Disease table of MEIER-GORLIN SYNDROME OMIM ID: PS224690

Gene-disease associations table

Gene	Associated with MEIER-GORLIN SYNDROME in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
ORC6	ClinVar, OMIM, HUMSAVAR	HGNC link	16q11.2	1	PS224690
ORC4	ClinVar, OMIM, HUMSAVAR	HGNC link	2q23.1	1	PS224690
CDT1	ClinVar, OMIM, HUMSAVAR	HGNC link	16q24.3	1	PS224690
ORC1	ClinVar, OMIM, HUMSAVAR	HGNC link	1p32.3	1	PS224690
GMNN	ClinVar, OMIM	HGNC link	6p22.3	1	PS224690
CDC6	ClinVar, OMIM, HUMSAVAR	HGNC link	17q21.2	1	PS224690

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
16q	2	ORC6, CDT1

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
16	2	ORC6, CDT1

Transcription Factors (TF) annotation from TRRUST

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
CDT1	YES	1	KLF5	0
CDC6	YES	3	AR, GATA1, MSC	0

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
ORC6	ORC4	Yes	14	XRCC5, CDC5L, ORC5, MCM2, XRCC6, MCM6, MCM7, ORC3, DBF4, ORC2, SNW1, LRWD1, MCM4, APP
ORC6	CDT1	No	6	CDC5L, CDC6, MCM4, MCM6, ORC2, MCM2
ORC6	ORC1	No	17	DBF4, TERF2, ORC4, CDC5L, CDC6, ORC5, MCM2, MCM6, MCM7, ORC3, CDC7, MCM5, ORC2, LRWD1, MCM4, XRCC5, CDC45
ORC6	GMNN	No	1	MCM6
ORC6	CDC6	Yes	5	ORC5, MCM2, ORC2, MCM7, ORC3
ORC4	CDT1	No	6	CDC5L, MCM4, MCM2, MCM6, ORC2, ORC1
ORC4	ORC1	Yes	13	ORC2, CDC5L, ORC5, MCM2, MCM6, MCM7, ORC3, DBF4, RPA2, CBX1, LRWD1, MCM4, XRCC5
ORC4	GMNN	No	2	MCM6, CDKN2A
ORC4	CDC6	No	11	ORC5, MCM2, MCM3, ORC6, ORC3, MCM10, CCL2, ORC2, CDKN2A, ORC1, MCM7
CDT1	ORC1	Yes	10	CCNA2, CDC5L, CDK2, CDC6, MCM4, MCM6, SKP2, ORC2, MCM2, KAT7
CDT1	GMNN	Yes	9	CDK1, CDK2, FZR1, CDK3, MCM6, CCNA2, CDC20, HDAC11, KAT7
CDT1	CDC6	Yes	13	CDK1, CCNE1, CCNB1, CDK2, CDC20, FZR1, ORC1, CDK4, KAT7, ORC2, PCNA, MCM2, CCNA2
ORC1	GMNN	No	5	CCNA2, KAT7, MCM6, CDK2, CDT1
ORC1	CDC6	Yes	9	CCNA2, CDK2, ORC5, MCM7, ORC3, CDT1, ORC2, MCM2, KAT7
GMNN	CDC6	No	10	ATM, CDKN1A, CDK2, FZR1, CDK1, KAT7, CCNA2, CDKN2A, CDC20, CDT1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
ORC6	ORC4	Yes	binding	41	ATRIP, MCM8, CDK2, KITLG, ORC5, PRIM1, MCM7, MCM3, ORC2, POLA1, LRWD1, RPA3, ATR, CCNE1, POLE, ORC1, RPA4, RPA1, ORC3, RPA2, CDKN1A, CDC7, FZR1, MCM6, POLA2, CDK1, DBF4, CLSPN, REPIN1, CDC6, MCM4, MCM5, RB1, MCM10, CDKN1B, CCNB1, UBC, POLE2, MCM2, CDT1, CDC45
