Disease table of RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISORDER OMIM ID: 614470

Gene-disease associations table

GeneAssociated with RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISORDER inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
NRASClinVar, OMIM, HUMSAVARHGNC link1p13.28137550, PS163950, 249400, 163200, 607785, 114500, 614470, 162900
KRASClinVar, OMIMHGNC link12p12.114601626, 600268, 137215, 109800, PS163950, 211980, 114480, PS115150, 613659, 163200, 607785, 614470, 162900, 260350

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
NRASYES1AR0
KRASYES1MYC0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
NRASKRASNo6RGL2, RAP1GDS1, ELAVL1, PIK3CG, RAF1, EEF1A1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
NRASKRASYesRAF1-RAS complex, EGF induced2HRAS, RAF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
KRASNRASmaybe, indirectThey are members of the same protein family.
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Signaling pathways regulating pluripotency of stem cellshsa045505.62KRAS, NRAS
Bladder cancerhsa052197.382KRAS, NRAS
Endometrial cancerhsa052136.812KRAS, NRAS
Renal cell carcinomahsa052116.62KRAS, NRAS
Thyroid cancerhsa052167.482KRAS, NRAS
Melanomahsa052186.562KRAS, NRAS
Gliomahsa052146.662KRAS, NRAS
Prostate cancerhsa052156.112KRAS, NRAS
Tight junctionhsa045305.532KRAS, NRAS
Long-term potentiationhsa047206.642KRAS, NRAS
Neurotrophin signaling pathwayhsa047225.782KRAS, NRAS
Cholinergic synapsehsa047255.882KRAS, NRAS
Choline metabolism in cancerhsa052316.092KRAS, NRAS
FoxO signaling pathwayhsa040685.632KRAS, NRAS
Serotonergic synapsehsa047265.842KRAS, NRAS
Chemokine signaling pathwayhsa040625.192KRAS, NRAS
Oxytocin signaling pathwayhsa049215.42KRAS, NRAS
Natural killer cell mediated cytotoxicityhsa046505.532KRAS, NRAS
HTLV-I infectionhsa051664.592KRAS, NRAS
Regulation of actin cytoskeletonhsa048104.92KRAS, NRAS
Hepatitis Chsa051605.682KRAS, NRAS
Hepatitis Bhsa051615.522KRAS, NRAS
B cell receptor signaling pathwayhsa046626.522KRAS, NRAS
Gap junctionhsa045406.242KRAS, NRAS
VEGF signaling pathwayhsa043706.772KRAS, NRAS
Proteoglycans in cancerhsa052055.022KRAS, NRAS
Estrogen signaling pathwayhsa049156.112KRAS, NRAS
MicroRNAs in cancerhsa052065.382KRAS, NRAS
Pathways in cancerhsa052003.982KRAS, NRAS
Viral carcinogenesishsa052035.082KRAS, NRAS
T cell receptor signaling pathwayhsa046606.012KRAS, NRAS
Insulin signaling pathwayhsa049105.552KRAS, NRAS
Ras signaling pathwayhsa040144.92KRAS, NRAS
Non-small cell lung cancerhsa052236.882KRAS, NRAS
Prolactin signaling pathwayhsa049176.62KRAS, NRAS
Acute myeloid leukemiahsa052216.742KRAS, NRAS
Chronic myeloid leukemiahsa052206.482KRAS, NRAS
Thyroid hormone signaling pathwayhsa049195.822KRAS, NRAS
Long-term depressionhsa047306.742KRAS, NRAS
PI3K-Akt signaling pathwayhsa041514.212KRAS, NRAS
GnRH signaling pathwayhsa049126.182KRAS, NRAS
MAPK signaling pathwayhsa040104.632KRAS, NRAS
Rap1 signaling pathwayhsa040154.972KRAS, NRAS
Melanogenesishsa049165.972KRAS, NRAS
Alcoholismhsa050345.592KRAS, NRAS
Axon guidancehsa043605.632KRAS, NRAS
