Disease table of BREAST CANCER OMIM ID: 114480

Gene-disease associations table

Gene	Associated with BREAST CANCER in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
TSG101	OMIM	HGNC link	11p15.1	1	114480
HMMR	OMIM	HGNC link	5q34	1	114480
ATM	OMIM	HGNC link	11q22.3	2	208900, 114480
NQO2	OMIM	HGNC link	6p25.2	1	114480
AKT1	OMIM, HUMSAVAR	HGNC link	14q32.33	6	167000, 176920, 114480, 181500, 114500, PS158350
BRIP1	OMIM, HUMSAVAR	HGNC link	17q23.2	2	PS227650, 114480
XRCC3	OMIM	HGNC link	14q32.33	2	PS155600, 114480
RB1CC1	OMIM	HGNC link	8q11.23	1	114480
PPM1D	OMIM	HGNC link	17q23.2	1	114480
RAD54L	OMIM	HGNC link	1p34.1	2	605027, 114480
FAM175A	HUMSAVAR	HGNC link	4q21.23	1	114480
NBN	HUMSAVAR	HGNC link	8q21.3	4	609135, 613065, 114480, 251260
CDH1	OMIM	HGNC link	16q22.1	5	608089, 167000, 176807, 137215, 114480
CHEK2	OMIM, HUMSAVAR	HGNC link	22q12.1	4	PS151623, 176807, 259500, 114480
BRCA1	HUMSAVAR	HGNC link	17q21.31	5	PS227650, 167000, 614320, PS604370, 114480
BRCA2	OMIM, HUMSAVAR	HGNC link	13q13.1	8	PS227650, PS194070, 155255, 114480, 176807, PS137800, 613347, PS604370
BARD1	OMIM	HGNC link	2q35	1	114480
BCPR	OMIM	HGNC link	17-	1	114480
KRAS	OMIM	HGNC link	12p12.1	14	601626, 600268, 137215, 109800, PS163950, 211980, 114480, PS115150, 613659, 163200, 607785, 614470, 162900, 260350
TP53	OMIM	HGNC link	17p13.1	12	114550, 260500, 605027, PS137800, 614740, 114480, 260350, 607107, 202300, 114500, PS151623, 259500
SLC22A18	OMIM	HGNC link	11p15.4	3	114480, 268210, 211980
ESR1	OMIM	HGNC link	6q25.1	4	608446, 157300, 615363, 114480
PHB	OMIM	HGNC link	17q21.33	1	114480
PALB2	OMIM	HGNC link	16p12.2	3	PS227650, 114480, 613348
CASP8	OMIM	HGNC link	2q33.1	4	114550, 607271, 211980, 114480
RAD51	OMIM, HUMSAVAR	HGNC link	15q15.1	2	PS157600, 114480
PIK3CA	OMIM, HUMSAVAR	HGNC link	3q26.32	11	114550, PS158350, 167000, 612918, 211980, 114480, 602501, 114500, 182000, 162900, 613659

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
17q23.2	2	BRIP1, PPM1D
14q32.33	2	AKT1, XRCC3

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
17q21	2	BRCA1, PHB
14q32	2	AKT1, XRCC3
17q23	2	BRIP1, PPM1D
11p15	2	TSG101, SLC22A18

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
17q2	4	BRCA1, BRIP1, PPM1D, PHB
2q3	2	BARD1, CASP8
11p1	2	TSG101, SLC22A18
14q3	2	AKT1, XRCC3

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
2q	2	BARD1, CASP8
14q	2	AKT1, XRCC3
11p	2	TSG101, SLC22A18
8q	2	RB1CC1, NBN
17q	4	BRCA1, BRIP1, PPM1D, PHB

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
11	3	TSG101, SLC22A18, ATM
14	2	AKT1, XRCC3
17	5	BRCA1, TP53, BRIP1, PPM1D, PHB
16	2	CDH1, PALB2
2	2	BARD1, CASP8
6	2	NQO2, ESR1
8	2	RB1CC1, NBN

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
TSG101	YES	3	REG4, EGFR, MDM2	0
ATM	YES	21	PVR, SP1, CDKN1A, BAX, MCL1, FOXM1, BCL2, FAS, TERF1, IGF1R, TNFRSF10B, SLC2A1, TP53, GADD45A, KLRK1, PMAIP1, DUSP1, CFLAR, VEGFA, HIPK2, MTF1	1	TP53
BRIP1	YES	1	BARD1	1	BARD1
RB1CC1	YES	1	RB1	0
BRCA1	YES	52	ATM, RNASEL, DDIT3, KRT5, JAK2, MAD2L1, IRF7, EGFR, HSPA5, FOS, XPC, STAT2, EGR1, CCND1, AREG, FST, HNRNPA2B1, STAT1, CASR, E2F6, ESR1, SIRT1, DDB2, CDKN1A, KRT18, CXCL1, FOXC1, FOXC2, IFNA1, CDH3, CYP1A1, CTSD, IGF1, KHSRP, CYP19A1, HMGA2, EP300, KRT17, TFF1, STAT3, BRCA2, ASPM, TP63, IGF1R, GADD45A, JAK1, CDKN1B, CCNB1, MYC, VEGFA, IRF9, HIF1A	3	ATM, BRCA2, ESR1
BARD1	YES	1	ESR1	1	ESR1
TP53	YES	159	ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING1	6	BRCA2, ESR1, TP53, AKT1, BRCA1, CHEK2
ESR1	YES	68	UGT2B15, AR, PELP1, EGFR, FLT1, RET, AVP, NRF1, CDK4, SERPINE1, PGR, FOS, VEGFA, CHAT, RUNX2, ZFHX3, CYP19A1, SERPINB9, TYMS, DCT, CXCL12, PTMA, HTRA2, NR5A2, CD24, HSPB1, CYP1B1, CTNNB1, MMP13, BRCA1, CYP2C19, BLM, OXT, TAC3, CCNA2, ZEB1, CDKN1A, STAT5A, TERT, MDM2, PMAIP1, CYP1A1, RARA, TP53, JUN, CDH1, AMH, CRHBP, MYC, TFF1, E2F1, CRH, KDR, BTG2, BCL2, UGT1A4, TGFA, KRT19, F12, FOXP1, ESRRA, GREB1, CTSD, JUNB, ESR1, YWHAQ, CCND1, CDKN1B	4	BRCA1, ESR1, TP53, CDH1
RAD51	YES	1	HR	0
DNMT1	NO	24	MBD2, BIRC5, IL32, CDKN2A, CDKN2B, TIMP3, CASP8, PROM1, CXCR4, BAG1, TERT, GAD1, TNFRSF10B, CDH1, VEGFA, RELN, EPCAM, MGMT, IL3, KIR2DL3, RUNX3, RB1, BMP2, MSH2	2	CASP8, CDH1
MYC	NO	102	CBFB, PRDX3, CHKA, ATF3, CDK4, PCNA, CEBPA, LDHA, DKK1, MTDH, TFAP4, HLA-G, CDC25A, UBE2C, HLA-B, GATA1, TP53, BAG2, PMAIP1, CDK6, WRN, PGK1, TFAM, IGK, JUNB, ZFP36, HNRNPA1, MYB, SART3, EBNA1BP2, TOP1MT, ST3GAL4, CD33, CCND2, PTBP1, CDCA7, RB1, CCNA2, HLA-C, CYP3A4, FMR1, TERT, NFE2, MME, NDRG1, HDAC2, BRD7, FASLG, CCNB1, TP73, RCC1, SFRP1, HLA-F, CFLAR, BCAT1, CD38, TFRC, CCND1, MTA1, KRAS, HNRNPA2B1, CDC34, ST3GAL3, HLA-A, FUT3, NOL7, FTH1P18, VEGFA, EP300, CDK2, ASS1, SURF1, CDC25C, IER3, ST3GAL1, FOXM1, HSPA4, XPO1, CAD, SHMT1, DDX18, IGF2BP1, BMI1, IPO7, BCL2, CXCR4, SRSF1, TLX1, PRODH, NBN, CDKN1A, IFNA1, TNFRSF10B, ID2, CCNE1, SURF2, HLA-E, CREBBP, MAPK1, IL6, EIF4E, ODC1	3	NBN, KRAS, TP53
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	4	ATM, BRCA1, ESR1, NQO2
KLF4	NO	30	ATF3, IVL, GDF15, KRT19, BIRC5, TP53, MMP2, BDKRB2, IFITM3, GPA33, CCND1, LAMA3, THBD, ALPI, IL1B, CDKN1A, VDR, CDH1, RARA, NANOG, HDC, LXN, CYP1A1, HSPA8, CDKN1C, IL6, CDKN1B, CCNB1, ODC1, CDH5	2	TP53, CDH1
CREB1	NO	90	NDC80, NRF1, IFNG, NR2F1, CYP19A1, CASP8, LDHA, SMAD6, SLC19A1, GSK3A, IL10, PSEN1, PPP2R2B, JUN, HPGD, IL2, GABPA, MC2R, CRTC1, AR, FLT1, SLC39A1, BDKRB2, NPY, PTGS2, MSMB, CFTR, HMOX1, MITF, AQP3, MUC5AC, STMN1, TRH, PCSK1, MMP2, CYP17A1, NOLC1, PRL, NMNAT2, TLR9, NTS, PLAT, FOS, BCL2L11, MUC4, GSK3B, CYP11B1, PPM1D, CCK, ETV3, PTGES, UXT, HLA-DOB, CGA, XPC, ACACA, SLC22A8, TH, VIP, BDKRB1, CYP11B2, POLD2, LAPTM4B, SOX9, PLAU, SNAI1, PPP2CA, SNAI2, SPRY2, HLA-DQB1, CCL5, CXCR4, ADRA1A, NR5A2, ERBB2, GRPR, BDNF, NR4A3, IL5RA, SLC20A1, RRM2B, LYL1, BCL2, CD4, NR2F6, NF1, IL6, CYP11A1, ODC1, FOXA1	2	PPM1D, CASP8
GATA3	NO	33	IL12RB2, KLK1, CHST4, IFNG, EPO, ERVW-1, TEK, MUC1, CD40LG, HSD17B1, TRA, ERG, ESR1, FUT7, ZEB1, CDH3, CDX2, FOXC1, FOXC2, PAEP, IL10, CDH1, MMP1, CD8A, DLC1, CXCL1, GATA3, IL4, IL5, EPOR, CD8B, STAT4, MYCN	2	ESR1, CDH1
CTBP1	NO	4	BRCA2, BRCA1, CLDN7, KRT18	2	BRCA1, BRCA2
ID4	NO	2	BRCA1, ESR1	2	BRCA1, ESR1
VDR	NO	36	DKK4, CST5, PRL, LRP5, IGFBP3, BGLAP, EGFR, TPT1, IL12B, SKP2, PHB, CYP7A1, RUNX2, TNFRSF21, CYP1A1, ERBB2, CD14, CYP24A1, CYP3A4, CDKN1B, FOXP3, PODXL, IL10, HOXA10, CDH1, CALB1, SPP1, AMH, TRPV6, DDIT4, CXCL8, IL2, PTH, IL6, CAMP, TNFSF11	2	PHB, CDH1
JUN	NO	155	PTN, TXN, ATF3, MEF2D, SMN1, TP53, MMP2, SPRR1B, EDN1, TNFRSF1B, NQO1, ELN, CYP19A1, GJA1, MAP3K1, ACTA1, STAR, NEIL1, ALOX12, PPARA, LOR, SLC19A1, NOS2, IFNB1, IL1B, MGMT, FGF7, JUN, ETS2, GSTP1, PCK2, BECN1, ITGB8, MMP3, CREM, IL23A, HEY1, FOSL1, CCL2, TERT, NAMPT, FASLG, BCL2L1, EGFR, RUNX2, CDKN1A, EZH2, MYB, DCN, NPY, PLAT, RARG, PTGS2, MAPK8, CCND2, NGF, TFF1, TNF, LBP, NFKB2, CYP2J2, NOX5, BEX2, NOS3, RARA, MMP1, F3, ETS1, ABCB1, STMN1, PLAUR, TNFRSF10A, IBSP, DDX21, TP73, SPRR3, PPARD, UGT2B15, RARB, IFNG, IL12A, AR, OPRM1, REN, NTS, MSR1, SYK, FOS, APP, CDK5R1, ITGAX, CCND1, CCK, PDK1, CYP1A2, BRCA1, CTSL, MMP20, MAT2A, PDHA1, SPP1, TIMP2, OXTR, VEGFA, SOX7, RHOB, CA2, IL24, CXCL8, IL2, EZR, IL1A, APOC3, MMP9, FGL2, NEFL, SOD2, BATF3, POLD2, FIGF, PLAU, DDIT3, PENK, PGR, IL12B, LGALS3, RELB, LDHA, CCL5, FAS, SMAD7, GCLC, MMP7, CD82, CYP11A1, MGP, ATG5, CSF2, SPI1, VDR, MFI2, MMP12, CTGF, IL5RA, VCAM1, CSF1, TNC, APOM, IL3, CD69, IL6, MMP13, CSTA, KRT16, MYC	2	BRCA1, TP53
SIRT1	NO	43	ACAN, TBX3, ESRRG, EZH2, CFLAR, NR1I2, FOXO3, SELE, HSF1, ABCB1, TP73, CCND1, NR5A2, CFH, HYOU1, IL1B, SHC1, COL1A2, NBN, CDKN1A, CTNNB1, MCL1, TNFRSF10B, BCL11A, CDH1, PARP1, ICAM1, PAX6, DLL4, SIRT6, NOTCH1, WRN, ADAMTS5, NDRG1, PER1, TNF, MMP9, COL10A1, TP53, EGLN1, MYC, PPARG, HIF1A	3	NBN, TP53, CDH1
PARP1	NO	25	FN1, SNAI1, IFNAR1, IFNG, VIM, SERPINE1, TERF2, TCF4, THBD, FOXO1, E2F1, CDKN1A, SMARCB1, CDH1, SH3BP2, FBN1, IL10, RELA, NFKB1, CXCL1, BRCA2, BCL2, HTR1A, JUN, SERPINF1	2	BRCA2, CDH1
CREBBP	NO	27	ALOX15, CLOCK, CSF2, TP53, CREB1, EGFR, PTGS2, IL4, LDHA, INSM1, HOXA9, CCK, ONECUT1, BRCA1, PPARA, RS1, CDKN1A, RARA, TRIM22, NPAS2, EP300, PCK2, HOXA10, IRF1, PSMC5, HINFP, RAD51	3	BRCA1, RAD51, TP53
HDAC1	NO	64	NFYA, PSIP1, RECK, EIF2AK1, RARB, BIRC3, IGFBP3, CD1D, HSPA5, FOS, CDKN2A, TXNIP, PTGS2, RUNX3, NOS3, RHOB, MICA, EGR1, FAS, KLF4, CLDN7, HMGCS1, CD44, CCND2, MICB, CD82, RECQL4, GRIN2B, SP1, SERPINB5, PHB, BIRC5, COMP, CDC25A, ESR1, FSHR, HOXA9, AR, GAD1, RELN, KLK3, CDH1, SPP1, TP53, PCNA, CXCL8, ICAM1, MGMT, TFF1, EPCAM, STAT3, BRCA2, ABCB1, BCL2A1, SNAI2, HLA-DRA, CDKN1A, MMP28, MMP9, TJP1, TERT, IL2, CCND1, CDKN1B	5	PHB, ESR1, BRCA2, TP53, CDH1
HDAC2	NO	22	TWIST1, SNAI2, CAD, CCL2, CD1D, SP1, CCNE1, MUC5AC, KLF4, BMP7, PHB, CDKN1A, PRDX2, IGF1, TNFSF10, CDH1, CXCL8, ALOX5, APAF1, GRM2, MYC, MYCN	2	PHB, CDH1
YY1	NO	74	FCER1A, CFTR, EGFR, GDAP1, POSTN, TP53, ATP2C1, IFNG, ADORA2A, KIR3DL1, TOP3A, HBE1, LDLR, SERPINE1, LRIG2, HSPA5, GBP1, HLA-DRA, APC, HAS2, CCL13, SNRPN, FMO3, TFRC, CTCF, FAS, TF, CXCR4, FCGR3B, DNAJB4, HSD3B2, ERBB2, SURF1, TDO2, IVL, BRCA1, DEK, COX7C, CETP, ERCC5, NOS2, BDKRB1, SLC26A3, EPAS1, ACTC1, ZNF175, BAP1, TNFRSF10B, HOXB7, NF1, OPRM1, PCNA, PARP1, PRDM2, VWF, TP73, CCR5, CBX5, SURF2, IL4, NR3C1, PDIA6, CYP3A5, CREBBP, HCFC1, IL5, DBH, RB1, FDPS, FCGR2B, LSS, MYC, HOXB13, COL1A2	2	BRCA1, TP53
HDAC9	NO	22	MYEF2, SOX9, PRL, TP53, DIRAS3, CFLAR, CDKN2A, STAT6, HSPA5, APP, CITED2, IGFBP1, CDKN1A, CLGN, TNFRSF10B, RELA, HPGD, NFKB1, MEF2A, IL18, MMP13, ESR1	2	ESR1, TP53
STAT3	NO	129	IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP12	4	PHB, TP53, AKT1, CDH1
USF2	NO	42	PF4, FCER1A, CTSB, IGF2R, NR5A1, CEACAM1, MYH9, TRAP, ASPH, CEACAM5, TOP3A, PTGS2, PDX1, CYP19A1, HOXB4, THBS1, CFTR, TCN2, TGFB1, PKLR, FMR1, SLC19A1, APC, CD2, TGFB2, PIGR, CTSD, ASCL2, PTPN6, CXCR4, BRCA1, FBP1, BRCA2, CXCR2, ATP5A1, APOA2, APOA5, B2M, HMOX1, TERT, ABCA1, LIPC	2	BRCA1, BRCA2
IFI16	NO	6	WT1, AR, TP53, MYC, ICAM1, BRCA1	2	BRCA1, TP53
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	4	TP53, BRCA2, AKT1, CDH1
RBL2	NO	3	BRCA1, RAD51, E2F4	2	BRCA1, RAD51
HMGA1	NO	17	PTGS2, SP1, CXCL1, XPA, POU1F1, INSR, CRYAB, CDC25A, TWIST1, IL1B, CDH1, CD44, TP53, RAG2, SLC2A3, BRCA1, KL	3	BRCA1, TP53, CDH1
EP300	NO	56	ALOX15, PCNA, MDM2, VCAM1, EIF2AK1, PTGS2, BIRC5, IFNG, EPO, PARP1, TBXAS1, BGLAP, CDKN2B, IL12B, RS1, LDHA, CCNE1, ABCB1, TP73, KLF5, LAMA3, HINFP, THBD, ERBB2, DNMT1, BRCA1, WT1, CCNB2, CDKN1A, ZEB1, GFAP, TRIM22, SPP1, CYBB, RELA, NPAS2, CXCL8, VEGFA, NFKB1, CRABP1, CA9, NR0B2, NR1H4, CREBBP, CLOCK, IGFBP3, IL5, IL6, SLC9A2, MMP9, IGF1, KRT16, MYC, CCND1, PML, RAD51	2	BRCA1, RAD51
RELA	NO	302	NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC6	4	TP53, BRCA2, AKT1, CDH1
EZH2	NO	31	PCNA, SFRP1, ADRB2, TWIST1, SNAI2, CDKN2B, CDKN2A, APC, RUNX3, PIP5K1C, CCNE1, DACT3, HOXB13, ALDH1A1, BRCA1, FOXC1, CDKN1A, VDR, HDAC1, RPLP0, CDH1, SATB1, TP53, AXL, ADAMTS1, SSTR1, FBXO32, MMP2, PEBP1, CIITA, CCND1	3	BRCA1, TP53, CDH1
TWIST1	NO	35	ATM, AKR1C2, CDH2, GDF15, MAPK1, FN1, RBL2, NR2F1, MYB, MMP2, RAP1A, BMI1, FOS, FGF2, RUNX2, ITGB1, CD44, ERBB3, PFDN4, DKK1, AKT2, ESR1, F2R, CDH1, NF1, TIMP1, ICAM1, BCL2, ILK, MAPK3, MMP1, YBX1, CTPS1, SRPX, DNM3	3	ATM, ESR1, CDH1
TWIST2	NO	25	ATM, AKR1C2, GDF15, POSTN, FN1, RBL2, NR2F1, MYB, RAP1A, FOS, RUNX2, ITGB1, CD44, ERBB3, DKK1, F2R, CDH1, NF1, CDH2, ICAM1, ILK, PFDN4, MMP2, CTPS1, SRPX	2	ATM, CDH1
RB1	NO	29	CDK1, DDIT3, BIRC5, MAP3K5, EBNA1BP2, DNMT3A, FOS, SFTPD, SP1, DHFR, HBP1, BRCA1, CDKN1A, RBL1, TFDP1, CDH1, ATF2, PCNA, E2F2, ELF1, E2F1, WRN, FGFR1, TP53BP2, RB1, IGF1, MYC, PPARG, E2F3	2	BRCA1, CDH1
ETS1	NO	90	PF4, ITGB3, TP53, TBXAS1, GABRE, PTHLH, TNFSF14, CD14, IGFBP1, BAX, SLC26A3, IL2, MGAT5, VWF, HPGD, CA9, MMP3, MMP9, CSF3R, IL2RB, TERT, THY1, FLT1, FGFBP1, CSF2, MYB, FLI1, ANGPT2, GP6, EGR1, TMEM158, CSNK2B, ERG, SQSTM1, WAS, F13A1, CD8A, MMP1, TGFBR2, ABCB1, ATXN2, NDRG1, SPRY2, HSPB8, BMP4, PRL, TBXA2R, CDKN2A, CHUK, NKX3-1, TAF12, MUC4, HSPE1, TRB, AXIN1, BRCA1, LCK, MMP10, SPP1, RHOC, ICAM1, ANPEP, CSNK2A1, IL5, CR1, HSPA6, HMOX1, CASP1, MDM2, PLAU, SNAI1, TFAP2A, CTSB, TRA, CXCR4, ECE1, SRD5A1, HSPA1L, DUSP6, CDKN1A, FOXD1, GRPR, CTGF, PARP1, TNC, HSPA8, IL3, COL1A1, MMP13, CD6	2	BRCA1, TP53
MTA1	NO	20	EPHA2, NOS2, MMP9, EGFR, MNAT1, MTA3, SNAI1, SMAD7, BCL2L1, CDH1, MYC, CDKN1A, SNAI2, PTEN, ITGB3BP, ESR1, CDKN2A, SUMO2, BRCA1, TFF1	3	BRCA1, ESR1, CDH1
NR3C1	NO	36	CALD1, PNRC1, TP53, RPS6KA3, BAX, SRF, SLC10A2, SCNN1A, BGLAP, TAT, RLN2, S100P, CYP19A1, MUC4, CCND1, NR1I2, ETS1, PPIG, BRCA1, ELK1, CSF1R, CDKN1A, UGT1A1, RLN1, SPP1, BAD, NFKB1, STAT1, COX1, NR3C1, CDK4, CDK6, CCND3, ATP1B1, ATF2, MAOA	2	BRCA1, TP53
AR	NO	83	UGT2B15, PTPN1, CDH11, AKR1C3, USP26, FOLH1, CCR2, CDK20, CDK6, PNRC1, ARG1, XIAP, VIM, ARG2, EGFR, CFLAR, ETV1, BSG, IGF1R, MUC1, WEE1, PTGS2, NKX3-1, AKT1, NRAS, CDH1, EP300, KLF5, ACTA1, CLK3, FN1, TNF, PRL, ERBB2, ERBB3, CRISP3, CTNNB1, PTEN, CRISP1, SERPINB5, TSC2, NAT1, CDKN1A, GREB1, SEPT7, IFI16, PIGR, KLK3, PC, STIM1, SRD5A3, TCF7L2, JUN, TMPRSS2, RELA, TJP1, BTG1, VEGFA, NFKB1, HMMR, FKBP5, KLK4, CRH, CDH2, BTG2, TGFA, SESN1, CDC6, TH, ALDH1A3, KISS1, KISS1R, PEBP1, KLK2, ATAD2, HMOX1, TSC1, WNT7B, PEG10, TRPS1, CCND1, PIP, FOXA1	3	CDH1, AKT1, HMMR
E2F4	NO	20	AURKB, MYC, TOPBP1, KIAA0101, CDK2, TTK, FGF2, LIN54, BIRC5, HCFC1, MAP3K5, MCM10, PLK1, CCNB1, PEG10, DIRAS3, BRCA1, CCND1, RAD51, E2F2	2	BRCA1, RAD51
E2F1	NO	123	WWOX, DOK1, MEFV, MYBL2, MCM8, FZD1, DIRAS3, PIN1, PCNA, DHFR, ETV4, LRBA, RPA2, FSHR, SERPINB5, PCSK6, TP53, FOXM1, E2F1, IL23A, CD2AP, HMGA1, XRCC1, FHIT, IRF3, ATM, MYC, MT1G, NRIP1, FLT1, RRP1B, MYB, SERPINE1, BMI1, CDKN2A, SKP2, MAPK8, CCNE1, CASP7, CDCA7, HIC1, THBS1, RB1, TNF, IL1B, ULK1, ERCC1, CUX1, TERT, MCL1, AR, KIR3DL1, NPAT, PDK4, DDB2, E2F6, ABCB1, BBC3, AURKA, NOX4, MYCN, CCNB1, TP73, FGFR1, RRM1, RRM2, HSPA5, TLR3, MUC4, CCND1, MCPH1, BRCA1, DRAM1, ERCC5, BIRC5, TYMS, RASGEF1B, MAP1LC3A, VEGFA, RACGAP1, FANCA, UHRF1, CHEK1, MCM5, RASGRP1, APAF1, ISYNA1, ECT2, TNFSF11, AURKB, CDK1, MDM2, DDIT3, MAP3K5, DBF4, PNRC2, KIF2C, POLA1, CTNNBIP1, ELF4, KDR, TP53INP1, ATAD2, CCL3, TK1, ATG5, CDKN1A, SIVA1, PEG10, TOP2A, CDAN1, CHEK2, DUSP1, ASF1B, DAPK2, PTPRO, BCL2, CREBBP, TP53BP2, GINS3, MYH10, PPARG, PPP1R13B	4	ATM, BRCA1, CHEK2, TP53

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
TSG101	YES	2	MAZ, TTF2	0
HMMR	YES	1	AR	0
ATM	YES	6	SP1, TWIST2, BTF3, TWIST1, BRCA1, E2F1	1	BRCA1
NQO2	YES	2	SP1, JUND	0
AKT1	YES	7	APC, STAT3, GLI1, AR, TP53, RELA, NFKB1	1	TP53
PPM1D	YES	1	CREB1	0
NBN	YES	2	MYC, SIRT1	0
CDH1	YES	49	AR, MTA2, FOXM1, ZEB2, SNAI1, TWIST2, TWIST1, EZH2, RBBP7, FOXA2, TCF3, LMO2, SPDEF, YBX1, KLF4, MTA1, LCOR, HDAC3, DNMT1, FOXQ1, HOXA7, TCF12, ESR1, SIRT1, WT1, ZEB1, FOSB, SMARCA4, VDR, HDAC1, TFAP2A, RELA, PARP1, HMGA2, NFKB1, KLF8, HDGF, STAT3, GATA3, HDAC2, SNAI2, CBX7, SALL4, RB1, HMGA1, KLF6, ZNF217, SIX1, HIF1A	1	ESR1
CHEK2	YES	2	E2F1, TP53	1	TP53
BRCA1	YES	33	WWP1, RBL2, EZH2, DLX4, CTBP1, SP1, E2F4, ID4, NCOA3, USF2, MTA1, E2F1, FOSL2, RBL1, FOXP3, IFI16, NFE2L2, SP100, TP53, CTCF, EP300, ETS1, E2F6, NR3C1, YY1, JUN, TP53BP1, RB1, HMGA1, ESR1, AHR, CREBBP, FOXA1	2	ESR1, TP53
BRCA2	YES	11	ESR2, CTBP1, HDAC1, ELF1, TP53, USF2, RELA, PARP1, BRCA1, NFKB1, USF1	2	BRCA1, TP53
BARD1	YES	1	BRIP1	1	BRIP1
KRAS	YES	1	MYC	0
TP53	YES	50	ATM, RELA, ERCC2, ETS2, ELF4, EZH2, HDAC9, FOS, PAX5, MCM4, RUVBL1, ZBTB2, EGR1, KLF4, MCM2, AATF, PAX2, TFDP1, STAT1, IRF1, PAX8, HIPK2, HDAC1, SIRT1, MDM4, VHL, ESR1, ING1, IFI16, STAT3, JUN, TP53, ABL1, NUPR1, NFKB1, E2F1, ETS1, CREBBP, HOXA10, NR3C1, YY1, NF1, ING4, HMGA1, SOX6, BDP1, MYC, PPARG, PML, MYCN	3	ATM, ESR1, TP53
ESR1	YES	27	MECP2, RUNX2, TWIST1, TFAP2C, PGR, HDAC9, NCOR1, SP1, NKX3-1, ARNT, ID4, HDAC7, MTA1, BRCA1, BARX2, XBP1, STAT5A, LEF1, KDM4B, HDAC1, BARD1, STAT5B, PIAS3, TP53, GATA3, NR2E3, ESR1	4	BRCA1, BARD1, TP53, ESR1
PHB	YES	4	VDR, HDAC1, HDAC2, STAT3	0
CASP8	YES	4	RUNX3, MEN1, DNMT1, CREB1	0
RAD51	YES	4	CREBBP, EP300, RBL2, E2F4	0
PIK3CA	YES	1	FOXO3	0
PMAIP1	NO	7	ATM, ESR1, KLF9, TP53, KLF6, TP73, MYC	3	ATM, ESR1, TP53
GADD45A	NO	7	ATM, NFYA, POU2F1, TP53, BRCA1, JUND, POU5F1	3	ATM, BRCA1, TP53
IGF1R	NO	8	WT1, ATM, VHL, TBP, AR, TP53, BRCA1, NKX3-1	3	ATM, BRCA1, TP53
XPC	NO	6	SP1, TP63, CREB1, TP53, BRCA1, HIF1A	2	BRCA1, TP53
CTSD	NO	9	ARNT, ESR2, TP53, USF2, USF1, ESR1, NFATC3, BRCA1, MYCN	3	BRCA1, ESR1, TP53
MDM2	NO	23	TFAP4, TP53, NFATC2, JUND, DNMT3A, SP1, ELF4, ZBTB2, SKI, MLLT10, E2F1, FOSL2, ELL, MLLT3, ETS2, EP300, ETS1, FUS, TSG101, ESR1, NR4A1, TP73, MYCN	3	ESR1, TP53, TSG101
TERT	NO	30	CTCF, MZF1, ETS2, MXD1, USF2, SP1, ID2, TAL1, SMAD3, DNMT1, E2F1, WT1, ESR2, HDAC1, JUN, TP53, RELA, NFKB1, TP73, ETS1, HIF1A, STAT3, MEN1, NFATC2, FLI1, USF1, ESR1, MYC, PITX1, MYCN	2	ESR1, TP53
HIPK2	NO	3	ATM, PML, TP53	2	ATM, TP53
CCND1	NO	62	POU4F2, RELA, E2F4, MYBL2, AR, MECP2, PML, BHLHE41, EZH2, ATF2, PGR, JUND, FOS, PAX5, STAT5B, RUNX3, RNF14, POU2F1, EGR1, EP300, KLF4, HOXA1, STAT5A, CTNNB1, BRCA1, ESR1, SIRT1, VHL, SP1, KLF6, LEF1, HDAC1, KDM4B, NKX3-1, SOX2, HOXB7, JUN, ZNF24, TP53, NANOG, E2F8, NELFCD, NFKB1, E2F1, FHL2, STAT3, TCF4, BTG2, NR3C1, SP4, TSC22D3, SNIP1, HEXIM1, ING4, LIN28A, HIF1A, SMARCA4, SP3, MYC, PPARG, KLF5, SOX6	3	BRCA1, ESR1, TP53
SLC2A1	NO	4	ATM, HDAC5, HIF1A, TP53	2	ATM, TP53
CDKN1B	NO	27	KAT2B, NFYA, TP53, SP1, KLF4, HDAC3, COPS5, FOXO1, BRCA1, VHL, CUX1, ZNF300, VDR, HDAC1, STAT3, NFYC, HOXB7, NR4A1, UTF1, ING4, FHL2, NFYB, PROX1, MEN1, ESR1, IRF9, MYCN	3	BRCA1, ESR1, TP53
CDKN1A	NO	118	ABL1, TFAP4, TP53, MYF5, TCF3, HDAC9, PAX5, ZBTB2, LCOR, E2F3, ZBTB5, HSF1, ELL, TSC22D3, NCOA1, TAF1, RELA, MYOD1, STAT1, PTTG1, KLF16, ESR1, JUNB, MYCN, KAT2B, AR, BCL6, KLF10, EZH2, ARID1A, JUND, SP1, CEBPB, ZFHX3, ZNF300, EGR1, KLF4, AATF, HDAC7, HBP1, SMARCA4, ESR2, FOXP3, RARA, NELFCD, ING4, HDAC4, TBX2, IRF1, HDAC2, ETV6, SIRT2, MYOG, KLF6, TP73, SOX6, ATM, ERCC2, SMAD4, ETS2, NUPR1, PTMA, MLLT10, SMAD3, ETS1, CBX8, BRCA1, HIPK2, SIRT1, WT1, ZNF76, HDAC1, SMAD2, MLLT3, TFAP2A, EP300, FHL2, TP63, IRF9, EHMT2, TFAP2C, NFIX, RUNX3, RB1, HNF4A, NFIB, TAF5, SOX9, TBP, EAPP, ZBTB17, TAF4, REL, RELB, PML, SMAD7, NPM1, POU5F1, E2F1, TBX3, FOXG1, MYF6, NFIA, ATF2, PARP1, NFKB1, STAT3, GFI1, NR3C1, CREBBP, MTA1, JUN, KLF2, CDX2, SP3, MYC, PPARG, ING1	4	ATM, BRCA1, ESR1, TP53
EGR1	NO	17	SP1, ETS2, RELA, ATF5, MAML1, HDAC1, NFKB1, TP53, NAB2, NKX2-3, RBMX, FOXO1, BRCA1, ETS1, STAT6, KLF5, STAT1	2	BRCA1, TP53
CTNNB1	NO	8	AR, NKX2-5, LEF1, TP53, NELFCD, SOX6, ESR1, SIRT1	2	ESR1, TP53
FOS	NO	31	HMGN1, MITF, NCOA6, TBP, SRF, RBMX, FOS, ZBTB7A, SP1, NKX3-1, ARNT, STAT6, CREB1, BRCA1, HOPX, ELK1, TWIST2, ESR1, ESR2, ELK4, HDAC1, NF1, TWIST1, HSF2, GTF2I, STAT3, CREM, JUN, RB1, SMARCA4, AHR	2	BRCA1, ESR1
VEGFA	NO	53	ATM, WT1, AR, FOXM1, ID3, ATF4, COPS5, TFAP2A, EPAS1, PGR, RUNX1, SP1, NKX3-1, TEAD4, ARNT, EGR1, EP300, KLF5, MYC, SMAD3, HDGF, HTATIP2, DNMT1, FOXO3, HIPK2, ZFP36, HEXIM1, VHL, ZFP36L1, XBP1, ESR2, NR1H4, HOXB7, JUN, ZNF24, TP53, RELA, HDAC4, RUNX2, NFKB1, BRCA1, FOXQ1, E2F1, STAT3, UHRF1, TCF4, PTTG1, ZNRD1, HIF1A, ESR1, SP3, MEF2C, E2F3	4	ATM, BRCA1, ESR1, TP53
BTG2	NO	7	AR, RELA, FOXM1, TP53, ESR1, NFKB1, PHB2	2	ESR1, TP53
CYP19A1	NO	23	NR5A1, NR0B1, FOXL2, NR2F1, CREB1, PGR, RARG, SP1, USF2, NR5A2, BRCA1, ESRRA, WT1, JUN, RELA, NFKB1, STAT3, NR3C1, NR2F6, CEBPB, CEBPD, ESR1, USF1	2	BRCA1, ESR1
TNFRSF10B	NO	16	SP1, ATM, STAT3, ELK1, GLI1, YY1, DDIT3, TP53, MYC, DNMT1, GLI2, RELA, HDAC9, NFKB1, ATF4, SIRT1	2	ATM, TP53
FOXM1	NO	7	SP1, ATM, FLI1, MYC, TP53, E2F1, FOXO3	2	ATM, TP53
FLT1	NO	8	EGR1, ATF1, CREB1, TP53, ESR1, EPAS1, E2F1, ETS1	2	ESR1, TP53
STAT3	NO	9	SOX3, FOXO1, HDAC1, TP53, TCF7L2, PIAS3, ZNF382, BRCA1, STAT1	2	BRCA1, TP53
HR	NO	2	RAD51, TP53	2	RAD51, TP53
DDB2	NO	7	SP1, TP63, TP53, NF1, BRCA1, E2F1, E2F3	2	BRCA1, TP53
DUSP1	NO	7	ATM, CREM, TP53, ATF2, PGR, E2F1, STAT6	2	ATM, TP53
MYC	NO	66	E2F4, LEF1, PGR, FOXM1, TBP, FUBP1, TP53, MYBL2, SMAD4, MXI1, MYB, AATF, ZNF382, FOS, ZBTB7A, SP1, E2F5, RBL1, TCF4, TBL1X, EP300, SMAD7, HDAC3, TCF3, SRSF1, SMAD3, CNBP, TLX1, ESR1, SIRT1, WT1, APC, CTNNB1, CEBPE, PRDM1, IFI16, DLX5, HDAC10, ZNF300, JUN, ETS2, RELA, BCL6, NFKB1, BRCA1, E2F1, STAT3, HDAC11, CEBPA, HOXA1, PTTG1, PPARG, YY1, MTA1, HDAC2, NF1, SNIP1, RUNX3, RB1, CTCF, ENO1, BDP1, AHR, STAT4, RFX1, HNF4A	3	BRCA1, ESR1, TP53
CYP1A1	NO	12	RELA, ARNT, VDR, NFKB1, KLF4, NFIC, RARA, ESR1, BRCA1, PPARA, AHR, USF1	2	BRCA1, ESR1
CDK4	NO	12	SP1, STAT3, SOX9, NR3C1, IRF1, RELA, TP53, SATB1, ESR1, MYC, NFKB1, SOX6	2	ESR1, TP53
EGFR	NO	30	AR, BCL3, WWP1, NR3C2, TFAP2A, PGR, NFKB2, SP1, EGR1, PML, HDAC3, MTA1, BRCA1, WT1, VDR, HOXB7, JUN, TP53, RELA, LRRFIP1, NFKB1, STAT1, STAT3, YY1, YBX1, ESR1, JUNB, PPARG, CREBBP, TSG101	4	BRCA1, ESR1, TP53, TSG101
TFF1	NO	17	HMGN1, NFATC3, ESR2, AIP, HDAC1, RELA, MTA1, MECP2, NELFB, JUN, FOXA2, ESR1, SP3, BRCA1, NFKB1, NCOA4, FOXA1	2	BRCA1, ESR1
BAX	NO	25	ATM, ING4, ERCC2, TP53, MYCN, PAX5, SP1, GFI1, PML, ABL1, AATF, MLLT10, ETS1, WWTR1, ELL, MLLT3, PER1, RELA, NFKB1, STAT1, TP63, NR3C1, ING1, TP73, HIF1A	2	ATM, TP53
MCL1	NO	12	ATM, STAT3, ELK1, RELA, ATF4, DDIT3, TP53, SRF, ELK4, E2F1, NFKB1, SIRT1	2	ATM, TP53
CCNA2	NO	14	SP1, CREM, RBL1, TP53, E4F1, SOX6, NFATC2, NR4A1, E2F3, ESR1, MYC, BCL6, ZBTB16, ZHX2	2	ESR1, TP53
FAS	NO	25	ATM, NFYA, TP53, ATF2, PURA, FOS, SP1, EGR1, GLI2, STAT1, GLI1, YBX1, HDAC1, NFYB, NFYC, JUN, TFAP2A, RELA, NFKB1, HDGF, STAT3, SREBF1, SREBF2, NFKBIA, YY1	2	ATM, TP53
RB1	NO	19	KAT2B, MYC, UHRF1, BDP1, RB1CC1, YY1, MYF6, RB1, HCFC1, MYOG, ID2, DNMT1, TP53, CTNNB1, MYOD1, DNMT3A, MYF5, E2F1, PAX5	2	RB1CC1, TP53
CCNB1	NO	15	MYC, FOXM1, E2F4, PTTG1, IRF1, KLF5, TP53, TFAP2A, RELA, KLF4, YBX1, BRCA1, NFKB1, E2F1, USF1	2	BRCA1, TP53
E2F1	NO	27	KAT2B, EIF2AK2, E2F7, POLR1A, PGR, SP1, NFKB1, YBX1, PAX8, NR2F2, E2F8, SIN3A, TRIM16, NR4A1, TP53, RELA, PARP1, PA2G4, E2F1, E2F6, NR0B2, IRF1, HES1, HCFC1, RB1, ESR1, TP73	2	ESR1, TP53
TYMS	NO	8	SP1, TFDP1, TP53, TFCP2, YBX1, ESR1, E2F1, USF1	2	ESR1, TP53
BCL2	NO	43	ATM, ING4, ERCC2, TBP, TP53, TWIST1, CREB1, MYB, SIM2, PGR, PAX5, SP1, CEBPA, ATF5, MSX2, NCOA3, GLI2, NR1I2, HOXA1, GLI1, TFAP2A, E2F1, DEK, WT1, ATF1, ING2, SATB1, PER1, ABL1, PARP1, NFKB1, MYC, DDB2, STAT3, BACH2, ZBTB16, RELA, ZNRD1, ESR1, PAWR, PPARG, IRF1, FOXA1	3	ATM, ESR1, TP53

