Disease table of PANCREATIC CANCER OMIM ID: 260350

Gene-disease associations table

GeneAssociated with PANCREATIC CANCER inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
RBBP8ClinVar, OMIMHGNC link18q11.23251255, 260350, PS210600
TP53ClinVar, OMIMHGNC link17p13.112114550, 260500, 605027, PS137800, 614740, 114480, 260350, 607107, 202300, 114500, PS151623, 259500
ACVR1BOMIMHGNC link12q13.131260350
SMAD4ClinVar, OMIMHGNC link18q21.24260350, 174900, 139210, 175050
STK11ClinVar, OMIMHGNC link19p13.34175200, 273300, PS155600, 260350
KRASClinVar, OMIMHGNC link12p12.114601626, 600268, 137215, 109800, PS163950, 211980, 114480, PS115150, 613659, 163200, 607785, 614470, 162900, 260350

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
18q2RBBP8, SMAD4
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
182RBBP8, SMAD4
122KRAS, ACVR1B
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
TP53YES159ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING11TP53
SMAD4YES23SERPINE1, RUNX1T1, EPO, BTRC, BGLAP, POR, CDKN2B, BAMBI, SMAD7, DACH1, TGFB1, CDKN1A, HP, JUN, PDGFRA, AHR, TNC, FSTL3, FBXO32, APOC3, SKIL, MYC, ZFP360
MYCNO102CBFB, PRDX3, CHKA, ATF3, CDK4, PCNA, CEBPA, LDHA, DKK1, MTDH, TFAP4, HLA-G, CDC25A, UBE2C, HLA-B, GATA1, TP53, BAG2, PMAIP1, CDK6, WRN, PGK1, TFAM, IGK, JUNB, ZFP36, HNRNPA1, MYB, SART3, EBNA1BP2, TOP1MT, ST3GAL4, CD33, CCND2, PTBP1, CDCA7, RB1, CCNA2, HLA-C, CYP3A4, FMR1, TERT, NFE2, MME, NDRG1, HDAC2, BRD7, FASLG, CCNB1, TP73, RCC1, SFRP1, HLA-F, CFLAR, BCAT1, CD38, TFRC, CCND1, MTA1, KRAS, HNRNPA2B1, CDC34, ST3GAL3, HLA-A, FUT3, NOL7, FTH1P18, VEGFA, EP300, CDK2, ASS1, SURF1, CDC25C, IER3, ST3GAL1, FOXM1, HSPA4, XPO1, CAD, SHMT1, DDX18, IGF2BP1, BMI1, IPO7, BCL2, CXCR4, SRSF1, TLX1, PRODH, NBN, CDKN1A, IFNA1, TNFRSF10B, ID2, CCNE1, SURF2, HLA-E, CREBBP, MAPK1, IL6, EIF4E, ODC12KRAS, TP53
FOSNO56BATF3, BCL2L1, NPPA, FIGF, ACTA1, FGFBP1, DDIT3, CYP1A2, SMAD4, SLC10A2, MMP9, CCK, PGR, LRIG2, NQO1, FOS, EZR, MMP7, PTGS2, NGF, FAS, FMO4, SMAD7, STAR, CLU, SOX7, PLAU, SRR, NOS2, SPI1, PDHA1, MFI2, MMP1, TP53, OXTR, NPY, GSTP1, NTS, NFKB1, PCK2, CXCL8, CD40LG, CREM, PLAUR, IL1A, ERCC4, MMP3, NTF3, CASP9, CSTA, HSPH1, MYC, CCND1, SPRR3, NEFL, FOXA12TP53, SMAD4
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
RBBP8YES1YBX10
TP53YES50ATM, RELA, ERCC2, ETS2, ELF4, EZH2, HDAC9, FOS, PAX5, MCM4, RUVBL1, ZBTB2, EGR1, KLF4, MCM2, AATF, PAX2, TFDP1, STAT1, IRF1, PAX8, HIPK2, HDAC1, SIRT1, MDM4, VHL, ESR1, ING1, IFI16, STAT3, JUN, TP53, ABL1, NUPR1, NFKB1, E2F1, ETS1, CREBBP, HOXA10, NR3C1, YY1, NF1, ING4, HMGA1, SOX6, BDP1, MYC, PPARG, PML, MYCN1TP53
SMAD4YES4CEBPB, KAT2B, JUNB, FOS0
STK11YES4SP1, NFYB, NFYA, NR1H40
KRASYES1MYC0
BGLAPNO11NR3C1, VDR, ATF4, ATF6, SMAD4, GTF2F1, SMAD3, TP53, EP300, MSX2, RARG2TP53, SMAD4
CDKN1ANO118ABL1, TFAP4, TP53, MYF5, TCF3, HDAC9, PAX5, ZBTB2, LCOR, E2F3, ZBTB5, HSF1, ELL, TSC22D3, NCOA1, TAF1, RELA, MYOD1, STAT1, PTTG1, KLF16, ESR1, JUNB, MYCN, KAT2B, AR, BCL6, KLF10, EZH2, ARID1A, JUND, SP1, CEBPB, ZFHX3, ZNF300, EGR1, KLF4, AATF, HDAC7, HBP1, SMARCA4, ESR2, FOXP3, RARA, NELFCD, ING4, HDAC4, TBX2, IRF1, HDAC2, ETV6, SIRT2, MYOG, KLF6, TP73, SOX6, ATM, ERCC2, SMAD4, ETS2, NUPR1, PTMA, MLLT10, SMAD3, ETS1, CBX8, BRCA1, HIPK2, SIRT1, WT1, ZNF76, HDAC1, SMAD2, MLLT3, TFAP2A, EP300, FHL2, TP63, IRF9, EHMT2, TFAP2C, NFIX, RUNX3, RB1, HNF4A, NFIB, TAF5, SOX9, TBP, EAPP, ZBTB17, TAF4, REL, RELB, PML, SMAD7, NPM1, POU5F1, E2F1, TBX3, FOXG1, MYF6, NFIA, ATF2, PARP1, NFKB1, STAT3, GFI1, NR3C1, CREBBP, MTA1, JUN, KLF2, CDX2, SP3, MYC, PPARG, ING12TP53, SMAD4
MYCNO66E2F4, LEF1, PGR, FOXM1, TBP, FUBP1, TP53, MYBL2, SMAD4, MXI1, MYB, AATF, ZNF382, FOS, ZBTB7A, SP1, E2F5, RBL1, TCF4, TBL1X, EP300, SMAD7, HDAC3, TCF3, SRSF1, SMAD3, CNBP, TLX1, ESR1, SIRT1, WT1, APC, CTNNB1, CEBPE, PRDM1, IFI16, DLX5, HDAC10, ZNF300, JUN, ETS2, RELA, BCL6, NFKB1, BRCA1, E2F1, STAT3, HDAC11, CEBPA, HOXA1, PTTG1, PPARG, YY1, MTA1, HDAC2, NF1, SNIP1, RUNX3, RB1, CTCF, ENO1, BDP1, AHR, STAT4, RFX1, HNF4A2TP53, SMAD4
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
RBBP8TP53No13ATM, PIN1, MDM2, PRKDC, FZR1, BARD1, UIMC1, PLK1, RB1, PCNA, BRCA1, CTBP1, EEF1A1
RBBP8SMAD4No4THOC2, EEF1A1, RBL1, LMO4
RBBP8STK11No1LIMS1
RBBP8KRASNo2EEF1A1, RAF1
TP53ACVR1BNo8HSP90AA1, SMURF1, OTUB1, SMAD7, SMAD2, SMAD3, ELAVL1, TSC22D1
TP53SMAD4No48DNMT3L, PIAS1, HERC5, TDG, SMURF1, CSNK1D, RPL28, IRF7, EWSR1, SNW1, STUB1, SP1, ZMIZ1, PIAS2, SUMO1, KLF5, SMAD7, SKI, PSMD11, COPS5, NCOR1, GLI1, SMAD3, FOXO3, KPNB1, CDKN1A, OTUB1, HDAC1, CRYAB, DAXX, SMAD2, PIAS4, ALYREF, RELA, ZBTB7A, EP300, EEF1A1, CREBBP, NR0B2, YY1, BTRC, NLK, UHRF2, HNF4A, SMAD1, UBE2I, NOTCH4, MDM4
TP53STK11Yes15SMARCC1, WDR48, COPS4, TP63, HSPA1A, USP11, TSG101, TP53, HSP90AA1, TUBA1A, SIRT1, SMARCA4, H2AFX, GSK3B, STUB1
TP53KRASNo9PHB, CCT7, BCL2, PML, MAPK1, ELAVL1, BTRC, EEF1A1, LIMA1
ACVR1BSMAD4No7SMURF1, OTUB1, SMAD7, SMAD2, SMAD3, SMAD6, DOK1
ACVR1BSTK11No1HSP90AA1
ACVR1BKRASNo1ELAVL1
SMAD4STK11No7S100A14, BCAS3, SERPINB5, STK11IP, LYPD3, THRSP, STUB1
SMAD4KRASNo7IL24, BCAS3, RASSF5, SERPINB5, BTRC, EEF1A1, THRSP
STK11KRASNo5BCAS3, THRSP, MOCS2, SERPINB5, APP

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
TP53KRASNo1EXOSC4
SMAD4KRASNo1SNW1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
RBBP8TP53No-17KDM1A, TOPBP1, TREX1, CDK2, CHEK1, CCND1, BARD1, NOTCH1, RBPJ, ATR, RB1, TFDP1, TP53BP1, PCNA, BRCA1, CTBP1, H2AFX
RBBP8SMAD4No-6TFDP2, RBL1, CDK2, CCND1, CTBP1, TFDP1
RBBP8STK11No-1CCND1
RBBP8KRASNo-3NOTCH1, CCND1, ANGPT1
TP53ACVR1BNo-4SMAD3, SMAD7, SMAD2, SMAD4
TP53SMAD4Yesactivation, binding83SP7, KAT2B, WWOX, PIAS1, PTEN, RUNX2, HDAC2, SMAD7, SNAI1, CDC25A, XPO1, EPAS1, PIAS4, SIN3A, HNF4A, SERPINE1, CTGF, UBB, CTBP1, HMGA2, STUB1, SP1, RPS27A, CDK4, MAPK1, CTCF, SUMO1, NGFR, RUNX1, CCND1, THBS1, FOS, TFDP1, COPS5, NCOR1, FOXO1, KLF4, TGFB1, SMAD3, FOXO3, HDAC1, BCL6, CDKN1A, ESR1, PIAS2, VDR, SKP2, UBA52, MAPK3, MUC2, MAPK8, CDH1, NOTCH3, MAX, JUN, E2F4, SMAD2, AKT1, PARP1, VEGFA, AR, EP300, UBE2I, ATF3, NR3C1, HIF1A, HSPA8, CDK2, UBE2D1, SIN3B, CREBBP, STK11, BTRC, TWIST1, RUNX3, MMP9, SP3, PRKG1, NANOG, UBC, MYC, YY1, MDM4
TP53STK11Yesactivation, binding26PRKAA2, SMAD4, PRKAA1, HSP90AA1, PRKAB1, CCND1, SIK1, FOXO1, FOXO3, SIRT1, CDKN1A, SMARCA4, TSC2, CCNG1, CTSD, SIRT3, PTEN, VEGFA, GSK3B, LEP, FBXW8, STAT3, TP63, IL6, ESR1, MYC
TP53KRASYesactivation, binding40BCL2L1, ABL1, MAPK1, PTPN11, ETS2, BTRC, NPM1, EGFR, HBEGF, LGALS3, PRMT1, MAPK11, CTGF, CCND1, PTK2, MDM4, EPHA2, ERBB2, RAF1, MAPK14, MAPK7, NCL, HRAS, PRMT5, NOTCH1, MAPK13, JUN, HSP90AA1, AKT1, VEGFA, MAPK12, ETS1, MGMT, BCL2, MAPK3, MTOR, ERBB4, PIK3CA, UBC, TSG101
