding8RAPGEF4, HSP90AA1, PRKACG, FOXA2, RAPGEF3, PRKACA, KCNJ8, PRKACB
SLC16A1GLUD1No-1UBC
SLC16A1INSRNo-1UBC
GCKINSRNo-2INS, INPPL1
GCKABCC8No-2INS, FOXA2
GLUD1INSRNo-1UBC
INSRABCC8No-2INS, HSP90AA1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Type II diabetes mellitushsa049307.124KCNJ11, INSR, ABCC8, GCK
Metabolic pathwayshsa011002.493HADH, GLUD1, GCK
Insulin secretionhsa049116.183KCNJ11, GCK, ABCC8
Insulin signaling pathwayhsa049105.552GCK, INSR

NET-GE enrichment

Term New enriched termICP valueGenes
Endocrine and metabolic diseasesNEW4.750.002KCNJ11, INSR, ABCC8, GCK
Insulin secretion (hsa04911) -6.180.003KCNJ11, GCK, ABCC8
Type II diabetes mellitus (hsa04930) -7.120.0KCNJ11, INSR, ABCC8, GCK
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
MetabolismR-HSA-14307282.346SLC16A1, GCK, ABCC8, KCNJ11, GLUD1, HADH
Transmembrane transport of small moleculesR-HSA-3825513.794SLC16A1, KCNJ11, ABCC8, GCK
Inwardly rectifying K+ channelsR-HSA-12960658.032KCNJ11, ABCC8
Regulation of insulin secretionR-HSA-4223566.662KCNJ11, ABCC8
Potassium ChannelsR-HSA-12960716.352KCNJ11, ABCC8
ABC-family proteins mediated transportR-HSA-3825567.592KCNJ11, ABCC8
Integration of energy metabolismR-HSA-1636856.242KCNJ11, ABCC8
SLC-mediated transmembrane transportR-HSA-4254074.952SLC16A1, GCK
Neuronal SystemR-HSA-1123164.822KCNJ11, ABCC8
ATP sensitive Potassium channelsR-HSA-129602510.982KCNJ11, ABCC8

NET-GE enrichment

Term New enriched termICP valueGenes
Inwardly rectifying K+ channels (R-HSA-1296065) -8.030.013KCNJ11, ABCC8
ABC-family proteins mediated transport (R-HSA-382556) -7.590.024KCNJ11, ABCC8
Metabolism (R-HSA-1430728) -2.340.016SLC16A1, GCK, ABCC8, KCNJ11, GLUD1, HADH
ATP sensitive Potassium channels (R-HSA-1296025) -10.980.0KCNJ11, ABCC8
Transmembrane transport of small molecules (R-HSA-382551) -3.790.036SLC16A1, KCNJ11, ABCC8, GCK
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
organic cyclic compound binding (GO:0097159) 1.057SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
binding (GO:0005488) 0.187SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
protein binding (GO:0005515) 0.466SLC16A1, ABCC8, INSR, GCK, GLUD1, KCNJ11
small molecule binding (GO:0036094) 1.896ABCC8, INSR, GCK, KCNJ11, GLUD1, HADH
heterocyclic compound binding (GO:1901363) 1.066ABCC8, INSR, GCK, KCNJ11, GLUD1, HADH
nucleoside phosphate binding (GO:1901265) 1.966ABCC8, INSR, GCK, KCNJ11, GLUD1, HADH
nucleotide binding (GO:0000166) 1.966ABCC8, INSR, GCK, KCNJ11, GLUD1, HADH
adenyl nucleotide binding (GO:0030554) 2.45GLUD1, KCNJ11, INSR, GCK, ABCC8
carbohydrate derivative binding (GO:0097367) 2.035GLUD1, KCNJ11, INSR, ABCC8, GCK
purine ribonucleoside triphosphate binding (GO:0035639) 2.225GLUD1, KCNJ11, INSR, GCK, ABCC8
catalytic activity (GO:0003824) 1.055GLUD1, HADH, ABCC8, INSR, GCK
adenyl ribonucleotide binding (GO:0032559) 2.415GLUD1, KCNJ11, INSR, ABCC8, GCK
ribonucleotide binding (GO:0032553) 2.195GLUD1, KCNJ11, INSR, ABCC8, GCK
purine nucleoside binding (GO:0001883) 2.225GLUD1, KCNJ11, INSR, ABCC8, GCK
ribonucleoside binding (GO:0032549) 2.225GLUD1, KCNJ11, INSR, GCK, ABCC8
purine ribonucleotide binding (GO:0032555) 2.25GLUD1, KCNJ11, INSR, ABCC8, GCK
purine nucleotide binding (GO:0017076) 2.195GLUD1, KCNJ11, INSR, GCK, ABCC8
purine ribonucleoside binding (GO:0032550) 2.225GLUD1, KCNJ11, INSR, ABCC8, GCK
ATP binding (GO:0005524) 2.435GLUD1, KCNJ11, INSR, GCK, ABCC8
nucleoside binding (GO:0001882) 2.215GLUD1, KCNJ11, ABCC8, INSR, GCK
ion binding (GO:0043167) 1.364GLUD1, KCNJ11, GCK, INSR
substrate-specific transmembrane transporter activity (GO:0022891) 2.93SLC16A1, KCNJ11, ABCC8
coenzyme binding (GO:0050662) 4.533HADH, GLUD1, INSR
substrate-specific transporter activity (GO:0022892) 2.723SLC16A1, KCNJ11, ABCC8
transporter activity (GO:0005215) 2.573SLC16A1, KCNJ11, ABCC8
ion transmembrane transporter activity (GO:0015075) 3.043SLC16A1, KCNJ11, ABCC8
molecular transducer activity (GO:0060089) 2.323KCNJ11, ABCC8, INSR
transmembrane transporter activity (GO:0022857) 2.823SLC16A1, KCNJ11, ABCC8