Central carbon metabolism in cancerhsa052306.72KRAS, NRAS
Fc epsilon RI signaling pathwayhsa046646.62KRAS, NRAS
ErbB signaling pathwayhsa040126.152KRAS, NRAS

NET-GE enrichment

Term New enriched termICP valueGenes
Signaling pathways regulating pluripotency of stem cells (hsa04550) -5.60.03KRAS, NRAS
Bladder cancer (hsa05219) -7.380.003KRAS, NRAS
Endometrial cancer (hsa05213) -6.810.006KRAS, NRAS
Renal cell carcinoma (hsa05211) -6.60.016KRAS, NRAS
Thyroid cancer (hsa05216) -7.480.003KRAS, NRAS
Melanoma (hsa05218) -6.560.017KRAS, NRAS
Glioma (hsa05214) -6.660.007KRAS, NRAS
Prostate cancer (hsa05215) -6.110.015KRAS, NRAS
Tight junction (hsa04530) -5.530.033KRAS, NRAS
Long-term potentiation (hsa04720) -6.640.014KRAS, NRAS
Neurotrophin signaling pathway (hsa04722) -5.780.023KRAS, NRAS
Central carbon metabolism in cancer (hsa05230) -6.70.006KRAS, NRAS
Choline metabolism in cancer (hsa05231) -6.090.05KRAS, NRAS
FoxO signaling pathway (hsa04068) -5.630.029KRAS, NRAS
Serotonergic synapse (hsa04726) -5.840.022KRAS, NRAS
Oxytocin signaling pathway (hsa04921) -5.40.04KRAS, NRAS
Cholinergic synapse (hsa04725) -5.880.02KRAS, NRAS
Natural killer cell mediated cytotoxicity (hsa04650) -5.530.033KRAS, NRAS
Hepatitis C (hsa05160) -5.680.027KRAS, NRAS
Hepatitis B (hsa05161) -5.520.034KRAS, NRAS
Gap junction (hsa04540) -6.240.037KRAS, NRAS
VEGF signaling pathway (hsa04370) -6.770.01KRAS, NRAS
Estrogen signaling pathway (hsa04915) -6.110.015KRAS, NRAS
MicroRNAs in cancer (hsa05206) -5.380.041KRAS, NRAS
GnRH signaling pathway (hsa04912) -6.180.013KRAS, NRAS
B cell receptor signaling pathway (hsa04662) -6.520.017KRAS, NRAS
Non-small cell lung cancer (hsa05223) -6.880.005KRAS, NRAS
ErbB signaling pathway (hsa04012) -6.150.024KRAS, NRAS
Acute myeloid leukemia (hsa05221) -6.740.006KRAS, NRAS
Chronic myeloid leukemia (hsa05220) -6.480.009KRAS, NRAS
Thyroid hormone signaling pathway (hsa04919) -5.820.022KRAS, NRAS
Long-term depression (hsa04730) -6.740.017KRAS, NRAS
T cell receptor signaling pathway (hsa04660) -6.010.043KRAS, NRAS
Insulin signaling pathway (hsa04910) -5.550.032KRAS, NRAS
Melanogenesis (hsa04916) -5.970.045KRAS, NRAS
Alcoholism (hsa05034) -5.590.031KRAS, NRAS
Axon guidance (hsa04360) -5.630.029KRAS, NRAS
Fc epsilon RI signaling pathway (hsa04664) -6.60.013KRAS, NRAS
Prolactin signaling pathway (hsa04917) -6.60.021KRAS, NRAS
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Interleukin-2 signalingR-HSA-4519275.052KRAS, NRAS
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.622KRAS, NRAS
Developmental BiologyR-HSA-12667383.482KRAS, NRAS
Signaling by VEGFR-HSA-1941384.662KRAS, NRAS
FCERI mediated MAPK activationR-HSA-28717964.322KRAS, NRAS
IRS-mediated signallingR-HSA-1123994.872KRAS, NRAS
Signaling by Ligand-Responsive EGFR Variants in CancerR-HSA-56378158.732KRAS, NRAS
Constitutive Signaling by EGFRvIIIR-HSA-56378109.082KRAS, NRAS
Signaling by EGFRvIII in CancerR-HSA-56378129.082KRAS, NRAS
VEGFA-VEGFR2 PathwayR-HSA-44200974.72KRAS, NRAS
Signaling by FGFR1 in diseaseR-HSA-56553027.812KRAS, NRAS
Downstream signaling of activated FGFR3R-HSA-56547084.712KRAS, NRAS
