Disease table of HEMOLYTIC UREMIC SYNDROME OMIM ID: PS235400

Gene-disease associations table

GeneAssociated with HEMOLYTIC UREMIC SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
CFHR3OMIMHGNC link1q31.32PS235400, PS603075
CFHR1OMIMHGNC link1q31.32PS235400, PS603075
CFHClinVar, OMIM, HUMSAVARHGNC link1q31.34PS235400, 126700, 609814, PS603075
CFIClinVar, OMIM, HUMSAVARHGNC link4q253PS235400, 610984, PS603075
C3AR1ClinVarHGNC link12p13.311PS235400
CD46ClinVar, OMIM, HUMSAVARHGNC link1q32.21PS235400
BAATClinVarHGNC link9q31.12PS235400, 607748
C3ClinVar, OMIM, HUMSAVARHGNC link19p13.33PS235400, 613779, PS603075
THBDClinVar, OMIM, HUMSAVARHGNC link20p11.212PS235400, PS188050
CFBClinVar, OMIM, HUMSAVARHGNC link6p21.333PS235400, 615561, PS603075
DGKEClinVar, OMIM, HUMSAVARHGNC link17q222PS235400, PS256300

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Common tandem groupNumber of genes in this tandem group associated to this diseaseGenes in this tandem group associated to this disease
Group 862CFHR3, CFHR1
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
1q31.33CFH, CFHR3, CFHR1
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
1q313CFH, CFHR3, CFHR1
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
1q34CFH, CD46, CFHR3, CFHR1
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
1q4CFH, CD46, CFHR3, CFHR1
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
14CFH, CD46, CFHR3, CFHR1
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
STAT3NO129IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP122CFB, CD46
NFKB1NO306NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC62CFI, THBD
RELANO302NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC62CFI, THBD
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
CFHYES1SIRT10
CFIYES2NFKB1, RELA0
CD46YES1STAT30
C3YES1CEBPD0
THBDYES11SP1, RARB, EP300, KLF4, RARA, KLF2, RELA, PARP1, RXRA, NFKB1, RARG0
CFBYES2STAT3, CREB50
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
CFHR3CFHR1No1PRDX4
CFHR3CFHNo1C3
CFHR3CFINo1C3
CFHR3C3Yes0
CFHR3CFBNo1C3
CFHCFINo1C3
CFHC3Yes0
CFHCFBNo2ALB, C3
CFIC3Yes0
CFICFBNo1C3
C3CFBYes4DDX19B, GDPD1, CFP, FN1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
THBDCFBNo1PTEN

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
CFHCD46No1C3
CFHC3Yes2CFH, C3
CFHCFBNo1C3
CD46C3Yes2CD46, C3
CD46CFBNo1C3
C3CFBYes3CFD, CFB, C3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Complement and coagulation cascadeshsa046106.587CFI, C3AR1, CD46, C3, CFH, THBD, CFB
Staphylococcus aureus infectionhsa051506.645C3AR1, CFI, CFH, CFB, C3
Metabolic pathwayshsa011002.492DGKE, BAAT

NET-GE enrichment

Term New enriched termICP valueGenes
Pertussis (hsa05133) NEW6.460.03CFI, CD46, C3
Staphylococcus aureus infection (hsa05150) -6.640.0CFI, C3AR1, CD46, C3, CFH, CFB
Complement and coagulation cascades (hsa04610) -6.580.0CFI, C3AR1, CD46, C3, CFH, THBD, CFB
Immune systemNEW2.920.001CFI, C3AR1, CD46, C3, CFH, THBD, CFB
Infectious diseases: BacterialNEW3.760.009CFI, C3AR1, CD46, C3, CFH, CFB
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Complement cascadeR-HSA-1666585.386CFI, CD46, C3, CFH, CFB, CFHR3
Innate Immune SystemR-HSA-1682493.176CFI, CD46, C3, CFH, CFB, CFHR3
Regulation of Complement cascadeR-HSA-9776068.46CFI, CD46, C3, CFH, CFB, CFHR3
Immune SystemR-HSA-1682562.376CFI, CD46, C3, CFH, CFB, CFHR3
GPCR downstream signalingR-HSA-3883963.073C3AR1, DGKE, C3
Signal TransductionR-HSA-1625821.783C3AR1, DGKE, C3
Signaling by GPCRR-HSA-3727902.683C3AR1, DGKE, C3
G alpha (i) signalling eventsR-HSA-4185945.12C3AR1, C3
Class A/1 (Rhodopsin-like receptors)R-HSA-3730764.692C3AR1, C3
Peptide ligand-binding receptorsR-HSA-3752765.412C3AR1, C3
Alternative complement activationR-HSA-17373610.662CFB, C3
Activation of C3 and C5R-HSA-17457710.182CFB, C3
Initial triggering of complementR-HSA-1666635.512CFB, C3
GPCR ligand bindingR-HSA-5007924.192C3AR1, C3
HemostasisR-HSA-1095823.982DGKE, THBD