ORC6	CDT1	Yes	binding	26	MCM8, KITLG, ORC5, CDK1, MCM7, MCM3, ORC2, POLA1, CCNE1, MCM2, ORC1, CDC45, ORC3, CDKN1A, ORC4, MCM6, CDK2, CDC6, MCM4, MCM5, RB1, MCM10, CCNB1, UBC, FZR1, CDKN1B
ORC6	ORC1	Yes	binding	41	ATRIP, MCM8, CDK2, KITLG, ORC5, PRIM1, MCM7, MCM3, ORC2, POLA1, LRWD1, RPA3, ATR, CCNE1, POLE, MCM2, RPA4, RPA1, ORC3, RPA2, CDKN1A, CCNB1, CDC7, MCM6, POLA2, CDK1, DBF4, CLSPN, REPIN1, CDC6, MCM4, MCM5, RB1, MCM10, CDKN1B, ORC4, UBC, POLE2, FZR1, CDT1, CDC45
ORC6	GMNN	No	-	2	UBC, CDT1
ORC6	CDC6	Yes	binding	39	ATRIP, PRIM1, CDC45, KITLG, ORC5, MCM8, MCM7, MCM3, ORC2, POLA1, RPA3, ATR, CCNE1, POLE, ORC1, RPA4, RPA1, ORC3, RPA2, CDKN1A, CCNB1, CDC7, FZR1, MCM6, POLA2, CDK1, DBF4, CLSPN, CDK2, MCM4, MCM5, RB1, MCM10, CDKN1B, ORC4, UBC, POLE2, MCM2, CDT1
ORC4	CDT1	Yes	binding	26	MCM8, KITLG, ORC5, CDK1, MCM7, ORC6, ORC2, POLA1, CCNE1, MCM2, ORC1, CDC45, ORC3, CDKN1A, MCM3, MCM6, CDK2, CDC6, MCM4, MCM5, RB1, MCM10, CCNB1, UBC, FZR1, CDKN1B
ORC4	ORC1	Yes	binding	44	ATRIP, MCM8, CDK2, KITLG, ORC5, PRIM1, MCM7, RBBP7, MCM5, ORC2, POLA1, LRWD1, RPA3, ATR, CCNE1, POLE, MCM2, RPA4, RPA1, ORC3, RPA2, CDKN1A, CDC7, MCM3, MCM6, POLA2, CDK1, DBF4, CLSPN, REPIN1, CDC6, POLE2, MCM4, ORC6, HAT1, RB1, MCM10, CDKN1B, CCNB1, UBC, RBBP4, FZR1, CDT1, CDC45
ORC4	GMNN	No	-	2	UBC, CDT1
ORC4	CDC6	Yes	binding	40	ATRIP, PRIM1, CDC45, KITLG, ORC5, MCM8, MCM7, MCM5, ORC2, POLA1, RPA3, ATR, CCNE1, POLE, ORC1, RPA4, RPA1, FZR1, ORC3, RPA2, CDKN1A, CDC7, MCM3, MCM6, POLA2, CDK1, DBF4, CLSPN, CDK2, POLE2, MCM4, ORC6, RB1, MCM10, CDKN1B, CCNB1, UBC, RBBP4, MCM2, CDT1
CDT1	ORC1	Yes	binding	40	CDK1, KITLG, ORC5, MCM8, MCM7, MCM5, ORC2, POLA1, UBB, CCNA2, RPS27A, CCNE1, TYMS, KAT7, MCM2, CDC45, ORC3, DHFR, E2F1, TFDP1, CDKN1A, CCNB1, UBA52, MCM3, MCM9, RRM2, MCM6, PCNA, CDC6, CDK2, MCM4, CCNA1, ORC6, FBXO5, RB1, MCM10, ORC4, UBC, FZR1, CDKN1B
CDT1	GMNN	Yes	binding	6	RPS27A, UBA52, FBXO5, UBC, UBB, CDC20
CDT1	CDC6	Yes	binding	42	CDK1, KITLG, ORC5, MCM8, MCM7, MCM5, ORC2, POLA1, UBB, CCNA2, RPS27A, CCNE1, TYMS, ORC1, CDC45, ORC3, DHFR, E2F1, CDC20, TFDP1, CDKN1A, CCNB1, UBA52, MCM3, MCM9, RRM2, MCM6, TOP2A, CDK4, PCNA, FZR1, CDK2, MCM4, CCNA1, ORC6, FBXO5, RB1, MCM10, ORC4, UBC, MCM2, CDKN1B