cofactor binding (GO:0048037) 4.163HADH, GLUD1, INSR
receptor activity (GO:0004872) 2.323KCNJ11, INSR, ABCC8
transmembrane receptor activity (GO:0099600) 2.533KCNJ11, INSR, ABCC8
potassium channel activity (GO:0005267) 4.942KCNJ11, ABCC8
cation channel activity (GO:0005261) 4.042KCNJ11, ABCC8
NAD binding (GO:0051287) 5.772HADH, GLUD1
enzyme binding (GO:0019899) 2.272GCK, INSR
transmembrane signaling receptor activity (GO:0004888) 2.572ABCC8, INSR
signal transducer activity (GO:0004871) 2.282ABCC8, INSR
signaling receptor activity (GO:0038023) 2.492ABCC8, INSR
ion channel binding (GO:0044325) 5.022KCNJ11, ABCC8
oxidoreductase activity (GO:0016491) 3.122HADH, GLUD1
anion binding (GO:0043168) 4.172GLUD1, INSR
cation binding (GO:0043169) 1.42KCNJ11, GCK
voltage-gated channel activity (GO:0022832) 4.492KCNJ11, ABCC8
ATP-activated inward rectifier potassium channel activity (GO:0015272) 8.132KCNJ11, ABCC8
anion transmembrane transporter activity (GO:0008509) 4.432SLC16A1, ABCC8
ligand-gated ion channel activity (GO:0015276) 4.82KCNJ11, ABCC8
guanyl ribonucleotide binding (GO:0032561) 3.732GLUD1, INSR
transferase activity (GO:0016740) 1.952INSR, GCK
voltage-gated cation channel activity (GO:0022843) 4.832KCNJ11, ABCC8
passive transmembrane transporter activity (GO:0022803) 3.62KCNJ11, ABCC8
metal ion transmembrane transporter activity (GO:0046873) 3.712KCNJ11, ABCC8
metal ion binding (GO:0046872) 1.412KCNJ11, GCK
active transmembrane transporter activity (GO:0022804) 3.852SLC16A1, ABCC8
GTP binding (GO:0005525) 3.782GLUD1, INSR
cation transmembrane transporter activity (GO:0008324) 3.322KCNJ11, ABCC8
NAD+ binding (GO:0070403) 7.172HADH, GLUD1
ion channel activity (GO:0005216) 3.712KCNJ11, ABCC8
kinase activity (GO:0016301) 2.932INSR, GCK
protein phosphatase binding (GO:0019903) 4.932INSR, GCK
phosphatase binding (GO:0019902) 4.632GCK, INSR
ADP binding (GO:0043531) 6.242GLUD1, GCK
inorganic cation transmembrane transporter activity (GO:0022890) 3.492KCNJ11, ABCC8
substrate-specific channel activity (GO:0022838) 3.672KCNJ11, ABCC8
gated channel activity (GO:0022836) 3.962KCNJ11, ABCC8
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.082INSR, GCK
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.772GCK, INSR
carboxylic acid binding (GO:0031406) 4.642GLUD1, INSR
guanyl nucleotide binding (GO:0019001) 3.732GLUD1, INSR
monovalent inorganic cation transmembrane transporter activity (GO:0015077) 3.872KCNJ11, ABCC8
channel activity (GO:0015267) 3.62KCNJ11, ABCC8
identical protein binding (GO:0042802) 2.632SLC16A1, GLUD1
voltage-gated potassium channel activity (GO:0005249) 5.242KCNJ11, ABCC8
ligand-gated channel activity (GO:0022834) 4.82KCNJ11, ABCC8
voltage-gated ion channel activity (GO:0005244) 4.492KCNJ11, ABCC8
potassium ion transmembrane transporter activity (GO:0015079) 4.772KCNJ11, ABCC8
inward rectifier potassium channel activity (GO:0005242) 6.652KCNJ11, ABCC8

NET-GE enrichment

Term New enriched termICP valueGenes
anion binding (GO:0043168) -4.170.014ABCC8, INSR, GCK, KCNJ11, GLUD1, HADH
ADP binding (GO:0043531) -6.240.025GLUD1, GCK
adenyl nucleotide binding (GO:0030554) -2.40.021GLUD1, KCNJ11, ABCC8, INSR, GCK
NAD binding (GO:0051287) -5.770.028HADH, GLUD1
nucleotide binding (GO:0000166) -1.960.009ABCC8, INSR, GCK, KCNJ11, GLUD1, HADH
small molecule binding (GO:0036094) -1.890.017ABCC8, INSR, GCK, KCNJ11, GLUD1, HADH
adenyl ribonucleotide binding (GO:0032559) -2.410.02GLUD1, KCNJ11, ABCC8, INSR, GCK
ATP binding (GO:0005524) -2.430.018GLUD1, KCNJ11, INSR, ABCC8, GCK
NAD+ binding (GO:0070403) -7.170.002HADH, GLUD1
inward rectifier potassium channel activity (GO:0005242) -6.650.028KCNJ11, ABCC8
nucleoside phosphate binding (GO:1901265) -1.960.009ABCC8, INSR, GCK, KCNJ11, GLUD1, HADH
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of localization (GO:0032879) 1.947SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
regulation of biological quality (GO:0065008) 1.687SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
