Disease table of MISMATCH REPAIR CANCER SYNDROME OMIM ID: 276300

Gene-disease associations table

GeneAssociated with MISMATCH REPAIR CANCER SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
MSH2ClinVar, OMIMHGNC link2p213276300, 158320, PS120435
PMS2ClinVar, OMIM, HUMSAVARHGNC link7p22.12276300, PS120435
MSH6ClinVar, OMIMHGNC link2p16.33276300, PS120435, 608089
MLH1ClinVar, OMIM, HUMSAVARHGNC link3p22.23276300, 158320, PS120435

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
2p2MSH6, MSH2
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
22MSH6, MSH2
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
MSH2YES2MBD2, DNMT10
MSH6YES1SP30
MLH1YES1CEBPZ0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
MSH2PMS2Yes7MSH6, MSH3, PCNA, MSH2, EXO1, BRCA1, MLH1
MSH2MSH6Yes45ATM, AIRE, FAF2, RAD9A, PRKCZ, XRCC6, TP53, DTL, RAD50, SIRT7, SMARCAD1, SNW1, ATR, CDC5L, FEN1, MSH2, BLM, RFC1, PMS1, PMS2, BRCA1, RAD21, MRE11A, NBN, ATP6V1B2, RAD1, CEP19, MUTYH, BARD1, RNF126, SUPT16H, RAD51, PCNA, SLX4, SIRT6, CREBBP, MSH3, SUPT5H, CHEK1, HUS1, XRCC5, NTRK1, MYC, MLH1, POLK
MSH2MLH1Yes20ATM, NBN, MSH3, PCNA, MYC, MRE11A, BARD1, PMS1, RFC1, MSH6, BLM, RAD50, PMS2, EXO1, NTRK1, SNW1, BRCA1, ANXA6, MSH2, FANCD2
PMS2MSH6Yes8MSH3, CLSPN, MSH2, PRKDC, TOPBP1, PCNA, BRCA1, MLH1
PMS2MLH1Yes20MSH3, ATAD3A, PCNA, PIK3C2A, MMS19, BRIP1, MSH2, PRKDC, RUVBL1, PSD3, RUVBL2, FAN1, EXO1, UBC, KPNA2, BRCA1, KPNB1, MSH6, SPRTN, AIFM1
MSH6MLH1Yes18ATM, NBN, MSH3, PRKDC, MSH2, BARD1, PMS1, RFC1, MYC, BLM, PMS2, MRE11A, SMC1A, PCNA, NTRK1, RAD50, SNW1, BRCA1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
MSH2PMS2Yesbinding21ERCC1, ERCC5, MSH3, FEN1, POLE, XPC, MLH1, XRCC6, RAD51, ERCC4, TP53, XPA, MLH3, EXO1, RECQL, UBC, MSH6, PCNA, WRN, XRCC5, POLD1
MSH2MSH6Yesbinding44ERCC5, POLE4, PCNA, CHEK1, POLE3, TP53, FANCM, RAD50, XPC, ERCC8, POLD1, ATR, RAD52, POLE, MLH1, RAD51, PMS1, SWSAP1, RECQL, BRCA1, RAD51D, ERCC1, RAD23B, MUTYH, BARD1, PMS2, ZSWIM7, ALDH18A1, XRCC6BP1, EXO1, RAD51B, CHRAC1, MSH3, XRCC5, WRN, XRCC4, XRCC6, ERCC4, BLM, MLH3, OGG1, UBC, POLE2, POLK
MSH2MLH1Yesbinding31ERCC5, PCNA, RAD9A, FANCD2, TP53, RAD50, XPC, XPA, POLD1, POLE, RAD51, RPA1, PMS1, RAD23B, BRCA1, ERCC1, DMC1, PMS2, WDTC1, EXO1, MSH6, RECQL, MSH3, FEN1, WRN, XRCC6, ERCC4, BLM, XRCC5, MYC, MLH3
PMS2MSH6Yesbinding19POLD1, ERCC1, MSH3, PCNA, WRN, MSH2, XRCC6, TP53, ERCC5, XRCC5, POLE, RAD51, EXO1, UBC, RECQL, ERCC4, MLH1, MLH3, XPC
PMS2MLH1Yesbinding24ERCC5, FBXO18, EXO1, TP53, XPC, XPA, POLD1, FEN1, MSH2, RAD51, MSH4, RECQL, ERCC1, PCNA, MSH6, BRIP1, FAN1, MSH3, POLE, WRN, XRCC6, ERCC4, XRCC5, MLH3
MSH6MLH1Yesbinding23ERCC5, PCNA, TP53, RAD50, POLD1, POLE, MSH2, PMS1, RAD23B, RECQL, ERCC1, PMS2, EXO1, XPC, BRCA1, MSH3, XRCC5, WRN, XRCC6, ERCC4, BLM, MLH3, RAD51

