Disease table of GASTRIC CANCER OMIM ID: 613659

Gene-disease associations table

GeneAssociated with GASTRIC CANCER inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
ERBB2OMIMHGNC link17q123PS137800, 613659, 211980
MUTYHOMIM, HUMSAVARHGNC link1p34.13132600, 613659, PS175100
IRF1OMIM, HUMSAVARHGNC link5q31.12613659, 211980
PIK3CAOMIMHGNC link3q26.3211114550, PS158350, 167000, 612918, 211980, 114480, 602501, 114500, 182000, 162900, 613659
CASP10OMIM, HUMSAVARHGNC link2q33.13603909, 613659, 605027
KLF6OMIMHGNC link10p15.22613659, 176807
APCOMIM, HUMSAVARHGNC link5q22.26114550, PS175100, 155255, 135290, 114500, 613659
FGFR2OMIMHGNC link10q26.1311101400, 101200, 149730, 614592, 123500, 207410, 613659, 123150, 609579, 101600, 123790
KRASHUMSAVARHGNC link12p12.114601626, 600268, 137215, 109800, PS163950, 211980, 114480, PS115150, 613659, 163200, 607785, 614470, 162900, 260350

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
5q2IRF1, APC
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
102KLF6, FGFR2
52IRF1, APC
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
IRF1YES51EIF2AK2, IFNA13, PSMB10, IL12A, NCF2, CEACAM1, MMP9, MYB, PSMB9, IL12B, TAP2, CCNE1, CCL5, SOCS2, VCAM1, TNFSF10, SOCS1, MAPK14, IFNA1, HLA-G, CASP7, CDKN1A, IFNB1, CCNB1, FOXP3, OGN, PIGR, IL10, TAP1, TP53, TRIM22, HLA-A, DDX58, CD40, ERAP2, IL27, CDK1, E2F1, TAPBP, CYBB, CDK2, BCL2, CDK4, CXCL10, SLPI, IRF2, DST, IFIT3, CIITA, IFNG, FASLG0
KLF6YES16NOS2, DAPK2, ATF3, PTTG1, CCND1, PMAIP1, CDKN1A, CDH1, ASAH1, TFPI2, MMP9, CERS2, KRT12, PSG5, LTC4S, TXNIP0
APCYES11PTGS2, NOS2, KLF4, BIRC5, SPP1, DNMT1, AKT1, MYC, AMHR2, ODC1, SGK10
YY1NO74FCER1A, CFTR, EGFR, GDAP1, POSTN, TP53, ATP2C1, IFNG, ADORA2A, KIR3DL1, TOP3A, HBE1, LDLR, SERPINE1, LRIG2, HSPA5, GBP1, HLA-DRA, APC, HAS2, CCL13, SNRPN, FMO3, TFRC, CTCF, FAS, TF, CXCR4, FCGR3B, DNAJB4, HSD3B2, ERBB2, SURF1, TDO2, IVL, BRCA1, DEK, COX7C, CETP, ERCC5, NOS2, BDKRB1, SLC26A3, EPAS1, ACTC1, ZNF175, BAP1, TNFRSF10B, HOXB7, NF1, OPRM1, PCNA, PARP1, PRDM2, VWF, TP73, CCR5, CBX5, SURF2, IL4, NR3C1, PDIA6, CYP3A5, CREBBP, HCFC1, IL5, DBH, RB1, FDPS, FCGR2B, LSS, MYC, HOXB13, COL1A22APC, ERBB2
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
ERBB2YES30AR, WWP1, ECD, TFAP2A, PAX2, MYB, PURA, PGR, JUND, SP1, ETV4, GATA4, NCOA3, CREB1, VDR, TFAP2B, ATF7, ELK1, FOXP3, ATF1, EP300, ELF1, GABPA, YY1, XRCC6, TFAP2C, YBX1, SP3, SP4, XRCC50
IRF1YES8STAT3, STAT2, NFKB1, CREBBP, RELA, CIITA, STAT4, STAT10
PIK3CAYES1FOXO30
KLF6YES1NR1I20
APCYES6YY1, USF2, CEBPZ, EZH2, CDX2, USF10
KRASYES1MYC0
CDKN1ANO118ABL1, TFAP4, TP53, MYF5, TCF3, HDAC9, PAX5, ZBTB2, LCOR, E2F3, ZBTB5, HSF1, ELL, TSC22D3, NCOA1, TAF1, RELA, MYOD1, STAT1, PTTG1, KLF16, ESR1, JUNB, MYCN, KAT2B, AR, BCL6, KLF10, EZH2, ARID1A, JUND, SP1, CEBPB, ZFHX3, ZNF300, EGR1, KLF4, AATF, HDAC7, HBP1, SMARCA4, ESR2, FOXP3, RARA, NELFCD, ING4, HDAC4, TBX2, IRF1, HDAC2, ETV6, SIRT2, MYOG, KLF6, TP73, SOX6, ATM, ERCC2, SMAD4, ETS2, NUPR1, PTMA, MLLT10, SMAD3, ETS1, CBX8, BRCA1, HIPK2, SIRT1, WT1, ZNF76, HDAC1, SMAD2, MLLT3, TFAP2A, EP300, FHL2, TP63, IRF9, EHMT2, TFAP2C, NFIX, RUNX3, RB1, HNF4A, NFIB, TAF5, SOX9, TBP, EAPP, ZBTB17, TAF4, REL, RELB, PML, SMAD7, NPM1, POU5F1, E2F1, TBX3, FOXG1, MYF6, NFIA, ATF2, PARP1, NFKB1, STAT3, GFI1, NR3C1, CREBBP, MTA1, JUN, KLF2, CDX2, SP3, MYC, PPARG, ING12IRF1, KLF6
NOS2NO16APC, XBP1, STAT2, RELA, MTA1, NFKB1, YY1, FOSL2, IKBKB, NFKBIA, JUN, KLF6, JUND, FOS, KLF5, STAT12APC, KLF6
MMP9NO31MAZ, TFAP2A, SNAI2, FOS, SP1, ELF4, SPDEF, KLF5, MTA1, SMAD3, STAT1, SP2, PPARA, SIRT1, EP300, HDAC1, ELF3, IKBKB, ETS2, RELA, NFKB1, ETS1, STAT3, IRF1, JUN, NFKBIA, RUNX3, KLF6, CIITA, KLF8, PPARG2IRF1, KLF6
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
ERBB2IRF1No4CBL, STAT1, HSP90AA1, STUB1
ERBB2PIK3CANo14IL13RA2, IRS4, CRK, CBL, IRS1, PIK3R3, THRSP, PIK3R1, ERBB3, PIK3R2, ESR1, PSMC3IP, GRB2, STAT1
ERBB2APCNo10ERBB2IP, NAT2, PTK2, CYP17A1, JUP, XPO1, CTNNB1, PPP1R13B, AP2B1, MUC1
ERBB2FGFR2No7PLCG1, ERRFI1, GLCE, STAT3, PIK3R1, RHOBTB2, CBL
ERBB2KRASNo2THRSP, PIK3R2
MUTYHAPCNo1PCNA
IRF1PIK3CANo2CBL, STAT1
IRF1CASP10No1BIRC3
IRF1APCNo1CREBBP
IRF1FGFR2No1CBL
PIK3CACASP10No2TNFRSF1A, FASLG
PIK3CAAPCNo1IL24
PIK3CAFGFR2No4CBL, PIK3R1, BEX1, BEX2
PIK3CAKRASYes4THRSP, TNFSF13, IL24, PIK3R2
CASP10APCNo1TRAF1
KLF6FGFR2No1APP
KLF6KRASNo1APP
APCFGFR2No4HGS, PDLIM2, HOXC6, TFF1
APCKRASNo5NUP107, DIRAS3, BTRC, IL24, CCL5
FGFR2KRASNo1APP

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
ERBB2MUTYHNo-1UBC
ERBB2IRF1No-10PTGS2, STAT3, MAPK8, CCND1, MMP9, TP53, CD44, EGFR, UBC, STUB1
ERBB2PIK3CAYesactivation, binding57BCL2L1, EGFR, FIGF, TP53, RAC1, JAK2, SHC1, CTNND1, PIK3R2, PGF, PGR, PDGFB, GRB2, HGF, ITGA6, PTPN1, MAP2K1, JAK1, PTK2, ERBB3, CTNNB1, SOS1, VEGFC, PIK3CG, PDGFA, ESR1, ANGPT2, AR, HRAS, EFNB1, NOTCH1, CDH1, PLCG2, PIK3CB, RHOG, PIK3R3, RHOA, SRC, CBLB, MYC, STAT3, KRAS, PTPN11, IGF1R, CBLC, CBL, INS, PIK3R1, ERBB4, IGF1, EGF, PLCG1, PIK3CD, CCND1, VEGFA, PIK3R5, RAC3
ERBB2KLF6No-3UBC, CCND1, CDH1
ERBB2FGFR2No-37PLCG1, PIK3CG, FIGF, SHC2, PGF, ANGPT2, PDGFB, SHC4, PIK3R5, PIK3CA, SOS1, VEGFC, SHC1, PGR, PDGFA, HGF, HRAS, UBC, PIK3CB, GRB2, PIK3R3, CBLB, VEGFB, RNF41, STAT3, TGFA, CBL, VEGFA, SHC3, CBLC, INS, PIK3R1, IGF1, EGF, PIK3CD, PDGFC, PDGFD
ERBB2KRASYesactivation, binding29BCL2L1, EGFR, PTPN11, TP53, SHC2, PTK2, PIK3CG, HBEGF, CCND1, SOS1, ERBB3, SHC1, SLC3A2, HRAS, HSP90AA1, UBC, SHC3, IL8, SRC, VEGFA, GRB2, NOTCH1, PIK3CB, SPRY2, PIK3CA, EGF, PIK3CD, MAP2K1, ERBB4
MUTYHIRF1No-2UBC, PCNA
MUTYHKLF6No-1UBC
MUTYHFGFR2No-1UBC
MUTYHKRASNo-1UBC
IRF1PIK3CANo-8STAT3, IL4, NR3C1, CCND1, RELA, IFNG, TP53, EGFR
IRF1KLF6No-5KAT2B, UBC, CCND1, JUN, CDKN1A
IRF1FGFR2No-7STAT3, MDM2, SMARCB1, STAT5B, STAT5A, UBC, NCAM1
IRF1KRASNo-7CCND1, TP53, JUN, NPM1, EGFR, UBC, NCAM1
PIK3CAKLF6No-5SP1, CCND1, CDH1, RPS6KB1, KDR
PIK3CAFGFR2Yesactivation, binding34PLCG1, PGF, FIGF, IRS1, PIK3CG, PDGFB, ANGPT2, CRKL, ANGPT1, KITLG, CRK, PIK3R5, SOS1, VEGFC, SHC1, PGR, PDGFA, HGF, HRAS, PIK3CB, GRB2, PIK3R3, CBLB, PIK3CD, STAT3, CBL, EFNA1, CBLC, INS, PIK3R1, IGF1, EGF, FRS2, VEGFA
PIK3CAKRASYesactivation, binding37BCL2L1, EGFR, RET, MAP2K2, TP53, SOS1, PIK3CG, TEK, VEGFA, ANGPT1, MAP2K1, PTK2, EPHA2, ERBB2, ERBB3, RAF1, SHC1, AKT2, KIT, HRAS, RPS6KB1, GRB2, AKT1, SRC, FYN, FRS2, YES1, NOTCH1, PTPN11, PIK3CB, MTOR, IRS2, EGF, IRS1, PIK3CD, CCND1, ERBB4
KLF6FGFR2No-1UBC
KLF6KRASNo-4UBC, CCND1, JUN, RPS6KB1
FGFR2KRASNo-17ANGPT1, VEGFA, FRS2, HRAS, PIK3CB, SHC2, EGF, SHC3, PIK3CA, PIK3CG, SOS1, UBC, IRS1, SHC1, NCAM1, PIK3CD, GRB2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Pathways in cancerhsa052003.985APC, ERBB2, FGFR2, KRAS, PIK3CA
Signaling pathways regulating pluripotency of stem cellshsa045505.64APC, FGFR2, KRAS, PIK3CA
Endometrial cancerhsa052136.814APC, ERBB2, KRAS, PIK3CA
MicroRNAs in cancerhsa052065.384APC, ERBB2, KRAS, PIK3CA
Prostate cancerhsa052156.114ERBB2, KRAS, FGFR2, PIK3CA
Central carbon metabolism in cancerhsa052306.74ERBB2, KRAS, FGFR2, PIK3CA
Regulation of actin cytoskeletonhsa048104.94APC, FGFR2, KRAS, PIK3CA
Pancreatic cancerhsa052126.563ERBB2, KRAS, PIK3CA
Colorectal cancerhsa052106.523APC, KRAS, PIK3CA
Prolactin signaling pathwayhsa049176.63IRF1, KRAS, PIK3CA
Proteoglycans in cancerhsa052055.023ERBB2, KRAS, PIK3CA
Rap1 signaling pathwayhsa040154.973KRAS, FGFR2, PIK3CA
Ras signaling pathwayhsa040144.93KRAS, FGFR2, PIK3CA
Non-small cell lung cancerhsa052236.883ERBB2, KRAS, PIK3CA
ErbB signaling pathwayhsa040126.153ERBB2, KRAS, PIK3CA
HTLV-I infectionhsa051664.593APC, KRAS, PIK3CA
Hepatitis Chsa051605.683IRF1, KRAS, PIK3CA
Hepatitis Bhsa051615.523KRAS, PIK3CA, CASP10
