Disease table of ENDOMETRIAL CANCER OMIM ID: 608089

Gene-disease associations table

GeneAssociated with ENDOMETRIAL CANCER inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
CDH1OMIMHGNC link16q22.15608089, 167000, 176807, 137215, 114480
PTENOMIM, HUMSAVARHGNC link10q23.3110276950, 608089, 275355, 176807, PS155600, PS137800, 605309, 607174, 153480, PS158350
MSH3OMIMHGNC link5q14.11608089
MLH3OMIMHGNC link14q24.33114500, 608089, PS120435
MSH6OMIMHGNC link2p16.33276300, PS120435, 608089

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
STAT3NO129IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP122PTEN, CDH1
NFKB1NO306NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC62PTEN, CDH1
RELANO302NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC62PTEN, CDH1
MTA1NO20EPHA2, NOS2, MMP9, EGFR, MNAT1, MTA3, SNAI1, SMAD7, BCL2L1, CDH1, MYC, CDKN1A, SNAI2, PTEN, ITGB3BP, ESR1, CDKN2A, SUMO2, BRCA1, TFF12PTEN, CDH1
ARNO83UGT2B15, PTPN1, CDH11, AKR1C3, USP26, FOLH1, CCR2, CDK20, CDK6, PNRC1, ARG1, XIAP, VIM, ARG2, EGFR, CFLAR, ETV1, BSG, IGF1R, MUC1, WEE1, PTGS2, NKX3-1, AKT1, NRAS, CDH1, EP300, KLF5, ACTA1, CLK3, FN1, TNF, PRL, ERBB2, ERBB3, CRISP3, CTNNB1, PTEN, CRISP1, SERPINB5, TSC2, NAT1, CDKN1A, GREB1, SEPT7, IFI16, PIGR, KLK3, PC, STIM1, SRD5A3, TCF7L2, JUN, TMPRSS2, RELA, TJP1, BTG1, VEGFA, NFKB1, HMMR, FKBP5, KLK4, CRH, CDH2, BTG2, TGFA, SESN1, CDC6, TH, ALDH1A3, KISS1, KISS1R, PEBP1, KLK2, ATAD2, HMOX1, TSC1, WNT7B, PEG10, TRPS1, CCND1, PIP, FOXA12PTEN, CDH1
TFAP2ANO69SLC19A1, POLD2, L1CAM, MCAM, GALNT3, CRYAB, KISS1, CGB, EGFR, HTT, GAST, COL1A1, NME3, PTGS2, SPRY2, ACHE, MUC4, DBH, FOXA1, GUSB, DCBLD2, IGFBP5, CFTR, HSD17B1, ERBB2, ETS1, CD82, CYP11A1, PVR, ADM, KRT5, KIT, CCNB1, HGF, F2R, ECM1, APP, MPG, CRABP2, CDH1, PTEN, KLF12, VEGFA, GPX4, SULT1E1, CGA, LNPEP, TIMP2, MMP9, HOXA4, TAF7, NR3C1, BCL2, PLAUR, TH, ADRA2B, MMP2, CDKN1A, FAS, ADRA1A, IMPDH2, SNAP91, PRKCA, HMOX1, BACE1, CRX, BRS3, HIP1, CSH12PTEN, CDH1
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
CDH1YES49AR, MTA2, FOXM1, ZEB2, SNAI1, TWIST2, TWIST1, EZH2, RBBP7, FOXA2, TCF3, LMO2, SPDEF, YBX1, KLF4, MTA1, LCOR, HDAC3, DNMT1, FOXQ1, HOXA7, TCF12, ESR1, SIRT1, WT1, ZEB1, FOSB, SMARCA4, VDR, HDAC1, TFAP2A, RELA, PARP1, HMGA2, NFKB1, KLF8, HDGF, STAT3, GATA3, HDAC2, SNAI2, CBX7, SALL4, RB1, HMGA1, KLF6, ZNF217, SIX1, HIF1A0
PTENYES15SP1, STAT3, EGR1, TCF4, NFKB1, MTA1, AR, TP53, HES1, TFAP2A, RELA, RBPJ, MXD1, PPARG, SRF0
MSH6YES1SP30
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
CDH1PTENYes9HSP90AA1, HSPA8, CDC27, CDH1, JUP, PPP1CA, CTNNB1, HSPD1, YES1
CDH1MSH3No1CDC42
CDH1MSH6No3CREBBP, EP300, XRCC5
PTENMLH3No1AR
PTENMSH6No3CSNK2A1, PRDX1, TP53
MSH3MLH3No2MYC, MLH1
MSH3MSH6Yes13MYC, PMS2, SMARCAD1, RAD1, MSH2, RAD9A, BARD1, HUS1, PCNA, NTRK1, SLX4, BRCA1, MLH1
MLH3MSH6No2MYC, MLH1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
CDH1PTENYesactivation, binding43AR, FOXM1, SNAI1, VCL, SMAD4, CAV1, CDX1, EGFR, HDAC9, FOS, IGF2BP1, DLG1, NRP2, SUMO1, CCND1, PIK3CA, MTA1, SMAD3, TGFB1, TGM2, TBX3, SMARCA4, IL8, RPS6KB1, JUN, TP53, AKT1, SRC, MTA3, FOXO3, RPTOR, NOTCH1, BCL2, CDC6, IGF1R, EZH2, IGF2, PIK3R1, CDX2, UBC, LEP, PPARG, RAC3
