Disease table of CATARACT OMIM ID: PS116200

Gene-disease associations table

Gene	Associated with CATARACT in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
AGK	ClinVar, OMIM	HGNC link	7q34	2	PS116200, PS603041
HSF4	ClinVar, OMIM, HUMSAVAR	HGNC link	16q22.1	1	PS116200
UNC45B	ClinVar, OMIM, HUMSAVAR	HGNC link	17q12	1	PS116200
CHMP4B	ClinVar, OMIM, HUMSAVAR	HGNC link	20q11.22	1	PS116200
CRYGS	ClinVar, OMIM, HUMSAVAR	HGNC link	3q27.3	1	PS116200
CRYAB	ClinVar, OMIM	HGNC link	11q23.1	3	PS116200, PS115200, PS601419
EPHA2	ClinVar, OMIM, HUMSAVAR	HGNC link	1p36.13	1	PS116200
CRYAA	ClinVar, OMIM, HUMSAVAR	HGNC link	21q22.3	1	PS116200
PITX3	OMIM, HUMSAVAR	HGNC link	10q24.32	2	PS116200, 107250
MIP	ClinVar, OMIM, HUMSAVAR	HGNC link	12q13.3	1	PS116200
CRYBA2	OMIM, HUMSAVAR	HGNC link	2q35	1	PS116200
CRYGB	OMIM	HGNC link	2q33.3	1	PS116200
CRYGC	ClinVar, OMIM, HUMSAVAR	HGNC link	2q33.3	1	PS116200
CRYGD	ClinVar, OMIM, HUMSAVAR	HGNC link	2q33.3	1	PS116200
CRYBA1	ClinVar, OMIM	HGNC link	17q11.2	1	PS116200
CRYBA4	ClinVar, OMIM, HUMSAVAR	HGNC link	22q12.1	1	PS116200
GCNT2	OMIM, HUMSAVAR	HGNC link	6p24.3	2	PS116200, 110800
LIM2	ClinVar, OMIM, HUMSAVAR	HGNC link	19q13.41	1	PS116200
LSS	ClinVar, OMIM, HUMSAVAR	HGNC link	21q22.3	1	PS116200
NHS	ClinVar, OMIM	HGNC link	Xp22.2	2	PS116200, 302350
SIPA1L3	ClinVar, OMIM	HGNC link	19q13.13	1	PS116200
TDRD7	OMIM	HGNC link	9q22.33	1	PS116200
BFSP2	ClinVar, OMIM, HUMSAVAR	HGNC link	3q22.1	1	PS116200
BFSP1	OMIM	HGNC link	20p12.1	1	PS116200
CRYBB2	ClinVar, OMIM	HGNC link	22q11.23	1	PS116200
CRYBB3	ClinVar, OMIM, HUMSAVAR	HGNC link	22q11.23	1	PS116200
CRYBB1	ClinVar, OMIM, HUMSAVAR	HGNC link	22q12.1	1	PS116200
FYCO1	ClinVar, OMIM, HUMSAVAR	HGNC link	3p21.31	1	PS116200
GJA3	ClinVar, OMIM, HUMSAVAR	HGNC link	13q12.11	1	PS116200
GJA8	ClinVar, OMIM, HUMSAVAR	HGNC link	1q21.2	1	PS116200
VIM	ClinVar, OMIM, HUMSAVAR	HGNC link	10p13	1	PS116200
MAF	ClinVar, OMIM, HUMSAVAR	HGNC link	16q23.2	2	PS116200, 601088
WFS1	ClinVar, OMIM, HUMSAVAR	HGNC link	4p16.1	5	PS124900, 222300, PS116200, 614296, 125853

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Common tandem group	Number of genes in this tandem group associated to this disease	Genes in this tandem group associated to this disease
Group 146	3	CRYGD, CRYGC, CRYGB
Group 936	4	CRYBA4, CRYBB3, CRYBB2, CRYBB1

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
2q33.3	3	CRYGD, CRYGC, CRYGB
21q22.3	2	CRYAA, LSS
22q11.23	2	CRYBB3, CRYBB2
22q12.1	2	CRYBA4, CRYBB1

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
22q12	2	CRYBA4, CRYBB1
22q11	2	CRYBB3, CRYBB2
21q22	2	CRYAA, LSS
19q13	2	LIM2, SIPA1L3
2q33	3	CRYGD, CRYGC, CRYGB

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
19q1	2	LIM2, SIPA1L3
22q1	4	CRYBA4, CRYBB3, CRYBB2, CRYBB1
2q3	4	CRYGB, CRYGC, CRYBA2, CRYGD
3q2	2	CRYGS, BFSP2
17q1	2	UNC45B, CRYBA1
16q2	2	HSF4, MAF
21q2	2	CRYAA, LSS

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
16q	2	HSF4, MAF
22q	4	CRYBA4, CRYBB3, CRYBB2, CRYBB1
3q	2	CRYGS, BFSP2
21q	2	CRYAA, LSS
19q	2	LIM2, SIPA1L3
17q	2	UNC45B, CRYBA1
2q	4	CRYGB, CRYGC, CRYBA2, CRYGD

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
10	2	VIM, PITX3
20	2	BFSP1, CHMP4B
21	2	CRYAA, LSS
17	2	UNC45B, CRYBA1
16	2	HSF4, MAF
19	2	LIM2, SIPA1L3
22	4	CRYBA4, CRYBB3, CRYBB2, CRYBB1
1	2	GJA8, EPHA2
3	3	CRYGS, BFSP2, FYCO1
2	4	CRYGB, CRYGC, CRYBA2, CRYGD

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
HSF4	YES	2	HIF1A, DNASE2B	0
PITX3	YES	2	MIP, TH	1	MIP
MAF	YES	7	CCND2, IL4, IL5, GCLC, MMP13, ITGB7, MAFF	0
TP53	NO	159	ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING1	2	EPHA2, CRYAB

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
CRYAB	YES	4	TP53, HMGA1, TFAP2B, TFAP2A	0
EPHA2	YES	3	HIC1, MTA1, TP53	0
MIP	YES	1	PITX3	1	PITX3
LSS	YES	2	HDAC3, YY1	0
VIM	YES	16	SP1, ETV4, CTNNB1, TCF4, ZEB2, HDGF, AR, TRIM16, ZNF148, PARP1, SOX2, HOXA7, ERG, KLF8, HIPK2, HIF1A	0
MAF	YES	1	MAFF	0
WFS1	YES	1	XBP1	0