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
MSH2PMS2YesMSH2-MSH6-PMS2-MLH1 complex;MSH2-MLH1-PMS2 DNA-repair initiation complex;PCNA-MutS-alpha-MutL-alpha-DNA complex;MSH2-MLH1-PMS2-PCNA DNA-repair initiation complex3MSH6, MLH1, PCNA
MSH2MSH6YesMSH2-MSH6-PMS2-MLH1 complex;MSH2-MSH6-PMS1-MLH1 complex;BASC (Ab 80) complex (BRCA1-associated genome surveillance complex);PCNA-MutS-alpha-DNA initial complex;GCN5-TRRAP histone acetyltransferase complex;MutS-alpha-PK-zeta complex;PCNA-MSH2-MSH6 complex;BASC complex (BRCA1-associated genome surveillance complex);MutS-alpha complex;MSH2/6-BLM-p53-RAD51 complex;PCNA-MutS-alpha-MutL-alpha-DNA complex;MSH2-MSH6 complex23ATM, KAT2A, TAF10, TAF5L, TP53, TRRAP, RAD50, SUPT3H, MLH1, RFC1, PMS1, BRCA1, NBN, TADA3, MRE11A, PCNA, RFC2, PMS2, PRKCZ, TAF9, BLM, RFC4, RAD51
MSH2MLH1YesMSH2-MSH6-PMS2-MLH1 complex;MSH2-MSH6-PMS1-MLH1 complex;BASC (Ab 80) complex (BRCA1-associated genome surveillance complex);MSH2-MLH1-PMS2 DNA-repair initiation complex;MSH2-MLH1-PMS2-PCNA DNA-repair initiation complex;BASC complex (BRCA1-associated genome surveillance complex);PCNA-MutS-alpha-MutL-alpha-DNA complex13ATM, NBN, PMS2, RFC2, PCNA, MRE11A, PMS1, RFC1, BLM, RAD50, RFC4, BRCA1, MSH6
PMS2MSH6YesMSH2-MSH6-PMS2-MLH1 complex;PCNA-MutS-alpha-MutL-alpha-DNA complex3MSH2, MLH1, PCNA
PMS2MLH1YesMSH2-MSH6-PMS2-MLH1 complex;MSH2-MLH1-PMS2 DNA-repair initiation complex;EXO1-MLH1-PMS2 complex;MSH2-MLH1-PMS2-PCNA DNA-repair initiation complex;MutL-alpha complex;PCNA-MutS-alpha-MutL-alpha-DNA complex4MSH6, MSH2, EXO1, PCNA
MSH6MLH1YesMSH2-MSH6-PMS2-MLH1 complex;MSH2-MSH6-PMS1-MLH1 complex;BASC (Ab 80) complex (BRCA1-associated genome surveillance complex);BASC complex (BRCA1-associated genome surveillance complex);BRCA1-BARD1-BACH1-DNA damage complex I;PCNA-MutS-alpha-MutL-alpha-DNA complex16ATM, NBN, TOPBP1, RFC2, PCNA, BACH1, MRE11A, BARD1, PMS1, RFC1, BLM, RAD50, PMS2, RFC4, BRCA1, MSH2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
MSH2MSH6Yes2MSH3, SUPT16H
PMS2MLH1Yes0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
MSH2MSH6Yes2MSH2, MSH6

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Mismatch repairhsa034308.074MSH6, MSH2, PMS2, MLH1
Colorectal cancerhsa052106.523MSH2, MSH6, MLH1
Pathways in cancerhsa052003.983MSH2, MSH6, MLH1
Fanconi anemia pathwayhsa034607.012PMS2, MLH1

NET-GE enrichment

Term New enriched termICP valueGenes
Cancers: Specific typesNEW4.10.008MSH2, MSH6, MLH1
Genetic Information ProcessingNEW2.480.011MSH6, MSH2, PMS2, MLH1
Colorectal cancer (hsa05210) -6.520.0MSH2, MSH6, MLH1
Pathways in cancer (hsa05200) -3.980.011MSH6, MSH2, MLH1
Mismatch repair (hsa03430) -8.070.0MSH6, MSH2, PMS2, MLH1
Replication and repairNEW5.410.0MSH6, PMS2, MSH2, MLH1
Fanconi anemia pathway (hsa03460) -7.010.0MSH6, MSH2, PMS2, MLH1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
DNA RepairR-HSA-738945.84MSH6, MSH2, PMS2, MLH1
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)R-HSA-53585659.184MSH6, MSH2, PMS2, MLH1
Mismatch RepairR-HSA-53585089.084MSH6, MSH2, PMS2, MLH1
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)R-HSA-53586069.183MSH2, PMS2, MLH1