ORC1	GMNN	No	-	47	PSMC4, PSME1, PSMC1, PSMC6, PSMB3, PSMD6, PSMB11, PSMB4, PSMA8, PSMD14, PSMD1, PSMC3, PSMD9, PSMF1, RPS27A, PSMB2, PSMD3, PSMC2, PSMD2, PSMD11, PSME2, PSMA1, UBA52, PSMD4, PSMD12, PSMB6, PSMD5, PSMA7, PSMA4, PSMA6, PSMB1, PSMB10, PSMD8, PSMD10, PSMD7, PSME3, PSMB5, UBB, PSME4, PSMC5, FBXO5, PSMD13, PSMB7, PSMA5, UBC, PSMA3, CDT1
ORC1	CDC6	Yes	binding	99	ATRIP, PSMC4, KITLG, PSMC3, MCM8, PSMD1, DHFR, PSMB5, RPA1, PSMD11, UBA52, PSMD5, PSMB1, MCM6, PCNA, CLSPN, PSMD6, E2F1, PSMD10, PSME3, MCMDC2, MCM3, CDC45, E2F3, MCM7, UBB, PSMD3, CCNE1, PSME1, ORC3, PSME2, RPA2, PSMD4, PSMA7, CDC7, PSME4, TYMS, PSMC5, ORC6, PSMB2, CCNB1, UBC, PSMA3, CDT1, PRIM1, PSMD14, ORC5, RRM2, PSMA8, ORC2, CCNA2, CDK3, POLE, MCM2, PSMA5, PSMB10, PSMD12, PSMD7, POLA2, CDK2, FZR1, MCM5, RB1, ORC4, CDKN1B, CDK1, PSMC1, PSMB3, PSMB11, DBF4, POLA1, PSMD9, PSMF1, RPS27A, PSMC2, PSMB4, RPA4, E2F2, PSMA1, TFDP1, CDKN1A, PSMB6, ATR, PSMA6, MCM9, PSMC6, PSMD8, PSMD2, RBBP4, MCM4, CCNA1, FBXO5, PSMD13, MCM10, RPA3, MYC, POLE2, PSMB7, PSMA4
GMNN	CDC6	No	-	48	PSMC4, PSME1, PSMC1, PSMC6, PSMB3, PSMD6, PSMB11, PSMB4, PSMA8, PSMD14, PSMD1, PSMC3, PSMD9, PSMF1, RPS27A, PSMB2, PSMD3, PSMC2, PSMD2, PSMD11, PSME2, PSMA1, UBA52, PSMD4, PSMD12, PSMB6, PSMD5, PSMA7, PSMA4, PSMA6, PSME4, PSMB1, PSMB10, PSMD8, PSMD10, PSMD7, PSME3, PSMB5, UBB, CDC20, PSMC5, FBXO5, PSMD13, PSMB7, PSMA5, UBC, PSMA3, CDT1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
ORC6	ORC4	Yes	ORC complex (origin recognition complex);Ku-ORC complex	6	ORC5, XRCC6, ORC3, ORC2, ORC1, XRCC5
ORC6	ORC1	Yes	ORC complex (origin recognition complex)	4	ORC5, ORC2, ORC4, ORC3
ORC6	GMNN	No	-	1	ORC1
ORC6	CDC6	No	-	2	ORC1, ORC2
ORC4	ORC1	Yes	ORC 1-5 complex (origin recognition 1-5 complex);ORC complex (origin recognition complex)	4	ORC5, ORC2, ORC6, ORC3
ORC4	GMNN	No	-	1	ORC1
ORC4	CDC6	No	-	2	ORC1, ORC2
ORC1	GMNN	Yes	BRCA1-IRIS-pre-replication complex	2	BRCA1, CDC6
ORC1	CDC6	Yes	BRCA1-IRIS-pre-replication complex	3	BRCA1, ORC2, GMNN
GMNN	CDC6	Yes	BRCA1-IRIS-pre-replication complex	2	BRCA1, ORC1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
CDT1	GMNN	Yes	2	CDT1, GMNN