PI3K-Akt signaling pathwayhsa041514.213KRAS, FGFR2, PIK3CA
Melanomahsa052186.562KRAS, PIK3CA
Bladder cancerhsa052197.382ERBB2, KRAS
Progesterone-mediated oocyte maturationhsa049146.182KRAS, PIK3CA
Natural killer cell mediated cytotoxicityhsa046505.532KRAS, PIK3CA
MAPK signaling pathwayhsa040104.632KRAS, FGFR2
Gliomahsa052146.662KRAS, PIK3CA
Neurotrophin signaling pathwayhsa047225.782KRAS, PIK3CA
Cholinergic synapsehsa047255.882KRAS, PIK3CA
Choline metabolism in cancerhsa052316.092KRAS, PIK3CA
FoxO signaling pathwayhsa040685.632KRAS, PIK3CA
HIF-1 signaling pathwayhsa040665.92ERBB2, PIK3CA
Chemokine signaling pathwayhsa040625.192KRAS, PIK3CA
Oxytocin signaling pathwayhsa049215.42KRAS, PIK3CA
Aldosterone-regulated sodium reabsorptionhsa049607.412KRAS, PIK3CA
Focal adhesionhsa045104.922ERBB2, PIK3CA
Apoptosishsa042106.232PIK3CA, CASP10
Renal cell carcinomahsa052116.62KRAS, PIK3CA
VEGF signaling pathwayhsa043706.772KRAS, PIK3CA
Estrogen signaling pathwayhsa049156.112KRAS, PIK3CA
Viral carcinogenesishsa052035.082KRAS, PIK3CA
T cell receptor signaling pathwayhsa046606.012KRAS, PIK3CA
B cell receptor signaling pathwayhsa046626.522KRAS, PIK3CA
Fc epsilon RI signaling pathwayhsa046646.62KRAS, PIK3CA
Acute myeloid leukemiahsa052216.742KRAS, PIK3CA
Chronic myeloid leukemiahsa052206.482KRAS, PIK3CA
TNF signaling pathwayhsa046685.962PIK3CA, CASP10
Thyroid hormone signaling pathwayhsa049195.822KRAS, PIK3CA
Insulin signaling pathwayhsa049105.552KRAS, PIK3CA

NET-GE enrichment

Term New enriched termICP valueGenes
Melanoma (hsa05218) -6.560.001ERBB2, KRAS, FGFR2, PIK3CA
Pancreatic cancer (hsa05212) -6.560.008ERBB2, KRAS, PIK3CA
Endometrial cancer (hsa05213) -6.810.0APC, ERBB2, KRAS, PIK3CA
Colorectal cancer (hsa05210) -6.520.027APC, KRAS, PIK3CA
Signaling pathways regulating pluripotency of stem cells (hsa04550) -5.60.001APC, FGFR2, KRAS, PIK3CA
Glioma (hsa05214) -6.660.018ERBB2, KRAS, PIK3CA
Prostate cancer (hsa05215) -6.110.0ERBB2, KRAS, FGFR2, PIK3CA
Central carbon metabolism in cancer (hsa05230) -6.70.0ERBB2, KRAS, FGFR2, PIK3CA
FoxO signaling pathway (hsa04068) -5.630.033ERBB2, KRAS, PIK3CA, CASP10
Cellular communityNEW3.570.023APC, ERBB2, FGFR2, KRAS, PIK3CA
HTLV-I infection (hsa05166) -4.590.039APC, IRF1, FGFR2, KRAS, PIK3CA
Hepatitis C (hsa05160) -5.680.046IRF1, KRAS, PIK3CA
Hepatitis B (hsa05161) -5.520.013IRF1, KRAS, PIK3CA, CASP10
Cancers: Specific typesNEW4.10.004APC, ERBB2, KRAS, FGFR2, PIK3CA
Infectious diseases: BacterialNEW3.760.005APC, CASP10, FGFR2, IRF1, PIK3CA, ERBB2, KRAS
Infectious diseases: ViralNEW3.290.048APC, CASP10, FGFR2, IRF1, PIK3CA, ERBB2, KRAS
MicroRNAs in cancer (hsa05206) -5.380.003APC, ERBB2, KRAS, PIK3CA
Pathways in cancer (hsa05200) -3.980.006APC, ERBB2, FGFR2, KRAS, PIK3CA
Non-small cell lung cancer (hsa05223) -6.880.021ERBB2, KRAS, PIK3CA
ErbB signaling pathway (hsa04012) -6.150.017ERBB2, KRAS, PIK3CA
Chronic myeloid leukemia (hsa05220) -6.480.03ERBB2, KRAS, PIK3CA
Cell motilityNEW4.90.009APC, ERBB2, FGFR2, KRAS, PIK3CA
Regulation of actin cytoskeleton (hsa04810) -4.90.009APC, ERBB2, FGFR2, KRAS, PIK3CA
Tuberculosis (hsa05152) NEW5.170.005IRF1, KRAS, PIK3CA, CASP10, ERBB2
Prolactin signaling pathway (hsa04917) -6.60.007ERBB2, KRAS, IRF1, PIK3CA
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Innate Immune SystemR-HSA-1682493.176CASP10, FGFR2, IRF1, KRAS, ERBB2, PIK3CA
Immune SystemR-HSA-1682562.376CASP10, FGFR2, IRF1, KRAS, ERBB2, PIK3CA
Signal TransductionR-HSA-1625821.786APC, CASP10, FGFR2, KRAS, ERBB2, PIK3CA
Cytokine Signaling in Immune systemR-HSA-12802153.745ERBB2, KRAS, FGFR2, IRF1, PIK3CA
DiseaseR-HSA-16436853.335APC, ERBB2, FGFR2, KRAS, PIK3CA
Diseases of signal transductionR-HSA-56632024.895APC, ERBB2, KRAS, FGFR2, PIK3CA
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.854ERBB2, KRAS, FGFR2, PIK3CA
Signaling by InterleukinsR-HSA-4491474.714ERBB2, KRAS, FGFR2, PIK3CA
Interleukin-2 signalingR-HSA-4519275.054ERBB2, KRAS, FGFR2, PIK3CA
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.624ERBB2, KRAS, FGFR2, PIK3CA
IGF1R signaling cascadeR-HSA-24289244.854ERBB2, KRAS, FGFR2, PIK3CA
Downstream signal transductionR-HSA-1867634.654ERBB2, KRAS, FGFR2, PIK3CA
IRS-related events triggered by IGF1RR-HSA-24289284.854ERBB2, KRAS, FGFR2, PIK3CA
Signaling by ERBB4R-HSA-12363944.74ERBB2, KRAS, FGFR2, PIK3CA
Signaling by Insulin receptorR-HSA-747524.734ERBB2, KRAS, FGFR2, PIK3CA
Adaptive Immune SystemR-HSA-12802183.194ERBB2, KRAS, FGFR2, PIK3CA
Insulin receptor signalling cascadeR-HSA-747514.854ERBB2, KRAS, FGFR2, PIK3CA
Downstream signaling of activated FGFR1R-HSA-56546874.714ERBB2, KRAS, FGFR2, PIK3CA
Signalling by NGFR-HSA-1665204.234ERBB2, KRAS, FGFR2, PIK3CA
Signaling by VEGFR-HSA-1941384.664ERBB2, KRAS, FGFR2, PIK3CA
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.264ERBB2, KRAS, FGFR2, PIK3CA
IRS-mediated signallingR-HSA-1123994.874ERBB2, KRAS, FGFR2, PIK3CA
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.594ERBB2, KRAS, FGFR2, PIK3CA
Downstream signaling of activated FGFR3R-HSA-56547084.714ERBB2, KRAS, FGFR2, PIK3CA
Signaling by FGFR4R-HSA-56547434.694ERBB2, KRAS, FGFR2, PIK3CA
Signaling by FGFR3R-HSA-56547414.694ERBB2, KRAS, FGFR2, PIK3CA
VEGFA-VEGFR2 PathwayR-HSA-44200974.74ERBB2, KRAS, FGFR2, PIK3CA
Signaling by FGFRR-HSA-1902364.674ERBB2, KRAS, FGFR2, PIK3CA
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.034ERBB2, KRAS, FGFR2, PIK3CA
Interleukin receptor SHC signalingR-HSA-9125265.094ERBB2, KRAS, FGFR2, PIK3CA
Signaling by SCF-KITR-HSA-14335574.734ERBB2, KRAS, FGFR2, PIK3CA
Signaling by PDGFR-HSA-1867974.534ERBB2, KRAS, FGFR2, PIK3CA
DAP12 signalingR-HSA-24244914.644ERBB2, KRAS, FGFR2, PIK3CA
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.994ERBB2, KRAS, FGFR2, PIK3CA
Downstream signaling of activated FGFR2R-HSA-56546964.714ERBB2, KRAS, FGFR2, PIK3CA
Signaling by EGFRR-HSA-1779294.594ERBB2, KRAS, FGFR2, PIK3CA
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.514ERBB2, KRAS, FGFR2, PIK3CA
Signaling by GPCRR-HSA-3727902.684ERBB2, KRAS, FGFR2, PIK3CA
Signaling by FGFR2R-HSA-56547384.684ERBB2, KRAS, FGFR2, PIK3CA
Signaling by FGFR1R-HSA-56547364.694ERBB2, KRAS, FGFR2, PIK3CA
DAP12 interactionsR-HSA-21721274.564ERBB2, KRAS, FGFR2, PIK3CA
Downstream signaling of activated FGFR4R-HSA-56547164.714ERBB2, KRAS, FGFR2, PIK3CA
Signaling by ERBB2R-HSA-12279864.664ERBB2, KRAS, FGFR2, PIK3CA
PI3K/AKT activationR-HSA-1982036.323ERBB2, FGFR2, PIK3CA
Signaling by LeptinR-HSA-25865525.13ERBB2, KRAS, FGFR2
Frs2-mediated activationR-HSA-1709685.123ERBB2, KRAS, FGFR2
PI3K events in ERBB2 signalingR-HSA-19636426.373ERBB2, FGFR2, PIK3CA
GAB1 signalosomeR-HSA-1802926.313ERBB2, FGFR2, PIK3CA
MAPK1/MAPK3 signalingR-HSA-56849965.113ERBB2, KRAS, FGFR2
Developmental BiologyR-HSA-12667383.483ERBB2, KRAS, FGFR2
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.953ERBB2, FGFR2, PIK3CA
MAPK family signaling cascadesR-HSA-56830574.893ERBB2, KRAS, FGFR2
PIP3 activates AKT signalingR-HSA-12576046.373ERBB2, FGFR2, PIK3CA
PI-3K cascade:FGFR4R-HSA-56547206.373ERBB2, FGFR2, PIK3CA
Signalling to p38 via RIT and RINR-HSA-1877065.123ERBB2, KRAS, FGFR2
PI-3K cascade:FGFR1R-HSA-56546896.373ERBB2, FGFR2, PIK3CA
FCERI mediated MAPK activationR-HSA-28717964.323ERBB2, KRAS, FGFR2
FRS-mediated FGFR2 signalingR-HSA-56547005.143ERBB2, KRAS, FGFR2
SOS-mediated signallingR-HSA-1124125.153ERBB2, KRAS, FGFR2
FRS-mediated FGFR3 signalingR-HSA-56547065.143ERBB2, KRAS, FGFR2
RAF/MAP kinase cascadeR-HSA-56730015.153ERBB2, KRAS, FGFR2
Signaling by FGFR in diseaseR-HSA-12260997.493KRAS, FGFR2, PIK3CA
PI3K/AKT Signaling in CancerR-HSA-22195286.563ERBB2, FGFR2, PIK3CA