NET-GE enrichment

Term New enriched termICP valueGenes
DNA Repair (R-HSA-73894) -5.80.0MSH6, MSH2, PMS2, MLH1
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (R-HSA-5358565) -9.180.0MSH6, MSH2, PMS2, MLH1
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (R-HSA-5358606) -9.180.0MSH2, PMS2, MLH1
Mismatch Repair (R-HSA-5358508) -9.080.0MSH6, MSH2, PMS2, MLH1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
nucleic acid binding (GO:0003676) 1.444MSH6, MSH2, PMS2, MLH1
purine ribonucleoside triphosphate binding (GO:0035639) 2.224MSH6, MSH2, PMS2, MLH1
mismatched DNA binding (GO:0030983) 7.254MSH6, MSH2, PMS2, MLH1
macromolecular complex binding (GO:0044877) 2.614MSH6, MSH2, PMS2, MLH1
binding (GO:0005488) 0.184MSH6, MSH2, PMS2, MLH1
ATPase activity (GO:0016887) 3.654MSH6, PMS2, MSH2, MLH1
DNA binding (GO:0003677) 1.924MSH6, MSH2, PMS2, MLH1
heterocyclic compound binding (GO:1901363) 1.064MSH6, MSH2, PMS2, MLH1
nucleoside phosphate binding (GO:1901265) 1.964MSH6, MSH2, PMS2, MLH1
nucleoside binding (GO:0001882) 2.214MSH6, PMS2, MSH2, MLH1
nucleotide binding (GO:0000166) 1.964MSH6, MSH2, PMS2, MLH1
purine nucleoside binding (GO:0001883) 2.224MSH6, MSH2, PMS2, MLH1
ribonucleoside binding (GO:0032549) 2.224MSH6, PMS2, MSH2, MLH1
protein complex binding (GO:0032403) 3.094MSH6, MSH2, PMS2, MLH1
purine nucleotide binding (GO:0017076) 2.194MSH6, MSH2, PMS2, MLH1
double-stranded DNA binding (GO:0003690) 3.094MSH6, MSH2, PMS2, MLH1
ATP binding (GO:0005524) 2.434MSH6, MSH2, PMS2, MLH1
mismatch repair complex binding (GO:0032404) 7.664MSH6, MSH2, PMS2, MLH1
hydrolase activity (GO:0016787) 1.94MSH6, MSH2, PMS2, MLH1
nucleoside-triphosphatase activity (GO:0017111) 3.094MSH6, MSH2, PMS2, MLH1
small molecule binding (GO:0036094) 1.894MSH6, MSH2, PMS2, MLH1
catalytic activity (GO:0003824) 1.054MSH6, MSH2, PMS2, MLH1
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 3.034MSH6, MSH2, PMS2, MLH1
adenyl nucleotide binding (GO:0030554) 2.44MSH6, MSH2, PMS2, MLH1
carbohydrate derivative binding (GO:0097367) 2.034MSH6, MSH2, PMS2, MLH1
organic cyclic compound binding (GO:0097159) 1.054MSH6, MSH2, PMS2, MLH1
hydrolase activity, acting on acid anhydrides (GO:0016817) 3.034MSH6, MSH2, PMS2, MLH1
pyrophosphatase activity (GO:0016462) 3.044MSH6, MSH2, PMS2, MLH1
adenyl ribonucleotide binding (GO:0032559) 2.414MSH6, MSH2, PMS2, MLH1
protein binding (GO:0005515) 0.464MSH6, MSH2, PMS2, MLH1
purine ribonucleotide binding (GO:0032555) 2.24MSH6, MSH2, PMS2, MLH1
purine ribonucleoside binding (GO:0032550) 2.224MSH6, MSH2, PMS2, MLH1
ribonucleotide binding (GO:0032553) 2.194MSH6, MSH2, PMS2, MLH1
guanine/thymine mispair binding (GO:0032137) 8.353MSH2, MSH6, MLH1
DNA insertion or deletion binding (GO:0032135) 7.953MSH6, MSH2, PMS2
single-stranded DNA binding (GO:0003697) 5.173MSH2, PMS2, MLH1
single base insertion or deletion binding (GO:0032138) 8.353MSH6, PMS2, MSH2
oxidized purine DNA binding (GO:0032357) 8.132MSH2, MSH6
oxidized DNA binding (GO:0032356) 8.132MSH2, MSH6
structure-specific DNA binding (GO:0043566) 4.982MSH2, MSH6
chromatin binding (GO:0003682) 3.642MLH1, MSH6
cation binding (GO:0043169) 1.42MSH2, MSH6
single guanine insertion binding (GO:0032142) 8.642MSH2, MSH6
single thymine insertion binding (GO:0032143) 9.052MSH2, MSH6
magnesium ion binding (GO:0000287) 4.412MSH2, MSH6
DNA secondary structure binding (GO:0000217) 6.62MSH2, MSH6
four-way junction DNA binding (GO:0000400) 7.032MSH2, MSH6
ion binding (GO:0043167) 1.362MSH2, MSH6
identical protein binding (GO:0042802) 2.632MSH2, MSH6
ADP binding (GO:0043531) 6.242MSH2, MSH6
protein dimerization activity (GO:0046983) 2.722MSH2, MSH6
metal ion binding (GO:0046872) 1.412MSH2, MSH6
MutSalpha complex binding (GO:0032407) 8.132PMS2, MLH1
damaged DNA binding (GO:0003684) 5.582MSH2, MSH6
MutLalpha complex binding (GO:0032405) 7.952MSH2, MSH6
protein homodimerization activity (GO:0042803) 3.162MSH2, MSH6