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
AGK	EPHA2	No	1	NTRK1
AGK	GCNT2	No	1	PARK2
AGK	LSS	No	1	NTRK1
AGK	VIM	No	7	DCTN1, PARK2, RNF2, NTRK1, FBXO6, RYK, CUL3
HSF4	CHMP4B	No	1	TARBP1
HSF4	VIM	No	1	NUDT21
UNC45B	EPHA2	No	1	HSP90AA1
UNC45B	VIM	No	1	AHSA1
CHMP4B	CRYAB	No	2	CC2D1A, TP53
CHMP4B	EPHA2	No	1	CLTC
CHMP4B	SIPA1L3	No	3	CAPZA2, ACTB, MYO19
CHMP4B	VIM	No	6	FLOT1, VCP, HCVGP1, VCAM1, TP53, ITGA4
CHMP4B	MAF	No	1	UBE2I
CHMP4B	WFS1	No	1	EIF6
CRYGS	CRYBB1	No	1	TERF2IP
CRYAB	EPHA2	No	1	APP
CRYAB	CRYAA	Yes	11	BCL2L1, BAX, CRYGD, HSPB2, MIP, CRYGC, CRYAA, CRYAB, CRYBA1, HSPB1, CRYBB2
CRYAB	MIP	Yes	4	CRYAA, CRYBB2, CRYGC, CRYAB
CRYAB	CRYGB	No	1	CRYGC
CRYAB	CRYGC	Yes	8	CRYAB, CRYGD, HSPB2, MIP, CRYGC, CRYAA, HSPB1, CRYBB2
CRYAB	CRYGD	Yes	4	CRYAA, CRYAB, CRYGC, CRYGD
CRYAB	CRYBA1	Yes	4	CRYBA1, CRYAA, CRYAB, CRYBB1
CRYAB	CRYBB2	Yes	6	CRYAB, MIP, CRYGC, CRYAA, HSPB1, CRYBB2
CRYAB	CRYBB3	No	1	CRYBA1
CRYAB	CRYBB1	Yes	2	CRYBA1, CRYAB
CRYAB	FYCO1	No	2	GOPC, APP
CRYAB	VIM	No	12	CASP7, GOPC, CASP8, NEFL, TP53, CASP3, HSPB1, APP, GFAP, VPS33A, HDAC1, BAG3
EPHA2	LSS	No	1	NTRK1
EPHA2	SIPA1L3	No	1	ELAVL1
EPHA2	TDRD7	No	1	CDK17
EPHA2	FYCO1	No	1	APP
EPHA2	VIM	No	4	NTRK1, GRB2, CBL, APP
CRYAA	MIP	Yes	4	CRYAA, CRYBB2, CRYGC, CRYAB
CRYAA	CRYGB	No	1	CRYGC
CRYAA	CRYGC	Yes	8	CRYAB, CRYGD, HSPB2, MIP, CRYGC, CRYAA, HSPB1, CRYBB2
CRYAA	CRYGD	Yes	4	CRYAA, CRYAB, CRYGC, CRYGD
CRYAA	CRYBA1	Yes	3	CRYBA1, CRYAA, CRYAB
CRYAA	CRYBB2	Yes	6	CRYAB, MIP, CRYGC, CRYAA, HSPB1, CRYBB2
CRYAA	CRYBB3	No	1	CRYBA1
CRYAA	CRYBB1	No	2	CRYBA1, CRYAB
CRYAA	VIM	No	1	HSPB1
PITX3	VIM	No	1	MTA1
MIP	CRYGB	No	1	CRYGC
MIP	CRYGC	Yes	4	CRYAA, CRYBB2, CRYGC, CRYAB
MIP	CRYGD	No	3	CRYAA, CRYAB, CRYGC
MIP	CRYBA1	No	2	CRYAB, CRYAA
MIP	CRYBB2	Yes	4	CRYAA, CRYBB2, CRYGC, CRYAB
MIP	CRYBB1	No	1	CRYAB
CRYGB	CRYGC	Yes	1	CRYGC
CRYGB	CRYGD	No	1	CRYGC
CRYGB	CRYBB2	No	1	CRYGC
CRYGC	CRYGD	Yes	4	CRYAA, CRYAB, CRYGC, CRYGD
CRYGC	CRYBA1	No	2	CRYAB, CRYAA
CRYGC	CRYBB2	Yes	6	CRYAB, MIP, CRYGC, CRYAA, HSPB1, CRYBB2
CRYGC	CRYBB1	No	1	CRYAB
CRYGC	VIM	No	1	HSPB1
CRYGD	CRYBA1	No	2	CRYAB, CRYAA
CRYGD	CRYBB2	No	3	CRYAA, CRYAB, CRYGC
CRYGD	CRYBB1	No	1	CRYAB
CRYBA1	CRYBB2	No	2	CRYAB, CRYAA
CRYBA1	CRYBB3	Yes	1	CRYBA1
CRYBA1	CRYBB1	Yes	2	CRYBA1, CRYAB
GCNT2	VIM	No	2	PARK2, TRIM68
LSS	SIPA1L3	No	1	MYH9
LSS	FYCO1	No	1	XPO1
LSS	VIM	No	2	NTRK1, XPO1
NHS	FYCO1	No	1	KIF5B
SIPA1L3	VIM	No	1	YWHAQ
BFSP2	MAF	No	1	ATF4
BFSP1	VIM	Yes	1	VIM
CRYBB2	CRYBB1	No	1	CRYAB
CRYBB2	VIM	No	1	HSPB1
CRYBB3	CRYBB1	No	1	CRYBA1
CRYBB1	WFS1	No	1	TERF1
FYCO1	VIM	No	7	GOPC, RPA1, PPL, FOXK1, APP, XPO1, CCT6A
GJA3	GJA8	No	1	TJP1
GJA3	VIM	No	2	TJP1, MCM2
GJA8	VIM	No	1	TJP1
VIM	MAF	No	1	MAFG
VIM	WFS1	No	1	SMURF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
HSF4	UNC45B	No	-	1	HSP90AA1
HSF4	EPHA2	No	-	1	HSP90AA1
HSF4	CRYBA4	No	-	4	HSPA6, HSPA8, HSP90AA1, HSP90AB1
UNC45B	CHMP4B	No	-	2	UBC, UBB
UNC45B	EPHA2	No	-	2	UBC, HSP90AA1
UNC45B	CRYBA4	No	-	2	UBB, HSP90AA1
UNC45B	LSS	No	-	1	UBC
UNC45B	VIM	No	-	1	UBC
UNC45B	WFS1	No	-	1	UBC
CHMP4B	EPHA2	No	-	1	UBC
CHMP4B	CRYBA4	No	-	1	UBB
CHMP4B	LSS	No	-	1	UBC
CHMP4B	VIM	No	-	1	UBC
CHMP4B	MAF	No	-	1	UBE2I
CHMP4B	WFS1	No	-	1	UBC
EPHA2	CRYBA4	No	-	1	HSP90AA1
EPHA2	LSS	No	-	1	UBC
EPHA2	VIM	No	-	2	UBC, FGF2
EPHA2	MAF	No	-	1	TP53
EPHA2	WFS1	No	-	1	UBC
CRYAA	MIP	Yes	binding	2	CRYBB2, CRYGC
CRYAA	CRYGC	Yes	binding	2	MIP, CRYBB2
CRYAA	CRYGD	Yes	binding	0
CRYAA	CRYBA1	Yes	binding	0
CRYAA	CRYBA4	No	-	0
CRYAA	CRYBB2	Yes	binding	2	MIP, CRYGC
CRYAA	CRYBB3	No	-	1	CRYBA1
CRYAA	CRYBB1	No	-	1	CRYBA1
PITX3	MAF	No	-	1	MYB
MIP	CRYGC	Yes	binding	2	CRYBB2, CRYAA
MIP	CRYGD	No	-	1	CRYAA
MIP	CRYBA1	No	-	1	CRYAA
MIP	CRYBB2	Yes	binding	2	CRYAA, CRYGC
CRYGC	CRYGD	No	-	1	CRYAA
CRYGC	CRYBA1	No	-	1	CRYAA
CRYGC	CRYBA4	No	-	0
CRYGC	CRYBB2	Yes	binding	2	MIP, CRYAA
CRYGD	CRYBA1	No	-	1	CRYAA
CRYGD	CRYBB2	No	-	1	CRYAA
CRYBA1	CRYBB2	No	-	1	CRYAA
CRYBA1	CRYBB3	Yes	binding	0
CRYBA1	CRYBB1	Yes	binding	0
CRYBA4	CRYBB2	No	-	0
CRYBA4	MAF	No	-	2	CREBBP, EP300
GCNT2	LSS	No	-	1	YY1
LSS	VIM	No	-	1	UBC
LSS	WFS1	No	-	1	UBC
BFSP2	BFSP1	Yes	binding	0
BFSP2	VIM	No	-	1	BFSP1
BFSP1	VIM	Yes	binding	0
CRYBB3	CRYBB1	No	-	1	CRYBA1
VIM	WFS1	No	-	1	UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

KEGG pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Protein processing in endoplasmic reticulum	hsa04141	5.35	3	WFS1, CRYAA, CRYAB
Metabolic pathways	hsa01100	2.49	3	LSS, GCNT2, AGK
Rap1 signaling pathway	hsa04015	4.97	2	EPHA2, SIPA1L3

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Membrane Trafficking	R-HSA-199991	5.26	3	CHMP4B, GJA3, GJA8
Vesicle-mediated transport	R-HSA-5653656	4.33	3	CHMP4B, GJA3, GJA8
Gap junction trafficking	R-HSA-190828	7.59	2	GJA3, GJA8
Gap junction trafficking and regulation	R-HSA-157858	7.52	2	GJA3, GJA8
Gap junction assembly	R-HSA-190861	8.03	2	GJA3, GJA8

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Membrane Trafficking (R-HSA-199991)	-	5.26	0.035	VIM, CHMP4B, CRYAB, GJA3, GJA8
Gap junction trafficking (R-HSA-190828)	-	7.59	0.028	GJA3, GJA8
Gap junction trafficking and regulation (R-HSA-157858)	-	7.52	0.031	GJA3, GJA8
Gap junction assembly (R-HSA-190861)	-	8.03	0.015	GJA3, GJA8