regulation of transport (GO:0051049) 2.247SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
cellular process (GO:0009987) 0.267SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
regulation of cellular process (GO:0050794) 0.57SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
single-organism cellular process (GO:0044763) 0.657SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
regulation of signaling (GO:0023051) 1.727SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
biological regulation (GO:0065007) 0.397SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
regulation of cell communication (GO:0010646) 1.737SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
regulation of biological process (GO:0050789) 0.457SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
single-organism process (GO:0044699) 0.487SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
single-organism metabolic process (GO:0044710) 1.636SLC16A1, GCK, INSR, KCNJ11, GLUD1, HADH
primary metabolic process (GO:0044238) 0.696SLC16A1, GCK, INSR, KCNJ11, GLUD1, HADH
regulation of establishment of protein localization (GO:0070201) 3.026SLC16A1, GCK, ABCC8, KCNJ11, GLUD1, HADH
regulation of protein secretion (GO:0050708) 3.776SLC16A1, GCK, ABCC8, KCNJ11, GLUD1, HADH
regulation of secretion (GO:0051046) 3.26SLC16A1, GCK, ABCC8, KCNJ11, GLUD1, HADH
regulation of peptide secretion (GO:0002791) 4.386SLC16A1, GCK, ABCC8, KCNJ11, GLUD1, HADH
response to stimulus (GO:0050896) 1.226SLC16A1, ABCC8, INSR, GCK, KCNJ11, HADH
regulation of insulin secretion (GO:0050796) 4.576SLC16A1, GCK, ABCC8, KCNJ11, GLUD1, HADH
regulation of hormone levels (GO:0010817) 3.566SLC16A1, GCK, ABCC8, KCNJ11, GLUD1, HADH
organic substance metabolic process (GO:0071704) 0.636SLC16A1, GCK, INSR, KCNJ11, GLUD1, HADH
regulation of peptide hormone secretion (GO:0090276) 4.416SLC16A1, GCK, ABCC8, KCNJ11, GLUD1, HADH
regulation of hormone secretion (GO:0046883) 4.186SLC16A1, GCK, ABCC8, KCNJ11, GLUD1, HADH
regulation of secretion by cell (GO:1903530) 3.286SLC16A1, GCK, ABCC8, KCNJ11, GLUD1, HADH
metabolic process (GO:0008152) 0.586SLC16A1, GCK, INSR, KCNJ11, GLUD1, HADH
response to chemical (GO:0042221) 1.986SLC16A1, ABCC8, INSR, GCK, KCNJ11, HADH
regulation of peptide transport (GO:0090087) 4.376SLC16A1, GCK, ABCC8, KCNJ11, GLUD1, HADH
regulation of protein transport (GO:0051223) 3.126SLC16A1, GCK, ABCC8, KCNJ11, GLUD1, HADH
response to organic substance (GO:0010033) 2.26SLC16A1, ABCC8, INSR, GCK, KCNJ11, HADH
regulation of protein localization (GO:0032880) 2.886SLC16A1, GCK, ABCC8, KCNJ11, GLUD1, HADH
response to oxygen-containing compound (GO:1901700) 2.575KCNJ11, INSR, ABCC8, HADH, GCK
response to endogenous stimulus (GO:0009719) 2.795HADH, INSR, ABCC8, KCNJ11, GCK
cellular response to stimulus (GO:0051716) 1.975SLC16A1, KCNJ11, ABCC8, INSR, GCK
negative regulation of transport (GO:0051051) 3.65HADH, INSR, ABCC8, KCNJ11, GCK
positive regulation of transport (GO:0051050) 2.95GLUD1, KCNJ11, ABCC8, INSR, GCK
response to organonitrogen compound (GO:0010243) 3.25HADH, INSR, ABCC8, KCNJ11, GCK
cellular metabolic process (GO:0044237) 0.695GLUD1, SLC16A1, HADH, INSR, GCK
cellular response to organic substance (GO:0071310) 2.785SLC16A1, INSR, KCNJ11, ABCC8, GCK
small molecule metabolic process (GO:0044281) 2.385GLUD1, SLC16A1, KCNJ11, HADH, GCK
cellular response to chemical stimulus (GO:0070887) 2.575SLC16A1, INSR, KCNJ11, ABCC8, GCK
positive regulation of biological process (GO:0048518) 1.25GLUD1, KCNJ11, ABCC8, INSR, GCK
negative regulation of biological process (GO:0048519) 1.335KCNJ11, INSR, ABCC8, HADH, GCK
response to nitrogen compound (GO:1901698) 3.125HADH, INSR, KCNJ11, ABCC8, GCK
negative regulation of cellular process (GO:0048523) 1.415HADH, INSR, KCNJ11, ABCC8, GCK
organic acid metabolic process (GO:0006082) 3.014GLUD1, SLC16A1, HADH, GCK
response to external stimulus (GO:0009605) 2.554SLC16A1, ABCC8, INSR, GCK
glucose homeostasis (GO:0042593) 4.64SLC16A1, INSR, KCNJ11, GCK
negative regulation of secretion (GO:0051048) 4.444HADH, KCNJ11, ABCC8, GCK