NET-GE enrichment

Term New enriched termICP valueGenes
DNA-dependent ATPase activity (GO:0008094) NEW5.310.005MSH6, PMS2, MSH2
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) -3.030.0MSH6, PMS2, MSH2, MLH1
DNA insertion or deletion binding (GO:0032135) -7.950.0PMS2, MSH2
ATPase activity, coupled (GO:0042623) NEW3.970.0MSH6, PMS2, MSH2, MLH1
hydrolase activity (GO:0016787) -1.90.028MSH6, PMS2, MSH2, MLH1
deoxyribonuclease activity (GO:0004536) NEW5.480.027MSH2, MLH1
nucleoside-triphosphatase activity (GO:0017111) -3.090.0MSH6, PMS2, MSH2, MLH1
kinase activity (GO:0016301) NEW2.930.027MSH6, MSH2, PMS2, MLH1
structure-specific DNA binding (GO:0043566) -4.980.0MSH6, PMS2, MSH2, MLH1
hydrolase activity, acting on acid anhydrides (GO:0016817) -3.030.015MSH6, MSH2, PMS2, MLH1
mismatched DNA binding (GO:0030983) -7.250.0MSH6, MSH2, PMS2, MLH1
pyrophosphatase activity (GO:0016462) -3.040.015MSH6, PMS2, MSH2, MLH1
single-stranded DNA binding (GO:0003697) -5.170.038MSH6, MLH1
ATPase activity (GO:0016887) -3.650.0MSH6, MSH2, PMS2, MLH1
DNA binding (GO:0003677) -1.920.022MSH6, MSH2, PMS2, MLH1
guanine/thymine mispair binding (GO:0032137) -8.350.0MSH6, MSH2, MLH1
double-stranded DNA binding (GO:0003690) -3.090.0MSH6, MSH2, PMS2, MLH1
damaged DNA binding (GO:0003684) -5.580.009MSH2, MSH6
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
mismatch repair (GO:0006298) 6.234MSH6, MSH2, PMS2, MLH1
nucleic acid metabolic process (GO:0090304) 1.464MSH6, MSH2, PMS2, MLH1
cellular nitrogen compound metabolic process (GO:0034641) 1.224MSH6, MSH2, PMS2, MLH1
nitrogen compound metabolic process (GO:0006807) 1.134MSH6, PMS2, MSH2, MLH1
organic cyclic compound metabolic process (GO:1901360) 1.264MSH6, MSH2, PMS2, MLH1
nucleobase-containing compound metabolic process (GO:0006139) 1.354MSH6, MSH2, PMS2, MLH1
cellular response to stimulus (GO:0051716) 1.974MSH6, MSH2, PMS2, MLH1
cellular macromolecule metabolic process (GO:0044260) 0.934MSH6, MSH2, PMS2, MLH1
organic substance metabolic process (GO:0071704) 0.634MSH6, MSH2, PMS2, MLH1
somatic diversification of immune receptors (GO:0002200) 5.924MSH6, MSH2, PMS2, MLH1
DNA repair (GO:0006281) 3.594MSH6, MSH2, PMS2, MLH1
cellular process (GO:0009987) 0.264MSH6, MSH2, PMS2, MLH1
cellular aromatic compound metabolic process (GO:0006725) 1.34MSH6, MSH2, PMS2, MLH1
cellular response to DNA damage stimulus (GO:0006974) 3.174MSH6, MSH2, PMS2, MLH1
response to stress (GO:0006950) 1.84MSH6, MSH2, PMS2, MLH1
metabolic process (GO:0008152) 0.584MSH6, MSH2, PMS2, MLH1
heterocycle metabolic process (GO:0046483) 1.314MSH6, MSH2, PMS2, MLH1
primary metabolic process (GO:0044238) 0.694MSH6, MSH2, PMS2, MLH1
somatic diversification of immune receptors via somatic mutation (GO:0002566) 6.844MSH6, MSH2, PMS2, MLH1
response to stimulus (GO:0050896) 1.224MSH6, MSH2, PMS2, MLH1
cellular metabolic process (GO:0044237) 0.694MSH6, MSH2, PMS2, MLH1
macromolecule metabolic process (GO:0043170) 0.834MSH6, MSH2, PMS2, MLH1
immune system process (GO:0002376) 2.294MSH6, MSH2, PMS2, MLH1
cellular response to stress (GO:0033554) 2.514MSH6, PMS2, MSH2, MLH1
DNA metabolic process (GO:0006259) 3.094MSH6, MSH2, PMS2, MLH1
somatic diversification of immunoglobulins (GO:0016445) 6.264MSH6, MSH2, PMS2, MLH1
somatic hypermutation of immunoglobulin genes (GO:0016446) 6.94MSH6, PMS2, MSH2, MLH1
negative regulation of metabolic process (GO:0009892) 1.933MSH6, MSH2, MLH1
regulation of primary metabolic process (GO:0080090) 1.083MSH2, MSH6, MLH1
regulation of metabolic process (GO:0019222) 1.023MSH6, MSH2, MLH1
isotype switching (GO:0045190) 6.963MSH2, MSH6, MLH1
regulation of cellular metabolic process (GO:0031323) 1.073MSH2, MSH6, MLH1
B cell activation (GO:0042113) 4.843MSH2, MSH6, MLH1
intrinsic apoptotic signaling pathway (GO:0097193) 4.693MSH2, MSH6, MLH1
leukocyte activation (GO:0045321) 3.763MSH6, MSH2, MLH1
cell cycle process (GO:0022402) 2.753MSH6, MSH2, MLH1
signal transduction (GO:0007165) 1.283MSH6, MSH2, MLH1
negative regulation of cellular process (GO:0048523) 1.413MSH2, MSH6, MLH1
intracellular signal transduction (GO:0035556) 2.393MSH2, MSH6, MLH1
regulation of biological process (GO:0050789) 0.453MSH6, MSH2, MLH1
cellular component organization or biogenesis (GO:0071840) 1.223MSH6, MSH2, MLH1
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.553MSH2, MSH6, MLH1
single-organism metabolic process (GO:0044710) 1.633MSH2, MSH6, MLH1