NET-GE enrichment

Term New enriched termICP valueGenes
Innate Immune System (R-HSA-168249) -3.170.008CFI, CD46, C3, CFH, CFB, CFHR3
Regulation of Complement cascade (R-HSA-977606) -8.40.0CFI, CD46, C3, CFH, CFB, CFHR3
Complement cascade (R-HSA-166658) -5.380.0CFI, CD46, C3, CFH, CFB, CFHR3
Activation of C3 and C5 (R-HSA-174577) -10.180.001CFB, C3
Alternative complement activation (R-HSA-173736) -10.660.0CFB, C3
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.189CFI, C3AR1, BAAT, CD46, C3, CFH, THBD, CFB, DGKE
protein binding (GO:0005515) 0.468CFI, C3AR1, BAAT, CD46, C3, CFH, THBD, CFB
catalytic activity (GO:0003824) 1.057CFI, C3AR1, CD46, BAAT, C3, CFB, DGKE
hydrolase activity (GO:0016787) 1.96CFI, C3AR1, CD46, BAAT, C3, CFB
molecular transducer activity (GO:0060089) 2.324C3AR1, CFI, CD46, THBD
peptidase activity (GO:0008233) 3.234CFB, CFI, CD46, C3
endopeptidase activity (GO:0004175) 3.634CFB, CFI, CD46, C3
receptor activity (GO:0004872) 2.324C3AR1, CFI, CD46, THBD
peptidase activity, acting on L-amino acid peptides (GO:0070011) 3.264CFB, CFI, CD46, C3
serine-type endopeptidase activity (GO:0004252) 4.43CFI, CFB, C3
cation binding (GO:0043169) 1.43CFI, DGKE, THBD
serine hydrolase activity (GO:0017171) 4.263CFI, CFB, C3
ion binding (GO:0043167) 1.363CFI, DGKE, THBD
complement binding (GO:0001848) 6.793C3AR1, CFB, CD46
metal ion binding (GO:0046872) 1.413CFI, DGKE, THBD
serine-type peptidase activity (GO:0008236) 4.273CFI, CFB, C3
signaling receptor activity (GO:0038023) 2.492C3AR1, THBD
carbohydrate derivative binding (GO:0097367) 2.032CFH, DGKE
enzyme regulator activity (GO:0030234) 2.852CD46, C3
transmembrane signaling receptor activity (GO:0004888) 2.572C3AR1, THBD
hydrolase activity, acting on ester bonds (GO:0016788) 3.12C3AR1, BAAT
transferase activity (GO:0016740) 1.952DGKE, BAAT
signal transducer activity (GO:0004871) 2.282C3AR1, THBD
enzyme inhibitor activity (GO:0004857) 3.782CD46, C3
molecular function regulator (GO:0098772) 2.512CD46, C3
receptor binding (GO:0005102) 2.432BAAT, C3
transmembrane receptor activity (GO:0099600) 2.532C3AR1, THBD