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	25	GJA3, UNC45B, CRYAA, WFS1, CRYBA4, CRYBA1, VIM, CRYBB3, HSF4, CRYGC, EPHA2, AGK, TDRD7, CRYAB, MIP, CRYBB1, BFSP2, PITX3, BFSP1, CHMP4B, CRYGD, MAF, CRYBA2, CRYBB2, FYCO1
protein binding (GO:0005515)	0.46	23	GJA3, CRYAA, WFS1, UNC45B, CRYBA1, VIM, CRYBB3, HSF4, CRYGC, EPHA2, TDRD7, CRYAB, MIP, CRYBA4, BFSP2, CRYBB1, BFSP1, CHMP4B, CRYGD, FYCO1, CRYBA2, CRYBB2, MAF
structural constituent of eye lens (GO:0005212)	6.74	17	CRYAB, CRYGB, CRYGD, MIP, CRYAA, CRYBA2, CRYGS, CRYBB1, CRYBA1, CRYGC, VIM, CRYBB3, BFSP2, CRYBA4, CRYBB2, BFSP1, LIM2
structural molecule activity (GO:0005198)	3.1	17	CRYAB, CRYGB, CRYGD, MIP, CRYAA, CRYBA2, CRYGS, CRYBB1, CRYBA1, CRYGC, VIM, CRYBB3, BFSP2, CRYBA4, CRYBB2, BFSP1, LIM2
organic cyclic compound binding (GO:0097159)	1.05	7	HSF4, EPHA2, VIM, AGK, PITX3, TDRD7, MAF
heterocyclic compound binding (GO:1901363)	1.06	7	HSF4, EPHA2, VIM, AGK, PITX3, TDRD7, MAF
identical protein binding (GO:0042802)	2.63	7	CHMP4B, GJA3, CRYBA2, CRYAA, CRYAB, VIM, CRYBB2
nucleic acid binding (GO:0003676)	1.44	5	PITX3, VIM, TDRD7, MAF, HSF4
catalytic activity (GO:0003824)	1.05	4	LSS, EPHA2, GCNT2, AGK
protein dimerization activity (GO:0046983)	2.72	4	CHMP4B, CRYBB2, CRYAB, CRYBA2
protein homodimerization activity (GO:0042803)	3.16	4	CHMP4B, CRYBB2, CRYAB, CRYBA2
cation binding (GO:0043169)	1.4	3	FYCO1, CRYAB, CRYAA
structural constituent of cytoskeleton (GO:0005200)	5.12	3	VIM, BFSP1, BFSP2
sequence-specific DNA binding (GO:0043565)	2.79	3	PITX3, MAF, HSF4
carbohydrate derivative binding (GO:0097367)	2.03	3	EPHA2, VIM, AGK
transporter activity (GO:0005215)	2.57	3	MIP, GJA3, GJA8
transmembrane transporter activity (GO:0022857)	2.82	3	MIP, GJA3, GJA8
ion binding (GO:0043167)	1.36	3	CRYAA, CRYAB, FYCO1
transcription factor activity, sequence-specific DNA binding (GO:0003700)	2.65	3	PITX3, MAF, HSF4
transferase activity (GO:0016740)	1.95	3	EPHA2, GCNT2, AGK
channel activity (GO:0015267)	3.6	3	MIP, GJA3, GJA8
nucleic acid binding transcription factor activity (GO:0001071)	2.65	3	PITX3, MAF, HSF4
DNA binding (GO:0003677)	1.92	3	PITX3, MAF, HSF4
passive transmembrane transporter activity (GO:0022803)	3.6	3	MIP, GJA3, GJA8
metal ion binding (GO:0046872)	1.41	3	FYCO1, CRYAB, CRYAA
gap junction channel activity (GO:0005243)	7.1	3	MIP, GJA3, GJA8
wide pore channel activity (GO:0022829)	6.6	3	MIP, GJA3, GJA8
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	2	EPHA2, AGK
enzyme binding (GO:0019899)	2.27	2	WFS1, HSF4
nucleoside phosphate binding (GO:1901265)	1.96	2	EPHA2, AGK
nucleoside binding (GO:0001882)	2.21	2	EPHA2, AGK
unfolded protein binding (GO:0051082)	5.13	2	CRYAB, CRYAA
nucleotide binding (GO:0000166)	1.96	2	EPHA2, AGK
purine nucleoside binding (GO:0001883)	2.22	2	EPHA2, AGK
ribonucleoside binding (GO:0032549)	2.22	2	EPHA2, AGK
purine nucleotide binding (GO:0017076)	2.19	2	EPHA2, AGK
ATP binding (GO:0005524)	2.43	2	EPHA2, AGK
kinase activity (GO:0016301)	2.93	2	EPHA2, AGK
small molecule binding (GO:0036094)	1.89	2	EPHA2, AGK
adenyl nucleotide binding (GO:0030554)	2.4	2	EPHA2, AGK
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	2	EPHA2, AGK
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	2	EPHA2, AGK
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228)	3.98	2	PITX3, MAF
adenyl ribonucleotide binding (GO:0032559)	2.41	2	EPHA2, AGK
RNA binding (GO:0003723)	2.36	2	TDRD7, VIM
purine ribonucleotide binding (GO:0032555)	2.2	2	EPHA2, AGK
purine ribonucleoside binding (GO:0032550)	2.22	2	EPHA2, AGK
ribonucleotide binding (GO:0032553)	2.19	2	EPHA2, AGK
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981)	3.29	2	PITX3, MAF

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
structural constituent of eye lens (GO:0005212)	-	6.74	0.0	CRYAB, CRYGB, CRYGD, MIP, CRYAA, CRYBA2, CRYGS, CRYBB1, CRYBA1, CRYGC, VIM, CRYBB3, BFSP2, CRYBA4, CRYBB2, BFSP1, LIM2
structural molecule activity (GO:0005198)	-	3.1	0.0	CRYAB, CRYGD, HSF4, MIP, CRYAA, CRYBA2, CRYGB, CRYGS, CRYBB1, EPHA2, CRYBA1, CRYGC, VIM, CRYBB3, BFSP2, CRYBA4, CRYBB2, BFSP1, LIM2