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
TSG101	HMMR	No	1	THRSP
TSG101	ATM	No	8	DAXX, BCAS3, MDM2, BAG6, TP53, MTA3, HNRNPUL1, TFF1
TSG101	NQO2	No	2	NXF1, MOV10
TSG101	AKT1	No	15	NF2, IQGAP1, MDM2, VCP, DNAJB1, CDKN1A, FASN, RASL10B, NEDD4, AR, YBX1, THRSP, EP300, MTA3, TFF1
TSG101	XRCC3	No	7	SCGB3A1, BCAS3, XPO1, SCAMP3, TNKS1BP1, TRIM25, TFF1
TSG101	RB1CC1	No	4	UBC, THRSP, RNF111, TP53
TSG101	PPM1D	No	2	UBC, MDM2
TSG101	RAD54L	No	1	BAG6
TSG101	FAM175A	No	1	UBC
TSG101	NBN	No	3	EP300, RAD18, MDM2
TSG101	CDH1	No	5	NDRG1, ACTN4, IQGAP1, EP300, MDM2
TSG101	CHEK2	No	5	TP53, DAPK3, MDM2, AATF, VCP
TSG101	BRCA1	No	13	AR, VCP, PABPC1, RAD18, DNAJB1, TP53, TRIM74, JUN, TRIM46, UBC, YBX1, UBE2I, EP300
TSG101	BRCA2	No	3	VPS28, NEDD4, TP53
TSG101	BARD1	No	10	LARP1, SMCHD1, WDR5, WDR26, TP53, EWSR1, YBX1, FAM9B, HNRNPUL1, MOV10
TSG101	KRAS	No	2	THRSP, BCAS3
TSG101	TP53	Yes	25	VASP, PABPC1, DAXX, DAPK3, EWSR1, BCR, IQGAP1, VCP, THRB, DNAJB1, CEP55, CDKN1A, MDM2, TP53, EP300, MOV10, CHMP4B, NR3C1, WDR5, STK11, YBX1, UBC, UBE2I, PDLIM7, TSG101
TSG101	ESR1	No	21	ARFGAP2, CDKN1A, BCAS3, VCP, PABPC1, KLK5, EP300, CAPRIN1, WDR5, UPF1, SFPQ, TP53, JUN, MDM2, XPO1, NONO, EWSR1, YBX1, UBE2I, ACTN4, TRIM25
TSG101	PHB	No	9	NF2, AR, BCAS3, VCP, ADRB2, TP53, UBC, XPO1, NTRK1
TSG101	PALB2	No	4	THRSP, BCAS3, MOV10, KLK6
TSG101	CASP8	No	6	KLK5, BIRC2, YBX1, PRSS50, TP53, UBC
TSG101	RAD51	No	5	UBE2I, TFF1, RAD18, NXF1, TP53
TSG101	PIK3CA	No	4	NTRK1, THRSP, WDR5, GRB2
HMMR	ATM	No	3	BRCA1, IL24, NAT2
HMMR	AKT1	No	8	IL24, CALM1, LRRK2, TBK1, DCTN1, ACTB, BRCA1, THRSP
HMMR	BRIP1	No	1	BRCA1
HMMR	XRCC3	No	2	ITIH5, GREB1
HMMR	RB1CC1	No	5	THRSP, ITIH5, TBK1, IL24, GREB1
HMMR	PPM1D	No	2	ITIH5, NAT2
HMMR	FAM175A	No	1	BRCA1
HMMR	NBN	No	3	BRCA1, BACH1, NAT2
HMMR	CHEK2	No	5	BRCA1, IL24, MAPK1, ITIH5, CDH13
HMMR	BRCA1	Yes	6	BACH1, MAPK1, ITIH5, AURKA, TPX2, BRCA1
HMMR	BRCA2	No	2	BRCA1, BACH1
HMMR	BARD1	No	4	AURKA, BRCA1, MAPK1, BACH1
HMMR	KRAS	No	4	CALM1, IL24, MAPK1, THRSP
HMMR	TP53	No	11	SPICE1, CSNK1E, BACH1, AURKA, NIN, MAPK1, TUBB2A, CSNK1A1, ACTB, BRCA1, STX5
HMMR	ESR1	No	6	CALM1, TBK1, MAPK1, SVIL, ACTB, BRCA1
HMMR	PHB	No	2	ACTB, TMEM63B
HMMR	PALB2	No	6	IL24, GREB1, BACH1, NAT2, THRSP, BRCA1
HMMR	CASP8	No	5	IL24, LRRK2, MAPK1, GREB1, CDH13
HMMR	RAD51	No	5	ITIH5, BRCA1, IL24, CDH13, NAT2
HMMR	PIK3CA	No	2	IL24, THRSP
ATM	AKT1	No	25	MDM2, MAPK14, IKBKG, MTA3, SKP2, FOXO3, SMAD7, CREB1, WHSC1L1, PPP1CC, TOPBP1, SMARCB1, PRKDC, TRAF6, OSGIN1, NR4A1, TCL1A, BRCA1, TFF1, IL24, HSPA8, PPP1CA, PPP2R4, EIF4EBP1, BCL10
ATM	BRIP1	No	5	BRCA1, TOPBP1, BLM, RPA1, MLH1
ATM	XRCC3	No	7	BRCA2, CDK9, OSGIN1, TFF1, BCAS3, RNF20, RAD51
ATM	RB1CC1	No	11	VHL, IL24, RNF20, ERRFI1, HUWE1, RPA1, TP53, RPA2, DYRK2, SMARCB1, WHSC1L1
ATM	PPM1D	No	6	MDM2, ERRFI1, OSGIN1, NAT2, H2AFX, WHSC1L1
ATM	RAD54L	No	1	BAG6
ATM	FAM175A	No	3	PARP1, BRCA1, MDC1
ATM	NBN	Yes	33	ATM, ATRIP, MDM2, FANCD2, KAT5, MDC1, RAD50, RFC1, BMI1, MSH6, SKP2, DCLRE1C, ATR, MSH2, RPA1, MCPH1, RBBP8, RPA2, SNW1, BRCA1, DDX1, TOPBP1, TERF1, MRE11A, PRKDC, TERF2, ATF2, NAT2, H2AFX, WRN, BLM, MLH1, XRCC5
ATM	CDH1	No	10	HSPA8, XRCC5, MDM2, HDAC1, SMAD7, PPP1CA, SKP2, E2F1, RAD17, GMNN
ATM	CHEK2	Yes	20	ATM, VHL, ATR, BRCA2, MDM2, MSH2, PRKDC, IL24, ELAVL1, TP53BP1, TP53, MDC1, RAD50, TRIM28, PER3, NR4A1, BRCA1, RNF20, CHEK2, WHSC1L1
ATM	BRCA1	Yes	49	ATM, ATRIP, RELA, CHEK1, FANCD2, SMARCB1, TOPBP1, SMC3, CSNK1D, RAD51, RFC1, PEX5, KAT5, H2AFX, SKP2, DCLRE1C, ATR, MLH1, BRAT1, POLR2A, RPA1, CDK9, RBBP8, FOXO3, MRE11A, NBN, SMC1A, TERF1, HDAC1, PRKDC, TERF2, TP53, MDC1, ABL1, PARP1, HSPA8, MSH6, BRCA1, E2F1, BRCA2, HUWE1, TP53BP1, PPP1CA, BLM, HIF1A, RAD50, CHEK2, MSH2, XRCC5
ATM	BRCA2	Yes	11	ATM, ATR, TP53, SMC3, MCPH1, RPA1, CHEK2, BRCA1, H2AFX, RAD51, FANCD2
ATM	BARD1	No	26	MDC1, TOPBP1, HNRNPUL1, RAD50, KAT5, MSH6, SKP2, MSH2, CDK9, RBBP8, BRCA1, TOP1, NBN, SMC1A, MRE11A, ELAVL1, TP53, RELA, PARP1, H2AFX, BRCA2, AP1B1, POLR2A, RAD51, MLH1, XRCC5
ATM	KRAS	No	5	TRAF6, OSGIN1, BCAS3, IL24, ELAVL1
ATM	TP53	Yes	58	ATM, WWOX, RELA, MDM2, H2AFX, CHEK1, TP53, KAT5, DAXX, MDC1, RFC1, CSNK1D, CREB1, RPA1, BMI1, RNF20, MSH6, ATR, FOXO3, MSH2, BRCA1, SMAD7, SIRT7, SOCS1, E4F1, RPA2, SNW1, MAPK14, VPRBP, SMARCB1, TOP1, VHL, SPSB1, PPP1CA, HDAC1, PRKDC, CDKN2C, ELAVL1, MED1, NR4A1, TRIM28, ABL1, PARP1, HSPA8, XPC, BANP, CHEK2, PPP1CC, BRCA2, WRN, HUWE1, TP53BP1, KAT8, BLM, RAD51, RRM2B, HIF1A, TAF1
ATM	ESR1	No	32	MDM2, TOPBP1, SMC3, RAD50, PPP1CA, KAT5, SKP2, MSH2, RAD51, BRCA1, DDX1, HDAC1, TOP1, SMC1A, BCAS3, CHD4, PRKDC, TRAF6, MED1, TP53, RELA, PARP1, H2AFX, PPP1CC, WHSC1L1, E2F1, HSPA8, RNF40, SPOP, POLR2A, HIF1A, XRCC5
ATM	PHB	No	8	BCAS3, HDAC1, HUWE1, TP53, ATF2, PARP1, E2F1, SKP2
ATM	PALB2	No	9	IL24, BRCA2, ERRFI1, ALB, RBBP8, NAT2, BCAS3, BRCA1, RAD51
ATM	CASP8	No	8	IL24, ERRFI1, TRAF6, BLM, TP53, PARP1, GMNN, WHSC1L1
ATM	RAD51	Yes	20	ATM, IL24, BRCA2, ABL1, WRN, H2AFX, MSH2, RPA1, CHEK1, BLM, TP53, MDC1, MCPH1, WHSC1L1, TFF1, NAT2, MSH6, BRCA1, RAD51, FANCD2
ATM	PIK3CA	No	3	HDAC1, ATR, IL24
NQO2	BARD1	No	1	MOV10
NQO2	TP53	No	2	COPS5, MOV10
NQO2	ESR1	No	1	COPS5
NQO2	PALB2	No	1	MOV10
NQO2	RAD51	No	1	NXF1
AKT1	BRIP1	No	2	BRCA1, TOPBP1
AKT1	XRCC3	No	11	FKBP5, IMPDH2, SNAI1, MRC2, SERPINB5, OSGIN1, PHB2, HSP90AB1, NCOA4, APP, TFF1
AKT1	RB1CC1	No	12	IL13RA2, IL24, PINK1, SMARCB1, MAP3K5, SKI, EPSTI1, WHSC1L1, CTNNB1, THRSP, TBK1, MRC2
AKT1	PPM1D	No	5	MRC2, EPSTI1, OSGIN1, MDM2, WHSC1L1
AKT1	FAM175A	No	2	BRCA1, HSPA4
AKT1	NBN	No	14	TOPBP1, MDM2, CASC3, HSPA4, RICTOR, SNAI1, MTOR, TERF2IP, SIRT1, MAPKAP1, PRKDC, BRCA1, EP300, SKP2
AKT1	CDH1	No	17	HSPA9, HSPA8, CTNNB1, MDM2, ILK, EP300, CREBBP, SMAD7, IQGAP1, PPP1CA, PTEN, HSP90AA1, EGFR, SRC, HSPA5, GSK3B, SKP2
AKT1	CHEK2	No	14	KAT2B, IL24, WHSC1L1, MDM2, VCP, PRKDC, PPP2CA, ENO1, NR4A1, APP, ST14, PPP2R1A, BRCA1, SIRT1
AKT1	BRCA1	Yes	42	AR, PIAS1, VCP, PPP2CA, EZH2, PPP1CA, CTBP1, SKP2, COMMD1, YBX1, ITPR1, SMARCC2, NPM1, DNAJB1, SMAD3, CTNNB1, DNMT1, FOXO3, YWHAZ, TOPBP1, ESR1, SMARCB1, PRKDC, HSP90AA1, NFE2L2, PPP1CB, AKT1, EP300, BRCA1, SMARCC1, CREBBP, FANCA, HSPA8, RICTOR, XIAP, MTOR, TUBB, CLK2, ENO1, MAPKAP1, CSNK2A1, PHB2
AKT1	BRCA2	No	5	KAT2B, BRCA1, SMAD3, SMAD2, NEDD4
AKT1	BARD1	No	12	CCDC88A, TOPBP1, PIAS1, ZHX1, COMMD1, NPM1, SETDB1, YWHAZ, ESR1, YBX1, BRCA1, SKP2
AKT1	KRAS	No	10	IL24, CALM1, SERPINB5, PIK3CA, OSGIN1, TRAF6, RAF1, SORBS3, THRSP, APP
AKT1	TP53	No	74	KAT2B, BCL2L1, PIAS1, ZHX1, VCP, PSMC5, YWHAE, DDX5, SRC, CREB1, VIM, APOH, HSP90AB1, HSPA5, CTBP1, STUB1, IQGAP1, TNK2, MDM2, TUBB, MAPK8, YBX1, GSK3B, MDH1, BRCA1, SMAD7, STK4, SKI, DNAJB1, SMAD3, DAB2IP, TBC1D4, DNMT1, MAPK14, APPL1, ALYREF, YWHAZ, HSPA9, SFN, PIAS2, GAPDH, PRKDC, SMARCB1, MAPK9, CLTC, SMAD2, IKBKB, MUL1, NR4A1, HSP90AA1, PTEN, NPM1, PPP2R1A, PPP3CA, EP300, FOXO3, KAT6A, SMARCC1, CREBBP, PPP1CC, HSPA8, SNAI1, CSNK2A1, HSPA4, ACTB, MTOR, CDKN1A, PPP1CA, CHUK, HSPB1, SIRT1, ESR1, TPM4, UCHL1
AKT1	ESR1	Yes	71	DDX5, PIAS1, PTEN, VCP, PRKCZ, PSMC5, TOPBP1, ESR1, FHL1, SRC, EZH2, NSF, EGFR, GNB1, SERPINB5, SFN, PAK1, SKP2, HSP90AA1, CLTC, TSC2, TUBB, KAT6A, YBX1, PA2G4, PPP2CA, MAPKAPK2, SKI, NCOR2, HDAC3, MDM2, SMAD3, STUB1, FOXO1, FOXO4, BRCA1, ALYREF, SIRT1, EPSTI1, CDKN1A, CALM1, CTNNB1, PIAS2, GAPDH, KRT10, PRKDC, SMAD2, ACTB, TRAF6, AKT1, NPM1, PPP2R1A, NCOA4, EP300, PPP1CC, WHSC1L1, FKBP5, PPIA, HSPA8, TBK1, HSPA4, IRS1, PPP1CA, CHUK, HSPB1, TCOF1, TSC1, PIK3CA, EIF4A1, CREBBP, PHB2
AKT1	PHB	No	16	NF2, AR, HSP90AB1, VCP, CASC3, SKP2, YWHAE, CLTC, NPM1, ACTB, RAF1, YWHAZ, ESR1, ATP1A1, PHB2, ST14
AKT1	PALB2	No	8	IL13RA2, IL24, SNAI1, HIST2H2BE, SERPINB5, BRCA1, THRSP, MRC2
AKT1	CASP8	No	19	IL13RA2, S100A14, AGR3, IL24, WHSC1L1, PTEN, LRRK2, MAPK8, SERPINB5, XIAP, CHUK, IKBKB, TRAF6, EPSTI1, VIM, YBX1, ST14, CLIP3, CASC3
AKT1	RAD51	No	9	IL24, ST14, HSP90AA1, TERF2IP, VIM, TFF1, ESR1, BRCA1, WHSC1L1
AKT1	PIK3CA	Yes	12	IL13RA2, IL24, AKT1, NOTCH1, IRS1, DDX5, ERBB3, SMAD2, ESR1, SMAD3, THRSP, APPL1
BRIP1	XRCC3	No	2	PMS2, MMS19
BRIP1	RB1CC1	No	2	VAPB, RPA1
BRIP1	FAM175A	No	2	BRCA1, BARD1
BRIP1	NBN	No	6	TOPBP1, MLH1, BARD1, RPA1, BLM, BRCA1
BRIP1	CDH1	No	1	LMNA
BRIP1	CHEK2	No	1	BRCA1
BRIP1	BRCA1	Yes	9	HNRNPC, TOPBP1, MLH1, BARD1, PMS2, RPA1, BLM, USP37, BRCA1
BRIP1	BRCA2	No	6	HNRNPC, BARD1, PMS2, RPA1, PMS1, BRCA1
BRIP1	BARD1	Yes	5	BARD1, BRCA1, TOPBP1, HNRNPC, MLH1
BRIP1	KRAS	No	1	HNRNPC
BRIP1	TP53	No	5	BRCA1, RPA1, BARD1, BLM, LMNA
BRIP1	ESR1	No	5	BARD1, BRCA1, TOPBP1, HNRNPC, MMS19
BRIP1	PHB	No	1	LMNA
BRIP1	PALB2	No	2	BRCA1, HNRNPC
BRIP1	CASP8	No	1	BLM
BRIP1	RAD51	No	5	HNRNPC, BRCA1, BARD1, BLM, RPA1
XRCC3	RB1CC1	No	6	ITIH5, MRC2, GREB1, PSMC3IP, RNF20, BAP1
XRCC3	PPM1D	No	3	OSGIN1, ITIH5, MRC2
XRCC3	FAM175A	No	1	FANCG
XRCC3	NBN	No	2	SNAI1, BAP1
XRCC3	CDH1	No	1	HSPD1
XRCC3	CHEK2	No	7	UBR5, BRCA2, ITIH5, FAM84B, PSMC3IP, RNF20, APP
XRCC3	BRCA1	No	16	HNRNPA2B1, PMS2, BRCA2, COPE, SSX2IP, BAP1, GPN1, ZC3H11A, DNAJA1, EIF5B, RAD51, HSPD1, MED17, ITIH5, PHB2, CDK9
XRCC3	BRCA2	Yes	3	PMS2, RAD51, FANCG
XRCC3	BARD1	No	9	CCAR1, UBR5, MED17, SNRNP70, NSRP1, CDK9, BRCA2, RBM17, RAD51
XRCC3	KRAS	No	4	OSGIN1, BCAS3, SERPINB5, APP
XRCC3	TP53	No	21	CCAR1, UBR5, TCP1, BRCA2, HSP90B1, UBR4, SNAI1, CKAP4, SF3B2, ATP5A1, SSX2IP, HNRNPA2B1, CCT8, RAD51, DNAJA1, HSP90AB1, MED17, RNF20, EIF5B, CCT3, CCT6A
XRCC3	ESR1	No	25	MED24, XPO1, MED16, MED17, SF3B1, PSMC3IP, HSP90B1, RPL10, HNRNPA2B1, FARSA, UNC45A, BCAS3, BAP1, SERPINB5, TECR, HSPD1, NCOA4, MMS19, FKBP5, CXCL1, GCN1L1, NCAPD3, RAD51, TRIM25, PHB2
XRCC3	PHB	No	7	BCAS3, UQCRQ, TMPO, SSR3, XPO1, HSP90AB1, PHB2
XRCC3	PALB2	No	8	BRCA2, SERPINB5, SNAI1, FAM84B, MRC2, GREB1, BCAS3, RAD51
XRCC3	CASP8	No	4	PSMC3IP, BAP1, SERPINB5, GREB1
XRCC3	RAD51	Yes	9	BRCA2, TIMM13, ITIH5, FAM84B, HNRNPA2B1, RAD51, SWSAP1, RAD51C, TFF1
XRCC3	PIK3CA	No	1	PSMC3IP
RB1CC1	PPM1D	No	8	ERRFI1, GLCE, UBC, EPSTI1, MRC2, LYPD3, ITIH5, WHSC1L1
RB1CC1	RAD54L	No	1	SGTB
RB1CC1	FAM175A	No	1	UBC
RB1CC1	NBN	No	3	RPA1, BAP1, RPA2
RB1CC1	CDH1	No	1	CTNNB1
RB1CC1	CHEK2	No	8	VHL, IL24, ITIH5, TP53, LYPD3, PSMC3IP, RNF20, WHSC1L1
RB1CC1	BRCA1	No	9	PRKAA2, SMARCB1, HUWE1, RPA1, TP53, CTNNB1, UBC, ITIH5, BAP1
RB1CC1	BRCA2	No	2	TP53, RPA1
RB1CC1	BARD1	No	4	MOB4, TACC1, TP53, ERCC6L
RB1CC1	KRAS	No	3	IL24, THRSP, EEA1
RB1CC1	TP53	Yes	15	VHL, RPA2, PTK2, SAFB2, SMARCB1, RPA1, HUWE1, SAFB, CCDC8, TP53, RFWD2, SKI, UBC, TCEAL4, RNF20
RB1CC1	ESR1	No	14	HBP1, RBMX, TBK1, BAP1, SAFB2, GLCE, SAFB, SKI, SKIL, EPSTI1, TP53, CTNNB1, PSMC3IP, WHSC1L1
RB1CC1	PHB	No	4	UBC, HUWE1, TP53, CCDC8
RB1CC1	PALB2	No	7	IL13RA2, IL24, ERRFI1, GREB1, LYPD3, THRSP, MRC2
RB1CC1	CASP8	No	17	IL13RA2, EPSTI1, BLID, GREB1, ERRFI1, LYPD3, HBP1, TP53, UBC, GLCE, BAP1, UMPS, TRAF2, PSMC3IP, VPS45, IL24, WHSC1L1
RB1CC1	RAD51	No	7	IL24, ITIH5, RPA1, TP53, UMPS, SGOL1, WHSC1L1
RB1CC1	PIK3CA	No	5	IL13RA2, THRSP, PSMC3IP, IL24, UMPS
PPM1D	FAM175A	No	1	UBC
PPM1D	NBN	No	4	H2AFX, MDM2, CDC5L, NAT2
PPM1D	CDH1	No	1	MDM2
PPM1D	CHEK2	No	6	MDM2, ITIH5, DIRAS3, LYPD3, RHOBTB2, WHSC1L1
PPM1D	BRCA1	No	5	KDM1A, UBC, H2AFX, RAD21, ITIH5
PPM1D	BRCA2	No	2	H2AFX, RAD21
PPM1D	BARD1	No	1	H2AFX
PPM1D	KRAS	No	2	OSGIN1, DIRAS3
PPM1D	TP53	No	4	KDM1A, UBC, H2AFX, MDM2
PPM1D	ESR1	No	6	KDM1A, MDM2, EPSTI1, GLCE, H2AFX, WHSC1L1
PPM1D	PHB	No	1	UBC
PPM1D	PALB2	No	7	CASZ1, ERRFI1, DIRAS3, NAT2, LYPD3, RHOBTB2, MRC2
PPM1D	CASP8	No	6	ERRFI1, EPSTI1, UBC, GLCE, LYPD3, WHSC1L1
PPM1D	RAD51	No	4	H2AFX, ITIH5, WHSC1L1, NAT2
PPM1D	PIK3CA	No	1	BEX2
RAD54L	TP53	No	1	HECW2
FAM175A	NBN	No	6	BARD1, HSPA4, PAXIP1, MDC1, BRCA1, SUMO2
FAM175A	CHEK2	No	2	BRCA1, MDC1
FAM175A	BRCA1	Yes	10	BRE, BABAM1, BARD1, MDC1, UBC, UIMC1, PARP1, BRCA1, SUMO2, BRCC3
FAM175A	BRCA2	No	5	BRCC3, BRCA1, BARD1, BRE, FANCG
FAM175A	BARD1	Yes	7	BRE, BARD1, MDC1, UIMC1, PARP1, BRCA1, BRCC3
FAM175A	TP53	No	9	BRE, HSPA4, BARD1, MDC1, UBC, UIMC1, PARP1, BRCA1, BRCC3
FAM175A	ESR1	No	5	PARP1, HSPA4, BRCA1, BARD1, UIMC1
FAM175A	PHB	No	3	PARP1, UBC, BRE
FAM175A	PALB2	No	1	BRCA1
FAM175A	CASP8	No	2	PARP1, UBC
FAM175A	RAD51	No	5	BRCC3, BRCA1, BARD1, BRE, MDC1
NBN	CDH1	No	4	SKP2, EP300, MDM2, XRCC5
NBN	CHEK2	No	11	ATM, ATR, MDM2, MSH2, PRKDC, MDC1, MDM4, RAD50, RNF8, BRCA1, SIRT1
NBN	BRCA1	Yes	38	ATM, ATRIP, FANCD2, TERF1, MDC1, RAD50, RFC1, RECQL5, KAT5, H2AFX, SKP2, DCLRE1C, ATR, CCNE1, BACH1, EP300, MSH2, RPA1, RBBP8, TUBG1, BRCA1, BAP1, TOPBP1, RAD18, MRE11A, PRKDC, TERF2, BARD1, MSH6, SUMO2, UBE2D1, RICTOR, MTOR, BLM, UBE2N, MAPKAP1, MLH1, XRCC5
NBN	BRCA2	No	9	ATM, ATR, BACH1, FANCD2, BARD1, RPA1, MCPH1, BRCA1, H2AFX
NBN	BARD1	Yes	18	MSH6, TOPBP1, BACH1, KAT5, UBE2D1, H2AFX, UBE2N, MSH2, BARD1, MDC1, HIST1H3A, RBBP8, XRCC5, RAD50, BRCA1, MRE11A, SKP2, MLH1
NBN	KRAS	No	1	MED4
NBN	TP53	No	34	ATM, MDM2, H2AFX, SNAI1, MDC1, RPA1, BMI1, SNW1, TUBG1, ATR, BACH1, UBE2B, MSH2, RFC1, OFD1, RPA2, BRCA1, SIRT1, BARD1, KAT5, PRKDC, MSH6, EP300, CELA2B, WRN, HSPA4, UBE2N, MTOR, BLM, MDM4, NCL, ATRX, UBE2A, VRK1
NBN	ESR1	No	18	TOPBP1, KAT5, MDM2, EP300, HSPA4, MSH2, BAP1, BARD1, XRCC5, RAD50, SIRT1, TUBG1, NCL, PRKDC, BRCA1, DDX1, H2AFX, SKP2
NBN	PHB	No	3	ATF2, SKP2, CASC3
NBN	PALB2	No	6	BACH1, SNAI1, RBBP8, NAT2, BRCA1, HIST1H3A
NBN	CASP8	No	3	BLM, BAP1, CASC3
NBN	RAD51	No	19	ATM, FANCD2, ATRX, WRN, RAD18, MSH2, BARD1, BLM, RECQL5, MSH6, TERF2IP, MDC1, MCPH1, RPA1, NAT2, RPA3, BRCA1, H2AFX, TUBG1
NBN	PIK3CA	No	1	ATR
CDH1	CHEK2	No	1	MDM2
CDH1	BRCA1	No	17	XRCC5, HSPA8, CTNNB1, EZR, HDAC2, HDAC1, ACTG1, CREBBP, PPP1CA, JUP, HSP90AA1, CCNB1, HSPD1, POLR2E, EP300, E2F1, SKP2
CDH1	BARD1	No	3	POLR2E, SKP2, XRCC5
CDH1	TP53	No	23	MDM2, CRYAB, CDC42, HSPA5, IQGAP1, MYO6, EP300, SMAD7, LMNA, HSPA9, HDAC1, HSP90AA1, SET, RNF2, PTEN, SRC, GSK3B, HSPA8, PTTG1, CREBBP, HDAC2, PPP1CA, ECT2
CDH1	ESR1	No	28	PTEN, MDM2, HSPD1, KRT8, EGFR, ACTN4, SKP2, MYO6, CBLL1, CTNNB1, E2F1, HDAC1, ACTN1, KRT1, KRT18, HSP90AA1, JUP, SET, AP2M1, SRC, EP300, ANP32B, HSPA8, CREBBP, HDAC2, PPP1CA, POLR2E, XRCC5
CDH1	PHB	No	7	ACTN1, HDAC1, RNF2, LMNA, C1QBP, E2F1, SKP2
CDH1	CASP8	No	5	CASP3, CRYAB, PTEN, GMNN, EZR
CDH1	RAD51	No	3	CASP3, CDC42, HSP90AA1
CDH1	PIK3CA	No	1	HDAC1
CHEK2	BRCA1	Yes	22	ATM, VCP, MAPK1, ITIH5, TP53, RAD50, PLK1, ATR, MSH2, BRCA1, PPP2R5C, ENO1, PRKDC, MDC1, PPP2CA, BRCA2, MAPK3, TP53BP1, KPNA2, RB1, CHEK2, CCAR2
CHEK2	BRCA2	Yes	7	ATM, KAT2B, ATR, PLK1, TP53, BRCA1, CHEK2
CHEK2	BARD1	No	13	UBR5, BRCA2, SRPK1, FOXK2, MSH2, STRAP, MAPK1, MDC1, TP53, RAD50, ELAVL1, SRPK2, BRCA1
CHEK2	KRAS	No	7	IL24, CCL5, PML, MAPK1, ELAVL1, DIRAS3, APP
CHEK2	TP53	Yes	36	ATM, KAT2B, MDC1, VCP, SRPK1, MAPK3, TP53, DAPK3, TP53BP1, RNF20, ATR, MDM2, MSH2, RCHY1, BRCA1, PPP2R5C, SIRT1, VHL, CUL4A, PRKDC, FOXK2, ELAVL1, NR4A1, TRIM28, PPP2R1A, PSME3, FOXK1, UBR5, BRCA2, PLK3, MAPK1, PLK1, RB1, CHEK2, PML, MDM4
CHEK2	ESR1	No	21	KLK9, SRPK2, VCP, PRMT2, SRPK1, PRKDC, MSH2, FOXK2, MAPK1, TP53, CUL1, POLR2L, MDM2, RAD50, WHSC1L1, PPP2CA, PPP2R1A, BRCA1, FOS, PSMC3IP, SIRT1
CHEK2	PHB	No	6	RAB11A, VCP, CCL5, TP53, RB1, ST14
CHEK2	PALB2	No	9	IL24, BRCA2, CCL5, PRDM14, FAM84B, DIRAS3, LYPD3, BRCA1, RHOBTB2
CHEK2	CASP8	No	12	IL24, ST14, PRDM14, MAPK1, KLK9, TP53, RB1, WHSC1L1, CDH13, LYPD3, PSMC3IP, BEX1
CHEK2	RAD51	No	13	ATM, IL24, BRCA2, ST14, ITIH5, MSH2, TP53, MDC1, FAM84B, CDH13, BRCA1, PML, WHSC1L1
CHEK2	PIK3CA	No	4	BEX1, PSMC3IP, ATR, IL24
BRCA1	BRCA2	Yes	29	ATM, BRE, FANCD2, SHFM1, H2AFX, CCNA2, SP1, ATR, BACH1, RPA1, STAT5A, SMAD3, BRCA1, RAD21, PALB2, MORF4L1, BARD1, PMS2, TP53, PCNA, SMC3, CHEK2, BRCC3, HNRNPC, CDK2, FLNA, PLK1, POLH, RAD51
BRCA1	BARD1	Yes	95	PIAS1, HSPA14, UBE2K, BRE, TP53, SNRNP200, PGAM5, COMMD1, MSH2, CDKN2AIP, SNX3, SMC1A, UBXN1, MRE11A, UBE2N, DRG1, CNTN4, MDC1, RELA, RFC2, UBE3A, BRCA2, UBE2D1, SUPT5H, POLR2A, HIST1H2BG, ESR1, RNGTT, RAD51, PARG, GTF3C4, ATP1B3, POLR2H, ASH2L, SKP2, BACH1, PCBP2, HIST2H2AC, UBE2E1, PSMA7, CBX1, AURKA, BRD7, ND1, ATP1B1, FAM175A, PIAS4, KAT5, H2AFX, UBE2W, OLA1, CRIPAK, RBBP8, BRCA1, CSTF1, TOPBP1, MED17, MSH3, NPC2, UIMC1, COL1A1, TULP2, CBX5, CDK2, XRCC6, XIST, CSTF2, XRCC5, CDK1, UBE2E3, RAD50, CBX3, LGALS3, UBE2E2, UBE2D2, TCEB3, MLH1, NPM1, SRSF1, YWHAZ, CDK9, NBN, BARD1, UBE2D3, MTA2, PARP1, MSH6, BRIP1, POLR2E, BRCC3, HNRNPC, MAPK1, YBX1, FBXO5, FBXO44
BRCA1	KRAS	No	4	HNRNPC, MAPK1, DNAJA3, BCL2
BRCA1	TP53	Yes	145	PIAS1, RELA, UBE2K, TFAP4, SUPT6H, RPL28, DDB1, TRIM24, PCNA, PABPC1, UBE3A, MAP3K1, NCOA3, CSNK2B, RPA1, CDK8, FOXO3, SMARCC1, RPL21, BARD1, USP7, NCOA1, TP53, ABL1, GTF2I, GNL3L, BRCA2, CDK2, SKP1, FLNA, MAPK3, PIAS4, PLK1, BLM, ESR1, RAD51, ATM, MYC, NFYA, HNRNPA1, ERCC6, XRCC6, TFAP2C, MTOR, EBNA1BP2, ASH2L, KAT5, TUBG1, SP1, PRMT1, BACH1, RFC1, DNAJB1, NCOA2, NABP2, RPS27, RPS13, CDKN2A, VCP, HERC2, REV1, HSP90AA1, H2AFX, DNAJA1, AURKA, HDAC2, BRD7, MED21, UBC, RPL31, CHEK2, RBBP4, MSH2, HIF1A, BRE, RPS7, CDK1, MDC1, CSNK1D, HECTD3, MSH6, CCNA2, KDM1A, HNRNPA2B1, SUMO1, RBBP7, SMARCD2, SMAD3, ETS1, BRCA1, MED17, PPP1CA, HDAC1, PRKDC, CAPZB, EIF5B, EP300, SMARCA4, RPL3, TP53BP1, WDR48, TP63, CSNK2A1, CHEK1, GTF2H4, TPM3, RB1, RFC4, MNAT1, TPM1, HUWE1, SSX2IP, TFAP2A, YBX1, CDK7, CTBP1, ATR, BCL2, UIMC1, NPM1, SRSF1, DNMT1, PPP2R5C, SMARCB1, YWHAZ, VDR, UBE2N, IFI16, SMARCA5, TOP2A, MTA2, PARP1, RANBP9, TP73, BRCC3, GTF3C4, HSPA8, CREBBP, MAPK1, NINL, CCNH, TUBB, UBE2I, RPRD1A, PPP1R13B
BRCA1	ESR1	Yes	126	PIAS1, AKT1, SMC3, RPL28, NPM1, TRIM24, PGAM5, VCP, MSH2, NCOA3, POLR2D, CDK8, DHX9, RPL3, CTNNB1, BAP1, MKI67, SMC1A, RPL21, SUPT6H, BARD1, JUN, NCOA1, TP53, RELA, UBE3A, SKP1, FLNA, POLR2I, POLR2A, HIST1H2BG, ESR1, POLR2G, RAD51, MYC, HNRNPD, HNRNPA1, PGR, NOP2, NUMA1, EZH2, POLR2H, ASH2L, SKP2, SP1, PRMT1, SNX6, PIK3R1, NCOA2, HIST2H2AC, RPS13, SUZ12, HSP90AA1, SUPT16H, RUVBL2, HSPD1, H2AFX, AHR, HDAC2, TUBB, MED21, PHB2, RBBP4, HIF1A, PABPC1, NFYA, POLR2J, NRIP1, KAT5, KDM1A, POU2F1, RDX, CCND1, STAT5A, RBBP7, HNRNPA2B1, POLR2C, SMAD3, YBX1, BRCA1, TOPBP1, MED17, HDAC1, PRKDC, CAPZB, UIMC1, EP300, SMARCA4, FHL2, SMARCA2, CDK2, XRCC6, CEBPB, RSL1D1, MNAT1, XRCC5, PPP2CA, RAD50, CCNH, DDX54, CDK7, FLII, RPSA, SRSF1, TUBG1, NUP153, E2F1, EIF4G1, LMO4, NELFB, JUP, TOP2A, MTA2, PARP1, NAT10, RANBP9, CRIPAK, UBE2I, HNRNPC, HSPA8, RBM28, CREBBP, MAPK1, GNB2L1, PPP1CA, POLR2E
BRCA1	PHB	No	23	AR, VCP, BRE, SUZ12, SKP2, OLA1, NPM1, E2F1, YWHAZ, ESR1, RBL1, EED, HDAC1, TP53, PARP1, SMARCA2, CDK2, HUWE1, RB1, SMARCA4, UBC, RBL2, PHB2
BRCA1	PALB2	Yes	12	HNRNPC, BRCA2, BACH1, MORF4L1, USP2, MORF4L2, HIST1H2BG, POLH, RBBP8, BRCA1, PALB2, RAD51
BRCA1	CASP8	No	17	BCL2, UBC, USP2, XIAP, MAPK1, BLM, TP53, CEBPB, MSN, RB1, CASP9, YBX1, MAP3K14, PARP1, HECTD3, EZR, BAP1
BRCA1	RAD51	Yes	34	ATM, BRE, PCNA, FANCD2, MDC1, RECQL5, H2AFX, TUBG1, SP1, SUMO1, MSH2, RPA1, HNRNPA2B1, CSNK2B, DNAJA3, BRCA1, ITIH5, BARD1, MORF4L1, RAD18, HSP90AA1, TP53, ABL1, MSH6, UBE2I, BRCC3, HNRNPC, BRCA2, CHEK1, PALB2, BLM, ESR1, NELFB, RAD51
BRCA1	PIK3CA	No	8	ATR, ESR1, LCK, HDAC1, PIK3R1, SMAD3, AKT1, STAT1
BRCA2	BARD1	Yes	12	BRE, CDK2, BACH1, H2AFX, BCCIP, BARD1, HNRNPC, TP53, RAD51, BRCA1, AURKB, BRCC3
BRCA2	KRAS	No	1	HNRNPC
BRCA2	TP53	Yes	26	KAT2B, ATM, BRE, TP53, AURKB, CCNA2, SP1, ATR, BACH1, RAD23A, PSMD6, RPA1, SMAD3, BRCA1, BARD1, SMAD2, PCNA, H2AFX, BRCC3, CDK2, FLNA, USP11, PLK1, SERPINH1, CHEK2, RAD51
BRCA2	ESR1	No	15	SP1, MGMT, SMAD2, CDK2, FLNA, BARD1, HNRNPC, SMC3, STAT5A, SMAD3, TP53, SERPINH1, BRCA1, H2AFX, RAD51
BRCA2	PHB	No	4	MGMT, BRE, CDK2, TP53
BRCA2	PALB2	Yes	9	HNRNPC, BACH1, PALB2, USP11, PDS5B, POLH, BRCA1, MORF4L1, RAD51
BRCA2	CASP8	No	1	TP53
BRCA2	RAD51	Yes	19	SP1, ATM, FANCD2, XRCC3, MORF4L1, DMC1, BARD1, BRE, TP53, HNRNPC, MCPH1, PDS5B, RPA1, PCNA, BRCC3, BRCA1, H2AFX, RAD51, PALB2
BRCA2	PIK3CA	No	3	ATR, SMAD3, SMAD2
BARD1	KRAS	No	4	HNRNPC, MAPK1, ELAVL1, DDX50
BARD1	TP53	Yes	60	UBE2N, CDK1, PIAS1, RELA, UBE2K, FKBP3, CHD3, BRE, MDC1, PIAS4, BRD7, ZHX1, EWSR1, AURKB, ASH2L, MSH6, KAT7, BACH1, MTA2, MSH2, SRSF6, NPM1, SRSF1, BRCC3, MRPS22, YBX1, BRCA1, KPNB1, ESR1, YWHAZ, MED17, ING5, BARD1, KAT5, FOXK2, UBR5, ELAVL1, UIMC1, DCAF7, SRPK1, TRAPPC11, PARP1, H2AFX, UBE3A, MOV10, CCAR1, GTF3C4, BRCA2, AURKA, CDK2, XRCC6, WDR5, MAPK1, THRAP3, NFKBIA, TP53, TOP1, RBM39, WDR33, RAD51
BARD1	ESR1	Yes	63	GOLGA2, SRRM1, PIAS1, MTA2, XRCC6, CCNT1, SRSF2, SRSF5, TP53, THRAP3, RAD50, EWSR1, SRPK2, POLR2H, PGAM5, H2AFX, U2SURP, LUC7L3, DDX50, ASH2L, MSH2, SRSF6, CRIPAK, NPM1, SRSF1, SKP2, BRCA1, HIST2H2AC, ESR1, TOP1, SMC1A, MED17, RBM39, SRSF7, MAPK1, BARD1, SRRM2, FOXK2, SRPK1, AKAP8, UIMC1, RELA, PARP1, BCL3, RPS20, UBE3A, POLR2B, HNRNPC, TOPBP1, LRIF1, KAT5, CDK2, WDR5, U2AF2, TCERG1, YBX1, CIRBP, POLR2A, HIST1H2BG, RAD51, BCLAF1, POLR2E, XRCC5
BARD1	PHB	No	10	BRE, CDK2, OLA1, GTF3C1, TP53, YWHAZ, ESR1, NPM1, PARP1, SKP2
BARD1	PALB2	No	9	HNRNPC, BRCA2, BACH1, RBBP8, MOV10, HIST1H2BG, HIST1H3A, BRCA1, RAD51
BARD1	CASP8	No	6	TRAF1, CHD3, MAPK1, YBX1, TP53, PARP1
BARD1	RAD51	Yes	14	MSH6, HNRNPC, BRE, BRCA2, H2AFX, CHD3, BARD1, RAD51, TP53, MDC1, ESR1, BRCA1, MSH2, BRCC3
BARD1	PIK3CA	No	3	WDR5, RPS20, ESR1
KRAS	TP53	No	9	PHB, CCT7, BCL2, PML, MAPK1, ELAVL1, BTRC, EEF1A1, LIMA1
KRAS	ESR1	No	11	PHB, HNRNPC, CALM1, DDX50, MAPK1, PIK3CA, PIK3R2, TRAF6, BCAS3, SHOC2, SERPINB5
KRAS	PHB	Yes	3	BCAS3, CCL5, RAF1
KRAS	PALB2	No	7	HNRNPC, BCAS3, CCL5, IL24, SERPINB5, DIRAS3, THRSP
KRAS	CASP8	No	7	RALGDS, BCL2, QDPR, MAPK1, IL24, SERPINB5, TRAF6
KRAS	RAD51	No	5	HNRNPC, PML, IL24, ZDHHC17, DNAJA3
KRAS	PIK3CA	Yes	4	THRSP, TNFSF13, IL24, PIK3R2
TP53	ESR1	Yes	211	DDX5, PIAS1, TDG, RPL18A, SUPT6H, TRRAP, RPL28, RPL6, TRIM24, HDAC9, TOP2B, SNRPN, VCP, RPL5, TTK, NCOA3, SKI, CDK8, RBBP5, RPL12, DNMT3L, TOP1, SETD7, HECTD1, G3BP1, BARD1, MYO1C, RPL4, RPS4X, NCOA1, TP53, RELA, RPL11, PRDM2, UBE3A, HIF1A, EP400, PPP1CC, CORO1C, SKP1, FLNA, ANXA2, GNL3, ZBTB16, SFN, RPS2, WDR5, RPL7, RPS26, NFYA, HNRNPA1, IGF1R, EHMT2, RPS8, RRP1B, SAFB, THRAP3, OTUB1, SLC25A5, EWSR1, ARID1A, ASH2L, STUB1, SP1, CLTC, PRMT1, HSP90B1, GTF2H1, GSN, DDX3X, RPL8, RPS16, KAT6A, HSPB1, RPL3, DBN1, HDAC5, YTHDF1, RPS14, HEXIM1, PSMC5, KDM1A, PPARGC1A, ESR1, PIAS2, GAPDH, SIN3A, EIF2S2, RPLP0, HSP90AA1, ACTB, RBBP6, SRPK1, SMURF1, H2AFX, RPL24, RPL7A, MYO6, RBX1, RPS24, HDAC2, RPL23A, TUBB, GADD45A, MED21, RAD51, SERPINH1, RBBP4, MSH2, RPL18, HNRNPK, SIN3B, PABPC1, SRSF6, PARP1, TADA3, RPS6, RPL19, KAT5, RANBP9, CHUK, PHB, RPS18, TFRC, KLF5, HNRNPF, GRWD1, RBBP7, HNRNPA2B1, TUBA1A, SMAD3, MYBBP1A, BRCA1, SIRT1, MED17, SERBP1, RPL14, HDAC1, FOXK2, CCT2, CAPZB, TXNRD1, SET, PTEN, PPP2R1A, TAF1B, EP300, SMARCA4, SMARCD1, NR0B2, CDK2, G3BP2, MEN1, XRCC6, MYH9, PATZ1, RBM39, MNAT1, GNB2, RPS13, SMYD2, MDM2, TBP, MAPK1, S100A8, NCOR1, SAFB2, RPS3, RPS9, CCNH, CDK7, EEF2, MUC1, TAF1A, UIMC1, HNRNPM, NPM1, NCOA2, SRSF1, COPS5, MVP, HSPA1L, TUBA1C, RPL13, NCL, CDKN1A, GTPBP4, PRKDC, RPL21, RPL10A, ALYREF, RPS3A, TOP2A, SMAD2, MTA2, SRC, RPL37A, UBE4B, MYC, HSPA8, CREBBP, MTA1, HSPA4, MED1, YBX1, PPP1CA, MRPS9, SP3, UBE2I, ING1, TUBG1