NET-GE enrichment

Term New enriched termICP valueGenes
serine-type endopeptidase activity (GO:0004252) -4.40.004CFB, CFI, CD46, C3
cargo receptor activity (GO:0038024) NEW5.530.0CFI, CFH, CD46, C3
complement binding (GO:0001848) -6.790.003CFB, CD46, C3
scavenger receptor activity (GO:0005044) NEW5.910.0CFI, CFH, CD46, C3
complement receptor activity (GO:0004875) NEW8.350.0C3AR1, C3
heparan sulfate proteoglycan binding (GO:0043395) NEW6.850.016CFH, C3
serine hydrolase activity (GO:0017171) -4.260.007CFB, CFI, CD46, C3
serine-type peptidase activity (GO:0008236) -4.270.006CFB, CFI, CD46, C3
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
biological regulation (GO:0065007) 0.399CFI, C3AR1, CD46, CFHR1, C3, CFH, THBD, CFB, DGKE
regulation of biological process (GO:0050789) 0.459CFI, C3AR1, CD46, CFHR1, C3, CFH, THBD, CFB, DGKE
primary metabolic process (GO:0044238) 0.698CFI, BAAT, CD46, CFHR1, C3, CFH, CFB, DGKE
response to stimulus (GO:0050896) 1.228CFI, C3AR1, CD46, CFHR1, C3, CFH, THBD, CFB
positive regulation of response to stimulus (GO:0048584) 2.188CFI, C3AR1, CD46, CFHR1, C3, CFH, THBD, CFB
regulation of response to stimulus (GO:0048583) 1.548CFI, C3AR1, CD46, CFHR1, C3, CFH, THBD, CFB
immune system process (GO:0002376) 2.298CFI, C3AR1, CD46, CFHR1, C3, CFH, THBD, CFB
organic substance metabolic process (GO:0071704) 0.638CFI, CD46, BAAT, CFHR1, C3, CFH, CFB, DGKE
metabolic process (GO:0008152) 0.588CFI, BAAT, CD46, CFHR1, C3, CFH, CFB, DGKE
positive regulation of biological process (GO:0048518) 1.28CFI, C3AR1, CD46, CFHR1, C3, CFH, THBD, CFB
regulation of immune response (GO:0050776) 2.987CFI, C3AR1, CD46, CFHR1, C3, CFH, CFB
regulation of response to external stimulus (GO:0032101) 3.067CFI, C3AR1, CD46, C3, CFH, THBD, CFB
regulation of response to stress (GO:0080134) 2.537CFI, C3AR1, CD46, C3, CFH, THBD, CFB
positive regulation of immune response (GO:0050778) 3.47CFI, C3AR1, CD46, CFHR1, C3, CFH, CFB
positive regulation of immune system process (GO:0002684) 2.967CFI, C3AR1, CD46, CFHR1, C3, CFH, CFB
regulation of immune system process (GO:0002682) 2.57CFI, C3AR1, CD46, CFHR1, C3, CFH, CFB
activation of immune response (GO:0002253) 3.677CFI, C3AR1, CD46, CFHR1, C3, CFH, CFB
immune response (GO:0006955) 2.867CFI, C3AR1, CD46, CFHR1, C3, CFH, CFB
regulation of complement activation (GO:0030449) 6.236CFI, C3AR1, CD46, C3, CFH, CFB
regulation of primary metabolic process (GO:0080090) 1.086CFI, C3AR1, CD46, C3, CFH, CFB
regulation of metabolic process (GO:0019222) 1.026CFI, C3AR1, CD46, C3, CFH, CFB
regulation of humoral immune response (GO:0002920) 5.826CFI, C3AR1, CD46, C3, CFH, CFB
single-organism process (GO:0044699) 0.486C3AR1, CD46, BAAT, C3, THBD, DGKE
protein activation cascade (GO:0072376) 5.216CFI, CD46, CFHR1, C3, CFH, CFB
regulation of protein metabolic process (GO:0051246) 1.936CFI, C3AR1, CD46, C3, CFH, CFB
regulation of inflammatory response (GO:0050727) 4.036CFI, C3AR1, CD46, C3, CFH, CFB
regulation of defense response (GO:0031347) 3.116CFI, C3AR1, CD46, C3, CFH, CFB
regulation of gene expression (GO:0010468) 1.376CFI, C3AR1, CD46, C3, CFH, CFB
regulation of macromolecule metabolic process (GO:0060255) 1.086CFI, C3AR1, CD46, C3, CFH, CFB
cellular process (GO:0009987) 0.266C3AR1, CD46, BAAT, C3, THBD, DGKE
regulation of protein activation cascade (GO:2000257) 6.176CFI, C3AR1, CD46, C3, CFH, CFB