ACVR1BSMAD4Yesactivation, binding11SMURF1, TGFB2, BMP4, SMAD7, SMAD1, SMAD6, SMAD5, SMAD3, SMAD2, BMP2, SMAD9
ACVR1BSTK11No-1SMAD4
ACVR1BKRASNo-1BMP4
SMAD4STK11Yesactivation, binding11MYC, CDKN1A, FOXO1, ESR1, CCND1, STK11IP, TP53, FOXO4, PTEN, FOXO3, VEGFA
SMAD4KRASNo-14PPARD, CTGF, BMP4, MAPK1, CCND1, MAPK3, JUN, TP53, BTRC, AKT1, UBC, VEGFA, MEN1, MDM4
STK11KRASNo-5HSP90AA1, IRS1, CCND1, VEGFA, TP53

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
RBBP8TP53No-1BARD1
TP53SMAD4No-2SP1, FOXO3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Signaling pathways regulating pluripotency of stem cellshsa045505.63ACVR1B, KRAS, SMAD4
Pancreatic cancerhsa052126.563KRAS, TP53, SMAD4
Colorectal cancerhsa052106.523KRAS, TP53, SMAD4
Pathways in cancerhsa052003.983KRAS, TP53, SMAD4
FoxO signaling pathwayhsa040685.633STK11, KRAS, SMAD4
Chronic myeloid leukemiahsa052206.483KRAS, TP53, SMAD4
HTLV-I infectionhsa051664.593KRAS, TP53, SMAD4
Hepatitis Bhsa051615.523KRAS, TP53, SMAD4
PI3K-Akt signaling pathwayhsa041514.213STK11, KRAS, TP53
TGF-beta signaling pathwayhsa043506.412ACVR1B, SMAD4
Melanomahsa052186.562KRAS, TP53
Bladder cancerhsa052197.382KRAS, TP53
Proteoglycans in cancerhsa052055.022KRAS, TP53
Endometrial cancerhsa052136.812KRAS, TP53
Cell cyclehsa041105.682TP53, SMAD4
MicroRNAs in cancerhsa052065.382KRAS, TP53
Thyroid cancerhsa052167.482KRAS, TP53
Gliomahsa052146.662KRAS, TP53
Prostate cancerhsa052156.112KRAS, TP53
Neurotrophin signaling pathwayhsa047225.782KRAS, TP53
Central carbon metabolism in cancerhsa052306.72KRAS, TP53
Viral carcinogenesishsa052035.082KRAS, TP53
MAPK signaling pathwayhsa040104.632KRAS, TP53
Non-small cell lung cancerhsa052236.882KRAS, TP53
Wnt signaling pathwayhsa043105.492TP53, SMAD4
Thyroid hormone signaling pathwayhsa049195.822KRAS, TP53
Hepatitis Chsa051605.682KRAS, TP53

NET-GE enrichment

Term New enriched termICP valueGenes
TGF-beta signaling pathway (hsa04350) -6.410.021ACVR1B, TP53, SMAD4
Signaling pathways regulating pluripotency of stem cells (hsa04550) -5.60.008ACVR1B, TP53, KRAS, SMAD4
Bladder cancer (hsa05219) -7.380.033KRAS, TP53
Pancreatic cancer (hsa05212) -6.560.008KRAS, TP53, SMAD4
Endometrial cancer (hsa05213) -6.810.004KRAS, TP53, SMAD4
Colorectal cancer (hsa05210) -6.520.008KRAS, TP53, SMAD4
MicroRNAs in cancer (hsa05206) -5.380.005KRAS, STK11, TP53, SMAD4
Thyroid cancer (hsa05216) -7.480.001KRAS, TP53, SMAD4
Prostate cancer (hsa05215) -6.110.02KRAS, TP53, SMAD4
FoxO signaling pathway (hsa04068) -5.630.007KRAS, STK11, TP53, SMAD4
Chronic myeloid leukemia (hsa05220) -6.480.001KRAS, TP53, SMAD4
Hepatitis B (hsa05161) -5.520.009KRAS, TP53, SMAD4
Adipocytokine signaling pathway (hsa04920) NEW6.60.013STK11, TP53, SMAD4
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signal TransductionR-HSA-1625821.785ACVR1B, KRAS, STK11, TP53, SMAD4
Developmental BiologyR-HSA-12667383.483ACVR1B, KRAS, SMAD4
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.852STK11, KRAS
Signaling by NODALR-HSA-11811508.732ACVR1B, SMAD4
Signaling by ActivinR-HSA-15025409.282ACVR1B, SMAD4
Diseases of signal transductionR-HSA-56632024.892KRAS, SMAD4
Generic Transcription PathwayR-HSA-2124363.862TP53, SMAD4
Gene ExpressionR-HSA-741602.722TP53, SMAD4
IRS-mediated signallingR-HSA-1123994.872STK11, KRAS
IRS-related events triggered by IGF1RR-HSA-24289284.852STK11, KRAS
IGF1R signaling cascadeR-HSA-24289244.852STK11, KRAS
Cell CycleR-HSA-16401703.892RBBP8, TP53
Signaling by Insulin receptorR-HSA-747524.732STK11, KRAS
HemostasisR-HSA-1095823.982KRAS, TP53
DiseaseR-HSA-16436853.332KRAS, SMAD4
Insulin receptor signalling cascadeR-HSA-747514.852STK11, KRAS

NET-GE enrichment

Term New enriched termICP valueGenes
Signaling by NODAL (R-HSA-1181150) -8.730.012ACVR1B, SMAD4
Oxidative Stress Induced Senescence (R-HSA-2559580) NEW6.510.026KRAS, TP53, SMAD4
Signaling by Activin (R-HSA-1502540) -9.280.005ACVR1B, SMAD4
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
organic cyclic compound binding (GO:0097159) 1.056TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
heterocyclic compound binding (GO:1901363) 1.066TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
protein binding (GO:0005515) 0.466TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
binding (GO:0005488) 0.186TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
cation binding (GO:0043169) 1.45ACVR1B, TP53, STK11, KRAS, SMAD4
metal ion binding (GO:0046872) 1.415ACVR1B, KRAS, STK11, TP53, SMAD4
ion binding (GO:0043167) 1.365ACVR1B, KRAS, STK11, TP53, SMAD4
carbohydrate derivative binding (GO:0097367) 2.034ACVR1B, STK11, KRAS, TP53
purine ribonucleoside triphosphate binding (GO:0035639) 2.224ACVR1B, STK11, KRAS, TP53
nucleotide binding (GO:0000166) 1.964ACVR1B, STK11, TP53, KRAS
small molecule binding (GO:0036094) 1.894ACVR1B, STK11, KRAS, TP53
catalytic activity (GO:0003824) 1.054RBBP8, ACVR1B, STK11, KRAS
macromolecular complex binding (GO:0044877) 2.614ACVR1B, KRAS, TP53, SMAD4
ribonucleotide binding (GO:0032553) 2.194ACVR1B, STK11, KRAS, TP53
purine nucleoside binding (GO:0001883) 2.224ACVR1B, STK11, TP53, KRAS
ribonucleoside binding (GO:0032549) 2.224ACVR1B, STK11, KRAS, TP53
purine ribonucleotide binding (GO:0032555) 2.24ACVR1B, STK11, KRAS, TP53
purine nucleotide binding (GO:0017076) 2.194ACVR1B, STK11, KRAS, TP53
purine ribonucleoside binding (GO:0032550) 2.224ACVR1B, STK11, KRAS, TP53
nucleoside phosphate binding (GO:1901265) 1.964ACVR1B, STK11, TP53, KRAS
nucleoside binding (GO:0001882) 2.214ACVR1B, STK11, KRAS, TP53
RNA polymerase II transcription factor binding (GO:0001085) 5.083RBBP8, TP53, SMAD4
adenyl nucleotide binding (GO:0030554) 2.43ACVR1B, STK11, TP53
transcription factor binding (GO:0008134) 3.463RBBP8, TP53, SMAD4
adenyl ribonucleotide binding (GO:0032559) 2.413ACVR1B, STK11, TP53
nucleic acid binding (GO:0003676) 1.443RBBP8, TP53, SMAD4
DNA binding (GO:0003677) 1.923RBBP8, TP53, SMAD4
protein complex binding (GO:0032403) 3.093ACVR1B, KRAS, SMAD4
ATP binding (GO:0005524) 2.433ACVR1B, STK11, TP53
ubiquitin-like protein ligase binding (GO:0044389) 4.152ACVR1B, TP53
enzyme binding (GO:0019899) 2.272ACVR1B, TP53
transcription factor activity, RNA polymerase II transcription factor binding (GO:0001076) 4.842RBBP8, SMAD4
nucleic acid binding transcription factor activity (GO:0001071) 2.652TP53, SMAD4
signal transducer activity (GO:0004871) 2.282ACVR1B, SMAD4