GRB2 events in ERBB2 signalingR-HSA-19636405.153ERBB2, KRAS, FGFR2
SHC1 events in ERBB4 signalingR-HSA-12503475.153ERBB2, KRAS, FGFR2
Constitutive Signaling by Aberrant PI3K in CancerR-HSA-22195307.053ERBB2, FGFR2, PIK3CA
NCAM signaling for neurite out-growthR-HSA-3751654.93ERBB2, KRAS, FGFR2
Signalling to RASR-HSA-1670445.083ERBB2, KRAS, FGFR2
PI-3K cascade:FGFR2R-HSA-56546956.373ERBB2, FGFR2, PIK3CA
SHC1 events in EGFR signalingR-HSA-1803365.153ERBB2, KRAS, FGFR2
FRS-mediated FGFR1 signalingR-HSA-56546935.143ERBB2, KRAS, FGFR2
Prolonged ERK activation eventsR-HSA-1698935.113ERBB2, KRAS, FGFR2
GRB2 events in EGFR signalingR-HSA-1798125.153ERBB2, KRAS, FGFR2
Signalling to ERKsR-HSA-1876875.043ERBB2, KRAS, FGFR2
PI3K events in ERBB4 signalingR-HSA-12503426.373ERBB2, FGFR2, PIK3CA
ARMS-mediated activationR-HSA-1709845.123ERBB2, KRAS, FGFR2
PI-3K cascade:FGFR3R-HSA-56547106.373ERBB2, FGFR2, PIK3CA
FRS-mediated FGFR4 signalingR-HSA-56547125.143ERBB2, KRAS, FGFR2
SHC1 events in ERBB2 signalingR-HSA-12501965.153ERBB2, KRAS, FGFR2
Axon guidanceR-HSA-4224753.933ERBB2, KRAS, FGFR2
VEGFR2 mediated cell proliferationR-HSA-52189215.073ERBB2, KRAS, FGFR2
Signaling by FGFR2 in diseaseR-HSA-56552538.233KRAS, FGFR2, PIK3CA
HemostasisR-HSA-1095823.983IRF1, KRAS, PIK3CA
Signaling by FGFR3 in diseaseR-HSA-56553328.522KRAS, PIK3CA
Signaling by FGFR1 in diseaseR-HSA-56553027.812KRAS, PIK3CA
Signaling by Ligand-Responsive EGFR Variants in CancerR-HSA-56378158.732KRAS, PIK3CA
PI3K CascadeR-HSA-1097046.682FGFR2, PIK3CA
Signaling by FGFR4 in diseaseR-HSA-56552919.522KRAS, PIK3CA
Tie2 SignalingR-HSA-2109938.812KRAS, PIK3CA
Constitutive Signaling by EGFRvIIIR-HSA-56378109.082KRAS, PIK3CA
Signaling by EGFRvIII in CancerR-HSA-56378129.082KRAS, PIK3CA
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysR-HSA-1689286.72IRF1, CASP10
Signaling by EGFR in CancerR-HSA-16437138.732KRAS, PIK3CA
Cell surface interactions at the vascular wallR-HSA-2027336.322KRAS, PIK3CA
Constitutive Signaling by Ligand-Responsive EGFR Cancer VariantsR-HSA-12363828.732KRAS, PIK3CA
SHC-mediated cascade:FGFR2R-HSA-56546998.282KRAS, FGFR2

NET-GE enrichment

Term New enriched termICP valueGenes
Downstream signaling events of B Cell Receptor (BCR) (R-HSA-1168372) -5.590.002ERBB2, KRAS, FGFR2, PIK3CA
PI3K/AKT activation (R-HSA-198203) -6.320.019ERBB2, FGFR2, PIK3CA
Signaling by FGFR3 in disease (R-HSA-5655332) -8.520.037KRAS, PIK3CA
Signaling by Interleukins (R-HSA-449147) -4.710.016APC, ERBB2, FGFR2, KRAS, PIK3CA
Interleukin-2 signaling (R-HSA-451927) -5.050.01ERBB2, KRAS, FGFR2, PIK3CA
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530) -7.050.004ERBB2, FGFR2, PIK3CA
Signaling by the B Cell Receptor (BCR) (R-HSA-983705) -4.620.031ERBB2, KRAS, FGFR2, PIK3CA
Cytokine Signaling in Immune system (R-HSA-1280215) -3.740.02APC, FGFR2, IRF1, KRAS, ERBB2, PIK3CA
IGF1R signaling cascade (R-HSA-2428924) -4.850.017ERBB2, KRAS, FGFR2, PIK3CA
Downstream signal transduction (R-HSA-186763) -4.650.024APC, ERBB2, FGFR2, KRAS, PIK3CA
GAB1 signalosome (R-HSA-180292) -6.310.02ERBB2, FGFR2, PIK3CA
Signaling by EGFR in Cancer (R-HSA-1643713) -8.730.027KRAS, PIK3CA
IRS-related events triggered by IGF1R (R-HSA-2428928) -4.850.017ERBB2, KRAS, FGFR2, PIK3CA
Signaling by ERBB4 (R-HSA-1236394) -4.70.025ERBB2, KRAS, FGFR2, PIK3CA
Signaling by Insulin receptor (R-HSA-74752) -4.730.023ERBB2, KRAS, FGFR2, PIK3CA
Insulin receptor signalling cascade (R-HSA-74751) -4.850.017ERBB2, KRAS, FGFR2, PIK3CA
Downstream signaling of activated FGFR1 (R-HSA-5654687) -4.710.025ERBB2, KRAS, FGFR2, PIK3CA
PIP3 activates AKT signaling (R-HSA-1257604) -6.370.017ERBB2, FGFR2, PIK3CA
Signaling by VEGF (R-HSA-194138) -4.660.021APC, ERBB2, KRAS, PIK3CA, FGFR2
PI-3K cascade:FGFR1 (R-HSA-5654689) -6.370.017ERBB2, FGFR2, PIK3CA
IRS-mediated signalling (R-HSA-112399) -4.870.016ERBB2, KRAS, FGFR2, PIK3CA
Signaling by Ligand-Responsive EGFR Variants in Cancer (R-HSA-5637815) -8.730.027KRAS, PIK3CA
Constitutive Signaling by EGFRvIII (R-HSA-5637810) -9.080.017KRAS, PIK3CA
Signaling by EGFRvIII in Cancer (R-HSA-5637812) -9.080.017KRAS, PIK3CA
Downstream signaling of activated FGFR3 (R-HSA-5654708) -4.710.025ERBB2, KRAS, FGFR2, PIK3CA
Signaling by FGFR4 (R-HSA-5654743) -4.690.026ERBB2, KRAS, FGFR2, PIK3CA
Signaling by FGFR in disease (R-HSA-1226099) -7.490.007KRAS, FGFR2, PIK3CA
Signaling by FGFR3 (R-HSA-5654741) -4.690.026ERBB2, KRAS, FGFR2, PIK3CA
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (R-HSA-2404192) -4.850.017ERBB2, KRAS, FGFR2, PIK3CA
VEGFA-VEGFR2 Pathway (R-HSA-4420097) -4.70.017APC, ERBB2, FGFR2, KRAS, PIK3CA
Signaling by FGFR (R-HSA-190236) -4.670.027ERBB2, KRAS, FGFR2, PIK3CA
PI3K/AKT Signaling in Cancer (R-HSA-2219528) -6.560.012ERBB2, FGFR2, PIK3CA
Diseases of signal transduction (R-HSA-5663202) -4.890.0APC, ERBB2, KRAS, FGFR2, PIK3CA
Interleukin receptor SHC signaling (R-HSA-912526) -5.090.009ERBB2, KRAS, FGFR2, PIK3CA
Innate Immune System (R-HSA-168249) -3.170.021APC, CASP10, FGFR2, IRF1, PIK3CA, ERBB2, KRAS
Signaling by SCF-KIT (R-HSA-1433557) -4.730.024ERBB2, KRAS, FGFR2, PIK3CA
PI-3K cascade:FGFR4 (R-HSA-5654720) -6.370.017ERBB2, FGFR2, PIK3CA
Signaling by PDGF (R-HSA-186797) -4.530.04APC, ERBB2, FGFR2, KRAS, PIK3CA
DAP12 signaling (R-HSA-2424491) -4.640.03ERBB2, KRAS, FGFR2, PIK3CA
Interleukin-3, 5 and GM-CSF signaling (R-HSA-512988) -4.990.011APC, ERBB2, FGFR2, KRAS, PIK3CA
PI-3K cascade:FGFR2 (R-HSA-5654695) -6.370.017ERBB2, FGFR2, PIK3CA
Downstream signaling of activated FGFR2 (R-HSA-5654696) -4.710.025ERBB2, KRAS, FGFR2, PIK3CA
Signaling by FGFR1 in disease (R-HSA-5655302) -7.810.004KRAS, FGFR2, PIK3CA
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (R-HSA-1236382) -8.730.027KRAS, PIK3CA
Signaling by EGFR (R-HSA-177929) -4.590.033ERBB2, KRAS, FGFR2, PIK3CA
NGF signalling via TRKA from the plasma membrane (R-HSA-187037) -4.510.042APC, ERBB2, KRAS, PIK3CA, FGFR2
Prolonged ERK activation events (R-HSA-169893) -5.110.004APC, ERBB2, FGFR2, KRAS, PIK3CA
Signalling to ERKs (R-HSA-187687) -5.040.005APC, ERBB2, FGFR2, KRAS, PIK3CA
Signaling by FGFR2 (R-HSA-5654738) -4.680.027ERBB2, KRAS, FGFR2, PIK3CA
Signaling by FGFR1 (R-HSA-5654736) -4.690.026ERBB2, KRAS, FGFR2, PIK3CA
PI3K events in ERBB4 signaling (R-HSA-1250342) -6.370.017ERBB2, FGFR2, PIK3CA
ARMS-mediated activation (R-HSA-170984) -5.120.003APC, ERBB2, FGFR2, KRAS, PIK3CA
PI-3K cascade:FGFR3 (R-HSA-5654710) -6.370.017ERBB2, FGFR2, PIK3CA
Signaling by FGFR4 in disease (R-HSA-5655291) -9.520.009KRAS, PIK3CA
DAP12 interactions (R-HSA-2172127) -4.560.036ERBB2, KRAS, FGFR2, PIK3CA
Tie2 Signaling (R-HSA-210993) -8.810.025KRAS, PIK3CA
Downstream signaling of activated FGFR4 (R-HSA-5654716) -4.710.025ERBB2, KRAS, FGFR2, PIK3CA
Signaling by ERBB2 (R-HSA-1227986) -4.660.028ERBB2, KRAS, FGFR2, PIK3CA
Signaling by FGFR2 in disease (R-HSA-5655253) -8.230.0KRAS, FGFR2, PIK3CA
Hemostasis (R-HSA-109582) -3.980.041APC, FGFR2, IRF1, KRAS, ERBB2, PIK3CA
PI3K events in ERBB2 signaling (R-HSA-1963642) -6.370.017ERBB2, FGFR2, PIK3CA
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.189APC, FGFR2, CASP10, IRF1, PIK3CA, ERBB2, KRAS, KLF6, MUTYH
protein binding (GO:0005515) 0.469APC, FGFR2, CASP10, MUTYH, PIK3CA, ERBB2, KRAS, KLF6, IRF1
organic cyclic compound binding (GO:0097159) 1.057FGFR2, MUTYH, PIK3CA, ERBB2, KRAS, KLF6, IRF1
heterocyclic compound binding (GO:1901363) 1.067FGFR2, MUTYH, PIK3CA, ERBB2, KRAS, KLF6, IRF1
catalytic activity (GO:0003824) 1.056CASP10, FGFR2, MUTYH, KRAS, ERBB2, PIK3CA
carbohydrate derivative binding (GO:0097367) 2.034ERBB2, KRAS, FGFR2, PIK3CA
nucleotide binding (GO:0000166) 1.964ERBB2, KRAS, FGFR2, PIK3CA