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Cell cycle	hsa04110	5.68	4	CDC6, ORC1, ORC4, ORC6

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Cell cycle (hsa04110)	-	5.68	0.0	CDC6, ORC1, ORC4, ORC6
Cell growth and death	NEW	4.41	0.0	CDT1, ORC1, CDC6, ORC4, ORC6
Cellular Processes	NEW	2.22	0.008	CDC6, ORC1, ORC4, ORC6

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Assembly of the pre-replicative complex	R-HSA-68867	6.92	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
Regulation of DNA replication	R-HSA-69304	6.75	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
DNA Replication	R-HSA-69306	6.25	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
Cell Cycle, Mitotic	R-HSA-69278	4.16	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
M/G1 Transition	R-HSA-68874	6.62	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
CDT1 association with the CDC6:ORC:origin complex	R-HSA-68827	7.12	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
Removal of licensing factors from origins	R-HSA-69300	6.81	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
Cell Cycle	R-HSA-1640170	3.89	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
DNA Replication Pre-Initiation	R-HSA-69002	6.62	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
Mitotic G1-G1/S phases	R-HSA-453279	5.91	5	CDT1, ORC1, CDC6, ORC4, ORC6
Switching of origins to a post-replicative state	R-HSA-69052	6.85	5	CDT1, ORC1, CDC6, ORC4, ORC6
Activation of the pre-replicative complex	R-HSA-68962	8.08	5	CDT1, ORC1, CDC6, ORC4, ORC6
G1/S Transition	R-HSA-69206	6.21	5	CDT1, ORC1, CDC6, ORC4, ORC6
S Phase	R-HSA-69242	6.02	5	CDT1, ORC1, CDC6, ORC4, ORC6
Orc1 removal from chromatin	R-HSA-68949	6.85	5	CDT1, ORC1, CDC6, ORC4, ORC6
Association of licensing factors with the pre-replicative complex	R-HSA-69298	9.08	5	CDT1, ORC1, CDC6, ORC4, GMNN
E2F mediated regulation of DNA replication	R-HSA-113510	7.94	5	CDT1, ORC1, CDC6, ORC4, ORC6
Synthesis of DNA	R-HSA-69239	6.37	5	CDT1, ORC1, CDC6, ORC4, ORC6
Cell Cycle Checkpoints	R-HSA-69620	5.64	4	CDC6, ORC1, ORC4, ORC6
G2/M Checkpoints	R-HSA-69481	6.46	4	CDC6, ORC1, ORC4, ORC6
CDC6 association with the ORC:origin complex	R-HSA-68689	9.52	4	CDC6, ORC1, ORC4, ORC6
Activation of ATR in response to replication stress	R-HSA-176187	7.77	4	CDC6, ORC1, ORC4, ORC6
Assembly of the ORC complex at the origin of replication	R-HSA-68616	10.4	3	ORC1, ORC4, ORC6
G1/S-Specific Transcription	R-HSA-69205	8.89	3	ORC1, CDC6, CDT1
E2F-enabled inhibition of pre-replication complex formation	R-HSA-113507	9.66	3	ORC1, ORC4, ORC6

