Disease table of LIPODYSTROPHY, FAMILIAL PARTIAL OMIM ID: PS151660

Gene-disease associations table

Gene	Associated with LIPODYSTROPHY, FAMILIAL PARTIAL in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
LIPE	OMIM	HGNC link	19q13.2	1	PS151660
PPP1R3A	OMIM	HGNC link	7q31.1	2	PS151660, 125853
PPARG	ClinVar, OMIM, HUMSAVAR	HGNC link	3p25.2	5	601665, PS137800, 125853, 609338, PS151660
LMNA	ClinVar, OMIM, HUMSAVAR	HGNC link	1q22	12	212112, PS310300, PS248370, PS176670, PS118220, PS604772, PS159000, PS115200, 613205, 275210, 610140, PS151660
CIDEC	ClinVar, OMIM	HGNC link	3p25.3	1	PS151660
PLIN1	ClinVar, OMIM	HGNC link	15q26.1	1	PS151660

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
3p25	2	PPARG, CIDEC

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
3p2	2	PPARG, CIDEC

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
3p	2	PPARG, CIDEC

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
3	2	PPARG, CIDEC

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
PPARG	YES	69	BCL2L1, EGFR, PLIN2, TNFRSF11B, CPT1B, DEFB103A, NOTCH4, VLDLR, SAT1, TP53, DBI, CAV1, CIDEA, PDK2, SERPINE1, CFLAR, ATP2A2, STAT6, ICAM1, TXNIP, FABP4, PTGS2, JAG1, CCNE1, GDF15, CEBPA, KLF5, GK, APOBR, ERO1L, RETN, CD83, TG, AGER, CAT, CSF1, POU2F1, BCL2, REN, UGT1A9, CDKN1A, CLDN2, ERP44, RARB, ANGPTL4, ADIPOQ, SOCS7, PTEN, BAD, SLC2A4, FGF1, SLC9A1, CD36, ABCG2, MMP1, BRS3, NR1H3, TSHR, LIPE, SLC5A5, ACAT1, MMP9, APOB, HMOX1, CIITA, MYC, CCND1, KLF4, FASLG	1	LIPE
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	2	PLIN1, LIPE
RELA	NO	302	NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC6	2	PLIN1, LIPE

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
LIPE	YES	3	PPARG, NFKB1, RELA	1	PPARG
PPARG	YES	14	NCOR1, UHRF1, SREBF1, EGR1, SREBF2, CDX1, RB1, CEBPD, SIRT1, NR4A3, KLF2, E2F1, GATA2, STAT1	0
PLIN1	YES	2	NFKB1, RELA	0

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
LIPE	PLIN1	Yes	1	PLIN1
PPP1R3A	PPARG	No	1	ZFYVE9
PPP1R3A	LMNA	No	4	MKI67, TOX4, NUP50, RIF1
PPARG	LMNA	No	9	USP7, CTNNB1, PML, XRCC6, SVIL, RB1, PRKCA, UBE2I, KAT5
LMNA	CIDEC	No	1	VCP

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
LIPE	PPARG	No	-	4	PRKAA2, PLIN1, PRKAA1, FABP4
LIPE	CIDEC	No	-	1	PLIN1
LIPE	PLIN1	Yes	binding	3	PRKACG, PRKACA, PRKACB
PPP1R3A	PPARG	No	-	1	INS
PPP1R3A	PLIN1	No	-	2	INS, PPP1CC
PPARG	CIDEC	No	-	1	PLIN1
PPARG	PLIN1	Yes	activation, binding	41	NRIP1, MED24, MED13, MED10, CDK19, MED9, MED30, HELZ2, CDK8, MED19, MED8, MED27, MED20, MED31, EP300, NCOA3, CCNC, MED25, MED12, PNPLA2, MED18, PPARGC1A, MED17, NCOA2, MED15, MED26, MED23, MED13L, MED1, MED11, TRIB3, MED6, MED14, MED4, MED29, MED16, INS, MED21, NCOA1, CREBBP, MED7
CIDEC	PLIN1	Yes	binding	0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
PPAR signaling pathway	hsa03320	6.56	2	PLIN1, PPARG
Insulin signaling pathway	hsa04910	5.55	2	PPP1R3A, LIPE
AMPK signaling pathway	hsa04152	5.8	2	PPARG, LIPE