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
single-organism process (GO:0044699)	0.48	29	GJA8, NHS, CRYGS, WFS1, UNC45B, CRYBA1, VIM, CRYGB, SIPA1L3, GJA3, HSF4, EPHA2, LIM2, AGK, TDRD7, CRYAB, MIP, GCNT2, CRYBA4, BFSP2, PITX3, BFSP1, CHMP4B, CRYGD, MAF, CRYBA2, LSS, CRYBB2, FYCO1
single-organism developmental process (GO:0044767)	1.49	24	CRYGB, NHS, CRYGS, WFS1, UNC45B, CRYBA1, VIM, GJA8, SIPA1L3, HSF4, EPHA2, LIM2, TDRD7, CRYAB, MIP, GCNT2, CRYBA4, BFSP2, PITX3, BFSP1, CRYGD, CRYBA2, CRYBB2, MAF
developmental process (GO:0032502)	1.36	24	CRYGB, NHS, CRYGS, WFS1, CRYBA4, CRYBA1, VIM, GJA8, SIPA1L3, HSF4, EPHA2, LIM2, TDRD7, CRYAB, MIP, GCNT2, UNC45B, BFSP2, PITX3, BFSP1, CRYGD, CRYBA2, CRYBB2, MAF
cellular process (GO:0009987)	0.26	24	CRYGB, NHS, CRYAA, WFS1, UNC45B, VIM, GJA8, SIPA1L3, GJA3, HSF4, EPHA2, LIM2, AGK, TDRD7, CRYAB, MIP, GCNT2, BFSP2, PITX3, BFSP1, CHMP4B, CRYGD, MAF, FYCO1
anatomical structure development (GO:0048856)	1.58	23	CRYGB, NHS, CRYGS, WFS1, UNC45B, CRYBA1, VIM, GJA8, SIPA1L3, HSF4, EPHA2, LIM2, CRYAB, MIP, GCNT2, CRYBA4, BFSP2, PITX3, BFSP1, CRYGD, CRYBA2, CRYBB2, MAF
single-organism cellular process (GO:0044763)	0.65	23	CRYGB, NHS, WFS1, UNC45B, VIM, GJA8, SIPA1L3, GJA3, HSF4, EPHA2, LIM2, AGK, TDRD7, CRYAB, MIP, GCNT2, BFSP2, PITX3, BFSP1, CHMP4B, CRYGD, FYCO1, MAF
multicellular organismal process (GO:0032501)	1.45	21	WFS1, GJA3, HSF4, MIP, CRYAA, CRYGB, GCNT2, CRYAB, UNC45B, CRYBA4, EPHA2, CRYBA1, CRYGC, BFSP2, CRYBB1, GJA8, PITX3, CRYBB2, MAF, CRYGD, CRYBB3
system process (GO:0003008)	2.3	16	CRYAB, GJA8, HSF4, MIP, CRYGC, CRYGB, CRYAA, WFS1, CRYBB1, GJA3, CRYBA1, CRYBA4, BFSP2, CRYBB2, CRYGD, CRYBB3
neurological system process (GO:0050877)	2.64	15	WFS1, GJA8, HSF4, MIP, CRYGC, CRYGB, CRYAA, CRYBB1, GJA3, CRYBA1, CRYBA4, BFSP2, CRYBB2, CRYGD, CRYBB3
biological regulation (GO:0065007)	0.39	15	CHMP4B, WFS1, HSF4, MIP, CRYAA, GCNT2, CRYAB, EPHA2, PITX3, CRYBA1, VIM, LSS, TDRD7, MAF, SIPA1L3
visual perception (GO:0007601)	4.41	15	WFS1, BFSP2, HSF4, MIP, CRYGC, CRYAA, CRYBA1, CRYBB1, GJA3, CRYGB, CRYBA4, GJA8, CRYBB2, CRYGD, CRYBB3
sensory perception (GO:0007600)	2.93	15	WFS1, BFSP2, HSF4, MIP, CRYGC, CRYAA, CRYBA1, CRYBB1, GJA3, CRYGB, CRYBA4, GJA8, CRYBB2, CRYGD, CRYBB3
sensory perception of light stimulus (GO:0050953)	4.4	15	WFS1, BFSP2, HSF4, MIP, CRYGC, CRYGB, CRYAA, CRYBB1, GJA3, CRYBA1, CRYBA4, GJA8, CRYBB2, CRYGD, CRYBB3
regulation of biological process (GO:0050789)	0.45	14	CHMP4B, HSF4, MIP, CRYAB, CRYAA, GCNT2, WFS1, EPHA2, CRYBA1, VIM, PITX3, TDRD7, MAF, SIPA1L3
lens development in camera-type eye (GO:0002088)	6.09	13	CRYAB, CRYGD, NHS, MIP, CRYGB, CRYBA2, CRYGS, UNC45B, CRYBA1, GJA8, PITX3, MAF, LIM2
cellular developmental process (GO:0048869)	1.82	13	NHS, HSF4, MAF, CRYGB, EPHA2, VIM, UNC45B, BFSP2, PITX3, TDRD7, BFSP1, CRYGD, SIPA1L3
cellular component organization (GO:0016043)	1.24	12	CRYAB, GJA8, HSF4, MIP, CRYAA, CHMP4B, CRYGB, EPHA2, VIM, SIPA1L3, BFSP2, LIM2
cellular component organization or biogenesis (GO:0071840)	1.22	12	CRYAB, GJA8, HSF4, MIP, CRYAA, CHMP4B, CRYGB, EPHA2, VIM, SIPA1L3, BFSP2, LIM2
regulation of cellular process (GO:0050794)	0.5	12	CHMP4B, WFS1, HSF4, CRYAA, GCNT2, CRYAB, EPHA2, CRYBA1, VIM, PITX3, MAF, SIPA1L3
primary metabolic process (GO:0044238)	0.69	10	CRYAB, HSF4, GCNT2, CHMP4B, EPHA2, PITX3, WFS1, AGK, LSS, MAF
regulation of metabolic process (GO:0019222)	1.02	10	CRYAB, HSF4, GCNT2, WFS1, EPHA2, CRYBA1, VIM, PITX3, TDRD7, MAF
regulation of macromolecule metabolic process (GO:0060255)	1.08	10	CRYAB, HSF4, GCNT2, WFS1, EPHA2, CRYBA1, VIM, PITX3, TDRD7, MAF
organic substance metabolic process (GO:0071704)	0.63	10	CRYAB, HSF4, GCNT2, CHMP4B, EPHA2, PITX3, WFS1, AGK, LSS, MAF
animal organ development (GO:0048513)	2.53	10	CRYAB, CRYGB, HSF4, WFS1, UNC45B, CRYBA4, SIPA1L3, GJA8, CRYBB2, LIM2
metabolic process (GO:0008152)	0.58	10	CRYAB, HSF4, GCNT2, CHMP4B, EPHA2, PITX3, WFS1, AGK, LSS, MAF
positive regulation of biological process (GO:0048518)	1.2	10	CHMP4B, HSF4, MIP, GCNT2, WFS1, EPHA2, CRYBA1, VIM, PITX3, MAF
negative regulation of biological process (GO:0048519)	1.33	10	CHMP4B, WFS1, HSF4, CRYAA, GCNT2, CRYAB, EPHA2, CRYBA1, VIM, MAF
negative regulation of cellular process (GO:0048523)	1.41	10	CHMP4B, WFS1, HSF4, CRYAA, GCNT2, CRYAB, EPHA2, CRYBA1, VIM, MAF
response to stimulus (GO:0050896)	1.22	9	CRYAB, CRYGD, GJA3, MIP, CRYAA, WFS1, EPHA2, BFSP2, CRYBB2
cell differentiation (GO:0030154)	2.14	9	CRYGD, NHS, UNC45B, EPHA2, VIM, PITX3, TDRD7, MAF, SIPA1L3
regulation of primary metabolic process (GO:0080090)	1.08	8	CRYAB, HSF4, GCNT2, WFS1, EPHA2, CRYBA1, PITX3, MAF
sensory organ development (GO:0007423)	4.82	8	CRYAB, GJA8, HSF4, CRYBA4, SIPA1L3, CRYGB, CRYBB2, LIM2
regulation of cellular metabolic process (GO:0031323)	1.07	8	CRYAB, HSF4, GCNT2, WFS1, EPHA2, CRYBA1, PITX3, MAF
cell development (GO:0048468)	3.28	8	CRYGB, HSF4, BFSP1, EPHA2, VIM, BFSP2, PITX3, MAF
cellular metabolic process (GO:0044237)	0.69	8	CRYAB, HSF4, GCNT2, WFS1, EPHA2, AGK, PITX3, MAF
macromolecule metabolic process (GO:0043170)	0.83	8	CHMP4B, HSF4, GCNT2, CRYAB, EPHA2, WFS1, PITX3, MAF
eye development (GO:0001654)	5.07	8	CRYAB, GJA8, HSF4, CRYBA4, SIPA1L3, CRYGB, CRYBB2, LIM2
regulation of gene expression (GO:0010468)	1.37	8	CRYAB, HSF4, GCNT2, WFS1, VIM, PITX3, TDRD7, MAF
positive regulation of cellular process (GO:0048522)	1.3	8	CHMP4B, HSF4, GCNT2, WFS1, EPHA2, CRYBA1, PITX3, MAF
cellular component assembly (GO:0022607)	2.14	7	CHMP4B, HSF4, MIP, CRYAA, CRYAB, GJA8, LIM2
cellular macromolecule metabolic process (GO:0044260)	0.93	7	CRYAB, HSF4, GCNT2, WFS1, EPHA2, PITX3, MAF
protein oligomerization (GO:0051259)	3.71	6	CHMP4B, HSF4, MIP, CRYAA, CRYAB, GJA8
organic substance biosynthetic process (GO:1901576)	1.34	6	HSF4, GCNT2, PITX3, AGK, LSS, MAF
positive regulation of metabolic process (GO:0009893)	1.74	6	WFS1, HSF4, GCNT2, VIM, PITX3, MAF
single-multicellular organism process (GO:0044707)	1.78	6	WFS1, GCNT2, UNC45B, EPHA2, PITX3, MAF
protein metabolic process (GO:0019538)	1.45	6	CHMP4B, HSF4, GCNT2, CRYAB, EPHA2, WFS1
protein homooligomerization (GO:0051260)	4.21	6	CHMP4B, HSF4, MIP, CRYAA, CRYAB, GJA8
protein complex assembly (GO:0006461)	2.78	6	CHMP4B, HSF4, MIP, CRYAA, CRYAB, GJA8
regulation of response to stimulus (GO:0048583)	1.54	6	CRYAB, GCNT2, WFS1, EPHA2, CRYBA1, SIPA1L3
macromolecular complex assembly (GO:0065003)	2.55	6	CHMP4B, HSF4, MIP, CRYAA, CRYAB, GJA8
macromolecular complex subunit organization (GO:0043933)	2.14	6	CHMP4B, HSF4, MIP, CRYAA, CRYAB, GJA8
biosynthetic process (GO:0009058)	1.32	6	HSF4, GCNT2, PITX3, AGK, LSS, MAF
protein complex subunit organization (GO:0071822)	2.6	6	CHMP4B, HSF4, MIP, CRYAA, CRYAB, GJA8