NET-GE enrichment

Term	New enriched term	IC	Genes
Activation of the pre-replicative complex (R-HSA-68962)	-	8.08	CDT1, ORC1, CDC6, ORC4, ORC6
Cell Cycle, Mitotic (R-HSA-69278)	-	4.16	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
Cell Cycle (R-HSA-1640170)	-	3.89	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
Association of licensing factors with the pre-replicative complex (R-HSA-69298)	-	9.08	CDT1, ORC1, CDC6, ORC4, GMNN
Assembly of the ORC complex at the origin of replication (R-HSA-68616)	-	10.4	ORC1, ORC4, ORC6
CDC6 association with the ORC:origin complex (R-HSA-68689)	-	9.52	CDT1, ORC1, CDC6, ORC4, ORC6
Cell Cycle Checkpoints (R-HSA-69620)	-	5.64	CDC6, ORC1, ORC4, ORC6
Orc1 removal from chromatin (R-HSA-68949)	-	6.85	CDT1, ORC1, CDC6, ORC4, ORC6
CDT1 association with the CDC6:ORC:origin complex (R-HSA-68827)	-	7.12	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
Synthesis of DNA (R-HSA-69239)	-	6.37	CDT1, ORC1, CDC6, ORC4, ORC6
E2F-enabled inhibition of pre-replication complex formation (R-HSA-113507)	-	9.66	CDC6, ORC1, ORC4, ORC6
Mitotic G1-G1/S phases (R-HSA-453279)	-	5.91	CDT1, ORC1, CDC6, ORC4, ORC6
Assembly of the pre-replicative complex (R-HSA-68867)	-	6.92	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
Switching of origins to a post-replicative state (R-HSA-69052)	-	6.85	CDT1, ORC1, CDC6, ORC4, ORC6
DNA Replication Pre-Initiation (R-HSA-69002)	-	6.62	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
G2/M Checkpoints (R-HSA-69481)	-	6.46	CDC6, ORC1, ORC4, ORC6
G1/S Transition (R-HSA-69206)	-	6.21	CDT1, ORC1, CDC6, ORC4, ORC6
G1/S-Specific Transcription (R-HSA-69205)	-	8.89	ORC1, CDC6, CDT1
S Phase (R-HSA-69242)	-	6.02	CDT1, ORC1, CDC6, ORC4, ORC6
DNA Replication (R-HSA-69306)	-	6.25	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
Regulation of DNA replication (R-HSA-69304)	-	6.75	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
Activation of ATR in response to replication stress (R-HSA-176187)	-	7.77	CDC6, ORC1, ORC4, ORC6
Removal of licensing factors from origins (R-HSA-69300)	-	6.81	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
E2F mediated regulation of DNA replication (R-HSA-113510)	-	7.94	CDT1, ORC1, CDC6, ORC4, ORC6
M/G1 Transition (R-HSA-68874)	-	6.62	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN

GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
protein binding (GO:0005515)	0.46	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
organic cyclic compound binding (GO:0097159)	1.05	5	CDT1, ORC1, CDC6, ORC4, ORC6
heterocyclic compound binding (GO:1901363)	1.06	5	CDT1, ORC1, CDC6, ORC4, ORC6
nucleic acid binding (GO:0003676)	1.44	4	CDT1, ORC1, ORC4, ORC6
DNA binding (GO:0003677)	1.92	4	CDT1, ORC1, ORC4, ORC6
adenyl nucleotide binding (GO:0030554)	2.4	3	ORC1, CDC6, ORC4
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	3	ORC1, CDC6, ORC4
ribonucleoside binding (GO:0032549)	2.22	3	ORC1, CDC6, ORC4
ribonucleotide binding (GO:0032553)	2.19	3	ORC1, CDC6, ORC4
nucleotide binding (GO:0000166)	1.96	3	ORC1, CDC6, ORC4
small molecule binding (GO:0036094)	1.89	3	ORC1, CDC6, ORC4
carbohydrate derivative binding (GO:0097367)	2.03	3	ORC1, CDC6, ORC4
adenyl ribonucleotide binding (GO:0032559)	2.41	3	ORC1, CDC6, ORC4
purine nucleoside binding (GO:0001883)	2.22	3	ORC1, CDC6, ORC4
ATP binding (GO:0005524)	2.43	3	ORC1, CDC6, ORC4
purine ribonucleotide binding (GO:0032555)	2.2	3	ORC1, CDC6, ORC4
purine nucleotide binding (GO:0017076)	2.19	3	ORC1, CDC6, ORC4
purine ribonucleoside binding (GO:0032550)	2.22	3	ORC1, CDC6, ORC4
nucleoside phosphate binding (GO:1901265)	1.96	3	ORC1, CDC6, ORC4
nucleoside binding (GO:0001882)	2.21	3	ORC1, CDC6, ORC4
enzyme binding (GO:0019899)	2.27	2	CDC6, GMNN