defense response (GO:0006952) 2.786CFI, C3AR1, CD46, C3, CFH, CFB
response to stress (GO:0006950) 1.86CFI, C3AR1, CD46, C3, CFH, CFB
complement activation (GO:0006956) 5.496CFI, CD46, CFHR1, C3, CFH, CFB
regulation of acute inflammatory response (GO:0002673) 5.416CFI, C3AR1, CD46, C3, CFH, CFB
humoral immune response (GO:0006959) 4.596CFI, CD46, CFHR1, C3, CFH, CFB
regulation of protein processing (GO:0070613) 5.356CFI, C3AR1, CD46, C3, CFH, CFB
protein metabolic process (GO:0019538) 1.456CFI, CD46, CFHR1, C3, CFH, CFB
macromolecule metabolic process (GO:0043170) 0.836CFI, CD46, CFHR1, C3, CFH, CFB
regulation of immune effector process (GO:0002697) 3.716CFI, C3AR1, CD46, C3, CFH, CFB
immune effector process (GO:0002252) 3.586CFI, CD46, CFHR1, C3, CFH, CFB
regulation of proteolysis (GO:0030162) 3.26CFI, C3AR1, CD46, C3, CFH, CFB
regulation of protein maturation (GO:1903317) 5.336CFI, C3AR1, CD46, C3, CFH, CFB
innate immune response (GO:0045087) 3.555CFB, CFI, CFH, CD46, C3
single-organism cellular process (GO:0044763) 0.655C3AR1, BAAT, DGKE, THBD, C3
regulation of cellular process (GO:0050794) 0.55C3AR1, DGKE, CD46, THBD, C3
proteolysis (GO:0006508) 2.734CFB, CFI, CD46, C3
positive regulation of multicellular organismal process (GO:0051240) 2.494C3AR1, CD46, THBD, C3
multicellular organismal process (GO:0032501) 1.454C3AR1, CD46, THBD, C3
signal transduction (GO:0007165) 1.284C3AR1, DGKE, THBD, C3
regulation of multicellular organismal process (GO:0051239) 1.874C3AR1, CD46, THBD, C3
single-organism metabolic process (GO:0044710) 1.633DGKE, BAAT, C3
regulation of biological quality (GO:0065008) 1.683C3AR1, THBD, C3
positive regulation of metabolic process (GO:0009893) 1.743C3AR1, CD46, C3
single-multicellular organism process (GO:0044707) 1.783CD46, THBD, C3
positive regulation of developmental process (GO:0051094) 2.773C3AR1, CD46, C3
regulation of developmental process (GO:0050793) 2.13C3AR1, CD46, C3
lipid metabolic process (GO:0006629) 2.683DGKE, BAAT, C3
regulation of cellular metabolic process (GO:0031323) 1.073C3AR1, CD46, C3
positive regulation of macromolecule metabolic process (GO:0010604) 1.813C3AR1, CD46, C3
cellular metabolic process (GO:0044237) 0.693DGKE, BAAT, C3
regulation of cytokine production (GO:0001817) 3.43C3AR1, CD46, C3
positive regulation of response to external stimulus (GO:0032103) 4.173C3AR1, THBD, C3
complement activation, alternative pathway (GO:0006957) 7.163CFH, CFB, C3
negative regulation of biological process (GO:0048519) 1.333CD46, THBD, C3
regulation of multicellular organismal development (GO:2000026) 2.313C3AR1, CD46, C3
cellular lipid metabolic process (GO:0044255) 2.923DGKE, BAAT, C3
positive regulation of cytokine production (GO:0001819) 3.823C3AR1, CD46, C3
G-protein coupled receptor signaling pathway (GO:0007186) 2.643C3AR1, DGKE, C3
complement activation, classical pathway (GO:0006958) 5.743CFI, CD46, C3
negative regulation of cellular process (GO:0048523) 1.413CD46, THBD, C3
positive regulation of cellular process (GO:0048522) 1.33C3AR1, CD46, C3
regulation of cell proliferation (GO:0042127) 2.412C3AR1, CD46
fatty acid metabolic process (GO:0006631) 4.032BAAT, C3
negative regulation of metabolic process (GO:0009892) 1.932CD46, C3
regulation of anatomical structure morphogenesis (GO:0022603) 2.792C3AR1, C3
regulation of cell activation (GO:0050865) 3.532CD46, THBD
