Disease table of MICROCEPHALY, PRIMARY AUTOSOMAL RECESSIVE OMIM ID: PS251200

Gene-disease associations table

GeneAssociated with MICROCEPHALY, PRIMARY AUTOSOMAL RECESSIVE inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
MCPH1ClinVar, OMIM, HUMSAVARHGNC link8p23.11PS251200
CEP152ClinVar, OMIM, HUMSAVARHGNC link15q21.12PS251200, PS210600
ZNF335ClinVar, OMIM, HUMSAVARHGNC link20q13.121PS251200
CENPJClinVar, OMIM, HUMSAVARHGNC link13q12.132PS251200, PS210600
STILClinVar, OMIM, HUMSAVARHGNC link1p331PS251200
ASPMClinVar, OMIM, HUMSAVARHGNC link1q31.31PS251200
CENPEClinVar, OMIM, HUMSAVARHGNC link4q241PS251200
MFSD2AOMIM, HUMSAVARHGNC link1p34.21PS251200
CEP135OMIMHGNC link4q121PS251200
CDK5RAP2ClinVar, OMIMHGNC link9q33.22217990, PS251200
ANKLE2ClinVar, OMIMHGNC link12q24.331PS251200
PHC1ClinVar, OMIM, HUMSAVARHGNC link12p13.311PS251200
CASC5ClinVar, OMIM, HUMSAVARHGNC link15q15.11PS251200
CDK6ClinVar, OMIM, HUMSAVARHGNC link7q21.21PS251200
WDR62ClinVar, OMIM, HUMSAVARHGNC link19q13.121PS251200
SASS6ClinVar, OMIM, HUMSAVARHGNC link1p21.21PS251200

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
1p32STIL, MFSD2A
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
15q2CASC5, CEP152
1p3STIL, MFSD2A, SASS6
4q2CEP135, CENPE
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
122ANKLE2, PHC1
152CASC5, CEP152
14STIL, ASPM, SASS6, MFSD2A
42CEP135, CENPE
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
MCPH1YES1E2F10
ASPMYES2FOXJ1, BRCA10
MFSD2AYES3AHR, ARNT, GCM10
CDK6YES10SP1, AR, RELA, NR3C1, TCF3, NFKB2, NANOG, ZNF382, MYC, MYCN0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
MCPH1CDK6No1MCM2
CEP152CENPJYes35CEP85, SMG7, HAUS8, ALMS1, HAUS3, ATXN10, TCHP, PALLD, CEP120, YWHAH, OFD1, TNRC6B, GPX1, NEDD1, FAM21A, PCNT, CCDC138, SDCCAG3, CEP192, CNOT1, TNIP1, ADSL, KIAA1671, SASS6, PCM1, GPATCH1, KIF14, HAUS6, TNRC6A, TP53BP2, XRN1, KIAA0753, CEP131, CNOT10, TTK
CEP152STILNo18NEDD1, GPATCH1, TCHP, WDR83, CEP85, SMG7, SDCCAG3, TBK1, CC2D1A, XRN1, CENPJ, AP3M1, OFD1, CNOT3, TNRC6B, SASS6, PLK4, PCM1
CEP152ASPMNo2SDCCAG3, TP53
CEP152CENPENo3OFD1, CEP131, PCM1
CEP152CEP135Yes44TXLNA, WDR83, CEP85, HAUS8, FGFR1OP, ALMS1, TJP1, HAUS3, NDEL1, SIPA1L3, CC2D1A, YWHAH, CEP128, TTK, LUZP1, OFD1, PCM1, ARHGAP21, ERC1, GYS1, NEDD1, TNRC6B, CCDC138, SDCCAG3, TCHP, CEP350, TNIP1, TP53, ADSL, KIAA1671, DLG5, GPATCH1, KIF14, CEP120, HAUS6, TNRC6A, MED4, TP53BP2, XRN1, KIAA0753, CEP131, CEP192, TBK1, ECH1
CEP152CDK5RAP2Yes7CEP192, DYNLL1, RPGRIP1L, FGFR1OP, PCNT, TUBGCP2, PLK4
CEP152CASC5No2TTK, CEP120
CEP152WDR62No1YWHAH
CEP152SASS6Yes26TTC28, HAUS8, FGFR1OP, GPATCH1, TJP1, HAUS3, CEP192, HAUS2, PLK4, RAE1, OFD1, PCM1, TNRC6B, ERC1, NEDD1, FAM21A, CCDC138, SDCCAG3, CENPJ, KIAA1671, DLG5, ALMS1, HAUS6, MED4, CEP131, TBK1
ZNF335ASPMNo1CDK4
ZNF335CEP135No1CDK4
ZNF335CDK6Yes2CDK6, CDK4
CENPJSTILYes24BTF3, SMG7, SSX2IP, MB21D2, GPATCH1, TCHP, HAUS7, OFD1, TNRC6B, DVL3, UNC45A, NEDD1, SDCCAG3, SEC23B, ABLIM1, CEP85, SASS6, PCM1, TPGS1, DCP1B, LRRC49, PFDN4, XRN1, VCPIP1
CENPJASPMNo2SDCCAG3, HAUS7
CENPJCENPENo5OFD1, YWHAE, CEP131, PCM1, CLASP2
CENPJCEP135No48SPICE1, CEP85, HAUS7, HAUS8, CEP170, ALMS1, CCP110, HAUS3, WRAP73, KIF7, TCHP, YWHAH, MPHOSPH9, TTK, HAUS1, KIAA0753, OFD1, TNRC6B, DVL3, CEP55, SSX2IP, LZTS2, NEDD1, CEP152, CEP131, CCDC138, SDCCAG3, IBTK, TPGS1, TNIP1, ADSL, KIAA1671, PCM1, GPATCH1, KIF14, CEP120, HAUS6, TNRC6A, TP53BP2, XRN1, PLK1, CAMSAP1, MIB1, CEP97, CSPP1, C2CD3, CEP192, LRRC49
CENPJCDK5RAP2No4CEP152, PCNT, TUBG1, CEP192
CENPJCASC5No2TTK, CEP120
CENPJCDK6No1PPHLN1
CENPJWDR62No5CEP170, YWHAH, YWHAG, YWHAB, YWHAZ
CENPJSASS6Yes27HAUS7, SSX2IP, CEP152, GPATCH1, CCP110, HAUS3, CEP192, HAUS1, OFD1, TNRC6B, HAUS8, UNC45A, NEDD1, FAM21A, CCDC138, SDCCAG3, NINL, STIL, KIAA1671, CEP170, PCM1, ALMS1, HAUS6, LRRC49, WRAP73, CEP97, CEP131
STILASPMNo2SDCCAG3, HAUS7
STILCENPENo3OFD1, CUL1, PCM1
STILCEP135No22WDR83, SSX2IP, ERVK3-1, GPATCH1, TCHP, NME7, HAUS7, OFD1, TNRC6B, DVL3, TRIP6, NEDD1, SDCCAG3, CC2D1A, MAGED1, CEP85, PCM1, TPGS1, LRRC49, XRN1, TBK1, GTPBP1
STILCDK5RAP2No3PLK4, PRPS1, NME7
STILCASC5No1FBXW11
STILCDK6No1CDC37
STILWDR62No3MAPK9, FBXW11, BAG2
STILSASS6Yes13NEDD1, GPATCH1, SDCCAG3, TBK1, HAUS7, CENPJ, LRRC49, OFD1, PCM1, TNRC6B, PLK4, SSX2IP, UNC45A
ASPMCENPENo1TP63
ASPMCEP135No4SDCCAG3, HAUS7, TP53, CDK4
ASPMCDK5RAP2No1DTNBP1
ASPMCASC5No2NDC80, SPC24
ASPMCDK6No2NUMA1, CDK4
ASPMWDR62No1HERC2
ASPMSASS6No3SDCCAG3, TP73, HAUS7
CENPECEP135No3OFD1, CEP131, PCM1
CENPEPHC1No3CBX2, PPP1CA, CBX4
CENPECASC5No4NUF2, BUB1B, PPP1CA, BUB1
CENPESASS6No3OFD1, CEP131, PCM1
CEP135CDK5RAP2No7CEP152, NME7, CEP192, FGFR1OP, MAPRE1, CARD9, C17ORF59
CEP135PHC1No1CBX6
CEP135CASC5No2TTK, CEP120
CEP135CDK6No2CDK4, TJP2
CEP135WDR62No3CEP44, YWHAH, CEP170
CEP135SASS6No37HAUS4, HAUS7, SSX2IP, CEP152, FGFR1OP, ALMS1, CCP110, HAUS3, WRAP73, C17ORF59, HAUS8, KEAP1, CEP192, HAUS1, OFD1, PCM1, TNRC6B, ERC1, TBK1, SQSTM1, NEDD1, CEP170, ISOC1, CCDC138, SDCCAG3, KIAA1671, DLG5, GPATCH1, HAUS6, MED4, PIBF1, TJP1, DVL2, CEP97, CEP131, LRRC49, MTPN
CDK5RAP2CASC5No1MLF1
CDK5RAP2CDK6No1CDK5R1
CDK5RAP2SASS6No5CEP152, PLK4, FGFR1OP, C17ORF59, CEP192