small molecule binding (GO:0036094) 1.894ERBB2, KRAS, FGFR2, PIK3CA
purine ribonucleoside triphosphate binding (GO:0035639) 2.224ERBB2, KRAS, FGFR2, PIK3CA
ribonucleotide binding (GO:0032553) 2.194ERBB2, KRAS, FGFR2, PIK3CA
purine nucleoside binding (GO:0001883) 2.224ERBB2, KRAS, FGFR2, PIK3CA
ribonucleoside binding (GO:0032549) 2.224ERBB2, KRAS, FGFR2, PIK3CA
purine ribonucleotide binding (GO:0032555) 2.24ERBB2, KRAS, FGFR2, PIK3CA
purine nucleotide binding (GO:0017076) 2.194ERBB2, KRAS, FGFR2, PIK3CA
molecular function regulator (GO:0098772) 2.514APC, ERBB2, PIK3CA, FGFR2
purine ribonucleoside binding (GO:0032550) 2.224ERBB2, KRAS, FGFR2, PIK3CA
nucleoside phosphate binding (GO:1901265) 1.964ERBB2, KRAS, FGFR2, PIK3CA
nucleoside binding (GO:0001882) 2.214ERBB2, KRAS, FGFR2, PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934) 5.613ERBB2, FGFR2, PIK3CA
cation binding (GO:0043169) 1.43MUTYH, KRAS, KLF6
adenyl nucleotide binding (GO:0030554) 2.43ERBB2, FGFR2, PIK3CA
signal transducer activity (GO:0004871) 2.283ERBB2, FGFR2, CASP10
hydrolase activity (GO:0016787) 1.93MUTYH, KRAS, CASP10
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.083ERBB2, FGFR2, PIK3CA
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.773ERBB2, FGFR2, PIK3CA
kinase activity (GO:0016301) 2.933ERBB2, FGFR2, PIK3CA
enzyme binding (GO:0019899) 2.273APC, ERBB2, CASP10
ion binding (GO:0043167) 1.363MUTYH, KRAS, KLF6
phosphatidylinositol bisphosphate kinase activity (GO:0052813) 5.563ERBB2, FGFR2, PIK3CA
transferase activity (GO:0016740) 1.953ERBB2, FGFR2, PIK3CA
macromolecular complex binding (GO:0044877) 2.613APC, MUTYH, KRAS
protein kinase activity (GO:0004672) 3.273ERBB2, FGFR2, PIK3CA
phosphatidylinositol 3-kinase activity (GO:0035004) 5.493ERBB2, FGFR2, PIK3CA
DNA binding (GO:0003677) 1.923MUTYH, IRF1, KLF6
protein complex binding (GO:0032403) 3.093APC, MUTYH, KRAS
adenyl ribonucleotide binding (GO:0032559) 2.413ERBB2, FGFR2, PIK3CA
nucleic acid binding (GO:0003676) 1.443MUTYH, IRF1, KLF6
metal ion binding (GO:0046872) 1.413MUTYH, KRAS, KLF6
ATP binding (GO:0005524) 2.433ERBB2, FGFR2, PIK3CA
Ras guanyl-nucleotide exchange factor activity (GO:0005088) 4.312ERBB2, FGFR2
signaling receptor activity (GO:0038023) 2.492ERBB2, FGFR2
kinase regulator activity (GO:0019207) 4.52APC, PIK3CA
guanyl-nucleotide exchange factor activity (GO:0005085) 4.022ERBB2, FGFR2
molecular transducer activity (GO:0060089) 2.322ERBB2, FGFR2
nucleic acid binding transcription factor activity (GO:0001071) 2.652IRF1, KLF6
growth factor binding (GO:0019838) 4.892ERBB2, FGFR2
transmembrane receptor protein tyrosine kinase activity (GO:0004714) 5.552ERBB2, FGFR2
protein tyrosine kinase activity (GO:0004713) 4.542ERBB2, FGFR2
double-stranded DNA binding (GO:0003690) 3.092IRF1, KLF6
identical protein binding (GO:0042802) 2.632ERBB2, FGFR2
protein kinase regulator activity (GO:0019887) 4.62APC, PIK3CA
1-phosphatidylinositol-3-kinase activity (GO:0016303) 5.982FGFR2, PIK3CA
enzyme regulator activity (GO:0030234) 2.852APC, PIK3CA
protein domain specific binding (GO:0019904) 3.322KRAS, CASP10
phosphatidylinositol kinase activity (GO:0052742) 5.812FGFR2, PIK3CA
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.652IRF1, KLF6
transmembrane signaling receptor activity (GO:0004888) 2.572ERBB2, FGFR2
protein dimerization activity (GO:0046983) 2.722ERBB2, FGFR2
transmembrane receptor protein kinase activity (GO:0019199) 5.322ERBB2, FGFR2
transmembrane receptor activity (GO:0099600) 2.532ERBB2, FGFR2
receptor activity (GO:0004872) 2.322ERBB2, FGFR2

NET-GE enrichment

Term New enriched termICP valueGenes
cytokine receptor binding (GO:0005126) NEW4.140.002ERBB2, KRAS, FGFR2, IRF1, PIK3CA
sequence-specific DNA binding (GO:0043565) NEW2.790.031APC, FGFR2, IRF1, KRAS, ERBB2, PIK3CA
receptor signaling protein activity (GO:0005057) NEW4.760.004ERBB2, FGFR2, IRF1, PIK3CA
GTPase activator activity (GO:0005096) NEW4.110.046APC, ERBB2, KRAS, PIK3CA
transmembrane receptor protein tyrosine kinase activity (GO:0004714) -5.550.011ERBB2, KRAS, FGFR2
calcium ion binding (GO:0005509) NEW3.170.003APC, FGFR2, IRF1, PIK3CA, ERBB2, KRAS, KLF6
protein complex binding (GO:0032403) -3.090.008APC, FGFR2, MUTYH, PIK3CA, ERBB2, KRAS, IRF1
binding, bridging (GO:0060090) NEW4.570.013ERBB2, KRAS, FGFR2, PIK3CA
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
macromolecule metabolic process (GO:0043170) 0.839APC, FGFR2, CASP10, IRF1, PIK3CA, ERBB2, KRAS, KLF6, MUTYH
organic substance metabolic process (GO:0071704) 0.639APC, FGFR2, CASP10, IRF1, PIK3CA, ERBB2, KRAS, KLF6, MUTYH
cellular process (GO:0009987) 0.269APC, FGFR2, CASP10, IRF1, PIK3CA, ERBB2, KRAS, KLF6, MUTYH
metabolic process (GO:0008152) 0.589APC, FGFR2, CASP10, MUTYH, PIK3CA, ERBB2, KRAS, KLF6, IRF1
primary metabolic process (GO:0044238) 0.699APC, FGFR2, CASP10, MUTYH, PIK3CA, ERBB2, KRAS, KLF6, IRF1
cellular macromolecule metabolic process (GO:0044260) 0.938APC, FGFR2, MUTYH, PIK3CA, ERBB2, KRAS, KLF6, IRF1
cellular metabolic process (GO:0044237) 0.698APC, FGFR2, MUTYH, PIK3CA, ERBB2, KRAS, KLF6, IRF1
regulation of cellular process (GO:0050794) 0.58APC, FGFR2, CASP10, IRF1, PIK3CA, ERBB2, KRAS, KLF6
single-organism cellular process (GO:0044763) 0.658APC, FGFR2, CASP10, IRF1, PIK3CA, ERBB2, KRAS, KLF6
positive regulation of biological process (GO:0048518) 1.28APC, FGFR2, CASP10, IRF1, PIK3CA, ERBB2, KRAS, KLF6
biological regulation (GO:0065007) 0.398APC, FGFR2, CASP10, IRF1, PIK3CA, ERBB2, KRAS, KLF6
regulation of biological process (GO:0050789) 0.458APC, FGFR2, CASP10, IRF1, PIK3CA, ERBB2, KRAS, KLF6
single-organism process (GO:0044699) 0.488APC, FGFR2, CASP10, IRF1, PIK3CA, ERBB2, KRAS, KLF6
positive regulation of cellular process (GO:0048522) 1.38APC, FGFR2, CASP10, IRF1, PIK3CA, ERBB2, KRAS, KLF6
positive regulation of metabolic process (GO:0009893) 1.747APC, FGFR2, IRF1, PIK3CA, ERBB2, KRAS, KLF6
regulation of metabolic process (GO:0019222) 1.027APC, FGFR2, IRF1, PIK3CA, ERBB2, KRAS, KLF6
regulation of signal transduction (GO:0009966) 1.847APC, CASP10, FGFR2, IRF1, PIK3CA, ERBB2, KRAS
cellular developmental process (GO:0048869) 1.827APC, CASP10, FGFR2, IRF1, KRAS, ERBB2, KLF6
response to stimulus (GO:0050896) 1.227APC, MUTYH, PIK3CA, ERBB2, KRAS, KLF6, IRF1
regulation of response to stimulus (GO:0048583) 1.547APC, CASP10, FGFR2, IRF1, PIK3CA, ERBB2, KRAS
positive regulation of macromolecule metabolic process (GO:0010604) 1.817APC, FGFR2, IRF1, PIK3CA, ERBB2, KRAS, KLF6
regulation of cellular metabolic process (GO:0031323) 1.077APC, FGFR2, IRF1, PIK3CA, ERBB2, KRAS, KLF6
regulation of macromolecule metabolic process (GO:0060255) 1.087APC, FGFR2, IRF1, PIK3CA, ERBB2, KRAS, KLF6
signal transduction (GO:0007165) 1.287APC, CASP10, FGFR2, IRF1, PIK3CA, ERBB2, KRAS
cell surface receptor signaling pathway (GO:0007166) 2.097APC, CASP10, FGFR2, IRF1, PIK3CA, ERBB2, KRAS
regulation of signaling (GO:0023051) 1.727APC, CASP10, FGFR2, IRF1, PIK3CA, ERBB2, KRAS
regulation of cell communication (GO:0010646) 1.737APC, CASP10, FGFR2, IRF1, PIK3CA, ERBB2, KRAS
regulation of primary metabolic process (GO:0080090) 1.087APC, FGFR2, IRF1, PIK3CA, ERBB2, KRAS, KLF6
regulation of nitrogen compound metabolic process (GO:0051171) 1.367APC, FGFR2, IRF1, PIK3CA, ERBB2, KRAS, KLF6
cellular response to stimulus (GO:0051716) 1.976APC, MUTYH, PIK3CA, ERBB2, KLF6, IRF1
protein metabolic process (GO:0019538) 1.456APC, CASP10, FGFR2, KRAS, ERBB2, PIK3CA
positive regulation of cellular metabolic process (GO:0031325) 1.816FGFR2, IRF1, KRAS, ERBB2, PIK3CA, KLF6
cell differentiation (GO:0030154) 2.146CASP10, FGFR2, IRF1, KRAS, ERBB2, KLF6