TP53	PHB	Yes	33	BRE, HSP90AB1, VCP, HUWE1, YWHAE, TP53, RPS4X, SLC25A5, TAT, NCOR1, CLTC, PRKCD, NPM1, SMG5, LMNA, HDAC5, ESR1, YWHAZ, OBSL1, DBN1, HDAC1, SIN3A, RNF2, ACTB, PARP1, CDK2, ANXA2, CCDC8, RB1, RPL7, SMARCA4, UBC, CUL7
TP53	PALB2	No	8	CAPN1, BRCA2, BACH1, SNAI1, USP11, MOV10, BRCA1, RAD51
TP53	CASP8	Yes	28	TNFAIP3, TOPORS, BAX, TP53, VIM, CFLAR, HECTD3, CHUK, MAPK8, MAP1LC3B, PARK7, BLM, RNF34, BIRC6, CHD3, SQSTM1, CRYAB, SNRPD3, IKBKB, PTEN, PARP1, CASP8, BCL2, MAPK1, TSC22D3, YBX1, RB1, UBC
TP53	RAD51	Yes	33	ATM, USP10, PCNA, CHD3, BRE, MDC1, VIM, H2AFX, TUBG1, SP1, SUMO1, MSH2, BLM, RPA1, HNRNPA2B1, CSNK2B, BRCA1, BARD1, HSP90AA1, TP53, ABL1, MSH6, UBE2I, BRCC3, BRCA2, WRN, CHEK1, UHRF2, ESR1, CDC42, ATRX, PML, RAD51
TP53	PIK3CA	No	16	UFD1L, DDX5, ESR1, CRK, GSN, HRAS, PCBP1, WDR5, SMAD2, ATR, SMAD3, IRS4, DNAJB6, APPL1, HDAC1, SQSTM1
ESR1	PHB	Yes	37	ATP5B, VCP, TP53, SUZ12, MYOD1, RPS4X, MTCH2, SLC25A5, SKP2, MED20, CLTC, PHB2, NPM1, SYNCRIP, NCOR1, DBN1, HDAC5, HDAC1, BCAS3, ESR1, ACTN1, MED23, SIN3A, MGMT, ACTB, XPO1, PARP1, PLEC, E2F1, STAU1, SMARCA2, CDK2, FUS, ANXA2, RPL7, SMARCA4, CUL3
ESR1	PALB2	No	7	HNRNPC, BCAS3, SERPINB5, HIST1H2BG, CUL3, BRCA1, RAD51
ESR1	CASP8	No	24	ARHGDIA, TP53, CHUK, NR1H4, KLK9, KLK5, KHDRBS1, HDAC7, BAP1, HBP1, SERPINB5, GLCE, TRAF6, PTEN, PARP1, PSMC3IP, WHSC1L1, MAPK1, YBX1, CEBPB, EPSTI1, ATAD2, ANGPTL4, CUL3
ESR1	RAD51	Yes	18	SP1, UBE2I, FBXO18, PFN1, H2AFX, MSH2, BARD1, RAD51, TP53, HNRNPA2B1, HNRNPC, ELMSAN1, TUBG1, ESR1, NELFB, HSP90AA1, BRCA1, WHSC1L1
ESR1	PIK3CA	Yes	15	DDX5, SMAD2, AKT1, HDAC1, GSN, UBTF, PIK3R2, PSMC3IP, PIK3R1, SMAD3, IRS1, ESR1, IRS2, RPS20, WDR5
PHB	PALB2	No	3	BCAS3, CCL5, CUL3
PHB	CASP8	No	8	TP53, UBC, RB1, CUL3, ST14, PARP1, BCAP31, CASC3
PHB	RAD51	No	5	RAB5C, BRE, ESR1, ST14, TP53
PHB	PIK3CA	No	4	NTRK1, HDAC1, KRAS, ESR1
PALB2	CASP8	No	9	IL13RA2, IL24, ERRFI1, SERPINB5, CUL3, GREB1, LYPD3, PRDM14, USP2
PALB2	RAD51	Yes	12	IL24, BRCA2, MORF4L1, PALB2, HNRNPC, FAM84B, PDS5B, CST6, NAT2, BRCA1, RAD51AP1, RAD51
PALB2	PIK3CA	No	3	IL13RA2, IL24, THRSP
CASP8	RAD51	No	10	IL24, UMPS, CHD3, TP53, CASP3, BLM, VIM, CDH13, WHSC1L1, ST14
CASP8	PIK3CA	No	8	IL13RA2, TNFRSF1A, FASLG, BEX1, UMPS, PSMC3IP, IL24, SQSTM1
RAD51	PIK3CA	No	4	UMPS, IL24, BUB1, ESR1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
ATM	TP53	Yes	0
NQO2	KRAS	Yes	1	KRAS
BRCA1	TP53	No	2	CREBBP, EP300
BRCA1	RAD51	Yes	0
KRAS	TP53	No	1	EXOSC4
KRAS	CASP8	No	1	NOL3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
TSG101	HMMR	No	-	2	AR, TP53
TSG101	NQO2	No	-	1	UBC
TSG101	AKT1	No	-	12	CDKN1A, KRAS, MDM2, AR, RPS27A, TP53, SOS1, USP8, UBC, GRB2, UBB, NEDD4
TSG101	BRIP1	No	-	1	UBC
TSG101	RB1CC1	No	-	2	UBC, TP53
TSG101	PPM1D	No	-	3	UBC, TP53, MDM2
TSG101	FAM175A	No	-	1	UBC
TSG101	CDH1	No	-	7	AR, MDM2, HGS, TP53, EGF, EGFR, UBC
TSG101	CHEK2	No	-	4	UBC, CDKN1A, MDM2, TP53
TSG101	BRCA1	No	-	5	TP53, UBC, CDKN1A, AR, PABPC1
TSG101	BRCA2	No	-	2	AR, TP53
TSG101	BARD1	No	-	2	UBC, TP53
TSG101	KRAS	Yes	binding	6	SOS1, EGF, TP53, EGFR, UBC, GRB2
TSG101	TP53	Yes	activation, binding	12	MAP9, RPS27A, MDM2, NR3C1, AR, UBA52, CDKN1A, KRAS, EGFR, UBC, UBB, CEP55
TSG101	SLC22A18	No	-	1	UBC
TSG101	ESR1	No	-	9	CDKN1A, MDM2, NR3C1, AR, TP53, SOS1, EGFR, UBC, GRB2
TSG101	PHB	No	-	2	UBC, TP53
TSG101	RAD51	No	-	1	TP53
TSG101	PIK3CA	No	-	8	AR, KRAS, NR3C1, TP53, SOS1, EGFR, EGF, GRB2
HMMR	AKT1	No	-	6	AR, SLC9A1, HRAS, AURKA, TP53, CD44
HMMR	RB1CC1	No	-	1	TP53
HMMR	PPM1D	No	-	1	TP53
HMMR	CDH1	No	-	4	CD44, MTA1, AR, TP53
HMMR	CHEK2	No	-	1	TP53
HMMR	BRCA1	No	-	4	AR, AURKA, TP53, BACH1
HMMR	BRCA2	No	-	2	AR, TP53
HMMR	BARD1	No	-	3	AURKA, TP53, BACH1
HMMR	KRAS	No	-	2	HRAS, TP53
HMMR	TP53	Yes	binding, activation, expression	6	AR, HRAS, AURKA, MTA1, CSNK1A1, CD44
HMMR	ESR1	No	-	3	AR, MTA1, TP53
HMMR	PHB	No	-	1	TP53
HMMR	RAD51	No	-	1	TP53
HMMR	PIK3CA	No	-	3	HRAS, AR, TP53
NQO2	AKT1	No	-	1	UBC
NQO2	BRIP1	No	-	1	UBC
NQO2	RB1CC1	No	-	1	UBC
NQO2	PPM1D	No	-	1	UBC
NQO2	FAM175A	No	-	1	UBC
NQO2	CDH1	No	-	1	UBC
NQO2	CHEK2	No	-	1	UBC
NQO2	BRCA1	No	-	1	UBC
NQO2	BARD1	No	-	1	UBC
NQO2	KRAS	No	-	1	UBC
NQO2	TP53	No	-	1	UBC
NQO2	SLC22A18	No	-	1	UBC
NQO2	ESR1	No	-	1	UBC
NQO2	PHB	No	-	1	UBC
AKT1	BRIP1	No	-	4	UBC, BRCA1, TOPBP1, FOXM1
AKT1	RB1CC1	No	-	8	RPS6KB1, MLST8, SMAD7, RPTOR, MTOR, RB1, TP53, UBC
AKT1	PPM1D	No	-	10	BCL2L1, MDM2, RUNX2, CHEK1, TP53, JUN, UBC, MAPK14, PAK1, MDM4
AKT1	FAM175A	No	-	2	UBC, BRCA1
AKT1	CDH1	Yes	activation, binding	80	ZYX, CDH2, FOXM1, SNAI2, POSTN, ACTA1, TP53, SNAI1, RAC1, SMAD4, CAV1, FOXA2, GLI2, SERPINE1, CTGF, FOXO3, EZR, FOS, FGF2, SKP2, PTGS2, IQGAP1, CD44, PDCD4, ITGA6, ITGB4, NFKB1, RHOA, SMAD7, PIK3R1, PIK3CA, RAP1A, HDAC9, SMAD3, CTNNB1, TGFB1, ERBB3, LEP, CDC42, WT1, NOTCH1, STAT5A, RAP1B, GLI1, MDM2, F2R, AR, SLC3A2, IQGAP2, GAB2, IGF1, RPS6KB1, JUN, VAV1, PTEN, SRC, EP300, EFNA1, DLC1, STAT3, SMAD2, FGF13, RPTOR, BCL2, ILK, RICTOR, PRKCZ, MMP9, IGF2, RB1, TJP1, STAT5B, RAC3, EZH2, UBC, IRS2, MYC, CCND1, NOX1, FOXA1
AKT1	CHEK2	No	-	15	KAT2B, CDKN1A, MDM2, FOXM1, CHEK1, YWHAH, PPP2CA, TP53, MDM4, RB1, YWHAZ, SFN, UBC, BRCA1, CDC25C
AKT1	BRCA1	Yes	binding	38	AR, TERF1, TOPBP1, TP53, NPM1, BMI1, PCGF2, SKP2, CCND1, RB1, CREB1, STAT5A, SMAD3, CCNA2, CTNNB1, E2F1, SIRT1, CDKN1A, ESR1, HSP90AA1, JUN, ATF2, RELA, SRC, EP300, FANCA, HSPA8, UBE2D1, CREBBP, AURKA, PPP1CA, GADD45A, PIK3R1, HIF1A, CCNB1, UBC, MYC, CDKN1B
AKT1	BRCA2	No	-	9	AR, C11ORF30, CHEK1, FANCA, TP53, STAT5A, SMAD3, BRCA1, SNAI2
AKT1	BARD1	No	-	10	TOPBP1, UBE2D1, AURKA, FANCA, TP53, ESR1, UBC, BMI1, PCGF2, BRCA1
AKT1	KRAS	Yes	activation, binding	40	BCL2L1, PTPN11, TP53, SPHK1, NPM1, PIK3CG, LGALS3, VEGFA, YWHAB, HSP90AA1, GRB2, ANGPT1, BCL2, CCND1, PIK3CA, ERBB3, RAF1, SOS1, SHC1, AKT2, SLC3A2, HRAS, RALGDS, BTRC, RPS6KB1, JUN, PPP2CA, CTGF, SRC, BCL2L11, MAPK14, NOTCH1, PIK3CB, MTOR, IRS2, UBC, IRS1, PIK3CD, BRAF, MDM4
AKT1	TP53	Yes	binding, activation, expression	139	WWOX, RELA, CAV1, NPM1, HDAC9, VEGFA, FOXO3, HTT, CXCL12, STAT5A, COPS5, MAPK14, BAX, BDNF, JUN, NR4A1, FOXM1, MMP9, MTOR, MCL1, YWHAG, ESR1, KAT2B, BCL2L1, RUNX2, YWHAE, IGFBP3, SERPINE1, FGF2, STUB1, PTGS2, PIAS2, EGR1, PARK7, THBS1, RB1, CAT, CCNA2, SFN, TSC2, GAPDH, AR, CDH1, ANKRD2, HSP90AA1, LGALS3, AURKA, TERT, MMP2, GADD45A, S100B, MDM4, CCNB1, UBC, HIF1A, SP7, MMP1, SLC2A4, SMAD4, BTRC, CREB1, CFLAR, HSPA5, FOS, NCOR1, PHB, NOS3, PHF20, GDF15, NFKB1, CCND1, CD44, KRAS, BMI1, AXIN1, SMAD3, RAF1, BRCA1, SIRT1, WT1, BIRC5, FOXO1, HSPB3, HRAS, NOTCH1, SMAD2, NFE2L2, PTEN, PPP2R1A, ICAM1, EP300, SHH, UBE2D1, CHEK1, EZH2, RUNX3, APAF1, HMOX1, CDC25C, PTPN11, MDM2, HSPB2-C11ORF52, SNAI1, TOPBP1, SNAI2, WEE1, BAIAP2L1, UBB, RPS27A, BCL2, SMAD7, PPP2R4, PIK3CA, CLU, DNMT1, SKP2, TGFB1, PPP2R5C, YWHAZ, CDKN1A, SERPINH1, TRAF6, STAT5B, CTGF, PARP1, GSK3B, MYC, STAT3, HSPA8, POLI, CREBBP, HSPA4, IKBKB, YBX1, IL6, ATIC, LEP, MAP3K8, PDCD4
AKT1	SLC22A18	No	-	1	UBC
AKT1	ESR1	Yes	activation, binding	84	MYC, AR, PELP1, PTEN, MDM2, RRAS2, RAC3, EZH2, CDKN1A, TP53, NOS3, SRC, CAV1, MAPK14, ATF2, SOS1, GNB1, CTGF, NRIP1, HDAC9, FOS, VEGFA, STUB1, PHB, GNAI3, PTGES3, FOXO3, RXRG, FOXM1, STRN, GNAO1, GNAI1, CXCL12, MAPT, HDAC3, PIK3CA, NCOR2, STAT5A, SMAD3, NCOR1, SMAD2, COPS5, SHC1, FOXO4, SIRT1, TSC2, AKT2, FOXO1, SOD1, GAPDH, TERT, STAT3, RARA, MYOD1, HSP90AA1, JUN, NR4A1, SMAD4, RELA, RHOA, PARP1, PAK1, EP300, BRCA1, E2F1, FKBP5, FKBP4, HSPA8, CREBBP, HSPA4, SNAI2, FASN, HEXIM1, INS, IL6, PIK3R1, GNAZ, IGF1, UBC, IRS1, GRB2, LEP, CCND1, FOXA1
AKT1	PHB	Yes	binding, ptmod	9	RAF1, TP53, RB1, NCOR1, ESR1, UBC, E2F1, VDAC1, YWHAZ
AKT1	PALB2	No	-	1	BRCA1
AKT1	RAD51	No	-	8	EGR1, FOXM1, CHEK1, IRS1, POLI, TP53, BRCA1, BCR
AKT1	PIK3CA	Yes	activation, binding	108	ITGB3, PTEN, PLCG1, TP53, CDC42, SOS1, RAP1A, PDGFB, ACTN4, PDGFRB, ACTA1, CTNNB1, GNGT1, BECN1, BDNF, PIK3CB, RELA, CBLB, RELN, IL2, RRAS2, MTOR, INS, JAK1, PIK3R5, GNB1, ESR1, VAV2, FLT3, BCL2L1, AKT2, ITGA2B, RPTOR, PGF, ANGPT2, ITGA6, RHOA, PREX1, PIK3R1, BCR, RPS6KB2, APPL1, IGF1, PTPN1, CDH1, PIK3R3, PDPK1, ITGB4, GRB2, GAB1, PIK3CD, ZYX, PELP1, VLDLR, AR, CSK, TPTE2, RAP1B, DAB1, INSR, GSK3B, CCND1, CREB1, SMAD3, RAF1, ERBB3, TPTE, LCK, HRAS, NOTCH1, GAB2, DOK1, CDH2, VEGFA, RAC1, RICTOR, PRKCZ, GNAI3, CASP9, IL2RB, EFNA1, RAC3, PTPN11, MAP3K5, PIK3CG, GNAI1, DAB2IP, ANGPT1, RRAS, SHC1, YWHAZ, CSF2, TSC1, S1PR1, SLC9A3R1, SMAD2, SRC, NFKB1, MYC, STAT3, KRAS, IL3, ARF6, RPS6KB1, IRS1, VAV1, IRS2, LAT
BRIP1	XRCC3	No	-	3	BLM, BRCA2, MLH1
BRIP1	RB1CC1	No	-	1	UBC
BRIP1	PPM1D	No	-	1	UBC
BRIP1	RAD54L	No	-	1	BLM
BRIP1	FAM175A	No	-	2	UBC, BRCA1
BRIP1	CDH1	No	-	2	UBC, FOXM1
BRIP1	CHEK2	No	-	5	UBC, BRCA1, BRCA2, FOXM1, PLK1
BRIP1	BRCA1	Yes	binding	8	TOPBP1, BRCA2, PALB2, RPA1, BLM, PLK1, UBC, MLH1
BRIP1	BRCA2	Yes	binding	7	PALB2, RPA1, BLM, PLK1, BRCA1, TOP3A, MLH1
BRIP1	BARD1	No	-	3	UBC, BRCA1, TOPBP1
BRIP1	KRAS	No	-	1	UBC
BRIP1	TP53	No	-	11	TOPBP1, BRCA2, FOXM1, ERCC2, MLH1, PMS2, RPA1, BLM, PLK1, UBC, BRCA1
BRIP1	SLC22A18	No	-	1	UBC
BRIP1	ESR1	No	-	3	UBC, BRCA1, FOXM1
BRIP1	PHB	No	-	1	UBC
BRIP1	PALB2	Yes	binding	2	BRCA1, BRCA2
BRIP1	RAD51	No	-	10	PMS2, BRCA2, FOXM1, PALB2, RPA1, BLM, PLK1, BRCA1, TOP3A, MLH1
XRCC3	PPM1D	No	-	0
XRCC3	RAD54L	Yes	binding	8	WRN, DMC1, BLM, RAD51, RAD51C, RECQL, RAD51B, RAD51D
XRCC3	FAM175A	No	-	0
XRCC3	CHEK2	No	-	3	RAD52, BRCA2, WRN
XRCC3	BRCA1	No	-	11	ACACA, BRCA2, MLH1, BLM, FANCG, RAD51C, RAD51B, POLH, DMC1, RAD51, FANCD2
XRCC3	BRCA2	Yes	activation, binding	9	FANCD2, RAD51D, MLH1, BLM, FANCG, RAD51C, RAD51B, DMC1, RAD51
XRCC3	BARD1	No	-	3	FANCD2, RAD51, FANCG
XRCC3	TP53	No	-	6	BRCA2, WRN, MLH1, BLM, POLH, RAD51
XRCC3	PALB2	No	-	4	FANCD2, BRCA2, RAD51, RAD51C
XRCC3	RAD51	Yes	binding	16	FBXO18, BRCA2, BLM, WRN, MLH1, DMC1, ACACA, TTF2, RAD54B, ACACB, REV1, RAD52, RAD54L, POLH, RECQL, RAD51C
RB1CC1	PPM1D	No	-	2	UBC, TP53
RB1CC1	FAM175A	No	-	1	UBC
RB1CC1	CDH1	No	-	6	RPS6KB1, SMAD7, RPTOR, TP53, RB1, UBC
RB1CC1	CHEK2	No	-	3	UBC, RB1, TP53
RB1CC1	BRCA1	No	-	4	UBC, SMARCB1, RB1, TP53
RB1CC1	BRCA2	No	-	1	TP53
RB1CC1	BARD1	No	-	2	UBC, TP53
RB1CC1	KRAS	No	-	5	MTOR, UBC, RPS6KB1, PTK2, TP53
RB1CC1	TP53	Yes	activation, binding	8	PTK2B, SMAD7, PIAS4, MTOR, RB1, PTK2, UBC, SMARCB1
RB1CC1	SLC22A18	Yes	binding	1	UBC
RB1CC1	ESR1	No	-	2	UBC, TP53
RB1CC1	PHB	No	-	3	UBC, RB1, TP53
RB1CC1	RAD51	No	-	1	TP53
RB1CC1	PIK3CA	No	-	5	MTOR, RPTOR, RPS6KB1, TP53, PTK2
PPM1D	FAM175A	No	-	2	UBC, H2AFX
PPM1D	CDH1	No	-	5	UBC, JUN, MAPK3, TP53, MDM2
PPM1D	CHEK2	Yes	binding, ptmod	6	MDM2, CHEK1, TP53, UBC, H2AFX, MDM4
PPM1D	BRCA1	No	-	5	UBC, CHEK2, H2AFX, JUN, TP53
PPM1D	BRCA2	No	-	4	CHEK2, CHEK1, H2AFX, TP53
PPM1D	BARD1	No	-	3	UBC, H2AFX, TP53
PPM1D	KRAS	No	-	10	BCL2L1, MAPK11, MAPK3, TP53, JUN, MAPK13, UBC, MAPK14, MAPK12, MDM4
PPM1D	TP53	Yes	activation	15	BCL2L1, MAPK11, RUNX2, CHEK1, MAPK3, MAPK13, JUN, MAPK12, MDM2, UBC, CHEK2, H2AFX, HIPK2, MAPK14, MDM4
PPM1D	SLC22A18	No	-	1	UBC
PPM1D	ESR1	No	-	8	MDM2, MAPK11, MAPK3, TP53, JUN, UBC, MAPK14, PAK1
PPM1D	PHB	No	-	2	UBC, TP53
PPM1D	RAD51	No	-	3	H2AFX, CHEK1, TP53
PPM1D	PIK3CA	No	-	2	BCL2L1, TP53
RAD54L	CHEK2	No	-	2	MUS81, WRN
RAD54L	BRCA1	No	-	5	RAD51B, BLM, RAD51, DMC1, RAD51C
RAD54L	BRCA2	No	-	7	RAD51D, DMC1, BLM, RAD51, XRCC3, RAD51B, RAD51C
RAD54L	BARD1	No	-	1	RAD51
RAD54L	TP53	No	-	3	BLM, RAD51, WRN
RAD54L	PALB2	No	-	2	RAD51, RAD51C
RAD54L	RAD51	Yes	binding	6	WRN, DMC1, BLM, XRCC3, RECQL, RAD51C
FAM175A	CDH1	No	-	1	UBC
FAM175A	CHEK2	No	-	6	TP53BP1, RAD50, UBC, BRCA1, H2AFX, RNF8
FAM175A	BRCA1	Yes	binding	10	BRE, BABAM1, BARD1, TP53BP1, UIMC1, RAD50, UBC, H2AFX, SUMO2, RNF8
FAM175A	BRCA2	No	-	2	BRCA1, H2AFX
FAM175A	BARD1	Yes	binding	7	BRE, BABAM1, UIMC1, RAD50, UBC, BRCA1, H2AFX
FAM175A	KRAS	No	-	1	UBC
FAM175A	TP53	No	-	7	BARD1, TP53BP1, UIMC1, UBC, BRCA1, SUMO2, H2AFX
FAM175A	SLC22A18	No	-	1	UBC
FAM175A	ESR1	No	-	3	UBC, BRCA1, BARD1
FAM175A	PHB	No	-	2	UBC, BRE
FAM175A	PALB2	No	-	1	BRCA1
FAM175A	RAD51	No	-	6	BRE, BARD1, TP53BP1, BRCA1, SUMO2, H2AFX
CDH1	CHEK2	No	-	6	VHL, FOXM1, MDM2, TP53, RB1, UBC
CDH1	BRCA1	No	-	27	AR, AKT1, TP53, ANAPC11, CTBP1, SKP2, SUMO1, CCND1, RB1, CDC27, STAT5A, SMAD3, CTNNB1, CDC23, HDAC1, JUN, ABL1, SRC, EP300, FHL2, ANAPC7, HDAC2, CBX7, PIK3R1, SMARCA4, UBC, MYC
CDH1	BRCA2	No	-	5	TP53, SNAI2, SMAD3, STAT5A, AR
CDH1	BARD1	No	-	7	ANAPC7, TP53, CBX7, CDC27, ANAPC11, UBC, CDC23
CDH1	KRAS	No	-	31	AKT1, BMP4, MAPK3, RET, TP53, EGFR, CTGF, IGF2BP1, BCL2, CCND1, PIK3CA, EPHA2, ERBB2, ERBB3, KIT, IRS2, SLC3A2, PRMT5, UBC, RPS6KB1, IL8, ABL1, SRC, FYN, YES1, NOTCH1, MAPK1, JUN, CDX1, CDX2, EGF
CDH1	TP53	Yes	activation, binding	83	PKD1, VHL, AR, ABL1, FOXM1, BCL2, MET, MAPK3, ZEB2, SNAI1, HOXA10, TWIST1, SMAD4, CAV1, RGCC, MTA3, NRP2, SERPINE1, CTGF, HDAC9, FOS, FGF2, SKP2, PTGS2, CD44, ID2, MDM2, SUMO1, CTCF, NFKB1, KLF5, SMAD7, RB1, PIK3CA, EPHA2, ERBB2, SMAD3, FHL2, CD82, TGFB1, TGM2, NUMB, WT1, PPARGC1A, STAT5A, CA9, HGF, MAPK1, CCNG1, HDAC1, PRMT5, STAT3, SMAD2, JUN, S100A4, PSEN1, AKT1, SIK1, HMGA2, EP300, FOXO3, SNAI2, NOTCH1, EGFR, MYO6, SIRT3, STAT5B, CCND1, IGF1R, MTA1, HDAC2, EZH2, CTBP1, MMP9, PTEN, SMARCA4, UBC, MYC, LEP, PPARG, KLF4, PDLIM7, PDCD4
CDH1	SLC22A18	No	-	1	UBC
CDH1	ESR1	No	-	53	AR, ABL1, FOXM1, HDAC2, TP53, MAPK1, TWIST1, CAV1, EGFR, CTGF, HDAC9, FOS, MDM2, SUMO1, CTBP1, RHOA, ERBB2, PIK3CA, MTA1, SMAD3, CD82, MACROD1, FOXO3, GNA13, PPARGC1A, STAT5A, IGF1, ESR2, HDAC1, SMAD2, JUN, SMAD4, AKT1, SRC, MTA3, EP300, LEP, SNAI2, STAT3, WNT7A, IGF1R, MAPK3, EZH2, PIK3R1, PTEN, FOXA1, SMARCA4, UBC, MYC, CCND1, PPARG, KLF5, RAC3
CDH1	PHB	No	-	6	AKT1, HDAC1, TP53, RB1, SMARCA4, UBC
CDH1	RAD51	No	-	5	SUMO1, TP53, FOXM1, SMARCA4, ABL1
CDH1	PIK3CA	Yes	activation, binding	58	RAC1, CDH2, MET, CD2AP, RET, ZYX, VCL, ACTN1, CTNND1, CDC42, EGFR, RAP1B, DLG1, HGF, ITGA6, GFRA1, ITGB4, RHOA, ACTA1, CTNNA1, RAP1A, EPHA2, ERBB2, SMAD3, TLN1, CTNNB1, ERBB3, KIT, PRKCA, PRKCI, AR, NOTCH1, GAB2, TP53, RPS6KB1, SMAD2, AKT1, SRC, FYN, NFKB1, EFNA1, YES1, STAT3, GDNF, IL4, RICTOR, VAV1, PRKCZ, RPTOR, PIK3R1, PTEN, IGF1, EGF, IRS2, MYC, CCND1, IGF1R, RAC3
CHEK2	BRCA1	Yes	activation, binding	15	TP53BP1, ATR, TREX1, MSH2, TOP2A, CDKN1A, PLK1, RB1, RAD50, TP53, UBC, BRCA2, H2AFX, TP73, RNF8
CHEK2	BRCA2	Yes	binding, ptmod	7	ATR, TREX1, CHEK1, PLK1, TP53, H2AFX, BRCA1
CHEK2	BARD1	No	-	7	ATR, MSH2, TP53, RAD50, UBC, H2AFX, BRCA1
CHEK2	KRAS	No	-	4	UBC, TP53, PPP2CA, MDM4
CHEK2	TP53	Yes	activation, binding	33	KAT2B, PLK3, TREX1, MDM2, CHEK1, CDC25A, TP53BP1, ATR, FOXM1, MSH2, PPM1D, RCHY1, BRCA1, YWHAZ, VHL, CDKN1A, ELAVL1, TOP2A, H2AFX, BRCA2, TP63, WRN, CABIN1, ASF1A, PLK1, KPNA2, RB1, MDM4, SFN, UBC, TP73, PML, CDC25C
CHEK2	SLC22A18	No	-	1	UBC
CHEK2	ESR1	No	-	7	CDKN1A, MDM2, FOXM1, MSH2, TP53, UBC, BRCA1
CHEK2	PHB	No	-	4	UBC, RB1, TP53, YWHAZ
CHEK2	PALB2	No	-	2	BRCA1, BRCA2
CHEK2	RAD51	No	-	11	TP53BP1, BRCA2, FOXM1, WRN, MSH2, CHEK1, PLK1, TP53, RAD52, H2AFX, BRCA1
CHEK2	PIK3CA	No	-	2	TP53, YWHAZ
BRCA1	BRCA2	Yes	binding	32	AR, TREX1, H2AFX, FANCD2, SHFM1, TEX15, HIST3H3, RPA3, RAD51B, ATR, MLH1, RAD51, RPA1, STAT5A, SMAD3, RPA2, PALB2, FANCI, DMC1, TP53, PSMC3IP, BRIP1, FANCA, CDK2, CDK4, BUB1B, PLK1, BLM, FANCG, MND1, CHEK2, RAD51C
BRCA1	BARD1	Yes	binding	65	ANAPC4, CDC26, ANAPC11, UBE2L3, H2AFX, AURKA, FANCD2, BRE, ANAPC15, FAM175A, FANCE, PHC2, RAD50, ANAPC13, CBX2, PCNA, BMI1, BABAM1, UBE2D2, CCNE1, CUL7, BACH1, PCGF2, MSH2, RAD51, ANAPC2, CDC27, PCGF6, CSTF1, FANCF, CBX8, RBBP8, ANAPC5, ANAPC16, CDC23, TOPBP1, CBX4, UBE2C, CDK2, UBE2N, ATR, UBE2D3, ANAPC7, UIMC1, CDC16, FANCC, RBX1, MSH6, PHC1, ANAPC1, ANAPC10, FANCA, RNF2, UBE2S, UBE2D1, FANCL, BUB1B, CBX7, TP53, FANCG, ESR1, UBC, CSTF2, PHC3, XRCC5
BRCA1	KRAS	No	-	9	ABL1, CCND1, TP53, UBC, JUN, HSP90AA1, AKT1, NPM1, SRC
BRCA1	TP53	Yes	activation, binding	82	STAG2, AURKA, TREX1, CDK2, UBE2K, PCNA, NCOA3, TOPORS, RPA1, SMARCB1, MNAT1, CDK4, POLH, ERCC6, CDK1, BMI1, CTBP1, MSH6, SKP2, SP1, TERF2, AR, E2F4, SUMO1, TP73, EP300, CCND1, ABL1, STAT5A, CREB1, CDK8, SRSF1, TFDP1, CCNA2, SMAD3, SUMO3, SIRT1, UBE2I, CDKN1A, CCNB1, SMARCA4, ZNF148, TOPBP1, VDR, UBE2N, HDAC1, RB1, BARD1, ATR, RNF2, HSP90AA1, JUN, TOP2A, RAD51, AKT1, NPM1, RPA3, BRCA2, H2AFX, SUMO2, CHEK2, FHL2, TP53BP1, USP7, MSH2, HSPA8, XRCC5, UBE2D1, CCNA1, CREBBP, HDAC2, UIMC1, PLK1, GADD45A, BLM, HIF1A, ESR1, UBC, MYC, RELA, MLH1, CUL7
BRCA1	SLC22A18	No	-	1	UBC
BRCA1	ESR1	Yes	binding	44	AR, AKT1, TP53, ATF2, PGR, PCNA, SP1, SUMO1, CTBP1, MSH2, NCOA3, POLR2A, STAT5A, SMAD3, AHR, NCOA2, E2F1, SIRT1, UBE2I, CDKN1A, MED17, GTF2E1, VDR, HDAC1, BARD1, COBRA1, HSP90AA1, JUN, LMO4, ABL1, SRC, EP300, MNAT1, SMARCA2, HSPA8, CREBBP, HDAC2, PIK3R1, GTF2F1, SMARCA4, UBC, MYC, RELA, CCND1
BRCA1	PHB	No	-	11	SMARCA2, AKT1, HDAC1, BRE, RNF2, RB1, TP53, ESR1, UBC, E2F1, SMARCA4
BRCA1	PALB2	Yes	binding	8	FANCI, BRCA2, MORF4L1, RBBP8, RAD51C, BRIP1, FANCD2, RAD51
BRCA1	RAD51	Yes	activation, binding	34	BRE, HIST3H3, ABL1, H2AFX, PALB2, ACACA, TP53, TEX15, TP53BP1, RPA3, MSH6, SUMO1, MSH2, RPA1, RPA2, MND1, RAD18, DMC1, BARD1, SMARCA2, CDK4, PCNA, PSMC3IP, SUMO2, UBE2I, MSH3, BRCA2, CDK2, PLK1, BLM, SMARCA4, POLH, MLH1, RAD51C
BRCA1	PIK3CA	No	-	14	SP1, AR, CTNNB1, CCND1, RELA, CREB1, PIK3R1, SMAD3, TP53, ESR1, SRC, PGR, AKT1, MYC
BRCA2	BARD1	No	-	11	AURKB, FANCA, CDK2, FANCD2, BUB1B, ATR, TP53, RAD51, BRCA1, H2AFX, FANCG
BRCA2	KRAS	No	-	1	TP53
BRCA2	TP53	Yes	activation, binding	20	AURKB, AR, STAT5A, TREX1, CDK2, CDK4, BCCIP, CHEK1, ATR, RPA1, BLM, SMAD3, PLK1, RPA3, SNAI2, CHEK2, H2AFX, BRCA1, RAD51, MLH1
BRCA2	ESR1	No	-	6	AR, STAT5A, TP53, SNAI2, SMAD3, BRCA1
BRCA2	PHB	No	-	1	TP53
BRCA2	PALB2	Yes	binding	6	FANCI, FANCD2, RAD51, BRCA1, BRIP1, RAD51C
BRCA2	RAD51	Yes	activation, binding	24	HIST3H3, PALB2, TP53, TEX15, MSH4, XRCC3, RPA3, TOP3A, PSMC3IP, MLH1, RPA1, MCPH1, RPA2, BRCA1, DMC1, CDK4, H2AFX, CDK2, CHEK1, PLK1, BLM, MLH3, MND1, RAD51C
BRCA2	PIK3CA	No	-	3	AR, SMAD3, TP53
BARD1	KRAS	No	-	2	UBC, TP53
BARD1	TP53	Yes	activation, binding	22	AURKB, XRCC6, EWSR1, BMI1, MSH6, ATR, MSH2, BRCA1, TOPBP1, UBE2N, RNF2, UIMC1, PCNA, H2AFX, CDK2, UBE2D1, AURKA, XRCC5, CUL7, ESR1, UBC, RAD51
BARD1	SLC22A18	No	-	1	UBC
BARD1	ESR1	Yes	binding	5	UBC, BRCA1, MSH2, TP53, PCNA
BARD1	PHB	No	-	5	UBC, BRE, ESR1, TP53, RNF2
BARD1	PALB2	No	-	4	BRCA1, RBBP8, FANCD2, RAD51
BARD1	RAD51	Yes	binding	8	MSH6, BRE, CDK2, MSH2, TP53, PCNA, H2AFX, BRCA1
BARD1	PIK3CA	No	-	2	ESR1, TP53
KRAS	TP53	Yes	activation, binding	40	BCL2L1, ABL1, MAPK1, PTPN11, ETS2, BTRC, NPM1, EGFR, HBEGF, LGALS3, PRMT1, MAPK11, CTGF, CCND1, PTK2, MDM4, EPHA2, ERBB2, RAF1, MAPK14, MAPK7, NCL, HRAS, PRMT5, NOTCH1, MAPK13, JUN, HSP90AA1, AKT1, VEGFA, MAPK12, ETS1, MGMT, BCL2, MAPK3, MTOR, ERBB4, PIK3CA, UBC, TSG101
KRAS	SLC22A18	No	-	1	UBC
KRAS	ESR1	No	-	26	AKT1, MAPK1, TP53, SOS1, EGFR, CTGF, PRMT1, MAPK11, PPARD, PIK3CA, ERBB2, MAPK14, AKT2, HSP90AA1, JUN, NT5E, ABL1, SRC, VEGFA, SHC1, MGMT, MAPK3, IRS1, UBC, GRB2, CCND1
KRAS	PHB	No	-	4	UBC, RAF1, TP53, AKT1
KRAS	RAD51	No	-	3	IRS1, TP53, ABL1
KRAS	PIK3CA	Yes	activation, binding	37	BCL2L1, EGFR, RET, MAP2K2, TP53, SOS1, PIK3CG, TEK, VEGFA, ANGPT1, MAP2K1, PTK2, EPHA2, ERBB2, ERBB3, RAF1, SHC1, AKT2, KIT, HRAS, RPS6KB1, GRB2, AKT1, SRC, FYN, FRS2, YES1, NOTCH1, PTPN11, PIK3CB, MTOR, IRS2, EGF, IRS1, PIK3CD, CCND1, ERBB4
TP53	SLC22A18	No	-	2	UBC, RB1CC1
TP53	ESR1	Yes	activation, binding	109	POU4F2, ABL1, CAV1, TRIM24, HDAC9, PCNA, FOXO3, MAP3K1, NCOA3, ERBB2, RBBP5, MAPK14, BARD1, JUN, POU4F1, NR4A1, AKT1, PRDM2, EP400, NEDD8, MAPK3, HMGA1, SMARCA4, AR, EGFR, STK11, TWIST1, EZH2, MYB, ASH2L, STUB1, SP1, CARM1, KDM1A, PPARGC1A, TERT, TSC2, GAPDH, NR4A2, HSP90AA1, MAPK11, IGF1R, HDAC2, UBC, MSH2, MTA2, SMAD4, KAT5, FOS, NCOR1, PHB, NOS3, FOXM1, SUMO1, CCND1, KLF5, STAT5A, MTA1, SMAD3, FOXO1, BRCA1, SIRT1, HDAC1, SMAD2, MED1, PTEN, VEGFA, EP300, LEP, MGMT, NR0B2, WDR5, TADA3, MNAT1, HNF4A, MDM2, TBP, MAPK1, XPO1, SNAI2, CXCL12, CTBP1, MUC1, PIK3CA, CDK9, COPS5, CD82, COL18A1, CDKN1A, VDR, SIN3A, CTSD, CTGF, PARP1, PRMT1, MTA3, UBE2I, STAT3, HSPA8, NR3C1, DDX17, CREBBP, HSPA4, PAGR1, IL6, SP3, MYC, RELA, PPARG
TP53	PHB	Yes	activation, binding	12	RAF1, HDAC1, ANXA2, RNF2, RB1, NCOR1, ESR1, UBC, SMARCA4, AKT1, HIC1, YWHAZ
TP53	PALB2	No	-	3	BRCA1, BRCA2, RAD51
TP53	RAD51	Yes	activation, binding	29	PCNA, FOXM1, CDK4, PLK1, RPA3, H2AFX, RAD9A, EGR1, MSH2, RPA1, BRCA1, CDK2, BARD1, SUMO1, ABL1, MSH6, SUMO2, UBE2I, PMS2, BRCA2, POLI, WRN, CHEK1, TP53BP1, BLM, SMARCA4, POLH, UBE2A, MLH1
TP53	PIK3CA	Yes	activation, expression	42	BCL2L1, PTEN, MET, EPHB4, LYN, AGT, CREB1, EGFR, SP1, PRKCD, GSK3B, CCND1, PTK2, EPHA2, ERBB2, SMAD3, RAF1, NGFR, YWHAZ, HGF, AR, HRAS, EFNB1, NOTCH1, CDH1, SMAD2, AKT1, NTN1, VEGFA, NFKB1, STAT3, KRAS, NR3C1, PTPN11, BDNF, RELA, MTOR, SGK1, ESR1, MYC, IGF1R, ERBB4
SLC22A18	ESR1	No	-	1	UBC
SLC22A18	PHB	No	-	1	UBC
ESR1	PHB	Yes	binding	8	SMARCA2, SMARCA4, HDAC1, TP53, AKT1, UBC, E2F1, NCOR1
ESR1	PALB2	No	-	1	BRCA1
ESR1	RAD51	No	-	13	SMARCA2, FOXM1, SUMO1, MSH2, BARD1, TP53, CEBPB, ABL1, IRS1, PCNA, BRCA1, UBE2I, SMARCA4
ESR1	PIK3CA	Yes	activation, binding	44	AR, PELP1, PGR, GNG2, GNA11, GNA15, TP53, CCND3, SOS1, EGFR, GNAI1, SP1, INS, RHOA, THRB, ERBB2, SMAD3, SGK3, SHC1, GNB1, AKT2, THRA, RPS6KA3, GNA14, SMAD2, AKT1, SRC, VEGFA, GRB2, STAT3, NR3C1, IGF1R, RRAS2, IRS1, GNAI3, PIK3R1, PTEN, RAC3, IGF1, GNAQ, MYC, RELA, CCND1, BCAR1
PHB	RAD51	No	-	4	SMARCA2, TP53, SMARCA4, BRE
PHB	PIK3CA	No	-	5	TP53, RAF1, ESR1, AKT1, YWHAZ
PALB2	RAD51	Yes	binding	3	BRCA1, BRCA2, RAD51C
RAD51	PIK3CA	No	-	3	BCR, IRS1, TP53