ANKLE2CDK6No3NTRK1, KIF26B, PPP2CA
ANKLE2SASS6No1RTEL1
PHC1CASC5No2PPP1CC, PPP1CA
PHC1CDK6No1ELAVL1
CASC5CDK6No1PML
CASC5WDR62No1FBXW11
CDK6SASS6No1SRSF2
WDR62SASS6No1CEP170

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
MCPH1CASC5No1KRAS
STILCDK5RAP2No1MUS81

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
MCPH1PHC1No-1CDC27
MCPH1CDK6No-4SMC2, H2AFX, CDC27, E2F1
CEP152CENPJYesbinding64TUBGCP5, CDK1, CDK5RAP2, CEP57, CSNK1E, SSNA1, ACTR1A, YWHAE, CEP76, CEP70, ALMS1, CSNK1D, PLK1, CEP135, MAPRE1, TUBA4A, TUBGCP6, PRKACA, ODF2, HSP90AA1, CEP192, SFI1, HAUS2, CEP250, DYNLL1, OFD1, CNTRL, DYNC1H1, TUBA1A, DYNC1I2, PCM1, PCNT, TUBGCP2, AZI1, CEP164, NEDD1, CEP63, CCP110, DCTN3, CKAP5, SDCCAG8, PRKAR2B, TUBB4B, CEP78, TUBGCP3, NINL, PAFAH1B1, FGFR1OP, PPP2R1A, BORA, CEP290, DCTN2, AJUBA, AURKA, CLASP1, NEK2, TUBGCP4, CEP72, YWHAG, TUBG2, TUBB4A, PLK4, NDE1, TUBG1
CEP152STILNo-1CENPJ
CEP152CENPENo-9CDK1, PAFAH1B1, DYNC1H1, CKAP5, AURKA, MAPRE1, PLK1, CLASP1, NDE1
CEP152CEP135Yesbinding64TUBGCP5, CDK1, CDK5RAP2, CEP57, CSNK1E, SSNA1, ACTR1A, YWHAE, CEP76, CEP70, ALMS1, CSNK1D, PLK1, TUBG1, MAPRE1, TUBA4A, TUBGCP6, PRKACA, ODF2, HSP90AA1, CEP192, SFI1, DCTN2, CEP250, DYNLL1, OFD1, CNTRL, DYNC1H1, TUBA1A, DYNC1I2, PCM1, PCNT, TUBGCP2, AZI1, CEP164, NEDD1, CEP63, CCP110, DCTN3, CKAP5, SDCCAG8, PRKAR2B, TUBB4B, CEP78, CENPJ, NINL, PAFAH1B1, FGFR1OP, PPP2R1A, BORA, TUBGCP3, CEP290, HAUS2, AJUBA, AURKA, CLASP1, NEK2, TUBGCP4, CEP72, YWHAG, TUBG2, TUBB4A, PLK4, NDE1
CEP152CDK5RAP2Yesbinding64TUBGCP5, CDK1, CEP57, CSNK1E, SSNA1, ACTR1A, YWHAE, CEP76, CEP70, ALMS1, CSNK1D, PLK1, CEP135, MAPRE1, TUBA4A, TUBGCP6, PRKACA, ODF2, HSP90AA1, CEP192, SFI1, HAUS2, CEP250, DYNLL1, OFD1, CNTRL, DYNC1H1, TUBA1A, DYNC1I2, PCM1, PCNT, TUBGCP2, AZI1, CEP164, NEDD1, CEP63, CCP110, DCTN3, CKAP5, SDCCAG8, PRKAR2B, TUBB4B, CEP78, CENPJ, NINL, PAFAH1B1, FGFR1OP, PPP2R1A, BORA, TUBGCP3, CEP290, DCTN2, AJUBA, AURKA, CLASP1, NEK2, TUBGCP4, CEP72, YWHAG, TUBG2, TUBB4A, PLK4, NDE1, TUBG1
CEP152ANKLE2No-1PPP2R1A
CEP152CASC5No-6PAFAH1B1, CKAP5, MAPRE1, PLK1, CLASP1, NDE1
CEP152CDK6No-2CDK1, HSP90AA1
CEP152SASS6No-1CENPJ
CENPJSTILYesbinding0
CENPJCENPENo-9CDK1, PAFAH1B1, DYNC1H1, CKAP5, AURKA, MAPRE1, PLK1, CLASP1, NDE1
CENPJCEP135Yesbinding64CEP76, TUBGCP5, CDK1, CDK5RAP2, CEP57, CSNK1E, SSNA1, ACTR1A, YWHAE, CEP152, CEP70, ALMS1, CSNK1D, PLK1, TUBG1, MAPRE1, TUBA4A, TUBGCP6, PRKACA, ODF2, HSP90AA1, CEP192, SFI1, DCTN2, CEP250, DYNLL1, OFD1, CNTRL, DYNC1H1, TUBA1A, DYNC1I2, PCM1, PCNT, TUBGCP2, AZI1, CEP164, NEDD1, CEP63, CCP110, DCTN3, CKAP5, SDCCAG8, PRKAR2B, TUBB4B, CEP78, TUBGCP3, NINL, PAFAH1B1, FGFR1OP, PPP2R1A, BORA, CEP290, HAUS2, AJUBA, AURKA, CLASP1, NEK2, TUBGCP4, CEP72, YWHAG, TUBG2, TUBB4A, PLK4, NDE1
CENPJCDK5RAP2Yesbinding64CEP76, TUBGCP5, CDK1, CEP57, CSNK1E, SSNA1, ACTR1A, YWHAE, CEP152, CEP70, ALMS1, CSNK1D, PLK1, CEP135, MAPRE1, TUBA4A, TUBGCP6, PRKACA, ODF2, HSP90AA1, CEP192, SFI1, HAUS2, CEP250, DYNLL1, OFD1, CNTRL, DYNC1H1, TUBA1A, DYNC1I2, PCM1, PCNT, TUBGCP2, AZI1, CEP164, NEDD1, CEP63, CCP110, DCTN3, CKAP5, SDCCAG8, PRKAR2B, TUBB4B, CEP78, TUBGCP3, NINL, PAFAH1B1, FGFR1OP, PPP2R1A, BORA, CEP290, DCTN2, AJUBA, AURKA, CLASP1, NEK2, TUBGCP4, CEP72, YWHAG, TUBG2, TUBB4A, PLK4, NDE1, TUBG1
CENPJANKLE2No-1PPP2R1A
CENPJPHC1No-1BRCA1
CENPJCASC5No-6PAFAH1B1, CKAP5, MAPRE1, PLK1, CLASP1, NDE1
CENPJCDK6No-2CDK1, HSP90AA1
CENPJSASS6Yesbinding1TMEM35
STILASPMNo-1UBC
STILCENPENo-1UBC
STILCEP135No-1CENPJ
STILCDK5RAP2No-2CENPJ, UBC
STILCASC5No-1UBC
STILCDK6No-1UBC
STILSASS6No-1CENPJ
ASPMCENPENo-1UBC
ASPMCDK5RAP2No-1UBC
ASPMCASC5No-1UBC
ASPMCDK6No-1UBC
CENPECEP135No-9CDK1, PAFAH1B1, DYNC1H1, CKAP5, AURKA, MAPRE1, PLK1, CLASP1, NDE1
CENPECDK5RAP2No-11CDK1, PAFAH1B1, DYNC1H1, CKAP5, AURKA, MAPRE1, PLK1, CLASP1, UBC, CDC20, NDE1
CENPEPHC1No-1BUB1B
CENPECASC5Yesbinding82CENPA, NDC80, STAG1, CDCA8, PDS5A, BUB1B, NUP37, CKAP5, BIRC5, XPO1, CENPQ, CENPN, MAD2L1, STAG2, DSN1, CENPI, NDEL1, CENPO, KIF2C, AURKB, KIF18A, NUP85, TAOK1, CLASP2, CENPC1, SEC13, PAFAH1B1, PMF1, KIF2A, CENPL, SKA2, NSL1, CENPF, MAPRE1, PDS5B, NUDC, CLIP1, ESPL1, RAD21, NUP43, MLF1IP, B9D2, APITD1, NUP133, INCENP, CENPM, KNTC1, SPC24, NUP107, CENPT, BUB3, RCC2, CDCA5, SMC3, BUB1, SGOL1, ZWILCH, PPP1CC, MAD1L1, RANGAP1, NUF2, ERCC6L, AHCTF1, RPS27, KIF2B, CLASP1, PLK1, CENPP, ZWINT, ZW10, CENPK, SPDL1, ITGB3BP, RANBP2, CDC20, UBC, CENPH, NUP160, WAPAL, MIS12, SGOL2, NDE1
CENPECDK6No-5UBC, CDK1, CDC20, CCNB1, CDK2
CEP135CDK5RAP2Yesbinding64CEP76, TUBGCP5, CDK1, CEP57, CSNK1E, SSNA1, ACTR1A, YWHAE, CEP152, CEP70, ALMS1, CSNK1D, PLK1, TUBG1, MAPRE1, TUBA4A, TUBGCP6, PRKACA, ODF2, HSP90AA1, CEP192, SFI1, DCTN2, CEP250, DYNLL1, OFD1, CNTRL, DYNC1H1, TUBA1A, DYNC1I2, PCM1, PCNT, TUBGCP2, AZI1, CEP164, NEDD1, CEP63, CCP110, DCTN3, CKAP5, SDCCAG8, PRKAR2B, TUBB4B, CEP78, CENPJ, NINL, PAFAH1B1, FGFR1OP, PPP2R1A, BORA, TUBGCP3, CEP290, HAUS2, AJUBA, AURKA, CLASP1, NEK2, TUBGCP4, CEP72, YWHAG, TUBG2, TUBB4A, PLK4, NDE1
CEP135ANKLE2No-1PPP2R1A
CEP135CASC5No-6PAFAH1B1, CKAP5, MAPRE1, PLK1, CLASP1, NDE1
CEP135CDK6No-2CDK1, HSP90AA1
CEP135SASS6No-1CENPJ
CDK5RAP2ANKLE2No-1PPP2R1A