sequence-specific DNA binding (GO:0043565) 2.792TP53, SMAD4
sequence-specific double-stranded DNA binding (GO:1990837) 3.22TP53, SMAD4
receptor signaling protein activity (GO:0005057) 4.762ACVR1B, SMAD4
chromatin binding (GO:0003682) 3.642TP53, SMAD4
protein serine/threonine kinase activity (GO:0004674) 3.642ACVR1B, STK11
transferase activity (GO:0016740) 1.952ACVR1B, STK11
transcription factor activity, transcription factor binding (GO:0000989) 3.362RBBP8, SMAD4
transcription factor activity, protein binding (GO:0000988) 3.352RBBP8, SMAD4
double-stranded DNA binding (GO:0003690) 3.092TP53, SMAD4
identical protein binding (GO:0042802) 2.632TP53, SMAD4
hydrolase activity (GO:0016787) 1.92RBBP8, KRAS
kinase activity (GO:0016301) 2.932ACVR1B, STK11
regulatory region nucleic acid binding (GO:0001067) 3.032TP53, SMAD4
SMAD binding (GO:0046332) 5.452ACVR1B, SMAD4
protein domain specific binding (GO:0019904) 3.322STK11, KRAS
LRR domain binding (GO:0030275) 6.912STK11, KRAS
protein kinase activity (GO:0004672) 3.272ACVR1B, STK11
transcription regulatory region DNA binding (GO:0044212) 3.032TP53, SMAD4
ubiquitin protein ligase binding (GO:0031625) 4.172ACVR1B, TP53
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.082ACVR1B, STK11
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.772ACVR1B, STK11
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228) 3.982TP53, SMAD4
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.652TP53, SMAD4
transcription regulatory region sequence-specific DNA binding (GO:0000976) 3.242TP53, SMAD4
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.292TP53, SMAD4
regulatory region DNA binding (GO:0000975) 3.032TP53, SMAD4
protein dimerization activity (GO:0046983) 2.722TP53, SMAD4
protein heterodimerization activity (GO:0046982) 3.642TP53, SMAD4
p53 binding (GO:0002039) 5.532STK11, TP53
damaged DNA binding (GO:0003684) 5.582RBBP8, TP53

NET-GE enrichment

Term New enriched termICP valueGenes
RNA polymerase II transcription factor binding (GO:0001085) -5.080.017RBBP8, TP53, SMAD4
RNA polymerase II transcription cofactor activity (GO:0001104) NEW5.220.01RBBP8, TP53, SMAD4
transforming growth factor beta receptor, cytoplasmic mediator activity (GO:0005072) NEW7.440.004ACVR1B, SMAD4
LRR domain binding (GO:0030275) -6.910.001STK11, KRAS
phosphotransferase activity, alcohol group as acceptor (GO:0016773) -3.080.044ACVR1B, TP53, STK11, KRAS, SMAD4
transcription corepressor activity (GO:0003714) NEW4.330.01KRAS, RBBP8, TP53, SMAD4
transcription factor binding (GO:0008134) -3.460.04RBBP8, TP53, SMAD4
RNA polymerase II transcription factor binding transcription factor activity (GO:0001076) -4.840.041RBBP8, TP53, SMAD4
histone acetyltransferase binding (GO:0035035) NEW6.410.022TP53, SMAD4
damaged DNA binding (GO:0003684) -5.580.019RBBP8, TP53
SMAD binding (GO:0046332) -5.450.027ACVR1B, TP53, SMAD4
cyclin-dependent protein serine/threonine kinase regulator activity (GO:0016538) NEW6.410.029TP53, SMAD4
RNA polymerase II repressing transcription factor binding (GO:0001103) NEW6.440.041RBBP8, SMAD4
protein kinase activity (GO:0004672) -3.270.021ACVR1B, TP53, STK11, KRAS, SMAD4
p53 binding (GO:0002039) -5.530.018STK11, TP53
phosphatase regulator activity (GO:0019208) NEW5.260.006KRAS, TP53, SMAD4
ATP binding (GO:0005524) -2.430.046TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
repressing transcription factor binding (GO:0070491) NEW5.710.002RBBP8, TP53, SMAD4
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of primary metabolic process (GO:0080090) 1.086TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
regulation of metabolic process (GO:0019222) 1.026TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
regulation of response to stimulus (GO:0048583) 1.546TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
regulation of signaling (GO:0023051) 1.726TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
regulation of cell communication (GO:0010646) 1.736TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
regulation of biological process (GO:0050789) 0.456TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
single-organism process (GO:0044699) 0.486TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
cellular macromolecule metabolic process (GO:0044260) 0.936TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
regulation of signal transduction (GO:0009966) 1.846TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
organic substance metabolic process (GO:0071704) 0.636TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
biological regulation (GO:0065007) 0.396TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
negative regulation of biological process (GO:0048519) 1.336TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
regulation of macromolecule metabolic process (GO:0060255) 1.086TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
regulation of cellular metabolic process (GO:0031323) 1.076TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
cellular process (GO:0009987) 0.266TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
regulation of biosynthetic process (GO:0009889) 1.376TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
regulation of cellular process (GO:0050794) 0.56TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
single-organism cellular process (GO:0044763) 0.656TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
metabolic process (GO:0008152) 0.586TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
primary metabolic process (GO:0044238) 0.696TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
cellular metabolic process (GO:0044237) 0.696TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
macromolecule metabolic process (GO:0043170) 0.836TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
negative regulation of cellular process (GO:0048523) 1.416TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
positive regulation of protein modification process (GO:0031401) 2.75ACVR1B, KRAS, STK11, TP53, SMAD4
negative regulation of metabolic process (GO:0009892) 1.935RBBP8, ACVR1B, STK11, TP53, SMAD4
positive regulation of metabolic process (GO:0009893) 1.745ACVR1B, KRAS, STK11, TP53, SMAD4
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.465ACVR1B, TP53, RBBP8, KRAS, SMAD4
positive regulation of cellular metabolic process (GO:0031325) 1.815ACVR1B, TP53, STK11, KRAS, SMAD4
positive regulation of response to stimulus (GO:0048584) 2.185ACVR1B, KRAS, STK11, TP53, SMAD4