anatomical structure morphogenesis (GO:0009653)	2.53	6	CRYGS, EPHA2, CRYGB, PITX3, TDRD7, SIPA1L3
camera-type eye development (GO:0043010)	5.36	6	CRYAB, HSF4, CRYBA4, GJA8, CRYBB2, LIM2
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	6	WFS1, HSF4, GCNT2, VIM, PITX3, MAF
negative regulation of metabolic process (GO:0009892)	1.93	5	MAF, CRYBA1, CRYAB, WFS1, HSF4
positive regulation of cellular metabolic process (GO:0031325)	1.81	5	PITX3, MAF, WFS1, GCNT2, HSF4
negative regulation of cellular metabolic process (GO:0031324)	2.01	5	MAF, CRYBA1, CRYAB, WFS1, HSF4
regulation of cellular component organization (GO:0051128)	2.01	5	EPHA2, VIM, CHMP4B, GCNT2, CRYAB
nitrogen compound metabolic process (GO:0006807)	1.13	5	PITX3, GCNT2, MAF, HSF4, AGK
signal transduction (GO:0007165)	1.28	5	EPHA2, GCNT2, WFS1, VIM, CRYAB
regulation of intracellular signal transduction (GO:1902531)	2.31	5	EPHA2, CRYBA1, GCNT2, WFS1, SIPA1L3
regulation of signaling (GO:0023051)	1.72	5	EPHA2, CRYBA1, GCNT2, WFS1, SIPA1L3
regulation of cell communication (GO:0010646)	1.73	5	EPHA2, WFS1, GCNT2, CRYBA1, SIPA1L3
single-organism metabolic process (GO:0044710)	1.63	5	LSS, CRYAB, GCNT2, AGK, HSF4
regulation of localization (GO:0032879)	1.94	5	EPHA2, GCNT2, CRYAB, CRYAA, WFS1
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	5	MAF, CRYBA1, CRYAB, WFS1, HSF4
regulation of signal transduction (GO:0009966)	1.84	5	EPHA2, WFS1, GCNT2, CRYBA1, SIPA1L3
regulation of protein metabolic process (GO:0051246)	1.93	5	EPHA2, GCNT2, CRYBA1, CRYAB, WFS1
epithelial cell differentiation (GO:0030855)	3.98	5	PITX3, EPHA2, TDRD7, MAF, CRYGD
regulation of biological quality (GO:0065008)	1.68	5	MIP, LSS, CHMP4B, GCNT2, WFS1
transport (GO:0006810)	1.51	5	MIP, CHMP4B, FYCO1, GJA3, GJA8
response to stress (GO:0006950)	1.8	5	EPHA2, WFS1, CRYAB, CRYGD, GJA3
regulation of multicellular organismal process (GO:0051239)	1.87	5	EPHA2, GCNT2, CRYBA1, VIM, MAF
establishment of localization (GO:0051234)	1.48	5	MIP, CHMP4B, FYCO1, GJA3, GJA8
localization (GO:0051179)	1.4	5	MIP, CHMP4B, FYCO1, GJA3, GJA8
organelle organization (GO:0006996)	2.02	5	CHMP4B, CRYAB, VIM, SIPA1L3, BFSP2
regulation of cellular protein metabolic process (GO:0032268)	1.99	5	EPHA2, GCNT2, CRYBA1, CRYAB, WFS1
regulation of cell death (GO:0010941)	2.43	5	CRYAA, CHMP4B, CRYAB, WFS1, CRYBA1
protein folding (GO:0006457)	4.32	4	CRYAB, CRYAA, WFS1, UNC45B
positive regulation of biosynthetic process (GO:0009891)	2.29	4	PITX3, WFS1, MAF, HSF4
regulation of cellular biosynthetic process (GO:0031326)	1.38	4	PITX3, WFS1, MAF, HSF4
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	4	PITX3, WFS1, MAF, HSF4
homeostatic process (GO:0042592)	2.61	4	MIP, CHMP4B, GCNT2, WFS1
cellular biosynthetic process (GO:0044249)	1.37	4	PITX3, MAF, HSF4, AGK
negative regulation of gene expression (GO:0010629)	2.48	4	WFS1, MAF, CRYAB, HSF4
positive regulation of gene expression (GO:0010628)	2.35	4	PITX3, MAF, VIM, HSF4
regulation of cell differentiation (GO:0045595)	2.42	4	GCNT2, VIM, MAF, HSF4
regulation of phosphate metabolic process (GO:0019220)	2.35	4	EPHA2, CRYBA1, GCNT2, WFS1
organic cyclic compound biosynthetic process (GO:1901362)	1.66	4	PITX3, LSS, MAF, HSF4
multicellular organism development (GO:0007275)	2.54	4	PITX3, EPHA2, GCNT2, UNC45B
organic cyclic compound metabolic process (GO:1901360)	1.26	4	PITX3, LSS, MAF, HSF4
cellular protein metabolic process (GO:0044267)	1.63	4	EPHA2, CRYAB, GCNT2, HSF4
cellular response to stimulus (GO:0051716)	1.97	4	EPHA2, CRYAB, WFS1, CRYGD
regulation of apoptotic process (GO:0042981)	2.5	4	CRYAA, CRYBA1, CRYAB, WFS1
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	4	PITX3, WFS1, MAF, HSF4
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	4	PITX3, WFS1, MAF, HSF4
lens fiber cell differentiation (GO:0070306)	7.16	4	PITX3, TDRD7, MAF, CRYGD
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	4	PITX3, WFS1, MAF, HSF4
regulation of programmed cell death (GO:0043067)	2.49	4	CRYAA, CRYBA1, CRYAB, WFS1
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	4	PITX3, WFS1, MAF, HSF4
protein modification process (GO:0036211)	1.79	4	EPHA2, CRYAB, GCNT2, HSF4
regulation of protein modification process (GO:0031399)	2.32	4	EPHA2, CRYBA1, GCNT2, WFS1
regulation of molecular function (GO:0065009)	1.78	4	EPHA2, WFS1, CRYAB, SIPA1L3
cytoskeleton organization (GO:0007010)	3.22	4	CRYAB, VIM, BFSP2, SIPA1L3
epithelial cell development (GO:0002064)	4.92	4	VIM, BFSP1, BFSP2, CRYGB
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	4	PITX3, WFS1, MAF, HSF4
regulation of developmental process (GO:0050793)	2.1	4	EPHA2, VIM, MAF, GCNT2
negative regulation of cell death (GO:0060548)	2.95	4	CRYAA, CHMP4B, CRYAB, WFS1
regulation of catalytic activity (GO:0050790)	1.97	4	EPHA2, WFS1, CRYAB, SIPA1L3
regulation of biosynthetic process (GO:0009889)	1.37	4	PITX3, WFS1, MAF, HSF4
lens fiber cell development (GO:0070307)	7.53	4	BFSP1, VIM, BFSP2, CRYGB
cellular protein modification process (GO:0006464)	1.79	4	EPHA2, CRYAB, GCNT2, HSF4
regulation of phosphorus metabolic process (GO:0051174)	2.35	4	EPHA2, CRYBA1, GCNT2, WFS1
macromolecule modification (GO:0043412)	1.73	4	EPHA2, CRYAB, GCNT2, HSF4
macromolecule biosynthetic process (GO:0009059)	1.61	4	PITX3, GCNT2, MAF, HSF4
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	4	PITX3, WFS1, MAF, HSF4
regulation of RNA biosynthetic process (GO:2001141)	1.55	4	PITX3, WFS1, MAF, HSF4
response to chemical (GO:0042221)	1.98	4	EPHA2, CRYAB, CRYGD, GJA3
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	4	PITX3, MAF, HSF4, AGK
regulation of RNA metabolic process (GO:0051252)	1.52	4	PITX3, WFS1, MAF, HSF4
cellular nitrogen compound metabolic process (GO:0034641)	1.22	4	PITX3, MAF, HSF4, AGK
regulation of transcription, DNA-templated (GO:0006355)	1.56	4	PITX3, WFS1, MAF, HSF4
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	4	PITX3, WFS1, MAF, HSF4
regulation of multicellular organismal development (GO:2000026)	2.31	4	EPHA2, GCNT2, MAF, VIM
cellular response to stress (GO:0033554)	2.51	4	EPHA2, WFS1, CRYAB, CRYGD
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	4	PITX3, WFS1, MAF, HSF4
RNA biosynthetic process (GO:0032774)	1.84	3	PITX3, MAF, HSF4
negative regulation of biosynthetic process (GO:0009890)	2.47	3	WFS1, MAF, HSF4
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	3	WFS1, MAF, HSF4
regulation of transport (GO:0051049)	2.24	3	WFS1, CRYAA, CRYAB
negative regulation of response to stimulus (GO:0048585)	2.52	3	EPHA2, CRYBA1, WFS1
response to reactive oxygen species (GO:0000302)	4.5	3	CRYAB, GJA3, CRYGD
nucleic acid metabolic process (GO:0090304)	1.46	3	PITX3, MAF, HSF4