response to hormone (GO:0009725) 3.334HADH, ABCC8, INSR, GCK
ion transport (GO:0006811) 2.664SLC16A1, KCNJ11, ABCC8, GCK
transport (GO:0006810) 1.514SLC16A1, KCNJ11, ABCC8, GCK
carbohydrate homeostasis (GO:0033500) 4.64SLC16A1, KCNJ11, GCK, INSR
carboxylic acid metabolic process (GO:0019752) 3.124GLUD1, SLC16A1, HADH, GCK
localization (GO:0051179) 1.44SLC16A1, KCNJ11, ABCC8, GCK
homeostatic process (GO:0042592) 2.614SLC16A1, INSR, KCNJ11, GCK
negative regulation of signaling (GO:0023057) 2.654HADH, KCNJ11, ABCC8, GCK
chemical homeostasis (GO:0048878) 2.974SLC16A1, KCNJ11, INSR, GCK
negative regulation of secretion by cell (GO:1903531) 4.554HADH, KCNJ11, ABCC8, GCK
negative regulation of cell communication (GO:0010648) 2.664HADH, KCNJ11, ABCC8, GCK
response to insulin (GO:0032868) 4.724HADH, INSR, ABCC8, GCK
negative regulation of hormone secretion (GO:0046888) 5.414HADH, KCNJ11, ABCC8, GCK
response to peptide (GO:1901652) 3.944HADH, INSR, ABCC8, GCK
oxoacid metabolic process (GO:0043436) 3.124GLUD1, SLC16A1, HADH, GCK
establishment of localization (GO:0051234) 1.484SLC16A1, KCNJ11, ABCC8, GCK
response to peptide hormone (GO:0043434) 4.064HADH, INSR, ABCC8, GCK
cellular response to endogenous stimulus (GO:0071495) 3.333KCNJ11, INSR, GCK
response to extracellular stimulus (GO:0009991) 3.713SLC16A1, GCK, INSR
positive regulation of signaling (GO:0023056) 2.413GLUD1, GCK, INSR
response to organic cyclic compound (GO:0014070) 3.073SLC16A1, KCNJ11, INSR
signal transduction (GO:0007165) 1.283INSR, ABCC8, GCK
small molecule catabolic process (GO:0044282) 3.993HADH, GLUD1, GCK
positive regulation of cell communication (GO:0010647) 2.413GLUD1, GCK, INSR
negative regulation of protein transport (GO:0051224) 4.443HADH, KCNJ11, ABCC8
negative regulation of establishment of protein localization (GO:1904950) 4.393HADH, KCNJ11, ABCC8
regulation of ion transport (GO:0043269) 3.43KCNJ11, ABCC8, GCK
single-organism catabolic process (GO:0044712) 3.213HADH, GLUD1, GCK
organic substance catabolic process (GO:1901575) 2.453HADH, GLUD1, GCK
negative regulation of protein secretion (GO:0050709) 5.063HADH, KCNJ11, ABCC8
response to lipid (GO:0033993) 3.113KCNJ11, ABCC8, INSR
cellular response to organonitrogen compound (GO:0071417) 3.873KCNJ11, INSR, GCK
single-organism localization (GO:1902578) 2.093KCNJ11, ABCC8, GCK
negative regulation of peptide hormone secretion (GO:0090278) 5.883HADH, KCNJ11, ABCC8
cation transport (GO:0006812) 3.113KCNJ11, GCK, ABCC8
monocarboxylic acid metabolic process (GO:0032787) 3.573SLC16A1, HADH, GCK
ion transmembrane transport (GO:0034220) 3.083SLC16A1, KCNJ11, ABCC8
single-organism transport (GO:0044765) 2.183KCNJ11, ABCC8, GCK
metal ion transport (GO:0030001) 3.363KCNJ11, ABCC8, GCK
catabolic process (GO:0009056) 2.383HADH, GLUD1, GCK
transmembrane transport (GO:0055085) 2.723SLC16A1, KCNJ11, ABCC8
oxidation-reduction process (GO:0055114) 2.913HADH, GLUD1, GCK
cellular response to oxygen-containing compound (GO:1901701) 3.223KCNJ11, INSR, GCK
carbohydrate metabolic process (GO:0005975) 3.263KCNJ11, INSR, GCK
negative regulation of peptide secretion (GO:0002792) 5.843HADH, KCNJ11, ABCC8
cellular response to nitrogen compound (GO:1901699) 3.793KCNJ11, INSR, GCK
response to drug (GO:0042493) 3.713HADH, KCNJ11, ABCC8
response to nutrient levels (GO:0031667) 3.773SLC16A1, GCK, INSR
positive regulation of cellular process (GO:0048522) 1.33GLUD1, INSR, GCK
negative regulation of insulin secretion (GO:0046676) 5.993HADH, KCNJ11, ABCC8
positive regulation of insulin secretion (GO:0032024) 5.572GLUD1, GCK
regulation of phosphate metabolic process (GO:0019220) 2.352GCK, INSR
regulation of primary metabolic process (GO:0080090) 1.082GCK, INSR
regulation of metabolic process (GO:0019222) 1.022GCK, INSR
positive regulation of secretion (GO:0051047) 3.852GLUD1, GCK
regulation of ATP metabolic process (GO:1903578) 5.822GCK, INSR
anion transport (GO:0006820) 3.712SLC16A1, ABCC8
positive regulation of nucleotide metabolic process (GO:0045981) 4.852INSR, GCK