SOS-mediated signallingR-HSA-1124125.152KRAS, NRAS
Tie2 SignalingR-HSA-2109938.812KRAS, NRAS
Downstream signaling of activated FGFR4R-HSA-56547164.712KRAS, NRAS
SHC-mediated cascade:FGFR4R-HSA-56547198.462KRAS, NRAS
VEGFR2 mediated cell proliferationR-HSA-52189215.072KRAS, NRAS
Immune SystemR-HSA-1682562.372KRAS, NRAS
Frs2-mediated activationR-HSA-1709685.122KRAS, NRAS
Downstream signal transductionR-HSA-1867634.652KRAS, NRAS
RAF activationR-HSA-56730008.342KRAS, NRAS
RAF/MAP kinase cascadeR-HSA-56730015.152KRAS, NRAS
Signalling to p38 via RIT and RINR-HSA-1877065.122KRAS, NRAS
FRS-mediated FGFR2 signalingR-HSA-56547005.142KRAS, NRAS
FRS-mediated FGFR4 signalingR-HSA-56547125.142KRAS, NRAS
FRS-mediated FGFR3 signalingR-HSA-56547065.142KRAS, NRAS
SHC-mediated cascade:FGFR3R-HSA-56547048.812KRAS, NRAS
Activation of RAS in B cellsR-HSA-116909210.662KRAS, NRAS
Signaling by EGFR in CancerR-HSA-16437138.732KRAS, NRAS
Signaling by FGFR in diseaseR-HSA-12260997.492KRAS, NRAS
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.032KRAS, NRAS
Interleukin receptor SHC signalingR-HSA-9125265.092KRAS, NRAS
Innate Immune SystemR-HSA-1682493.172KRAS, NRAS
Signaling by ERBB2R-HSA-12279864.662KRAS, NRAS
SHC-related events triggered by IGF1RR-HSA-24289339.812KRAS, NRAS
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.512KRAS, NRAS
Prolonged ERK activation eventsR-HSA-1698935.112KRAS, NRAS
Signaling by FGFR2R-HSA-56547384.682KRAS, NRAS
GRB2 events in EGFR signalingR-HSA-1798125.152KRAS, NRAS
Signaling by FGFR1R-HSA-56547364.692KRAS, NRAS
DAP12 interactionsR-HSA-21721274.562KRAS, NRAS
EGFR Transactivation by GastrinR-HSA-21793929.812KRAS, NRAS
Axon guidanceR-HSA-4224753.932KRAS, NRAS
Signaling by FGFR2 in diseaseR-HSA-56552538.232KRAS, NRAS
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.262KRAS, NRAS
Signaling by FGFR3 in diseaseR-HSA-56553328.522KRAS, NRAS
Signaling by LeptinR-HSA-25865525.12KRAS, NRAS
MAP2K and MAPK activationR-HSA-56741357.662KRAS, NRAS
IGF1R signaling cascadeR-HSA-24289244.852KRAS, NRAS
IRS-related events triggered by IGF1RR-HSA-24289284.852KRAS, NRAS
Signaling by Insulin receptorR-HSA-747524.732KRAS, NRAS
DiseaseR-HSA-16436853.332KRAS, NRAS
Insulin receptor signalling cascadeR-HSA-747514.852KRAS, NRAS
Downstream signaling of activated FGFR1R-HSA-56546874.712KRAS, NRAS
SHC-mediated cascade:FGFR1R-HSA-56546888.592KRAS, NRAS
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.592KRAS, NRAS
C-type lectin receptors (CLRs)R-HSA-56214816.062KRAS, NRAS
Diseases of signal transductionR-HSA-56632024.892KRAS, NRAS
GRB2 events in ERBB2 signalingR-HSA-19636405.152KRAS, NRAS
Signalling to RASR-HSA-1670445.082KRAS, NRAS
SHC-mediated cascade:FGFR2R-HSA-56546998.282KRAS, NRAS
Downstream signaling of activated FGFR2R-HSA-56546964.712KRAS, NRAS
SHC1 events in EGFR signalingR-HSA-1803365.152KRAS, NRAS
FRS-mediated FGFR1 signalingR-HSA-56546935.142KRAS, NRAS
SHC1 events in ERBB2 signalingR-HSA-12501965.152KRAS, NRAS
Signaling by EGFRR-HSA-1779294.592KRAS, NRAS
ARMS-mediated activationR-HSA-1709845.122KRAS, NRAS