negative regulation of macromolecule metabolic process (GO:0010605) 2.013MSH2, MSH6, MLH1
lymphocyte activation involved in immune response (GO:0002285) 5.223MSH2, MSH6, MLH1
cell activation involved in immune response (GO:0002263) 4.863MSH2, MSH6, MLH1
cellular component organization (GO:0016043) 1.243MSH6, MSH2, MLH1
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433MSH2, MSH6, MLH1
somatic diversification of immunoglobulins involved in immune response (GO:0002208) 6.963MSH6, MSH2, MLH1
leukocyte activation involved in immune response (GO:0002366) 4.883MSH2, MSH6, MLH1
biological regulation (GO:0065007) 0.393MSH2, MSH6, MLH1
single-organism process (GO:0044699) 0.483MSH2, MSH6, MLH1
negative regulation of biological process (GO:0048519) 1.333MSH6, MSH2, MLH1
negative regulation of DNA recombination (GO:0045910) 6.963MSH2, MSH6, MLH1
somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) 6.963MSH2, MSH6, MLH1
DNA recombination (GO:0006310) 4.393MSH6, MSH2, MLH1
negative regulation of cellular metabolic process (GO:0031324) 2.013MSH2, MSH6, MLH1
negative regulation of DNA metabolic process (GO:0051053) 4.983MSH6, MSH2, MLH1
regulation of DNA metabolic process (GO:0051052) 3.873MSH2, MSH6, MLH1
regulation of macromolecule metabolic process (GO:0060255) 1.083MSH2, MSH6, MLH1
apoptotic signaling pathway (GO:0097190) 4.123MSH6, MSH2, MLH1
regulation of cellular process (GO:0050794) 0.53MSH2, MSH6, MLH1
reproductive process (GO:0022414) 2.553MSH2, MSH6, MLH1
cell activation (GO:0001775) 3.473MSH2, MSH6, MLH1
lymphocyte activation (GO:0046649) 3.963MSH2, MSH6, MLH1
single-organism cellular process (GO:0044763) 0.653MSH6, MSH2, MLH1
regulation of nitrogen compound metabolic process (GO:0051171) 1.363MSH6, MSH2, MLH1
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.473MSH2, MSH6, MLH1
reciprocal meiotic recombination (GO:0007131) 6.333MSH6, MSH2, MLH1
meiotic cell cycle process (GO:1903046) 4.713MSH2, MSH6, MLH1
chromosome organization (GO:0051276) 3.793MSH6, MSH2, MLH1
organelle organization (GO:0006996) 2.023MSH2, MSH6, MLH1
somatic diversification of immune receptors via germline recombination within a single locus (GO:0002562) 6.233MSH6, MSH2, MLH1
intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630) 5.443MSH2, MSH6, MLH1
regulation of DNA recombination (GO:0000018) 5.653MSH6, MSH2, MLH1
B cell activation involved in immune response (GO:0002312) 6.173MSH2, MSH6, MLH1
immune effector process (GO:0002252) 3.583MSH2, MSH6, MLH1
reciprocal DNA recombination (GO:0035825) 6.333MSH2, MSH6, MLH1
somatic cell DNA recombination (GO:0016444) 6.233MSH6, MSH2, MLH1
somatic recombination of immunoglobulin gene segments (GO:0016447) 6.683MSH6, MSH2, MLH1
response to radiation (GO:0009314) 3.692MSH2, MSH6
cell development (GO:0048468) 3.282MSH2, MLH1
response to UV (GO:0009411) 4.882MSH2, MSH6
response to light stimulus (GO:0009416) 4.082MSH2, MSH6
positive regulation of catalytic activity (GO:0043085) 2.42MSH2, MSH6
double-strand break repair (GO:0006302) 4.732MSH2, MLH1
positive regulation of hydrolase activity (GO:0051345) 2.912MSH2, MSH6
cellular developmental process (GO:0048869) 1.822MSH2, MLH1
positive regulation of molecular function (GO:0044093) 2.232MSH2, MSH6
regulation of molecular function (GO:0065009) 1.782MSH2, MSH6
developmental process (GO:0032502) 1.362MSH2, MLH1
multicellular organismal process (GO:0032501) 1.452MSH2, MSH6
regulation of catalytic activity (GO:0050790) 1.972MSH2, MSH6
germ cell development (GO:0007281) 4.752MSH2, MLH1
developmental process involved in reproduction (GO:0003006) 3.362MSH2, MLH1
cellular process involved in reproduction in multicellular organism (GO:0022412) 4.32MSH2, MLH1
determination of adult lifespan (GO:0008340) 7.092MSH2, MSH6
maintenance of DNA repeat elements (GO:0043570) 8.122MSH2, MSH6
regulation of hydrolase activity (GO:0051336) 2.532MSH2, MSH6
response to abiotic stimulus (GO:0009628) 2.82MSH2, MSH6
single organism reproductive process (GO:0044702) 2.732MSH2, MLH1
positive regulation of helicase activity (GO:0051096) 7.942MSH2, MSH6
single-multicellular organism process (GO:0044707) 1.782MSH2, MSH6
meiotic mismatch repair (GO:0000710) 8.122MSH2, MSH6
anatomical structure development (GO:0048856) 1.582MSH2, MLH1
single-organism developmental process (GO:0044767) 1.492MSH2, MLH1
regulation of helicase activity (GO:0051095) 7.532MSH2, MSH6