CDH1MSH6No-2UBC, TP53
PTENMSH6No-3SP1, UBC, TP53
MSH3MLH3Yesbinding15ERCC1, POLD1, PMS2, PCNA, WRN, MSH2, ERCC4, PMS1, POLE, RPA1, EXO1, MSH6, RECQL, RAD51, MLH1
MSH3MSH6Yesbinding34POLE4, PCNA, POLE3, FANCM, XPC, ERCC8, POLD1, RAD52, POLE, MSH2, RAD51, PMS1, SWSAP1, RECQL, CHRAC1, RAD51D, ERCC1, RAD23B, ZSWIM7, ALDH18A1, XRCC6BP1, EXO1, RAD51B, BRCA1, PMS2, WRN, XRCC4, XRCC6, ERCC4, XRCC5, OGG1, POLE2, MLH1, MLH3
MLH3MSH6Yesbinding15ERCC1, POLD1, MSH3, PCNA, WRN, MSH2, PMS1, ERCC4, BLM, POLE, PMS2, EXO1, RECQL, MLH1, RAD51

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
MSH3MSH6No-1MSH2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
MSH3MSH6Yes1MSH2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
MSH3MSH6No1MSH2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Pathways in cancerhsa052003.984MSH6, MSH3, PTEN, CDH1
Mismatch repairhsa034308.073MSH3, MSH6, MLH3
Endometrial cancerhsa052136.812PTEN, CDH1
Melanomahsa052186.562PTEN, CDH1
Colorectal cancerhsa052106.522MSH3, MSH6

NET-GE enrichment

Term New enriched termICP valueGenes
Melanoma (hsa05218) -6.560.047PTEN, CDH1
Cancers: Specific typesNEW4.10.002MSH6, MSH3, PTEN, CDH1
Endometrial cancer (hsa05213) -6.810.033PTEN, CDH1
Colorectal cancer (hsa05210) -6.520.049MSH3, MSH6
Pathways in cancer (hsa05200) -3.980.003MSH6, MSH3, PTEN, CDH1
Mismatch repair (hsa03430) -8.070.0MSH3, MSH6, MLH3
Replication and repairNEW5.410.005MSH6, MSH3, MLH3, PTEN
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
DNA RepairR-HSA-738945.82MSH3, MSH6
Immune SystemR-HSA-1682562.372PTEN, CDH1
Adaptive Immune SystemR-HSA-12802183.192PTEN, CDH1
Signal TransductionR-HSA-1625821.782PTEN, CDH1
Mismatch RepairR-HSA-53585089.082MSH3, MSH6

NET-GE enrichment

Term New enriched termICP valueGenes
Mismatch Repair (R-HSA-5358508) -9.080.002MSH3, MSH6
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.185MSH6, MLH3, MSH3, PTEN, CDH1
protein binding (GO:0005515) 0.465MSH6, MLH3, MSH3, PTEN, CDH1
carbohydrate derivative binding (GO:0097367) 2.034MSH6, MSH3, MLH3, CDH1
purine ribonucleoside triphosphate binding (GO:0035639) 2.223MSH3, MSH6, MLH3
mismatched DNA binding (GO:0030983) 7.253MSH3, MSH6, MLH3
macromolecular complex binding (GO:0044877) 2.613MSH6, MLH3, PTEN
nucleic acid binding (GO:0003676) 1.443MSH3, MSH6, MLH3
DNA binding (GO:0003677) 1.923MSH3, MSH6, MLH3
nucleotide binding (GO:0000166) 1.963MSH3, MSH6, MLH3
heterocyclic compound binding (GO:1901363) 1.063MSH3, MSH6, MLH3
nucleoside phosphate binding (GO:1901265) 1.963MSH3, MSH6, MLH3
nucleoside binding (GO:0001882) 2.213MSH3, MSH6, MLH3
cation binding (GO:0043169) 1.43MSH6, PTEN, CDH1
ion binding (GO:0043167) 1.363MSH6, PTEN, CDH1
purine nucleoside binding (GO:0001883) 2.223MSH3, MSH6, MLH3
ribonucleoside binding (GO:0032549) 2.223MSH3, MSH6, MLH3
purine nucleotide binding (GO:0017076) 2.193MSH3, MSH6, MLH3
double-stranded DNA binding (GO:0003690) 3.093MSH3, MSH6, MLH3
metal ion binding (GO:0046872) 1.413MSH6, PTEN, CDH1
identical protein binding (GO:0042802) 2.633MSH3, MSH6, PTEN
hydrolase activity (GO:0016787) 1.93MSH6, MLH3, PTEN
small molecule binding (GO:0036094) 1.893MSH3, MSH6, MLH3