regulation of cellular biosynthetic process (GO:0031326) 1.382C3AR1, C3
negative regulation of response to stimulus (GO:0048585) 2.522CD46, THBD
blood coagulation (GO:0007596) 4.522THBD, C3
carboxylic acid metabolic process (GO:0019752) 3.122BAAT, C3
cellular biosynthetic process (GO:0044249) 1.372DGKE, BAAT
regulation of vasculature development (GO:1901342) 4.262C3AR1, C3
positive regulation of gene expression (GO:0010628) 2.352CD46, C3
small molecule metabolic process (GO:0044281) 2.382BAAT, C3
regulation of signaling (GO:0023051) 1.722CD46, C3
hemostasis (GO:0007599) 4.52THBD, C3
regulation of cell communication (GO:0010646) 1.732CD46, C3
negative regulation of catalytic activity (GO:0043086) 3.02CD46, C3
response to organic cyclic compound (GO:0014070) 3.072THBD, C3
response to endogenous stimulus (GO:0009719) 2.792THBD, C3
organic substance biosynthetic process (GO:1901576) 1.342DGKE, BAAT
negative regulation of protein metabolic process (GO:0051248) 2.822CD46, C3
positive regulation of vasculature development (GO:1904018) 4.832C3AR1, C3
negative regulation of macromolecule metabolic process (GO:0010605) 2.012CD46, C3
regulation of signal transduction (GO:0009966) 1.842CD46, C3
response to lipid (GO:0033993) 3.112THBD, C3
regulation of angiogenesis (GO:0045765) 4.362C3AR1, C3
positive regulation of angiogenesis (GO:0045766) 4.932C3AR1, C3
negative regulation of molecular function (GO:0044092) 2.742CD46, C3
regulation of molecular function (GO:0065009) 1.782CD46, C3
lipid biosynthetic process (GO:0008610) 3.492DGKE, BAAT
positive regulation of cellular metabolic process (GO:0031325) 1.812C3AR1, C3
positive regulation of cell proliferation (GO:0008284) 3.012C3AR1, CD46
locomotion (GO:0040011) 2.912C3AR1, THBD
negative regulation of cellular metabolic process (GO:0031324) 2.012CD46, C3
regulation of body fluid levels (GO:0050878) 3.762THBD, C3
regulation of catalytic activity (GO:0050790) 1.972CD46, C3
regulation of biosynthetic process (GO:0009889) 1.372C3AR1, C3
negative regulation of cellular protein metabolic process (GO:0032269) 2.882CD46, C3
monocarboxylic acid metabolic process (GO:0032787) 3.572BAAT, C3
reproductive process (GO:0022414) 2.552CD46, THBD
biosynthetic process (GO:0009058) 1.322DGKE, BAAT
single-organism biosynthetic process (GO:0044711) 2.82DGKE, BAAT
inflammatory response (GO:0006954) 3.642C3AR1, C3
oxoacid metabolic process (GO:0043436) 3.122BAAT, C3
response to chemical (GO:0042221) 1.982THBD, C3
regulation of localization (GO:0032879) 1.942C3AR1, C3
response to organic substance (GO:0010033) 2.22THBD, C3
multi-organism process (GO:0051704) 2.652CD46, THBD
response to oxygen-containing compound (GO:1901700) 2.572THBD, C3
tolerance induction (GO:0002507) 7.332C3AR1, C3
regulation of cellular protein metabolic process (GO:0032268) 1.992CD46, C3
organic acid metabolic process (GO:0006082) 3.012BAAT, C3
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002460) 5.572C3AR1, CD46
positive regulation of vascular endothelial growth factor production (GO:0010575) 6.472C3AR1, C3
regulation of vascular endothelial growth factor production (GO:0010574) 6.292C3AR1, C3
coagulation (GO:0050817) 4.512THBD, C3
adaptive immune response (GO:0002250) 4.432C3AR1, CD46
negative regulation of proteolysis (GO:0045861) 3.982CD46, C3
positive regulation of immune effector process (GO:0002699) 4.692CD46, C3