CD209 (DC-SIGN) signalingR-HSA-56215758.592KRAS, NRAS
SHC1 events in ERBB4 signalingR-HSA-12503475.152KRAS, NRAS
Signaling by PDGFR-HSA-1867974.532KRAS, NRAS
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.852KRAS, NRAS
p38MAPK eventsR-HSA-1710079.282KRAS, NRAS
Signaling by InterleukinsR-HSA-4491474.712KRAS, NRAS
Cell surface interactions at the vascular wallR-HSA-2027336.322KRAS, NRAS
Cytokine Signaling in Immune systemR-HSA-12802153.742KRAS, NRAS
Signaling by ERBB4R-HSA-12363944.72KRAS, NRAS
MAPK1/MAPK3 signalingR-HSA-56849965.112KRAS, NRAS
Adaptive Immune SystemR-HSA-12802183.192KRAS, NRAS
MAPK family signaling cascadesR-HSA-56830574.892KRAS, NRAS
Signalling by NGFR-HSA-1665204.232KRAS, NRAS
Signaling by FGFR4R-HSA-56547434.692KRAS, NRAS
Signaling by FGFR3R-HSA-56547414.692KRAS, NRAS
Signaling by FGFRR-HSA-1902364.672KRAS, NRAS
Signaling by SCF-KITR-HSA-14335574.732KRAS, NRAS
NCAM signaling for neurite out-growthR-HSA-3751654.92KRAS, NRAS
DAP12 signalingR-HSA-24244914.642KRAS, NRAS
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.992KRAS, NRAS
Constitutive Signaling by Ligand-Responsive EGFR Cancer VariantsR-HSA-12363828.732KRAS, NRAS
Negative regulation of MAPK pathwayR-HSA-56752217.662KRAS, NRAS
Regulation of RAS by GAPsR-HSA-56584426.922KRAS, NRAS
Signaling by GPCRR-HSA-3727902.682KRAS, NRAS
Signalling to ERKsR-HSA-1876875.042KRAS, NRAS
Signaling by FGFR4 in diseaseR-HSA-56552919.522KRAS, NRAS
HemostasisR-HSA-1095823.982KRAS, NRAS
Signal TransductionR-HSA-1625821.782KRAS, NRAS

NET-GE enrichment

Term New enriched termICP valueGenes
p38MAPK events (R-HSA-171007) -9.280.0KRAS, NRAS
Signaling by FGFR3 in disease (R-HSA-5655332) -8.520.001KRAS, NRAS
MAP2K and MAPK activation (R-HSA-5674135) -7.660.005KRAS, NRAS
Cell surface interactions at the vascular wall (R-HSA-202733) -6.320.049KRAS, NRAS
RAF activation (R-HSA-5673000) -8.340.001KRAS, NRAS
SHC-mediated cascade:FGFR1 (R-HSA-5654688) -8.590.001KRAS, NRAS
Signaling by Ligand-Responsive EGFR Variants in Cancer (R-HSA-5637815) -8.730.001KRAS, NRAS
Constitutive Signaling by EGFRvIII (R-HSA-5637810) -9.080.0KRAS, NRAS
SHC-mediated cascade:FGFR3 (R-HSA-5654704) -8.810.001KRAS, NRAS
Signaling by EGFRvIII in Cancer (R-HSA-5637812) -9.080.0KRAS, NRAS
Activation of RAS in B cells (R-HSA-1169092) -10.660.0KRAS, NRAS
Signaling by EGFR in Cancer (R-HSA-1643713) -8.730.001KRAS, NRAS
Signaling by FGFR in disease (R-HSA-1226099) -7.490.007KRAS, NRAS
C-type lectin receptors (CLRs) (R-HSA-5621481) -6.060.021KRAS, NRAS
Downstream signaling events of B Cell Receptor (BCR) (R-HSA-1168372) -5.590.041KRAS, NRAS
Signaling by FGFR1 in disease (R-HSA-5655302) -7.810.002KRAS, NRAS
EGFR Transactivation by Gastrin (R-HSA-2179392) -9.810.0KRAS, NRAS
SHC-related events triggered by IGF1R (R-HSA-2428933) -9.810.0KRAS, NRAS
SHC-mediated cascade:FGFR2 (R-HSA-5654699) -8.280.001KRAS, NRAS
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (R-HSA-1236382) -8.730.001KRAS, NRAS
Negative regulation of MAPK pathway (R-HSA-5675221) -7.660.004KRAS, NRAS
Regulation of RAS by GAPs (R-HSA-5658442) -6.920.007KRAS, NRAS
