Gene table of MLH3 : mutL homolog 3

Gene-disease associations table

Disease IDDisease nameSource of annotation with MLH3OMIM linkNumber of associated genesgenes
114500COLORECTAL CANCEROMIM link to OMIM 30TLR4, RAD54B, PTPRJ, TP53, EP300, PTPN12, ODC1, FLCN, TLR2, BAX, PLA2G2A, AURKA, NRAS, APC, MCC, TRIM28, MLH3, AKT1, MT-CO1, AXIN2, CTNNB1, PDGFRL, PIK3CA, KAT5, DCC, BRAF, CCND1, FGFR3, DLC1, BUB1B
PS120435COLORECTAL CANCER, HEREDITARY NONPOLYPOSISClinVar, OMIM, HUMSAVAR link to OMIM 7TGFBR2, MSH6, PMS2, MLH3, EPCAM, MLH1, MSH2
608089ENDOMETRIAL CANCEROMIM link to OMIM 5MLH3, CDH1, MSH6, PTEN, MSH3

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Annotation of the gene MLH3

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST
Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Mismatch repairhsa034308.07
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Cell CycleR-HSA-16401703.89
MeiosisR-HSA-15006206.59
Meiotic recombinationR-HSA-9124467.25
Associated GO terms for Molecular function
GO termGO IDGO IC
ATPase activityGO:00168873.65
purine ribonucleoside triphosphate bindingGO:00356392.22
mismatched DNA bindingGO:00309837.25
macromolecular complex bindingGO:00448772.61
bindingGO:00054880.18
nucleic acid bindingGO:00036761.44
DNA bindingGO:00036771.92
heterocyclic compound bindingGO:19013631.06
purine nucleoside bindingGO:00018832.22
nucleoside bindingGO:00018822.21
sequence-specific DNA bindingGO:00435652.79
sequence-specific double-stranded DNA bindingGO:19908373.2
nucleotide bindingGO:00001661.96
nucleoside phosphate bindingGO:19012651.96
ribonucleoside bindingGO:00325492.22
purine nucleotide bindingGO:00170762.19
double-stranded DNA bindingGO:00036903.09
satellite DNA bindingGO:00036967.79
single-stranded DNA bindingGO:00036975.17
ATP bindingGO:00055242.43
hydrolase activityGO:00167871.9
centromeric DNA bindingGO:00192377.95
nucleoside-triphosphatase activityGO:00171113.09
small molecule bindingGO:00360941.89
catalytic activityGO:00038241.05
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydridesGO:00168183.03
adenyl nucleotide bindingGO:00305542.4
carbohydrate derivative bindingGO:00973672.03
organic cyclic compound bindingGO:00971591.05
hydrolase activity, acting on acid anhydridesGO:00168173.03
pyrophosphatase activityGO:00164623.04
adenyl ribonucleotide bindingGO:00325592.41
protein bindingGO:00055150.46
purine ribonucleotide bindingGO:00325552.2
chromatin bindingGO:00036823.64
purine ribonucleoside bindingGO:00325502.22
ribonucleotide bindingGO:00325532.19