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of complement activation (GO:0030449) -6.230.0CFB, CFI, CFH, CD46, C3
regulation of response to external stimulus (GO:0032101) -3.060.0CFI, C3AR1, CD46, C3, CFH, THBD, CFB
positive regulation of response to stimulus (GO:0048584) -2.180.002CFI, C3AR1, CD46, CFHR1, C3, CFH, CFB
regulation of response to stimulus (GO:0048583) -1.540.009CFI, C3AR1, CD46, CFHR1, C3, CFH, THBD, CFB
negative regulation of humoral immune response (GO:0002921) NEW7.160.0CFI, CD46, C3
regulation of humoral immune response (GO:0002920) -5.820.0CFB, CFI, CFH, CD46, C3
regulation of defense response (GO:0031347) -3.110.002CFB, CFI, CFH, CD46, C3
regulation of phagocytosis (GO:0050764) NEW5.490.038CFI, CD46, C3
protein activation cascade (GO:0072376) -5.210.0CFI, CD46, CFHR1, C3, CFH, CFB
complement receptor mediated signaling pathway (GO:0002430) NEW8.120.005C3AR1, C3
regulation of inflammatory response (GO:0050727) -4.030.013CFB, CFI, CFH, CD46, C3
positive regulation of immune system process (GO:0002684) -2.960.013CFI, C3AR1, CD46, CFHR1, C3, CFH, CFB
regulation of immune system process (GO:0002682) -2.50.0CFI, C3AR1, CD46, CFHR1, C3, CFH, CFB
regulation of response to wounding (GO:1903034) NEW4.740.005CFI, CD46, C3, CFH, THBD, CFB
negative regulation of complement activation (GO:0045916) NEW7.430.0CFI, CD46, C3
negative regulation of protein activation cascade (GO:2000258) NEW7.330.0CFI, CD46, C3
innate immune response (GO:0045087) -3.550.012CFB, CFI, CFH, CD46, C3
regulation of protein activation cascade (GO:2000257) -6.170.0CFB, CFI, CFH, CD46, C3
defense response (GO:0006952) -2.780.009CFI, C3AR1, CD46, C3, CFH, CFB
regulation of protein processing (GO:0070613) -5.350.0CFB, CFI, CFH, CD46, C3
complement activation (GO:0006956) -5.490.0CFI, CD46, CFHR1, C3, CFH, CFB
complement activation, alternative pathway (GO:0006957) -7.160.0CFH, CFB, C3
immune response (GO:0006955) -2.860.005CFI, CD46, CFHR1, C3, CFH, CFB
regulation of acute inflammatory response (GO:0002673) -5.410.0CFB, CFI, CFH, CD46, C3
complement activation, classical pathway (GO:0006958) -5.740.03CFI, CD46, C3
humoral immune response (GO:0006959) -4.590.0CFI, C3AR1, CD46, CFHR1, C3, CFH, CFB
regulation of immune response (GO:0050776) -2.980.0CFI, C3AR1, CD46, CFHR1, C3, CFH, CFB
positive regulation vascular endothelial growth factor production (GO:0010575) -6.470.027C3AR1, C3
regulation of vascular endothelial growth factor production (GO:0010574) -6.290.037C3AR1, C3
positive regulation of immune response (GO:0050778) -3.40.0CFI, C3AR1, CD46, CFHR1, C3, CFH, CFB
immune system process (GO:0002376) -2.290.0CFI, C3AR1, CD46, CFHR1, C3, CFH, THBD, CFB
regulation of immune effector process (GO:0002697) -3.710.0CFB, CFI, CFH, CD46, C3
activation of immune response (GO:0002253) -3.670.0CFI, C3AR1, CD46, CFHR1, C3, CFH, CFB