CDK5RAP2CASC5No-8PAFAH1B1, CKAP5, MAPRE1, PLK1, CLASP1, UBC, CDC20, NDE1
CDK5RAP2CDK6No-6CDK1, CDK5R1, HSP90AA1, UBC, CDK5, CDC20
CDK5RAP2SASS6No-1CENPJ
PHC1CASC5No-3BUB1B, RBBP4, RBBP7
PHC1CDK6No-1CDC27
CASC5CDK6No-3UBC, CDC20, NPM1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
CEP152STILNo1PLK4

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Cell CycleR-HSA-16401703.899CEP152, CDK5RAP2, ANKLE2, CENPE, CASC5, CDK6, CENPJ, MCPH1, CEP135
Cell Cycle, MitoticR-HSA-692784.169CEP152, CDK5RAP2, ANKLE2, CENPE, CASC5, CDK6, CENPJ, MCPH1, CEP135
Recruitment of mitotic centrosome proteins and complexesR-HSA-3802706.684CENPJ, CEP152, CEP135, CDK5RAP2
Regulation of PLK1 Activity at G2/M TransitionR-HSA-25659426.664CENPJ, CEP152, CEP135, CDK5RAP2
Loss of proteins required for interphase microtubule organization from the centrosomeR-HSA-3802847.034CENPJ, CEP152, CEP135, CDK5RAP2
Organelle biogenesis and maintenanceR-HSA-18522414.634CENPJ, CEP152, CEP135, CDK5RAP2
Mitotic G2-G2/M phasesR-HSA-4532746.044CENPJ, CEP152, CEP135, CDK5RAP2
M PhaseR-HSA-688864.874MCPH1, CASC5, ANKLE2, CENPE
Anchoring of the basal body to the plasma membraneR-HSA-56209126.514CENPJ, CEP152, CEP135, CDK5RAP2
Loss of Nlp from mitotic centrosomesR-HSA-3802597.034CENPJ, CEP152, CEP135, CDK5RAP2
Assembly of the primary ciliumR-HSA-56178335.444CENPJ, CEP152, CEP135, CDK5RAP2
Centrosome maturationR-HSA-3802876.684CENPJ, CEP152, CEP135, CDK5RAP2
G2/M TransitionR-HSA-692756.064CENPJ, CEP152, CEP135, CDK5RAP2
Mitotic AnaphaseR-HSA-688825.463CASC5, ANKLE2, CENPE
Mitotic Metaphase and AnaphaseR-HSA-25553965.453CASC5, ANKLE2, CENPE
RHO GTPase EffectorsR-HSA-1952584.942CASC5, CENPE
RHO GTPases Activate ForminsR-HSA-56632206.012CASC5, CENPE
Resolution of Sister Chromatid CohesionR-HSA-25002576.182CASC5, CENPE
Oxidative Stress Induced SenescenceR-HSA-25595806.512CDK6, PHC1
Cellular SenescenceR-HSA-25595835.72CDK6, PHC1
Cellular responses to stressR-HSA-22627524.562CDK6, PHC1
Signaling by Rho GTPasesR-HSA-1943154.432CASC5, CENPE
Separation of Sister ChromatidsR-HSA-24678135.552CASC5, CENPE
Mitotic PrometaphaseR-HSA-688776.082CASC5, CENPE
Signal TransductionR-HSA-1625821.782CASC5, CENPE

NET-GE enrichment

Term New enriched termICP valueGenes
Recruitment of mitotic centrosome proteins and complexes (R-HSA-380270) -6.680.0CENPJ, CEP152, CEP135, CDK5RAP2
Regulation of PLK1 Activity at G2/M Transition (R-HSA-2565942) -6.660.0CENPJ, CEP152, CEP135, CDK5RAP2
Loss of proteins required for interphase microtubule organization from the centrosome (R-HSA-380284) -7.030.0CENPJ, CEP152, CEP135, CDK5RAP2
Centrosome maturation (R-HSA-380287) -6.680.0CENPJ, CEP152, CEP135, CDK5RAP2
Mitotic G2-G2/M phases (R-HSA-453274) -6.040.002CENPJ, CEP152, CEP135, CDK5RAP2
Cellular responses to stress (R-HSA-2262752) -4.560.046PHC1, MCPH1, CDK6, CENPE, ASPM
M Phase (R-HSA-68886) -4.870.047MCPH1, CASC5, ANKLE2, CENPE
Anchoring of the basal body to the plasma membrane (R-HSA-5620912) -6.510.0CENPJ, CEP152, CEP135, CDK5RAP2
Cell Cycle, Mitotic (R-HSA-69278) -4.160.0CEP152, CDK5RAP2, ANKLE2, CENPE, CASC5, CDK6, CENPJ, MCPH1, CEP135
Loss of Nlp from mitotic centrosomes (R-HSA-380259) -7.030.0CENPJ, CEP152, CEP135, CDK5RAP2
Cell Cycle (R-HSA-1640170) -3.890.0CEP152, CDK5RAP2, ANKLE2, CDK6, CENPE, CASC5, CENPJ, MCPH1, CEP135
Assembly of the primary cilium (R-HSA-5617833) -5.440.031CENPJ, CEP152, CEP135, CDK5RAP2
Organelle biogenesis and maintenance (R-HSA-1852241) -4.630.022CENPJ, CEP152, CEP135, CDK5RAP2
G2/M Transition (R-HSA-69275) -6.060.0CENPJ, CEP152, CEP135, CDK5RAP2
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.1815CEP152, CDK5RAP2, ANKLE2, CENPE, ASPM, CASC5, CDK6, CENPJ, MCPH1, WDR62, ZNF335, STIL, SASS6, PHC1, CEP135
protein binding (GO:0005515) 0.4614CEP152, CDK5RAP2, ANKLE2, CENPE, ASPM, CASC5, CDK6, CENPJ, MCPH1, WDR62, ZNF335, STIL, SASS6, CEP135
organic cyclic compound binding (GO:0097159) 1.055PHC1, CDK6, CENPE, CDK5RAP2, ZNF335
heterocyclic compound binding (GO:1901363) 1.065PHC1, CDK6, CENPE, CDK5RAP2, ZNF335
enzyme binding (GO:0019899) 2.274CENPJ, CEP152, ANKLE2, CDK5RAP2
tubulin binding (GO:0015631) 4.13CENPJ, CENPE, CDK5RAP2
cytoskeletal protein binding (GO:0008092) 3.023CENPJ, CENPE, CDK5RAP2
protein kinase binding (GO:0019901) 3.443CENPJ, CEP152, CDK5RAP2
kinase binding (GO:0019900) 3.323CENPJ, CEP152, CDK5RAP2
nucleic acid binding (GO:0003676) 1.443PHC1, ZNF335, CDK5RAP2
DNA binding (GO:0003677) 1.923PHC1, ZNF335, CDK5RAP2
purine ribonucleoside triphosphate binding (GO:0035639) 2.222CDK6, CENPE
macromolecular complex binding (GO:0044877) 2.612CENPE, CDK5RAP2
nucleotide binding (GO:0000166) 1.962CDK6, CENPE
purine nucleoside binding (GO:0001883) 2.222CDK6, CENPE
nucleoside binding (GO:0001882) 2.212CDK6, CENPE
cation binding (GO:0043169) 1.42PHC1, ZNF335
ion binding (GO:0043167) 1.362PHC1, ZNF335
nucleoside phosphate binding (GO:1901265) 1.962CDK6, CENPE
ribonucleoside binding (GO:0032549) 2.222CDK6, CENPE
protein complex binding (GO:0032403) 3.092CENPE, CDK5RAP2
purine nucleotide binding (GO:0017076) 2.192CDK6, CENPE
metal ion binding (GO:0046872) 1.412PHC1, ZNF335
ATP binding (GO:0005524) 2.432CDK6, CENPE