cellular component organization or biogenesis (GO:0071840) 1.222SLC16A1, INSR
single-organism biosynthetic process (GO:0044711) 2.82GLUD1, GCK
positive regulation of macromolecule metabolic process (GO:0010604) 1.812GCK, INSR
positive regulation of molecular function (GO:0044093) 2.232KCNJ11, INSR
inorganic cation transmembrane transport (GO:0098662) 3.552KCNJ11, ABCC8
cellular homeostasis (GO:0019725) 3.232KCNJ11, GCK
regulation of phosphorylation (GO:0042325) 2.52GCK, INSR
regulation of macromolecule metabolic process (GO:0060255) 1.082GCK, INSR
response to activity (GO:0014823) 5.472HADH, INSR
positive regulation of phosphorylation (GO:0042327) 2.92GCK, INSR
positive regulation of peptide hormone secretion (GO:0090277) 5.262GLUD1, GCK
response to metal ion (GO:0010038) 3.912ABCC8, INSR
regulation of glycogen metabolic process (GO:0070873) 6.172GCK, INSR
positive regulation of glycogen metabolic process (GO:0070875) 6.92INSR, GCK
regulation of coenzyme metabolic process (GO:0051196) 5.82GCK, INSR
positive regulation of coenzyme metabolic process (GO:0051197) 7.022GCK, INSR
positive regulation of cofactor metabolic process (GO:0051194) 7.022GCK, INSR
organonitrogen compound metabolic process (GO:1901564) 2.322GLUD1, GCK
regulation of cofactor metabolic process (GO:0051193) 5.82INSR, GCK
response to monosaccharide (GO:0034284) 4.772KCNJ11, GCK
organic acid catabolic process (GO:0016054) 4.442HADH, GLUD1
positive regulation of glycolytic process (GO:0045821) 7.092INSR, GCK
monosaccharide metabolic process (GO:0005996) 4.572KCNJ11, GCK
positive regulation of catabolic process (GO:0009896) 3.942GCK, INSR
regulation of catabolic process (GO:0009894) 3.522INSR, GCK
negative regulation of metabolic process (GO:0009892) 1.932INSR, GCK
positive regulation of metabolic process (GO:0009893) 1.742INSR, GCK
positive regulation of biosynthetic process (GO:0009891) 2.292INSR, GCK
regulation of glucose metabolic process (GO:0010906) 5.082GCK, INSR
positive regulation of glucose metabolic process (GO:0010907) 6.152INSR, GCK
nitrogen compound metabolic process (GO:0006807) 1.132GLUD1, GCK
positive regulation of protein transport (GO:0051222) 3.612GLUD1, GCK
lipid metabolic process (GO:0006629) 2.682SLC16A1, HADH
organic substance biosynthetic process (GO:1901576) 1.342GLUD1, GCK
cellular macromolecule metabolic process (GO:0044260) 0.932GCK, INSR
cellular component organization (GO:0016043) 1.242SLC16A1, INSR
regulation of glucan biosynthetic process (GO:0010962) 6.332GCK, INSR
regulation of glycolytic process (GO:0006110) 6.262GCK, INSR
inorganic ion transmembrane transport (GO:0098660) 3.382KCNJ11, ABCC8
positive regulation of carbohydrate metabolic process (GO:0045913) 5.42GCK, INSR
positive regulation of glycogen biosynthetic process (GO:0045725) 7.022GCK, INSR
regulation of molecular function (GO:0065009) 1.782KCNJ11, INSR
response to cytokine (GO:0034097) 3.842KCNJ11, INSR
potassium ion transport (GO:0006813) 4.682KCNJ11, ABCC8
regulation of biosynthetic process (GO:0009889) 1.372GCK, INSR
hexose metabolic process (GO:0019318) 4.642KCNJ11, GCK
response to stress (GO:0006950) 1.82KCNJ11, GCK
cellular glucose homeostasis (GO:0001678) 5.482KCNJ11, GCK
single-organism carbohydrate metabolic process (GO:0044723) 3.422KCNJ11, GCK
regulation of carbohydrate biosynthetic process (GO:0043255) 5.252INSR, GCK
single-organism developmental process (GO:0044767) 1.492GLUD1, INSR
positive regulation of protein secretion (GO:0050714) 4.392GLUD1, GCK
carboxylic acid catabolic process (GO:0046395) 4.582HADH, GLUD1
response to testosterone (GO:0033574) 6.092KCNJ11, INSR
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392GCK, INSR
regulation of macromolecule biosynthetic process (GO:0010556) 1.432INSR, GCK
regulation of carbohydrate metabolic process (GO:0006109) 4.572INSR, GCK
regulation of multicellular organismal process (GO:0051239) 1.872KCNJ11, INSR
phosphorylation (GO:0016310) 2.632GCK, INSR
cellular catabolic process (GO:0044248) 2.622HADH, GLUD1
cellular biosynthetic process (GO:0044249) 1.372GLUD1, GCK