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Insulin signaling pathway (hsa04910)	-	5.55	0.047	PPP1R3A, PLIN1, LIPE
PPAR signaling pathway (hsa03320)	-	6.56	0.025	PLIN1, PPARG
Endocrine system	NEW	3.26	0.012	PLIN1, PPP1R3A, PPARG, LIPE
cAMP signaling pathway (hsa04024)	NEW	5.05	0.004	PLIN1, PPP1R3A, PPARG, LIPE

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Metabolism of lipids and lipoproteins	R-HSA-556833	3.79	3	PLIN1, PPARG, LIPE
Metabolism	R-HSA-1430728	2.34	3	PLIN1, PPARG, LIPE
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	6.7	2	PLIN1, PPARG
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis	R-HSA-163560	8.66	2	PLIN1, LIPE
Developmental Biology	R-HSA-1266738	3.48	2	PLIN1, PPARG
Lipid digestion, mobilization, and transport	R-HSA-73923	7.2	2	PLIN1, LIPE

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Transcriptional regulation of white adipocyte differentiation (R-HSA-381340)	-	6.7	0.019	PLIN1, PPARG
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (R-HSA-163560)	-	8.66	0.0	PLIN1, PPARG, LIPE
Lipid digestion, mobilization, and transport (R-HSA-73923)	-	7.2	0.009	PLIN1, PPARG, LIPE

GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	4	PLIN1, PPARG, LIPE, LMNA
protein binding (GO:0005515)	0.46	3	PPARG, LIPE, LMNA
enzyme binding (GO:0019899)	2.27	3	PPARG, LIPE, LMNA
protein phosphatase binding (GO:0019903)	4.93	2	PPARG, LMNA
phosphatase binding (GO:0019902)	4.63	2	PPARG, LMNA
lipid binding (GO:0008289)	3.26	2	PLIN1, PPARG