NET-GE enrichment

Term New enriched termICP valueGenes
organophosphate catabolic process (GO:0046434) NEW5.030.001MSH6, MSH2, PMS2, MLH1
nucleotide catabolic process (GO:0009166) NEW5.670.0MSH6, MSH2, PMS2, MLH1
purine ribonucleoside monophosphate metabolic process (GO:0009167) NEW4.70.006MSH6, MSH2, PMS2, MLH1
nucleoside catabolic process (GO:0009164) NEW6.170.0MSH6, MSH2, PMS2, MLH1
ribonucleoside monophosphate metabolic process (GO:0009161) NEW4.620.007MSH6, MSH2, PMS2, MLH1
purine ribonucleoside catabolic process (GO:0046130) NEW7.160.0MSH6, MSH2, PMS2, MLH1
organic cyclic compound catabolic process (GO:1901361) NEW3.730.003MSH6, MSH2, PMS2, MLH1
single-organism catabolic process (GO:0044712) NEW3.210.008MSH6, MSH2, PMS2, MLH1
cell activation involved in immune response (GO:0002263) -4.860.013MSH6, MSH2, MLH1
ribonucleoside triphosphate metabolic process (GO:0009199) NEW4.770.001MSH6, MSH2, PMS2, MLH1
purine ribonucleoside triphosphate catabolic process (GO:0009207) NEW9.730.0MSH6, MSH2, PMS2, MLH1
purine ribonucleoside triphosphate metabolic process (GO:0009205) NEW4.810.044MSH6, MSH2, PMS2, MLH1
negative regulation of DNA metabolic process (GO:0051053) -4.980.0MSH6, MSH2, MLH1
regulation of DNA metabolic process (GO:0051052) -3.870.003MSH6, MSH2, MLH1
DNA repair (GO:0006281) -3.590.002MSH6, MSH2, PMS2, MLH1
ATP metabolic process (GO:0046034) NEW4.980.0MSH6, MSH2, PMS2, MLH1
lymphocyte activation (GO:0046649) -3.960.005MSH6, MSH2, MLH1
purine ribonucleoside metabolic process (GO:0046128) NEW4.330.001MSH6, MSH2, PMS2, MLH1
ribonucleoside catabolic process (GO:0042454) NEW6.550.035MSH6, MSH2, PMS2, MLH1
organonitrogen compound metabolic process (GO:1901564) NEW2.320.031MSH6, MSH2, PMS2, MLH1
organonitrogen compound catabolic process (GO:1901565) NEW3.910.002MSH6, MSH2, PMS2, MLH1
resolution of meiotic recombination intermediates (GO:0000712) NEW7.430.005MSH2, MLH1
meiotic mismatch repair (GO:0000710) -8.120.0MSH2, MSH6
regulation of DNA recombination (GO:0000018) -5.650.0MSH6, MSH2, MLH1
immune system process (GO:0002376) -2.290.032MSH6, MSH2, PMS2, MLH1
cellular response to stress (GO:0033554) -2.510.006MSH6, MSH2, PMS2, MLH1
organophosphate metabolic process (GO:0019637) NEW3.040.008MSH6, MSH2, PMS2, MLH1
somatic diversification of immunoglobulins (GO:0016445) -6.260.0MSH6, MSH2, PMS2, MLH1
somatic cell DNA recombination (GO:0016444) -6.230.0MSH6, MSH2, PMS2, MLH1
somatic recombination of immunoglobulin gene segments (GO:0016447) -6.680.0MSH6, MSH2, PMS2, MLH1
somatic hypermutation of immunoglobulin genes (GO:0016446) -6.90.0MSH6, MSH2, PMS2, MLH1
nucleoside triphosphate metabolic process (GO:0009141) NEW4.610.001MSH6, MSH2, PMS2, MLH1
nucleoside triphosphate catabolic process (GO:0009143) NEW7.240.0MSH6, MSH2, PMS2, MLH1
purine nucleoside triphosphate metabolic process (GO:0009144) NEW4.760.045MSH6, MSH2, PMS2, MLH1
mismatch repair (GO:0006298) -6.230.0MSH6, MSH2, PMS2, MLH1
purine nucleoside triphosphate catabolic process (GO:0009146) NEW7.940.0MSH6, MSH2, PMS2, MLH1
leukocyte activation (GO:0045321) -3.760.009MSH2, MSH6, MLH1
purine nucleotide catabolic process (GO:0006195) NEW6.070.038MSH6, MSH2, PMS2, MLH1
purine nucleotide metabolic process (GO:0006163) NEW4.090.001MSH6, MSH2, PMS2, MLH1
organic substance catabolic process (GO:1901575) NEW2.450.04MSH6, MSH2, PMS2, MLH1
lymphocyte activation involved in immune response (GO:0002285) -5.220.004MSH6, MSH2, MLH1