regulation of cellular biosynthetic process (GO:0031326) 1.385ACVR1B, TP53, RBBP8, KRAS, SMAD4
positive regulation of signaling (GO:0023056) 2.415ACVR1B, TP53, STK11, KRAS, SMAD4
signal transduction (GO:0007165) 1.285ACVR1B, TP53, STK11, KRAS, SMAD4
regulation of phosphate metabolic process (GO:0019220) 2.355ACVR1B, TP53, STK11, KRAS, SMAD4
positive regulation of cell communication (GO:0010647) 2.415ACVR1B, TP53, STK11, KRAS, SMAD4
cellular component organization or biogenesis (GO:0071840) 1.225RBBP8, KRAS, STK11, TP53, SMAD4
positive regulation of macromolecule metabolic process (GO:0010604) 1.815ACVR1B, KRAS, STK11, TP53, SMAD4
positive regulation of signal transduction (GO:0009967) 2.55ACVR1B, TP53, STK11, KRAS, SMAD4
positive regulation of phosphorus metabolic process (GO:0010562) 2.785ACVR1B, TP53, STK11, KRAS, SMAD4
regulation of protein metabolic process (GO:0051246) 1.935ACVR1B, KRAS, STK11, TP53, SMAD4
positive regulation of protein metabolic process (GO:0051247) 2.435ACVR1B, TP53, STK11, KRAS, SMAD4
cellular component organization (GO:0016043) 1.245RBBP8, KRAS, STK11, TP53, SMAD4
positive regulation of cellular protein metabolic process (GO:0032270) 2.495ACVR1B, KRAS, STK11, TP53, SMAD4
regulation of protein modification process (GO:0031399) 2.325ACVR1B, KRAS, STK11, TP53, SMAD4
positive regulation of biological process (GO:0048518) 1.25ACVR1B, TP53, STK11, KRAS, SMAD4
regulation of biological quality (GO:0065008) 1.685ACVR1B, TP53, STK11, KRAS, SMAD4
regulation of gene expression (GO:0010468) 1.375ACVR1B, KRAS, RBBP8, TP53, SMAD4
developmental process (GO:0032502) 1.365ACVR1B, TP53, STK11, KRAS, SMAD4
multicellular organismal process (GO:0032501) 1.455ACVR1B, KRAS, RBBP8, TP53, SMAD4
positive regulation of phosphate metabolic process (GO:0045937) 2.785ACVR1B, KRAS, STK11, TP53, SMAD4
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.435ACVR1B, KRAS, RBBP8, TP53, SMAD4
regulation of nucleic acid-templated transcription (GO:1903506) 1.555ACVR1B, TP53, RBBP8, KRAS, SMAD4
single-organism developmental process (GO:0044767) 1.495ACVR1B, KRAS, STK11, TP53, SMAD4
regulation of nitrogen compound metabolic process (GO:0051171) 1.365ACVR1B, TP53, RBBP8, KRAS, SMAD4
regulation of RNA biosynthetic process (GO:2001141) 1.555ACVR1B, TP53, RBBP8, KRAS, SMAD4
regulation of phosphorylation (GO:0042325) 2.55ACVR1B, TP53, STK11, KRAS, SMAD4
regulation of phosphorus metabolic process (GO:0051174) 2.355ACVR1B, TP53, STK11, KRAS, SMAD4
positive regulation of phosphorylation (GO:0042327) 2.95ACVR1B, KRAS, STK11, TP53, SMAD4
regulation of cellular protein metabolic process (GO:0032268) 1.995ACVR1B, KRAS, STK11, TP53, SMAD4
single-multicellular organism process (GO:0044707) 1.785ACVR1B, KRAS, RBBP8, TP53, SMAD4
response to stimulus (GO:0050896) 1.225RBBP8, KRAS, STK11, TP53, SMAD4
anatomical structure development (GO:0048856) 1.585ACVR1B, TP53, STK11, KRAS, SMAD4
regulation of protein phosphorylation (GO:0001932) 2.575ACVR1B, KRAS, STK11, TP53, SMAD4
regulation of transcription, DNA-templated (GO:0006355) 1.565ACVR1B, KRAS, RBBP8, TP53, SMAD4
regulation of macromolecule biosynthetic process (GO:0010556) 1.435ACVR1B, TP53, RBBP8, KRAS, SMAD4
regulation of RNA metabolic process (GO:0051252) 1.525ACVR1B, KRAS, RBBP8, TP53, SMAD4
positive regulation of protein phosphorylation (GO:0001934) 2.955ACVR1B, KRAS, STK11, TP53, SMAD4
positive regulation of cellular process (GO:0048522) 1.35ACVR1B, KRAS, STK11, TP53, SMAD4
negative regulation of growth (GO:0045926) 4.244ACVR1B, STK11, TP53, SMAD4
negative regulation of biosynthetic process (GO:0009890) 2.474RBBP8, STK11, TP53, SMAD4
cell differentiation (GO:0030154) 2.144KRAS, STK11, TP53, SMAD4
regulation of cellular component organization (GO:0051128) 2.014ACVR1B, STK11, TP53, SMAD4
negative regulation of gene expression (GO:0010629) 2.484ACVR1B, RBBP8, TP53, SMAD4
positive regulation of gene expression (GO:0010628) 2.354ACVR1B, KRAS, TP53, SMAD4
cell cycle process (GO:0022402) 2.754RBBP8, ACVR1B, STK11, TP53
cell surface receptor signaling pathway (GO:0007166) 2.094ACVR1B, STK11, KRAS, SMAD4
intracellular signal transduction (GO:0035556) 2.394KRAS, STK11, TP53, SMAD4
regulation of cell differentiation (GO:0045595) 2.424ACVR1B, STK11, KRAS, SMAD4
cellular protein metabolic process (GO:0044267) 1.634ACVR1B, STK11, KRAS, TP53
cellular response to stimulus (GO:0051716) 1.974RBBP8, STK11, TP53, SMAD4
regulation of intracellular signal transduction (GO:1902531) 2.314RBBP8, STK11, KRAS, TP53
negative regulation of macromolecule metabolic process (GO:0010605) 2.014ACVR1B, RBBP8, TP53, SMAD4
negative regulation of cell growth (GO:0030308) 4.584ACVR1B, STK11, TP53, SMAD4
cellular developmental process (GO:0048869) 1.824KRAS, STK11, TP53, SMAD4
regulation of growth (GO:0040008) 3.264ACVR1B, STK11, TP53, SMAD4
regulation of molecular function (GO:0065009) 1.784KRAS, STK11, TP53, SMAD4
regulation of cell proliferation (GO:0042127) 2.414KRAS, STK11, TP53, SMAD4
regulation of cell growth (GO:0001558) 3.754ACVR1B, STK11, TP53, SMAD4
cellular protein modification process (GO:0006464) 1.794ACVR1B, STK11, KRAS, TP53
reproductive process (GO:0022414) 2.554STK11, ACVR1B, RBBP8, SMAD4
response to stress (GO:0006950) 1.84RBBP8, STK11, TP53, SMAD4
protein modification process (GO:0036211) 1.794ACVR1B, STK11, KRAS, TP53
response to chemical (GO:0042221) 1.984KRAS, RBBP8, TP53, SMAD4
regulation of localization (GO:0032879) 1.944ACVR1B, STK11, TP53, SMAD4
response to abiotic stimulus (GO:0009628) 2.84KRAS, STK11, TP53, SMAD4
protein metabolic process (GO:0019538) 1.454ACVR1B, STK11, KRAS, TP53
macromolecule modification (GO:0043412) 1.734ACVR1B, STK11, KRAS, TP53
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.244ACVR1B, RBBP8, TP53, SMAD4
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.563ACVR1B, TP53, SMAD4
cellular component assembly (GO:0022607) 2.143STK11, TP53, SMAD4
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.473RBBP8, TP53, SMAD4
regulation of cellular localization (GO:0060341) 3.033STK11, TP53, SMAD4
positive regulation of biosynthetic process (GO:0009891) 2.293ACVR1B, TP53, SMAD4
macromolecular complex subunit organization (GO:0043933) 2.143STK11, TP53, SMAD4
response to radiation (GO:0009314) 3.693STK11, KRAS, TP53
negative regulation of cellular metabolic process (GO:0031324) 2.013RBBP8, TP53, SMAD4
apoptotic signaling pathway (GO:0097190) 4.123ACVR1B, STK11, TP53
protein phosphorylation (GO:0006468) 2.893ACVR1B, STK11, KRAS
mitotic cell cycle process (GO:1903047) 3.123ACVR1B, RBBP8, TP53