catalytic activity (GO:0003824) 1.053MSH6, MLH3, PTEN
adenyl nucleotide binding (GO:0030554) 2.43MSH3, MSH6, MLH3
organic cyclic compound binding (GO:0097159) 1.053MSH3, MSH6, MLH3
adenyl ribonucleotide binding (GO:0032559) 2.413MSH3, MSH6, MLH3
ATP binding (GO:0005524) 2.433MSH3, MSH6, MLH3
purine ribonucleotide binding (GO:0032555) 2.23MSH3, MSH6, MLH3
purine ribonucleoside binding (GO:0032550) 2.223MSH3, MSH6, MLH3
ribonucleotide binding (GO:0032553) 2.193MSH3, MSH6, MLH3
oxidized purine DNA binding (GO:0032357) 8.132MSH3, MSH6
oxidized DNA binding (GO:0032356) 8.132MSH3, MSH6
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 3.032MSH6, MLH3
damaged DNA binding (GO:0003684) 5.582MSH3, MSH6
single guanine insertion binding (GO:0032142) 8.642MSH3, MSH6
nucleoside-triphosphatase activity (GO:0017111) 3.092MSH6, MLH3
magnesium ion binding (GO:0000287) 4.412MSH6, PTEN
hydrolase activity, acting on acid anhydrides (GO:0016817) 3.032MSH6, MLH3
enzyme binding (GO:0019899) 2.272MSH3, PTEN
protein complex binding (GO:0032403) 3.092MSH6, PTEN
pyrophosphatase activity (GO:0016462) 3.042MSH6, MLH3
single-stranded DNA binding (GO:0003697) 5.172MSH3, MLH3
ATPase activity (GO:0016887) 3.652MSH6, MLH3
single base insertion or deletion binding (GO:0032138) 8.352MSH3, MSH6
guanine/thymine mispair binding (GO:0032137) 8.352MSH3, MSH6
DNA insertion or deletion binding (GO:0032135) 7.952MSH3, MSH6
chromatin binding (GO:0003682) 3.642MSH6, MLH3
protein dimerization activity (GO:0046983) 2.722MSH3, MSH6
protein homodimerization activity (GO:0042803) 3.162MSH3, MSH6

NET-GE enrichment

Term New enriched termICP valueGenes
sequence-specific DNA binding (GO:0043565) NEW2.790.005MSH6, MLH3, MSH3, PTEN, CDH1
structure-specific DNA binding (GO:0043566) NEW4.980.0MSH6, MLH3, MSH3, PTEN, CDH1
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) -3.030.005MSH6, MLH3, MSH3, PTEN, CDH1
mismatched DNA binding (GO:0030983) -7.250.0MSH3, MSH6, MLH3
DNA-dependent ATPase activity (GO:0008094) NEW5.310.013MSH3, MSH6
centromeric DNA binding (GO:0019237) NEW7.950.0MSH3, MLH3, PTEN
chromatin binding (GO:0003682) -3.640.024MLH3, MSH6, PTEN, CDH1
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity (GO:0016314) NEW8.350.05MLH3, PTEN
hydrolase activity, acting on acid anhydrides (GO:0016817) -3.030.005MSH6, MLH3, MSH3, PTEN, CDH1
nucleoside-triphosphatase activity (GO:0017111) -3.090.003MSH6, MLH3, MSH3, PTEN, CDH1
frizzled binding (GO:0005109) NEW6.10.045PTEN, CDH1
ATPase activity (GO:0016887) -3.650.009MSH6, MSH3, MLH3, PTEN
double-stranded DNA binding (GO:0003690) -3.090.0MSH6, MLH3, MSH3, PTEN, CDH1
pyrophosphatase activity (GO:0016462) -3.040.005MSH6, MLH3, MSH3, PTEN, CDH1
coreceptor activity (GO:0015026) NEW6.10.041PTEN, CDH1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular response to stimulus (GO:0051716) 1.975MSH6, MLH3, MSH3, PTEN, CDH1
cellular process (GO:0009987) 0.265MSH6, MLH3, MSH3, PTEN, CDH1
response to stimulus (GO:0050896) 1.225MSH6, MLH3, MSH3, PTEN, CDH1
cellular component organization or biogenesis (GO:0071840) 1.225MSH6, MLH3, MSH3, PTEN, CDH1
cellular component organization (GO:0016043) 1.245MSH6, MLH3, MSH3, PTEN, CDH1