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	3	PITX3, MAF, HSF4
negative regulation of cell communication (GO:0010648)	2.66	3	EPHA2, CRYBA1, WFS1
cellular macromolecule biosynthetic process (GO:0034645)	1.66	3	PITX3, MAF, HSF4
regulation of hydrolase activity (GO:0051336)	2.53	3	EPHA2, CRYAB, SIPA1L3
nucleic acid-templated transcription (GO:0097659)	1.91	3	PITX3, MAF, HSF4
regulation of MAPK cascade (GO:0043408)	3.22	3	EPHA2, CRYBA1, GCNT2
nucleobase-containing compound metabolic process (GO:0006139)	1.35	3	PITX3, MAF, HSF4
cell morphogenesis involved in differentiation (GO:0000904)	4.67	3	EPHA2, CRYGB, SIPA1L3
cell morphogenesis (GO:0000902)	4.35	3	EPHA2, CRYGB, SIPA1L3
negative regulation of signal transduction (GO:0009968)	2.75	3	EPHA2, CRYBA1, WFS1
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	3.12	3	WFS1, MAF, HSF4
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	3	PITX3, MAF, HSF4
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	3	WFS1, MAF, HSF4
cellular component morphogenesis (GO:0032989)	3.5	3	EPHA2, SIPA1L3, CRYGB
interspecies interaction between organisms (GO:0044419)	3.08	3	EPHA2, CHMP4B, VIM
negative regulation of apoptotic process (GO:0043066)	3.04	3	WFS1, CRYAA, CRYAB
positive regulation of catalytic activity (GO:0043085)	2.4	3	EPHA2, WFS1, SIPA1L3
positive regulation of molecular function (GO:0044093)	2.23	3	EPHA2, WFS1, SIPA1L3
phosphorylation (GO:0016310)	2.63	3	EPHA2, CRYAB, AGK
multi-organism process (GO:0051704)	2.65	3	EPHA2, CHMP4B, VIM
negative regulation of programmed cell death (GO:0043069)	3.02	3	WFS1, CRYAA, CRYAB
regulation of cell adhesion (GO:0030155)	3.27	3	MIP, EPHA2, GCNT2
heterocycle biosynthetic process (GO:0018130)	1.7	3	PITX3, MAF, HSF4
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	3	PITX3, MAF, HSF4
RNA metabolic process (GO:0016070)	1.59	3	PITX3, MAF, HSF4
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	3	WFS1, MAF, HSF4
cellular aromatic compound metabolic process (GO:0006725)	1.3	3	PITX3, MAF, HSF4
regulation of cellular localization (GO:0060341)	3.03	3	EPHA2, CRYAB, CRYAA
negative regulation of nucleic acid-templated transcription (GO:1903507)	2.71	3	WFS1, MAF, HSF4
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	3	WFS1, MAF, HSF4
single-organism transport (GO:0044765)	2.18	3	MIP, CHMP4B, FYCO1
multi-organism cellular process (GO:0044764)	3.14	3	EPHA2, CHMP4B, VIM
negative regulation of transcription, DNA-templated (GO:0045892)	2.75	3	WFS1, MAF, HSF4
response to oxygen-containing compound (GO:1901700)	2.57	3	CRYAB, CRYGD, GJA3
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	3	WFS1, MAF, HSF4
single-organism organelle organization (GO:1902589)	2.68	3	CRYAB, VIM, BFSP2
negative regulation of intracellular signal transduction (GO:1902532)	3.63	3	EPHA2, CRYBA1, WFS1
movement of cell or subcellular component (GO:0006928)	2.61	3	EPHA2, VIM, FYCO1
regulation of protein kinase B signaling (GO:0051896)	4.92	3	EPHA2, CRYBA1, GCNT2
response to oxidative stress (GO:0006979)	3.9	3	CRYAB, GJA3, CRYGD
single-organism localization (GO:1902578)	2.09	3	MIP, CHMP4B, FYCO1
heterocycle metabolic process (GO:0046483)	1.31	3	PITX3, MAF, HSF4
regulation of phosphorylation (GO:0042325)	2.5	3	EPHA2, CRYBA1, GCNT2
transmembrane transport (GO:0055085)	2.72	3	MIP, GJA3, GJA8
aromatic compound biosynthetic process (GO:0019438)	1.7	3	PITX3, MAF, HSF4
negative regulation of RNA metabolic process (GO:0051253)	2.66	3	WFS1, MAF, HSF4
positive regulation of RNA metabolic process (GO:0051254)	2.51	3	PITX3, MAF, HSF4
regulation of ERK1 and ERK2 cascade (GO:0070372)	4.23	3	EPHA2, CRYBA1, GCNT2
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	3	PITX3, MAF, HSF4
phosphate-containing compound metabolic process (GO:0006796)	2.16	3	EPHA2, CRYAB, AGK
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	3	PITX3, MAF, HSF4
transcription, DNA-templated (GO:0006351)	1.91	3	PITX3, MAF, HSF4
viral process (GO:0016032)	3.15	3	EPHA2, CHMP4B, VIM
phosphorus metabolic process (GO:0006793)	2.15	3	EPHA2, CRYAB, AGK
symbiosis, encompassing mutualism through parasitism (GO:0044403)	3.15	3	EPHA2, CHMP4B, VIM
regulation of protein phosphorylation (GO:0001932)	2.57	3	EPHA2, CRYBA1, GCNT2
negative regulation of signaling (GO:0023057)	2.65	3	EPHA2, CRYBA1, WFS1
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	3	WFS1, MAF, HSF4
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	3	PITX3, MAF, HSF4
anatomical structure homeostasis (GO:0060249)	4.25	2	CHMP4B, GCNT2
regulation of intracellular transport (GO:0032386)	3.58	2	CRYAB, CRYAA
negative regulation of intracellular transport (GO:0032387)	5.02	2	CRYAB, CRYAA
cellular chemical homeostasis (GO:0055082)	3.4	2	MIP, WFS1
cell maturation (GO:0048469)	4.98	2	BFSP1, BFSP2
negative regulation of protein kinase B signaling (GO:0051898)	6.12	2	EPHA2, CRYBA1
cell surface receptor signaling pathway (GO:0007166)	2.09	2	EPHA2, GCNT2
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	2	EPHA2, GCNT2
establishment of organelle localization (GO:0051656)	4.15	2	CHMP4B, FYCO1
regulation of cell projection organization (GO:0031344)	3.38	2	EPHA2, VIM
muscle organ development (GO:0007517)	4.98	2	CRYAB, UNC45B
single-organism biosynthetic process (GO:0044711)	2.8	2	LSS, AGK
positive regulation of cell adhesion (GO:0045785)	3.79	2	MIP, GCNT2
posttranscriptional regulation of gene expression (GO:0010608)	3.64	2	TDRD7, GCNT2
negative regulation of molecular function (GO:0044092)	2.74	2	WFS1, CRYAB
regulation of cell proliferation (GO:0042127)	2.41	2	GCNT2, HSF4
negative regulation of transport (GO:0051051)	3.6	2	CRYAB, CRYAA
response to inorganic substance (GO:0010035)	3.56	2	CRYAB, GJA3
response to organic substance (GO:0010033)	2.2	2	EPHA2, CRYAB
single organism signaling (GO:0044700)	3.25	2	GJA3, GJA8
organonitrogen compound metabolic process (GO:1901564)	2.32	2	GCNT2, AGK
organonitrogen compound biosynthetic process (GO:1901566)	2.85	2	GCNT2, AGK
intermediate filament cytoskeleton organization (GO:0045104)	6.04	2	VIM, BFSP2
chemical homeostasis (GO:0048878)	2.97	2	MIP, WFS1
positive regulation of GTPase activity (GO:0043547)	3.28	2	EPHA2, SIPA1L3
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	2	EPHA2, GCNT2
intracellular signal transduction (GO:0035556)	2.39	2	EPHA2, CRYAB
intermediate filament-based process (GO:0045103)	6.02	2	VIM, BFSP2
developmental maturation (GO:0021700)	4.7	2	BFSP1, BFSP2
positive regulation of phosphate metabolic process (GO:0045937)	2.78	2	WFS1, GCNT2
positive regulation of hydrolase activity (GO:0051345)	2.91	2	EPHA2, SIPA1L3
transcription from RNA polymerase II promoter (GO:0006366)	3.38	2	PITX3, MAF
positive regulation of cellular component organization (GO:0051130)	2.68	2	EPHA2, GCNT2