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
ATM	BRIP1	No	-	1	BRCA1
ATM	FAM175A	No	-	1	BRCA1
ATM	NBN	Yes	MDC1-MRN-ATM-FANCD2 complex;ATM-NBS1 complex;BASC complex (BRCA1-associated genome surveillance complex)	13	ATM, FANCD2, RFC2, MSH2, MSH6, MDC1, BLM, MRE11A, RFC1, RFC4, RAD50, BRCA1, MLH1
ATM	BRCA1	Yes	BASC (Ab 81) complex (BRCA1-associated genome surveillance complex);BASC complex (BRCA1-associated genome surveillance complex)	11	ATM, NBN, MSH2, MRE11A, MSH6, RFC1, BLM, RAD50, RFC4, RFC2, MLH1
ATM	BRCA2	No	-	1	BRCA1
ATM	BARD1	No	-	6	NBN, MRE11A, RAD50, MSH6, BRCA1, MLH1
ATM	TP53	No	-	3	MSH6, BLM, MSH2
ATM	RAD51	No	-	4	MSH6, BRCA1, MSH2, BLM
BRIP1	FAM175A	No	-	1	BRCA1
BRIP1	NBN	No	-	1	BRCA1
BRIP1	BRCA1	Yes	BRCA1-BACH1 complex	0
BRIP1	BRCA2	No	-	1	BRCA1
BRIP1	BARD1	No	-	1	BRCA1
BRIP1	RAD51	No	-	1	BRCA1
XRCC3	RAD51	No	-	1	XRCC2
FAM175A	NBN	No	-	2	BRCA1, BARD1
FAM175A	BRCA1	Yes	BRCA1 A complex	2	UIMC1, BARD1
FAM175A	BRCA2	No	-	2	BRCA1, BARD1
FAM175A	BARD1	Yes	BRCA1 A complex	2	BRCA1, UIMC1
FAM175A	TP53	No	-	1	BARD1
FAM175A	RAD51	No	-	1	BRCA1
NBN	BRCA1	Yes	BRCA1-BARD1-BACH1-DNA damage complex II;BRCA1-RAD50-MRE11-NBS1 complex;BASC complex (BRCA1-associated genome surveillance complex)	15	ATM, TOPBP1, RFC2, BACH1, MLH1, BARD1, TRRAP, RFC1, MRE11A, BLM, RBBP8, RFC4, RAD50, MSH6, MSH2
NBN	BRCA2	No	-	2	BRCA1, BARD1
NBN	BARD1	Yes	BRCA1-BARD1-BACH1-DNA damage complex II	9	TOPBP1, BACH1, MRE11A, XRCC6, RBBP8, RAD50, MSH6, BRCA1, MLH1
NBN	TP53	No	-	5	MSH6, BARD1, BLM, XRCC6, MSH2
NBN	ESR1	No	-	1	TRRAP
NBN	RAD51	No	-	4	MSH6, BRCA1, MSH2, BLM
CDH1	BRCA1	No	-	1	SMAD3
CDH1	ESR1	No	-	2	SRC, BCAR1
BRCA1	BRCA2	Yes	BRCC complex;BRCA1-BARD1-BRCA2-DNA damage complex III	6	BRE, HDAC2, HDAC1, BARD1, BRCC3, RAD51
BRCA1	BARD1	Yes	BARD1-BRCA1-CSTF64 complex;BRCA1-BARD1-UbcH7c complex;HUIC complex;BRCA1-BARD1-POLR2A complex;BARD1-BRCA1-CSTF complex;BRCA1-BARD1-BRCA2-DNA damage complex III;BRCA1 B complex;BRCA1-BARD1-BACH1-DNA damage complex II;BRCA1 C complex;BRCA1-BARD1-UbcH5c complex;BRCA1-BARD1-BACH1-DNA damage complex I;BRCA1 A complex	17	NBN, TOPBP1, BRCA2, BACH1, MRE11A, UIMC1, UBE2L3, CSTF3, FAM175A, POLR2A, RBBP8, UBE2D3, RAD50, CSTF2, MSH6, MLH1, CSTF1
BRCA1	TP53	No	-	5	MSH6, BLM, BARD1, MSH2, RAD51
BRCA1	ESR1	No	-	3	TRRAP, HDAC2, KAT2A
BRCA1	RAD51	Yes	BRCC complex;BRCA1-RAD51 complex	6	BRE, BRCA2, MSH2, BLM, MSH6, BRCC3
BRCA2	BARD1	Yes	BRCA1-BARD1-BRCA2-DNA damage complex III	1	BRCA1
BRCA2	TP53	No	-	2	BARD1, RAD51
BRCA2	ESR1	No	-	1	HDAC2
BRCA2	RAD51	Yes	BRCC complex	3	BRCA1, BRE, BRCC3
BARD1	TP53	Yes	P53-BARD1-Ku70 complex	3	MSH6, XRCC6, TP53
BARD1	ESR1	No	-	1	TP53
BARD1	RAD51	No	-	4	BRCA1, BRCA2, MSH6, TP53
TP53	ESR1	Yes	Er-alpha-p53-hdm2 complex	3	SP1, TP53, MDM2
TP53	RAD51	Yes	MSH2/6-BLM-p53-RAD51 complex	4	MSH6, BLM, MSH2, TP53
ESR1	CASP8	No	-	1	CHUK
ESR1	RAD51	No	-	1	TP53
ESR1	PIK3CA	No	-	1	PIK3R1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
BRIP1	FAM175A	No	1	BRCA1
BRIP1	BRCA1	Yes	2	BRCA1, BRIP1
BRIP1	BARD1	No	1	BRCA1
FAM175A	BRCA1	Yes	2	FAM175A, BRCA1
FAM175A	BARD1	No	1	BRCA1
BRCA1	BARD1	Yes	2	BRCA1, BARD1
BRCA2	PALB2	Yes	2	PALB2, BRCA2
BRCA2	RAD51	Yes	2	BRCA2, RAD51
PALB2	RAD51	No	1	BRCA2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