microtubule binding (GO:0008017) 4.422CENPE, CDK5RAP2
regulatory region nucleic acid binding (GO:0001067) 3.032ZNF335, CDK5RAP2
small molecule binding (GO:0036094) 1.892CDK6, CENPE
catalytic activity (GO:0003824) 1.052CDK6, CENPE
transcription regulatory region DNA binding (GO:0044212) 3.032ZNF335, CDK5RAP2
adenyl nucleotide binding (GO:0030554) 2.42CDK6, CENPE
carbohydrate derivative binding (GO:0097367) 2.032CDK6, CENPE
adenyl ribonucleotide binding (GO:0032559) 2.412CDK6, CENPE
calmodulin binding (GO:0005516) 4.552ASPM, CDK5RAP2
regulatory region DNA binding (GO:0000975) 3.032ZNF335, CDK5RAP2
purine ribonucleotide binding (GO:0032555) 2.22CDK6, CENPE
purine ribonucleoside binding (GO:0032550) 2.222CDK6, CENPE
ribonucleotide binding (GO:0032553) 2.192CDK6, CENPE
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.2616WDR62, CDK5RAP2, ANKLE2, CENPE, ASPM, CASC5, CDK6, MFSD2A, CENPJ, MCPH1, CEP135, STIL, CEP152, SASS6, PHC1, ZNF335
single-organism process (GO:0044699) 0.4816CEP152, CDK5RAP2, ANKLE2, ASPM, ZNF335, CASC5, CDK6, MFSD2A, CENPJ, MCPH1, WDR62, CENPE, STIL, SASS6, PHC1, CEP135
single-organism cellular process (GO:0044763) 0.6514CEP152, CDK5RAP2, ANKLE2, CENPE, ASPM, CASC5, CDK6, MFSD2A, CENPJ, MCPH1, WDR62, CEP135, SASS6, ZNF335
cellular component organization (GO:0016043) 1.2414CEP152, CDK5RAP2, ANKLE2, CENPE, ASPM, CASC5, CENPJ, MCPH1, WDR62, CEP135, STIL, SASS6, PHC1, ZNF335
cellular component organization or biogenesis (GO:0071840) 1.2214CEP152, CDK5RAP2, ANKLE2, CENPE, ASPM, CASC5, CENPJ, MCPH1, WDR62, ZNF335, STIL, SASS6, PHC1, CEP135
cell cycle process (GO:0022402) 2.7513CEP152, CDK5RAP2, ANKLE2, CDK6, ASPM, CASC5, CENPJ, MCPH1, WDR62, CENPE, STIL, SASS6, CEP135
organelle organization (GO:0006996) 2.0212CEP152, CDK5RAP2, ANKLE2, CENPE, ASPM, CASC5, CENPJ, MCPH1, WDR62, STIL, SASS6, CEP135
mitotic cell cycle process (GO:1903047) 3.1212CEP152, CDK5RAP2, ANKLE2, CENPE, ASPM, CASC5, CDK6, CENPJ, MCPH1, WDR62, STIL, CEP135
single-organism developmental process (GO:0044767) 1.4911WDR62, CDK5RAP2, CDK6, ASPM, CASC5, MFSD2A, MCPH1, CENPE, STIL, PHC1, ZNF335
developmental process (GO:0032502) 1.3611WDR62, CDK5RAP2, CENPE, ASPM, CASC5, CDK6, MFSD2A, MCPH1, PHC1, STIL, ZNF335
biological regulation (GO:0065007) 0.3911CDK5RAP2, ANKLE2, CENPE, ASPM, CASC5, CDK6, CENPJ, MCPH1, ZNF335, STIL, CEP135
regulation of biological process (GO:0050789) 0.4511CDK5RAP2, ANKLE2, CENPE, ASPM, CASC5, CDK6, CENPJ, MCPH1, CEP135, STIL, ZNF335
regulation of cellular process (GO:0050794) 0.511CDK5RAP2, ANKLE2, CENPE, ASPM, CASC5, CDK6, CENPJ, MCPH1, CEP135, STIL, ZNF335
anatomical structure development (GO:0048856) 1.5810CDK5RAP2, ASPM, CENPE, CDK6, MFSD2A, MCPH1, WDR62, STIL, PHC1, ZNF335
single-organism organelle organization (GO:1902589) 2.689CEP152, ASPM, CDK5RAP2, CASC5, CENPJ, MCPH1, WDR62, SASS6, CEP135
cellular component assembly (GO:0022607) 2.149CEP152, CDK5RAP2, ASPM, CENPE, CASC5, CENPJ, WDR62, SASS6, CEP135
organelle assembly (GO:0070925) 3.759CEP152, CDK5RAP2, ASPM, CENPE, CASC5, CENPJ, WDR62, SASS6, CEP135
microtubule-based process (GO:0007017) 3.549CEP152, CDK5RAP2, ASPM, CENPE, CENPJ, MCPH1, WDR62, SASS6, CEP135
positive regulation of biological process (GO:0048518) 1.28ASPM, CENPE, ANKLE2, CDK6, CENPJ, CDK5RAP2, ZNF335, CEP135
negative regulation of biological process (GO:0048519) 1.338CDK5RAP2, ANKLE2, ASPM, CASC5, CDK6, CENPJ, MCPH1, STIL
negative regulation of cellular process (GO:0048523) 1.418CDK5RAP2, ANKLE2, ASPM, CASC5, CDK6, CENPJ, MCPH1, STIL
positive regulation of cellular process (GO:0048522) 1.38ASPM, CENPE, ANKLE2, CDK6, CENPJ, CDK5RAP2, ZNF335, CEP135
centrosome organization (GO:0051297) 5.387CEP152, CDK5RAP2, CENPJ, CEP135, STIL, SASS6, WDR62
microtubule organizing center organization (GO:0031023) 5.267CEP152, CDK5RAP2, CENPJ, CEP135, STIL, SASS6, WDR62
localization (GO:0051179) 1.47CDK5RAP2, ASPM, CENPE, CASC5, MFSD2A, MCPH1, STIL
regulation of metabolic process (GO:0019222) 1.027CDK5RAP2, ANKLE2, CENPE, CASC5, CDK6, MCPH1, ZNF335
multicellular organismal process (GO:0032501) 1.456ASPM, CENPE, MCPH1, ZNF335, STIL, PHC1
single-multicellular organism process (GO:0044707) 1.786ASPM, CENPE, MCPH1, ZNF335, STIL, PHC1
regulation of organelle organization (GO:0033043) 2.726CENPE, CDK5RAP2, CENPJ, MCPH1, ZNF335, CEP135
regulation of macromolecule metabolic process (GO:0060255) 1.086ANKLE2, CDK6, CDK5RAP2, MCPH1, CENPE, ZNF335
cellular developmental process (GO:0048869) 1.826ASPM, CDK6, CDK5RAP2, MFSD2A, ZNF335, WDR62
regulation of cell cycle (GO:0051726) 2.936ASPM, CDK6, CDK5RAP2, CENPJ, MCPH1, CENPE
regulation of cellular metabolic process (GO:0031323) 1.076ANKLE2, CDK5RAP2, CASC5, MCPH1, CENPE, ZNF335
centriole replication (GO:0007099) 6.966CEP152, CDK5RAP2, CENPJ, CEP135, SASS6, WDR62
regulation of cellular component organization (GO:0051128) 2.016CENPE, CDK5RAP2, CENPJ, MCPH1, ZNF335, CEP135
animal organ development (GO:0048513) 2.536ASPM, CDK5RAP2, CDK6, MCPH1, STIL, ZNF335
cell division (GO:0051301) 3.686ASPM, ANKLE2, CDK6, CENPE, CASC5, CENPJ
centriole assembly (GO:0098534) 6.786CEP152, CDK5RAP2, CENPJ, CEP135, SASS6, WDR62