regulation of protein metabolic process (GO:0051246) 1.936APC, FGFR2, IRF1, KRAS, ERBB2, PIK3CA
positive regulation of protein metabolic process (GO:0051247) 2.436APC, FGFR2, IRF1, KRAS, ERBB2, PIK3CA
regulation of gene expression (GO:0010468) 1.376FGFR2, IRF1, KRAS, ERBB2, PIK3CA, KLF6
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.436FGFR2, IRF1, KRAS, ERBB2, PIK3CA, KLF6
negative regulation of biological process (GO:0048519) 1.336APC, FGFR2, IRF1, KRAS, ERBB2, PIK3CA
response to chemical (GO:0042221) 1.986APC, IRF1, KRAS, ERBB2, PIK3CA, KLF6
response to organic substance (GO:0010033) 2.26APC, IRF1, KRAS, ERBB2, PIK3CA, KLF6
negative regulation of cellular process (GO:0048523) 1.416APC, FGFR2, IRF1, KRAS, ERBB2, PIK3CA
developmental process (GO:0032502) 1.365APC, ERBB2, KRAS, FGFR2, PIK3CA
anatomical structure development (GO:0048856) 1.585APC, ERBB2, FGFR2, KRAS, PIK3CA
regulation of phosphate metabolic process (GO:0019220) 2.355APC, ERBB2, FGFR2, KRAS, PIK3CA
regulation of cellular biosynthetic process (GO:0031326) 1.385ERBB2, KRAS, FGFR2, IRF1, KLF6
positive regulation of response to stimulus (GO:0048584) 2.185ERBB2, KRAS, FGFR2, PIK3CA, CASP10
cellular biosynthetic process (GO:0044249) 1.375ERBB2, FGFR2, IRF1, KLF6, PIK3CA
positive regulation of gene expression (GO:0010628) 2.355ERBB2, KRAS, FGFR2, IRF1, KLF6
cellular response to chemical stimulus (GO:0070887) 2.575APC, ERBB2, IRF1, KLF6, PIK3CA
regulation of cell differentiation (GO:0045595) 2.425APC, ERBB2, KRAS, IRF1, FGFR2
cellular component organization or biogenesis (GO:0071840) 1.225APC, ERBB2, KRAS, FGFR2, PIK3CA
organic substance biosynthetic process (GO:1901576) 1.345ERBB2, FGFR2, IRF1, KLF6, PIK3CA
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.465ERBB2, KRAS, FGFR2, IRF1, KLF6
cellular component organization (GO:0016043) 1.245APC, ERBB2, KRAS, FGFR2, PIK3CA
cellular response to organic substance (GO:0071310) 2.785APC, KLF6, ERBB2, IRF1, PIK3CA
regulation of protein modification process (GO:0031399) 2.325APC, ERBB2, KRAS, FGFR2, PIK3CA
regulation of molecular function (GO:0065009) 1.785APC, ERBB2, KRAS, PIK3CA, FGFR2
regulation of cell proliferation (GO:0042127) 2.415APC, ERBB2, KRAS, IRF1, FGFR2
multicellular organismal process (GO:0032501) 1.455APC, IRF1, KRAS, FGFR2, PIK3CA
biosynthetic process (GO:0009058) 1.325ERBB2, FGFR2, IRF1, KLF6, PIK3CA
regulation of catalytic activity (GO:0050790) 1.975APC, ERBB2, FGFR2, KRAS, PIK3CA
regulation of biosynthetic process (GO:0009889) 1.375ERBB2, KRAS, FGFR2, IRF1, KLF6
regulation of nucleic acid-templated transcription (GO:1903506) 1.555ERBB2, KRAS, FGFR2, IRF1, KLF6
single-organism developmental process (GO:0044767) 1.495APC, ERBB2, KRAS, FGFR2, PIK3CA
response to stress (GO:0006950) 1.85MUTYH, APC, ERBB2, IRF1, KLF6
regulation of RNA biosynthetic process (GO:2001141) 1.555ERBB2, KRAS, FGFR2, IRF1, KLF6
regulation of intracellular signal transduction (GO:1902531) 2.315ERBB2, KRAS, FGFR2, CASP10, PIK3CA
regulation of phosphorylation (GO:0042325) 2.55APC, ERBB2, KRAS, PIK3CA, FGFR2
regulation of phosphorus metabolic process (GO:0051174) 2.355APC, ERBB2, FGFR2, KRAS, PIK3CA
regulation of cellular protein metabolic process (GO:0032268) 1.995APC, ERBB2, KRAS, FGFR2, PIK3CA
single-multicellular organism process (GO:0044707) 1.785APC, IRF1, KRAS, PIK3CA, FGFR2
regulation of RNA metabolic process (GO:0051252) 1.525ERBB2, KRAS, FGFR2, IRF1, KLF6
macromolecule modification (GO:0043412) 1.735MUTYH, ERBB2, KRAS, FGFR2, PIK3CA
regulation of transcription, DNA-templated (GO:0006355) 1.565ERBB2, KRAS, FGFR2, IRF1, KLF6
regulation of macromolecule biosynthetic process (GO:0010556) 1.435ERBB2, KRAS, FGFR2, IRF1, KLF6
regulation of protein phosphorylation (GO:0001932) 2.575APC, ERBB2, FGFR2, KRAS, PIK3CA
positive regulation of biosynthetic process (GO:0009891) 2.294ERBB2, FGFR2, IRF1, KLF6
immune system process (GO:0002376) 2.294KLF6, IRF1, KRAS, PIK3CA
movement of cell or subcellular component (GO:0006928) 2.614APC, ERBB2, KRAS, PIK3CA
positive regulation of signaling (GO:0023056) 2.414ERBB2, KRAS, FGFR2, CASP10
cellular nitrogen compound metabolic process (GO:0034641) 1.224MUTYH, IRF1, KLF6, ERBB2
nitrogen compound metabolic process (GO:0006807) 1.134MUTYH, ERBB2, IRF1, KLF6
positive regulation of cellular biosynthetic process (GO:0031328) 2.34ERBB2, FGFR2, IRF1, KLF6
enzyme linked receptor protein signaling pathway (GO:0007167) 3.244ERBB2, KRAS, FGFR2, PIK3CA
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.544ERBB2, KRAS, FGFR2, PIK3CA
intracellular signal transduction (GO:0035556) 2.394ERBB2, KRAS, FGFR2, PIK3CA
regulation of cell death (GO:0010941) 2.434APC, KRAS, PIK3CA, CASP10
regulation of apoptotic process (GO:0042981) 2.54APC, KRAS, PIK3CA, CASP10
positive regulation of cell communication (GO:0010647) 2.414ERBB2, KRAS, FGFR2, CASP10
organic cyclic compound metabolic process (GO:1901360) 1.264MUTYH, ERBB2, IRF1, KLF6
cellular protein metabolic process (GO:0044267) 1.634ERBB2, KRAS, FGFR2, PIK3CA
single-organism metabolic process (GO:0044710) 1.634ERBB2, KRAS, FGFR2, PIK3CA
positive regulation of signal transduction (GO:0009967) 2.54ERBB2, KRAS, FGFR2, CASP10
positive regulation of phosphorus metabolic process (GO:0010562) 2.784ERBB2, KRAS, FGFR2, PIK3CA
regulation of kinase activity (GO:0043549) 3.074APC, ERBB2, KRAS, PIK3CA
phosphate-containing compound metabolic process (GO:0006796) 2.164ERBB2, KRAS, FGFR2, PIK3CA
regulation of programmed cell death (GO:0043067) 2.494APC, KRAS, PIK3CA, CASP10
animal organ development (GO:0048513) 2.534APC, ERBB2, FGFR2, PIK3CA
regulation of immune system process (GO:0002682) 2.54ERBB2, KRAS, IRF1, PIK3CA
positive regulation of catalytic activity (GO:0043085) 2.44ERBB2, KRAS, FGFR2, PIK3CA
positive regulation of molecular function (GO:0044093) 2.234ERBB2, KRAS, FGFR2, PIK3CA
phosphorylation (GO:0016310) 2.634ERBB2, KRAS, FGFR2, PIK3CA
positive regulation of cellular protein metabolic process (GO:0032270) 2.494ERBB2, KRAS, FGFR2, PIK3CA
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.564ERBB2, FGFR2, IRF1, KLF6
negative regulation of cell proliferation (GO:0008285) 3.264APC, ERBB2, IRF1, FGFR2
protein phosphorylation (GO:0006468) 2.894ERBB2, KRAS, FGFR2, PIK3CA
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.354ERBB2, FGFR2, IRF1, KLF6
positive regulation of phosphate metabolic process (GO:0045937) 2.784ERBB2, KRAS, FGFR2, PIK3CA
nucleobase-containing compound metabolic process (GO:0006139) 1.354IRF1, MUTYH, ERBB2, KLF6
regulation of developmental process (GO:0050793) 2.14ERBB2, FGFR2, IRF1, PIK3CA
regulation of protein kinase activity (GO:0045859) 3.154APC, ERBB2, PIK3CA, KRAS
cellular aromatic compound metabolic process (GO:0006725) 1.34IRF1, MUTYH, ERBB2, KLF6
cellular protein modification process (GO:0006464) 1.794ERBB2, KRAS, FGFR2, PIK3CA
protein modification process (GO:0036211) 1.794ERBB2, KRAS, FGFR2, PIK3CA
positive regulation of transcription, DNA-templated (GO:0045893) 2.564ERBB2, FGFR2, IRF1, KLF6
regulation of multicellular organismal process (GO:0051239) 1.874ERBB2, FGFR2, IRF1, PIK3CA
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.294ERBB2, FGFR2, IRF1, KLF6
positive regulation of intracellular signal transduction (GO:1902533) 2.954ERBB2, KRAS, FGFR2, CASP10
heterocycle metabolic process (GO:0046483) 1.314IRF1, MUTYH, ERBB2, KLF6
nucleic acid metabolic process (GO:0090304) 1.464MUTYH, ERBB2, IRF1, KLF6
positive regulation of phosphorylation (GO:0042327) 2.94ERBB2, KRAS, FGFR2, PIK3CA
positive regulation of protein modification process (GO:0031401) 2.74ERBB2, KRAS, FGFR2, PIK3CA