organelle organization (GO:0006996) 2.024MSH6, MSH3, MLH3, PTEN
primary metabolic process (GO:0044238) 0.694MSH6, MSH3, MLH3, PTEN
regulation of metabolic process (GO:0019222) 1.024MSH6, MSH3, PTEN, CDH1
cellular macromolecule metabolic process (GO:0044260) 0.934MSH6, MSH3, MLH3, PTEN
organic substance metabolic process (GO:0071704) 0.634MSH6, MSH3, MLH3, PTEN
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.434MSH6, MSH3, PTEN, CDH1
regulation of cellular metabolic process (GO:0031323) 1.074MSH6, MSH3, PTEN, CDH1
cellular metabolic process (GO:0044237) 0.694MSH6, MSH3, MLH3, PTEN
regulation of cellular process (GO:0050794) 0.54MSH6, MSH3, PTEN, CDH1
metabolic process (GO:0008152) 0.584MSH6, MSH3, MLH3, PTEN
reproductive process (GO:0022414) 2.554MSH6, MSH3, MLH3, PTEN
response to stress (GO:0006950) 1.84MSH6, MSH3, MLH3, PTEN
biological regulation (GO:0065007) 0.394MSH6, MSH3, PTEN, CDH1
regulation of nitrogen compound metabolic process (GO:0051171) 1.364MSH6, MSH3, PTEN, CDH1
cellular response to stress (GO:0033554) 2.514MSH6, MSH3, MLH3, PTEN
regulation of macromolecule metabolic process (GO:0060255) 1.084MSH6, MSH3, PTEN, CDH1
negative regulation of biological process (GO:0048519) 1.334MSH6, MSH3, PTEN, CDH1
macromolecule metabolic process (GO:0043170) 0.834MSH6, MSH3, MLH3, PTEN
regulation of biological process (GO:0050789) 0.454MSH6, MSH3, PTEN, CDH1
negative regulation of cellular process (GO:0048523) 1.414MSH6, MSH3, PTEN, CDH1
regulation of primary metabolic process (GO:0080090) 1.084MSH6, MSH3, PTEN, CDH1
cellular component assembly (GO:0022607) 2.143MLH3, PTEN, CDH1
negative regulation of metabolic process (GO:0009892) 1.933MSH3, MSH6, PTEN
positive regulation of metabolic process (GO:0009893) 1.743MSH6, PTEN, CDH1
positive regulation of cellular metabolic process (GO:0031325) 1.813MSH6, PTEN, CDH1
negative regulation of cellular metabolic process (GO:0031324) 2.013MSH3, MSH6, PTEN
mismatch repair (GO:0006298) 6.233MSH3, MSH6, MLH3
meiotic cell cycle process (GO:1903046) 4.713MSH3, MSH6, MLH3
nucleic acid metabolic process (GO:0090304) 1.463MSH3, MSH6, MLH3
cellular nitrogen compound metabolic process (GO:0034641) 1.223MSH3, MSH6, MLH3
nitrogen compound metabolic process (GO:0006807) 1.133MSH3, MSH6, MLH3
cell cycle process (GO:0022402) 2.753MSH3, MSH6, MLH3
single-organism process (GO:0044699) 0.483MSH6, PTEN, CDH1
nucleobase-containing compound metabolic process (GO:0006139) 1.353MSH3, MSH6, MLH3
negative regulation of macromolecule metabolic process (GO:0010605) 2.013MSH3, MSH6, PTEN
positive regulation of macromolecule metabolic process (GO:0010604) 1.813MSH6, PTEN, CDH1
organic cyclic compound metabolic process (GO:1901360) 1.263MSH3, MSH6, MLH3
positive regulation of molecular function (GO:0044093) 2.233MSH3, MSH6, PTEN
positive regulation of biological process (GO:0048518) 1.23MSH6, PTEN, CDH1
regulation of molecular function (GO:0065009) 1.783MSH3, MSH6, PTEN
positive regulation of catalytic activity (GO:0043085) 2.43MSH3, MSH6, PTEN
DNA repair (GO:0006281) 3.593MSH3, MSH6, MLH3
regulation of catalytic activity (GO:0050790) 1.973MSH3, MSH6, PTEN