cell cycle (GO:0007049) 3.146ASPM, ANKLE2, CDK6, CENPE, CASC5, SASS6
cellular localization (GO:0051641) 2.326ASPM, CDK5RAP2, CENPE, CASC5, MCPH1, STIL
regulation of developmental process (GO:0050793) 2.15CDK6, CEP135, ASPM, CDK5RAP2, ZNF335
macromolecular complex subunit organization (GO:0043933) 2.145CENPJ, PHC1, CASC5, ZNF335, CENPE
cell cycle phase transition (GO:0044770) 4.245CENPJ, CEP152, CEP135, CDK6, CDK5RAP2
mitotic cell cycle phase transition (GO:0044772) 4.275CENPJ, CEP152, CEP135, CDK6, CDK5RAP2
single-organism localization (GO:1902578) 2.095CENPE, MCPH1, MFSD2A, ASPM, CDK5RAP2
regulation of phosphate metabolic process (GO:0019220) 2.354MCPH1, CASC5, ANKLE2, CENPE
positive regulation of metabolic process (GO:0009893) 1.744CDK6, ANKLE2, CENPE, CDK5RAP2
cell cycle G2/M phase transition (GO:0044839) 4.824CENPJ, CEP152, CEP135, CDK5RAP2
G2/M transition of mitotic cell cycle (GO:0000086) 4.844CENPJ, CEP152, CEP135, CDK5RAP2
nuclear division (GO:0000280) 3.854CASC5, ANKLE2, CENPE, ASPM
cell differentiation (GO:0030154) 2.144CDK6, WDR62, CDK5RAP2, ZNF335
microtubule cytoskeleton organization (GO:0000226) 4.134CENPJ, MCPH1, ASPM, CDK5RAP2
cell cycle phase (GO:0022403) 4.394MCPH1, CDK6, CASC5, CENPE
mitotic nuclear division (GO:0007067) 4.054CASC5, ANKLE2, CENPE, ASPM
multicellular organism development (GO:0007275) 2.544CENPE, PHC1, ZNF335, STIL
regulation of primary metabolic process (GO:0080090) 1.084CENPE, ANKLE2, CDK5RAP2, ZNF335
negative regulation of cell cycle (GO:0045786) 3.674CENPJ, MCPH1, CDK6, CDK5RAP2
positive regulation of macromolecule metabolic process (GO:0010604) 1.814CDK6, ANKLE2, CENPE, CDK5RAP2
regulation of cell cycle process (GO:0010564) 3.54CENPJ, MCPH1, CENPE, CDK5RAP2
regulation of molecular function (GO:0065009) 1.784MCPH1, CASC5, ANKLE2, CENPE
regulation of gene expression (GO:0010468) 1.374MCPH1, CDK6, ZNF335, CDK5RAP2
regulation of catalytic activity (GO:0050790) 1.974MCPH1, CASC5, ANKLE2, CENPE
regulation of phosphorus metabolic process (GO:0051174) 2.354MCPH1, CASC5, ANKLE2, CENPE
biological phase (GO:0044848) 4.374MCPH1, CDK6, CASC5, CENPE
regulation of multicellular organismal process (GO:0051239) 1.874CDK6, ASPM, CDK5RAP2, ZNF335
establishment of localization (GO:0051234) 1.484MCPH1, MFSD2A, CENPE, CDK5RAP2
organelle localization (GO:0051640) 3.944CENPE, MCPH1, ASPM, CDK5RAP2
cytoskeleton organization (GO:0007010) 3.224CENPJ, MCPH1, ASPM, CDK5RAP2
regulation of cell differentiation (GO:0045595) 2.424CDK6, ASPM, CDK5RAP2, ZNF335
regulation of multicellular organismal development (GO:2000026) 2.314CDK6, ASPM, CDK5RAP2, ZNF335
organelle fission (GO:0048285) 3.794CASC5, ANKLE2, CENPE, ASPM
single-organism cellular localization (GO:1902580) 3.164CENPE, MCPH1, ASPM, CDK5RAP2
regulation of chromosome organization (GO:0033044) 4.113MCPH1, ZNF335, CENPE
regulation of cell proliferation (GO:0042127) 2.413CDK6, ZNF335, ASPM
protein localization (GO:0008104) 2.363MCPH1, CASC5, STIL
regulation of cytoskeleton organization (GO:0051493) 3.723CENPJ, MCPH1, CDK5RAP2
positive regulation of cellular metabolic process (GO:0031325) 1.813ANKLE2, CENPE, CDK5RAP2
regulation of response to stimulus (GO:0048583) 1.543MCPH1, CDK6, ASPM
signal transduction (GO:0007165) 1.283CENPJ, CDK6, STIL
cellular macromolecular complex assembly (GO:0034622) 3.183CENPJ, CASC5, CENPE
regulation of microtubule-based process (GO:0032886) 4.793CENPJ, MCPH1, CDK5RAP2
establishment of organelle localization (GO:0051656) 4.153MCPH1, CENPE, CDK5RAP2
cerebral cortex development (GO:0021987) 5.573MCPH1, ASPM, WDR62
spindle localization (GO:0051653) 6.073MCPH1, ASPM, CDK5RAP2
cellular protein metabolic process (GO:0044267) 1.633CDK6, PHC1, ZNF335
cellular macromolecule metabolic process (GO:0044260) 0.933CDK6, PHC1, ZNF335
cellular macromolecule localization (GO:0070727) 3.13MCPH1, CASC5, STIL
chromatin organization (GO:0006325) 3.283CASC5, PHC1, ZNF335
negative regulation of multicellular organismal process (GO:0051241) 2.843CDK6, ASPM, CDK5RAP2
regulation of protein metabolic process (GO:0051246) 1.933ANKLE2, CENPE, ZNF335
regulation of cell development (GO:0060284) 3.013ASPM, CDK5RAP2, ZNF335
macromolecular complex assembly (GO:0065003) 2.553CENPJ, CASC5, CENPE
organic substance metabolic process (GO:0071704) 0.633CDK6, PHC1, ZNF335
regulation of organelle assembly (GO:1902115) 4.73CENPJ, CEP135, CDK5RAP2
regulation of protein modification process (GO:0031399) 2.323ANKLE2, CENPE, ZNF335
macromolecule localization (GO:0033036) 2.343MCPH1, CASC5, STIL
positive regulation of cell proliferation (GO:0008284) 3.013CDK6, ZNF335, ASPM
negative regulation of developmental process (GO:0051093) 3.173CDK6, ASPM, CDK5RAP2
cellular protein localization (GO:0034613) 3.113MCPH1, CASC5, STIL
centrosome duplication (GO:0051298) 6.783CEP152, SASS6, STIL
regulation of neurogenesis (GO:0050767) 3.213ASPM, CDK5RAP2, ZNF335
cell development (GO:0048468) 3.283CDK6, MFSD2A, ASPM
protein complex assembly (GO:0006461) 2.783CENPJ, CASC5, CENPE
cellular protein modification process (GO:0006464) 1.793CDK6, PHC1, ZNF335
negative regulation of cell differentiation (GO:0045596) 3.333CDK6, ASPM, CDK5RAP2