organ morphogenesis (GO:0009887)	3.55	2	PITX3, EPHA2
lipid metabolic process (GO:0006629)	2.68	2	LSS, AGK
programmed cell death (GO:0012501)	3.1	2	EPHA2, CRYAB
regulation of neuron death (GO:1901214)	4.19	2	CHMP4B, WFS1
negative regulation of neuron death (GO:1901215)	4.57	2	CHMP4B, WFS1
proteolysis involved in cellular protein catabolic process (GO:0051603)	3.59	2	CHMP4B, WFS1
intracellular transport (GO:0046907)	2.67	2	CHMP4B, FYCO1
response to hydrogen peroxide (GO:0042542)	5.02	2	CRYAB, GJA3
regulation of response to stress (GO:0080134)	2.53	2	WFS1, CRYAB
regulation of cellular response to stress (GO:0080135)	3.4	2	WFS1, CRYAB
regulation of cell motility (GO:2000145)	3.16	2	EPHA2, GCNT2
positive regulation of protein modification process (GO:0031401)	2.7	2	WFS1, GCNT2
negative regulation of cellular component organization (GO:0051129)	3.35	2	CHMP4B, VIM
water homeostasis (GO:0030104)	5.48	2	MIP, WFS1
signaling (GO:0023052)	3.25	2	GJA3, GJA8
muscle structure development (GO:0061061)	4.96	2	CRYAB, UNC45B
regulation of GTPase activity (GO:0043087)	3.21	2	EPHA2, SIPA1L3
negative regulation of protein metabolic process (GO:0051248)	2.82	2	CRYBA1, CRYAB
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	2	WFS1, GCNT2
negative regulation of multicellular organismal process (GO:0051241)	2.84	2	CRYBA1, VIM
positive regulation of protein metabolic process (GO:0051247)	2.43	2	WFS1, GCNT2
regulation of cell development (GO:0060284)	3.01	2	VIM, GCNT2
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	2	WFS1, GCNT2
proteolysis (GO:0006508)	2.73	2	CHMP4B, WFS1
lipid biosynthetic process (GO:0008610)	3.49	2	LSS, AGK
positive regulation of cell proliferation (GO:0008284)	3.01	2	GCNT2, HSF4
lens fiber cell morphogenesis (GO:0070309)	8.34	2	EPHA2, CRYGB
maintenance of lens transparency (GO:0036438)	8.34	2	CHMP4B, GCNT2
positive regulation of cell differentiation (GO:0045597)	3.01	2	GCNT2, HSF4
regulation of cellular component movement (GO:0051270)	3.08	2	EPHA2, GCNT2
tissue homeostasis (GO:0001894)	4.78	2	CHMP4B, GCNT2
negative regulation of cellular protein metabolic process (GO:0032269)	2.88	2	CRYBA1, CRYAB
cellular homeostasis (GO:0019725)	3.23	2	MIP, WFS1
regulation of protein stability (GO:0031647)	4.33	2	LSS, WFS1
lens morphogenesis in camera-type eye (GO:0002089)	7.16	2	PITX3, TDRD7
cell death (GO:0008219)	3.05	2	EPHA2, CRYAB
morphogenesis of an epithelium (GO:0002009)	4.08	2	EPHA2, CRYGS
regulation of growth (GO:0040008)	3.26	2	WFS1, CRYAB
regulation of locomotion (GO:0040012)	3.12	2	EPHA2, GCNT2
tissue morphogenesis (GO:0048729)	3.87	2	EPHA2, CRYGS
organic substance transport (GO:0071702)	2.15	2	MIP, CHMP4B
protein phosphorylation (GO:0006468)	2.89	2	EPHA2, CRYAB
regulation of cell migration (GO:0030334)	3.23	2	EPHA2, GCNT2
neuron differentiation (GO:0030182)	4.17	2	PITX3, EPHA2
apoptotic process (GO:0006915)	3.14	2	EPHA2, CRYAB
establishment of localization in cell (GO:0051649)	2.47	2	CHMP4B, FYCO1
cell-cell signaling (GO:0007267)	3.35	2	GJA3, GJA8
cell communication (GO:0007154)	3.04	2	GJA3, GJA8
organelle localization (GO:0051640)	3.94	2	CHMP4B, FYCO1
cellular localization (GO:0051641)	2.32	2	CHMP4B, FYCO1
response to abiotic stimulus (GO:0009628)	2.8	2	CRYAB, GJA3
microtubule-based process (GO:0007017)	3.54	2	CRYAB, FYCO1
regulation of cellular component biogenesis (GO:0044087)	3.08	2	EPHA2, CHMP4B
single-organism intracellular transport (GO:1902582)	3.59	2	CHMP4B, FYCO1
single-organism cellular localization (GO:1902580)	3.16	2	CHMP4B, FYCO1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
cell development (GO:0048468)	-	3.28	0.003	HSF4, BFSP1, EPHA2, VIM, BFSP2, PITX3, TDRD7, MAF
lens fiber cell morphogenesis (GO:0070309)	-	8.34	0.014	EPHA2, CRYGB
lens development in camera-type eye (GO:0002088)	-	6.09	0.0	CRYAB, CRYGD, NHS, MIP, CRYBA2, CRYGS, CRYBB1, CRYBA1, VIM, LIM2, GJA8, PITX3, CRYBB2, CRYBB3
single-organism process (GO:0044699)	-	0.48	0.0	GJA8, NHS, CRYGS, WFS1, UNC45B, CRYBA1, VIM, CRYGB, SIPA1L3, GJA3, HSF4, CRYGC, EPHA2, LIM2, AGK, TDRD7, CRYAB, MIP, CRYAA, GCNT2, CRYBB3, CRYBA4, BFSP2, PITX3, CRYBB1, BFSP1, CHMP4B, CRYGD, MAF, CRYBA2, LSS, CRYBB2, FYCO1
cellular developmental process (GO:0048869)	-	1.82	0.032	CRYAB, NHS, HSF4, MAF, UNC45B, EPHA2, CRYGB, VIM, BFSP2, PITX3, TDRD7, BFSP1, CRYGD, SIPA1L3
protein homooligomerization (GO:0051260)	-	4.21	0.048	CHMP4B, CRYAA, CRYAB, GJA8, HSF4
developmental process (GO:0032502)	-	1.36	0.0	CRYGB, NHS, CRYGS, WFS1, UNC45B, CRYBA1, VIM, GJA8, SIPA1L3, HSF4, CRYGC, EPHA2, LIM2, TDRD7, CRYAB, MIP, GCNT2, CRYBA4, BFSP2, PITX3, BFSP1, CRYGD, CRYBA2, CRYBB2, MAF
multicellular organismal process (GO:0032501)	-	1.45	0.002	CRYAB, GJA8, GJA3, MIP, CRYAA, CRYGB, GCNT2, WFS1, CRYBB1, EPHA2, CRYBA1, CRYGC, CRYBA4, BFSP2, CRYBB2, MAF, CRYGD, CRYBB3
lens fiber cell differentiation (GO:0070306)	-	7.16	0.0	PITX3, TDRD7, MAF, CRYGD
neurological system process (GO:0050877)	-	2.64	0.0	CRYAB, GJA8, GJA3, MIP, CRYGC, CRYGB, CRYAA, WFS1, CRYBB1, CRYBA1, VIM, CRYBA4, BFSP2, PITX3, CRYBB2, BFSP1, CRYGD, CRYBB3
visual perception (GO:0007601)	-	4.41	0.0	CRYBA1, CRYAB, GJA8, GJA3, MIP, CRYGC, CRYAA, WFS1, CRYBB1, CRYGB, VIM, CRYBA4, BFSP2, CRYBB2, BFSP1, CRYGD, CRYBB3
lens fiber cell development (GO:0070307)	-	7.53	0.0	BFSP1, VIM, BFSP2
sensory perception of light stimulus (GO:0050953)	-	4.4	0.0	CRYAB, GJA8, GJA3, MIP, CRYAA, CRYGB, CRYGC, WFS1, CRYBB1, CRYBA1, VIM, CRYBA4, BFSP2, CRYBB2, BFSP1, CRYGD, CRYBB3
sensory perception (GO:0007600)	-	2.93	0.0	CRYBA1, CRYAB, GJA8, GJA3, MIP, CRYGC, CRYAA, WFS1, CRYBB1, CRYGB, VIM, CRYBA4, BFSP2, CRYBB2, BFSP1, CRYGD, CRYBB3
single-organism developmental process (GO:0044767)	-	1.49	0.0	CRYGB, NHS, CRYGS, WFS1, UNC45B, CRYBA1, VIM, GJA8, SIPA1L3, HSF4, CRYGC, EPHA2, LIM2, TDRD7, CRYAB, MIP, GCNT2, CRYBA4, BFSP2, PITX3, BFSP1, CRYGD, CRYBA2, CRYBB2, MAF
eye development (GO:0001654)	-	5.07	0.01	CRYAB, HSF4, CRYGC, CRYBB1, VIM, CRYBA4, CRYBB2
system process (GO:0003008)	-	2.3	0.0	WFS1, GJA8, GJA3, MIP, CRYGC, CRYGB, CRYAA, CRYAB, CRYBB1, CRYBA1, CRYBA4, BFSP2, CRYBB2, CRYGD, CRYBB3
single-multicellular organism process (GO:0044707)	-	1.78	0.002	CRYAB, GJA8, GJA3, MIP, CRYAA, CRYGB, GCNT2, WFS1, CRYBB1, EPHA2, CRYBA1, CRYGC, CRYBA4, BFSP2, CRYBB2, MAF, CRYGD, CRYBB3
sensory organ development (GO:0007423)	-	4.82	0.028	CRYAB, HSF4, CRYGC, CRYBB1, VIM, CRYBA4, CRYBB2
anatomical structure development (GO:0048856)	-	1.58	0.0	NHS, CRYGS, WFS1, CRYBA4, CRYBA1, VIM, GJA8, LIM2, HSF4, CRYGC, EPHA2, TDRD7, CRYAB, MIP, UNC45B, BFSP2, PITX3, BFSP1, CRYGD, CRYBA2, CRYBB2, MAF
camera-type eye development (GO:0043010)	-	5.36	0.0	CRYAB, HSF4, CRYGC, CRYBB1, VIM, CRYBA4, CRYBB2

GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	27	GJA8, NHS, CRYAA, WFS1, UNC45B, CRYBA1, VIM, CRYGB, SIPA1L3, GJA3, HSF4, CRYGC, EPHA2, LIM2, AGK, TDRD7, CRYAB, MIP, GCNT2, BFSP2, PITX3, BFSP1, CHMP4B, CRYGD, MAF, LSS, FYCO1
intracellular part (GO:0044424)	0.28	23	NHS, CRYAA, WFS1, UNC45B, CRYBA1, VIM, CRYGB, SIPA1L3, HSF4, CRYGC, AGK, TDRD7, CRYAB, MIP, GCNT2, BFSP2, PITX3, BFSP1, CHMP4B, CRYGD, MAF, LSS, FYCO1
organelle (GO:0043226)	0.4	21	LSS, WFS1, CRYGB, HSF4, MIP, CRYAA, GCNT2, CRYAB, CHMP4B, CRYBA1, CRYGC, VIM, FYCO1, AGK, CRYGD, PITX3, BFSP2, TDRD7, BFSP1, MAF, LIM2
intracellular organelle (GO:0043229)	0.51	20	LSS, CRYAB, CRYGB, HSF4, MIP, CRYAA, GCNT2, WFS1, CHMP4B, CRYBA1, CRYGC, VIM, FYCO1, AGK, CRYGD, PITX3, BFSP2, TDRD7, BFSP1, MAF
membrane-bounded organelle (GO:0043227)	0.47	19	WFS1, CRYGB, HSF4, MIP, CRYAA, FYCO1, GCNT2, CHMP4B, LSS, CRYBA1, CRYGC, VIM, CRYAB, AGK, CRYGD, PITX3, BFSP1, MAF, LIM2
intracellular membrane-bounded organelle (GO:0043231)	0.6	18	CHMP4B, CRYGD, HSF4, MIP, CRYAB, CRYAA, GCNT2, WFS1, CRYGB, PITX3, CRYBA1, CRYGC, VIM, FYCO1, AGK, LSS, BFSP1, MAF
membrane (GO:0016020)	0.68	17	WFS1, GJA8, AGK, GJA3, MIP, CRYAB, FYCO1, NHS, GCNT2, CHMP4B, EPHA2, VIM, SIPA1L3, BFSP2, LSS, BFSP1, LIM2
cytoplasm (GO:0005737)	1.01	14	CRYAB, CRYGD, NHS, MAF, CRYAA, CHMP4B, UNC45B, CRYBA1, CRYGC, VIM, CRYGB, BFSP2, TDRD7, BFSP1
intracellular organelle part (GO:0044446)	0.81	13	CHMP4B, WFS1, AGK, HSF4, MAF, GCNT2, CRYAB, VIM, BFSP2, LSS, TDRD7, BFSP1, SIPA1L3
cytoplasmic part (GO:0044444)	0.82	13	CHMP4B, BFSP2, MIP, CRYAB, GCNT2, WFS1, UNC45B, VIM, FYCO1, AGK, LSS, TDRD7, BFSP1
organelle part (GO:0044422)	0.79	13	CHMP4B, WFS1, BFSP2, HSF4, MAF, GCNT2, CRYAB, VIM, AGK, LSS, TDRD7, BFSP1, SIPA1L3
membrane part (GO:0044425)	0.95	12	CHMP4B, NHS, GJA3, MIP, GCNT2, WFS1, EPHA2, SIPA1L3, GJA8, LSS, FYCO1, LIM2
plasma membrane (GO:0005886)	1.39	11	CRYAB, GJA8, GJA3, MIP, NHS, EPHA2, VIM, SIPA1L3, BFSP2, BFSP1, LIM2
nucleus (GO:0005634)	1.07	10	CHMP4B, CRYGD, HSF4, CRYGC, CRYAA, CRYAB, CRYBA1, CRYGB, PITX3, MAF
integral component of membrane (GO:0016021)	1.14	8	WFS1, GJA3, MIP, GCNT2, EPHA2, GJA8, FYCO1, LIM2
intrinsic component of membrane (GO:0031224)	1.13	8	WFS1, GJA3, MIP, GCNT2, EPHA2, GJA8, FYCO1, LIM2
cell junction (GO:0030054)	2.75	8	GJA3, NHS, MIP, EPHA2, VIM, SIPA1L3, GJA8, LIM2
plasma membrane part (GO:0044459)	1.95	7	CHMP4B, GJA3, NHS, MIP, EPHA2, GJA8, SIPA1L3
non-membrane-bounded organelle (GO:0043228)	1.76	6	CRYAB, VIM, BFSP2, LSS, TDRD7, BFSP1
macromolecular complex (GO:0032991)	1.35	6	CHMP4B, GJA3, WFS1, GJA8, TDRD7, MAF
vesicle (GO:0031982)	1.64	6	CHMP4B, CRYAA, CRYAB, VIM, FYCO1, LIM2
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	6	CRYAB, VIM, BFSP2, LSS, TDRD7, BFSP1
cytoskeletal part (GO:0044430)	2.49	5	VIM, CRYAB, BFSP1, BFSP2, SIPA1L3
extracellular region part (GO:0044421)	1.57	5	VIM, CHMP4B, CRYAA, CRYAB, SIPA1L3
cell-cell junction (GO:0005911)	3.85	5	MIP, NHS, SIPA1L3, GJA8, GJA3
protein complex (GO:0043234)	1.51	4	CHMP4B, WFS1, GJA8, GJA3
plasma membrane region (GO:0098590)	2.97	4	MIP, EPHA2, NHS, SIPA1L3
extracellular vesicle (GO:1903561)	1.89	4	CRYAA, CHMP4B, VIM, CRYAB
extracellular organelle (GO:0043230)	1.89	4	VIM, CHMP4B, CRYAA, CRYAB
extracellular exosome (GO:0070062)	1.89	4	CRYAA, CHMP4B, VIM, CRYAB
cytosol (GO:0005829)	1.68	4	CHMP4B, VIM, CRYAB, UNC45B
cytoskeleton (GO:0005856)	2.55	4	BFSP1, CRYAB, VIM, BFSP2
membrane-bounded vesicle (GO:0031988)	1.71	4	VIM, CHMP4B, CRYAA, CRYAB
cell projection (GO:0042995)	2.47	4	EPHA2, WFS1, VIM, NHS
supramolecular fiber (GO:0099512)	3.31	3	VIM, BFSP1, BFSP2
polymeric cytoskeletal fiber (GO:0099513)	3.31	3	BFSP1, VIM, BFSP2
adherens junction (GO:0005912)	3.66	3	EPHA2, VIM, NHS
apical plasma membrane (GO:0016324)	4.13	3	MIP, NHS, SIPA1L3
intrinsic component of plasma membrane (GO:0031226)	2.53	3	MIP, EPHA2, GJA8
bounding membrane of organelle (GO:0098588)	2.39	3	CHMP4B, GCNT2, AGK
anchoring junction (GO:0070161)	3.61	3	EPHA2, VIM, NHS
mitochondrion (GO:0005739)	2.42	3	CRYAB, BFSP1, AGK
membrane protein complex (GO:0098796)	2.84	3	CHMP4B, GJA3, GJA8
intermediate filament (GO:0005882)	4.48	3	BFSP1, VIM, BFSP2
nuclear part (GO:0044428)	1.55	3	CHMP4B, CRYAB, HSF4
organelle membrane (GO:0031090)	1.97	3	CHMP4B, GCNT2, AGK
integral component of plasma membrane (GO:0005887)	2.57	3	MIP, EPHA2, GJA8
endoplasmic reticulum (GO:0005783)	2.56	3	MIP, LSS, WFS1
cell-substrate adherens junction (GO:0005924)	3.83	3	EPHA2, VIM, NHS
focal adhesion (GO:0005925)	3.83	3	EPHA2, VIM, NHS
gap junction (GO:0005921)	6.34	3	MIP, GJA3, GJA8
cell-substrate junction (GO:0030055)	3.82	3	EPHA2, VIM, NHS
actin filament bundle (GO:0032432)	5.74	2	CRYAB, SIPA1L3
Golgi apparatus (GO:0005794)	2.7	2	CRYAB, GCNT2
plasma membrane protein complex (GO:0098797)	3.55	2	GJA3, GJA8
neuron part (GO:0097458)	2.64	2	WFS1, VIM
vacuole (GO:0005773)	2.92	2	CHMP4B, FYCO1
endosome (GO:0005768)	3.25	2	CHMP4B, FYCO1
occluding junction (GO:0070160)	5.07	2	NHS, SIPA1L3
cytoplasmic region (GO:0099568)	4.51	2	BFSP1, BFSP2
endoplasmic reticulum membrane (GO:0005789)	2.95	2	LSS, WFS1
nucleoplasm (GO:0005654)	1.89	2	CRYAB, HSF4
endoplasmic reticulum part (GO:0044432)	2.73	2	LSS, WFS1
mitochondrial part (GO:0044429)	2.92	2	TDRD7, AGK
neuron projection (GO:0043005)	3.12	2	WFS1, VIM
whole membrane (GO:0098805)	2.85	2	CHMP4B, AGK
connexon complex (GO:0005922)	6.71	2	GJA3, GJA8
cell surface (GO:0009986)	3.44	2	EPHA2, CRYAB
cell cortex (GO:0005938)	4.78	2	BFSP1, BFSP2