CD209 (DC-SIGN) signaling (R-HSA-5621575) -8.590.001KRAS, NRAS
Signaling by FGFR4 in disease (R-HSA-5655291) -9.520.0KRAS, NRAS
Tie2 Signaling (R-HSA-210993) -8.810.0KRAS, NRAS
SHC-mediated cascade:FGFR4 (R-HSA-5654719) -8.460.001KRAS, NRAS
Signaling by FGFR2 in disease (R-HSA-5655253) -8.230.001KRAS, NRAS
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
ribonucleotide binding (GO:0032553) 2.192KRAS, NRAS
purine ribonucleoside binding (GO:0032550) 2.222KRAS, NRAS
guanyl nucleotide binding (GO:0019001) 3.732KRAS, NRAS
purine ribonucleoside triphosphate binding (GO:0035639) 2.222KRAS, NRAS
carbohydrate derivative binding (GO:0097367) 2.032KRAS, NRAS
organic cyclic compound binding (GO:0097159) 1.052KRAS, NRAS
nucleoside phosphate binding (GO:1901265) 1.962KRAS, NRAS
nucleotide binding (GO:0000166) 1.962KRAS, NRAS
small molecule binding (GO:0036094) 1.892KRAS, NRAS
guanyl ribonucleotide binding (GO:0032561) 3.732KRAS, NRAS
purine ribonucleotide binding (GO:0032555) 2.22KRAS, NRAS
macromolecular complex binding (GO:0044877) 2.612KRAS, NRAS
binding (GO:0005488) 0.182KRAS, NRAS
protein binding (GO:0005515) 0.462KRAS, NRAS
ribonucleoside binding (GO:0032549) 2.222KRAS, NRAS
protein complex binding (GO:0032403) 3.092KRAS, NRAS
purine nucleotide binding (GO:0017076) 2.192KRAS, NRAS
GTP binding (GO:0005525) 3.782KRAS, NRAS
heterocyclic compound binding (GO:1901363) 1.062KRAS, NRAS
purine nucleoside binding (GO:0001883) 2.222KRAS, NRAS
nucleoside binding (GO:0001882) 2.212KRAS, NRAS

NET-GE enrichment

Term New enriched termICP valueGenes
SH3/SH2 adaptor activity (GO:0005070) NEW5.790.005KRAS, NRAS
guanyl ribonucleotide binding (GO:0032561) -3.730.017KRAS, NRAS
signaling adaptor activity (GO:0035591) NEW5.430.008KRAS, NRAS
guanyl nucleotide binding (GO:0019001) -3.730.017KRAS, NRAS
GTP binding (GO:0005525) -3.780.015KRAS, NRAS
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
phosphorylation (GO:0016310) 2.632KRAS, NRAS
positive regulation of response to stimulus (GO:0048584) 2.182KRAS, NRAS
regulation of response to stimulus (GO:0048583) 1.542KRAS, NRAS
movement of cell or subcellular component (GO:0006928) 2.612KRAS, NRAS
positive regulation of defense response (GO:0031349) 3.832KRAS, NRAS
leukocyte migration (GO:0050900) 4.192KRAS, NRAS
signal transduction (GO:0007165) 1.282KRAS, NRAS
cell surface receptor signaling pathway (GO:0007166) 2.092KRAS, NRAS
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242KRAS, NRAS
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.542KRAS, NRAS
intracellular signal transduction (GO:0035556) 2.392KRAS, NRAS
regulation of biological process (GO:0050789) 0.452KRAS, NRAS
regulation of defense response (GO:0031347) 3.112KRAS, NRAS
cellular protein metabolic process (GO:0044267) 1.632KRAS, NRAS
single-organism metabolic process (GO:0044710) 1.632KRAS, NRAS
small GTPase mediated signal transduction (GO:0007264) 3.852KRAS, NRAS
immune response-regulating signaling pathway (GO:0002764) 3.722KRAS, NRAS
cellular macromolecule metabolic process (GO:0044260) 0.932KRAS, NRAS