macromolecule modification (GO:0043412) 1.733CDK6, PHC1, ZNF335
protein modification process (GO:0036211) 1.793CDK6, PHC1, ZNF335
metabolic process (GO:0008152) 0.583CDK6, PHC1, ZNF335
establishment of localization in cell (GO:0051649) 2.473MCPH1, CENPE, CDK5RAP2
chromosome segregation (GO:0007059) 5.063CASC5, CENPE, CDK5RAP2
neurogenesis (GO:0022008) 5.453CDK6, CDK5RAP2, WDR62
regulation of phosphorylation (GO:0042325) 2.53MCPH1, ANKLE2, CENPE
primary metabolic process (GO:0044238) 0.693CDK6, PHC1, ZNF335
regulation of cellular protein metabolic process (GO:0032268) 1.993ANKLE2, ZNF335, CENPE
brain development (GO:0007420) 4.243ASPM, CDK5RAP2, ZNF335
positive regulation of developmental process (GO:0051094) 2.773CEP135, ZNF335, ASPM
protein metabolic process (GO:0019538) 1.453CDK6, PHC1, ZNF335
cellular metabolic process (GO:0044237) 0.693CDK6, PHC1, ZNF335
macromolecule metabolic process (GO:0043170) 0.833CDK6, PHC1, ZNF335
regulation of cellular component biogenesis (GO:0044087) 3.083CENPJ, CEP135, CDK5RAP2
regulation of nervous system development (GO:0051960) 3.13ASPM, CDK5RAP2, ZNF335
protein complex subunit organization (GO:0071822) 2.63CENPJ, CASC5, CENPE
protein localization to organelle (GO:0033365) 3.573MCPH1, CASC5, STIL
regulation of centrosome cycle (GO:0046605) 6.023CENPJ, MCPH1, CDK5RAP2
regulation of microtubule cytoskeleton organization (GO:0070507) 4.983CENPJ, MCPH1, CDK5RAP2
developmental growth (GO:0048589) 4.052STIL, ASPM
cell surface receptor signaling pathway (GO:0007166) 2.092CDK6, STIL
protein localization to centrosome (GO:0071539) 6.842MCPH1, STIL
peptidyl-amino acid modification (GO:0018193) 2.982PHC1, ZNF335
negative regulation of neuron differentiation (GO:0045665) 4.452ASPM, CDK5RAP2
regulation of neuron differentiation (GO:0045664) 3.392ASPM, CDK5RAP2
positive regulation of cell development (GO:0010720) 3.572ZNF335, ASPM
negative regulation of cell development (GO:0010721) 4.022ASPM, CDK5RAP2
establishment of spindle orientation (GO:0051294) 6.432MCPH1, CDK5RAP2
mitotic anaphase (GO:0000090) 4.72CASC5, CENPE
establishment of spindle localization (GO:0051293) 6.172MCPH1, CDK5RAP2
developmental process involved in reproduction (GO:0003006) 3.362CASC5, ASPM
regulation of RNA biosynthetic process (GO:2001141) 1.552ZNF335, CDK5RAP2
stem cell population maintenance (GO:0019827) 4.832MCPH1, ASPM
single organism reproductive process (GO:0044702) 2.732CASC5, ASPM
vesicle-mediated transport (GO:0016192) 2.722MFSD2A, CENPE
peptidyl-lysine modification (GO:0018205) 3.982PHC1, ZNF335
immune system process (GO:0002376) 2.292CDK6, CENPE
covalent chromatin modification (GO:0016569) 3.892PHC1, ZNF335
negative regulation of metabolic process (GO:0009892) 1.932CASC5, ANKLE2
movement of cell or subcellular component (GO:0006928) 2.612CENPE, ASPM
positive regulation of gene expression (GO:0010628) 2.352CDK6, CDK5RAP2
sister chromatid cohesion (GO:0007062) 5.032CASC5, CENPE
regulation of mitotic cell cycle (GO:0007346) 3.712CENPJ, CENPE
regulation of kinase activity (GO:0043549) 3.072MCPH1, CENPE
regulation of immune system process (GO:0002682) 2.52CDK6, ZNF335
histone modification (GO:0016570) 3.912PHC1, ZNF335
positive regulation of stem cell proliferation (GO:2000648) 6.072ZNF335, ASPM
regulation of biological quality (GO:0065008) 1.682CDK6, ASPM
anatomical structure formation involved in morphogenesis (GO:0048646) 3.012CASC5, STIL
transport (GO:0006810) 1.512MFSD2A, CENPE
regulation of biosynthetic process (GO:0009889) 1.372ZNF335, CDK5RAP2
cell cycle arrest (GO:0007050) 4.692MCPH1, CDK6
regulation of cell cycle phase transition (GO:1901987) 4.152CENPJ, CENPE
mitotic spindle organization (GO:0007052) 6.292STIL, WDR62
mitotic prometaphase (GO:0000236) 5.152CASC5, CENPE
regulation of dephosphorylation (GO:0035303) 4.672CASC5, ANKLE2
neuronal stem cell population maintenance (GO:0097150) 6.732MCPH1, ASPM
establishment of mitotic spindle orientation (GO:0000132) 6.682MCPH1, CDK5RAP2
maintenance of cell number (GO:0098727) 4.822MCPH1, ASPM
regulation of response to stress (GO:0080134) 2.532MCPH1, CDK6
positive regulation of protein modification process (GO:0031401) 2.72ANKLE2, CENPE
regulation of transferase activity (GO:0051338) 2.882MCPH1, CENPE
positive regulation of nervous system development (GO:0051962) 3.642ZNF335, ASPM
negative regulation of nervous system development (GO:0051961) 4.152ASPM, CDK5RAP2
regulation of macromolecule biosynthetic process (GO:0010556) 1.432ZNF335, CDK5RAP2
positive regulation of phosphorus metabolic process (GO:0010562) 2.782ANKLE2, CENPE
regulation of phosphatase activity (GO:0010921) 4.882CASC5, ANKLE2
embryo development (GO:0009790) 4.22ZNF335, STIL
embryo development ending in birth or egg hatching (GO:0009792) 4.352ZNF335, STIL
regulation of mitotic cell cycle phase transition (GO:1901990) 4.232CENPJ, CENPE
anatomical structure morphogenesis (GO:0009653) 2.532ZNF335, STIL
in utero embryonic development (GO:0001701) 4.42ZNF335, STIL
anaphase (GO:0051322) 4.72CASC5, CENPE
positive regulation of multicellular organismal process (GO:0051240) 2.492ZNF335, ASPM