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
single-organism process (GO:0044699)	0.48	6	PPP1R3A, PPARG, PLIN1, LIPE, LMNA, CIDEC
organic substance metabolic process (GO:0071704)	0.63	5	CIDEC, PPP1R3A, PPARG, PLIN1, LIPE
cellular process (GO:0009987)	0.26	5	CIDEC, PPP1R3A, PPARG, LIPE, LMNA
single-organism cellular process (GO:0044763)	0.65	5	CIDEC, PPP1R3A, PPARG, LIPE, LMNA
metabolic process (GO:0008152)	0.58	5	CIDEC, PPP1R3A, PPARG, PLIN1, LIPE
primary metabolic process (GO:0044238)	0.69	5	CIDEC, PPP1R3A, PPARG, PLIN1, LIPE
single-organism metabolic process (GO:0044710)	1.63	4	PLIN1, PPP1R3A, PPARG, LIPE
cellular metabolic process (GO:0044237)	0.69	4	CIDEC, PPP1R3A, PPARG, LIPE
cellular macromolecule metabolic process (GO:0044260)	0.93	4	CIDEC, PPP1R3A, PPARG, LIPE
macromolecule metabolic process (GO:0043170)	0.83	4	CIDEC, PPP1R3A, PPARG, LIPE
lipid metabolic process (GO:0006629)	2.68	3	PLIN1, PPARG, LIPE
regulation of cellular process (GO:0050794)	0.5	3	CIDEC, PPARG, LMNA
regulation of programmed cell death (GO:0043067)	2.49	3	CIDEC, PPARG, LMNA
biological regulation (GO:0065007)	0.39	3	CIDEC, PPARG, LMNA
regulation of cell death (GO:0010941)	2.43	3	CIDEC, PPARG, LMNA
regulation of apoptotic process (GO:0042981)	2.5	3	CIDEC, PPARG, LMNA
regulation of biological process (GO:0050789)	0.45	3	CIDEC, PPARG, LMNA
organic cyclic compound metabolic process (GO:1901360)	1.26	3	CIDEC, PPARG, LIPE
regulation of primary metabolic process (GO:0080090)	1.08	2	CIDEC, PPARG
regulation of metabolic process (GO:0019222)	1.02	2	CIDEC, PPARG
negative regulation of response to stimulus (GO:0048585)	2.52	2	PPARG, LMNA
regulation of response to stimulus (GO:0048583)	1.54	2	PPARG, LMNA
signal transduction (GO:0007165)	1.28	2	PPARG, LMNA
organic cyclic compound biosynthetic process (GO:1901362)	1.66	2	CIDEC, PPARG
cellular component organization or biogenesis (GO:0071840)	1.22	2	CIDEC, LMNA
cellular response to stimulus (GO:0051716)	1.97	2	PPARG, LMNA
negative regulation of signal transduction (GO:0009968)	2.75	2	PPARG, LMNA
regulation of signal transduction (GO:0009966)	1.84	2	PPARG, LMNA
cellular developmental process (GO:0048869)	1.82	2	PPARG, LMNA
response to mechanical stimulus (GO:0009612)	4.41	2	PPARG, LMNA
animal organ development (GO:0048513)	2.53	2	PPARG, LMNA
positive regulation of biological process (GO:0048518)	1.2	2	PPARG, LMNA
negative regulation of biological process (GO:0048519)	1.33	2	PPARG, LMNA
macromolecule localization (GO:0033036)	2.34	2	PPARG, LMNA
regulation of macromolecule metabolic process (GO:0060255)	1.08	2	CIDEC, PPARG
monocarboxylic acid metabolic process (GO:0032787)	3.57	2	PPARG, LIPE
establishment of protein localization (GO:0045184)	2.53	2	PPARG, LMNA
regulation of RNA biosynthetic process (GO:2001141)	1.55	2	CIDEC, PPARG
oxoacid metabolic process (GO:0043436)	3.12	2	PPARG, LIPE
oxidation-reduction process (GO:0055114)	2.91	2	PPP1R3A, PPARG
heterocycle metabolic process (GO:0046483)	1.31	2	CIDEC, PPARG
single organism reproductive process (GO:0044702)	2.73	2	PPARG, LMNA
response to external stimulus (GO:0009605)	2.55	2	PPARG, LMNA
cellular biosynthetic process (GO:0044249)	1.37	2	CIDEC, PPARG
protein metabolic process (GO:0019538)	1.45	2	PPARG, LIPE
cellular response to stress (GO:0033554)	2.51	2	PPARG, LMNA
aromatic compound biosynthetic process (GO:0019438)	1.7	2	CIDEC, PPARG
small molecule metabolic process (GO:0044281)	2.38	2	PPARG, LIPE
cellular response to chemical stimulus (GO:0070887)	2.57	2	PPARG, LMNA
nitrogen compound metabolic process (GO:0006807)	1.13	2	CIDEC, PPARG
nucleic acid-templated transcription (GO:0097659)	1.91	2	CIDEC, PPARG
organic substance biosynthetic process (GO:1901576)	1.34	2	CIDEC, PPARG
cellular component organization (GO:0016043)	1.24	2	CIDEC, LMNA
cellular response to oxygen levels (GO:0071453)	4.97	2	PPARG, LMNA
heterocycle biosynthetic process (GO:0018130)	1.7	2	CIDEC, PPARG