Gene1	Gene2	Direct interaction	More information
CHEK2	TP53	yes, they interact	TP53 is phosphorylated on Ser-20 by CHEK2 in response to DNA damage. [UniProt]

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Pathways in cancer	hsa05200	3.98	8	KRAS, BRCA2, CASP8, PIK3CA, CDH1, TP53, AKT1, RAD51
Pancreatic cancer	hsa05212	6.56	6	BRCA2, TP53, KRAS, PIK3CA, AKT1, RAD51
HTLV-I infection	hsa05166	4.59	6	ATM, TP53, KRAS, PIK3CA, AKT1, CHEK2
Melanoma	hsa05218	6.56	5	TP53, KRAS, AKT1, PIK3CA, CDH1
Fanconi anemia pathway	hsa03460	7.01	5	BRCA2, BRCA1, BRIP1, PALB2, RAD51
Proteoglycans in cancer	hsa05205	5.02	5	TP53, ESR1, KRAS, AKT1, PIK3CA
Endometrial cancer	hsa05213	6.81	5	TP53, KRAS, AKT1, CDH1, PIK3CA
MicroRNAs in cancer	hsa05206	5.38	5	ATM, BRCA1, KRAS, TP53, PIK3CA
p53 signaling pathway	hsa04115	6.56	5	ATM, CHEK2, PPM1D, CASP8, TP53
Homologous recombination	hsa03440	7.91	5	NBN, RAD54L, BRCA2, RAD51, XRCC3
Apoptosis	hsa04210	6.23	5	ATM, CASP8, TP53, AKT1, PIK3CA
Thyroid hormone signaling pathway	hsa04919	5.82	5	TP53, KRAS, ESR1, AKT1, PIK3CA
Hepatitis B	hsa05161	5.52	5	KRAS, CASP8, TP53, AKT1, PIK3CA
PI3K-Akt signaling pathway	hsa04151	4.21	5	TP53, BRCA1, KRAS, AKT1, PIK3CA
Colorectal cancer	hsa05210	6.52	4	KRAS, TP53, AKT1, PIK3CA
Estrogen signaling pathway	hsa04915	6.11	4	ESR1, KRAS, AKT1, PIK3CA
Glioma	hsa05214	6.66	4	TP53, AKT1, KRAS, PIK3CA
Prostate cancer	hsa05215	6.11	4	KRAS, TP53, AKT1, PIK3CA
Rap1 signaling pathway	hsa04015	4.97	4	KRAS, AKT1, PIK3CA, CDH1
Neurotrophin signaling pathway	hsa04722	5.78	4	KRAS, TP53, AKT1, PIK3CA
Central carbon metabolism in cancer	hsa05230	6.7	4	TP53, KRAS, AKT1, PIK3CA
Viral carcinogenesis	hsa05203	5.08	4	KRAS, CASP8, TP53, PIK3CA
FoxO signaling pathway	hsa04068	5.63	4	ATM, AKT1, KRAS, PIK3CA
Chronic myeloid leukemia	hsa05220	6.48	4	TP53, KRAS, AKT1, PIK3CA
Non-small cell lung cancer	hsa05223	6.88	4	TP53, AKT1, KRAS, PIK3CA
Hepatitis C	hsa05160	5.68	4	TP53, KRAS, AKT1, PIK3CA
Prolactin signaling pathway	hsa04917	6.6	4	KRAS, ESR1, AKT1, PIK3CA
Signaling pathways regulating pluripotency of stem cells	hsa04550	5.6	3	AKT1, KRAS, PIK3CA
Bladder cancer	hsa05219	7.38	3	KRAS, TP53, CDH1
Progesterone-mediated oocyte maturation	hsa04914	6.18	3	AKT1, KRAS, PIK3CA
Renal cell carcinoma	hsa05211	6.6	3	AKT1, KRAS, PIK3CA
Thyroid cancer	hsa05216	7.48	3	KRAS, TP53, CDH1
Cholinergic synapse	hsa04725	5.88	3	KRAS, AKT1, PIK3CA
Choline metabolism in cancer	hsa05231	6.09	3	KRAS, AKT1, PIK3CA
Chemokine signaling pathway	hsa04062	5.19	3	KRAS, AKT1, PIK3CA
Chagas disease (American trypanosomiasis)	hsa05142	5.99	3	AKT1, CASP8, PIK3CA
Epstein-Barr virus infection	hsa05169	4.97	3	AKT1, TP53, PIK3CA
Toxoplasmosis	hsa05145	5.71	3	CASP8, AKT1, PIK3CA
Measles	hsa05162	5.6	3	TP53, AKT1, PIK3CA
VEGF signaling pathway	hsa04370	6.77	3	KRAS, AKT1, PIK3CA
Cell cycle	hsa04110	5.68	3	ATM, CHEK2, TP53
Toll-like receptor signaling pathway	hsa04620	6.0	3	CASP8, AKT1, PIK3CA
T cell receptor signaling pathway	hsa04660	6.01	3	KRAS, AKT1, PIK3CA
Insulin signaling pathway	hsa04910	5.55	3	KRAS, PIK3CA, AKT1
Ras signaling pathway	hsa04014	4.9	3	KRAS, PIK3CA, AKT1
Fc epsilon RI signaling pathway	hsa04664	6.6	3	KRAS, AKT1, PIK3CA
Small cell lung cancer	hsa05222	6.17	3	TP53, AKT1, PIK3CA
Acute myeloid leukemia	hsa05221	6.74	3	KRAS, PIK3CA, AKT1
MAPK signaling pathway	hsa04010	4.63	3	KRAS, TP53, AKT1
TNF signaling pathway	hsa04668	5.96	3	CASP8, AKT1, PIK3CA
Non-alcoholic fatty liver disease (NAFLD)	hsa04932	5.51	3	CASP8, AKT1, PIK3CA
B cell receptor signaling pathway	hsa04662	6.52	3	AKT1, KRAS, PIK3CA
ErbB signaling pathway	hsa04012	6.15	3	KRAS, PIK3CA, AKT1
Platelet activation	hsa04611	5.66	2	PIK3CA, AKT1
cGMP-PKG signaling pathway	hsa04022	5.32	2	AKT1, PIK3CA
Natural killer cell mediated cytotoxicity	hsa04650	5.53	2	KRAS, PIK3CA
cAMP signaling pathway	hsa04024	5.05	2	PIK3CA, AKT1
Jak-STAT signaling pathway	hsa04630	5.44	2	AKT1, PIK3CA
Tight junction	hsa04530	5.53	2	KRAS, AKT1
Focal adhesion	hsa04510	4.92	2	PIK3CA, AKT1
Osteoclast differentiation	hsa04380	5.64	2	PIK3CA, AKT1
HIF-1 signaling pathway	hsa04066	5.9	2	AKT1, PIK3CA
Oxytocin signaling pathway	hsa04921	5.4	2	KRAS, PIK3CA
Aldosterone-regulated sodium reabsorption	hsa04960	7.41	2	KRAS, PIK3CA
Herpes simplex infection	hsa05168	5.08	2	CASP8, TP53
Influenza A	hsa05164	5.21	2	AKT1, PIK3CA
Bacterial invasion of epithelial cells	hsa05100	6.34	2	PIK3CA, CDH1
Transcriptional misregulation in cancer	hsa05202	5.21	2	ATM, TP53
Fc gamma R-mediated phagocytosis	hsa04666	6.21	2	PIK3CA, AKT1
AMPK signaling pathway	hsa04152	5.8	2	AKT1, PIK3CA
mTOR signaling pathway	hsa04150	6.72	2	AKT1, PIK3CA
Regulation of actin cytoskeleton	hsa04810	4.9	2	KRAS, PIK3CA
Carbohydrate digestion and absorption	hsa04973	7.28	2	PIK3CA, AKT1
Tuberculosis	hsa05152	5.17	2	CASP8, AKT1
Huntington's disease	hsa05016	5.17	2	CASP8, TP53
Adrenergic signaling in cardiomyocytes	hsa04261	5.44	2	AKT1, PIK3CA

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Salmonella infection (hsa05132)	NEW	6.29	0.002	ESR1, CASP8, CDH1, TP53, AKT1, PIK3CA
Melanoma (hsa05218)	-	6.56	0.0	ESR1, TP53, CDH1, KRAS, AKT1, PIK3CA
Bladder cancer (hsa05219)	-	7.38	0.003	TP53, KRAS, AKT1, CDH1
Progesterone-mediated oocyte maturation (hsa04914)	-	6.18	0.0	KRAS, ESR1, CDH1, TP53, AKT1, PIK3CA, BRCA1
Pancreatic cancer (hsa05212)	-	6.56	0.0	KRAS, BRCA2, ESR1, TP53, PIK3CA, AKT1, RAD51
Natural killer cell mediated cytotoxicity (hsa04650)	-	5.53	0.009	ESR1, CASP8, KRAS, TP53, AKT1, PIK3CA
Colorectal cancer (hsa05210)	-	6.52	0.002	TP53, KRAS, ESR1, AKT1, PIK3CA
Estrogen signaling pathway (hsa04915)	-	6.11	0.024	ATM, ESR1, KRAS, AKT1, PIK3CA
Thyroid cancer (hsa05216)	-	7.48	0.002	TP53, ESR1, KRAS, CDH1
Signaling pathways regulating pluripotency of stem cells (hsa04550)	-	5.6	0.0	KRAS, ESR1, CDH1, TP53, AKT1, PIK3CA, BRCA1, CHEK2
Glioma (hsa05214)	-	6.66	0.005	TP53, KRAS, ESR1, AKT1, PIK3CA
Prostate cancer (hsa05215)	-	6.11	0.011	TP53, KRAS, ESR1, AKT1, PIK3CA
Lipid metabolism	NEW	4.16	0.036	ATM, KRAS, AKT1, CASP8, BARD1, TP53, PIK3CA, ESR1, BRCA1
Excretory system	NEW	5.45	0.027	ATM, ESR1, KRAS, TP53, AKT1, PIK3CA
Central carbon metabolism in cancer (hsa05230)	-	6.7	0.001	TP53, KRAS, AKT1, PIK3CA, CDH1
Choline metabolism in cancer (hsa05231)	-	6.09	0.042	ATM, TP53, KRAS, AKT1, PIK3CA
FoxO signaling pathway (hsa04068)	-	5.63	0.0	ATM, KRAS, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1
Chemokine signaling pathway (hsa04062)	-	5.19	0.007	ATM, KRAS, ESR1, CDH1, TP53, AKT1, PIK3CA
Thyroid hormone signaling pathway (hsa04919)	-	5.82	0.003	ATM, KRAS, ESR1, TP53, PIK3CA, AKT1, BRCA1
Endometrial cancer (hsa05213)	-	6.81	0.0	ESR1, TP53, CDH1, KRAS, AKT1, PIK3CA
Inflammatory mediator regulation of TRP channels (hsa04750)	NEW	6.07	0.041	ATM, ESR1, TP53, AKT1, PIK3CA
Chagas disease (American trypanosomiasis) (hsa05142)	-	5.99	0.003	ATM, ESR1, CASP8, TP53, PIK3CA, AKT1
Replication and repair	NEW	5.41	0.0	ATM, NBN, BRCA2, XRCC3, PALB2, TP53, ESR1, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
Amoebiasis (hsa05146)	NEW	5.82	0.01	ATM, CASP8, CDH1, RB1CC1, PIK3CA, AKT1
Infectious diseases: Parasitic	NEW	4.46	0.015	ATM, KRAS, ESR1, CASP8, TP53, CDH1, RB1CC1, PIK3CA, AKT1
Toxoplasmosis (hsa05145)	-	5.71	0.01	ESR1, CASP8, KRAS, TP53, AKT1, PIK3CA
Herpes simplex infection (hsa05168)	-	5.08	0.0	ATM, KRAS, ESR1, CASP8, PPM1D, TP53, CDH1, AKT1, CHEK2
HTLV-I infection (hsa05166)	-	4.59	0.016	ATM, KRAS, BRCA2, AKT1, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2
Hepatitis C (hsa05160)	-	5.68	0.001	KRAS, ESR1, PPM1D, CDH1, TP53, AKT1, PIK3CA
Hepatitis B (hsa05161)	-	5.52	0.008	KRAS, ESR1, CASP8, CDH1, TP53, AKT1, PIK3CA
Measles (hsa05162)	-	5.6	0.001	ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1, BRCA1
Apoptosis (hsa04210)	-	6.23	0.001	ATM, CASP8, TP53, AKT1, PIK3CA
Cancers: Overview	NEW	2.72	0.002	ATM, NBN, KRAS, BRCA2, AKT1, CASP8, PPM1D, BARD1, TP53, PHB, CDH1, PIK3CA, ESR1, BRCA1, BRIP1, CHEK2, RAD51
Cancers: Specific types	NEW	4.1	0.013	NBN, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, RAD51
Proteoglycans in cancer (hsa05205)	-	5.02	0.04	KRAS, ESR1, CDH1, TP53, AKT1, PIK3CA, BRCA1
Cell cycle (hsa04110)	-	5.68	0.0	ATM, BARD1, CDH1, TP53, ESR1, BRCA1, CHEK2
MicroRNAs in cancer (hsa05206)	-	5.38	0.013	ATM, KRAS, ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1
Toll-like receptor signaling pathway (hsa04620)	-	6.0	0.029	CASP8, ESR1, TP53, AKT1, PIK3CA
Pathways in cancer (hsa05200)	-	3.98	0.002	ATM, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, RAD51
Oocyte meiosis (hsa04114)	NEW	5.91	0.002	ATM, ESR1, PPM1D, TP53, AKT1, BRCA1
p53 signaling pathway (hsa04115)	-	6.56	0.0	ATM, CASP8, PPM1D, TP53, CHEK2, BRCA1
T cell receptor signaling pathway (hsa04660)	-	6.01	0.031	KRAS, CASP8, AKT1, ESR1, PIK3CA
Homologous recombination (hsa03440)	-	7.91	0.0	NBN, BRCA2, XRCC3, CHEK2, RAD54L, RAD51
Insulin signaling pathway (hsa04910)	-	5.55	0.028	ESR1, KRAS, TP53, AKT1, PIK3CA, BRCA1
Transport and catabolism	NEW	3.49	0.016	ATM, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, CHEK2, TSG101
Non-small cell lung cancer (hsa05223)	-	6.88	0.002	AKT1, TP53, ESR1, KRAS, PIK3CA
Prolactin signaling pathway (hsa04917)	-	6.6	0.005	TP53, KRAS, ESR1, AKT1, PIK3CA
Acute myeloid leukemia (hsa05221)	-	6.74	0.027	KRAS, ESR1, AKT1, PIK3CA
Chronic myeloid leukemia (hsa05220)	-	6.48	0.0	ESR1, TP53, CDH1, KRAS, AKT1, PIK3CA
Viral carcinogenesis (hsa05203)	-	5.08	0.0	ATM, PHB, KRAS, AKT1, CASP8, TP53, PIK3CA, ESR1, BRCA1
Fanconi anemia pathway (hsa03460)	-	7.01	0.0	BRCA2, PALB2, BRCA1, BRIP1, CHEK2, RAD51
Type II diabetes mellitus (hsa04930)	NEW	7.12	0.018	ESR1, TP53, AKT1, PIK3CA
Cell growth and death	NEW	4.41	0.0	ATM, AKT1, CASP8, PPM1D, BARD1, PIK3CA, CDH1, TP53, ESR1, BRCA1, CHEK2
Genetic Information Processing	NEW	2.48	0.0	ATM, NBN, XRCC3, BRCA2, AKT1, PPM1D, PALB2, BARD1, TP53, PHB, CDH1, RB1CC1, PIK3CA, ESR1, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
MAPK signaling pathway (hsa04010)	-	4.63	0.016	ATM, KRAS, ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1
NOD-like receptor signaling pathway (hsa04621)	NEW	6.88	0.041	TP53, CASP8, AKT1, TSG101
Alcoholism (hsa05034)	NEW	5.59	0.02	ATM, NBN, ESR1, KRAS, PIK3CA, AKT1
Tuberculosis (hsa05152)	-	5.17	0.024	KRAS, ESR1, CASP8, TP53, PIK3CA, AKT1, CHEK2
Fc epsilon RI signaling pathway (hsa04664)	-	6.6	0.036	TP53, KRAS, AKT1, PIK3CA