negative regulation of phosphorus metabolic process (GO:0010563) 3.452CASC5, ANKLE2
positive regulation of protein metabolic process (GO:0051247) 2.432ANKLE2, CENPE
negative regulation of neurogenesis (GO:0050768) 4.222ASPM, CDK5RAP2
positive regulation of neurogenesis (GO:0050769) 3.772ZNF335, ASPM
regulation of neural precursor cell proliferation (GO:2000177) 5.452ZNF335, ASPM
positive regulation of cellular protein metabolic process (GO:0032270) 2.492ANKLE2, CENPE
chordate embryonic development (GO:0043009) 4.382ZNF335, STIL
regulation of stem cell proliferation (GO:0072091) 5.62ZNF335, ASPM
regulation of hydrolase activity (GO:0051336) 2.532CASC5, ANKLE2
positive regulation of neuroblast proliferation (GO:0002052) 6.682ZNF335, ASPM
regulation of nucleic acid-templated transcription (GO:1903506) 1.552ZNF335, CDK5RAP2
positive regulation of cell differentiation (GO:0045597) 3.012ZNF335, ASPM
regulation of RNA metabolic process (GO:0051252) 1.522ZNF335, CDK5RAP2
protein localization to microtubule cytoskeleton (GO:0072698) 6.42MCPH1, STIL
positive regulation of neural precursor cell proliferation (GO:2000179) 6.092ZNF335, ASPM
response to stimulus (GO:0050896) 1.222CENPJ, CDK6
cell projection organization (GO:0030030) 3.142CEP152, ZNF335
regulation of cellular biosynthetic process (GO:0031326) 1.382ZNF335, CDK5RAP2
negative regulation of cellular metabolic process (GO:0031324) 2.012CASC5, ANKLE2
protein localization to cytoskeleton (GO:0044380) 6.262MCPH1, STIL
attachment of spindle microtubules to kinetochore (GO:0008608) 7.162CASC5, CENPE
regulation of centrosome duplication (GO:0010824) 6.232CENPJ, CDK5RAP2
negative regulation of cell cycle process (GO:0010948) 4.372CENPJ, CDK5RAP2
regulation of centriole replication (GO:0046599) 7.162CENPJ, CDK5RAP2
establishment of mitotic spindle localization (GO:0040001) 6.512MCPH1, CDK5RAP2
growth (GO:0040007) 3.82STIL, ASPM
regulation of transcription, DNA-templated (GO:0006355) 1.562ZNF335, CDK5RAP2
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462ZNF335, CDK5RAP2
regulation of neuroblast proliferation (GO:1902692) 6.362ZNF335, ASPM
positive regulation of phosphate metabolic process (GO:0045937) 2.782ANKLE2, CENPE
negative regulation of phosphate metabolic process (GO:0045936) 3.452CASC5, ANKLE2
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432ZNF335, CDK5RAP2
reproductive process (GO:0022414) 2.552CASC5, ASPM
regulation of nitrogen compound metabolic process (GO:0051171) 1.362ZNF335, CDK5RAP2
cellular process involved in reproduction in multicellular organism (GO:0022412) 4.32CASC5, ASPM
mitotic cell cycle phase (GO:0098763) 5.152CASC5, CENPE
cellular protein complex assembly (GO:0043623) 3.92CENPJ, CENPE
chromosome organization (GO:0051276) 3.792CASC5, CENPE

NET-GE enrichment

Term New enriched termICP valueGenes
organelle organization (GO:0006996) -2.020.0CEP152, CDK5RAP2, ANKLE2, ASPM, CENPE, CASC5, CENPJ, ZNF335, SASS6, PHC1, CEP135
microtubule organizing center organization (GO:0031023) -5.260.0CENPJ, CEP152, SASS6, CEP135, CDK5RAP2
centrosome duplication (GO:0051298) -6.780.035CENPJ, CEP152, SASS6
cell cycle G2/M phase transition (GO:0044839) -4.820.003CENPJ, CEP152, CEP135, CDK6, CDK5RAP2
G2/M transition of mitotic cell cycle (GO:0000086) -4.840.003CENPJ, CEP152, CEP135, CDK6, CDK5RAP2
centrosome organization (GO:0051297) -5.380.0CENPJ, CEP152, SASS6, CEP135, CDK5RAP2
single-organism organelle organization (GO:1902589) -2.680.0CEP152, CDK5RAP2, ANKLE2, ASPM, CASC5, CENPJ, ZNF335, SASS6, PHC1, CEP135
mitotic cell cycle process (GO:1903047) -3.120.002CEP152, CDK5RAP2, ANKLE2, ASPM, CENPE, CASC5, CDK6, CENPJ, CEP135
cell cycle phase transition (GO:0044770) -4.240.002CENPJ, CEP152, CEP135, CDK6, CDK5RAP2
mitotic cell cycle phase transition (GO:0044772) -4.270.002CENPJ, CEP152, CEP135, CDK6, CDK5RAP2
microtubule-based process (GO:0007017) -3.540.0CEP152, CDK5RAP2, CENPE, CASC5, CENPJ, SASS6, CEP135
cell cycle process (GO:0022402) -2.750.0CEP152, CDK5RAP2, ANKLE2, ASPM, CENPE, CASC5, CDK6, CENPJ, SASS6, CEP135
centriole replication (GO:0007099) -6.960.0CENPJ, CEP152, SASS6, CEP135
centriole assembly (GO:0098534) -6.780.0CENPJ, CEP152, SASS6, CEP135
neurogenesis (GO:0022008) -5.450.003CDK6, WDR62, CDK5RAP2
regulation of centriole replication (GO:0046599) -7.160.014CENPJ, CDK5RAP2
cell cycle (GO:0007049) -3.140.0CEP152, CDK5RAP2, ANKLE2, CDK6, CENPE, CASC5, CENPJ, MCPH1, CEP135
mitotic cell cycle (GO:0000278) NEW5.920.0CEP152, CDK5RAP2, ANKLE2, CENPE, CASC5, CDK6, CENPJ, MCPH1, CEP135
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.1116CEP152, CDK5RAP2, ANKLE2, CENPE, ASPM, CASC5, CDK6, MFSD2A, CENPJ, MCPH1, WDR62, CEP135, STIL, SASS6, PHC1, ZNF335
intracellular organelle part (GO:0044446) 0.8116CEP135, CEP152, CDK5RAP2, ANKLE2, CENPE, ASPM, CASC5, CDK6, MFSD2A, CENPJ, MCPH1, ZNF335, STIL, SASS6, PHC1, WDR62
intracellular organelle (GO:0043229) 0.5116CEP152, CDK5RAP2, ANKLE2, ASPM, ZNF335, CASC5, CDK6, MFSD2A, CENPJ, MCPH1, WDR62, CENPE, STIL, SASS6, PHC1, CEP135
intracellular part (GO:0044424) 0.2816CEP152, CDK5RAP2, ANKLE2, ASPM, ZNF335, CASC5, CDK6, MFSD2A, CENPJ, MCPH1, WDR62, CENPE, STIL, SASS6, PHC1, CEP135