immune response-regulating cell surface receptor signaling pathway (GO:0002768) 3.962KRAS, NRAS
MAPK cascade (GO:0000165) 3.912KRAS, NRAS
Ras protein signal transduction (GO:0007265) 4.762KRAS, NRAS
organic substance metabolic process (GO:0071704) 0.632KRAS, NRAS
positive regulation of immune system process (GO:0002684) 2.962KRAS, NRAS
regulation of immune system process (GO:0002682) 2.52KRAS, NRAS
single-organism process (GO:0044699) 0.482KRAS, NRAS
positive regulation of biological process (GO:0048518) 1.22KRAS, NRAS
biological regulation (GO:0065007) 0.392KRAS, NRAS
signal transduction by protein phosphorylation (GO:0023014) 3.792KRAS, NRAS
cell migration (GO:0016477) 3.122KRAS, NRAS
innate immune response activating cell surface receptor signaling pathway (GO:0002220) 5.072KRAS, NRAS
stimulatory C-type lectin receptor signaling pathway (GO:0002223) 5.092KRAS, NRAS
protein phosphorylation (GO:0006468) 2.892KRAS, NRAS
cellular process (GO:0009987) 0.262KRAS, NRAS
positive regulation of innate immune response (GO:0045089) 4.222KRAS, NRAS
regulation of innate immune response (GO:0045088) 3.862KRAS, NRAS
regulation of immune response (GO:0050776) 2.982KRAS, NRAS
cellular protein modification process (GO:0006464) 1.792KRAS, NRAS
regulation of cellular process (GO:0050794) 0.52KRAS, NRAS
macromolecule modification (GO:0043412) 1.732KRAS, NRAS
immune response-activating signal transduction (GO:0002757) 3.82KRAS, NRAS
epidermal growth factor receptor signaling pathway (GO:0007173) 5.722KRAS, NRAS
innate immune response-activating signal transduction (GO:0002758) 4.452KRAS, NRAS
metabolic process (GO:0008152) 0.582KRAS, NRAS
Fc-epsilon receptor signaling pathway (GO:0038095) 4.842KRAS, NRAS
ERBB2 signaling pathway (GO:0038128) 6.092KRAS, NRAS
neuron projection guidance (GO:0097485) 4.432KRAS, NRAS
locomotion (GO:0040011) 2.912KRAS, NRAS
primary metabolic process (GO:0044238) 0.692KRAS, NRAS
immune response-activating cell surface receptor signaling pathway (GO:0002429) 4.062KRAS, NRAS
Fc receptor signaling pathway (GO:0038093) 4.452KRAS, NRAS
cell motility (GO:0048870) 3.022KRAS, NRAS
protein metabolic process (GO:0019538) 1.452KRAS, NRAS
regulation of response to stress (GO:0080134) 2.532KRAS, NRAS
axon guidance (GO:0007411) 4.442KRAS, NRAS
positive regulation of immune response (GO:0050778) 3.42KRAS, NRAS
cellular metabolic process (GO:0044237) 0.692KRAS, NRAS
macromolecule metabolic process (GO:0043170) 0.832KRAS, NRAS
immune system process (GO:0002376) 2.292KRAS, NRAS
activation of innate immune response (GO:0002218) 4.412KRAS, NRAS
phosphate-containing compound metabolic process (GO:0006796) 2.162KRAS, NRAS
protein modification process (GO:0036211) 1.792KRAS, NRAS
activation of immune response (GO:0002253) 3.672KRAS, NRAS
phosphorus metabolic process (GO:0006793) 2.152KRAS, NRAS
single-organism cellular process (GO:0044763) 0.652KRAS, NRAS
ERBB signaling pathway (GO:0038127) 5.362KRAS, NRAS

NET-GE enrichment

Term New enriched termICP valueGenes
activation of MAPKK activity (GO:0000186) NEW5.740.029KRAS, NRAS
visual behavior (GO:0007632) NEW5.820.002KRAS, NRAS