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Cell Cycle	R-HSA-1640170	3.89	9	ATM, NBN, BRCA2, BARD1, TP53, FAM175A, BRCA1, CHEK2, RAD51
Signal Transduction	R-HSA-162582	1.78	8	PHB, KRAS, ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1
Cell Cycle Checkpoints	R-HSA-69620	5.64	7	ATM, NBN, BARD1, TP53, FAM175A, BRCA1, CHEK2
DNA Repair	R-HSA-73894	5.8	7	ATM, NBN, BRCA2, PALB2, BRCA1, BRIP1, RAD51
G2/M Checkpoints	R-HSA-69481	6.46	6	ATM, NBN, BARD1, FAM175A, BRCA1, CHEK2
Homologous recombination repair of replication-independent double-strand breaks	R-HSA-73951	8.98	6	ATM, NBN, BRCA2, BRCA1, BRIP1, RAD51
G2/M DNA damage checkpoint	R-HSA-69473	7.15	6	ATM, NBN, BARD1, FAM175A, BRCA1, CHEK2
Immune System	R-HSA-168256	2.37	6	PHB, CASP8, KRAS, CDH1, AKT1, PIK3CA
Homologous Recombination Repair	R-HSA-73888	8.98	6	ATM, NBN, BRCA2, BRCA1, BRIP1, RAD51
Double-Strand Break Repair	R-HSA-73890	8.46	6	ATM, NBN, BRCA2, BRCA1, BRIP1, RAD51
Meiosis	R-HSA-1500620	6.59	5	ATM, NBN, BRCA1, BRCA2, RAD51
Innate Immune System	R-HSA-168249	3.17	5	PHB, CASP8, KRAS, AKT1, PIK3CA
Meiotic recombination	R-HSA-912446	7.25	5	NBN, ATM, BRCA1, BRCA2, RAD51
Signaling by ERBB4	R-HSA-1236394	4.7	5	PHB, KRAS, AKT1, ESR1, PIK3CA
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85	4	PHB, KRAS, PIK3CA, AKT1
Programmed Cell Death	R-HSA-5357801	5.65	4	TP53, CASP8, AKT1, CDH1
IGF1R signaling cascade	R-HSA-2428924	4.85	4	PHB, AKT1, PIK3CA, KRAS
Downstream signal transduction	R-HSA-186763	4.65	4	PHB, AKT1, KRAS, PIK3CA
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85	4	PHB, AKT1, KRAS, PIK3CA
Signaling by Insulin receptor	R-HSA-74752	4.73	4	PHB, AKT1, KRAS, PIK3CA
Adaptive Immune System	R-HSA-1280218	3.19	4	KRAS, AKT1, PIK3CA, CDH1
Disease	R-HSA-1643685	3.33	4	KRAS, AKT1, PIK3CA, TSG101
Insulin receptor signalling cascade	R-HSA-74751	4.85	4	PHB, KRAS, PIK3CA, AKT1
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71	4	PHB, AKT1, PIK3CA, KRAS
Signalling by NGF	R-HSA-166520	4.23	4	PHB, AKT1, KRAS, PIK3CA
Signaling by VEGF	R-HSA-194138	4.66	4	PHB, KRAS, PIK3CA, AKT1
Cellular responses to stress	R-HSA-2262752	4.56	4	ATM, NBN, RB1CC1, TP53
IRS-mediated signalling	R-HSA-112399	4.87	4	PHB, KRAS, PIK3CA, AKT1
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71	4	PHB, KRAS, AKT1, PIK3CA
Signaling by FGFR4	R-HSA-5654743	4.69	4	PHB, AKT1, KRAS, PIK3CA
Signaling by FGFR3	R-HSA-5654741	4.69	4	PHB, KRAS, AKT1, PIK3CA
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	4	PHB, AKT1, PIK3CA, KRAS
Signaling by FGFR	R-HSA-190236	4.67	4	PHB, AKT1, KRAS, PIK3CA
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03	4	PHB, KRAS, PIK3CA, AKT1
Signaling by SCF-KIT	R-HSA-1433557	4.73	4	PHB, KRAS, AKT1, PIK3CA
Signaling by PDGF	R-HSA-186797	4.53	4	PHB, KRAS, AKT1, PIK3CA
DAP12 signaling	R-HSA-2424491	4.64	4	PHB, AKT1, KRAS, PIK3CA
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71	4	PHB, KRAS, PIK3CA, AKT1
Signaling by EGFR	R-HSA-177929	4.59	4	PHB, KRAS, PIK3CA, AKT1
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51	4	PHB, KRAS, AKT1, PIK3CA
Fanconi Anemia pathway	R-HSA-419524	8.4	4	ATM, BRCA1, BRCA2, PALB2
Signaling by GPCR	R-HSA-372790	2.68	4	PHB, KRAS, AKT1, PIK3CA
Signaling by FGFR2	R-HSA-5654738	4.68	4	PHB, AKT1, KRAS, PIK3CA
Signaling by FGFR1	R-HSA-5654736	4.69	4	PHB, KRAS, AKT1, PIK3CA
DAP12 interactions	R-HSA-2172127	4.56	4	PHB, KRAS, AKT1, PIK3CA
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71	4	PHB, AKT1, KRAS, PIK3CA
Signaling by ERBB2	R-HSA-1227986	4.66	4	PHB, KRAS, AKT1, PIK3CA
Metabolism	R-HSA-1430728	2.34	4	AKT1, BRIP1, PIK3CA, HMMR
Hemostasis	R-HSA-109582	3.98	4	TP53, KRAS, AKT1, PIK3CA
Apoptosis	R-HSA-109581	5.68	4	TP53, CASP8, AKT1, CDH1
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.59	3	AKT1, KRAS, PIK3CA
Diseases of signal transduction	R-HSA-5663202	4.89	3	KRAS, PIK3CA, AKT1
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	7.15	3	ATM, NBN, TP53
Cellular Senescence	R-HSA-2559583	5.7	3	ATM, NBN, TP53
Signaling by Interleukins	R-HSA-449147	4.71	3	PHB, KRAS, PIK3CA
Generic Transcription Pathway	R-HSA-212436	3.86	3	ESR1, TP53, AKT1
Gene Expression	R-HSA-74160	2.72	3	ESR1, TP53, AKT1
Interleukin receptor SHC signaling	R-HSA-912526	5.09	3	PHB, KRAS, PIK3CA
Interleukin-2 signaling	R-HSA-451927	5.05	3	PHB, KRAS, PIK3CA
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.62	3	KRAS, AKT1, PIK3CA
ATM mediated response to DNA double-strand break	R-HSA-83542	10.66	3	ATM, NBN, BRCA1
G1/S DNA Damage Checkpoints	R-HSA-69615	7.08	3	ATM, CHEK2, TP53
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	3	PHB, KRAS, PIK3CA
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99	3	PHB, KRAS, PIK3CA
Recruitment of repair and signaling proteins to double-strand breaks	R-HSA-75154	9.98	3	ATM, NBN, BRCA1
ATM mediated phosphorylation of repair proteins	R-HSA-75148	10.66	3	ATM, NBN, BRCA1
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26	3	PHB, KRAS, PIK3CA
Intrinsic Pathway for Apoptosis	R-HSA-109606	7.73	3	CASP8, TP53, AKT1
Homologous DNA Pairing and Strand Exchange	R-HSA-76010	10.18	3	BRCA2, BRIP1, RAD51
Developmental Biology	R-HSA-1266738	3.48	3	PHB, KRAS, AKT1
PI-3K cascade:FGFR4	R-HSA-5654720	6.37	2	PIK3CA, AKT1
Transcriptional Regulation by TP53	R-HSA-3700989	6.73	2	TP53, AKT1
FCERI mediated MAPK activation	R-HSA-2871796	4.32	2	PHB, KRAS
NCAM signaling for neurite out-growth	R-HSA-375165	4.9	2	PHB, KRAS
PI3K/AKT activation	R-HSA-198203	6.32	2	AKT1, PIK3CA
Signaling by FGFR3 in disease	R-HSA-5655332	8.52	2	KRAS, PIK3CA
GPVI-mediated activation cascade	R-HSA-114604	7.18	2	AKT1, PIK3CA
Signaling by Leptin	R-HSA-2586552	5.1	2	PHB, KRAS
Frs2-mediated activation	R-HSA-170968	5.12	2	PHB, KRAS
PI3K events in ERBB2 signaling	R-HSA-1963642	6.37	2	PIK3CA, AKT1
Cell surface interactions at the vascular wall	R-HSA-202733	6.32	2	KRAS, PIK3CA
Cell-Cell communication	R-HSA-1500931	5.87	2	PIK3CA, CDH1
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	4.95	2	AKT1, PIK3CA
GAB1 signalosome	R-HSA-180292	6.31	2	AKT1, PIK3CA
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14	2	PHB, KRAS
RAF activation	R-HSA-5673000	8.34	2	PHB, KRAS
RAF/MAP kinase cascade	R-HSA-5673001	5.15	2	PHB, KRAS
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	8.73	2	KRAS, PIK3CA
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	7.28	2	ATM, CHEK2
MAPK family signaling cascades	R-HSA-5683057	4.89	2	PHB, KRAS
PIP3 activates AKT signaling	R-HSA-1257604	6.37	2	AKT1, PIK3CA
PI3K Cascade	R-HSA-109704	6.68	2	AKT1, PIK3CA
Apoptotic cleavage of cellular proteins	R-HSA-111465	7.73	2	CASP8, CDH1
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11	2	PHB, KRAS
PI-3K cascade:FGFR1	R-HSA-5654689	6.37	2	PIK3CA, AKT1
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-76003	10.4	2	BRCA2, RAD51
SHC1 events in EGFR signaling	R-HSA-180336	5.15	2	PHB, KRAS
p53-Dependent G1 DNA Damage Response	R-HSA-69563	7.15	2	ATM, TP53
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14	2	PHB, KRAS
SOS-mediated signalling	R-HSA-112412	5.15	2	PHB, KRAS
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14	2	PHB, KRAS
Constitutive Signaling by EGFRvIII	R-HSA-5637810	9.08	2	KRAS, PIK3CA
CD28 co-stimulation	R-HSA-389356	7.98	2	PIK3CA, AKT1
Signaling by EGFRvIII in Cancer	R-HSA-5637812	9.08	2	KRAS, PIK3CA
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	7.15	2	ATM, TP53
Signaling by EGFR in Cancer	R-HSA-1643713	8.73	2	KRAS, PIK3CA
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	7.31	2	ATM, TP53
Signaling by FGFR in disease	R-HSA-1226099	7.49	2	KRAS, PIK3CA
C-type lectin receptors (CLRs)	R-HSA-5621481	6.06	2	KRAS, CASP8
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.56	2	PIK3CA, AKT1
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15	2	PHB, KRAS
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.59	2	AKT1, PIK3CA
Signaling by FGFR1 in disease	R-HSA-5655302	7.81	2	KRAS, PIK3CA
Membrane Trafficking	R-HSA-199991	5.26	2	AKT1, TSG101
Activation of BH3-only proteins	R-HSA-114452	8.34	2	TP53, AKT1
Signalling to RAS	R-HSA-167044	5.08	2	PHB, KRAS
GPCR downstream signaling	R-HSA-388396	3.07	2	PIK3CA, AKT1
PI-3K cascade:FGFR2	R-HSA-5654695	6.37	2	PIK3CA, AKT1
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	8.73	2	KRAS, PIK3CA
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.73	2	TP53, AKT1
Vesicle-mediated transport	R-HSA-5653656	4.33	2	AKT1, TSG101
Prolonged ERK activation events	R-HSA-169893	5.11	2	PHB, KRAS
Apoptotic execution phase	R-HSA-75153	7.28	2	CASP8, CDH1
Signalling to ERKs	R-HSA-187687	5.04	2	PHB, KRAS
Stabilization of p53	R-HSA-69541	7.28	2	ATM, TP53
GRB2 events in EGFR signaling	R-HSA-179812	5.15	2	PHB, KRAS
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15	2	PHB, KRAS
PI3K events in ERBB4 signaling	R-HSA-1250342	6.37	2	AKT1, PIK3CA
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.4	2	AKT1, PIK3CA
G-protein beta:gamma signalling	R-HSA-397795	7.31	2	AKT1, PIK3CA
ARMS-mediated activation	R-HSA-170984	5.12	2	PHB, KRAS
PI-3K cascade:FGFR3	R-HSA-5654710	6.37	2	PIK3CA, AKT1
Signaling by FGFR4 in disease	R-HSA-5655291	9.52	2	KRAS, PIK3CA
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14	2	PHB, KRAS
Tie2 Signaling	R-HSA-210993	8.81	2	KRAS, PIK3CA
p53-Independent DNA Damage Response	R-HSA-69610	7.28	2	ATM, CHEK2
p53-Independent G1/S DNA damage checkpoint	R-HSA-69613	7.28	2	ATM, CHEK2
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15	2	PHB, KRAS
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12	2	PHB, KRAS
Axon guidance	R-HSA-422475	3.93	2	PHB, KRAS
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07	2	PHB, KRAS
Signaling by FGFR2 in disease	R-HSA-5655253	8.23	2	KRAS, PIK3CA
Platelet activation, signaling and aggregation	R-HSA-76002	5.15	2	PIK3CA, AKT1
Costimulation by the CD28 family	R-HSA-388841	6.56	2	PIK3CA, AKT1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Signaling by FGFR3 in disease (R-HSA-5655332)	-	8.52	0.018	KRAS, PIK3CA, CDH1
Cellular responses to stress (R-HSA-2262752)	-	4.56	0.023	ATM, NBN, CASP8, TP53, RB1CC1, CDH1, AKT1, BRCA1, CHEK2
Recruitment of repair and signaling proteins to double-strand breaks (R-HSA-75154)	-	9.98	0.0	ATM, NBN, BRCA1
Cell Cycle (R-HSA-1640170)	-	3.89	0.0	ATM, NBN, BRCA2, AKT1, PPM1D, BARD1, TP53, FAM175A, ESR1, BRCA1, CHEK2, RAD51
Homologous recombination repair of replication-independent double-strand breaks (R-HSA-73951)	-	8.98	0.0	ATM, NBN, BRCA2, BRCA1, BRIP1, RAD51
RAF activation (R-HSA-5673000)	-	8.34	0.04	PHB, KRAS, AKT1
G2/M DNA damage checkpoint (R-HSA-69473)	-	7.15	0.0	ATM, NBN, BARD1, FAM175A, BRCA1, CHEK2
Presynaptic phase of homologous DNA pairing and strand exchange (R-HSA-76003)	-	10.4	0.03	BRCA2, RAD51
Phospholipid metabolism (R-HSA-1483257)	NEW	5.83	0.002	ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1, BRCA1
ATM mediated response to DNA double-strand break (R-HSA-83542)	-	10.66	0.0	ATM, NBN, BRCA1
Cell Cycle Checkpoints (R-HSA-69620)	-	5.64	0.0	ATM, NBN, BARD1, TP53, FAM175A, BRCA1, CHEK2, RAD51
Homologous Recombination Repair (R-HSA-73888)	-	8.98	0.0	ATM, NBN, BRCA2, BRCA1, BRIP1, RAD51
FGFR1 mutant receptor activation (R-HSA-1839124)	NEW	8.12	0.005	ESR1, AKT1, PIK3CA, CDH1
Signaling by FGFR in disease (R-HSA-1226099)	-	7.49	0.001	AKT1, KRAS, ESR1, PIK3CA, CDH1
MAP kinase activation in TLR cascade (R-HSA-450294)	NEW	7.28	0.022	ATM, CASP8, TP53, AKT1
Signaling by FGFR1 in disease (R-HSA-5655302)	-	7.81	0.0	KRAS, ESR1, AKT1, CDH1, PIK3CA
NCAM signaling for neurite out-growth (R-HSA-375165)	-	4.9	0.031	PHB, KRAS, ESR1, CDH1, RB1CC1, TP53, AKT1, PIK3CA
ATM mediated phosphorylation of repair proteins (R-HSA-75148)	-	10.66	0.0	ATM, NBN, BRCA1
Fanconi Anemia pathway (R-HSA-419524)	-	8.4	0.0	ATM, BRCA1, BRCA2, PALB2
G2/M Checkpoints (R-HSA-69481)	-	6.46	0.0	ATM, NBN, BARD1, TP53, FAM175A, BRCA1, CHEK2
RHO GTPase Effectors (R-HSA-195258)	NEW	4.94	0.003	KRAS, ESR1, PPM1D, RAD51, TP53, CDH1, PIK3CA, AKT1, TSG101
Signaling by FGFR2 in disease (R-HSA-5655253)	-	8.23	0.034	KRAS, PIK3CA, CDH1
Homologous DNA Pairing and Strand Exchange (R-HSA-76010)	-	10.18	0.0	BRCA2, BRIP1, RAD51
Meiotic recombination (R-HSA-912446)	-	7.25	0.0	ATM, NBN, BRCA2, TP53, BRCA1, RAD51
Meiosis (R-HSA-1500620)	-	6.59	0.001	ATM, NBN, BRCA2, TP53, BRCA1, RAD51
DNA Repair (R-HSA-73894)	-	5.8	0.0	ATM, NBN, BRCA2, PALB2, TP53, ESR1, BRCA1, BRIP1, RAD51
Intrinsic Pathway for Apoptosis (R-HSA-109606)	-	7.73	0.039	CASP8, TP53, AKT1
Double-Strand Break Repair (R-HSA-73890)	-	8.46	0.0	ATM, NBN, BRCA2, BRCA1, BRIP1, RAD51

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	26	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, SLC22A18, BARD1, CDH1, AKT1, BRIP1, HMMR, BRCA2, NQO2, RAD51, ESR1, CHEK2, TSG101
protein binding (GO:0005515)	0.46	26	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, SLC22A18, BARD1, CDH1, AKT1, BRIP1, HMMR, BRCA2, NQO2, RAD51, ESR1, CHEK2, TSG101
organic cyclic compound binding (GO:0097159)	1.05	18	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, PALB2, BARD1, TP53, RAD51, ESR1, PIK3CA, NBN, CHEK2, RAD54L, BRIP1, BRCA1, TSG101
heterocyclic compound binding (GO:1901363)	1.06	18	ATM, PHB, XRCC3, KRAS, BRCA2, AKT1, PALB2, BARD1, TP53, RAD51, ESR1, PIK3CA, NBN, CHEK2, RAD54L, BRIP1, BRCA1, TSG101
catalytic activity (GO:0003824)	1.05	16	ATM, NBN, KRAS, BRCA2, XRCC3, CASP8, PPM1D, BARD1, PIK3CA, NQO2, AKT1, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
enzyme binding (GO:0019899)	2.27	14	PHB, SLC22A18, BRCA2, AKT1, CASP8, BARD1, PPM1D, TP53, RB1CC1, RAD51, ESR1, BRCA1, CHEK2, TSG101
nucleic acid binding (GO:0003676)	1.44	14	PHB, ATM, BRCA2, ESR1, PALB2, BARD1, TP53, RAD51, XRCC3, NBN, BRCA1, BRIP1, RAD54L, TSG101
DNA binding (GO:0003677)	1.92	13	PHB, ATM, BRCA2, XRCC3, PALB2, TP53, RAD51, ESR1, NBN, RAD54L, BRIP1, BRCA1, TSG101
carbohydrate derivative binding (GO:0097367)	2.03	12	ATM, KRAS, XRCC3, RAD51, TP53, CDH1, PIK3CA, AKT1, RAD54L, BRIP1, CHEK2, HMMR
ion binding (GO:0043167)	1.36	11	KRAS, AKT1, PPM1D, BARD1, TP53, CDH1, NQO2, ESR1, BRCA1, BRIP1, CHEK2
cation binding (GO:0043169)	1.4	10	KRAS, PPM1D, BARD1, TP53, CDH1, NQO2, ESR1, BRCA1, BRIP1, CHEK2
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	10	ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
nucleotide binding (GO:0000166)	1.96	10	ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
small molecule binding (GO:0036094)	1.89	10	ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
ribonucleotide binding (GO:0032553)	2.19	10	ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
purine nucleoside binding (GO:0001883)	2.22	10	ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
ribonucleoside binding (GO:0032549)	2.22	10	ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
purine ribonucleotide binding (GO:0032555)	2.2	10	ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
purine nucleotide binding (GO:0017076)	2.19	10	ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
metal ion binding (GO:0046872)	1.41	10	KRAS, PPM1D, BARD1, TP53, CDH1, NQO2, ESR1, BRCA1, BRIP1, CHEK2
purine ribonucleoside binding (GO:0032550)	2.22	10	ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
nucleoside phosphate binding (GO:1901265)	1.96	10	ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
nucleoside binding (GO:0001882)	2.21	10	ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
adenyl ribonucleotide binding (GO:0032559)	2.41	9	ATM, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
ATP binding (GO:0005524)	2.43	9	ATM, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
adenyl nucleotide binding (GO:0030554)	2.4	9	ATM, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
hydrolase activity (GO:0016787)	1.9	8	NBN, CASP8, PPM1D, KRAS, XRCC3, RAD54L, BRIP1, RAD51
identical protein binding (GO:0042802)	2.63	8	ESR1, CASP8, BARD1, TP53, RAD51, AKT1, CHEK2, TSG101
transferase activity (GO:0016740)	1.95	7	ATM, BRCA2, BARD1, PIK3CA, AKT1, BRCA1, CHEK2
macromolecular complex binding (GO:0044877)	2.61	7	ATM, CASP8, TP53, KRAS, ESR1, BRCA1, RAD51
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	6	NBN, KRAS, XRCC3, RAD54L, BRIP1, RAD51
ubiquitin protein ligase binding (GO:0031625)	4.17	6	SLC22A18, CASP8, TP53, CHEK2, BRCA1, TSG101
ubiquitin-like protein ligase binding (GO:0044389)	4.15	6	SLC22A18, CASP8, TP53, CHEK2, BRCA1, TSG101
pyrophosphatase activity (GO:0016462)	3.04	6	NBN, KRAS, XRCC3, RAD54L, BRIP1, RAD51
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	6	NBN, KRAS, XRCC3, RAD54L, BRIP1, RAD51
nucleoside-triphosphatase activity (GO:0017111)	3.09	6	NBN, KRAS, XRCC3, RAD54L, BRIP1, RAD51
kinase binding (GO:0019900)	3.32	6	PPM1D, BARD1, TP53, RB1CC1, AKT1, CHEK2
protein kinase binding (GO:0019901)	3.44	5	TP53, RB1CC1, PPM1D, CHEK2, AKT1
receptor binding (GO:0005102)	2.43	5	PHB, BRCA1, ESR1, CASP8, TP53
protein dimerization activity (GO:0046983)	2.72	5	ATM, CHEK2, BARD1, TP53, TSG101
transcription regulatory region DNA binding (GO:0044212)	3.03	4	PHB, BRCA1, ESR1, TP53
chromatin binding (GO:0003682)	3.64	4	BRCA1, ESR1, RAD51, TP53
transition metal ion binding (GO:0046914)	2.48	4	BRCA1, BARD1, ESR1, TP53
ATPase activity, coupled (GO:0042623)	3.97	4	NBN, BRIP1, RAD51, XRCC3
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	4	ATM, CHEK2, PIK3CA, AKT1
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	4	ATM, CHEK2, PIK3CA, AKT1
kinase activity (GO:0016301)	2.93	4	ATM, CHEK2, PIK3CA, AKT1
regulatory region nucleic acid binding (GO:0001067)	3.03	4	PHB, BRCA1, ESR1, TP53
protein serine/threonine kinase activity (GO:0004674)	3.64	4	ATM, CHEK2, PIK3CA, AKT1
zinc ion binding (GO:0008270)	2.66	4	BRCA1, BARD1, ESR1, TP53
ATPase activity (GO:0016887)	3.65	4	NBN, BRIP1, RAD51, XRCC3
regulatory region DNA binding (GO:0000975)	3.03	4	PHB, BRCA1, ESR1, TP53
protein complex binding (GO:0032403)	3.09	4	ATM, KRAS, CASP8, ESR1
protein kinase activity (GO:0004672)	3.27	4	ATM, CHEK2, AKT1, PIK3CA
double-stranded DNA binding (GO:0003690)	3.09	4	ESR1, RAD51, TP53, XRCC3
DNA-dependent ATPase activity (GO:0008094)	5.31	4	NBN, BRIP1, RAD51, XRCC3
enzyme regulator activity (GO:0030234)	2.85	3	AKT1, ESR1, PIK3CA
protein N-terminus binding (GO:0047485)	5.11	3	ATM, NBN, TP53
cytoskeletal protein binding (GO:0008092)	3.02	3	BRCA1, BRCA2, CDH1
transcription factor activity, sequence-specific DNA binding (GO:0003700)	2.65	3	PHB, ESR1, TP53
transcription factor binding (GO:0008134)	3.46	3	NBN, ESR1, TP53
damaged DNA binding (GO:0003684)	5.58	3	NBN, BRCA1, TP53
hydrolase activity, acting on ester bonds (GO:0016788)	3.1	3	PPM1D, RAD51, XRCC3
helicase activity (GO:0004386)	4.69	3	NBN, RAD54L, BRIP1
nucleic acid binding transcription factor activity (GO:0001071)	2.65	3	PHB, ESR1, TP53
molecular function regulator (GO:0098772)	2.51	3	ESR1, PIK3CA, AKT1
single-stranded DNA binding (GO:0003697)	5.17	3	BRCA2, RAD51, XRCC3
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981)	3.29	3	PHB, ESR1, TP53
protein homodimerization activity (GO:0042803)	3.16	3	CHEK2, BARD1, TSG101
protein C-terminus binding (GO:0008022)	4.5	2	PHB, RAD51
signal transducer activity (GO:0004871)	2.28	2	ESR1, CASP8
ATP-dependent helicase activity (GO:0008026)	5.12	2	NBN, BRIP1
ubiquitin-like protein binding (GO:0032182)	4.93	2	FAM175A, TSG101
GTPase activating protein binding (GO:0032794)	7.1	2	AKT1, CDH1
endodeoxyribonuclease activity (GO:0004520)	5.81	2	RAD51, XRCC3
phosphatidylinositol 3-kinase activity (GO:0035004)	5.49	2	ATM, PIK3CA
DNA helicase activity (GO:0003678)	5.73	2	NBN, BRIP1
G-protein coupled receptor binding (GO:0001664)	4.18	2	PHB, ESR1
ubiquitin-like protein transferase activity (GO:0019787)	3.69	2	BRCA1, BARD1
sequence-specific DNA binding (GO:0043565)	2.79	2	ESR1, TP53
structure-specific DNA binding (GO:0043566)	4.98	2	RAD51, XRCC3
sequence-specific double-stranded DNA binding (GO:1990837)	3.2	2	ESR1, TP53
ligase activity (GO:0016874)	3.72	2	BRCA1, BARD1
transcription coactivator activity (GO:0003713)	4.04	2	BRCA1, TSG101
transcription cofactor activity (GO:0003712)	3.44	2	BRCA1, TSG101
transcription factor activity, transcription factor binding (GO:0000989)	3.36	2	BRCA1, TSG101
transcription factor activity, protein binding (GO:0000988)	3.35	2	BRCA1, TSG101
1-phosphatidylinositol-3-kinase activity (GO:0016303)	5.98	2	ATM, PIK3CA
deoxyribonuclease activity (GO:0004536)	5.48	2	RAD51, XRCC3
tubulin binding (GO:0015631)	4.1	2	BRCA1, BRCA2
protease binding (GO:0002020)	5.08	2	BRCA2, TP53
ATP-dependent DNA helicase activity (GO:0004003)	6.13	2	NBN, BRIP1
nitric-oxide synthase regulator activity (GO:0030235)	7.79	2	ESR1, AKT1
DNA secondary structure binding (GO:0000217)	6.6	2	RAD51, XRCC3
lipid binding (GO:0008289)	3.26	2	ESR1, AKT1
beta-catenin binding (GO:0008013)	5.3	2	ESR1, CDH1
protein phosphatase binding (GO:0019903)	4.93	2	TP53, AKT1
phosphatase binding (GO:0019902)	4.63	2	TP53, AKT1
protein domain specific binding (GO:0019904)	3.32	2	KRAS, CASP8
core promoter binding (GO:0001047)	4.71	2	ESR1, TP53
core promoter sequence-specific DNA binding (GO:0001046)	5.12	2	ESR1, TP53
ubiquitin-protein transferase activity (GO:0004842)	3.73	2	BRCA1, BARD1
protein phosphatase 2A binding (GO:0051721)	6.41	2	TP53, AKT1
nuclease activity (GO:0004518)	4.33	2	RAD51, XRCC3
four-way junction DNA binding (GO:0000400)	7.03	2	RAD51, XRCC3
phosphatidylinositol kinase activity (GO:0052742)	5.81	2	ATM, PIK3CA
endonuclease activity (GO:0004519)	4.78	2	RAD51, XRCC3
recombinase activity (GO:0000150)	7.66	2	RAD51, XRCC3
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228)	3.98	2	ESR1, TP53
purine NTP-dependent helicase activity (GO:0070035)	5.12	2	NBN, BRIP1
ubiquitin binding (GO:0043130)	5.09	2	FAM175A, TSG101
transcription regulatory region sequence-specific DNA binding (GO:0000976)	3.24	2	ESR1, TP53
RNA binding (GO:0003723)	2.36	2	BRCA1, BARD1
protein heterodimerization activity (GO:0046982)	3.64	2	BARD1, TP53

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
protein methyltransferase activity (GO:0008276)	NEW	5.33	0.036	BRCA1, KRAS, TP53, ESR1
nucleic acid binding transcription factor activity (GO:0001071)	-	2.65	0.001	PHB, ATM, KRAS, BRCA2, ESR1, CASP8, BARD1, TP53, CDH1, RAD51, AKT1, NBN, BRCA1, CHEK2, TSG101
intramolecular oxidoreductase activity (GO:0016860)	NEW	5.75	0.018	PHB, KRAS, AKT1, ESR1
transcription corepressor activity (GO:0003714)	NEW	4.33	0.0	PHB, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
transcription coactivator activity (GO:0003713)	-	4.04	0.001	ATM, ESR1, CASP8, BARD1, TP53, CDH1, AKT1, BRCA1, CHEK2
transcription cofactor activity (GO:0003712)	-	3.44	0.0	ATM, PHB, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
nucleotide binding (GO:0000166)	-	1.96	0.044	ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, PHB, CDH1, RB1CC1, PIK3CA, ESR1, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
transferase activity (GO:0016740)	-	1.95	0.013	PHB, ATM, KRAS, BRCA2, AKT1, CASP8, PPM1D, BARD1, TP53, CDH1, RB1CC1, RAD51, ESR1, PIK3CA, NBN, BRCA1, CHEK2, TSG101
protein binding transcription factor activity (GO:0000988)	-	3.35	0.0	PHB, ATM, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
regulatory region nucleic acid binding (GO:0001067)	-	3.03	0.009	PHB, ATM, AKT1, CASP8, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
helicase activity (GO:0004386)	-	4.69	0.004	ATM, TP53, CHEK2, BRIP1, RAD54L, RAD51
protein kinase binding (GO:0019901)	-	3.44	0.006	ATM, ESR1, BARD1, PIK3CA, RB1CC1, TP53, AKT1, BRCA1, CHEK2, RAD51
kinase binding (GO:0019900)	-	3.32	0.002	ATM, KRAS, AKT1, BARD1, PIK3CA, RB1CC1, TP53, ESR1, BRCA1, CHEK2, RAD51
protein domain specific binding (GO:0019904)	-	3.32	0.006	ATM, KRAS, AKT1, CASP8, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
binding, bridging (GO:0060090)	NEW	4.57	0.002	KRAS, ESR1, TP53, RB1CC1, PIK3CA, AKT1, BRCA1
transcription regulatory region DNA binding (GO:0044212)	-	3.03	0.008	PHB, ATM, AKT1, CASP8, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	-	3.03	0.0	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, TP53, CDH1, PIK3CA, ESR1, RAD54L, BRIP1, CHEK2, RAD51
carbohydrate derivative binding (GO:0097367)	-	2.03	0.013	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, RAD51, ESR1, PIK3CA, NBN, CHEK2, RAD54L, BRIP1, BRCA1, HMMR
hydrolase activity, acting on acid anhydrides (GO:0016817)	-	3.03	0.0	ATM, PHB, XRCC3, KRAS, BRCA2, AKT1, TP53, CDH1, PIK3CA, ESR1, RAD54L, BRIP1, CHEK2, RAD51
sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0000981)	-	3.29	0.002	PHB, ATM, NBN, AKT1, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
phospholipase activity (GO:0004620)	NEW	5.16	0.008	ATM, TP53, CASP8, AKT1, CDH1
lipase activity (GO:0016298)	NEW	4.96	0.015	ATM, TP53, CASP8, AKT1, CDH1
cytokine receptor binding (GO:0005126)	NEW	4.14	0.002	ATM, KRAS, ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1
cytokine activity (GO:0005125)	NEW	4.34	0.012	ATM, ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1
RNA polymerase II regulatory region DNA binding (GO:0001012)	NEW	3.36	0.014	ATM, AKT1, CASP8, TP53, ESR1, BRCA1, CHEK2, TSG101
enhancer sequence-specific DNA binding (GO:0001158)	NEW	5.36	0.003	TP53, BRCA1, ESR1, CHEK2, AKT1
steroid hormone receptor binding (GO:0035258)	NEW	5.32	0.044	BRCA1, ESR1, TP53, AKT1
ATPase activity (GO:0016887)	-	3.65	0.01	PHB, ATM, BRCA2, XRCC3, TP53, ESR1, BRIP1, RAD51
DNA binding (GO:0003677)	-	1.92	0.003	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, PALB2, BARD1, TP53, CDH1, RAD51, ESR1, NBN, CHEK2, BRCA1, BRIP1, RAD54L, TSG101
nucleoside phosphate binding (GO:1901265)	-	1.96	0.044	ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, PHB, CDH1, RB1CC1, PIK3CA, ESR1, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
ATPase activity, coupled (GO:0042623)	-	3.97	0.007	PHB, ATM, XRCC3, TP53, ESR1, BRIP1, RAD51
transcription factor binding transcription factor activity (GO:0000989)	-	3.36	0.0	ATM, PHB, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
ribonucleoside binding (GO:0032549)	-	2.22	0.017	ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, PHB, CDH1, PIK3CA, ESR1, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
purine nucleotide binding (GO:0017076)	-	2.19	0.022	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, NBN, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
oxidoreductase activity (GO:0016491)	NEW	3.12	0.024	ATM, ESR1, BARD1, TP53, CDH1, RB1CC1, NQO2, AKT1, BRCA1, CHEK2, HMMR
histone deacetylase binding (GO:0042826)	NEW	5.08	0.049	PHB, ATM, ESR1, TP53
ATP binding (GO:0005524)	-	2.43	0.002	ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, PHB, CDH1, PIK3CA, ESR1, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
GTP binding (GO:0005525)	NEW	3.78	0.045	ATM, KRAS, ESR1, CDH1, PIK3CA, AKT1, CHEK2, RAD51
tumor necrosis factor receptor superfamily binding (GO:0032813)	NEW	5.89	0.004	ATM, CASP8, TP53, AKT1
protein kinase regulator activity (GO:0019887)	NEW	4.6	0.006	ATM, ESR1, TP53, PIK3CA, AKT1, BRCA1
1-phosphatidylinositol-3-kinase activity (GO:0016303)	-	5.98	0.019	ATM, PIK3CA
kinase activity (GO:0016301)	-	2.93	0.02	PHB, ATM, KRAS, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
hydrolase activity, acting on ester bonds (GO:0016788)	-	3.1	0.001	ATM, ESR1, CASP8, PPM1D, BARD1, TP53, CDH1, PIK3CA, AKT1, CHEK2, BRCA1, RAD54L, RAD51
ubiquitin-protein transferase activity (GO:0004842)	-	3.73	0.007	ESR1, BARD1, CDH1, TP53, AKT1, BRCA1, CHEK2
RNA polymerase II transcription factor binding (GO:0001085)	NEW	5.08	0.012	TP53, BRCA1, ESR1, CHEK2, CDH1
DNA-dependent ATPase activity (GO:0008094)	-	5.31	0.0	ATM, RAD51, BRIP1, TP53, XRCC3
protein binding, bridging (GO:0030674)	NEW	4.68	0.014	ESR1, KRAS, RB1CC1, TP53, AKT1, BRCA1
phosphatidylinositol kinase activity (GO:0052742)	-	5.81	0.044	ATM, PIK3CA
transferase activity, transferring phosphorus-containing groups (GO:0016772)	-	2.77	0.019	PHB, ATM, KRAS, NBN, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
glycosaminoglycan binding (GO:0005539)	NEW	4.42	0.0	ATM, AKT1, CASP8, TP53, RB1CC1, CDH1, ESR1, BRCA1, CHEK2, HMMR
guanyl nucleotide binding (GO:0019001)	NEW	3.73	0.01	ATM, KRAS, ESR1, TP53, CDH1, PIK3CA, AKT1, CHEK2, RAD51
transcription regulatory region sequence-specific DNA binding (GO:0000976)	-	3.24	0.035	ATM, AKT1, CASP8, TP53, ESR1, BRCA1, CHEK2, TSG101
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)	NEW	3.37	0.013	ATM, AKT1, CASP8, TP53, ESR1, BRCA1, CHEK2, TSG101
regulatory region DNA binding (GO:0000975)	-	3.03	0.009	PHB, ATM, AKT1, CASP8, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
purine ribonucleotide binding (GO:0032555)	-	2.2	0.019	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, NBN, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
gamma-tubulin binding (GO:0043015)	NEW	6.56	0.021	BARD1, BRCA1, BRCA2
protein dimerization activity (GO:0046983)	-	2.72	0.0	ATM, PHB, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, RAD51, ESR1, PIK3CA, BRCA1, BRIP1, CHEK2, TSG101
protein heterodimerization activity (GO:0046982)	-	3.64	0.002	ATM, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, ESR1, BRCA1, CHEK2
purine ribonucleoside binding (GO:0032550)	-	2.22	0.017	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, NBN, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
ribonucleotide binding (GO:0032553)	-	2.19	0.021	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, NBN, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
protein C-terminus binding (GO:0008022)	-	4.5	0.001	ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1, CHEK2, RAD51
phosphatase activity (GO:0016791)	NEW	4.11	0.002	ATM, CASP8, PPM1D, TP53, CDH1, AKT1, CHEK2, RAD51
calcium-dependent protein binding (GO:0048306)	NEW	5.68	0.001	TP53, KRAS, AKT1, TSG101, PIK3CA
enzyme binding (GO:0019899)	-	2.27	0.0	ATM, NBN, SLC22A18, KRAS, BRCA2, AKT1, CASP8, PPM1D, BARD1, TSG101, TP53, PHB, CDH1, RB1CC1, RAD51, PIK3CA, ESR1, BRCA1, CHEK2, HMMR
phosphoric ester hydrolase activity (GO:0042578)	NEW	3.82	0.031	ATM, CASP8, PPM1D, TP53, CDH1, AKT1, CHEK2, RAD51
enzyme inhibitor activity (GO:0004857)	NEW	3.78	0.013	ATM, ESR1, CASP8, BARD1, PIK3CA, CDH1, TP53, AKT1, BRCA1
kinase regulator activity (GO:0019207)	NEW	4.5	0.017	ATM, ESR1, TP53, PIK3CA, AKT1, BRCA1
anion binding (GO:0043168)	NEW	4.17	0.011	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, RAD51, ESR1, PIK3CA, NBN, CHEK2, RAD54L, BRIP1, BRCA1, TSG101
sequence-specific DNA binding (GO:0043565)	-	2.79	0.0	ATM, NBN, KRAS, BRCA2, AKT1, CASP8, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
structure-specific DNA binding (GO:0043566)	-	4.98	0.0	ATM, XRCC3, BRCA2, ESR1, TP53, CDH1, AKT1, CHEK2, RAD51
receptor regulator activity (GO:0030545)	NEW	5.91	0.029	TP53, ESR1, AKT1, CDH1
guanyl ribonucleotide binding (GO:0032561)	NEW	3.73	0.01	ATM, KRAS, ESR1, TP53, CDH1, PIK3CA, AKT1, CHEK2, RAD51
protease binding (GO:0002020)	-	5.08	0.008	PHB, CASP8, BRCA2, TP53, AKT1
protein complex binding (GO:0032403)	-	3.09	0.008	ATM, KRAS, AKT1, CASP8, RAD51, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
double-stranded DNA binding (GO:0003690)	-	3.09	0.0	ATM, XRCC3, ESR1, CDH1, TP53, AKT1, RAD51
protein homodimerization activity (GO:0042803)	-	3.16	0.0	ATM, PHB, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, RAD51, ESR1, PIK3CA, BRCA1, BRIP1, CHEK2, TSG101
transporter activity (GO:0005215)	NEW	2.57	0.008	ATM, PHB, SLC22A18, KRAS, AKT1, CASP8, BARD1, RAD51, TP53, CDH1, RB1CC1, PIK3CA, ESR1, TSG101
transcription factor binding (GO:0008134)	-	3.46	0.0	PHB, ATM, XRCC3, NBN, AKT1, CASP8, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
protein kinase inhibitor activity (GO:0004860)	NEW	5.28	0.027	ATM, BRCA1, ESR1, AKT1
cofactor binding (GO:0048037)	NEW	4.16	0.042	PHB, ESR1, CDH1, RB1CC1, TP53, AKT1, CHEK2
enhancer binding (GO:0035326)	NEW	5.21	0.008	TP53, BRCA1, ESR1, CHEK2, AKT1
cysteine-type endopeptidase inhibitor activity (GO:0004869)	NEW	5.71	0.001	TP53, CASP8, ESR1, AKT1, CDH1
ubiquitin protein ligase binding (GO:0031625)	-	4.17	0.0	ATM, SLC22A18, CASP8, TP53, AKT1, BRCA1, CHEK2, TSG101
protein N-terminus binding (GO:0047485)	-	5.11	0.0	ATM, NBN, BARD1, TP53, AKT1, CHEK2, TSG101
adenyl nucleotide binding (GO:0030554)	-	2.4	0.002	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, NBN, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001228)	-	3.98	0.017	NBN, ESR1, TP53, AKT1, BRCA1, CHEK2, TSG101
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	-	3.08	0.006	PHB, ATM, KRAS, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
RNA binding (GO:0003723)	-	2.36	0.003	PHB, NBN, KRAS, AKT1, CASP8, PPM1D, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, BRIP1, RAD51
protein binding (GO:0005515)	-	0.46	0.0	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, SLC22A18, BARD1, CDH1, AKT1, BRIP1, BRCA2, RAD51, ESR1, CHEK2, TSG101
receptor binding (GO:0005102)	-	2.43	0.003	ATM, PHB, XRCC3, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, HMMR, CHEK2, TSG101
p53 binding (GO:0002039)	NEW	5.53	0.009	ESR1, RAD51, TP53, CDH1
damaged DNA binding (GO:0003684)	-	5.58	0.0	ATM, NBN, BRCA1, RAD51, TP53
small conjugating protein ligase binding (GO:0044389)	-	4.15	0.0	ATM, SLC22A18, CASP8, TP53, AKT1, BRCA1, CHEK2, TSG101
phosphatidylinositol 3-kinase activity (GO:0035004)	-	5.49	0.019	ATM, PIK3CA
purine nucleoside binding (GO:0001883)	-	2.22	0.017	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, NBN, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
nucleoside binding (GO:0001882)	-	2.21	0.018	ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, PHB, CDH1, PIK3CA, ESR1, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
oxidoreductase activity, acting on CH or CH2 groups (GO:0016725)	NEW	7.44	0.004	BARD1, ESR1, AKT1
pyrophosphatase activity (GO:0016462)	-	3.04	0.0	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, TP53, CDH1, PIK3CA, ESR1, RAD54L, BRIP1, CHEK2, RAD51
structural molecule activity (GO:0005198)	NEW	3.1	0.006	KRAS, ESR1, CASP8, TP53, CDH1, RB1CC1, RAD51, AKT1, BRCA1, BRIP1, TSG101
protein serine/threonine kinase activity (GO:0004674)	-	3.64	0.028	PHB, ATM, ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1, CHEK2
protein kinase activity (GO:0004672)	-	3.27	0.01	ATM, PHB, KRAS, ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1, CHEK2, RAD51
kinase inhibitor activity (GO:0019210)	NEW	5.25	0.039	ATM, BRCA1, ESR1, AKT1
nitric-oxide synthase regulator activity (GO:0030235)	-	7.79	0.006	ESR1, AKT1
nucleoside-triphosphatase activity (GO:0017111)	-	3.09	0.0	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, TP53, CDH1, PIK3CA, ESR1, RAD54L, BRIP1, CHEK2, RAD51
ligase activity (GO:0016874)	-	3.72	0.013	ATM, BARD1, CDH1, TP53, ESR1, BRCA1, CHEK2, RAD51
sequence-specific DNA binding transcription factor activity (GO:0003700)	-	2.65	0.001	PHB, ATM, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, RAD51, ESR1, NBN, BRCA1, CHEK2, TSG101