cellular aromatic compound metabolic process (GO:0006725) 1.33MSH3, MSH6, MLH3
cellular response to DNA damage stimulus (GO:0006974) 3.173MSH3, MSH6, MLH3
single-organism cellular process (GO:0044763) 0.653MSH6, PTEN, CDH1
reciprocal meiotic recombination (GO:0007131) 6.333MSH3, MSH6, MLH3
heterocycle metabolic process (GO:0046483) 1.313MSH3, MSH6, MLH3
DNA recombination (GO:0006310) 4.393MSH3, MSH6, MLH3
chromosome organization (GO:0051276) 3.793MSH3, MSH6, MLH3
DNA metabolic process (GO:0006259) 3.093MSH3, MSH6, MLH3
reciprocal DNA recombination (GO:0035825) 6.333MSH3, MSH6, MLH3
positive regulation of cellular process (GO:0048522) 1.33MSH6, PTEN, CDH1
protein localization (GO:0008104) 2.362MLH3, CDH1
regulation of multicellular organismal process (GO:0051239) 1.872MSH6, PTEN
regulation of cellular localization (GO:0060341) 3.032PTEN, CDH1
cell projection organization (GO:0030030) 3.142PTEN, CDH1
regulation of transport (GO:0051049) 2.242PTEN, CDH1
regulation of cell adhesion (GO:0030155) 3.272PTEN, CDH1
positive regulation of response to stimulus (GO:0048584) 2.182MSH6, PTEN
regulation of response to stimulus (GO:0048583) 1.542MSH6, PTEN
positive regulation of immune response (GO:0050778) 3.42MSH6, PTEN
membrane organization (GO:0061024) 3.042PTEN, CDH1
plasma membrane organization (GO:0007009) 4.82PTEN, CDH1
synapse organization (GO:0050808) 4.872PTEN, CDH1
signal transduction (GO:0007165) 1.282MSH6, PTEN
cellular response to chemical stimulus (GO:0070887) 2.572PTEN, CDH1
neuron projection development (GO:0031175) 4.582PTEN, CDH1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352MSH6, CDH1
intracellular signal transduction (GO:0035556) 2.392MSH6, PTEN
synapse assembly (GO:0007416) 5.552PTEN, CDH1
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.552MSH3, MSH6
response to endogenous stimulus (GO:0009719) 2.792PTEN, CDH1
single-organism metabolic process (GO:0044710) 1.632MSH6, PTEN
maintenance of DNA repeat elements (GO:0043570) 8.122MSH3, MSH6
positive regulation of hydrolase activity (GO:0051345) 2.912MSH3, MSH6
response to nitrogen compound (GO:1901698) 3.122PTEN, CDH1
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462PTEN, CDH1
localization (GO:0051179) 1.42MLH3, CDH1
positive regulation of immune system process (GO:0002684) 2.962MSH6, PTEN
animal organ development (GO:0048513) 2.532PTEN, CDH1
regulation of immune system process (GO:0002682) 2.52MSH6, PTEN
response to organic cyclic compound (GO:0014070) 3.072PTEN, CDH1
regulation of localization (GO:0032879) 1.942PTEN, CDH1
regulation of cellular biosynthetic process (GO:0031326) 1.382PTEN, CDH1
macromolecule localization (GO:0033036) 2.342MLH3, CDH1
regulation of gene expression (GO:0010468) 1.372PTEN, CDH1
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472MSH3, MSH6
developmental process (GO:0032502) 1.362PTEN, CDH1
regulation of hydrolase activity (GO:0051336) 2.532MSH3, MSH6
multicellular organismal process (GO:0032501) 1.452MSH6, PTEN
negative regulation of DNA metabolic process (GO:0051053) 4.982MSH3, MSH6
regulation of DNA metabolic process (GO:0051052) 3.872MSH3, MSH6
regulation of developmental process (GO:0050793) 2.12MSH6, PTEN