somatic diversification of immunoglobulins involved in immune response (GO:0002208) -6.960.0MSH6, MSH2, MLH1
leukocyte activation involved in immune response (GO:0002366) -4.880.013MSH6, MSH2, MLH1
somatic diversification of immune receptors (GO:0002200) -5.920.0MSH6, MSH2, PMS2, MLH1
negative regulation of DNA recombination (GO:0045910) -6.960.0MSH2, MSH6, MLH1
somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) -6.960.0MSH2, MSH6, MLH1
ribonucleoside monophosphate catabolic process (GO:0009158) NEW8.120.002MSH6, MSH2, PMS2, MLH1
purine ribonucleotide catabolic process (GO:0009154) NEW6.470.0MSH6, MSH2, PMS2, MLH1
heterocycle catabolic process (GO:0046700) NEW3.820.003MSH6, MSH2, PMS2, MLH1
ribonucleotide catabolic process (GO:0009261) NEW6.430.0MSH6, MSH2, PMS2, MLH1
aromatic compound catabolic process (GO:0019439) NEW3.790.003MSH6, MSH2, PMS2, MLH1
cell activation (GO:0001775) -3.470.035MSH2, MSH6, MLH1
nucleobase-containing compound catabolic process (GO:0034655) NEW3.90.002MSH6, MSH2, PMS2, MLH1
purine ribonucleotide metabolic process (GO:0009150) NEW4.160.001MSH6, MSH2, PMS2, MLH1
cellular nitrogen compound catabolic process (GO:0044270) NEW3.80.003MSH6, MSH2, PMS2, MLH1
nucleoside phosphate catabolic process (GO:1901292) NEW5.540.0MSH6, MSH2, PMS2, MLH1
nucleoside phosphate metabolic process (GO:0006753) NEW3.710.002MSH6, MSH2, PMS2, MLH1
cellular catabolic process (GO:0044248) NEW2.620.028MSH6, MSH2, PMS2, MLH1
purine nucleoside monophosphate catabolic process (GO:0009128) NEW7.940.002MSH6, MSH2, PMS2, MLH1
nucleoside monophosphate metabolic process (GO:0009123) NEW4.540.0MSH6, MSH2, PMS2, MLH1
purine nucleoside monophosphate metabolic process (GO:0009126) NEW4.690.0MSH6, MSH2, PMS2, MLH1
ribonucleotide metabolic process (GO:0009259) NEW4.110.001MSH6, MSH2, PMS2, MLH1
nucleoside monophosphate catabolic process (GO:0009125) NEW7.650.0MSH6, MSH2, PMS2, MLH1
purine nucleoside metabolic process (GO:0042278) NEW4.320.001MSH6, MSH2, PMS2, MLH1
synapsis (GO:0007129) NEW6.780.004MSH2, MLH1
isotype switching (GO:0045190) -6.960.0MSH2, MSH6, MLH1
cellular response to DNA damage stimulus (GO:0006974) -3.170.001MSH6, MSH2, PMS2, MLH1
positive regulation of helicase activity (GO:0051096) -7.940.0MSH2, MSH6
reciprocal meiotic recombination (GO:0007131) -6.330.03MLH1, MSH6
intrinsic apoptotic signaling pathway (GO:0097193) -4.690.016MSH6, MSH2, MLH1
nucleobase-containing small molecule metabolic process (GO:0055086) NEW3.590.003MSH6, MSH2, PMS2, MLH1
chromosome organization involved in meiosis (GO:0070192) NEW5.90.05MSH2, MLH1
intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630) -5.440.0MSH6, MSH2, MLH1
regulation of helicase activity (GO:0051095) -7.530.0MSH2, MSH6
carbohydrate derivative catabolic process (GO:1901136) NEW4.610.001MSH6, MSH2, PMS2, MLH1
carbohydrate derivative metabolic process (GO:1901135) NEW3.070.008MSH6, MSH2, PMS2, MLH1
ribonucleoside triphosphate catabolic process (GO:0009203) NEW9.730.0MSH6, MSH2, PMS2, MLH1
apoptotic signaling pathway (GO:0097190) -4.120.006MSH6, MSH2, MLH1
B cell activation (GO:0042113) -4.840.0MSH6, MSH2, MLH1
meiotic cell cycle process (GO:1903046) -4.710.004MSH2, MSH6, MLH1
meiotic chromosome separation (GO:0051307) NEW9.040.005MSH2, MLH1
purine-containing compound metabolic process (GO:0072521) NEW4.00.001MSH6, MSH2, PMS2, MLH1
purine-containing compound catabolic process (GO:0072523) NEW5.920.04MSH6, MSH2, PMS2, MLH1
chromosome separation (GO:0051304) NEW7.430.012MSH2, MLH1