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	24	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1, BRIP1, HMMR, BRCA2, RAD51, ESR1, CHEK2, TSG101
metabolic process (GO:0008152)	0.58	24	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, AKT1, BRIP1, HMMR, BRCA2, NQO2, RAD51, ESR1, CHEK2, TSG101
organic substance metabolic process (GO:0071704)	0.63	23	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, AKT1, BRIP1, HMMR, BRCA2, TSG101, ESR1, CHEK2, RAD51
macromolecule metabolic process (GO:0043170)	0.83	23	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, AKT1, BRIP1, HMMR, BRCA2, TSG101, ESR1, CHEK2, RAD51
primary metabolic process (GO:0044238)	0.69	22	ATM, PALB2, TP53, FAM175A, RB1CC1, KRAS, XRCC3, RAD54L, PHB, CASP8, PPM1D, PIK3CA, BRCA1, NBN, BARD1, AKT1, BRIP1, BRCA2, TSG101, ESR1, CHEK2, RAD51
response to stimulus (GO:0050896)	1.22	22	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1, BRIP1, BRCA2, ESR1, CHEK2, RAD51
biological regulation (GO:0065007)	0.39	22	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1, BRIP1, BRCA2, TSG101, ESR1, CHEK2, RAD51
regulation of biological process (GO:0050789)	0.45	22	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1, BRIP1, BRCA2, TSG101, ESR1, CHEK2, RAD51
regulation of cellular process (GO:0050794)	0.5	22	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1, BRIP1, BRCA2, TSG101, ESR1, CHEK2, RAD51
cellular response to stimulus (GO:0051716)	1.97	21	ATM, NBN, BRCA2, XRCC3, CASP8, PPM1D, PALB2, CDH1, BARD1, TP53, PHB, FAM175A, RB1CC1, PIK3CA, AKT1, CHEK2, BRCA1, ESR1, BRIP1, RAD54L, RAD51
cellular macromolecule metabolic process (GO:0044260)	0.93	21	ATM, PHB, XRCC3, KRAS, BRCA2, AKT1, PPM1D, PALB2, BARD1, RAD51, TP53, FAM175A, RB1CC1, PIK3CA, ESR1, NBN, CHEK2, BRCA1, BRIP1, RAD54L, TSG101
cellular metabolic process (GO:0044237)	0.69	21	ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, PPM1D, PALB2, BARD1, RAD51, TP53, PHB, FAM175A, RB1CC1, PIK3CA, ESR1, CHEK2, BRCA1, BRIP1, RAD54L, TSG101
single-organism process (GO:0044699)	0.48	21	ATM, NBN, SLC22A18, KRAS, BRCA2, AKT1, CASP8, PALB2, PPM1D, TP53, PHB, CDH1, RB1CC1, PIK3CA, ESR1, CHEK2, BRCA1, BRIP1, RAD54L, TSG101, NQO2
cellular component organization or biogenesis (GO:0071840)	1.22	21	ATM, PHB, XRCC3, KRAS, BRCA2, AKT1, CASP8, PALB2, CDH1, TP53, FAM175A, RB1CC1, RAD51, ESR1, PIK3CA, NBN, CHEK2, RAD54L, BRIP1, BRCA1, TSG101
cellular component organization (GO:0016043)	1.24	21	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, PALB2, CDH1, RAD51, TP53, FAM175A, RB1CC1, PIK3CA, ESR1, NBN, CHEK2, RAD54L, BRIP1, BRCA1, TSG101
regulation of primary metabolic process (GO:0080090)	1.08	19	ATM, PHB, KRAS, BRCA2, AKT1, CASP8, CDH1, BARD1, RAD51, TP53, FAM175A, RB1CC1, PIK3CA, ESR1, NBN, BRCA1, BRIP1, CHEK2, TSG101
regulation of metabolic process (GO:0019222)	1.02	19	ATM, PHB, KRAS, BRCA2, AKT1, CASP8, CDH1, BARD1, RAD51, TP53, FAM175A, RB1CC1, PIK3CA, ESR1, NBN, BRCA1, BRIP1, CHEK2, TSG101
regulation of macromolecule metabolic process (GO:0060255)	1.08	19	PHB, ATM, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, RAD51, ESR1, PIK3CA, NBN, FAM175A, BRCA1, BRIP1, CHEK2, TSG101
regulation of cellular metabolic process (GO:0031323)	1.07	19	ATM, PHB, KRAS, BRCA2, AKT1, CASP8, CDH1, BARD1, RAD51, TP53, FAM175A, RB1CC1, PIK3CA, ESR1, NBN, BRCA1, BRIP1, CHEK2, TSG101
positive regulation of biological process (GO:0048518)	1.2	19	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, CDH1, BARD1, TP53, FAM175A, RB1CC1, RAD51, ESR1, PIK3CA, NBN, BRCA1, CHEK2, TSG101
negative regulation of biological process (GO:0048519)	1.33	19	PHB, ATM, KRAS, BRCA2, AKT1, CASP8, PPM1D, PALB2, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, NBN, BRCA1, BRIP1, CHEK2, TSG101
negative regulation of cellular process (GO:0048523)	1.41	19	ATM, PHB, KRAS, BRCA2, AKT1, CASP8, BARD1, PALB2, PPM1D, TP53, CDH1, RB1CC1, PIK3CA, ESR1, NBN, BRCA1, BRIP1, CHEK2, TSG101
positive regulation of cellular process (GO:0048522)	1.3	19	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, CDH1, BARD1, TP53, FAM175A, RB1CC1, RAD51, ESR1, PIK3CA, NBN, BRCA1, CHEK2, TSG101
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	18	PHB, ATM, KRAS, BRCA2, AKT1, CDH1, BARD1, TP53, FAM175A, RB1CC1, RAD51, ESR1, PIK3CA, NBN, BRCA1, BRIP1, CHEK2, TSG101
organelle organization (GO:0006996)	2.02	18	PHB, ATM, KRAS, BRCA2, XRCC3, CASP8, PALB2, TP53, RB1CC1, RAD51, AKT1, PIK3CA, NBN, CHEK2, RAD54L, BRIP1, BRCA1, TSG101
nitrogen compound metabolic process (GO:0006807)	1.13	18	ATM, NBN, XRCC3, BRCA2, AKT1, PALB2, BARD1, TP53, PHB, FAM175A, RB1CC1, RAD51, ESR1, CHEK2, RAD54L, BRIP1, BRCA1, HMMR
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	18	PHB, ATM, KRAS, BRCA2, AKT1, CDH1, BARD1, TP53, FAM175A, RB1CC1, RAD51, ESR1, PIK3CA, NBN, BRCA1, BRIP1, CHEK2, TSG101
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	17	PHB, ATM, KRAS, BRCA2, AKT1, CASP8, CDH1, BARD1, TP53, FAM175A, RB1CC1, PIK3CA, ESR1, NBN, BRCA1, CHEK2, RAD51
regulation of response to stimulus (GO:0048583)	1.54	17	ATM, PHB, KRAS, NBN, AKT1, CASP8, BARD1, RAD51, TP53, FAM175A, RB1CC1, PIK3CA, ESR1, BRCA1, BRIP1, CHEK2, TSG101
response to stress (GO:0006950)	1.8	17	ATM, NBN, BRCA2, XRCC3, CASP8, PPM1D, PALB2, BARD1, TP53, FAM175A, RB1CC1, AKT1, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
cellular nitrogen compound metabolic process (GO:0034641)	1.22	17	ATM, NBN, XRCC3, BRCA2, AKT1, PALB2, BARD1, TP53, PHB, FAM175A, RB1CC1, ESR1, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
single-organism cellular process (GO:0044763)	0.65	17	ATM, NBN, KRAS, BRCA2, AKT1, CASP8, PPM1D, TP53, PHB, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, BRIP1, CHEK2, TSG101
positive regulation of metabolic process (GO:0009893)	1.74	17	PHB, ATM, KRAS, BRCA2, AKT1, CASP8, CDH1, BARD1, TP53, FAM175A, RB1CC1, PIK3CA, ESR1, NBN, BRCA1, CHEK2, RAD51
nucleobase-containing compound metabolic process (GO:0006139)	1.35	16	ATM, NBN, BRCA2, XRCC3, PALB2, BARD1, TP53, PHB, FAM175A, RB1CC1, ESR1, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
organic substance biosynthetic process (GO:1901576)	1.34	16	ATM, NBN, XRCC3, BRCA2, AKT1, PALB2, BARD1, TP53, PHB, RB1CC1, PIK3CA, ESR1, BRCA1, BRIP1, CHEK2, RAD51
positive regulation of cellular metabolic process (GO:0031325)	1.81	16	ATM, PHB, KRAS, BRCA2, AKT1, CASP8, CDH1, TP53, FAM175A, RB1CC1, PIK3CA, ESR1, NBN, BRCA1, CHEK2, RAD51
cellular aromatic compound metabolic process (GO:0006725)	1.3	16	PHB, ATM, BRCA2, ESR1, PALB2, BARD1, TP53, FAM175A, RB1CC1, XRCC3, NBN, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
nucleic acid metabolic process (GO:0090304)	1.46	16	ATM, NBN, BRCA2, XRCC3, PALB2, BARD1, TP53, PHB, FAM175A, RB1CC1, ESR1, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
cellular biosynthetic process (GO:0044249)	1.37	16	PHB, ATM, BRCA2, XRCC3, PALB2, BARD1, TP53, RB1CC1, PIK3CA, AKT1, NBN, BRCA1, ESR1, BRIP1, CHEK2, RAD51
biosynthetic process (GO:0009058)	1.32	16	PHB, ATM, XRCC3, BRCA2, AKT1, PALB2, BARD1, TP53, RB1CC1, PIK3CA, ESR1, NBN, BRCA1, BRIP1, CHEK2, RAD51
cellular response to stress (GO:0033554)	2.51	16	ATM, NBN, BRCA2, XRCC3, PPM1D, PALB2, BARD1, TP53, FAM175A, RB1CC1, AKT1, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
organic cyclic compound metabolic process (GO:1901360)	1.26	16	ATM, NBN, BRCA2, XRCC3, PALB2, BARD1, TP53, PHB, FAM175A, RB1CC1, ESR1, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
heterocycle metabolic process (GO:0046483)	1.31	16	PHB, ATM, BRCA2, XRCC3, PALB2, BARD1, TP53, FAM175A, RB1CC1, ESR1, NBN, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
regulation of cell communication (GO:0010646)	1.73	15	ATM, NBN, KRAS, AKT1, CASP8, BARD1, TP53, PHB, RB1CC1, PIK3CA, ESR1, BRCA1, BRIP1, CHEK2, TSG101
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	15	PHB, ATM, BRCA2, XRCC3, PALB2, BARD1, TP53, RB1CC1, ESR1, AKT1, NBN, BRCA1, BRIP1, CHEK2, RAD51
regulation of signal transduction (GO:0009966)	1.84	15	ATM, NBN, KRAS, AKT1, CASP8, BARD1, TP53, PHB, RB1CC1, PIK3CA, ESR1, BRCA1, BRIP1, CHEK2, TSG101
regulation of protein metabolic process (GO:0051246)	1.93	15	ATM, NBN, KRAS, AKT1, CASP8, BARD1, RAD51, TP53, PHB, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
macromolecule biosynthetic process (GO:0009059)	1.61	15	PHB, ATM, BRCA2, XRCC3, PALB2, BARD1, TP53, RB1CC1, ESR1, AKT1, NBN, BRCA1, BRIP1, CHEK2, RAD51
cell cycle process (GO:0022402)	2.75	15	ATM, NBN, BRCA2, PPM1D, BARD1, RAD51, TP53, FAM175A, TSG101, XRCC3, CHEK2, RAD54L, BRIP1, BRCA1, HMMR
cellular macromolecule biosynthetic process (GO:0034645)	1.66	15	PHB, ATM, XRCC3, BRCA2, AKT1, PALB2, BARD1, TP53, RB1CC1, ESR1, NBN, BRCA1, BRIP1, CHEK2, RAD51
regulation of signaling (GO:0023051)	1.72	15	ATM, PHB, KRAS, NBN, AKT1, CASP8, BARD1, TP53, RB1CC1, PIK3CA, ESR1, BRCA1, BRIP1, CHEK2, TSG101
response to chemical (GO:0042221)	1.98	15	PHB, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
regulation of biological quality (GO:0065008)	1.68	15	ATM, PHB, XRCC3, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, RB1CC1, PIK3CA, ESR1, NBN, CHEK2, RAD51
regulation of gene expression (GO:0010468)	1.37	15	ATM, PHB, KRAS, BRCA2, AKT1, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, BRIP1, CHEK2, TSG101
developmental process (GO:0032502)	1.36	14	ATM, NBN, KRAS, BRCA2, AKT1, CASP8, PALB2, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2
single-organism developmental process (GO:0044767)	1.49	14	ATM, NBN, KRAS, BRCA2, AKT1, CASP8, PALB2, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2
regulation of cellular protein metabolic process (GO:0032268)	1.99	14	PHB, ATM, KRAS, NBN, AKT1, CASP8, TP53, RB1CC1, RAD51, ESR1, PIK3CA, BRCA1, CHEK2, TSG101
regulation of biosynthetic process (GO:0009889)	1.37	14	PHB, ATM, KRAS, BRCA2, AKT1, TP53, RB1CC1, CDH1, ESR1, NBN, BRCA1, BRIP1, CHEK2, TSG101
protein metabolic process (GO:0019538)	1.45	14	ATM, PHB, KRAS, BRCA2, CASP8, PPM1D, BARD1, TP53, RB1CC1, PIK3CA, AKT1, BRCA1, CHEK2, TSG101
regulation of cellular biosynthetic process (GO:0031326)	1.38	14	PHB, ATM, KRAS, BRCA2, AKT1, TP53, RB1CC1, CDH1, ESR1, NBN, BRCA1, BRIP1, CHEK2, TSG101
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	14	PHB, ATM, KRAS, BRCA2, AKT1, TP53, RB1CC1, CDH1, ESR1, NBN, BRCA1, BRIP1, CHEK2, TSG101
cellular response to DNA damage stimulus (GO:0006974)	3.17	14	ATM, NBN, BRCA2, XRCC3, PALB2, BARD1, TP53, FAM175A, AKT1, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	14	ATM, PHB, BRCA2, XRCC3, PALB2, BARD1, TP53, RB1CC1, ESR1, NBN, BRCA1, BRIP1, CHEK2, RAD51
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	14	PHB, ATM, KRAS, BRCA2, AKT1, TP53, RB1CC1, CDH1, ESR1, NBN, BRCA1, BRIP1, CHEK2, TSG101
DNA metabolic process (GO:0006259)	3.09	14	ATM, NBN, BRCA2, PALB2, BARD1, TP53, PHB, FAM175A, XRCC3, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
aromatic compound biosynthetic process (GO:0019438)	1.7	14	PHB, ATM, BRCA2, XRCC3, PALB2, BARD1, TP53, RB1CC1, ESR1, NBN, BRCA1, BRIP1, CHEK2, RAD51
regulation of intracellular signal transduction (GO:1902531)	2.31	14	ATM, NBN, KRAS, AKT1, CASP8, BARD1, TP53, PHB, PIK3CA, ESR1, BRCA1, BRIP1, CHEK2, TSG101
organic cyclic compound biosynthetic process (GO:1901362)	1.66	14	ATM, PHB, BRCA2, XRCC3, PALB2, BARD1, TP53, RB1CC1, ESR1, NBN, BRCA1, BRIP1, CHEK2, RAD51
heterocycle biosynthetic process (GO:0018130)	1.7	14	PHB, ATM, BRCA2, XRCC3, PALB2, BARD1, TP53, RB1CC1, ESR1, NBN, BRCA1, BRIP1, CHEK2, RAD51
regulation of phosphorylation (GO:0042325)	2.5	13	ATM, NBN, KRAS, AKT1, BARD1, RAD51, TP53, PHB, RB1CC1, PIK3CA, ESR1, CHEK2, TSG101
response to abiotic stimulus (GO:0009628)	2.8	13	ATM, BRCA2, XRCC3, CASP8, PPM1D, TP53, FAM175A, KRAS, AKT1, CHEK2, BRCA1, RAD54L, RAD51
multicellular organismal process (GO:0032501)	1.45	13	ATM, NBN, SLC22A18, KRAS, BRCA2, AKT1, PALB2, TP53, PIK3CA, ESR1, RAD54L, BRCA1, NQO2
regulation of phosphate metabolic process (GO:0019220)	2.35	13	ATM, PHB, KRAS, NBN, AKT1, BARD1, TP53, RB1CC1, RAD51, ESR1, PIK3CA, CHEK2, TSG101
DNA repair (GO:0006281)	3.59	13	ATM, NBN, BRCA2, PALB2, BARD1, TP53, FAM175A, XRCC3, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
regulation of RNA metabolic process (GO:0051252)	1.52	13	PHB, KRAS, BRCA2, AKT1, BARD1, TP53, RB1CC1, CDH1, ESR1, BRCA1, BRIP1, CHEK2, TSG101
positive regulation of protein metabolic process (GO:0051247)	2.43	13	ATM, NBN, KRAS, AKT1, CASP8, BARD1, TP53, PHB, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2
cellular protein modification process (GO:0006464)	1.79	13	PHB, ATM, KRAS, BRCA2, PPM1D, BARD1, TP53, RB1CC1, PIK3CA, AKT1, BRCA1, CHEK2, TSG101
regulation of programmed cell death (GO:0043067)	2.49	13	ATM, PHB, KRAS, AKT1, CASP8, PALB2, BARD1, TP53, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2
regulation of phosphorus metabolic process (GO:0051174)	2.35	13	PHB, ATM, KRAS, NBN, AKT1, BARD1, TP53, RB1CC1, RAD51, ESR1, PIK3CA, CHEK2, TSG101
macromolecule modification (GO:0043412)	1.73	13	PHB, ATM, KRAS, BRCA2, PPM1D, BARD1, TP53, RB1CC1, PIK3CA, AKT1, BRCA1, CHEK2, TSG101
protein modification process (GO:0036211)	1.79	13	PHB, ATM, KRAS, BRCA2, PPM1D, BARD1, TP53, RB1CC1, PIK3CA, AKT1, BRCA1, CHEK2, TSG101
signal transduction (GO:0007165)	1.28	13	PHB, ATM, KRAS, BRCA2, AKT1, CASP8, TP53, RB1CC1, PIK3CA, ESR1, NBN, BRCA1, CHEK2
regulation of protein modification process (GO:0031399)	2.32	13	ATM, NBN, KRAS, AKT1, RAD51, TP53, PHB, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
cellular protein metabolic process (GO:0044267)	1.63	13	PHB, ATM, KRAS, BRCA2, PPM1D, BARD1, TP53, RB1CC1, PIK3CA, AKT1, BRCA1, CHEK2, TSG101
regulation of cell death (GO:0010941)	2.43	13	ATM, PHB, KRAS, AKT1, CASP8, PALB2, BARD1, TP53, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2
regulation of apoptotic process (GO:0042981)	2.5	13	ATM, PHB, KRAS, AKT1, CASP8, PALB2, BARD1, TP53, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2
negative regulation of metabolic process (GO:0009892)	1.93	12	PHB, ATM, BRCA2, ESR1, CASP8, BARD1, TP53, AKT1, NBN, BRCA1, CHEK2, TSG101
negative regulation of cellular metabolic process (GO:0031324)	2.01	12	PHB, ATM, BRCA2, ESR1, CASP8, BARD1, TP53, AKT1, NBN, BRCA1, CHEK2, TSG101
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	12	PHB, ATM, BRCA2, AKT1, CASP8, BARD1, TP53, ESR1, NBN, BRCA1, CHEK2, TSG101
double-strand break repair (GO:0006302)	4.73	12	ATM, NBN, BRCA2, PALB2, BARD1, FAM175A, XRCC3, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
single-multicellular organism process (GO:0044707)	1.78	12	ATM, NBN, KRAS, BRCA2, AKT1, PALB2, TP53, PIK3CA, ESR1, RAD54L, BRCA1, NQO2
response to radiation (GO:0009314)	3.69	12	ATM, BRCA2, XRCC3, PPM1D, TP53, FAM175A, KRAS, AKT1, CHEK2, BRCA1, RAD54L, RAD51
regulation of RNA biosynthetic process (GO:2001141)	1.55	12	PHB, KRAS, BRCA2, AKT1, TP53, RB1CC1, CDH1, ESR1, BRCA1, BRIP1, CHEK2, TSG101
anatomical structure development (GO:0048856)	1.58	12	ATM, NBN, KRAS, BRCA2, AKT1, PALB2, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	12	PHB, KRAS, BRCA2, AKT1, TP53, RB1CC1, CDH1, ESR1, BRCA1, BRIP1, CHEK2, TSG101
regulation of transcription, DNA-templated (GO:0006355)	1.56	12	PHB, KRAS, BRCA2, AKT1, TP53, RB1CC1, CDH1, ESR1, BRCA1, BRIP1, CHEK2, TSG101
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	12	PHB, ATM, KRAS, NBN, AKT1, CASP8, TP53, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	12	PHB, ATM, BRCA2, AKT1, TP53, FAM175A, CDH1, ESR1, NBN, BRCA1, CHEK2, RAD51
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	12	ATM, NBN, BRCA2, AKT1, TP53, PHB, FAM175A, CDH1, ESR1, BRCA1, CHEK2, RAD51
regulation of protein phosphorylation (GO:0001932)	2.57	12	PHB, ATM, KRAS, NBN, ESR1, TP53, RB1CC1, RAD51, AKT1, PIK3CA, CHEK2, TSG101
response to organic substance (GO:0010033)	2.2	12	PHB, XRCC3, KRAS, BRCA2, ESR1, CASP8, PIK3CA, CDH1, AKT1, BRCA1, CHEK2, RAD51
regulation of cell proliferation (GO:0042127)	2.41	11	PHB, ATM, BRCA2, AKT1, PPM1D, TP53, KRAS, ESR1, BRCA1, BRIP1, TSG101
intracellular signal transduction (GO:0035556)	2.39	11	ATM, NBN, KRAS, BRCA2, CASP8, PIK3CA, RB1CC1, TP53, AKT1, BRCA1, CHEK2
positive regulation of protein modification process (GO:0031401)	2.7	11	ATM, NBN, KRAS, ESR1, TP53, PHB, RB1CC1, PIK3CA, AKT1, BRCA1, CHEK2
cellular response to chemical stimulus (GO:0070887)	2.57	11	PHB, ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1, BRCA1, BRIP1, CHEK2, RAD51
positive regulation of phosphorylation (GO:0042327)	2.9	10	ATM, NBN, KRAS, ESR1, TP53, PHB, RB1CC1, PIK3CA, AKT1, CHEK2
regulation of DNA metabolic process (GO:0051052)	3.87	10	ATM, NBN, BRCA2, TP53, FAM175A, PIK3CA, AKT1, BRCA1, CHEK2, RAD51
positive regulation of phosphate metabolic process (GO:0045937)	2.78	10	ATM, NBN, KRAS, ESR1, TP53, PHB, RB1CC1, PIK3CA, AKT1, CHEK2
regulation of cell cycle (GO:0051726)	2.93	10	ATM, NBN, BRCA2, XRCC3, BARD1, TP53, AKT1, BRCA1, CHEK2, TSG101
cellular developmental process (GO:0048869)	1.82	10	PHB, ATM, BRCA2, AKT1, CASP8, TP53, KRAS, ESR1, CHEK2, TSG101
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	10	PHB, ATM, KRAS, NBN, ESR1, TP53, RB1CC1, PIK3CA, AKT1, CHEK2
positive regulation of response to stimulus (GO:0048584)	2.18	10	ATM, PHB, KRAS, AKT1, CASP8, TP53, FAM175A, PIK3CA, ESR1, BRCA1
homeostatic process (GO:0042592)	2.61	10	ATM, NBN, XRCC3, BRCA2, ESR1, BARD1, PIK3CA, KRAS, AKT1, RAD51
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	10	PHB, ATM, BRCA2, BARD1, TP53, ESR1, NBN, BRCA1, CHEK2, TSG101
negative regulation of cell death (GO:0060548)	2.95	10	KRAS, AKT1, CASP8, PALB2, BARD1, TP53, RB1CC1, PIK3CA, ESR1, BRCA1
positive regulation of protein phosphorylation (GO:0001934)	2.95	10	ATM, NBN, KRAS, ESR1, TP53, PHB, RB1CC1, PIK3CA, AKT1, CHEK2
DNA biosynthetic process (GO:0071897)	4.89	10	PHB, ATM, BRCA2, PALB2, BARD1, XRCC3, NBN, BRCA1, BRIP1, RAD51
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	10	ATM, PHB, BRCA2, BARD1, TP53, ESR1, NBN, BRCA1, CHEK2, TSG101
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	9	PHB, ATM, BRCA2, AKT1, TP53, CDH1, ESR1, BRCA1, CHEK2
macromolecular complex subunit organization (GO:0043933)	2.14	9	PHB, ATM, BRCA2, XRCC3, CASP8, TP53, FAM175A, ESR1, RAD51
regulation of cellular component organization (GO:0051128)	2.01	9	PHB, ATM, NBN, XRCC3, CASP8, TP53, AKT1, BRCA1, TSG101
positive regulation of gene expression (GO:0010628)	2.35	9	PHB, KRAS, BRCA2, ESR1, TP53, CDH1, AKT1, BRCA1, CHEK2
cell cycle (GO:0007049)	3.14	9	ATM, NBN, BRCA2, PPM1D, TP53, RB1CC1, BRCA1, CHEK2, TSG101
response to ionizing radiation (GO:0010212)	4.74	9	ATM, BRCA2, TP53, FAM175A, XRCC3, CHEK2, BRCA1, RAD54L, RAD51
positive regulation of biosynthetic process (GO:0009891)	2.29	9	PHB, ATM, BRCA2, AKT1, TP53, CDH1, ESR1, BRCA1, CHEK2
cellular response to organic substance (GO:0071310)	2.78	9	PHB, ESR1, CASP8, PIK3CA, CDH1, AKT1, BRCA1, CHEK2, RAD51
negative regulation of apoptotic process (GO:0043066)	3.04	9	KRAS, CASP8, PALB2, BARD1, PIK3CA, RB1CC1, TP53, AKT1, BRCA1
response to organic cyclic compound (GO:0014070)	3.07	9	BRCA2, ESR1, CASP8, CDH1, KRAS, AKT1, BRCA1, CHEK2, RAD51
regulation of molecular function (GO:0065009)	1.78	9	ATM, NBN, KRAS, AKT1, CASP8, TP53, PIK3CA, ESR1, TSG101
negative regulation of programmed cell death (GO:0043069)	3.02	9	KRAS, CASP8, PALB2, BARD1, PIK3CA, RB1CC1, TP53, AKT1, BRCA1
regulation of catalytic activity (GO:0050790)	1.97	9	ATM, NBN, KRAS, AKT1, CASP8, TP53, PIK3CA, ESR1, TSG101
reproductive process (GO:0022414)	2.55	9	ATM, NBN, XRCC3, BRCA2, ESR1, CASP8, AKT1, RAD54L, RAD51
localization (GO:0051179)	1.4	9	ATM, SLC22A18, BRCA2, AKT1, TP53, CDH1, PIK3CA, ESR1, TSG101
response to oxygen-containing compound (GO:1901700)	2.57	9	BRCA2, ESR1, CASP8, PIK3CA, CDH1, AKT1, BRCA1, CHEK2, RAD51
animal organ development (GO:0048513)	2.53	9	ATM, BRCA2, AKT1, PALB2, PIK3CA, RB1CC1, CDH1, ESR1, BRCA1
chromosome organization (GO:0051276)	3.79	9	ATM, NBN, BRCA2, PALB2, XRCC3, BRCA1, BRIP1, RAD54L, RAD51
regulation of response to stress (GO:0080134)	2.53	9	PHB, ATM, CASP8, KRAS, FAM175A, AKT1, BRCA1, CHEK2, RAD51
DNA synthesis involved in DNA repair (GO:0000731)	5.42	9	ATM, NBN, BRCA2, PALB2, BARD1, XRCC3, BRCA1, BRIP1, RAD51
strand displacement (GO:0000732)	6.47	9	ATM, NBN, BRCA2, PALB2, BARD1, XRCC3, BRCA1, BRIP1, RAD51
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	9	PHB, ATM, BRCA2, AKT1, TP53, CDH1, ESR1, BRCA1, CHEK2
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	8	PHB, BRCA2, ESR1, TP53, CDH1, AKT1, BRCA1, CHEK2
negative regulation of cell proliferation (GO:0008285)	3.26	8	PHB, ATM, BRCA2, PPM1D, TP53, ESR1, BRIP1, TSG101
single-organism metabolic process (GO:0044710)	1.63	8	ATM, NBN, KRAS, NQO2, RB1CC1, PIK3CA, AKT1, BRCA1
cellular component assembly (GO:0022607)	2.14	8	CASP8, TSG101, CDH1, RB1CC1, TP53, XRCC3, CHEK2, RAD51
recombinational repair (GO:0000725)	5.37	8	ATM, NBN, BRCA2, PALB2, XRCC3, BRCA1, RAD54L, RAD51
regulation of organelle organization (GO:0033043)	2.72	8	ATM, NBN, XRCC3, CASP8, TP53, AKT1, BRCA1, TSG101
regulation of transport (GO:0051049)	2.24	8	AKT1, CASP8, BARD1, TP53, CDH1, ESR1, BRCA1, TSG101
negative regulation of response to stimulus (GO:0048585)	2.52	8	PHB, ATM, ESR1, CASP8, RB1CC1, AKT1, BRCA1, CHEK2
double-strand break repair via homologous recombination (GO:0000724)	5.38	8	ATM, NBN, BRCA2, PALB2, XRCC3, BRCA1, RAD54L, RAD51
regulation of cell cycle process (GO:0010564)	3.5	8	ATM, NBN, BRCA2, XRCC3, TP53, AKT1, BRCA1, CHEK2
positive regulation of RNA metabolic process (GO:0051254)	2.51	8	PHB, BRCA2, ESR1, TP53, CDH1, AKT1, BRCA1, CHEK2
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	8	PHB, BRCA2, ESR1, TP53, CDH1, AKT1, BRCA1, CHEK2
DNA recombination (GO:0006310)	4.39	8	ATM, NBN, BRCA2, PALB2, XRCC3, BRCA1, RAD54L, RAD51
regulation of signal transduction by p53 class mediator (GO:1901796)	4.63	8	ATM, NBN, BARD1, TP53, AKT1, BRCA1, BRIP1, CHEK2
regulation of localization (GO:0032879)	1.94	8	AKT1, CASP8, BARD1, TP53, CDH1, ESR1, BRCA1, TSG101
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	8	PHB, BRCA2, ESR1, TP53, CDH1, AKT1, BRCA1, CHEK2
negative regulation of biosynthetic process (GO:0009890)	2.47	7	PHB, BRCA2, TP53, ESR1, BRCA1, CHEK2, TSG101
anatomical structure homeostasis (GO:0060249)	4.25	7	ATM, NBN, BRCA2, BARD1, KRAS, XRCC3, RAD51
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	7	PHB, BRCA2, TP53, ESR1, BRCA1, CHEK2, TSG101
apoptotic signaling pathway (GO:0097190)	4.12	7	ATM, NBN, BRCA2, CASP8, TP53, BRCA1, CHEK2
positive regulation of signaling (GO:0023056)	2.41	7	PHB, ATM, ESR1, CASP8, TP53, KRAS, AKT1
negative regulation of signaling (GO:0023057)	2.65	7	PHB, ATM, ESR1, CASP8, RB1CC1, AKT1, BRCA1
negative regulation of gene expression (GO:0010629)	2.48	7	PHB, AKT1, BARD1, TP53, ESR1, BRCA1, TSG101
negative regulation of cell communication (GO:0010648)	2.66	7	PHB, ATM, ESR1, CASP8, RB1CC1, AKT1, BRCA1
positive regulation of cell communication (GO:0010647)	2.41	7	PHB, ATM, ESR1, CASP8, TP53, KRAS, AKT1
regulation of protein localization (GO:0032880)	2.88	7	CASP8, BARD1, TP53, CDH1, AKT1, BRCA1, TSG101
regulation of mitotic cell cycle (GO:0007346)	3.71	7	ATM, NBN, BRCA2, AKT1, TP53, XRCC3, CHEK2
negative regulation of cell cycle (GO:0045786)	3.67	7	ATM, NBN, BARD1, TP53, BRCA1, CHEK2, TSG101
positive regulation of cell cycle (GO:0045787)	3.94	7	ATM, BRCA2, XRCC3, TP53, AKT1, BRCA1, CHEK2
negative regulation of signal transduction (GO:0009968)	2.75	7	PHB, ATM, ESR1, CASP8, RB1CC1, AKT1, BRCA1
positive regulation of signal transduction (GO:0009967)	2.5	7	PHB, ATM, ESR1, CASP8, TP53, KRAS, AKT1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	7	PHB, BRCA2, TP53, ESR1, BRCA1, CHEK2, TSG101
response to external stimulus (GO:0009605)	2.55	7	BRCA2, CASP8, PPM1D, TP53, AKT1, BRCA1, BRIP1
positive regulation of cellular component organization (GO:0051130)	2.68	7	ATM, NBN, CASP8, TP53, AKT1, BRCA1, TSG101
regulation of establishment of protein localization (GO:0070201)	3.02	7	CASP8, BARD1, TP53, CDH1, AKT1, BRCA1, TSG101
establishment of localization (GO:0051234)	1.48	7	ATM, SLC22A18, BRCA2, PIK3CA, CDH1, AKT1, TSG101
cellular response to oxygen-containing compound (GO:1901701)	3.22	7	ESR1, CDH1, PIK3CA, AKT1, BRCA1, CHEK2, RAD51
DNA damage checkpoint (GO:0000077)	5.37	7	ATM, NBN, TP53, FAM175A, BRCA1, BRIP1, CHEK2
DNA integrity checkpoint (GO:0031570)	5.25	7	ATM, NBN, TP53, FAM175A, BRCA1, BRIP1, CHEK2
cell cycle checkpoint (GO:0000075)	4.79	7	ATM, NBN, TP53, FAM175A, BRCA1, BRIP1, CHEK2
cellular response to organic cyclic compound (GO:0071407)	3.93	7	ESR1, CASP8, CDH1, AKT1, BRCA1, CHEK2, RAD51
regulation of transferase activity (GO:0051338)	2.88	7	ATM, NBN, KRAS, TP53, PIK3CA, AKT1, TSG101
phosphate-containing compound metabolic process (GO:0006796)	2.16	7	ATM, PPM1D, PIK3CA, RB1CC1, KRAS, AKT1, CHEK2
phosphorus metabolic process (GO:0006793)	2.15	7	ATM, PPM1D, PIK3CA, RB1CC1, KRAS, AKT1, CHEK2
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	7	PHB, BRCA2, TP53, ESR1, BRCA1, CHEK2, TSG101
response to extracellular stimulus (GO:0009991)	3.71	6	BRCA2, PPM1D, TP53, AKT1, BRCA1, BRIP1
regulation of cellular localization (GO:0060341)	3.03	6	CASP8, BARD1, CDH1, TP53, AKT1, BRCA1
phosphorylation (GO:0016310)	2.63	6	ATM, KRAS, RB1CC1, PIK3CA, AKT1, CHEK2
cell differentiation (GO:0030154)	2.14	6	PHB, CASP8, KRAS, TP53, AKT1, TSG101
mitotic cell cycle process (GO:1903047)	3.12	6	ATM, NBN, PPM1D, TP53, CHEK2, HMMR
intrinsic apoptotic signaling pathway (GO:0097193)	4.69	6	ATM, NBN, BRCA2, TP53, BRCA1, CHEK2
regulation of cellular protein localization (GO:1903827)	3.43	6	CASP8, BARD1, CDH1, TP53, AKT1, BRCA1
regulation of mitotic cell cycle phase transition (GO:1901990)	4.23	6	ATM, NBN, AKT1, TP53, XRCC3, CHEK2
positive regulation of cell death (GO:0010942)	3.32	6	ATM, CASP8, BARD1, TP53, AKT1, CHEK2
cell death (GO:0008219)	3.05	6	ATM, CASP8, TP53, AKT1, CHEK2, BRCA1
positive regulation of establishment of protein localization (GO:1904951)	3.49	6	CASP8, CDH1, TP53, AKT1, BRCA1, TSG101
signal transduction by p53 class mediator (GO:0072331)	4.88	6	ATM, NBN, BRCA2, TP53, BRCA1, CHEK2
multicellular organism development (GO:0007275)	2.54	6	NBN, BRCA2, PALB2, TP53, AKT1, BRCA1
positive regulation of catalytic activity (GO:0043085)	2.4	6	NBN, ESR1, CASP8, KRAS, PIK3CA, AKT1
organic substance catabolic process (GO:1901575)	2.45	6	ATM, TP53, HMMR, AKT1, CHEK2, TSG101
chromatin organization (GO:0006325)	3.28	6	PHB, ATM, BRCA2, TP53, FAM175A, ESR1
positive regulation of transport (GO:0051050)	2.9	6	CASP8, CDH1, TP53, AKT1, BRCA1, TSG101
DNA damage response, signal transduction by p53 class mediator (GO:0030330)	5.3	6	ATM, NBN, BRCA2, TP53, BRCA1, CHEK2
peptidyl-amino acid modification (GO:0018193)	2.98	6	ATM, BRCA2, TP53, AKT1, CHEK2, BRCA1
positive regulation of apoptotic process (GO:0043065)	3.38	6	ATM, CASP8, BARD1, TP53, AKT1, CHEK2
regulation of immune system process (GO:0002682)	2.5	6	ATM, PHB, CASP8, KRAS, PIK3CA, AKT1
positive regulation of molecular function (GO:0044093)	2.23	6	NBN, ESR1, CASP8, KRAS, PIK3CA, AKT1
cellular localization (GO:0051641)	2.32	6	ATM, ESR1, CDH1, TP53, AKT1, TSG101
positive regulation of programmed cell death (GO:0043068)	3.38	6	ATM, CASP8, BARD1, TP53, AKT1, CHEK2
protein phosphorylation (GO:0006468)	2.89	6	ATM, KRAS, RB1CC1, PIK3CA, AKT1, CHEK2
positive regulation of DNA metabolic process (GO:0051054)	4.49	6	ATM, NBN, FAM175A, AKT1, BRCA1, RAD51
cell proliferation (GO:0008283)	3.23	6	NBN, BRCA2, ESR1, PALB2, TP53, AKT1
regulation of developmental process (GO:0050793)	2.1	6	BRCA2, ESR1, CASP8, PIK3CA, AKT1, BRCA1
apoptotic process (GO:0006915)	3.14	6	ATM, CASP8, TP53, AKT1, CHEK2, BRCA1
programmed cell death (GO:0012501)	3.1	6	ATM, CASP8, TP53, AKT1, CHEK2, BRCA1
regulation of multicellular organismal process (GO:0051239)	1.87	6	BRCA2, ESR1, CASP8, PIK3CA, AKT1, BRCA1
positive regulation of intracellular signal transduction (GO:1902533)	2.95	6	PHB, ATM, CASP8, KRAS, TP53, ESR1
regulation of neuron death (GO:1901214)	4.19	6	ATM, ESR1, KRAS, TP53, AKT1, PIK3CA
catabolic process (GO:0009056)	2.38	6	ATM, TP53, TSG101, AKT1, CHEK2, HMMR
macromolecule catabolic process (GO:0009057)	3.0	6	ATM, TP53, HMMR, AKT1, CHEK2, TSG101
signal transduction in response to DNA damage (GO:0042770)	5.15	6	ATM, NBN, BRCA2, TP53, BRCA1, CHEK2
system process (GO:0003008)	2.3	6	NBN, SLC22A18, KRAS, NQO2, AKT1, PIK3CA
RNA metabolic process (GO:0016070)	1.59	6	ATM, TP53, RB1CC1, ESR1, CHEK2, BRCA1
single organism reproductive process (GO:0044702)	2.73	6	ATM, NBN, BRCA2, ESR1, CASP8, AKT1
regulation of cell cycle phase transition (GO:1901987)	4.15	6	ATM, NBN, AKT1, TP53, XRCC3, CHEK2
negative regulation of RNA metabolic process (GO:0051253)	2.66	6	PHB, BARD1, TP53, ESR1, BRCA1, TSG101
regulation of cellular response to stress (GO:0080135)	3.4	6	ATM, FAM175A, AKT1, BRCA1, CHEK2, RAD51
positive regulation of organelle organization (GO:0010638)	3.38	6	ATM, NBN, CASP8, TP53, BRCA1, TSG101
response to nutrient levels (GO:0031667)	3.77	6	BRCA2, PPM1D, TP53, AKT1, BRCA1, BRIP1
immune system process (GO:0002376)	2.29	6	ATM, NBN, CASP8, KRAS, PIK3CA, AKT1
single-organism organelle organization (GO:1902589)	2.68	6	CASP8, KRAS, TP53, PIK3CA, CHEK2, TSG101
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	6	PHB, ESR1, TP53, AKT1, BRCA1, BRIP1
regulation of chromosome organization (GO:0033044)	4.11	5	ATM, NBN, BRCA1, TP53, XRCC3
response to gamma radiation (GO:0010332)	5.78	5	ATM, CHEK2, BRCA2, RAD51, TP53
RNA biosynthetic process (GO:0032774)	1.84	5	TP53, BRCA1, ESR1, CHEK2, RB1CC1
regulation of apoptotic signaling pathway (GO:2001233)	3.83	5	TP53, BRCA1, CASP8, RB1CC1, AKT1
meiotic cell cycle process (GO:1903046)	4.71	5	ATM, RAD54L, BRCA2, RAD51, XRCC3
membrane organization (GO:0061024)	3.04	5	CDH1, TP53, CASP8, AKT1, TSG101
negative regulation of cell cycle process (GO:0010948)	4.37	5	ATM, NBN, BRCA1, CHEK2, TP53
regulation of neuron apoptotic process (GO:0043523)	4.47	5	ATM, TP53, KRAS, ESR1, PIK3CA
regulation of protein transport (GO:0051223)	3.12	5	TP53, BRCA1, BARD1, CDH1, TSG101
mitochondrion organization (GO:0007005)	3.69	5	PHB, TP53, CASP8, AKT1, PIK3CA
regulation of MAPK cascade (GO:0043408)	3.22	5	PHB, AKT1, ESR1, KRAS, TSG101
response to endogenous stimulus (GO:0009719)	2.79	5	BRCA1, KRAS, RAD51, AKT1, CDH1
positive regulation of cell cycle process (GO:0090068)	4.25	5	ATM, BRCA1, TP53, CHEK2, XRCC3
double-strand break repair via nonhomologous end joining (GO:0006303)	5.82	5	FAM175A, ATM, BRCA1, NBN, BARD1
non-recombinational repair (GO:0000726)	5.8	5	FAM175A, ATM, BRCA1, NBN, BARD1
response to lipid (GO:0033993)	3.11	5	BRCA1, KRAS, BRCA2, CASP8, ESR1
regulation of growth (GO:0040008)	3.26	5	PHB, AKT1, TP53, TSG101, PIK3CA
regulation of kinase activity (GO:0043549)	3.07	5	NBN, KRAS, AKT1, TSG101, PIK3CA
protein modification by small protein conjugation or removal (GO:0070647)	2.95	5	AKT1, BRCA1, BARD1, TP53, TSG101
protein localization (GO:0008104)	2.36	5	TP53, TSG101, ESR1, AKT1, CDH1
protein modification by small protein conjugation (GO:0032446)	3.1	5	TP53, BRCA1, BARD1, TSG101, AKT1
positive regulation of immune system process (GO:0002684)	2.96	5	PHB, CASP8, KRAS, AKT1, PIK3CA
DNA replication (GO:0006260)	4.51	5	ATM, NBN, BRCA1, BRIP1, BARD1
nucleic acid-templated transcription (GO:0097659)	1.91	5	TP53, BRCA1, ESR1, CHEK2, RB1CC1
macromolecule localization (GO:0033036)	2.34	5	TP53, TSG101, ESR1, AKT1, CDH1
telomere maintenance (GO:0000723)	5.37	5	ATM, NBN, BRCA2, RAD51, XRCC3
cellular response to external stimulus (GO:0071496)	4.2	5	BRIP1, CASP8, PPM1D, TP53, AKT1
negative regulation of DNA metabolic process (GO:0051053)	4.98	5	ATM, NBN, CHEK2, BRCA2, TP53
negative regulation of nucleic acid-templated transcription (GO:1903507)	2.71	5	PHB, BRCA1, ESR1, TP53, TSG101
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	5	PHB, BRCA1, ESR1, TP53, TSG101
developmental process involved in reproduction (GO:0003006)	3.36	5	ATM, ESR1, BRCA2, CASP8, AKT1
positive regulation of cellular protein localization (GO:1903829)	3.85	5	CASP8, TP53, BRCA1, AKT1, CDH1
negative regulation of transcription, DNA-templated (GO:0045892)	2.75	5	PHB, BRCA1, ESR1, TP53, TSG101
negative regulation of intracellular signal transduction (GO:1902532)	3.63	5	ATM, PHB, ESR1, CASP8, AKT1
regulation of response to DNA damage stimulus (GO:2001020)	4.74	5	FAM175A, ATM, BRCA1, CHEK2, RAD51
multi-organism process (GO:0051704)	2.65	5	KRAS, CASP8, PPM1D, TP53, TSG101
cell cycle arrest (GO:0007050)	4.69	5	ATM, NBN, BARD1, TP53, TSG101
cellular response to abiotic stimulus (GO:0071214)	4.15	5	ATM, CASP8, RAD51, TP53, AKT1
aging (GO:0007568)	4.16	5	ATM, CHEK2, BRCA2, TP53, AKT1
intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630)	5.44	5	ATM, BRCA1, BRCA2, CHEK2, TP53
response to drug (GO:0042493)	3.71	5	TP53, RAD54L, RAD51, CHEK2, CDH1
telomere organization (GO:0032200)	5.33	5	ATM, NBN, BRCA2, RAD51, XRCC3
regulation of multicellular organismal development (GO:2000026)	2.31	5	BRCA1, ESR1, BRCA2, CASP8, AKT1
transcription, DNA-templated (GO:0006351)	1.91	5	CHEK2, BRCA1, ESR1, RB1CC1, TP53
negative regulation of apoptotic signaling pathway (GO:2001234)	4.42	4	BRCA1, CASP8, RB1CC1, AKT1
regulation of intracellular protein transport (GO:0033157)	3.8	4	BRCA1, BARD1, TP53, CDH1
regulation of extrinsic apoptotic signaling pathway (GO:2001236)	4.69	4	BRCA1, CASP8, RB1CC1, AKT1
negative regulation of extrinsic apoptotic signaling pathway (GO:2001237)	5.13	4	BRCA1, CASP8, RB1CC1, AKT1
developmental growth (GO:0048589)	4.05	4	NBN, PALB2, BRCA2, ESR1
positive regulation of kinase activity (GO:0033674)	3.54	4	NBN, KRAS, AKT1, PIK3CA
cellular macromolecule catabolic process (GO:0044265)	3.19	4	ATM, CHEK2, TP53, TSG101
regulation of intracellular transport (GO:0032386)	3.58	4	BRCA1, BARD1, TP53, CDH1
cell development (GO:0048468)	3.28	4	ATM, KRAS, ESR1, AKT1
regulation of catabolic process (GO:0009894)	3.52	4	PHB, CHEK2, BARD1, AKT1
negative regulation of cellular component organization (GO:0051129)	3.35	4	ATM, NBN, BRCA1, AKT1
positive regulation of immune response (GO:0050778)	3.4	4	PHB, KRAS, CASP8, PIK3CA
cellular catabolic process (GO:0044248)	2.62	4	ATM, CHEK2, TP53, TSG101
embryo development (GO:0009790)	4.2	4	NBN, BRCA1, BRCA2, PALB2
regulation of protein catabolic process (GO:0042176)	3.83	4	PHB, CHEK2, BARD1, AKT1
embryo development ending in birth or egg hatching (GO:0009792)	4.35	4	NBN, BRCA1, BRCA2, PALB2
response to light stimulus (GO:0009416)	4.08	4	KRAS, BRCA2, TP53, AKT1
cell surface receptor signaling pathway (GO:0007166)	2.09	4	KRAS, CASP8, AKT1, PIK3CA
cell communication (GO:0007154)	3.04	4	PPM1D, BRIP1, KRAS, TP53
positive regulation of protein transport (GO:0051222)	3.61	4	TP53, BRCA1, CDH1, TSG101
response to cytokine (GO:0034097)	3.84	4	PHB, BRCA1, AKT1, CASP8
macromolecular complex assembly (GO:0065003)	2.55	4	CASP8, RAD51, TP53, XRCC3
response to estradiol (GO:0032355)	4.73	4	BRCA1, BRCA2, ESR1, CASP8
single-organism biosynthetic process (GO:0044711)	2.8	4	ATM, BRCA1, AKT1, PIK3CA
intracellular receptor signaling pathway (GO:0030522)	4.6	4	PHB, BRCA1, ESR1, CASP8
growth (GO:0040007)	3.8	4	NBN, PALB2, BRCA2, ESR1
regulation of cellular component biogenesis (GO:0044087)	3.08	4	ATM, BRCA1, TP53, TSG101
DNA double-strand break processing (GO:0000729)	6.78	4	ATM, NBN, BRCA1, BARD1
nuclear division (GO:0000280)	3.85	4	RAD54L, BRCA2, CHEK2, RAD51
positive regulation of cell cycle arrest (GO:0071158)	5.29	4	ATM, BRCA1, CHEK2, TP53
negative regulation of cell cycle phase transition (GO:1901988)	4.74	4	ATM, NBN, CHEK2, TP53
negative regulation of molecular function (GO:0044092)	2.74	4	CASP8, ESR1, TP53, AKT1
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	4	BRCA1, ESR1, TP53, AKT1
chordate embryonic development (GO:0043009)	4.38	4	NBN, BRCA1, BRCA2, PALB2
regulation of cell cycle arrest (GO:0071156)	5.05	4	ATM, BRCA1, CHEK2, TP53
cellular response to endogenous stimulus (GO:0071495)	3.33	4	BRCA1, RAD51, AKT1, CDH1
negative regulation of mitotic cell cycle (GO:0045930)	4.45	4	ATM, NBN, CHEK2, TP53
transport (GO:0006810)	1.51	4	SLC22A18, AKT1, PIK3CA, TSG101
multicellular organismal reproductive process (GO:0048609)	3.35	4	ATM, BRCA2, ESR1, AKT1
regulation of protein kinase activity (GO:0045859)	3.15	4	KRAS, AKT1, PIK3CA, TSG101
regulation of reactive oxygen species metabolic process (GO:2000377)	4.71	4	BRCA1, ESR1, TP53, AKT1
establishment of protein localization (GO:0045184)	2.53	4	AKT1, BRCA2, CDH1, TSG101
cell activation (GO:0001775)	3.47	4	NBN, CASP8, AKT1, PIK3CA
regulation of cell growth (GO:0001558)	3.75	4	PHB, TP53, AKT1, TSG101
single-organism membrane organization (GO:0044802)	3.19	4	TP53, CASP8, AKT1, CDH1
negative regulation of protein metabolic process (GO:0051248)	2.82	4	PHB, BRCA1, CASP8, AKT1
positive regulation of transferase activity (GO:0051347)	3.31	4	NBN, KRAS, AKT1, PIK3CA
negative regulation of neuron death (GO:1901215)	4.57	4	KRAS, ESR1, AKT1, PIK3CA
single-organism localization (GO:1902578)	2.09	4	SLC22A18, AKT1, CDH1, PIK3CA
cell aging (GO:0007569)	5.54	4	ATM, CHEK2, BRCA2, TP53
regulation of hydrolase activity (GO:0051336)	2.53	4	CASP8, ESR1, TP53, AKT1
negative regulation of cellular protein metabolic process (GO:0032269)	2.88	4	PHB, BRCA1, AKT1, CASP8
regulation of immune response (GO:0050776)	2.98	4	PHB, KRAS, CASP8, PIK3CA
regulation of G1/S transition of mitotic cell cycle (GO:2000045)	4.81	4	ATM, CHEK2, AKT1, TP53
response to alcohol (GO:0097305)	4.58	4	BRCA1, RAD51, CASP8, CDH1
response to organonitrogen compound (GO:0010243)	3.2	4	BRCA1, RAD51, AKT1, CDH1
cellular response to nitrogen compound (GO:1901699)	3.79	4	BRCA1, RAD51, AKT1, CDH1
negative regulation of organelle organization (GO:0010639)	4.07	4	ATM, NBN, BRCA1, AKT1
cellular response to organonitrogen compound (GO:0071417)	3.87	4	CDH1, BRCA1, RAD51, AKT1
regulation of cell cycle G1/S phase transition (GO:1902806)	4.74	4	ATM, CHEK2, AKT1, TP53
protein ubiquitination (GO:0016567)	3.28	4	BRCA1, BARD1, TSG101, AKT1
regulation of nucleocytoplasmic transport (GO:0046822)	4.33	4	BRCA1, BARD1, TP53, CDH1
organelle fission (GO:0048285)	3.79	4	RAD54L, BRCA2, CHEK2, RAD51
negative regulation of mitotic cell cycle phase transition (GO:1901991)	4.82	4	ATM, NBN, CHEK2, TP53
gland development (GO:0048732)	4.15	4	RB1CC1, BRCA2, PIK3CA, CDH1
positive regulation of chromosome organization (GO:2001252)	4.76	4	ATM, NBN, BRCA1, TP53
response to nitrogen compound (GO:1901698)	3.12	4	BRCA1, RAD51, AKT1, CDH1
positive regulation of intracellular transport (GO:0032388)	4.08	3	BRCA1, TP53, CDH1
G2/M transition of mitotic cell cycle (GO:0000086)	4.84	3	CHEK2, PPM1D, HMMR
behavior (GO:0007610)	3.47	3	KRAS, NQO2, TP53
chromosome breakage (GO:0031052)	8.34	3	BRCA1, BRCA2, PALB2
small molecule metabolic process (GO:0044281)	2.38	3	BRCA1, AKT1, PIK3CA
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	3	KRAS, AKT1, PIK3CA
signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	5.59	3	ATM, CHEK2, TP53
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	3.54	3	KRAS, AKT1, PIK3CA
intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	5.59	3	ATM, CHEK2, TP53
reciprocal meiotic recombination (GO:0007131)	6.33	3	ATM, RAD51, XRCC3
regulation of defense response (GO:0031347)	3.11	3	PHB, KRAS, CASP8
hormone-mediated signaling pathway (GO:0009755)	4.66	3	PHB, BRCA1, ESR1
negative regulation of hydrolase activity (GO:0051346)	3.74	3	CASP8, TP53, AKT1
positive regulation of response to DNA damage stimulus (GO:2001022)	5.55	3	FAM175A, ATM, BRCA1
negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)	5.17	3	ATM, CHEK2, TP53
signal transduction involved in DNA damage checkpoint (GO:0072422)	5.55	3	ATM, CHEK2, TP53
response to hypoxia (GO:0001666)	4.13	3	ATM, TP53, AKT1
interspecies interaction between organisms (GO:0044419)	3.08	3	CASP8, TP53, TSG101
negative regulation of lipid metabolic process (GO:0045833)	5.33	3	BRCA1, ESR1, AKT1
(GO:1905269)	5.25	3	ATM, BRCA1, TP53
DNA geometric change (GO:0032392)	5.31	3	NBN, BRIP1, RAD51
regulation of DNA repair (GO:0006282)	5.4	3	FAM175A, BRCA1, RAD51
negative regulation of transport (GO:0051051)	3.6	3	BARD1, ESR1, AKT1
immune response-activating signal transduction (GO:0002757)	3.8	3	KRAS, CASP8, PIK3CA
regulation of proteolysis (GO:0030162)	3.2	3	PHB, AKT1, CASP8
protein catabolic process (GO:0030163)	3.93	3	CHEK2, TP53, AKT1
intracellular steroid hormone receptor signaling pathway (GO:0030518)	5.47	3	PHB, BRCA1, ESR1