homeostatic process (GO:0042592) 2.613STK11, KRAS, SMAD4
cellular biosynthetic process (GO:0044249) 1.373RBBP8, TP53, SMAD4
cellular nitrogen compound metabolic process (GO:0034641) 1.223RBBP8, TP53, SMAD4
nitrogen compound metabolic process (GO:0006807) 1.133RBBP8, TP53, SMAD4
response to light stimulus (GO:0009416) 4.083STK11, KRAS, TP53
cellular macromolecule biosynthetic process (GO:0034645) 1.663RBBP8, TP53, SMAD4
enzyme linked receptor protein signaling pathway (GO:0007167) 3.243ACVR1B, KRAS, SMAD4
anatomical structure morphogenesis (GO:0009653) 2.533STK11, KRAS, SMAD4
organic cyclic compound biosynthetic process (GO:1901362) 1.663RBBP8, TP53, SMAD4
multicellular organism development (GO:0007275) 2.543ACVR1B, TP53, SMAD4
positive regulation of cellular protein localization (GO:1903829) 3.853STK11, TP53, SMAD4
regulation of protein localization (GO:0032880) 2.883STK11, TP53, SMAD4
nucleobase-containing compound metabolic process (GO:0006139) 1.353RBBP8, TP53, SMAD4
nucleic acid metabolic process (GO:0090304) 1.463RBBP8, TP53, SMAD4
regulation of cell death (GO:0010941) 2.433KRAS, TP53, SMAD4
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090100) 5.123ACVR1B, STK11, SMAD4
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.123RBBP8, TP53, SMAD4
positive regulation of multicellular organismal process (GO:0051240) 2.493ACVR1B, STK11, SMAD4
positive regulation of cellular biosynthetic process (GO:0031328) 2.33ACVR1B, TP53, SMAD4
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.63RBBP8, TP53, SMAD4
cellular response to stress (GO:0033554) 2.513RBBP8, STK11, TP53
macromolecular complex assembly (GO:0065003) 2.553STK11, TP53, SMAD4
phosphate-containing compound metabolic process (GO:0006796) 2.163ACVR1B, STK11, KRAS
positive regulation of immune system process (GO:0002684) 2.963ACVR1B, STK11, KRAS
regulation of immune system process (GO:0002682) 2.53ACVR1B, STK11, KRAS
organic cyclic compound metabolic process (GO:1901360) 1.263RBBP8, TP53, SMAD4
phosphorylation (GO:0016310) 2.633ACVR1B, STK11, KRAS
regulation of signal transduction by p53 class mediator (GO:1901796) 4.633RBBP8, STK11, TP53
heterocycle biosynthetic process (GO:0018130) 1.73RBBP8, TP53, SMAD4
positive regulation of cellular component organization (GO:0051130) 2.683STK11, TP53, SMAD4
negative regulation of cell proliferation (GO:0008285) 3.263STK11, TP53, SMAD4
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092) 4.393ACVR1B, STK11, SMAD4
regulation of catalytic activity (GO:0050790) 1.973STK11, KRAS, TP53
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.353ACVR1B, TP53, SMAD4
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.553RBBP8, TP53, SMAD4
organic substance biosynthetic process (GO:1901576) 1.343RBBP8, TP53, SMAD4
regulation of developmental process (GO:0050793) 2.13ACVR1B, STK11, SMAD4
negative regulation of cell death (GO:0060548) 2.953KRAS, TP53, SMAD4
protein complex assembly (GO:0006461) 2.783STK11, TP53, SMAD4
cellular aromatic compound metabolic process (GO:0006725) 1.33RBBP8, TP53, SMAD4
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.713RBBP8, TP53, SMAD4
cellular response to DNA damage stimulus (GO:0006974) 3.173RBBP8, STK11, TP53
developmental process involved in reproduction (GO:0003006) 3.363ACVR1B, STK11, SMAD4
biosynthetic process (GO:0009058) 1.323RBBP8, TP53, SMAD4
macromolecule biosynthetic process (GO:0009059) 1.613RBBP8, TP53, SMAD4
negative regulation of transcription, DNA-templated (GO:0045892) 2.753RBBP8, TP53, SMAD4
positive regulation of transcription, DNA-templated (GO:0045893) 2.563ACVR1B, TP53, SMAD4
regulation of multicellular organismal process (GO:0051239) 1.873ACVR1B, STK11, SMAD4
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.293ACVR1B, TP53, SMAD4
nucleobase-containing compound biosynthetic process (GO:0034654) 1.723RBBP8, TP53, SMAD4
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.813ACVR1B, TP53, SMAD4
response to organic substance (GO:0010033) 2.23RBBP8, KRAS, SMAD4
heterocycle metabolic process (GO:0046483) 1.313RBBP8, TP53, SMAD4
organelle organization (GO:0006996) 2.023RBBP8, KRAS, TP53
regulation of cellular protein localization (GO:1903827) 3.433STK11, TP53, SMAD4
cell cycle (GO:0007049) 3.143RBBP8, STK11, TP53
single organism reproductive process (GO:0044702) 2.733RBBP8, STK11, SMAD4
cellular nitrogen compound biosynthetic process (GO:0044271) 1.593RBBP8, TP53, SMAD4
protein complex subunit organization (GO:0071822) 2.63STK11, TP53, SMAD4
positive regulation of developmental process (GO:0051094) 2.773ACVR1B, STK11, SMAD4
negative regulation of RNA metabolic process (GO:0051253) 2.663RBBP8, TP53, SMAD4
positive regulation of cell differentiation (GO:0045597) 3.013ACVR1B, STK11, SMAD4
positive regulation of RNA metabolic process (GO:0051254) 2.513ACVR1B, TP53, SMAD4
regulation of transferase activity (GO:0051338) 2.883STK11, KRAS, TP53
positive regulation of RNA biosynthetic process (GO:1902680) 2.543ACVR1B, TP53, SMAD4
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.393ACVR1B, TP53, SMAD4
regulation of multicellular organismal development (GO:2000026) 2.313ACVR1B, STK11, SMAD4
negative regulation of RNA biosynthetic process (GO:1902679) 2.73RBBP8, TP53, SMAD4
phosphorus metabolic process (GO:0006793) 2.153ACVR1B, STK11, KRAS
negative regulation of cellular biosynthetic process (GO:0031327) 2.493RBBP8, TP53, SMAD4
aromatic compound biosynthetic process (GO:0019438) 1.73RBBP8, TP53, SMAD4
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.533RBBP8, TP53, SMAD4
regulation of intracellular protein transport (GO:0033157) 3.82TP53, SMAD4
positive regulation of intracellular transport (GO:0032388) 4.082TP53, SMAD4
cytokine-mediated signaling pathway (GO:0019221) 3.62KRAS, SMAD4
developmental growth (GO:0048589) 4.052STK11, SMAD4
anatomical structure homeostasis (GO:0060249) 4.252STK11, KRAS
regulation of transport (GO:0051049) 2.242TP53, SMAD4
regulation of intracellular transport (GO:0032386) 3.582TP53, SMAD4
regulation of reproductive process (GO:2000241) 4.882ACVR1B, STK11
G1/S transition of mitotic cell cycle (GO:0000082) 5.122ACVR1B, RBBP8
behavior (GO:0007610) 3.472KRAS, TP53
regulation of neuron apoptotic process (GO:0043523) 4.472KRAS, TP53
regulation of histone modification (GO:0031056) 4.852TP53, SMAD4
positive regulation of histone modification (GO:0031058) 5.322TP53, SMAD4
signal transduction by protein phosphorylation (GO:0023014) 3.792ACVR1B, KRAS
single-organism metabolic process (GO:0044710) 1.632ACVR1B, KRAS