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
primary metabolic process (GO:0044238)	0.69	5	CDT1, ORC1, CDC6, ORC4, ORC6
G1/S transition of mitotic cell cycle (GO:0000082)	5.12	5	CDT1, ORC1, CDC6, ORC4, ORC6
mitotic cell cycle process (GO:1903047)	3.12	5	CDT1, ORC1, CDC6, ORC4, ORC6
cell cycle phase transition (GO:0044770)	4.24	5	CDT1, ORC1, CDC6, ORC4, ORC6
cellular biosynthetic process (GO:0044249)	1.37	5	CDT1, ORC1, CDC6, ORC4, ORC6
mitotic cell cycle phase transition (GO:0044772)	4.27	5	CDT1, ORC1, CDC6, ORC4, ORC6
nitrogen compound metabolic process (GO:0006807)	1.13	5	CDT1, ORC1, CDC6, ORC4, ORC6
cell cycle process (GO:0022402)	2.75	5	CDT1, ORC1, CDC6, ORC4, ORC6
cellular macromolecule biosynthetic process (GO:0034645)	1.66	5	CDT1, ORC1, CDC6, ORC4, ORC6
organic cyclic compound metabolic process (GO:1901360)	1.26	5	CDT1, ORC1, CDC6, ORC4, ORC6
organic substance biosynthetic process (GO:1901576)	1.34	5	CDT1, ORC1, CDC6, ORC4, ORC6
cellular macromolecule metabolic process (GO:0044260)	0.93	5	CDT1, ORC1, CDC6, ORC4, ORC6
organic substance metabolic process (GO:0071704)	0.63	5	CDT1, ORC1, CDC6, ORC4, ORC6
DNA replication (GO:0006260)	4.51	5	CDT1, ORC1, CDC6, ORC4, ORC6
nucleobase-containing compound metabolic process (GO:0006139)	1.35	5	CDT1, ORC1, CDC6, ORC4, ORC6
cellular aromatic compound metabolic process (GO:0006725)	1.3	5	CDT1, ORC1, CDC6, ORC4, ORC6
biosynthetic process (GO:0009058)	1.32	5	CDT1, ORC1, CDC6, ORC4, ORC6
macromolecule biosynthetic process (GO:0009059)	1.61	5	CDT1, ORC1, CDC6, ORC4, ORC6
metabolic process (GO:0008152)	0.58	5	CDT1, ORC1, CDC6, ORC4, ORC6
cell cycle G1/S phase transition (GO:0044843)	5.12	5	CDT1, ORC1, CDC6, ORC4, ORC6
heterocycle metabolic process (GO:0046483)	1.31	5	CDT1, ORC1, CDC6, ORC4, ORC6
nucleic acid metabolic process (GO:0090304)	1.46	5	CDT1, ORC1, CDC6, ORC4, ORC6
cellular nitrogen compound metabolic process (GO:0034641)	1.22	5	CDT1, ORC1, CDC6, ORC4, ORC6
cellular metabolic process (GO:0044237)	0.69	5	CDT1, ORC1, CDC6, ORC4, ORC6
macromolecule metabolic process (GO:0043170)	0.83	5	CDT1, ORC1, CDC6, ORC4, ORC6
DNA metabolic process (GO:0006259)	3.09	5	CDT1, ORC1, CDC6, ORC4, ORC6
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	4	CDC6, ORC1, CDT1, GMNN
regulation of primary metabolic process (GO:0080090)	1.08	4	CDC6, ORC1, CDT1, GMNN
regulation of metabolic process (GO:0019222)	1.02	4	CDC6, ORC1, CDT1, GMNN
regulation of cell cycle (GO:0051726)	2.93	4	CDC6, ORC1, CDT1, GMNN
regulation of macromolecule metabolic process (GO:0060255)	1.08	4	CDC6, ORC1, CDT1, GMNN
regulation of cellular biosynthetic process (GO:0031326)	1.38	4	CDC6, ORC1, CDT1, GMNN
regulation of cellular metabolic process (GO:0031323)	1.07	4	CDC6, ORC1, CDT1, GMNN
regulation of RNA metabolic process (GO:0051252)	1.52	4	CDC6, ORC1, CDT1, GMNN
regulation of biosynthetic process (GO:0009889)	1.37	4	CDC6, ORC1, CDT1, GMNN