immune effector process (GO:0002252) -3.580.0CFI, CD46, CFHR1, C3, CFH, CFB
regulation of protein maturation (GO:1903317) -5.330.0CFB, CFI, CFH, CD46, C3
regulation of response to stress (GO:0080134) -2.530.001CFI, CD46, C3, CFH, THBD, CFB
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
membrane-bounded organelle (GO:0043227) 0.478CFI, BAAT, CD46, CFHR1, C3, CFH, CFB, CFHR3
organelle (GO:0043226) 0.48CFI, BAAT, CD46, CFHR1, C3, CFH, CFB, CFHR3
extracellular region part (GO:0044421) 1.578CFI, CD46, CFHR1, C3, CFH, THBD, CFB, CFHR3
extracellular organelle (GO:0043230) 1.897CFI, CD46, CFHR1, C3, CFH, CFB, CFHR3
extracellular space (GO:0005615) 2.637CFI, CFHR1, C3, CFH, THBD, CFB, CFHR3
extracellular exosome (GO:0070062) 1.897CFI, CD46, CFHR1, C3, CFH, CFB, CFHR3
membrane (GO:0016020) 0.687CFI, C3AR1, CD46, C3, THBD, CFB, DGKE
cell part (GO:0044464) 0.117C3AR1, CD46, BAAT, C3, THBD, CFB, DGKE
membrane-bounded vesicle (GO:0031988) 1.717CFI, CD46, CFHR1, C3, CFH, CFB, CFHR3
extracellular vesicle (GO:1903561) 1.897CFI, CD46, CFHR1, C3, CFH, CFB, CFHR3
vesicle (GO:0031982) 1.647CFI, CD46, CFHR1, C3, CFH, CFB, CFHR3
extracellular region (GO:0005576) 2.186CFI, CFHR1, C3, CFH, CFB, CFHR3
plasma membrane (GO:0005886) 1.396C3AR1, CD46, C3, THBD, CFB, DGKE
blood microparticle (GO:0072562) 4.885CFHR1, CFH, CFHR3, CFB, C3
membrane part (GO:0044425) 0.954C3AR1, DGKE, CD46, THBD
integral component of membrane (GO:0016021) 1.144C3AR1, DGKE, CD46, THBD
intrinsic component of membrane (GO:0031224) 1.134C3AR1, DGKE, CD46, THBD
cytoplasm (GO:0005737) 1.013DGKE, BAAT, CD46
plasma membrane part (GO:0044459) 1.953C3AR1, CD46, THBD
intracellular part (GO:0044424) 0.283DGKE, BAAT, CD46
intrinsic component of plasma membrane (GO:0031226) 2.533C3AR1, CD46, THBD
integral component of plasma membrane (GO:0005887) 2.573C3AR1, CD46, THBD
intracellular membrane-bounded organelle (GO:0043231) 0.62BAAT, CD46
cell surface (GO:0009986) 3.442CD46, THBD
intracellular organelle (GO:0043229) 0.512BAAT, CD46
intracellular organelle part (GO:0044446) 0.812BAAT, CD46
cytoplasmic part (GO:0044444) 0.822BAAT, CD46
organelle part (GO:0044422) 0.792BAAT, CD46

NET-GE enrichment

Term New enriched termICP valueGenes
extracellular organelle (GO:0043230) -1.890.011CFI, CD46, CFHR1, C3, CFH, CFB, CFHR3
extracellular vesicular exosome (GO:0070062) -1.890.011CFI, CD46, CFHR1, C3, CFH, CFB, CFHR3
vesicle (GO:0031982) -1.640.035CFI, CD46, CFHR1, C3, CFH, CFB, CFHR3
blood microparticle (GO:0072562) -4.880.0CFI, C3AR1, CFHR1, C3, CFH, CFB, CFHR3
membrane-bounded vesicle (GO:0031988) -1.710.028CFI, CD46, CFHR1, C3, CFH, CFB, CFHR3
extracellular membrane-bounded organelle (GO:0065010) NEW8.70.011CFI, CD46, CFHR1, C3, CFH, CFB, CFHR3
extracellular region part (GO:0044421) -1.570.009CFI, CD46, CFHR1, C3, CFH, THBD, CFB, CFHR3
extracellular space (GO:0005615) -2.630.011CFI, CD46, CFHR1, C3, CFH, THBD, CFB, CFHR3