regulation of phosphorus metabolic process (GO:0051174) 2.352GCK, INSR
positive regulation of secretion by cell (GO:1903532) 3.932GLUD1, GCK
regulation of polysaccharide biosynthetic process (GO:0032885) 6.092INSR, GCK
positive regulation of establishment of protein localization (GO:1904951) 3.492GLUD1, GCK
regulation of polysaccharide metabolic process (GO:0032881) 5.972GCK, INSR
cellular response to peptide hormone stimulus (GO:0071375) 4.632INSR, GCK
cellular potassium ion transport (GO:0071804) 4.792KCNJ11, ABCC8
potassium ion transmembrane transport (GO:0071805) 4.792KCNJ11, ABCC8
positive regulation of phosphorus metabolic process (GO:0010562) 2.782GCK, INSR
regulation of transporter activity (GO:0032409) 4.452KCNJ11, INSR
positive regulation of nucleoside metabolic process (GO:0045979) 6.552INSR, GCK
monovalent inorganic cation transport (GO:0015672) 3.742KCNJ11, ABCC8
developmental process (GO:0032502) 1.362GLUD1, INSR
positive regulation of cellular catabolic process (GO:0031331) 4.152GCK, INSR
positive regulation of ion transport (GO:0043270) 4.362KCNJ11, ABCC8
cellular response to hormone stimulus (GO:0032870) 3.992GCK, INSR
regulation of cellular carbohydrate metabolic process (GO:0010675) 4.812GCK, INSR
positive regulation of cellular carbohydrate metabolic process (GO:0010676) 5.722GCK, INSR
positive regulation of hormone secretion (GO:0046887) 4.982GLUD1, GCK
cellular chemical homeostasis (GO:0055082) 3.42KCNJ11, GCK
positive regulation of purine nucleotide metabolic process (GO:1900544) 4.852GCK, INSR
regulation of carbohydrate catabolic process (GO:0043470) 5.972GCK, INSR
cellular response to organic cyclic compound (GO:0071407) 3.932SLC16A1, KCNJ11
macromolecule metabolic process (GO:0043170) 0.832INSR, GCK
glucose metabolic process (GO:0006006) 4.942KCNJ11, GCK
response to inorganic substance (GO:0010035) 3.562ABCC8, INSR
positive regulation of peptide secretion (GO:0002793) 5.222GLUD1, GCK
regulation of cellular catabolic process (GO:0031329) 3.832GCK, INSR
positive regulation of cellular biosynthetic process (GO:0031328) 2.32GCK, INSR
regulation of cellular biosynthetic process (GO:0031326) 1.382GCK, INSR
response to transition metal nanoparticle (GO:1990267) 4.72ABCC8, INSR
negative regulation of cellular metabolic process (GO:0031324) 2.012GCK, INSR
regulation of cellular metabolic process (GO:0031323) 1.072INSR, GCK
regulation of potassium ion transport (GO:0043266) 5.312ABCC8, GCK
regulation of glucose transport (GO:0010827) 5.122INSR, GCK
cellular response to insulin stimulus (GO:0032869) 5.292GCK, INSR
pyruvate metabolic process (GO:0006090) 5.512SLC16A1, GCK
response to estradiol (GO:0032355) 4.732KCNJ11, INSR
regulation of generation of precursor metabolites and energy (GO:0043467) 5.242INSR, GCK
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462INSR, GCK
response to ketone (GO:1901654) 4.532KCNJ11, INSR
positive regulation of ATP metabolic process (GO:1903580) 6.552INSR, GCK
organic substance transport (GO:0071702) 2.152SLC16A1, GCK
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352INSR, GCK
positive regulation of phosphate metabolic process (GO:0045937) 2.782INSR, GCK
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432INSR, GCK
response to tumor necrosis factor (GO:0034612) 4.932KCNJ11, INSR
regulation of metal ion transport (GO:0010959) 3.942ABCC8, GCK
biosynthetic process (GO:0009058) 1.322GLUD1, GCK
regulation of nitrogen compound metabolic process (GO:0051171) 1.362INSR, GCK
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292GCK, INSR
regulation of nucleoside metabolic process (GO:0009118) 5.822GCK, INSR
response to hexose (GO:0009746) 4.822KCNJ11, GCK
regulation of purine nucleotide metabolic process (GO:1900542) 4.412INSR, GCK
response to carbohydrate (GO:0009743) 4.622KCNJ11, GCK
regulation of glycogen biosynthetic process (GO:0005979) 6.332INSR, GCK
anatomical structure development (GO:0048856) 1.582GLUD1, INSR
positive regulation of cellular metabolic process (GO:0031325) 1.812GCK, INSR