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	4	CDC6, ORC1, CDT1, GMNN
regulation of cellular process (GO:0050794)	0.5	4	CDC6, ORC1, CDT1, GMNN
regulation of transcription, DNA-templated (GO:0006355)	1.56	4	CDC6, ORC1, CDT1, GMNN
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	4	CDC6, ORC1, CDT1, GMNN
biological regulation (GO:0065007)	0.39	4	CDC6, ORC1, CDT1, GMNN
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	4	CDC6, ORC1, CDT1, GMNN
regulation of RNA biosynthetic process (GO:2001141)	1.55	4	CDC6, ORC1, CDT1, GMNN
regulation of gene expression (GO:0010468)	1.37	4	CDC6, ORC1, CDT1, GMNN
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	4	CDC6, ORC1, CDT1, GMNN
regulation of biological process (GO:0050789)	0.45	4	CDC6, ORC1, CDT1, GMNN
regulation of DNA metabolic process (GO:0051052)	3.87	3	CDC6, CDT1, GMNN
DNA replication initiation (GO:0006270)	6.36	3	ORC1, CDC6, ORC4
regulation of cell cycle process (GO:0010564)	3.5	3	ORC1, CDC6, CDT1
regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	6.47	3	ORC1, CDC6, CDT1
regulation of DNA replication (GO:0006275)	5.02	3	CDC6, CDT1, GMNN
single-organism cellular process (GO:0044763)	0.65	3	CDC6, CDT1, GMNN
cell cycle (GO:0007049)	3.14	3	CDC6, CDT1, GMNN
single-organism process (GO:0044699)	0.48	3	CDC6, CDT1, GMNN
positive regulation of cell proliferation (GO:0008284)	3.01	2	ORC1, CDC6
negative regulation of metabolic process (GO:0009892)	1.93	2	CDC6, GMNN
negative regulation of biosynthetic process (GO:0009890)	2.47	2	CDC6, GMNN
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	2	CDC6, GMNN
negative regulation of cellular metabolic process (GO:0031324)	2.01	2	CDC6, GMNN
cellular component organization or biogenesis (GO:0071840)	1.22	2	CDC6, GMNN
positive regulation of cell cycle process (GO:0090068)	4.25	2	ORC1, CDC6
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	2	CDC6, GMNN
positive regulation of cell cycle (GO:0045787)	3.94	2	ORC1, CDC6
DNA integrity checkpoint (GO:0031570)	5.25	2	CDC6, CDT1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	2	CDC6, GMNN
cellular component organization (GO:0016043)	1.24	2	CDC6, GMNN
positive regulation of biological process (GO:0048518)	1.2	2	ORC1, CDC6
negative regulation of biological process (GO:0048519)	1.33	2	CDC6, GMNN
regulation of cell proliferation (GO:0042127)	2.41	2	ORC1, CDC6
negative regulation of DNA metabolic process (GO:0051053)	4.98	2	CDC6, GMNN
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	2	CDC6, GMNN
negative regulation of DNA replication (GO:0008156)	6.17	2	CDC6, GMNN
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	2	CDC6, GMNN
DNA replication checkpoint (GO:0000076)	7.02	2	CDC6, CDT1
cell cycle checkpoint (GO:0000075)	4.79	2	CDC6, CDT1
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	2	CDC6, GMNN
negative regulation of cellular process (GO:0048523)	1.41	2	CDC6, GMNN
positive regulation of cellular process (GO:0048522)	1.3	2	ORC1, CDC6