positive regulation of RNA metabolic process (GO:0051254) 2.514ERBB2, FGFR2, IRF1, KLF6
regulation of transferase activity (GO:0051338) 2.884APC, ERBB2, PIK3CA, KRAS
positive regulation of RNA biosynthetic process (GO:1902680) 2.544ERBB2, FGFR2, IRF1, KLF6
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.394ERBB2, FGFR2, IRF1, KLF6
phosphorus metabolic process (GO:0006793) 2.154ERBB2, KRAS, FGFR2, PIK3CA
positive regulation of protein phosphorylation (GO:0001934) 2.954ERBB2, KRAS, FGFR2, PIK3CA
negative regulation of metabolic process (GO:0009892) 1.933APC, IRF1, FGFR2
RNA biosynthetic process (GO:0032774) 1.843ERBB2, IRF1, KLF6
positive regulation of kinase activity (GO:0033674) 3.543ERBB2, KRAS, PIK3CA
regulation of cell activation (GO:0050865) 3.533ERBB2, IRF1, PIK3CA
regulation of cell adhesion (GO:0030155) 3.273ERBB2, IRF1, PIK3CA
negative regulation of cellular metabolic process (GO:0031324) 2.013APC, IRF1, FGFR2
regulation of T cell activation (GO:0050863) 4.053ERBB2, IRF1, PIK3CA
regulation of cell-cell adhesion (GO:0022407) 3.793ERBB2, IRF1, PIK3CA
ERBB2 signaling pathway (GO:0038128) 6.093ERBB2, KRAS, PIK3CA
cellular macromolecule biosynthetic process (GO:0034645) 1.663ERBB2, IRF1, KLF6
cell death (GO:0008219) 3.053IRF1, FGFR2, CASP10
regulation of protein serine/threonine kinase activity (GO:0071900) 3.583APC, ERBB2, KRAS
organic cyclic compound biosynthetic process (GO:1901362) 1.663ERBB2, IRF1, KLF6
cellular lipid metabolic process (GO:0044255) 2.923ERBB2, FGFR2, PIK3CA
nucleic acid-templated transcription (GO:0097659) 1.913ERBB2, IRF1, KLF6
regulation of MAPK cascade (GO:0043408) 3.223ERBB2, KRAS, FGFR2
response to endogenous stimulus (GO:0009719) 2.793APC, KLF6, KRAS
regulation of lymphocyte activation (GO:0051249) 3.733ERBB2, IRF1, PIK3CA
positive regulation of transferase activity (GO:0051347) 3.313ERBB2, KRAS, PIK3CA
phosphatidylinositol-mediated signaling (GO:0048015) 4.933ERBB2, FGFR2, PIK3CA
glycerophospholipid metabolic process (GO:0006650) 4.133ERBB2, FGFR2, PIK3CA
positive regulation of protein kinase activity (GO:0045860) 3.613ERBB2, KRAS, PIK3CA
MAPK cascade (GO:0000165) 3.913ERBB2, KRAS, FGFR2
lipid phosphorylation (GO:0046834) 5.133ERBB2, FGFR2, PIK3CA
inositol lipid-mediated signaling (GO:0048017) 4.913ERBB2, FGFR2, PIK3CA
phosphatidylinositol phosphorylation (GO:0046854) 5.193ERBB2, FGFR2, PIK3CA
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.813IRF1, FGFR2, KLF6
signal transduction by protein phosphorylation (GO:0023014) 3.793ERBB2, KRAS, FGFR2
cell migration (GO:0016477) 3.123APC, KRAS, PIK3CA
heterocycle biosynthetic process (GO:0018130) 1.73ERBB2, IRF1, KLF6
positive regulation of cell proliferation (GO:0008284) 3.013ERBB2, KRAS, FGFR2
response to oxygen-containing compound (GO:1901700) 2.573APC, PIK3CA, KLF6
phospholipid metabolic process (GO:0006644) 3.883ERBB2, FGFR2, PIK3CA
lipid metabolic process (GO:0006629) 2.683ERBB2, FGFR2, PIK3CA
apoptotic process (GO:0006915) 3.143IRF1, FGFR2, CASP10
positive regulation of MAPK cascade (GO:0043410) 3.573ERBB2, KRAS, FGFR2
programmed cell death (GO:0012501) 3.13IRF1, FGFR2, CASP10
cell activation (GO:0001775) 3.473IRF1, KLF6, PIK3CA
macromolecule biosynthetic process (GO:0009059) 1.613ERBB2, IRF1, KLF6
phosphatidylinositol metabolic process (GO:0046488) 4.463ERBB2, FGFR2, PIK3CA
locomotion (GO:0040011) 2.913APC, KRAS, PIK3CA
nucleobase-containing compound biosynthetic process (GO:0034654) 1.723ERBB2, IRF1, KLF6
negative regulation of macromolecule metabolic process (GO:0010605) 2.013APC, IRF1, FGFR2
glycerolipid metabolic process (GO:0046486) 3.913ERBB2, FGFR2, PIK3CA
regulation of phosphatidylinositol 3-kinase signaling (GO:0014066) 4.793ERBB2, FGFR2, PIK3CA
lipid modification (GO:0030258) 4.373ERBB2, FGFR2, PIK3CA
leukocyte differentiation (GO:0002521) 4.133IRF1, KLF6, CASP10
RNA metabolic process (GO:0016070) 1.593ERBB2, IRF1, KLF6
regulation of immune response (GO:0050776) 2.983IRF1, KRAS, PIK3CA
cellular nitrogen compound biosynthetic process (GO:0044271) 1.593ERBB2, IRF1, KLF6
regulation of biological quality (GO:0065008) 1.683IRF1, KRAS, PIK3CA
regulation of cell cycle (GO:0051726) 2.933APC, IRF1, FGFR2
cell motility (GO:0048870) 3.023APC, KRAS, PIK3CA
regulation of leukocyte activation (GO:0002694) 3.63ERBB2, IRF1, PIK3CA
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.243IRF1, FGFR2, KLF6
regulation of multicellular organismal development (GO:2000026) 2.313ERBB2, IRF1, FGFR2
transcription, DNA-templated (GO:0006351) 1.913ERBB2, IRF1, KLF6
cellular response to stress (GO:0033554) 2.513APC, MUTYH, KLF6
organophosphate metabolic process (GO:0019637) 3.043ERBB2, FGFR2, PIK3CA
aromatic compound biosynthetic process (GO:0019438) 1.73ERBB2, IRF1, KLF6
regulation of leukocyte cell-cell adhesion (GO:1903037) 4.013ERBB2, IRF1, PIK3CA
regulation of growth (GO:0040008) 3.263ERBB2, FGFR2, PIK3CA
negative regulation of cell differentiation (GO:0045596) 3.333ERBB2, IRF1, KRAS
ERBB signaling pathway (GO:0038127) 5.363ERBB2, KRAS, PIK3CA
cytokine-mediated signaling pathway (GO:0019221) 3.62IRF1, KRAS
cell development (GO:0048468) 3.282KRAS, FGFR2
regulation of Wnt signaling pathway (GO:0030111) 3.982APC, FGFR2
regulation of neuron apoptotic process (GO:0043523) 4.472KRAS, PIK3CA
negative regulation of neuron apoptotic process (GO:0043524) 4.822KRAS, PIK3CA
regulation of defense response (GO:0031347) 3.112IRF1, KRAS
morphogenesis of an epithelium (GO:0002009) 4.082KRAS, FGFR2
single-organism biosynthetic process (GO:0044711) 2.82FGFR2, PIK3CA
negative regulation of cell cycle (GO:0045786) 3.672APC, IRF1
positive regulation of cell adhesion (GO:0045785) 3.792ERBB2, PIK3CA
peptidyl-tyrosine modification (GO:0018212) 4.472ERBB2, FGFR2
response to growth factor (GO:0070848) 4.142APC, ERBB2
peptidyl-amino acid modification (GO:0018193) 2.982ERBB2, FGFR2
phosphatidylinositol biosynthetic process (GO:0006661) 4.942FGFR2, PIK3CA
system process (GO:0003008) 2.32KRAS, PIK3CA
negative regulation of cell death (GO:0060548) 2.952KRAS, PIK3CA
regulation of T cell proliferation (GO:0042129) 4.742ERBB2, IRF1
lymphocyte activation (GO:0046649) 3.962IRF1, KLF6
epidermal growth factor receptor signaling pathway (GO:0007173) 5.722KRAS, PIK3CA
regulation of epithelial cell proliferation (GO:0050678) 4.062ERBB2, FGFR2
neuron projection guidance (GO:0097485) 4.432ERBB2, KRAS
regulation of hemopoiesis (GO:1903706) 4.02ERBB2, IRF1
negative regulation of hemopoiesis (GO:1903707) 4.962ERBB2, IRF1
multi-organism process (GO:0051704) 2.652IRF1, KRAS
single organism signaling (GO:0044700) 3.252KRAS, FGFR2
immune response-activating cell surface receptor signaling pathway (GO:0002429) 4.062KRAS, PIK3CA
negative regulation of T cell differentiation (GO:0045581) 6.262ERBB2, IRF1
negative regulation of cell adhesion (GO:0007162) 4.332ERBB2, IRF1
regulation of cellular component organization (GO:0051128) 2.012APC, ERBB2
regulation of canonical Wnt signaling pathway (GO:0060828) 4.262APC, FGFR2
positive regulation of GTPase activity (GO:0043547) 3.282ERBB2, FGFR2
negative regulation of biosynthetic process (GO:0009890) 2.472IRF1, FGFR2
regulation of anatomical structure morphogenesis (GO:0022603) 2.792ERBB2, FGFR2
leukocyte activation (GO:0045321) 3.762IRF1, KLF6
negative regulation of gene expression (GO:0010629) 2.482IRF1, FGFR2
morphogenesis of a branching structure (GO:0001763) 4.712KRAS, FGFR2
regulation of mononuclear cell proliferation (GO:0032944) 4.452ERBB2, IRF1
axon guidance (GO:0007411) 4.442ERBB2, KRAS
positive regulation of protein serine/threonine kinase activity (GO:0071902) 4.062ERBB2, KRAS