negative regulation of cell cycle (GO:0045786) 3.672STK11, TP53
peptidyl-amino acid modification (GO:0018193) 2.982ACVR1B, TP53
rhythmic process (GO:0048511) 4.022TP53, SMAD4
regulation of apoptotic process (GO:0042981) 2.52KRAS, TP53
positive regulation of molecular function (GO:0044093) 2.232STK11, KRAS
transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0007178) 4.62ACVR1B, SMAD4
(GO:1905269) 5.252TP53, SMAD4
positive regulation of transport (GO:0051050) 2.92TP53, SMAD4
cell development (GO:0048468) 3.282STK11, KRAS
regulation of protein kinase activity (GO:0045859) 3.152STK11, KRAS
nucleotide-excision repair (GO:0006289) 5.052RBBP8, TP53
spermatogenesis (GO:0007283) 3.72STK11, SMAD4
growth (GO:0040007) 3.82STK11, SMAD4
neuron projection guidance (GO:0097485) 4.432KRAS, SMAD4
positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511) 6.552STK11, SMAD4
multi-organism process (GO:0051704) 2.652KRAS, TP53
immune response-activating cell surface receptor signaling pathway (GO:0002429) 4.062STK11, KRAS
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731) 4.622STK11, TP53
regulation of peptidyl-tyrosine phosphorylation (GO:0050730) 4.352STK11, TP53
positive regulation of organelle organization (GO:0010638) 3.382TP53, SMAD4
regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393) 5.632ACVR1B, SMAD4
immune system process (GO:0002376) 2.292STK11, KRAS
cell communication (GO:0007154) 3.042KRAS, TP53
embryo development ending in birth or egg hatching (GO:0009792) 4.352ACVR1B, SMAD4
positive regulation of cell development (GO:0010720) 3.572STK11, SMAD4
regulation of cell morphogenesis (GO:0022604) 3.42STK11, SMAD4
positive regulation of kinase activity (GO:0033674) 3.542STK11, KRAS
movement of cell or subcellular component (GO:0006928) 2.612KRAS, SMAD4
morphogenesis of a branching structure (GO:0001763) 4.712KRAS, SMAD4
positive regulation of protein serine/threonine kinase activity (GO:0071902) 4.062STK11, KRAS
positive regulation of protein transport (GO:0051222) 3.612TP53, SMAD4
regulation of protein transport (GO:0051223) 3.122TP53, SMAD4
signal transduction by p53 class mediator (GO:0072331) 4.882STK11, TP53
nucleic acid-templated transcription (GO:0097659) 1.912TP53, SMAD4
intrinsic apoptotic signaling pathway by p53 class mediator (GO:0072332) 5.762STK11, TP53
response to hypoxia (GO:0001666) 4.132TP53, SMAD4
positive regulation of transferase activity (GO:0051347) 3.312STK11, KRAS
immune response-regulating signaling pathway (GO:0002764) 3.722STK11, KRAS
DNA integrity checkpoint (GO:0031570) 5.252RBBP8, TP53
immune response-regulating cell surface receptor signaling pathway (GO:0002768) 3.962STK11, KRAS
regulation of kinase activity (GO:0043549) 3.072STK11, KRAS
positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862) 5.862ACVR1B, SMAD4
positive regulation of catalytic activity (GO:0043085) 2.42STK11, KRAS
transcription from RNA polymerase II promoter (GO:0006366) 3.382TP53, SMAD4
cellular response to abiotic stimulus (GO:0071214) 4.152STK11, TP53
regulation of establishment of protein localization (GO:0070201) 3.022TP53, SMAD4
regulation of transforming growth factor beta receptor signaling pathway (GO:0017015) 5.132STK11, SMAD4
cell cycle arrest (GO:0007050) 4.692STK11, TP53
programmed cell death (GO:0012501) 3.12STK11, TP53
in utero embryonic development (GO:0001701) 4.42ACVR1B, SMAD4
positive regulation of cell morphogenesis involved in differentiation (GO:0010770) 4.652STK11, SMAD4
positive regulation of intracellular signal transduction (GO:1902533) 2.952KRAS, TP53
regulation of neuron death (GO:1901214) 4.192KRAS, TP53
RNA metabolic process (GO:0016070) 1.592TP53, SMAD4
regulation of protein localization to nucleus (GO:1900180) 4.342STK11, SMAD4
immune response-activating signal transduction (GO:0002757) 3.82STK11, KRAS
response to decreased oxygen levels (GO:0036293) 4.092TP53, SMAD4
positive regulation of nucleocytoplasmic transport (GO:0046824) 4.932TP53, SMAD4
regulation of nucleocytoplasmic transport (GO:0046822) 4.332TP53, SMAD4
transcription, DNA-templated (GO:0006351) 1.912TP53, SMAD4
positive regulation of chromosome organization (GO:2001252) 4.762TP53, SMAD4
regulation of chromosome organization (GO:0033044) 4.112TP53, SMAD4
cellular response to light stimulus (GO:0071482) 5.222STK11, TP53
RNA biosynthetic process (GO:0032774) 1.842TP53, SMAD4
regulation of organelle organization (GO:0033043) 2.722TP53, SMAD4
chemical homeostasis (GO:0048878) 2.972STK11, SMAD4
embryo development (GO:0009790) 4.22ACVR1B, SMAD4
response to UV (GO:0009411) 4.882STK11, TP53
cellular response to chemical stimulus (GO:0070887) 2.572TP53, SMAD4
cellular response to UV (GO:0034644) 5.522STK11, TP53
axon guidance (GO:0007411) 4.442KRAS, SMAD4
positive regulation of establishment of protein localization (GO:1904951) 3.492TP53, SMAD4
protein autophosphorylation (GO:0046777) 4.462ACVR1B, STK11
response to organic cyclic compound (GO:0014070) 3.072RBBP8, KRAS
response to endogenous stimulus (GO:0009719) 2.792KRAS, SMAD4
regulation of cellular response to growth factor stimulus (GO:0090287) 4.292STK11, SMAD4
cellular response to radiation (GO:0071478) 4.812STK11, TP53
response to ionizing radiation (GO:0010212) 4.742STK11, TP53
regulation of anatomical structure morphogenesis (GO:0022603) 2.792STK11, SMAD4
regulation of cell development (GO:0060284) 3.012STK11, SMAD4
regulation of cell morphogenesis involved in differentiation (GO:0010769) 3.912STK11, SMAD4
chordate embryonic development (GO:0043009) 4.382ACVR1B, SMAD4
response to oxygen levels (GO:0070482) 4.022TP53, SMAD4
positive regulation of cell proliferation (GO:0008284) 3.012KRAS, SMAD4
tube morphogenesis (GO:0035239) 4.352KRAS, SMAD4
multicellular organismal reproductive process (GO:0048609) 3.352STK11, SMAD4
cell proliferation (GO:0008283) 3.232TP53, SMAD4
positive regulation of protein localization to nucleus (GO:1900182) 4.872STK11, SMAD4
male gamete generation (GO:0048232) 3.72STK11, SMAD4
tissue homeostasis (GO:0001894) 4.782STK11, KRAS
regulation of immune response (GO:0050776) 2.982STK11, KRAS
positive regulation of immune response (GO:0050778) 3.42STK11, KRAS
system development (GO:0048731) 2.922ACVR1B, STK11
positive regulation of protein kinase activity (GO:0045860) 3.612STK11, KRAS
regulation of chromatin organization (GO:1902275) 4.692TP53, SMAD4
branching morphogenesis of an epithelial tube (GO:0048754) 4.932KRAS, SMAD4
intrinsic apoptotic signaling pathway (GO:0097193) 4.692STK11, TP53