regulation of immune response (GO:0050776) 2.982MSH6, PTEN
regulation of biosynthetic process (GO:0009889) 1.372PTEN, CDH1
regulation of nucleic acid-templated transcription (GO:1903506) 1.552PTEN, CDH1
single-organism developmental process (GO:0044767) 1.492PTEN, CDH1
negative regulation of cell adhesion (GO:0007162) 4.332PTEN, CDH1
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292MSH6, CDH1
response to metal ion (GO:0010038) 3.912PTEN, CDH1
regulation of RNA biosynthetic process (GO:2001141) 1.552PTEN, CDH1
response to chemical (GO:0042221) 1.982PTEN, CDH1
response to inorganic substance (GO:0010035) 3.562PTEN, CDH1
response to organic substance (GO:0010033) 2.22PTEN, CDH1
multi-organism process (GO:0051704) 2.652MSH6, PTEN
response to oxygen-containing compound (GO:1901700) 2.572PTEN, CDH1
response to abiotic stimulus (GO:0009628) 2.82MSH6, PTEN
negative regulation of DNA recombination (GO:0045910) 6.962MSH3, MSH6
positive regulation of helicase activity (GO:0051096) 7.942MSH3, MSH6
single-multicellular organism process (GO:0044707) 1.782MSH6, PTEN
meiotic mismatch repair (GO:0000710) 8.122MSH3, MSH6
anatomical structure development (GO:0048856) 1.582PTEN, CDH1
response to drug (GO:0042493) 3.712PTEN, CDH1
regulation of DNA recombination (GO:0000018) 5.652MSH3, MSH6
immune system process (GO:0002376) 2.292MSH6, PTEN
regulation of transcription, DNA-templated (GO:0006355) 1.562PTEN, CDH1
regulation of macromolecule biosynthetic process (GO:0010556) 1.432PTEN, CDH1
regulation of multicellular organismal development (GO:2000026) 2.312MSH6, PTEN
regulation of helicase activity (GO:0051095) 7.532MSH3, MSH6
single-organism membrane organization (GO:0044802) 3.192PTEN, CDH1
regulation of RNA metabolic process (GO:0051252) 1.522PTEN, CDH1
response to alcohol (GO:0097305) 4.582PTEN, CDH1
response to organonitrogen compound (GO:0010243) 3.22PTEN, CDH1

NET-GE enrichment

Term New enriched termICP valueGenes
organophosphate catabolic process (GO:0046434) NEW5.030.008MSH6, MLH3, MSH3, PTEN, CDH1
nucleoside triphosphate metabolic process (GO:0009141) NEW4.610.018MSH6, MLH3, MSH3, PTEN, CDH1
nucleoside triphosphate catabolic process (GO:0009143) NEW7.240.009MSH6, MLH3, MSH3, PTEN, CDH1
purine nucleoside triphosphate metabolic process (GO:0009144) NEW4.760.015MSH6, MLH3, MSH3, PTEN, CDH1
mismatch repair (GO:0006298) -6.230.0MSH3, MSH6, MLH3
purine nucleoside triphosphate catabolic process (GO:0009146) NEW7.940.009MSH6, MLH3, MSH3, PTEN, CDH1
meiotic cell cycle process (GO:1903046) -4.710.001MSH6, MSH3, MLH3, PTEN
nucleotide catabolic process (GO:0009166) NEW5.670.014MSH6, MLH3, MSH3, PTEN, CDH1
nucleoside catabolic process (GO:0009164) NEW6.170.013MSH6, MLH3, MSH3, PTEN, CDH1
cell cycle process (GO:0022402) -2.750.029MSH6, MSH3, MLH3, PTEN
negative regulation of DNA metabolic process (GO:0051053) -4.980.024MSH3, MSH6, CDH1
female meiosis I (GO:0007144) NEW8.340.004MSH6, MLH3
purine nucleotide catabolic process (GO:0006195) NEW6.070.012MSH6, MLH3, MSH3, PTEN, CDH1
purine ribonucleoside catabolic process (GO:0046130) NEW7.160.01MSH6, MLH3, MSH3, PTEN, CDH1
ribonucleotide metabolic process (GO:0009259) NEW4.110.041MSH6, MLH3, MSH3, PTEN, CDH1