regulation of developmental process (GO:0050793)	2.1	2	PPARG, LMNA
transport (GO:0006810)	1.51	2	PPARG, LMNA
regulation of biosynthetic process (GO:0009889)	1.37	2	CIDEC, PPARG
response to stress (GO:0006950)	1.8	2	PPARG, LMNA
regulation of multicellular organismal process (GO:0051239)	1.87	2	PPARG, LMNA
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	2	CIDEC, PPARG
establishment of localization (GO:0051234)	1.48	2	PPARG, LMNA
RNA metabolic process (GO:0016070)	1.59	2	CIDEC, PPARG
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	2	CIDEC, PPARG
response to stimulus (GO:0050896)	1.22	2	PPARG, LMNA
single-organism transport (GO:0044765)	2.18	2	PPARG, LMNA
regulation of transcription, DNA-templated (GO:0006355)	1.56	2	CIDEC, PPARG
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	2	CIDEC, PPARG
transcription, DNA-templated (GO:0006351)	1.91	2	CIDEC, PPARG
fatty acid metabolic process (GO:0006631)	4.03	2	PPARG, LIPE
RNA biosynthetic process (GO:0032774)	1.84	2	CIDEC, PPARG
regulation of cellular component organization (GO:0051128)	2.01	2	PPARG, LMNA
negative regulation of signaling (GO:0023057)	2.65	2	PPARG, LMNA
cellular nitrogen compound metabolic process (GO:0034641)	1.22	2	CIDEC, PPARG
negative regulation of cell communication (GO:0010648)	2.66	2	PPARG, LMNA
cellular macromolecule biosynthetic process (GO:0034645)	1.66	2	CIDEC, PPARG
regulation of signaling (GO:0023051)	1.72	2	PPARG, LMNA
regulation of cell communication (GO:0010646)	1.73	2	PPARG, LMNA
nucleobase-containing compound metabolic process (GO:0006139)	1.35	2	CIDEC, PPARG
positive regulation of multicellular organismal process (GO:0051240)	2.49	2	PPARG, LMNA
negative regulation of multicellular organismal process (GO:0051241)	2.84	2	PPARG, LMNA
developmental process (GO:0032502)	1.36	2	PPARG, LMNA
cellular aromatic compound metabolic process (GO:0006725)	1.3	2	CIDEC, PPARG
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	2	CIDEC, PPARG
positive regulation of cell differentiation (GO:0045597)	3.01	2	PPARG, LMNA
regulation of cell differentiation (GO:0045595)	2.42	2	PPARG, LMNA
cellular lipid metabolic process (GO:0044255)	2.92	2	PPARG, LIPE
regulation of localization (GO:0032879)	1.94	2	PPARG, LMNA
organic acid metabolic process (GO:0006082)	3.01	2	PPARG, LIPE
positive regulation of developmental process (GO:0051094)	2.77	2	PPARG, LMNA
regulation of RNA metabolic process (GO:0051252)	1.52	2	CIDEC, PPARG
regulation of cellular biosynthetic process (GO:0031326)	1.38	2	CIDEC, PPARG
regulation of cellular metabolic process (GO:0031323)	1.07	2	CIDEC, PPARG
carboxylic acid metabolic process (GO:0019752)	3.12	2	PPARG, LIPE
nucleic acid metabolic process (GO:0090304)	1.46	2	CIDEC, PPARG
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	2	CIDEC, PPARG
organic substance transport (GO:0071702)	2.15	2	PPARG, LMNA
regulation of gene expression (GO:0010468)	1.37	2	CIDEC, PPARG
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	2	CIDEC, PPARG
single-organism developmental process (GO:0044767)	1.49	2	PPARG, LMNA
reproductive process (GO:0022414)	2.55	2	PPARG, LMNA
biosynthetic process (GO:0009058)	1.32	2	CIDEC, PPARG
macromolecule biosynthetic process (GO:0009059)	1.61	2	CIDEC, PPARG
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	2	CIDEC, PPARG
response to chemical (GO:0042221)	1.98	2	PPARG, LMNA
localization (GO:0051179)	1.4	2	PPARG, LMNA
single-organism localization (GO:1902578)	2.09	2	PPARG, LMNA
response to oxygen levels (GO:0070482)	4.02	2	PPARG, LMNA
organelle organization (GO:0006996)	2.02	2	CIDEC, LMNA
response to abiotic stimulus (GO:0009628)	2.8	2	PPARG, LMNA
anatomical structure development (GO:0048856)	1.58	2	PPARG, LMNA
regulation of multicellular organismal development (GO:2000026)	2.31	2	PPARG, LMNA
negative regulation of cellular process (GO:0048523)	1.41	2	PPARG, LMNA
positive regulation of cellular process (GO:0048522)	1.3	2	PPARG, LMNA