response to glucose (GO:0009749) 4.862KCNJ11, GCK
phosphate-containing compound metabolic process (GO:0006796) 2.162GCK, INSR
cellular response to peptide (GO:1901653) 4.522GCK, INSR
phosphorus metabolic process (GO:0006793) 2.152INSR, GCK
anion transmembrane transport (GO:0098656) 4.512SLC16A1, ABCC8
regulation of nucleotide metabolic process (GO:0006140) 4.382GCK, INSR
cation transmembrane transport (GO:0098655) 3.432KCNJ11, ABCC8

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of peptide transport (GO:0090087) -4.370.0SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
regulation of cellular localization (GO:0060341) NEW3.030.003SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
negative regulation of secretion (GO:0051048) -4.440.01HADH, KCNJ11, ABCC8, GCK
regulation of transport (GO:0051049) -2.240.0SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
positive regulation of glucose metabolic process (GO:0010907) -6.150.033INSR, GCK
small molecule metabolic process (GO:0044281) -2.380.041SLC16A1, GCK, ABCC8, KCNJ11, GLUD1, HADH
regulation of signaling (GO:0023051) -1.720.0SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
response to insulin (GO:0032868) -4.720.043HADH, GCK, INSR
regulation of polysaccharide biosynthetic process (GO:0032885) -6.090.04INSR, GCK
regulation of cell communication (GO:0010646) -1.730.0SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
generation of precursor metabolites and energy (GO:0006091) NEW4.070.0ABCC8, INSR, GCK, KCNJ11, GLUD1, HADH
regulation of glucan biosynthetic process (GO:0010962) -6.330.027GCK, INSR
single-organism metabolic process (GO:0044710) -1.630.049SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
regulation of localization (GO:0032879) -1.940.0SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
regulation of secretion (GO:0051046) -3.20.0SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
cellular response to organonitrogen compound (GO:0071417) -3.870.036GLUD1, KCNJ11, INSR, GCK, ABCC8
carbohydrate homeostasis (GO:0033500) -4.60.0KCNJ11, INSR, SLC16A1, GCK
energy reserve metabolic process (GO:0006112) NEW5.440.011KCNJ11, ABCC8, GCK
regulation of glycolytic process (GO:0006110) -6.260.022GCK, INSR
positive regulation of glycogen biosynthetic process (GO:0045725) -7.020.026INSR, GCK
negative regulation of transport (GO:0051051) -3.60.001ABCC8, INSR, GCK, KCNJ11, GLUD1, HADH
positive regulation of transport (GO:0051050) -2.90.025GLUD1, KCNJ11, INSR, GCK
regulation of insulin secretion (GO:0050796) -4.570.0SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
regulation of peptide hormone secretion (GO:0090276) -4.410.0SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
regulation of hormone secretion (GO:0046883) -4.180.0SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
response to organonitrogen compound (GO:0010243) -3.20.034ABCC8, INSR, GCK, KCNJ11, GLUD1, HADH
negative regulation of hormone secretion (GO:0046888) -5.410.0HADH, KCNJ11, ABCC8, GCK
regulation of glycogen metabolic process (GO:0070873) -6.170.04INSR, GCK
negative regulation of peptide hormone secretion (GO:0090278) -5.880.006HADH, KCNJ11, ABCC8
positive regulation of glycogen metabolic process (GO:0070875) -6.90.009GCK, INSR
oxidation-reduction process (GO:0055114) -2.910.007GLUD1, HADH, KCNJ11, ABCC8, GCK
response to carbohydrate (GO:0009743) -4.620.012KCNJ11, INSR, ABCC8, GCK
regulation of carbohydrate catabolic process (GO:0043470) -5.970.036INSR, GCK
regulation of cellular carbohydrate catabolic process (GO:0043471) NEW7.090.036INSR, GCK
energy derivation by oxidation of organic compounds (GO:0015980) NEW4.930.022KCNJ11, ABCC8, GCK
glucose homeostasis (GO:0042593) -4.60.0SLC16A1, KCNJ11, INSR, GCK
regulation of glycogen biosynthetic process (GO:0005979) -6.330.027INSR, GCK
regulation of peptide secretion (GO:0002791) -4.380.0SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
response to nitrogen compound (GO:1901698) -3.120.024ABCC8, INSR, GCK, KCNJ11, GLUD1, HADH
chemical homeostasis (GO:0048878) -2.970.044SLC16A1, KCNJ11, GCK, INSR