cell cycle phase transition (GO:0044770) 4.242ACVR1B, RBBP8
mitotic cell cycle phase transition (GO:0044772) 4.272ACVR1B, RBBP8
cell death (GO:0008219) 3.052STK11, TP53
gamete generation (GO:0007276) 3.612STK11, SMAD4
morphogenesis of an epithelium (GO:0002009) 4.082KRAS, SMAD4
regulation of protein serine/threonine kinase activity (GO:0071900) 3.582STK11, KRAS
regulation of cellular response to transforming growth factor beta stimulus (GO:1903844) 5.132STK11, SMAD4
positive regulation of cellular response to transforming growth factor beta stimulus (GO:1903846) 6.552STK11, SMAD4
response to lipid (GO:0033993) 3.112RBBP8, KRAS
DNA repair (GO:0006281) 3.592RBBP8, TP53
cellular component morphogenesis (GO:0032989) 3.52STK11, SMAD4
regulation of programmed cell death (GO:0043067) 2.492KRAS, TP53
negative regulation of apoptotic process (GO:0043066) 3.042KRAS, TP53
tissue morphogenesis (GO:0048729) 3.872KRAS, SMAD4
negative regulation of programmed cell death (GO:0043069) 3.022KRAS, TP53
morphogenesis of a branching epithelium (GO:0061138) 4.772KRAS, SMAD4
apoptotic process (GO:0006915) 3.142STK11, TP53
positive regulation of intracellular protein transport (GO:0090316) 4.192TP53, SMAD4
cell cycle G1/S phase transition (GO:0044843) 5.122ACVR1B, RBBP8
Ras protein signal transduction (GO:0007265) 4.762KRAS, TP53
small GTPase mediated signal transduction (GO:0007264) 3.852KRAS, TP53
localization (GO:0051179) 1.42STK11, TP53
cellular localization (GO:0051641) 2.322STK11, TP53
DNA damage checkpoint (GO:0000077) 5.372RBBP8, TP53
cell cycle checkpoint (GO:0000075) 4.792RBBP8, TP53
regulation of cell cycle (GO:0051726) 2.932STK11, TP53
single-organism organelle organization (GO:1902589) 2.682KRAS, TP53
activation of immune response (GO:0002253) 3.672STK11, KRAS
DNA metabolic process (GO:0006259) 3.092RBBP8, TP53

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of extrinsic apoptotic signaling pathway (GO:2001236) NEW4.690.023KRAS, STK11, TP53, SMAD4
regulation of activin receptor signaling pathway (GO:0032925) NEW6.510.0ACVR1B, TP53, SMAD4
positive regulation of response to stimulus (GO:0048584) -2.180.029ACVR1B, KRAS, STK11, TP53, SMAD4
cell development (GO:0048468) -3.280.005TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
alpha-beta T cell differentiation (GO:0046632) NEW6.150.015KRAS, TP53, SMAD4
alpha-beta T cell activation (GO:0046631) NEW5.920.023KRAS, TP53, SMAD4
skeletal system development (GO:0001501) NEW4.490.041ACVR1B, TP53, KRAS, SMAD4
enzyme linked receptor protein signaling pathway (GO:0007167) -3.240.001ACVR1B, TP53, STK11, KRAS, SMAD4
signal transduction by phosphorylation (GO:0023014) -3.790.0ACVR1B, KRAS, STK11, TP53, SMAD4
positive regulation of signal transduction (GO:0009967) -2.50.003ACVR1B, TP53, STK11, KRAS, SMAD4
gastrulation (GO:0007369) NEW5.90.015ACVR1B, TP53, SMAD4
MAPK cascade (GO:0000165) NEW3.910.018KRAS, STK11, TP53, SMAD4
development of primary sexual characteristics (GO:0045137) NEW7.530.011ACVR1B, SMAD4
epithelial cell differentiation (GO:0030855) NEW3.980.008ACVR1B, KRAS, STK11, TP53, SMAD4
G1/S transition of mitotic cell cycle (GO:0000082) -5.120.002ACVR1B, RBBP8, TP53, SMAD4
monocarboxylic acid metabolic process (GO:0032787) NEW3.570.034ACVR1B, TP53, STK11, KRAS, SMAD4
negative regulation of histone deacetylation (GO:0031064) NEW8.120.011TP53, SMAD4
positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511) -6.550.021STK11, TP53, SMAD4
transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0007178) -4.60.02ACVR1B, TP53, SMAD4
regulation of phosphorylation (GO:0042325) -2.50.005ACVR1B, TP53, STK11, KRAS, SMAD4
positive regulation of phosphorylation (GO:0042327) -2.90.001ACVR1B, TP53, STK11, KRAS, SMAD4
regulation of peptidyl-tyrosine phosphorylation (GO:0050730) -4.350.045KRAS, STK11, TP53, SMAD4
negative regulation of epithelial cell proliferation (GO:0050680) NEW4.980.006KRAS, STK11, TP53, SMAD4
negative regulation of transporter activity (GO:0032410) NEW5.590.015STK11, TP53, SMAD4
regulation of anatomical structure morphogenesis (GO:0022603) -2.790.02TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862) -5.860.027ACVR1B, SMAD4
developmental maturation (GO:0021700) NEW4.70.045ACVR1B, KRAS, TP53, SMAD4
response to purine-containing compound (GO:0014074) NEW4.670.017ACVR1B, KRAS, TP53, SMAD4
peptide hormone secretion (GO:0030072) NEW5.690.043KRAS, TP53, SMAD4
G2 DNA damage checkpoint (GO:0031572) NEW6.260.003RBBP8, STK11, TP53
cell morphogenesis (GO:0000902) NEW4.350.001ACVR1B, KRAS, STK11, TP53, SMAD4
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090100) -5.120.001ACVR1B, STK11, TP53, SMAD4
anatomical structure formation involved in morphogenesis (GO:0048646) NEW3.010.022TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
development of primary female sexual characteristics (GO:0046545) NEW8.120.007ACVR1B, SMAD4
regulation of developmental process (GO:0050793) -2.10.041ACVR1B, KRAS, STK11, TP53, SMAD4
regulation of transforming growth factor beta receptor signaling pathway (GO:0017015) -5.130.003KRAS, STK11, TP53, SMAD4
positive regulation of MAPK cascade (GO:0043410) NEW3.570.014ACVR1B, KRAS, STK11, TP53, SMAD4
somatic stem cell maintenance (GO:0035019) NEW5.520.03KRAS, TP53, SMAD4
regulation of protein localization to nucleus (GO:1900180) -4.340.028ACVR1B, KRAS, TP53, SMAD4
positive regulation of protein modification process (GO:0031401) -2.70.001ACVR1B, KRAS, STK11, TP53, SMAD4
cell maturation (GO:0048469) NEW4.980.011ACVR1B, TP53, KRAS, SMAD4
negative regulation of cell motility (GO:2000146) NEW4.360.046ACVR1B, TP53, KRAS, SMAD4
regulation of myeloid cell differentiation (GO:0045637) NEW4.560.031ACVR1B, TP53, KRAS, SMAD4
fatty acid biosynthetic process (GO:0006633) NEW5.010.003ACVR1B, STK11, KRAS, TP53
regulation of developmental growth (GO:0048638) NEW4.040.032ACVR1B, KRAS, TP53, SMAD4
negative regulation of cell growth (GO:0030308) -4.580.0ACVR1B, KRAS, STK11, TP53, SMAD4
mesoderm development (GO:0007498) NEW5.720.0ACVR1B, RBBP8, TP53, SMAD4
stress-activated protein kinase signaling cascade (GO:0031098) NEW5.410.0KRAS, STK11, TP53, SMAD4
positive regulation of signaling (GO:0023056) -2.410.004ACVR1B, TP53, STK11, KRAS, SMAD4
positive regulation of MAP kinase activity (GO:0043406) NEW4.390.045KRAS, STK11, TP53, SMAD4
embryo development ending in birth or egg hatching (GO:0009792) -4.350.033ACVR1B, TP53, SMAD4
embryonic foregut morphogenesis (GO:0048617) NEW7.530.043TP53, SMAD4