purine nucleoside catabolic process (GO:0006152) NEW7.160.0MSH6, MSH2, PMS2, MLH1
nucleotide metabolic process (GO:0009117) NEW3.730.002MSH6, MSH2, PMS2, MLH1
nucleoside metabolic process (GO:0009116) NEW4.120.001MSH6, MSH2, PMS2, MLH1
determination of adult lifespan (GO:0008340) -7.090.004MSH2, MSH6
ribonucleoside metabolic process (GO:0009119) NEW4.210.001MSH6, MSH2, PMS2, MLH1
DNA recombination (GO:0006310) -4.390.0MSH6, MSH2, PMS2, MLH1
somatic diversification of immune receptors via germline recombination within a single locus (GO:0002562) -6.230.0MSH6, MSH2, PMS2, MLH1
somatic diversification of immune receptors via somatic mutation (GO:0002566) -6.840.0MSH6, MSH2, PMS2, MLH1
purine ribonucleoside monophosphate catabolic process (GO:0009169) NEW8.120.002MSH6, MSH2, PMS2, MLH1
ribose phosphate metabolic process (GO:0019693) NEW4.060.001MSH6, MSH2, PMS2, MLH1
glycosyl compound metabolic process (GO:1901657) NEW4.040.001MSH6, MSH2, PMS2, MLH1
B cell activation involved in immune response (GO:0002312) -6.170.0MSH2, MSH6, MLH1
immune effector process (GO:0002252) -3.580.027MSH6, MSH2, MLH1
DNA metabolic process (GO:0006259) -3.090.001MSH6, MSH2, PMS2, MLH1
reciprocal DNA recombination (GO:0035825) -6.330.03MSH6, MLH1
glycosyl compound catabolic process (GO:1901658) NEW6.020.04MSH6, MSH2, PMS2, MLH1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
protein complex (GO:0043234) 1.514MSH6, MSH2, PMS2, MLH1
intracellular organelle part (GO:0044446) 0.814MSH6, MSH2, PMS2, MLH1
macromolecular complex (GO:0032991) 1.354MSH6, PMS2, MSH2, MLH1
intracellular membrane-bounded organelle (GO:0043231) 0.64MSH6, PMS2, MSH2, MLH1
DNA repair complex (GO:1990391) 6.144MSH6, MSH2, PMS2, MLH1
nucleus (GO:0005634) 1.074MSH6, MSH2, PMS2, MLH1
cell part (GO:0044464) 0.114MSH6, MSH2, PMS2, MLH1
nucleoplasm (GO:0005654) 1.894MSH6, MSH2, PMS2, MLH1
intracellular organelle (GO:0043229) 0.514MSH6, MSH2, PMS2, MLH1
mismatch repair complex (GO:0032300) 7.034MSH6, PMS2, MSH2, MLH1
intracellular part (GO:0044424) 0.284MSH6, MSH2, PMS2, MLH1
nuclear part (GO:0044428) 1.554MSH6, PMS2, MSH2, MLH1
membrane-bounded organelle (GO:0043227) 0.474MSH6, MSH2, PMS2, MLH1
organelle (GO:0043226) 0.44MSH6, MSH2, PMS2, MLH1
organelle part (GO:0044422) 0.794MSH6, MSH2, PMS2, MLH1
membrane (GO:0016020) 0.683MSH2, MSH6, MLH1
non-membrane-bounded organelle (GO:0043228) 1.763PMS2, MSH6, MLH1
chromosomal part (GO:0044427) 3.183MSH6, MSH2, MLH1
intracellular non-membrane-bounded organelle (GO:0043232) 1.763MSH6, PMS2, MLH1
nuclear chromosome part (GO:0044454) 3.673MSH6, MSH2, MLH1
cytoplasm (GO:0005737) 1.012PMS2, MSH6
nuclear chromosome (GO:0000228) 5.552MLH1, MSH6
chromosome (GO:0005694) 3.782MSH6, MLH1
MutLalpha complex (GO:0032389) 7.722PMS2, MLH1
MutSalpha complex (GO:0032301) 9.112MSH2, MSH6

NET-GE enrichment

Term New enriched termICP valueGenes
MutLalpha complex (GO:0032389) -7.720.0PMS2, MLH1
DNA repair complex (GO:1990391) -6.140.0MSH6, MSH2, PMS2, MLH1
nuclear chromosome part (GO:0044454) -3.670.0MSH6, MSH2, PMS2, MLH1
mismatch repair complex (GO:0032300) -7.030.0MSH6, MSH2, PMS2, MLH1
MutSalpha complex (GO:0032301) -9.110.0MSH2, MSH6
nuclear part (GO:0044428) -1.550.013MSH6, PMS2, MSH2, MLH1
nuclear chromosome (GO:0000228) -5.550.011MSH2, MSH6
chromosomal part (GO:0044427) -3.180.003MSH6, MSH2, PMS2, MLH1
chromosome (GO:0005694) -3.780.017MSH2, MSH6
male germ cell nucleus (GO:0001673) NEW6.970.002MLH1, MSH6
germ cell nucleus (GO:0043073) NEW6.760.004MLH1, MSH6