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.552IRF1, FGFR2
immune response-regulating signaling pathway (GO:0002764) 3.722KRAS, PIK3CA
positive regulation of hydrolase activity (GO:0051345) 2.912ERBB2, FGFR2
immune response-regulating cell surface receptor signaling pathway (GO:0002768) 3.962KRAS, PIK3CA
positive regulation of immune system process (GO:0002684) 2.962KRAS, PIK3CA
negative regulation of immune system process (GO:0002683) 3.852ERBB2, IRF1
anatomical structure formation involved in morphogenesis (GO:0048646) 3.012FGFR2, PIK3CA
positive regulation of cellular component organization (GO:0051130) 2.682APC, ERBB2
tissue development (GO:0009888) 3.272FGFR2, PIK3CA
wound healing (GO:0042060) 5.132ERBB2, KLF6
cell cycle arrest (GO:0007050) 4.692APC, IRF1
glycerophospholipid biosynthetic process (GO:0046474) 4.622FGFR2, PIK3CA
regulation of neuron death (GO:1901214) 4.192KRAS, PIK3CA
negative regulation of neuron death (GO:1901215) 4.572KRAS, PIK3CA
organophosphate biosynthetic process (GO:0090407) 3.672FGFR2, PIK3CA
regulation of hydrolase activity (GO:0051336) 2.532ERBB2, FGFR2
immune response-activating signal transduction (GO:0002757) 3.82KRAS, PIK3CA
Fc receptor signaling pathway (GO:0038093) 4.452KRAS, PIK3CA
phospholipid biosynthetic process (GO:0008654) 4.392FGFR2, PIK3CA
regulation of response to stress (GO:0080134) 2.532IRF1, KRAS
negative regulation of leukocyte activation (GO:0002695) 4.792ERBB2, IRF1
regulation of cell motility (GO:2000145) 3.162APC, ERBB2
response to alcohol (GO:0097305) 4.582APC, KLF6
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532IRF1, FGFR2
regulation of developmental growth (GO:0048638) 4.042FGFR2, PIK3CA
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472IRF1, FGFR2
response to wounding (GO:0009611) 4.392ERBB2, KLF6
regulation of T cell differentiation (GO:0045580) 5.072ERBB2, IRF1
positive regulation of MAP kinase activity (GO:0043406) 4.392ERBB2, KRAS
regulation of MAP kinase activity (GO:0043405) 3.952ERBB2, KRAS
signaling (GO:0023052) 3.252KRAS, FGFR2
regulation of microtubule-based process (GO:0032886) 4.792APC, ERBB2
anatomical structure morphogenesis (GO:0009653) 2.532KRAS, FGFR2
regulation of GTPase activity (GO:0043087) 3.212ERBB2, FGFR2
protein autophosphorylation (GO:0046777) 4.462ERBB2, FGFR2
response to organic cyclic compound (GO:0014070) 3.072KRAS, KLF6
negative regulation of T cell activation (GO:0050868) 5.262ERBB2, IRF1
positive regulation of multicellular organismal process (GO:0051240) 2.492IRF1, FGFR2
negative regulation of multicellular organismal process (GO:0051241) 2.842ERBB2, IRF1
cell adhesion (GO:0007155) 2.822APC, IRF1
negative regulation of leukocyte cell-cell adhesion (GO:1903038) 5.192ERBB2, IRF1
negative regulation of cellular biosynthetic process (GO:0031327) 2.492IRF1, FGFR2
glycerolipid biosynthetic process (GO:0045017) 4.532FGFR2, PIK3CA
negative regulation of lymphocyte differentiation (GO:0045620) 6.042ERBB2, IRF1
biological adhesion (GO:0022610) 2.812APC, IRF1
cellular response to endogenous stimulus (GO:0071495) 3.332APC, KLF6
cellular response to oxygen-containing compound (GO:1901701) 3.222KLF6, PIK3CA
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712IRF1, FGFR2
cellular response to DNA damage stimulus (GO:0006974) 3.172APC, MUTYH
regulation of locomotion (GO:0040012) 3.122APC, ERBB2
negative regulation of transcription, DNA-templated (GO:0045892) 2.752IRF1, FGFR2
proteolysis (GO:0006508) 2.732APC, CASP10
regulation of localization (GO:0032879) 1.942APC, ERBB2
response to oxidative stress (GO:0006979) 3.92MUTYH, KLF6
negative regulation of developmental process (GO:0051093) 3.172ERBB2, IRF1
cellular response to growth factor stimulus (GO:0071363) 4.272APC, ERBB2
positive regulation of epithelial cell proliferation (GO:0050679) 4.672ERBB2, FGFR2
negative regulation of lymphocyte activation (GO:0051250) 4.952ERBB2, IRF1
negative regulation of RNA metabolic process (GO:0051253) 2.662IRF1, FGFR2
regulation of lymphocyte proliferation (GO:0050670) 4.462ERBB2, IRF1
positive regulation of immune response (GO:0050778) 3.42KRAS, PIK3CA
regulation of lymphocyte differentiation (GO:0045619) 4.842ERBB2, IRF1
lymphocyte differentiation (GO:0030098) 4.492IRF1, KLF6
system development (GO:0048731) 2.922ERBB2, PIK3CA
gland development (GO:0048732) 4.152FGFR2, PIK3CA
regulation of ERK1 and ERK2 cascade (GO:0070372) 4.232ERBB2, FGFR2
positive regulation of growth (GO:0045927) 4.252ERBB2, FGFR2
cell projection organization (GO:0030030) 3.142APC, FGFR2
negative regulation of cell activation (GO:0050866) 4.672ERBB2, IRF1
peptidyl-tyrosine phosphorylation (GO:0018108) 4.482ERBB2, FGFR2
homeostatic process (GO:0042592) 2.612KRAS, PIK3CA
leukocyte migration (GO:0050900) 4.192KRAS, PIK3CA
cell cycle process (GO:0022402) 2.752APC, IRF1
angiogenesis (GO:0001525) 4.152FGFR2, PIK3CA
negative regulation of cell-cell adhesion (GO:0022408) 4.842ERBB2, IRF1
pattern specification process (GO:0007389) 3.792APC, FGFR2
cell proliferation (GO:0008283) 3.232ERBB2, FGFR2
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62IRF1, FGFR2
regulation of leukocyte proliferation (GO:0070663) 4.42ERBB2, IRF1
negative regulation of apoptotic process (GO:0043066) 3.042KRAS, PIK3CA
tissue morphogenesis (GO:0048729) 3.872KRAS, FGFR2
negative regulation of programmed cell death (GO:0043069) 3.022KRAS, PIK3CA
regulation of innate immune response (GO:0045088) 3.862IRF1, KRAS
morphogenesis of a branching epithelium (GO:0061138) 4.772KRAS, FGFR2
Fc-epsilon receptor signaling pathway (GO:0038095) 4.842KRAS, PIK3CA
negative regulation of RNA biosynthetic process (GO:1902679) 2.72IRF1, FGFR2
cellular component disassembly (GO:0022411) 3.522APC, PIK3CA
phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) 5.842FGFR2, PIK3CA
single-organism organelle organization (GO:1902589) 2.682KRAS, PIK3CA
cell-cell signaling (GO:0007267) 3.352KRAS, FGFR2
cell communication (GO:0007154) 3.042KRAS, FGFR2
lipid biosynthetic process (GO:0008610) 3.492FGFR2, PIK3CA
organelle organization (GO:0006996) 2.022KRAS, PIK3CA
response to abiotic stimulus (GO:0009628) 2.82IRF1, KRAS
regulation of cellular component movement (GO:0051270) 3.082APC, ERBB2
regulation of multicellular organism growth (GO:0040014) 5.482FGFR2, PIK3CA
negative regulation of leukocyte differentiation (GO:1902106) 5.32ERBB2, IRF1
regulation of leukocyte differentiation (GO:1902105) 4.262ERBB2, IRF1
activation of immune response (GO:0002253) 3.672KRAS, PIK3CA
immune effector process (GO:0002252) 3.582IRF1, PIK3CA

NET-GE enrichment

Term New enriched termICP valueGenes
hemostasis (GO:0007599) NEW4.50.024APC, FGFR2, IRF1, KRAS, ERBB2, PIK3CA
positive regulation of metabolic process (GO:0009893) -1.740.018APC, FGFR2, IRF1, PIK3CA, ERBB2, KRAS, KLF6
regulation of cell adhesion (GO:0030155) -3.270.0APC, FGFR2, IRF1, PIK3CA, ERBB2, KRAS, KLF6
cell differentiation (GO:0030154) -2.140.03APC, FGFR2, IRF1, KRAS, ERBB2, KLF6
apoptotic signaling pathway (GO:0097190) NEW4.120.003CASP10, FGFR2, IRF1, KRAS, ERBB2, PIK3CA
negative regulation of epithelial cell proliferation (GO:0050680) NEW4.980.03APC, ERBB2, KRAS, FGFR2
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) -2.60.011APC, FGFR2, CASP10, IRF1, PIK3CA, ERBB2, KRAS, MUTYH
leukocyte activation (GO:0045321) -3.760.018APC, IRF1, KRAS, ERBB2, PIK3CA, KLF6
negative regulation of gene expression (GO:0010629) -2.480.01APC, FGFR2, CASP10, IRF1, PIK3CA, ERBB2, KRAS, KLF6
positive regulation of mononuclear cell proliferation (GO:0032946) NEW4.840.001ERBB2, KRAS, FGFR2, IRF1, PIK3CA
ERBB signaling pathway (GO:0038127) -5.360.001ERBB2, KRAS, FGFR2, PIK3CA