positive regulation of cell communication (GO:0010647) -2.410.004ACVR1B, TP53, STK11, KRAS, SMAD4
regulation of cellular response to growth factor stimulus (GO:0090287) -4.290.014STK11, TP53, SMAD4
in utero embryonic development (GO:0001701) -4.40.029ACVR1B, TP53, SMAD4
positive regulation of phosphorus metabolic process (GO:0010562) -2.780.001ACVR1B, TP53, STK11, KRAS, SMAD4
cell fate determination (GO:0001709) NEW5.970.02STK11, TP53, SMAD4
vasculature development (GO:0001944) NEW6.040.011ACVR1B, STK11, SMAD4
positive regulation of protein metabolic process (GO:0051247) -2.430.003ACVR1B, TP53, STK11, KRAS, SMAD4
heart looping (GO:0001947) NEW5.650.04ACVR1B, TP53, SMAD4
regulation of transporter activity (GO:0032409) NEW4.450.019KRAS, STK11, TP53, SMAD4
positive regulation of cellular protein metabolic process (GO:0032270) -2.490.002ACVR1B, KRAS, STK11, TP53, SMAD4
regulation of protein modification process (GO:0031399) -2.320.007ACVR1B, TP53, STK11, KRAS, SMAD4
chordate embryonic development (GO:0043009) -4.380.031ACVR1B, TP53, SMAD4
mesoderm morphogenesis (GO:0048332) NEW8.120.017TP53, SMAD4
regulation of cell differentiation (GO:0045595) -2.420.008ACVR1B, TP53, STK11, KRAS, SMAD4
regulation of cell growth (GO:0001558) -3.750.001ACVR1B, KRAS, STK11, TP53, SMAD4
regulation of cellular protein metabolic process (GO:0032268) -1.990.022ACVR1B, KRAS, STK11, TP53, SMAD4
regulation of epithelial cell proliferation (GO:0050678) NEW4.060.006ACVR1B, KRAS, STK11, TP53, SMAD4
negative regulation of growth (GO:0045926) -4.240.0ACVR1B, TP53, STK11, KRAS, SMAD4
cell cycle phase transition (GO:0044770) -4.240.038ACVR1B, RBBP8, TP53, SMAD4
mitotic cell cycle phase transition (GO:0044772) -4.270.036ACVR1B, RBBP8, TP53, SMAD4
cell cycle process (GO:0022402) -2.750.016TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
cellular response to insulin stimulus (GO:0032869) NEW5.290.032KRAS, STK11, TP53, SMAD4
cell cycle arrest (GO:0007050) -4.690.007KRAS, STK11, TP53, SMAD4
regulation of growth (GO:0040008) -3.260.011ACVR1B, STK11, TP53, SMAD4
spleen development (GO:0048536) NEW6.070.007KRAS, TP53, SMAD4
response to organophosphorus (GO:0046683) NEW4.790.012ACVR1B, KRAS, TP53, SMAD4
negative regulation of cell migration (GO:0030336) NEW4.410.044ACVR1B, KRAS, TP53, SMAD4
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092) -4.390.031ACVR1B, STK11, TP53, SMAD4
pericardium development (GO:0060039) NEW7.530.048TP53, SMAD4
positive regulation of phosphate metabolic process (GO:0045937) -2.780.001ACVR1B, KRAS, STK11, TP53, SMAD4
stress-activated MAPK cascade (GO:0051403) NEW5.450.0KRAS, STK11, TP53, SMAD4
cell cycle G1/S phase transition (GO:0044843) -5.120.002ACVR1B, RBBP8, TP53, SMAD4
DNA damage checkpoint (GO:0000077) -5.370.047RBBP8, STK11, TP53
cell cycle checkpoint (GO:0000075) -4.790.007STK11, RBBP8, TP53, SMAD4
regulation of protein phosphorylation (GO:0001932) -2.570.002ACVR1B, KRAS, STK11, TP53, SMAD4
positive regulation of protein phosphorylation (GO:0001934) -2.950.0ACVR1B, KRAS, STK11, TP53, SMAD4
negative regulation of cellular process (GO:0048523) -1.410.034TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.116TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
membrane-bounded organelle (GO:0043227) 0.476TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
organelle (GO:0043226) 0.46TP53, STK11, KRAS, RBBP8, SMAD4, ACVR1B
protein complex (GO:0043234) 1.515RBBP8, ACVR1B, STK11, TP53, SMAD4
intracellular part (GO:0044424) 0.285RBBP8, KRAS, STK11, TP53, SMAD4
intracellular organelle (GO:0043229) 0.515RBBP8, KRAS, STK11, TP53, SMAD4
macromolecular complex (GO:0032991) 1.355RBBP8, ACVR1B, STK11, TP53, SMAD4
intracellular membrane-bounded organelle (GO:0043231) 0.65RBBP8, KRAS, STK11, TP53, SMAD4
cytoplasm (GO:0005737) 1.014KRAS, STK11, TP53, SMAD4
intracellular organelle part (GO:0044446) 0.814RBBP8, STK11, TP53, SMAD4
nucleus (GO:0005634) 1.074RBBP8, STK11, TP53, SMAD4
membrane (GO:0016020) 0.684ACVR1B, STK11, TP53, KRAS
nucleoplasm (GO:0005654) 1.894RBBP8, STK11, TP53, SMAD4
cytoplasmic part (GO:0044444) 0.824KRAS, STK11, TP53, SMAD4
nuclear part (GO:0044428) 1.554RBBP8, STK11, TP53, SMAD4
cytosol (GO:0005829) 1.684KRAS, STK11, TP53, SMAD4
organelle part (GO:0044422) 0.794RBBP8, STK11, TP53, SMAD4
membrane part (GO:0044425) 0.953ACVR1B, TP53, KRAS
mitochondrion (GO:0005739) 2.423STK11, KRAS, TP53
intracellular (GO:0005622) 2.372KRAS, SMAD4
extracellular organelle (GO:0043230) 1.892ACVR1B, STK11
extracellular exosome (GO:0070062) 1.892ACVR1B, STK11
intracellular non-membrane-bounded organelle (GO:0043232) 1.762RBBP8, TP53
nucleolus (GO:0005730) 3.062RBBP8, TP53
integral component of membrane (GO:0016021) 1.142ACVR1B, TP53
plasma membrane (GO:0005886) 1.392ACVR1B, KRAS
nuclear transcription factor complex (GO:0044798) 4.952TP53, SMAD4
membrane-bounded vesicle (GO:0031988) 1.712ACVR1B, STK11
nuclear chromosome part (GO:0044454) 3.672TP53, SMAD4
RNA polymerase II transcription factor complex (GO:0090575) 5.182TP53, SMAD4
non-membrane-bounded organelle (GO:0043228) 1.762RBBP8, TP53
chromatin (GO:0000785) 3.992TP53, SMAD4
chromosomal part (GO:0044427) 3.182TP53, SMAD4
transcription factor complex (GO:0005667) 4.12TP53, SMAD4
nuclear chromatin (GO:0000790) 4.422TP53, SMAD4
extracellular vesicle (GO:1903561) 1.892ACVR1B, STK11
plasma membrane part (GO:0044459) 1.952ACVR1B, KRAS
extracellular region part (GO:0044421) 1.572ACVR1B, STK11
intrinsic component of membrane (GO:0031224) 1.132ACVR1B, TP53
vesicle (GO:0031982) 1.642ACVR1B, STK11

NET-GE enrichment

Term New enriched termICP valueGenes
endocytic vesicle (GO:0030139) NEW5.040.018KRAS, TP53, SMAD4
focal adhesion (GO:0005925) NEW3.830.02KRAS, RBBP8, TP53, SMAD4
transcriptional repressor complex (GO:0017053) NEW5.370.002RBBP8, TP53, SMAD4
Golgi apparatus (GO:0005794) NEW2.70.044ACVR1B, TP53, STK11, KRAS, SMAD4
protein kinase complex (GO:1902911) NEW5.310.003STK11, KRAS, TP53
anchoring junction (GO:0070161) NEW3.610.049KRAS, RBBP8, TP53, SMAD4
endosome membrane (GO:0010008) NEW3.830.038ACVR1B, KRAS, TP53, SMAD4
cell cortex part (GO:0044448) NEW5.010.016KRAS, TP53, SMAD4
adherens junction (GO:0005912) NEW3.660.043KRAS, RBBP8, TP53, SMAD4
endosomal part (GO:0044440) NEW3.730.046ACVR1B, TP53, KRAS, SMAD4
cell-substrate adherens junction (GO:0005924) NEW3.830.023KRAS, RBBP8, TP53, SMAD4
nuclear matrix (GO:0016363) NEW5.220.024KRAS, TP53, SMAD4
early endosome membrane (GO:0031901) NEW5.060.018ACVR1B, TP53, SMAD4
cell-substrate junction (GO:0030055) NEW3.820.023KRAS, RBBP8, TP53, SMAD4