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
triglyceride metabolic process (GO:0006641)	NEW	5.41	0.037	PLIN1, PPARG, LIPE
triglyceride catabolic process (GO:0019433)	NEW	6.68	0.007	PLIN1, PPARG, LIPE
long-chain fatty acid metabolic process (GO:0001676)	NEW	5.27	0.04	PPARG, LIPE, LMNA
acylglycerol catabolic process (GO:0046464)	NEW	6.47	0.009	PLIN1, PPARG, LIPE
glycerolipid catabolic process (GO:0046503)	NEW	6.15	0.016	PLIN1, PPARG, LIPE
neutral lipid catabolic process (GO:0046461)	NEW	6.47	0.009	PLIN1, PPARG, LIPE

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
intracellular part (GO:0044424)	0.28	5	CIDEC, PLIN1, PPARG, LIPE, LMNA
cytoplasmic part (GO:0044444)	0.82	5	CIDEC, PLIN1, PPARG, LIPE, LMNA
intracellular organelle (GO:0043229)	0.51	5	CIDEC, PLIN1, PPARG, LIPE, LMNA
cell part (GO:0044464)	0.11	5	CIDEC, PLIN1, PPARG, LIPE, LMNA
organelle (GO:0043226)	0.4	5	CIDEC, PLIN1, PPARG, LIPE, LMNA
cytosol (GO:0005829)	1.68	4	CIDEC, PPARG, LIPE, LMNA
membrane (GO:0016020)	0.68	4	PPP1R3A, PLIN1, LIPE, LMNA
membrane-bounded organelle (GO:0043227)	0.47	4	CIDEC, PLIN1, PPARG, LMNA
intracellular membrane-bounded organelle (GO:0043231)	0.6	4	CIDEC, PLIN1, PPARG, LMNA
cytoplasm (GO:0005737)	1.01	3	PPARG, LIPE, LMNA
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	3	PLIN1, CIDEC, LIPE
nucleus (GO:0005634)	1.07	3	CIDEC, PPARG, LMNA
lipid particle (GO:0005811)	5.66	3	PLIN1, CIDEC, LIPE
non-membrane-bounded organelle (GO:0043228)	1.76	3	PLIN1, CIDEC, LIPE
membrane part (GO:0044425)	0.95	3	PPP1R3A, PLIN1, LIPE
intracellular organelle part (GO:0044446)	0.81	2	PPARG, LMNA
endoplasmic reticulum (GO:0005783)	2.56	2	PLIN1, CIDEC
integral component of membrane (GO:0016021)	1.14	2	PPP1R3A, PLIN1
nucleoplasm (GO:0005654)	1.89	2	PPARG, LMNA
nuclear part (GO:0044428)	1.55	2	PPARG, LMNA
organelle part (GO:0044422)	0.79	2	PPARG, LMNA
perinuclear region of cytoplasm (GO:0048471)	3.35	2	PPARG, LMNA
intrinsic component of membrane (GO:0031224)	1.13	2	PPP1R3A, PLIN1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
cytosol (GO:0005829)	-	1.68	0.01	CIDEC, PLIN1, PPARG, LIPE, LMNA
lipid particle (GO:0005811)	-	5.66	0.0	CIDEC, PLIN1, PPARG, LIPE