positive regulation of glycolytic process (GO:0045821) -7.090.005GCK, INSR
negative regulation of peptide secretion (GO:0002792) -5.840.042HADH, KCNJ11, ABCC8
negative regulation of insulin secretion (GO:0046676) -5.990.004HADH, KCNJ11, ABCC8
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.287SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
intracellular organelle part (GO:0044446) 0.817SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
cytoplasmic part (GO:0044444) 0.827SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
cell part (GO:0044464) 0.117SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
organelle part (GO:0044422) 0.797SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
intracellular organelle (GO:0043229) 0.516SLC16A1, GCK, INSR, KCNJ11, GLUD1, HADH
membrane-bounded organelle (GO:0043227) 0.476SLC16A1, GCK, INSR, KCNJ11, GLUD1, HADH
intracellular membrane-bounded organelle (GO:0043231) 0.66SLC16A1, GCK, INSR, KCNJ11, GLUD1, HADH
organelle (GO:0043226) 0.46SLC16A1, GCK, INSR, KCNJ11, GLUD1, HADH
membrane (GO:0016020) 0.685SLC16A1, ABCC8, HADH, INSR, KCNJ11
mitochondrion (GO:0005739) 2.425GLUD1, SLC16A1, KCNJ11, HADH, GCK
membrane part (GO:0044425) 0.954SLC16A1, KCNJ11, ABCC8, INSR
integral component of membrane (GO:0016021) 1.144SLC16A1, KCNJ11, ABCC8, INSR
plasma membrane part (GO:0044459) 1.954SLC16A1, INSR, KCNJ11, ABCC8
intrinsic component of membrane (GO:0031224) 1.134SLC16A1, INSR, KCNJ11, ABCC8
plasma membrane (GO:0005886) 1.394SLC16A1, KCNJ11, ABCC8, INSR
protein complex (GO:0043234) 1.513KCNJ11, INSR, ABCC8
cytoplasm (GO:0005737) 1.013HADH, GLUD1, GCK
macromolecular complex (GO:0032991) 1.353KCNJ11, INSR, ABCC8
vesicle (GO:0031982) 1.643SLC16A1, GCK, INSR
cytosol (GO:0005829) 1.683KCNJ11, INSR, GCK
membrane-bounded vesicle (GO:0031988) 1.713SLC16A1, GCK, INSR
plasma membrane protein complex (GO:0098797) 3.553KCNJ11, ABCC8, INSR
membrane protein complex (GO:0098796) 2.843KCNJ11, INSR, ABCC8
nuclear part (GO:0044428) 1.553HADH, KCNJ11, GCK
integral component of plasma membrane (GO:0005887) 2.573SLC16A1, KCNJ11, INSR
intrinsic component of plasma membrane (GO:0031226) 2.533SLC16A1, KCNJ11, INSR
organelle membrane (GO:0031090) 1.973HADH, ABCC8, INSR
plasma membrane region (GO:0098590) 2.972KCNJ11, INSR
membrane-enclosed lumen (GO:0031974) 3.052HADH, GLUD1
potassium channel complex (GO:0034705) 5.322KCNJ11, ABCC8
ion channel complex (GO:0034702) 4.182KCNJ11, ABCC8
cation channel complex (GO:0034703) 4.692KCNJ11, ABCC8
sarcolemma (GO:0042383) 5.22KCNJ11, ABCC8
extracellular exosome (GO:0070062) 1.892SLC16A1, INSR
vacuole (GO:0005773) 2.922KCNJ11, INSR
whole membrane (GO:0098805) 2.852ABCC8, INSR
nucleoplasm (GO:0005654) 1.892HADH, GCK
neuron part (GO:0097458) 2.642KCNJ11, ABCC8
cytoskeletal part (GO:0044430) 2.492SLC16A1, GCK
mitochondrial matrix (GO:0005759) 4.032HADH, GLUD1
transmembrane transporter complex (GO:1902495) 4.062KCNJ11, ABCC8
bounding membrane of organelle (GO:0098588) 2.392ABCC8, INSR
transporter complex (GO:1990351) 4.042KCNJ11, ABCC8
voltage-gated potassium channel complex (GO:0008076) 5.342KCNJ11, ABCC8
extracellular vesicle (GO:1903561) 1.892SLC16A1, INSR
extracellular organelle (GO:0043230) 1.892SLC16A1, INSR
organelle lumen (GO:0043233) 3.052HADH, GLUD1
extracellular region part (GO:0044421) 1.572SLC16A1, INSR
intracellular organelle lumen (GO:0070013) 3.052HADH, GLUD1
mitochondrial part (GO:0044429) 2.922HADH, GLUD1
endosome (GO:0005768) 3.252KCNJ11, INSR
nucleus (GO:0005634) 1.072GCK, INSR

NET-GE enrichment

Term New enriched termICP valueGenes
myelin sheath (GO:0043209) NEW4.760.015KCNJ11, ABCC8
cell body (GO:0044297) NEW3.740.048GLUD1, KCNJ11, ABCC8, INSR
voltage-gated potassium channel complex (GO:0008076) -5.340.026KCNJ11, ABCC8
mitochondrion (GO:0005739) -2.420.001SLC16A1, ABCC8, GCK, INSR, KCNJ11, GLUD1, HADH
myofibril (GO:0030016) NEW6.140.038KCNJ11, ABCC8
potassium channel complex (GO:0034705) -5.320.026KCNJ11, ABCC8
neuronal cell body (GO:0043025) NEW3.90.028GLUD1, KCNJ11, INSR, ABCC8