regulation of mononuclear cell proliferation (GO:0032944) -4.450.006ERBB2, KRAS, FGFR2, IRF1, PIK3CA
positive regulation of cell death (GO:0010942) NEW3.320.028APC, FGFR2, IRF1, KRAS, ERBB2, PIK3CA
fibroblast growth factor receptor signaling pathway (GO:0008543) NEW5.30.001ERBB2, KRAS, FGFR2, PIK3CA
cellular response to fibroblast growth factor stimulus (GO:0044344) NEW6.40.001ERBB2, KRAS, FGFR2, PIK3CA
cellular response to stimulus (GO:0051716) -1.970.031APC, FGFR2, CASP10, MUTYH, PIK3CA, ERBB2, KRAS, KLF6, IRF1
negative regulation of cell cycle (GO:0045786) -3.670.001APC, FGFR2, IRF1, KRAS, ERBB2, PIK3CA
positive regulation of macromolecule metabolic process (GO:0010604) -1.810.009APC, FGFR2, IRF1, PIK3CA, ERBB2, KRAS, KLF6
positive regulation of hydrolase activity (GO:0051345) -2.910.042APC, FGFR2, IRF1, PIK3CA, ERBB2, KRAS, KLF6
positive regulation of cell adhesion (GO:0045785) -3.790.006APC, ERBB2, IRF1, FGFR2, PIK3CA
immune response-regulating cell surface receptor signaling pathway (GO:0002768) -3.960.038ERBB2, KRAS, FGFR2, PIK3CA
regulation of leukocyte proliferation (GO:0070663) -4.40.006ERBB2, KRAS, FGFR2, IRF1, PIK3CA
positive regulation of apoptotic process (GO:0043065) NEW3.380.016APC, FGFR2, IRF1, KRAS, ERBB2, PIK3CA
cellular response to organic substance (GO:0071310) -2.780.034FGFR2, IRF1, KRAS, ERBB2, PIK3CA, KLF6
positive regulation of leukocyte proliferation (GO:0070665) NEW4.790.001ERBB2, KRAS, FGFR2, IRF1, PIK3CA
leukocyte differentiation (GO:0002521) -4.130.001APC, IRF1, KRAS, ERBB2, PIK3CA, KLF6
regulation of immune system process (GO:0002682) -2.50.009APC, FGFR2, IRF1, KRAS, ERBB2, PIK3CA
hematopoietic or lymphoid organ development (GO:0048534) NEW4.490.008APC, ERBB2, FGFR2, KRAS, PIK3CA
cell migration (GO:0016477) -3.120.024APC, FGFR2, IRF1, PIK3CA, ERBB2, KRAS, KLF6
positive regulation of programmed cell death (GO:0043068) NEW3.380.017APC, FGFR2, IRF1, KRAS, ERBB2, PIK3CA
insulin receptor signaling pathway (GO:0008286) NEW5.330.037ERBB2, KRAS, FGFR2, PIK3CA
neurotrophin signaling pathway (GO:0038179) NEW6.550.005APC, ERBB2, KRAS, PIK3CA, FGFR2
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) -2.550.013APC, FGFR2, CASP10, MUTYH, PIK3CA, ERBB2, KRAS, IRF1
regulation of body fluid levels (GO:0050878) NEW3.760.004APC, FGFR2, IRF1, PIK3CA, ERBB2, KRAS, KLF6
innate immune response (GO:0045087) NEW3.550.014APC, CASP10, FGFR2, IRF1, PIK3CA, ERBB2, KRAS
apoptotic process (GO:0006915) -3.140.014APC, CASP10, FGFR2, IRF1, PIK3CA, ERBB2, KRAS
extrinsic apoptotic signaling pathway (GO:0097191) NEW5.160.007IRF1, PIK3CA, CASP10, ERBB2
defense response (GO:0006952) NEW2.780.008CASP10, FGFR2, IRF1, KRAS, ERBB2, PIK3CA
programmed cell death (GO:0012501) -3.10.016APC, CASP10, FGFR2, IRF1, PIK3CA, ERBB2, KRAS
response to stress (GO:0006950) -1.80.002APC, FGFR2, CASP10, MUTYH, PIK3CA, ERBB2, KRAS, IRF1
Fc-epsilon receptor signaling pathway (GO:0038095) -4.840.007ERBB2, KRAS, FGFR2, PIK3CA
epidermal growth factor receptor signaling pathway (GO:0007173) -5.720.001ERBB2, KRAS, FGFR2, PIK3CA
central nervous system neuron development (GO:0021954) NEW6.260.015ERBB2, FGFR2, PIK3CA
neurotrophin TRK receptor signaling pathway (GO:0048011) NEW6.960.017APC, ERBB2, KRAS, FGFR2, PIK3CA
phosphatidylinositol-mediated signaling (GO:0048015) -4.930.029ERBB2, FGFR2, PIK3CA
inositol lipid-mediated signaling (GO:0048017) -4.910.029ERBB2, FGFR2, PIK3CA
regulation of immune response (GO:0050776) -2.980.031ERBB2, KRAS, FGFR2, IRF1, PIK3CA
Fc receptor signaling pathway (GO:0038093) -4.450.013ERBB2, KRAS, FGFR2, PIK3CA
cell motility (GO:0048870) -3.020.045APC, FGFR2, IRF1, PIK3CA, ERBB2, KRAS, KLF6
positive regulation of lymphocyte activation (GO:0051251) NEW4.070.033ERBB2, KRAS, FGFR2, IRF1, PIK3CA
regulation of peptidyl-tyrosine phosphorylation (GO:0050730) NEW4.350.008ERBB2, KRAS, FGFR2, IRF1, PIK3CA
response to nitrogen compound (GO:1901698) NEW3.120.028APC, CASP10, FGFR2, IRF1, PIK3CA, ERBB2, KRAS
regulation of lymphocyte proliferation (GO:0050670) -4.460.005ERBB2, KRAS, FGFR2, IRF1, PIK3CA
positive regulation of lymphocyte proliferation (GO:0050671) NEW4.850.001ERBB2, KRAS, FGFR2, IRF1, PIK3CA
immune system process (GO:0002376) -2.290.0APC, FGFR2, CASP10, IRF1, PIK3CA, ERBB2, KRAS, KLF6
positive regulation of leukocyte activation (GO:0002696) NEW4.00.048ERBB2, KRAS, FGFR2, IRF1, PIK3CA
response to peptide (GO:1901652) NEW3.940.01APC, FGFR2, IRF1, KRAS, ERBB2, PIK3CA
lymphocyte differentiation (GO:0030098) -4.490.007APC, KLF6, ERBB2, IRF1, KRAS
response to fibroblast growth factor (GO:0071774) NEW6.170.001ERBB2, KRAS, FGFR2, PIK3CA
positive regulation of cellular process (GO:0048522) -1.30.023APC, FGFR2, CASP10, IRF1, PIK3CA, ERBB2, KRAS, KLF6
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.289APC, FGFR2, CASP10, MUTYH, PIK3CA, ERBB2, KRAS, KLF6, IRF1
cell part (GO:0044464) 0.119APC, FGFR2, CASP10, MUTYH, PIK3CA, ERBB2, KRAS, KLF6, IRF1
cytoplasmic part (GO:0044444) 0.828APC, FGFR2, CASP10, MUTYH, PIK3CA, ERBB2, KRAS, IRF1
intracellular organelle (GO:0043229) 0.517APC, FGFR2, MUTYH, KRAS, ERBB2, KLF6, IRF1
membrane-bounded organelle (GO:0043227) 0.477APC, FGFR2, MUTYH, KRAS, ERBB2, KLF6, IRF1
intracellular membrane-bounded organelle (GO:0043231) 0.67APC, FGFR2, MUTYH, KRAS, ERBB2, KLF6, IRF1
organelle (GO:0043226) 0.47APC, FGFR2, MUTYH, KRAS, ERBB2, KLF6, IRF1
membrane part (GO:0044425) 0.956APC, CASP10, FGFR2, KRAS, ERBB2, PIK3CA
nucleus (GO:0005634) 1.076APC, FGFR2, MUTYH, ERBB2, KLF6, IRF1
cytoplasm (GO:0005737) 1.015APC, ERBB2, KRAS, IRF1, FGFR2
macromolecular complex (GO:0032991) 1.355APC, ERBB2, IRF1, CASP10, PIK3CA
cytosol (GO:0005829) 1.685APC, IRF1, KRAS, PIK3CA, CASP10
membrane (GO:0016020) 0.685APC, ERBB2, FGFR2, KRAS, PIK3CA
intracellular organelle part (GO:0044446) 0.815APC, MUTYH, IRF1, FGFR2, ERBB2
plasma membrane (GO:0005886) 1.395APC, ERBB2, KRAS, FGFR2, PIK3CA
plasma membrane part (GO:0044459) 1.955APC, ERBB2, KRAS, CASP10, FGFR2
organelle part (GO:0044422) 0.795APC, MUTYH, IRF1, FGFR2, ERBB2
protein complex (GO:0043234) 1.514APC, ERBB2, PIK3CA, CASP10
nucleoplasm (GO:0005654) 1.894APC, MUTYH, IRF1, FGFR2
nuclear part (GO:0044428) 1.554APC, MUTYH, IRF1, FGFR2
membrane protein complex (GO:0098796) 2.843APC, PIK3CA, CASP10
plasma membrane region (GO:0098590) 2.972APC, ERBB2
chromosomal part (GO:0044427) 3.182APC, IRF1
vesicle (GO:0031982) 1.642ERBB2, FGFR2
adherens junction (GO:0005912) 3.662APC, KRAS
lamellipodium (GO:0030027) 4.732APC, PIK3CA
cytoplasmic vesicle (GO:0031410) 2.872ERBB2, FGFR2
integral component of membrane (GO:0016021) 1.142ERBB2, FGFR2
anchoring junction (GO:0070161) 3.612APC, KRAS
intracellular (GO:0005622) 2.372KRAS, PIK3CA
organelle membrane (GO:0031090) 1.972APC, ERBB2
intrinsic component of membrane (GO:0031224) 1.132ERBB2, FGFR2
plasma membrane protein complex (GO:0098797) 3.552APC, CASP10
intracellular vesicle (GO:0097708) 2.862ERBB2, FGFR2
mitochondrion (GO:0005739) 2.422MUTYH, KRAS
cell cortex (GO:0005938) 4.782APC, FGFR2
synapse (GO:0045202) 3.582APC, FGFR2
cell projection (GO:0042995) 2.472APC, PIK3CA
cytoplasmic region (GO:0099568) 4.512APC, FGFR2
cell junction (GO:0030054) 2.752APC, KRAS
catalytic complex (GO:1902494) 2.92PIK3CA, CASP10

NET-GE enrichment

Term New enriched termICP valueGenes
Golgi apparatus part (GO:0044431) NEW3.00.034APC, FGFR2, IRF1, KRAS, ERBB2, PIK3CA
cytosolic part (GO:0044445) NEW4.340.002IRF1, KRAS, PIK3CA, CASP10
nuclear part (GO:0044428) -1.550.005APC, FGFR2, CASP10, IRF1, PIK3CA, ERBB2, KRAS, KLF6, MUTYH
nucleolus (GO:0005730) NEW3.060.017CASP10, MUTYH, PIK3CA, ERBB2, KLF6, IRF1