ribonucleoside metabolic process (GO:0009119) NEW4.210.034MSH6, MLH3, MSH3, PTEN, CDH1
nucleoside monophosphate catabolic process (GO:0009125) NEW7.650.049MSH6, MSH3, MLH3, PTEN
purine-containing compound catabolic process (GO:0072523) NEW5.920.013MSH6, MLH3, MSH3, PTEN, CDH1
DNA repair (GO:0006281) -3.590.04MSH6, MSH3, MLH3, PTEN
purine nucleoside metabolic process (GO:0042278) NEW4.320.029MSH6, MLH3, MSH3, PTEN, CDH1
ribonucleoside triphosphate metabolic process (GO:0009199) NEW4.770.016MSH6, MLH3, MSH3, PTEN, CDH1
purine nucleoside catabolic process (GO:0006152) NEW7.160.01MSH6, MLH3, MSH3, PTEN, CDH1
somatic diversification of immune receptors (GO:0002200) NEW5.920.027MSH3, MSH6
negative regulation of DNA recombination (GO:0045910) -6.960.004MSH3, MSH6
purine ribonucleoside triphosphate catabolic process (GO:0009207) NEW9.730.009MSH6, MLH3, MSH3, PTEN, CDH1
purine ribonucleoside triphosphate metabolic process (GO:0009205) NEW4.810.015MSH6, MLH3, MSH3, PTEN, CDH1
purine ribonucleotide catabolic process (GO:0009154) NEW6.470.011MSH6, MLH3, MSH3, PTEN, CDH1
ribonucleoside triphosphate catabolic process (GO:0009203) NEW9.730.009MSH6, MLH3, MSH3, PTEN, CDH1
regulation of DNA metabolic process (GO:0051052) -3.870.037MSH6, MSH3, PTEN, CDH1
ribonucleoside monophosphate catabolic process (GO:0009158) NEW8.120.047MSH6, MSH3, MLH3, PTEN
purine ribonucleoside monophosphate catabolic process (GO:0009169) NEW8.120.047MSH6, MSH3, MLH3, PTEN
purine ribonucleotide metabolic process (GO:0009150) NEW4.160.037MSH6, MLH3, MSH3, PTEN, CDH1
cellular response to DNA damage stimulus (GO:0006974) -3.170.008MSH6, MLH3, MSH3, PTEN, CDH1
nucleoside metabolic process (GO:0009116) NEW4.120.039MSH6, MLH3, MSH3, PTEN, CDH1
reciprocal meiotic recombination (GO:0007131) -6.330.001MSH3, MSH6, MLH3
purine ribonucleoside metabolic process (GO:0046128) NEW4.330.028MSH6, MLH3, MSH3, PTEN, CDH1
ribonucleoside catabolic process (GO:0042454) NEW6.550.011MSH6, MLH3, MSH3, PTEN, CDH1
DNA recombination (GO:0006310) -4.390.009MSH3, MSH6, MLH3
ribonucleotide catabolic process (GO:0009261) NEW6.430.011MSH6, MLH3, MSH3, PTEN, CDH1
somatic diversification of immune receptors via germline recombination within a single locus (GO:0002562) NEW6.230.023MSH3, MSH6
positive regulation of helicase activity (GO:0051096) -7.940.004MSH3, MSH6
regulation of helicase activity (GO:0051095) -7.530.002MSH3, MSH6
positive regulation of DNA-dependent DNA replication (GO:2000105) NEW7.160.029PTEN, CDH1
carbohydrate derivative catabolic process (GO:1901136) NEW4.610.036MSH6, MLH3, MSH3, PTEN, CDH1
meiotic mismatch repair (GO:0000710) -8.120.0MSH3, MSH6
purine nucleoside monophosphate catabolic process (GO:0009128) NEW7.940.048MSH6, MSH3, MLH3, PTEN
ribose phosphate metabolic process (GO:0019693) NEW4.060.042MSH6, MLH3, MSH3, PTEN, CDH1
purine nucleotide metabolic process (GO:0006163) NEW4.090.041MSH6, MLH3, MSH3, PTEN, CDH1
glycosyl compound metabolic process (GO:1901657) NEW4.040.044MSH6, MLH3, MSH3, PTEN, CDH1
nucleoside phosphate catabolic process (GO:1901292) NEW5.540.015MSH6, MLH3, MSH3, PTEN, CDH1
somatic recombination of immunoglobulin gene segments (GO:0016447) NEW6.680.011MSH3, MSH6