organelle (GO:0043226) 0.416CEP152, CDK5RAP2, ANKLE2, ASPM, ZNF335, CASC5, CDK6, MFSD2A, CENPJ, MCPH1, WDR62, CENPE, STIL, SASS6, PHC1, CEP135
organelle part (GO:0044422) 0.7916WDR62, CDK5RAP2, ANKLE2, CENPE, ASPM, CASC5, CDK6, MFSD2A, CENPJ, MCPH1, CEP135, STIL, CEP152, SASS6, PHC1, ZNF335
cytoplasm (GO:0005737) 1.0113CEP152, CDK5RAP2, CENPE, ASPM, CASC5, CDK6, MFSD2A, CENPJ, MCPH1, WDR62, STIL, SASS6, CEP135
cytoplasmic part (GO:0044444) 0.8212CEP152, CDK5RAP2, ANKLE2, CENPE, CASC5, CDK6, MFSD2A, CENPJ, WDR62, STIL, SASS6, CEP135
non-membrane-bounded organelle (GO:0043228) 1.7612CEP152, CDK5RAP2, ASPM, CENPE, CASC5, CDK6, CENPJ, MCPH1, WDR62, STIL, SASS6, CEP135
intracellular non-membrane-bounded organelle (GO:0043232) 1.7612CEP152, CDK5RAP2, ASPM, CENPE, CASC5, CDK6, CENPJ, MCPH1, WDR62, STIL, SASS6, CEP135
cytoskeletal part (GO:0044430) 2.4911CEP152, CDK5RAP2, ASPM, CENPE, CDK6, CENPJ, MCPH1, WDR62, STIL, SASS6, CEP135
membrane-bounded organelle (GO:0043227) 0.4711WDR62, CDK5RAP2, ANKLE2, ASPM, CENPE, CASC5, CDK6, MFSD2A, MCPH1, PHC1, ZNF335
cytoskeleton (GO:0005856) 2.5510CEP152, CDK5RAP2, ASPM, CENPE, CDK6, CENPJ, MCPH1, WDR62, SASS6, CEP135
intracellular membrane-bounded organelle (GO:0043231) 0.610WDR62, ASPM, ANKLE2, CDK5RAP2, CENPE, CASC5, CDK6, MFSD2A, PHC1, ZNF335
microtubule organizing center (GO:0005815) 3.429CEP152, CDK6, CDK5RAP2, CENPJ, MCPH1, WDR62, STIL, SASS6, CEP135
centrosome (GO:0005813) 3.758CEP152, CDK6, CDK5RAP2, CENPJ, WDR62, STIL, SASS6, CEP135
cytosol (GO:0005829) 1.688CEP152, CDK5RAP2, CENPE, CDK6, CASC5, CENPJ, STIL, CEP135
nucleus (GO:0005634) 1.077WDR62, ASPM, CDK6, CENPE, CASC5, ZNF335, PHC1
microtubule organizing center part (GO:0044450) 4.87CEP152, CDK5RAP2, CENPJ, WDR62, STIL, SASS6, CEP135
protein complex (GO:0043234) 1.516CDK6, CENPE, CASC5, CENPJ, ZNF335, PHC1
macromolecular complex (GO:0032991) 1.356CDK6, CENPE, CASC5, CENPJ, ZNF335, PHC1
nuclear part (GO:0044428) 1.556CEP152, CDK6, CASC5, MCPH1, ZNF335, PHC1
centriole (GO:0005814) 5.156CEP152, CENPJ, CEP135, STIL, SASS6, WDR62
nucleoplasm (GO:0005654) 1.895MCPH1, CASC5, CDK6, CEP152, PHC1
microtubule (GO:0005874) 3.814CENPE, CENPJ, ASPM, CDK5RAP2
membrane (GO:0016020) 0.684MFSD2A, ANKLE2, CENPE, CDK5RAP2
supramolecular fiber (GO:0099512) 3.314CENPE, CENPJ, ASPM, CDK5RAP2
polymeric cytoskeletal fiber (GO:0099513) 3.314CENPE, CENPJ, ASPM, CDK5RAP2
extracellular vesicle (GO:1903561) 1.893MCPH1, CASC5, CDK5RAP2
extracellular organelle (GO:0043230) 1.893MCPH1, CASC5, CDK5RAP2
catalytic complex (GO:1902494) 2.93CDK6, PHC1, ZNF335
extracellular exosome (GO:0070062) 1.893MCPH1, CASC5, CDK5RAP2
integral component of membrane (GO:0016021) 1.143MFSD2A, ANKLE2, CDK5RAP2
spindle pole (GO:0000922) 5.083CDK5RAP2, ASPM, WDR62
transferase complex (GO:1990234) 3.323CDK6, PHC1, ZNF335
membrane part (GO:0044425) 0.953MFSD2A, ANKLE2, CDK5RAP2
membrane-bounded vesicle (GO:0031988) 1.713MCPH1, CASC5, CDK5RAP2
extracellular region part (GO:0044421) 1.573MCPH1, CASC5, CDK5RAP2
intrinsic component of membrane (GO:0031224) 1.133MFSD2A, ANKLE2, CDK5RAP2
vesicle (GO:0031982) 1.643MCPH1, CASC5, CDK5RAP2
pericentriolar material (GO:0000242) 6.912CEP152, CDK5RAP2
microtubule end (GO:1990752) 6.712ASPM, CDK5RAP2
endoplasmic reticulum (GO:0005783) 2.562MFSD2A, ANKLE2
midbody (GO:0030496) 4.952CENPE, ASPM
mitotic spindle pole (GO:0097431) 7.612ASPM, CDK5RAP2
endoplasmic reticulum membrane (GO:0005789) 2.952MFSD2A, ANKLE2
cell (GO:0005623) 5.222MCPH1, CENPE
endoplasmic reticulum part (GO:0044432) 2.732MFSD2A, ANKLE2
spindle (GO:0005819) 4.522CENPE, ASPM
deuterosome (GO:0098536) 8.192CEP152, SASS6
kinetochore (GO:0000776) 5.052CASC5, CENPE
chromosomal part (GO:0044427) 3.182CASC5, CENPE
chromosome (GO:0005694) 3.782CASC5, CENPE
chromosome, centromeric region (GO:0000775) 4.852CASC5, CENPE
chromosomal region (GO:0098687) 4.192CASC5, CENPE
condensed chromosome kinetochore (GO:0000777) 5.312CASC5, CENPE

NET-GE enrichment

Term New enriched termICP valueGenes
non-membrane-bounded organelle (GO:0043228) -1.760.03CEP152, CDK5RAP2, CENPE, CASC5, CENPJ, STIL, SASS6, CEP135
intracellular non-membrane-bounded organelle (GO:0043232) -1.760.03CEP152, CDK5RAP2, CENPE, CASC5, CENPJ, STIL, SASS6, CEP135
centrosome (GO:0005813) -3.750.0CEP152, CDK5RAP2, CENPE, CENPJ, STIL, SASS6, CEP135
centriole (GO:0005814) -5.150.003CENPJ, SASS6, CEP135, CDK5RAP2
microtubule organizing center (GO:0005815) -3.420.0CEP152, CDK5RAP2, CENPE, CENPJ, MCPH1, STIL, SASS6, CEP135
intracellular organelle part (GO:0044446) -0.810.003CEP152, CDK5RAP2, ANKLE2, ASPM, CASC5, MFSD2A, CENPJ, MCPH1, WDR62, CENPE, STIL, SASS6, PHC1, CEP135
cytoskeletal part (GO:0044430) -2.490.0CEP152, CDK5RAP2, ASPM, CENPE, CENPJ, MCPH1, WDR62, STIL, SASS6, CEP135
deuterosome (GO:0098536) -8.190.0CENPJ, CEP152, SASS6
spindle pole (GO:0000922) -5.080.006CDK5RAP2, ASPM, WDR62
organelle part (GO:0044422) -0.790.005CEP135, CEP152, CDK5RAP2, ANKLE2, CENPE, ASPM, CASC5, MFSD2A, CENPJ, MCPH1, WDR62, STIL, SASS6, PHC1
microtubule organizing center part (GO:0044450) -4.80.007CENPJ, SASS6, CEP135, CDK5RAP2