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
negative regulation of DNA metabolic process (GO:0051053)	-	4.98	0.034	CDC6, GMNN
regulation of DNA metabolic process (GO:0051052)	-	3.87	0.007	CDC6, ORC1, CDT1, GMNN
regulation of cellular protein catabolic process (GO:1903362)	NEW	4.23	0.041	CDC6, CDT1, GMNN
regulation of proteasomal protein catabolic process (GO:0061136)	NEW	4.78	0.014	CDC6, CDT1, GMNN
regulation of proteolysis involved in cellular protein catabolic process (GO:1903050)	NEW	4.32	0.033	CDC6, CDT1, GMNN
DNA replication initiation (GO:0006270)	-	6.36	0.021	ORC1, ORC4
G1/S transition of mitotic cell cycle (GO:0000082)	-	5.12	0.0	CDT1, ORC1, CDC6, ORC4, ORC6
mitotic cell cycle phase transition (GO:0044772)	-	4.27	0.0	CDT1, ORC1, CDC6, ORC4, ORC6
mitotic cell cycle process (GO:1903047)	-	3.12	0.0	CDT1, ORC1, CDC6, ORC4, ORC6
regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	-	6.47	0.0	ORC1, CDC6, CDT1
cell cycle phase transition (GO:0044770)	-	4.24	0.0	CDT1, ORC1, CDC6, ORC4, ORC6
negative regulation of DNA replication (GO:0008156)	-	6.17	0.008	CDC6, GMNN
DNA replication (GO:0006260)	-	4.51	0.0	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
regulation of DNA replication (GO:0006275)	-	5.02	0.001	CDC6, CDT1, GMNN
cell cycle G1/S phase transition (GO:0044843)	-	5.12	0.0	CDT1, ORC1, CDC6, ORC4, ORC6
DNA metabolic process (GO:0006259)	-	3.09	0.0	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
cell cycle process (GO:0022402)	-	2.75	0.0	CDT1, ORC1, CDC6, ORC4, ORC6
DNA replication checkpoint (GO:0000076)	-	7.02	0.001	CDC6, CDT1
cell cycle (GO:0007049)	-	3.14	0.0	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
mitotic cell cycle (GO:0000278)	NEW	5.92	0.0	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
intracellular organelle part (GO:0044446)	0.81	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
intracellular membrane-bounded organelle (GO:0043231)	0.6	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
nucleus (GO:0005634)	1.07	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
cell part (GO:0044464)	0.11	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
nucleoplasm (GO:0005654)	1.89	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
intracellular organelle (GO:0043229)	0.51	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
nuclear part (GO:0044428)	1.55	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
intracellular part (GO:0044424)	0.28	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
membrane-bounded organelle (GO:0043227)	0.47	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
organelle (GO:0043226)	0.4	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
organelle part (GO:0044422)	0.79	6	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
cytoplasm (GO:0005737)	1.01	4	CDC6, ORC1, ORC4, GMNN
cytosol (GO:0005829)	1.68	4	CDC6, ORC1, CDT1, GMNN
cytoplasmic part (GO:0044444)	0.82	4	CDC6, ORC1, CDT1, GMNN
protein complex (GO:0043234)	1.51	3	ORC1, ORC4, ORC6
macromolecular complex (GO:0032991)	1.35	3	ORC1, ORC4, ORC6
origin recognition complex (GO:0000808)	7.61	3	ORC1, ORC4, ORC6
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	3	ORC1, ORC4, ORC6
nuclear chromosome part (GO:0044454)	3.67	3	ORC1, ORC4, ORC6
non-membrane-bounded organelle (GO:0043228)	1.76	3	ORC1, ORC4, ORC6
nuclear origin of replication recognition complex (GO:0005664)	7.61	3	ORC1, ORC4, ORC6
chromosomal part (GO:0044427)	3.18	3	ORC1, ORC4, ORC6
cytoskeleton (GO:0005856)	2.55	2	ORC4, ORC6
actin cytoskeleton (GO:0015629)	4.39	2	ORC4, ORC6
nucleolus (GO:0005730)	3.06	2	ORC1, ORC4
membrane (GO:0016020)	0.68	2	ORC1, ORC6
chromosome, telomeric region (GO:0000781)	4.9	2	ORC1, ORC4
nuclear chromosome, telomeric region (GO:0000784)	5.16	2	ORC1, ORC4
chromosomal region (GO:0098687)	4.19	2	ORC1, ORC4

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
origin recognition complex (GO:0000808)	-	7.61	0.0	ORC1, ORC4, ORC6
microtubule organizing center (GO:0005815)	NEW	3.42	0.046	CDC6, ORC1, CDT1, GMNN
nucleoplasm (GO:0005654)	-	1.89	0.001	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
nuclear chromosome part (GO:0044454)	-	3.67	0.0	CDC6, ORC1, ORC4, GMNN, ORC6
nuclear part (GO:0044428)	-	1.55	0.0	CDC6, ORC1, ORC6, CDT1, ORC4, GMNN
nuclear origin of replication recognition complex (GO:0005664)	-	7.61	0.0	ORC1, ORC4, ORC6
chromosomal part (GO:0044427)	-	3.18	0.002	CDC6, ORC1, ORC4, ORC6, GMNN