regulation of Ras protein signal transduction (GO:0046578) NEW4.490.01KRAS, NRAS
positive regulation of Ras protein signal transduction (GO:0046579) NEW6.20.001KRAS, NRAS
branching morphogenesis of an epithelial tube (GO:0048754) NEW4.930.017KRAS, NRAS
regulation of synaptic transmission (GO:0050804) NEW4.090.049KRAS, NRAS
cellular response to insulin stimulus (GO:0032869) NEW5.290.032KRAS, NRAS
leukocyte migration (GO:0050900) -4.190.042KRAS, NRAS
regulation of neuron apoptotic process (GO:0043523) NEW4.470.031KRAS, NRAS
regulation of Rac protein signal transduction (GO:0035020) NEW7.240.0KRAS, NRAS
ERBB signaling pathway (GO:0038127) -5.360.032KRAS, NRAS
positive regulation of Rac protein signal transduction (GO:0035022) NEW8.630.0KRAS, NRAS
striated muscle cell differentiation (GO:0051146) NEW5.690.002KRAS, NRAS
learning or memory (GO:0007611) NEW4.330.035KRAS, NRAS
fibroblast growth factor receptor signaling pathway (GO:0008543) NEW5.30.023KRAS, NRAS
regulation of neuronal synaptic plasticity (GO:0048168) NEW5.840.028KRAS, NRAS
signal transduction by phosphorylation (GO:0023014) -3.790.037KRAS, NRAS
regulation of long-term neuronal synaptic plasticity (GO:0048169) NEW6.550.001KRAS, NRAS
MAPK cascade (GO:0000165) -3.910.026KRAS, NRAS
cellular response to fibroblast growth factor stimulus (GO:0044344) NEW6.40.029KRAS, NRAS
visual learning (GO:0008542) NEW5.920.002KRAS, NRAS
epithelial tube branching involved in lung morphogenesis (GO:0060441) NEW6.90.0KRAS, NRAS
positive regulation of small GTPase mediated signal transduction (GO:0051057) NEW6.040.001KRAS, NRAS
insulin receptor signaling pathway (GO:0008286) NEW5.330.019KRAS, NRAS
morphogenesis of a branching epithelium (GO:0061138) NEW4.770.022KRAS, NRAS
learning (GO:0007612) NEW4.850.012KRAS, NRAS
associative learning (GO:0008306) NEW5.440.003KRAS, NRAS
epidermal growth factor receptor signaling pathway (GO:0007173) -5.720.031KRAS, NRAS
Ras protein signal transduction (GO:0007265) -4.760.018KRAS, NRAS
negative regulation of neuron death (GO:1901215) NEW4.570.019KRAS, NRAS
regulation of neuron death (GO:1901214) NEW4.190.04KRAS, NRAS
cognition (GO:0050890) NEW4.20.046KRAS, NRAS
regulation of synaptic plasticity (GO:0048167) NEW4.780.012KRAS, NRAS
regulation of synaptic transmission, GABAergic (GO:0032228) NEW6.360.001KRAS, NRAS
morphogenesis of a branching structure (GO:0001763) NEW4.710.024KRAS, NRAS
response to fibroblast growth factor (GO:0071774) NEW6.170.03KRAS, NRAS
negative regulation of neuron apoptotic process (GO:0043524) NEW4.820.015KRAS, NRAS
muscle cell differentiation (GO:0042692) NEW5.090.012KRAS, NRAS
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.62KRAS, NRAS
membrane (GO:0016020) 0.682KRAS, NRAS
cell part (GO:0044464) 0.112KRAS, NRAS
cytoplasmic part (GO:0044444) 0.822KRAS, NRAS
intracellular (GO:0005622) 2.372KRAS, NRAS
intracellular organelle (GO:0043229) 0.512KRAS, NRAS
plasma membrane (GO:0005886) 1.392KRAS, NRAS
intracellular part (GO:0044424) 0.282KRAS, NRAS
membrane-bounded organelle (GO:0043227) 0.472KRAS, NRAS
organelle (GO:0043226) 0.42KRAS, NRAS