reciprocal DNA recombination (GO:0035825) -6.330.001MSH3, MSH6, MLH3
somatic diversification of immunoglobulins (GO:0016445) NEW6.260.014MSH3, MSH6
somatic cell DNA recombination (GO:0016444) NEW6.230.023MSH3, MSH6
glycosyl compound catabolic process (GO:1901658) NEW6.020.013MSH6, MLH3, MSH3, PTEN, CDH1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.115MSH6, MLH3, MSH3, PTEN, CDH1
intracellular organelle part (GO:0044446) 0.815MSH6, MLH3, MSH3, PTEN, CDH1
intracellular organelle (GO:0043229) 0.515MSH6, MLH3, MSH3, PTEN, CDH1
intracellular part (GO:0044424) 0.285MSH6, MLH3, MSH3, PTEN, CDH1
organelle (GO:0043226) 0.45MSH6, MLH3, MSH3, PTEN, CDH1
organelle part (GO:0044422) 0.795MSH6, MLH3, MSH3, PTEN, CDH1
protein complex (GO:0043234) 1.514MSH6, MSH3, MLH3, CDH1
macromolecular complex (GO:0032991) 1.354MSH6, MSH3, MLH3, CDH1
intracellular membrane-bounded organelle (GO:0043231) 0.64MLH3, MSH6, PTEN, CDH1
intracellular non-membrane-bounded organelle (GO:0043232) 1.764MSH6, MSH3, MLH3, CDH1
membrane (GO:0016020) 0.684MSH6, MSH3, PTEN, CDH1
non-membrane-bounded organelle (GO:0043228) 1.764MSH6, MSH3, MLH3, CDH1
nuclear part (GO:0044428) 1.554MSH6, MSH3, MLH3, PTEN
membrane-bounded organelle (GO:0043227) 0.474MLH3, MSH6, PTEN, CDH1
cytoplasm (GO:0005737) 1.013MSH6, PTEN, CDH1
DNA repair complex (GO:1990391) 6.143MSH3, MSH6, MLH3
nucleus (GO:0005634) 1.073MSH6, MLH3, PTEN
nucleoplasm (GO:0005654) 1.893MSH3, MSH6, PTEN
cytoplasmic part (GO:0044444) 0.823MSH6, PTEN, CDH1
mismatch repair complex (GO:0032300) 7.033MSH3, MSH6, MLH3
plasma membrane (GO:0005886) 1.393MSH6, PTEN, CDH1
nuclear chromosome (GO:0000228) 5.553MSH3, MSH6, MLH3
chromosome (GO:0005694) 3.783MSH3, MSH6, MLH3
Golgi apparatus (GO:0005794) 2.72MSH6, CDH1
chromosomal part (GO:0044427) 3.182MSH6, MLH3
cytoplasmic side of membrane (GO:0098562) 5.812PTEN, CDH1
cytoplasmic side of plasma membrane (GO:0009898) 6.02PTEN, CDH1
nuclear chromosome part (GO:0044454) 3.672MSH6, MLH3
extracellular region (GO:0005576) 2.182PTEN, CDH1
side of membrane (GO:0098552) 4.222PTEN, CDH1
membrane part (GO:0044425) 0.952PTEN, CDH1
cell projection (GO:0042995) 2.472PTEN, CDH1
plasma membrane part (GO:0044459) 1.952PTEN, CDH1

NET-GE enrichment

Term New enriched termICP valueGenes
chromosomal part (GO:0044427) -3.180.046MLH3, MSH6, PTEN, CDH1
aggresome (GO:0016235) NEW6.250.009PTEN, CDH1
inclusion body (GO:0016234) NEW5.550.042PTEN, CDH1
condensed chromosome (GO:0000793) NEW5.640.047MSH6, PTEN
DNA repair complex (GO:1990391) -6.140.0MSH3, MSH6, MLH3
cytoplasmic side of membrane (GO:0098562) -5.810.005PTEN, CDH1
cytoplasmic side of plasma membrane (GO:0009898) -6.00.004PTEN, CDH1
nuclear chromosome part (GO:0044454) -3.670.004MLH3, MSH6, PTEN, CDH1
mismatch repair complex (GO:0032300) -7.030.0MSH3, MSH6, MLH3
synaptonemal complex (GO:0000795) NEW6.540.003MLH3, PTEN
nuclear chromosome (GO:0000228) -5.550.0MSH3, MSH6, PTEN
Schmidt-Lanterman incisure (GO:0043220) NEW7.320.0PTEN, CDH1
chromosome (GO:0005694) -3.780.019MSH3, MSH6, PTEN
male germ cell nucleus (GO:0001673) NEW6.970.0MSH6, MLH3, PTEN
germ cell nucleus (GO:0043073) NEW6.760.0MSH6, MLH3, PTEN