peptidyl-serine modification (GO:0018209)	4.72	3	ATM, CHEK2, AKT1
signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	5.59	3	ATM, CHEK2, TP53
cellular response to extracellular stimulus (GO:0031668)	4.57	3	PPM1D, BRIP1, TP53
cellular response to nutrient levels (GO:0031669)	4.7	3	PPM1D, BRIP1, TP53
response to biotic stimulus (GO:0009607)	3.09	3	PPM1D, CASP8, TP53
peptidyl-lysine modification (GO:0018205)	3.98	3	BRCA1, BRCA2, TP53
regulation of DNA replication (GO:0006275)	5.02	3	NBN, CHEK2, BRCA2
chemical homeostasis (GO:0048878)	2.97	3	ESR1, AKT1, PIK3CA
covalent chromatin modification (GO:0016569)	3.89	3	ATM, PHB, BRCA2
DNA conformation change (GO:0071103)	4.9	3	NBN, BRIP1, RAD51
regulation of protein stability (GO:0031647)	4.33	3	PHB, CHEK2, KRAS
regulation of histone modification (GO:0031056)	4.85	3	ATM, BRCA1, TP53
reciprocal DNA recombination (GO:0035825)	6.33	3	ATM, RAD51, XRCC3
positive regulation of histone modification (GO:0031058)	5.32	3	ATM, BRCA1, TP53
regulation of protein serine/threonine kinase activity (GO:0071900)	3.58	3	KRAS, AKT1, TSG101
signal transduction involved in DNA integrity checkpoint (GO:0072401)	5.55	3	ATM, CHEK2, TP53
regulation of oxidoreductase activity (GO:0051341)	5.27	3	KRAS, ESR1, AKT1
anatomical structure morphogenesis (GO:0009653)	2.53	3	PALB2, KRAS, ESR1
G2 DNA damage checkpoint (GO:0031572)	6.26	3	FAM175A, NBN, BRCA1
immune response-regulating signaling pathway (GO:0002764)	3.72	3	KRAS, CASP8, PIK3CA
positive regulation of hydrolase activity (GO:0051345)	2.91	3	ESR1, CASP8, AKT1
protein autophosphorylation (GO:0046777)	4.46	3	ATM, CHEK2, AKT1
histone modification (GO:0016570)	3.91	3	PHB, ATM, BRCA2
response to nutrient (GO:0007584)	4.49	3	BRCA2, BRCA1, BRIP1
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	3	ATM, PALB2, PIK3CA
positive regulation of reactive oxygen species metabolic process (GO:2000379)	5.29	3	ESR1, TP53, AKT1
lipid metabolic process (GO:0006629)	2.68	3	ATM, BRCA1, PIK3CA
response to X-ray (GO:0010165)	6.33	3	BRCA2, RAD51, TP53
regulation of monooxygenase activity (GO:0032768)	5.69	3	ESR1, KRAS, AKT1
meiotic nuclear division (GO:0007126)	5.37	3	RAD54L, BRCA2, RAD51
tissue development (GO:0009888)	3.27	3	PALB2, ESR1, PIK3CA
positive regulation of MAPK cascade (GO:0043410)	3.57	3	PHB, KRAS, ESR1
cellular response to radiation (GO:0071478)	4.81	3	ATM, RAD51, TP53
mitotic cell cycle checkpoint (GO:0007093)	5.31	3	ATM, NBN, TP53
cellular protein localization (GO:0034613)	3.11	3	ESR1, TP53, CDH1
regulation of protein localization to nucleus (GO:1900180)	4.34	3	BRCA1, AKT1, CDH1
positive regulation of protein localization to nucleus (GO:1900182)	4.87	3	BRCA1, AKT1, CDH1
brain development (GO:0007420)	4.24	3	ATM, BRCA1, BRCA2
cellular response to cytokine stimulus (GO:0071345)	4.33	3	PHB, BRCA1, AKT1
response to decreased oxygen levels (GO:0036293)	4.09	3	ATM, TP53, AKT1
negative regulation of protein modification process (GO:0031400)	3.4	3	PHB, BRCA1, AKT1
cellular macromolecule localization (GO:0070727)	3.1	3	ESR1, TP53, CDH1
regulation of leukocyte activation (GO:0002694)	3.6	3	ATM, AKT1, PIK3CA
positive regulation of nucleocytoplasmic transport (GO:0046824)	4.93	3	BRCA1, TP53, CDH1
regulation of cell cycle checkpoint (GO:1901976)	6.36	3	CHEK2, XRCC3, AKT1
cellular response to alcohol (GO:0097306)	6.07	3	BRCA1, RAD51, CDH1
positive regulation of monooxygenase activity (GO:0032770)	6.47	3	KRAS, ESR1, AKT1
regulation of cell adhesion (GO:0030155)	3.27	3	AKT1, CDH1, PIK3CA
establishment of localization in cell (GO:0051649)	2.47	3	ATM, AKT1, TSG101
response to UV (GO:0009411)	4.88	3	BRCA2, TP53, AKT1
positive regulation of nitric-oxide synthase activity (GO:0051000)	6.78	3	ESR1, KRAS, AKT1
ERBB signaling pathway (GO:0038127)	5.36	3	KRAS, AKT1, PIK3CA
steroid hormone mediated signaling pathway (GO:0043401)	4.9	3	PHB, BRCA1, ESR1
ERBB2 signaling pathway (GO:0038128)	6.09	3	AKT1, KRAS, PIK3CA
regulation of DNA-dependent DNA replication (GO:0090329)	5.97	3	NBN, CHEK2, BRCA2
negative regulation of catalytic activity (GO:0043086)	3.0	3	CASP8, TP53, AKT1
telomere maintenance via recombination (GO:0000722)	6.26	3	BRCA2, RAD51, XRCC3
cellular response to ionizing radiation (GO:0071479)	5.78	3	ATM, RAD51, TP53
regulation of lymphocyte activation (GO:0051249)	3.73	3	ATM, PIK3CA, AKT1
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	3.12	3	PHB, ESR1, TP53
positive regulation of multicellular organismal process (GO:0051240)	2.49	3	BRCA1, CASP8, AKT1
proteolysis (GO:0006508)	2.73	3	CASP8, TP53, TSG101
response to oxygen levels (GO:0070482)	4.02	3	ATM, TP53, AKT1
positive regulation of cell proliferation (GO:0008284)	3.01	3	KRAS, ESR1, AKT1
reproductive structure development (GO:0048608)	4.08	3	BRCA2, ESR1, AKT1
proteolysis involved in cellular protein catabolic process (GO:0051603)	3.59	3	CASP8, TP53, TSG101
neurological system process (GO:0050877)	2.64	3	NBN, KRAS, NQO2
DNA duplex unwinding (GO:0032508)	5.37	3	NBN, BRIP1, RAD51
regulation of cell differentiation (GO:0045595)	2.42	3	KRAS, CASP8, AKT1
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:0006977)	5.6	3	ATM, CHEK2, TP53
cellular lipid metabolic process (GO:0044255)	2.92	3	ATM, BRCA1, PIK3CA
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator (GO:0006978)	7.09	3	BRCA1, BRCA2, TP53
protein oligomerization (GO:0051259)	3.71	3	RAD51, CASP8, TP53
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091)	4.29	3	KRAS, ESR1, AKT1
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090)	3.83	3	KRAS, ESR1, AKT1
regulation of epithelial cell proliferation (GO:0050678)	4.06	3	BRCA2, ESR1, AKT1
positive regulation of proteolysis (GO:0045862)	3.86	3	PHB, CASP8, AKT1
positive regulation of protein kinase activity (GO:0045860)	3.61	3	KRAS, PIK3CA, AKT1
regulation of chromatin organization (GO:1902275)	4.69	3	ATM, BRCA1, TP53
response to inorganic substance (GO:0010035)	3.56	3	RAD51, CASP8, CDH1
peptidyl-serine phosphorylation (GO:0018105)	4.82	3	ATM, CHEK2, AKT1
cell cycle G2/M phase transition (GO:0044839)	4.82	3	CHEK2, PPM1D, HMMR
regulation of cell activation (GO:0050865)	3.53	3	ATM, AKT1, PIK3CA
signal transduction involved in cell cycle checkpoint (GO:0072395)	5.54	3	ATM, CHEK2, TP53
cell cycle phase transition (GO:0044770)	4.24	3	CHEK2, PPM1D, HMMR
regulation of cell-cell adhesion (GO:0022407)	3.79	3	AKT1, PIK3CA, CDH1
mitotic cell cycle phase transition (GO:0044772)	4.27	3	CHEK2, PPM1D, HMMR
regulation of mitochondrion organization (GO:0010821)	4.34	3	CASP8, TP53, AKT1
signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	5.59	3	ATM, CHEK2, TP53
protein complex subunit organization (GO:0071822)	2.6	3	RAD51, CASP8, TP53
organic substance transport (GO:0071702)	2.15	3	SLC22A18, AKT1, TSG101
positive regulation of oxidoreductase activity (GO:0051353)	5.94	3	KRAS, ESR1, AKT1
regulation of autophagy (GO:0010506)	4.21	3	ATM, RB1CC1, AKT1
viral process (GO:0016032)	3.15	3	CASP8, TP53, TSG101
regulation of lipid metabolic process (GO:0019216)	4.08	3	BRCA1, ESR1, AKT1
autophagy (GO:0006914)	3.82	3	RB1CC1, PIK3CA, TSG101
protein complex assembly (GO:0006461)	2.78	3	RAD51, CASP8, TP53
positive regulation of intracellular protein transport (GO:0090316)	4.19	3	BRCA1, TP53, CDH1
single-organism transport (GO:0044765)	2.18	3	SLC22A18, AKT1, PIK3CA
multi-organism cellular process (GO:0044764)	3.14	3	CASP8, TP53, TSG101
cellular component disassembly (GO:0022411)	3.52	3	CASP8, PIK3CA, CDH1
cellular process involved in reproduction in multicellular organism (GO:0022412)	4.3	3	ATM, BRCA2, AKT1
determination of adult lifespan (GO:0008340)	7.09	3	ATM, RAD54L, TP53
organelle assembly (GO:0070925)	3.75	3	RB1CC1, CHEK2, TSG101
DNA damage response, signal transduction resulting in transcription (GO:0042772)	7.02	3	BRCA1, BRCA2, TP53
lipid biosynthetic process (GO:0008610)	3.49	3	ATM, BRCA1, PIK3CA
regulation of nitric-oxide synthase activity (GO:0050999)	5.9	3	ESR1, KRAS, AKT1
mitotic recombination (GO:0006312)	6.04	3	BRCA2, RAD51, XRCC3
signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	5.59	3	ATM, CHEK2, TP53
replicative senescence (GO:0090399)	7.24	3	ATM, CHEK2, TP53
negative regulation of cell cycle G1/S phase transition (GO:1902807)	5.14	3	ATM, CHEK2, TP53
regulation of cell cycle G2/M phase transition (GO:1902749)	5.63	3	ATM, NBN, TP53
activation of immune response (GO:0002253)	3.67	3	KRAS, CASP8, PIK3CA
symbiosis, encompassing mutualism through parasitism (GO:0044403)	3.15	3	CASP8, TP53, TSG101
negative regulation of chromosome organization (GO:2001251)	5.17	3	ATM, NBN, BRCA1
positive regulation of cellular component biogenesis (GO:0044089)	3.71	3	ATM, TP53, TSG101
positive regulation of apoptotic signaling pathway (GO:2001235)	4.58	2	CASP8, TP53
negative regulation of transferase activity (GO:0051348)	3.87	2	TP53, AKT1
response to metal ion (GO:0010038)	3.91	2	CASP8, CDH1
tissue homeostasis (GO:0001894)	4.78	2	BARD1, KRAS
positive regulation of homeostatic process (GO:0032846)	4.38	2	ATM, NBN
negative regulation of homeostatic process (GO:0032845)	4.91	2	ATM, NBN
regulation of homeostatic process (GO:0032844)	3.65	2	ATM, NBN
positive regulation of defense response (GO:0031349)	3.83	2	KRAS, CASP8
positive regulation of mitochondrion organization (GO:0010822)	4.61	2	CASP8, TP53
plasma membrane organization (GO:0007009)	4.8	2	AKT1, CDH1
regulation of mitotic sister chromatid segregation (GO:0033047)	5.78	2	ATM, XRCC3
negative regulation of neuron apoptotic process (GO:0043524)	4.82	2	KRAS, PIK3CA
positive regulation of neuron apoptotic process (GO:0043525)	5.88	2	ATM, TP53
multicellular organism growth (GO:0035264)	5.37	2	PALB2, BRCA2
regulation of mitotic sister chromatid separation (GO:0010965)	5.9	2	ATM, XRCC3
regulation of leukocyte cell-cell adhesion (GO:1903037)	4.01	2	PIK3CA, AKT1
mitochondrial membrane organization (GO:0007006)	5.2	2	CASP8, TP53
signal transduction by protein phosphorylation (GO:0023014)	3.79	2	RB1CC1, KRAS
protein sumoylation (GO:0016925)	4.98	2	BRCA1, TP53
response to indole-3-methanol (GO:0071680)	8.12	2	BRCA1, CDH1
cellular response to indole-3-methanol (GO:0071681)	8.12	2	BRCA1, CDH1
response to external biotic stimulus (GO:0043207)	3.13	2	PPM1D, CASP8
positive regulation of cell adhesion (GO:0045785)	3.79	2	PIK3CA, AKT1
posttranscriptional regulation of gene expression (GO:0010608)	3.64	2	ESR1, AKT1
regulation of intrinsic apoptotic signaling pathway (GO:2001242)	4.74	2	TP53, AKT1
regulation of cytoskeleton organization (GO:0051493)	3.72	2	BRCA1, XRCC3
cellular response to hypoxia (GO:0071456)	5.11	2	TP53, AKT1
response to mechanical stimulus (GO:0009612)	4.41	2	CASP8, AKT1
Ras protein signal transduction (GO:0007265)	4.76	2	KRAS, TP53
rhythmic process (GO:0048511)	4.02	2	ESR1, TP53
negative regulation of peptidase activity (GO:0010466)	4.22	2	CASP8, AKT1
oxidation-reduction process (GO:0055114)	2.91	2	NQO2, AKT1
regulation of protein export from nucleus (GO:0046825)	6.23	2	BARD1, TP53
epithelial cell differentiation (GO:0030855)	3.98	2	AKT1, TSG101
negative regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043124)	5.78	2	ESR1, CASP8
phosphatidylinositol biosynthetic process (GO:0006661)	4.94	2	ATM, PIK3CA
regulation of mitotic nuclear division (GO:0007088)	4.83	2	ATM, XRCC3
replication fork processing (GO:0031297)	6.68	2	BRCA2, RAD51
innate immune response-activating signal transduction (GO:0002758)	4.45	2	KRAS, CASP8
T cell costimulation (GO:0031295)	5.35	2	PIK3CA, AKT1
lymphocyte costimulation (GO:0031294)	5.33	2	PIK3CA, AKT1
cellular homeostasis (GO:0019725)	3.23	2	ESR1, PIK3CA
negative regulation of intracellular steroid hormone receptor signaling pathway (GO:0033144)	6.29	2	PHB, BRCA1
hyaluronan metabolic process (GO:0030212)	6.29	2	AKT1, HMMR
regulation of intracellular steroid hormone receptor signaling pathway (GO:0033143)	5.62	2	PHB, BRCA1
cell differentiation involved in embryonic placenta development (GO:0060706)	6.59	2	CASP8, AKT1
centrosome organization (GO:0051297)	5.38	2	BRCA1, BRCA2
protein-DNA complex assembly (GO:0065004)	4.6	2	RAD51, XRCC3
nucleotide-excision repair (GO:0006289)	5.05	2	BRCA2, TP53
germ cell development (GO:0007281)	4.75	2	ATM, AKT1
negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	6.59	2	ATM, NBN
regulation of cell size (GO:0008361)	5.42	2	RB1CC1, AKT1
immune response-activating cell surface receptor signaling pathway (GO:0002429)	4.06	2	KRAS, PIK3CA
epidermal growth factor receptor signaling pathway (GO:0007173)	5.72	2	KRAS, PIK3CA
regionalization (GO:0003002)	4.24	2	ATM, PALB2
branching morphogenesis of an epithelial tube (GO:0048754)	4.93	2	ESR1, KRAS
glycerolipid metabolic process (GO:0046486)	3.91	2	ATM, PIK3CA
somitogenesis (GO:0001756)	5.9	2	ATM, PALB2
regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	5.9	2	ATM, XRCC3
platelet activation (GO:0030168)	4.96	2	AKT1, PIK3CA
negative regulation of phosphorylation (GO:0042326)	3.7	2	PHB, AKT1
organonitrogen compound metabolic process (GO:1901564)	2.32	2	AKT1, HMMR
cell division (GO:0051301)	3.68	2	CHEK2, TSG101
single-organism behavior (GO:0044708)	3.79	2	KRAS, NQO2
cell motility (GO:0048870)	3.02	2	KRAS, PIK3CA
positive regulation of nitric oxide biosynthetic process (GO:0045429)	5.99	2	ESR1, AKT1
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (GO:1901028)	5.94	2	CASP8, TP53
regulation of nuclear division (GO:0051783)	4.67	2	ATM, XRCC3
response to hormone (GO:0009725)	3.33	2	KRAS, AKT1
regulation of protein import (GO:1904589)	4.52	2	BRCA1, CDH1
carbohydrate metabolic process (GO:0005975)	3.26	2	AKT1, PIK3CA
regulation of microtubule cytoskeleton organization (GO:0070507)	4.98	2	BRCA1, XRCC3
somatic cell DNA recombination (GO:0016444)	6.23	2	ATM, NBN
regulation of cellular component size (GO:0032535)	4.21	2	RB1CC1, AKT1
glycerophospholipid biosynthetic process (GO:0046474)	4.62	2	ATM, PIK3CA
positive regulation of catabolic process (GO:0009896)	3.94	2	BARD1, AKT1
negative regulation of catabolic process (GO:0009895)	4.81	2	PHB, AKT1
response to glycoside (GO:1903416)	7.94	2	CHEK2, RAD51
regulation of protein targeting (GO:1903533)	4.0	2	BRCA1, CDH1
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	2	BRCA1, ESR1
embryonic organ development (GO:0048568)	4.86	2	PALB2, AKT1
cellular response to mechanical stimulus (GO:0071260)	5.33	2	CASP8, AKT1
movement of cell or subcellular component (GO:0006928)	2.61	2	KRAS, PIK3CA
protein stabilization (GO:0050821)	4.86	2	PHB, CHEK2
leukocyte activation (GO:0045321)	3.76	2	NBN, CASP8
morphogenesis of a branching structure (GO:0001763)	4.71	2	KRAS, ESR1
regulation of membrane permeability (GO:0090559)	5.48	2	CASP8, TP53
regulation of glucose import (GO:0046324)	5.63	2	ESR1, AKT1
regulation of DNA methylation (GO:0044030)	6.78	2	BRCA1, PIK3CA
positive regulation of ERBB signaling pathway (GO:1901186)	6.15	2	ESR1, AKT1
positive regulation of protein serine/threonine kinase activity (GO:0071902)	4.06	2	KRAS, AKT1
regulation of ERBB signaling pathway (GO:1901184)	5.3	2	ESR1, AKT1
regulation of mitotic metaphase/anaphase transition (GO:0030071)	5.92	2	ATM, XRCC3
intrinsic apoptotic signaling pathway by p53 class mediator (GO:0072332)	5.76	2	BRCA2, TP53
immune response-regulating cell surface receptor signaling pathway (GO:0002768)	3.96	2	KRAS, PIK3CA
negative regulation of phosphate metabolic process (GO:0045936)	3.45	2	PHB, AKT1
gonad development (GO:0008406)	4.92	2	BRCA2, ESR1
regulation of anatomical structure size (GO:0090066)	3.78	2	RB1CC1, AKT1
mitotic recombination-dependent replication fork processing (GO:1990426)	9.04	2	BRCA2, RAD51
cellular response to oxygen levels (GO:0071453)	4.97	2	TP53, AKT1
cell projection organization (GO:0030030)	3.14	2	AKT1, CDH1
transcription from RNA polymerase II promoter (GO:0006366)	3.38	2	ESR1, TP53
somatic diversification of immune receptors (GO:0002200)	5.92	2	ATM, NBN
cell migration (GO:0016477)	3.12	2	KRAS, PIK3CA
G-protein coupled receptor signaling pathway (GO:0007186)	2.64	2	ESR1, AKT1
regulation of telomerase activity (GO:0051972)	5.97	2	ATM, TP53
single organism cell adhesion (GO:0098602)	3.63	2	CASP8, CDH1
regulation of release of cytochrome c from mitochondria (GO:0090199)	5.94	2	TP53, AKT1
cell-cell adhesion (GO:0098609)	3.34	2	CASP8, CDH1
regulation of DNA biosynthetic process (GO:2000278)	5.17	2	ATM, TP53
hexose metabolic process (GO:0019318)	4.64	2	AKT1, PIK3CA
organophosphate metabolic process (GO:0019637)	3.04	2	ATM, PIK3CA
negative regulation of DNA replication (GO:0008156)	6.17	2	CHEK2, BRCA2
meiosis I (GO:0007127)	6.47	2	BRCA2, RAD51
cellular response to starvation (GO:0009267)	4.98	2	PPM1D, TP53
response to temperature stimulus (GO:0009266)	4.71	2	CASP8, AKT1
single-organism carbohydrate metabolic process (GO:0044723)	3.42	2	PIK3CA, AKT1
strand invasion (GO:0042148)	7.78	2	RAD51, XRCC3
organophosphate biosynthetic process (GO:0090407)	3.67	2	ATM, PIK3CA
glucose metabolic process (GO:0006006)	4.94	2	PIK3CA, AKT1
inositol lipid-mediated signaling (GO:0048017)	4.91	2	PIK3CA, AKT1
regulation of mitochondrial membrane permeability (GO:0046902)	5.55	2	CASP8, TP53
chromosome organization involved in meiotic cell cycle (GO:0070192)	5.9	2	ATM, RAD51
intracellular transport (GO:0046907)	2.67	2	AKT1, TSG101
phospholipid biosynthetic process (GO:0008654)	4.39	2	ATM, PIK3CA
positive regulation of leukocyte activation (GO:0002696)	4.0	2	PIK3CA, AKT1
protein kinase B signaling (GO:0043491)	6.2	2	AKT1, PIK3CA
liver development (GO:0001889)	4.98	2	RB1CC1, PIK3CA
cognition (GO:0050890)	4.2	2	KRAS, NQO2
cellular response to decreased oxygen levels (GO:0036294)	5.05	2	TP53, AKT1
DNA strand renaturation (GO:0000733)	7.53	2	RAD54L, TP53
positive regulation of protein catabolic process (GO:0045732)	4.18	2	BARD1, AKT1
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway (GO:1900740)	6.33	2	CASP8, TP53
aminoglycan metabolic process (GO:0006022)	4.62	2	AKT1, HMMR
positive regulation of DNA repair (GO:0045739)	6.09	2	FAM175A, BRCA1
muscle cell differentiation (GO:0042692)	5.09	2	KRAS, AKT1
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042)	6.2	2	BRCA1, CASP8
regulation of sister chromatid segregation (GO:0033045)	5.63	2	ATM, XRCC3
regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902041)	5.72	2	BRCA1, CASP8
cellular response to gamma radiation (GO:0071480)	6.78	2	ATM, RAD51
MAPK cascade (GO:0000165)	3.91	2	RB1CC1, KRAS
regulation of fibroblast proliferation (GO:0048145)	5.32	2	ESR1, TP53
cellular response to inorganic substance (GO:0071241)	4.67	2	RAD51, CDH1
regulation of anoikis (GO:2000209)	6.55	2	CHEK2, PIK3CA
positive regulation of protein import into nucleus (GO:0042307)	5.11	2	BRCA1, CDH1
regulation of MAP kinase activity (GO:0043405)	3.95	2	KRAS, TSG101
regulation of nitric oxide biosynthetic process (GO:0045428)	5.76	2	ESR1, AKT1
response to antibiotic (GO:0046677)	5.86	2	CASP8, TP53
morphogenesis of a branching epithelium (GO:0061138)	4.77	2	KRAS, ESR1
gamete generation (GO:0007276)	3.61	2	ATM, BRCA2
ubiquitin-dependent protein catabolic process (GO:0006511)	3.72	2	TP53, TSG101
regulation of microtubule-based process (GO:0032886)	4.79	2	BRCA1, XRCC3
regulation of protein import into nucleus (GO:0042306)	4.54	2	BRCA1, CDH1
protein polyubiquitination (GO:0000209)	4.23	2	BRCA1, BARD1
negative regulation of MAPK cascade (GO:0043409)	4.74	2	PHB, AKT1
glycosaminoglycan metabolic process (GO:0030203)	4.67	2	AKT1, HMMR
in utero embryonic development (GO:0001701)	4.4	2	NBN, PALB2
negative regulation of endopeptidase activity (GO:0010951)	4.26	2	CASP8, AKT1
phosphatidylinositol-mediated signaling (GO:0048015)	4.93	2	AKT1, PIK3CA
negative regulation of phosphorus metabolic process (GO:0010563)	3.45	2	PHB, AKT1
cell adhesion (GO:0007155)	2.82	2	CASP8, CDH1
regulation of cellular ketone metabolic process (GO:0010565)	4.67	2	BRCA1, AKT1
positive regulation of leukocyte cell-cell adhesion (GO:1903039)	4.35	2	AKT1, PIK3CA
positive regulation of protein import (GO:1904591)	5.08	2	BRCA1, CDH1
positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)	6.17	2	ESR1, AKT1
positive regulation of nitric oxide metabolic process (GO:1904407)	5.99	2	ESR1, AKT1
biological adhesion (GO:0022610)	2.81	2	CASP8, CDH1
regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway (GO:1900739)	6.33	2	CASP8, TP53
locomotion (GO:0040011)	2.91	2	KRAS, PIK3CA
phospholipid metabolic process (GO:0006644)	3.88	2	ATM, PIK3CA
microtubule organizing center organization (GO:0031023)	5.26	2	BRCA1, BRCA2
tube morphogenesis (GO:0035239)	4.35	2	KRAS, ESR1
somatic diversification of immune receptors via germline recombination within a single locus (GO:0002562)	6.23	2	ATM, NBN
establishment of protein localization to organelle (GO:0072594)	3.92	2	BRCA2, AKT1
modification-dependent protein catabolic process (GO:0019941)	3.71	2	TP53, TSG101
positive regulation of T cell activation (GO:0050870)	4.39	2	AKT1, PIK3CA
B cell activation (GO:0042113)	4.84	2	NBN, CASP8
positive regulation of cell differentiation (GO:0045597)	3.01	2	CASP8, AKT1
DNA damage induced protein phosphorylation (GO:0006975)	7.65	2	ATM, CHEK2
regulation of centrosome cycle (GO:0046605)	6.02	2	BRCA1, XRCC3
telomere maintenance via telomere lengthening (GO:0010833)	6.64	2	ATM, RAD51
Fc-epsilon receptor signaling pathway (GO:0038095)	4.84	2	KRAS, PIK3CA
regulation of endopeptidase activity (GO:0052548)	3.8	2	CASP8, AKT1
cellular chemical homeostasis (GO:0055082)	3.4	2	ESR1, PIK3CA
regulation of phosphatidylinositol 3-kinase signaling (GO:0014066)	4.79	2	PIK3CA, AKT1
single organismal cell-cell adhesion (GO:0016337)	3.69	2	CASP8, CDH1
regulation of chromosome segregation (GO:0051983)	5.38	2	ATM, XRCC3
anterior/posterior pattern specification (GO:0009952)	4.71	2	ATM, PALB2
vacuole organization (GO:0007033)	4.67	2	RB1CC1, TSG101
positive regulation of epithelial cell proliferation (GO:0050679)	4.67	2	ESR1, AKT1
positive regulation of developmental process (GO:0051094)	2.77	2	BRCA1, CASP8
positive regulation of lymphocyte activation (GO:0051251)	4.07	2	AKT1, PIK3CA
monosaccharide metabolic process (GO:0005996)	4.57	2	AKT1, PIK3CA
carbohydrate derivative metabolic process (GO:1901135)	3.07	2	AKT1, HMMR
regulation of glucose transport (GO:0010827)	5.12	2	ESR1, AKT1
negative regulation of cell growth (GO:0030308)	4.58	2	PHB, TP53
cellular response to drug (GO:0035690)	5.48	2	CHEK2, TP53
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122)	4.27	2	ESR1, CASP8
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (GO:1901030)	6.12	2	CASP8, TP53
regulation of telomere maintenance (GO:0032204)	5.54	2	ATM, NBN
system development (GO:0048731)	2.92	2	PIK3CA, AKT1
negative regulation of proteolysis (GO:0045861)	3.98	2	CASP8, AKT1
positive regulation of ERK1 and ERK2 cascade (GO:0070374)	4.56	2	PHB, ESR1
regulation of ERK1 and ERK2 cascade (GO:0070372)	4.23	2	PHB, ESR1
negative regulation of fatty acid metabolic process (GO:0045922)	6.33	2	BRCA1, AKT1
positive regulation of telomere maintenance (GO:0032206)	5.9	2	ATM, NBN
negative regulation of growth (GO:0045926)	4.24	2	PHB, TP53
glycerophospholipid metabolic process (GO:0006650)	4.13	2	ATM, PIK3CA
execution phase of apoptosis (GO:0097194)	6.96	2	CASP8, AKT1
regulation of peptidyl-serine phosphorylation (GO:0033135)	4.98	2	AKT1, PIK3CA
positive regulation of cell activation (GO:0050867)	3.97	2	AKT1, PIK3CA
striated muscle cell differentiation (GO:0051146)	5.69	2	KRAS, AKT1
macroautophagy (GO:0016236)	4.3	2	RB1CC1, PIK3CA
insulin receptor signaling pathway (GO:0008286)	5.33	2	PIK3CA, AKT1
regulation of T cell activation (GO:0050863)	4.05	2	PIK3CA, AKT1
mucopolysaccharide metabolic process (GO:1903510)	5.05	2	AKT1, HMMR
glucose homeostasis (GO:0042593)	4.6	2	PIK3CA, AKT1
leukocyte migration (GO:0050900)	4.19	2	KRAS, PIK3CA
Fc receptor signaling pathway (GO:0038093)	4.45	2	KRAS, PIK3CA
mitotic DNA integrity checkpoint (GO:0044774)	6.04	2	NBN, TP53
DNA recombinase assembly (GO:0000730)	7.53	2	RAD51, XRCC3
response to starvation (GO:0042594)	4.69	2	PPM1D, TP53
regulation of lipid biosynthetic process (GO:0046890)	4.87	2	BRCA1, AKT1
learning or memory (GO:0007611)	4.33	2	KRAS, NQO2
maternal process involved in female pregnancy (GO:0060135)	6.02	2	ESR1, AKT1
modification-dependent macromolecule catabolic process (GO:0043632)	3.69	2	TP53, TSG101
segmentation (GO:0035282)	5.8	2	ATM, PALB2
osteoblast differentiation (GO:0001649)	5.05	2	PHB, AKT1
positive regulation of cell-cell adhesion (GO:0022409)	4.23	2	AKT1, PIK3CA
protein-DNA complex subunit organization (GO:0071824)	4.45	2	RAD51, XRCC3
glycerolipid biosynthetic process (GO:0045017)	4.53	2	ATM, PIK3CA
regulation of generation of precursor metabolites and energy (GO:0043467)	5.24	2	AKT1, PIK3CA
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043154)	5.29	2	CASP8, AKT1
regulation of cysteine-type endopeptidase activity (GO:2000116)	4.37	2	CASP8, AKT1
negative regulation of cysteine-type endopeptidase activity (GO:2000117)	5.25	2	CASP8, AKT1
response to toxic substance (GO:0009636)	4.88	2	RAD51, CDH1
carbohydrate homeostasis (GO:0033500)	4.6	2	PIK3CA, AKT1
lymphocyte activation (GO:0046649)	3.96	2	NBN, CASP8
positive regulation of reactive oxygen species biosynthetic process (GO:1903428)	5.86	2	ESR1, AKT1
regulation of epidermal growth factor receptor signaling pathway (GO:0042058)	5.33	2	ESR1, AKT1
regulation of organelle assembly (GO:1902115)	4.7	2	BRCA1, TSG101
tissue morphogenesis (GO:0048729)	3.87	2	KRAS, ESR1
activation of innate immune response (GO:0002218)	4.41	2	KRAS, CASP8
mitotic DNA damage checkpoint (GO:0044773)	6.2	2	NBN, TP53
regulation of reactive oxygen species biosynthetic process (GO:1903426)	5.55	2	ESR1, AKT1
negative regulation of cell cycle G2/M phase transition (GO:1902750)	6.51	2	ATM, NBN
positive regulation of mitotic cell cycle (GO:0045931)	4.98	2	BRCA2, XRCC3
positive regulation of establishment of protein localization to mitochondrion (GO:1903749)	4.98	2	CASP8, TP53
positive regulation of innate immune response (GO:0045089)	4.22	2	KRAS, CASP8
regulation of innate immune response (GO:0045088)	3.86	2	KRAS, CASP8
regulation of fatty acid metabolic process (GO:0019217)	5.25	2	BRCA1, AKT1
morphogenesis of an epithelium (GO:0002009)	4.08	2	KRAS, ESR1
negative regulation of telomere capping (GO:1904354)	8.12	2	ATM, NBN
response to tumor necrosis factor (GO:0034612)	4.93	2	BRCA1, CASP8
regulation of telomere capping (GO:1904353)	6.64	2	ATM, NBN
regulation of centrosome duplication (GO:0010824)	6.23	2	BRCA1, XRCC3
regulation of translation (GO:0006417)	3.96	2	ESR1, AKT1
positive regulation of neuron death (GO:1901216)	5.52	2	ATM, TP53
phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	5.84	2	ATM, PIK3CA
response to estrogen (GO:0043627)	5.25	2	BRCA1, ESR1
positive regulation of peptidyl-serine phosphorylation (GO:0033138)	5.26	2	PIK3CA, AKT1
small GTPase mediated signal transduction (GO:0007264)	3.85	2	KRAS, TP53
regulation of G2/M transition of mitotic cell cycle (GO:0010389)	5.76	2	ATM, NBN
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)	6.33	2	BRCA2, TP53
DNA-dependent DNA replication maintenance of fidelity (GO:0045005)	6.55	2	BRCA2, RAD51
heart development (GO:0007507)	4.24	2	ATM, RB1CC1
cellular macromolecular complex assembly (GO:0034622)	3.18	2	RAD51, XRCC3
cytoskeleton organization (GO:0007010)	3.22	2	CHEK2, KRAS
regulation of establishment of protein localization to mitochondrion (GO:1903747)	4.88	2	CASP8, TP53
negative regulation of telomere maintenance (GO:0032205)	6.47	2	ATM, NBN
negative regulation of DNA-dependent DNA replication (GO:2000104)	6.96	2	CHEK2, BRCA2
inner cell mass cell proliferation (GO:0001833)	7.33	2	PALB2, BRCA2
pattern specification process (GO:0007389)	3.79	2	ATM, PALB2
response to ketone (GO:1901654)	4.53	2	CHEK2, AKT1
regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281)	4.43	2	CASP8, AKT1
protein K6-linked ubiquitination (GO:0085020)	7.65	2	BRCA1, BARD1
regulation of peptidase activity (GO:0052547)	3.75	2	CASP8, AKT1
immune effector process (GO:0002252)	3.58	2	NBN, PIK3CA
protein transport (GO:0015031)	2.62	2	AKT1, TSG101
phosphatidylinositol metabolic process (GO:0046488)	4.46	2	ATM, PIK3CA
negative regulation of protein phosphorylation (GO:0001933)	3.79	2	PHB, AKT1
regulation of cellular amide metabolic process (GO:0034248)	3.88	2	ESR1, AKT1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
regulation of intracellular protein transport (GO:0033157)	-	3.8	0.004	AKT1, CASP8, BARD1, TP53, CDH1, PIK3CA, ESR1, BRCA1, TSG101
organophosphate catabolic process (GO:0046434)	NEW	5.03	0.002	ATM, PHB, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRIP1, RAD51
positive regulation of secretion (GO:0051047)	NEW	3.85	0.02	ATM, KRAS, ESR1, TP53, CDH1, PIK3CA, AKT1, CHEK2, HMMR
protein acylation (GO:0043543)	NEW	4.65	0.038	BRCA2, ESR1, TP53, AKT1, CHEK2, TSG101
regulation of protein import into nucleus, translocation (GO:0033158)	NEW	6.68	0.045	ESR1, TP53, AKT1
nucleotide catabolic process (GO:0009166)	NEW	5.67	0.006	ATM, PHB, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
purine ribonucleoside monophosphate metabolic process (GO:0009167)	NEW	4.7	0.003	PHB, ATM, XRCC3, BRCA2, AKT1, TP53, ESR1, BRCA1, BRIP1, RAD51
nucleoside catabolic process (GO:0009164)	NEW	6.17	0.005	ATM, PHB, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
ribonucleoside monophosphate metabolic process (GO:0009161)	NEW	4.62	0.005	PHB, ATM, XRCC3, BRCA2, AKT1, TP53, ESR1, BRCA1, BRIP1, RAD51
purine ribonucleoside monophosphate catabolic process (GO:0009169)	NEW	8.12	0.005	PHB, ATM, BRCA2, XRCC3, TP53, ESR1, BRCA1, BRIP1, RAD51
cellular response to stimulus (GO:0051716)	-	1.97	0.001	ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, PALB2, CDH1, BARD1, TP53, PHB, FAM175A, RB1CC1, PIK3CA, ESR1, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
double-strand break repair (GO:0006302)	-	4.73	0.0	ATM, NBN, BRCA2, PALB2, TP53, FAM175A, XRCC3, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
signal transduction involved in DNA damage checkpoint (GO:0072422)	-	5.55	0.038	ATM, CHEK2, ESR1, TP53
regulation of apoptotic signaling pathway (GO:2001233)	-	3.83	0.0	PHB, KRAS, AKT1, CASP8, RAD51, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, HMMR
MAPK cascade (GO:0000165)	-	3.91	0.0	ATM, KRAS, AKT1, CASP8, TP53, RB1CC1, PIK3CA, ESR1, BRCA1
ribonucleoside triphosphate metabolic process (GO:0009199)	NEW	4.77	0.007	ATM, PHB, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
regulation of mitosis (GO:0007088)	-	4.83	0.017	ATM, PPM1D, CDH1, TP53, AKT1, TSG101
regulation of DNA repair (GO:0006282)	-	5.4	0.0	ESR1, TP53, FAM175A, AKT1, BRCA1, RAD51
DNA repair (GO:0006281)	-	3.59	0.0	ATM, NBN, XRCC3, BRCA2, AKT1, PALB2, BARD1, TP53, FAM175A, ESR1, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
internal protein amino acid acetylation (GO:0006475)	NEW	4.99	0.004	BRCA2, ESR1, TP53, AKT1, CHEK2, TSG101
regulation of protein kinase activity (GO:0045859)	-	3.15	0.011	PHB, ATM, KRAS, AKT1, CASP8, TP53, CDH1, RAD51, ESR1, PIK3CA, BRCA1, CHEK2, HMMR
regulation of cell size (GO:0008361)	-	5.42	0.016	RB1CC1, KRAS, TP53, AKT1
glycerolipid metabolic process (GO:0046486)	-	3.91	0.0	ATM, KRAS, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, TSG101
somitogenesis (GO:0001756)	-	5.9	0.003	ATM, BRCA1, BRIP1, PALB2, TP53
heterocycle metabolic process (GO:0046483)	-	1.31	0.013	PHB, ATM, XRCC3, BRCA2, AKT1, PALB2, BARD1, TP53, FAM175A, RB1CC1, KRAS, ESR1, NBN, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
positive regulation of phosphorylation (GO:0042327)	-	2.9	0.001	ATM, NBN, KRAS, AKT1, CASP8, PPM1D, TP53, PHB, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
negative regulation of phosphorylation (GO:0042326)	-	3.7	0.0	ATM, KRAS, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
response to biotic stimulus (GO:0009607)	-	3.09	0.003	ATM, KRAS, AKT1, CASP8, PPM1D, RAD51, TP53, CDH1, PIK3CA, ESR1, RAD54L, CHEK2, HMMR
regulation of DNA replication (GO:0006275)	-	5.02	0.033	ATM, NBN, BRCA2, AKT1, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2
regulation of nuclear division (GO:0051783)	-	4.67	0.005	ATM, PPM1D, CDH1, TP53, AKT1, CHEK2, TSG101
positive regulation of catabolic process (GO:0009896)	-	3.94	0.022	ESR1, CASP8, BARD1, PIK3CA, CDH1, RB1CC1, TP53, AKT1
cell differentiation in hindbrain (GO:0021533)	NEW	6.64	0.0	CHEK2, ESR1, AKT1, TP53, CDH1
positive regulation of metabolic process (GO:0009893)	-	1.74	0.0	NBN, PHB, KRAS, BRCA2, AKT1, CASP8, CDH1, BARD1, PIK3CA, FAM175A, RB1CC1, TP53, ESR1, BRCA1, CHEK2, RAD51
positive regulation of canonical Wnt signaling pathway (GO:0090263)	NEW	4.95	0.017	TP53, BRCA1, ESR1, AKT1, CDH1
regulation of production of molecular mediator of immune response (GO:0002700)	NEW	5.1	0.005	ATM, ESR1, CASP8, CDH1, TP53, AKT1
regulation of catenin import into nucleus (GO:0035412)	NEW	6.47	0.003	TP53, AKT1, CDH1, PIK3CA
positive regulation of protein transport (GO:0051222)	-	3.61	0.016	ATM, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, HMMR
regulation of protein transport (GO:0051223)	-	3.12	0.001	ATM, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, HMMR, ESR1, PIK3CA, BRCA1, TSG101
signal transduction by p53 class mediator (GO:0072331)	-	4.88	0.001	ATM, NBN, BRCA2, TP53, CDH1, AKT1, BRCA1
spindle assembly (GO:0051225)	NEW	5.57	0.024	ATM, CHEK2, TP53, AKT1
regulation of oxidoreductase activity (GO:0051341)	-	5.27	0.004	PHB, ESR1, TP53, KRAS, CDH1, AKT1
negative regulation of transferase activity (GO:0051348)	-	3.87	0.0	ATM, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
response to interleukin-6 (GO:0070741)	NEW	6.78	0.004	PHB, ESR1, TP53, AKT1
organic cyclic compound metabolic process (GO:1901360)	-	1.26	0.027	ATM, NBN, XRCC3, BRCA2, AKT1, PALB2, BARD1, TP53, PHB, FAM175A, RB1CC1, KRAS, ESR1, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
regulation of establishment of protein localization (GO:0070201)	-	3.02	0.004	ATM, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, HMMR, ESR1, PIK3CA, BRCA1, TSG101
cell cycle arrest (GO:0007050)	-	4.69	0.002	ATM, NBN, AKT1, PPM1D, BARD1, TP53, KRAS, ESR1, BRCA1, TSG101
pattern specification process (GO:0007389)	-	3.79	0.0	ATM, BRCA2, AKT1, PALB2, PPM1D, TP53, CDH1, PIK3CA, ESR1, BRCA1, BRIP1, CHEK2, RAD51
mitotic spindle organization (GO:0007052)	NEW	6.29	0.003	TP53, CHEK2, AKT1, TSG101
cranial nerve development (GO:0021545)	NEW	6.68	0.015	BRCA1, ESR1, CHEK2, TP53
chromosome segregation (GO:0007059)	NEW	5.06	0.015	ATM, BRCA1, RAD51, TP53, AKT1
leukocyte differentiation (GO:0002521)	NEW	4.13	0.005	ATM, KRAS, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1
reproduction (GO:0000003)	NEW	7.16	0.017	TP53, CHEK2, AKT1, CDH1
positive regulation of mesenchymal cell proliferation (GO:0002053)	NEW	6.4	0.047	CHEK2, ESR1, AKT1, CDH1
nucleoside phosphate catabolic process (GO:1901292)	NEW	5.54	0.006	ATM, PHB, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
cellular response to alcohol (GO:0097306)	-	6.07	0.024	TP53, BRCA1, ESR1, AKT1, CDH1
positive regulation of transport (GO:0051050)	-	2.9	0.019	ATM, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, PIK3CA, ESR1, BRCA1, HMMR, CHEK2, TSG101
mesoderm development (GO:0007498)	NEW	5.72	0.008	TP53, BRCA1, RAD51, PALB2, CDH1
cellular response to inorganic substance (GO:0071241)	-	4.67	0.03	ATM, TP53, CDH1, RB1CC1, PIK3CA, AKT1
negative regulation of cellular component organization (GO:0051129)	-	3.35	0.001	ATM, KRAS, AKT1, CASP8, RAD51, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
regulation of protein catabolic process (GO:0042176)	-	3.83	0.0	BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2
negative regulation of mitotic cell cycle phase transition (GO:1901991)	-	4.82	0.0	ATM, NBN, ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1, RAD51
regulation of mitotic cell cycle phase transition (GO:1901990)	-	4.23	0.0	ATM, NBN, BRCA2, AKT1, TP53, CDH1, PIK3CA, ESR1, BRCA1, RAD51
intracellular signal transduction (GO:0035556)	-	2.39	0.005	ATM, NBN, KRAS, BRCA2, CASP8, PIK3CA, RB1CC1, TP53, AKT1, BRCA1, CHEK2
response to organic cyclic compound (GO:0014070)	-	3.07	0.025	PHB, KRAS, AKT1, CASP8, TP53, CDH1, RB1CC1, RAD51, ESR1, PIK3CA, BRCA1, CHEK2, TSG101
meiotic nuclear division (GO:0007126)	-	5.37	0.0	ATM, NBN, BRCA2, TP53, RAD51, AKT1, CHEK2, RAD54L, BRCA1, TSG101
positive regulation of protein metabolic process (GO:0051247)	-	2.43	0.0	ATM, NBN, KRAS, BRCA2, AKT1, CASP8, PPM1D, BARD1, RAD51, TP53, PHB, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	-	3.12	0.0	PHB, ATM, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, RAD51, ESR1, PIK3CA, BRCA1, CHEK2, TSG101
nuclear division (GO:0000280)	-	3.85	0.0	ATM, NBN, BRCA2, BARD1, TP53, CDH1, RAD51, AKT1, CHEK2, BRCA1, RAD54L, TSG101
negative regulation of cell proliferation (GO:0008285)	-	3.26	0.001	PHB, ATM, KRAS, BRCA2, AKT1, CASP8, PPM1D, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
insulin receptor signaling pathway (GO:0008286)	-	5.33	0.028	ESR1, TP53, CDH1, KRAS, AKT1, PIK3CA
regulation of body fluid levels (GO:0050878)	NEW	3.76	0.001	KRAS, BRCA2, AKT1, CASP8, RAD51, TP53, CDH1, HMMR, ESR1, PIK3CA, BRCA1, CHEK2, TSG101
cell proliferation (GO:0008283)	-	3.23	0.0	ATM, NBN, KRAS, BRCA2, AKT1, CASP8, PALB2, PPM1D, TP53, CDH1, PIK3CA, ESR1, BRCA1, BRIP1, CHEK2, RAD51
neurological system process (GO:0050877)	-	2.64	0.007	ATM, PHB, KRAS, NBN, AKT1, BARD1, TP53, CDH1, NQO2, ESR1, PIK3CA, BRCA1, CHEK2, TSG101
positive regulation of T cell activation (GO:0050870)	-	4.39	0.005	ATM, KRAS, ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1
cellular response to DNA damage stimulus (GO:0006974)	-	3.17	0.0	ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, PALB2, CDH1, BARD1, RAD51, TP53, FAM175A, PIK3CA, ESR1, CHEK2, BRCA1, BRIP1, RAD54L, TSG101
positive regulation of biological process (GO:0048518)	-	1.2	0.002	ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, CDH1, BARD1, TP53, PHB, FAM175A, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
regulation of cell growth (GO:0001558)	-	3.75	0.026	PHB, KRAS, AKT1, TP53, CDH1, TSG101, ESR1, BRCA1, CHEK2, HMMR
eye development (GO:0001654)	NEW	5.07	0.007	ESR1, CDH1, TP53, AKT1, CHEK2, BRCA1
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator (GO:0006978)	-	7.09	0.0	BRCA1, BRCA2, TP53, CDH1
response to oxidative stress (GO:0006979)	NEW	3.9	0.013	ATM, KRAS, ESR1, CDH1, RB1CC1, TP53, AKT1, BRCA1, CHEK2
glycerophospholipid biosynthetic process (GO:0046474)	-	4.62	0.0	ATM, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1
negative regulation of growth (GO:0045926)	-	4.24	0.005	PHB, KRAS, AKT1, TP53, CDH1, TSG101, ESR1, BRCA1, HMMR
apoptotic signaling pathway (GO:0097190)	-	4.12	0.0	ATM, NBN, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2
extrinsic apoptotic signaling pathway (GO:0097191)	NEW	5.16	0.005	ESR1, CASP8, TP53, PIK3CA, AKT1, BRCA1
intrinsic apoptotic signaling pathway (GO:0097193)	-	4.69	0.0	ATM, NBN, BRCA2, CASP8, PIK3CA, TP53, AKT1, BRCA1, CHEK2
cell cycle process (GO:0022402)	-	2.75	0.0	ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, PPM1D, CDH1, BARD1, RAD51, TP53, FAM175A, PIK3CA, ESR1, BRCA1, BRIP1, CHEK2, TSG101
lens development in camera-type eye (GO:0002088)	NEW	6.09	0.028	BRCA1, ESR1, TP53, AKT1
segmentation (GO:0035282)	-	5.8	0.047	ATM, BRCA1, BRIP1, PALB2, TP53
response to hyperoxia (GO:0055093)	NEW	6.4	0.001	TP53, ESR1, KRAS, AKT1
regulation of cell division (GO:0051302)	NEW	4.88	0.0	ATM, BRCA2, AKT1, PPM1D, BARD1, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
gamete generation (GO:0007276)	-	3.61	0.0	ATM, KRAS, BRCA2, AKT1, CASP8, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
response to toxic substance (GO:0009636)	-	4.88	0.011	KRAS, ESR1, CASP8, CDH1, RB1CC1, TP53, AKT1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	-	2.6	0.003	ATM, PHB, KRAS, BRCA2, AKT1, CASP8, BARD1, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, BRIP1, CHEK2, TSG101
positive regulation of apoptotic process (GO:0043065)	-	3.38	0.027	PHB, ATM, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, PIK3CA, ESR1
regulation of programmed cell death (GO:0043067)	-	2.49	0.0	ATM, PHB, KRAS, AKT1, CASP8, PALB2, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1
negative regulation of apoptotic process (GO:0043066)	-	3.04	0.0	ATM, KRAS, BRCA2, AKT1, CASP8, PALB2, BARD1, PIK3CA, CDH1, RB1CC1, TP53, ESR1, BRCA1, BRIP1, CHEK2, RAD51
positive regulation of leukocyte proliferation (GO:0070665)	NEW	4.79	0.004	ATM, KRAS, ESR1, CDH1, TP53, AKT1, PIK3CA
cell division (GO:0051301)	-	3.68	0.002	ESR1, CDH1, TP53, AKT1, BRCA1, CHEK2, TSG101
negative regulation of cell death (GO:0060548)	-	2.95	0.0	ATM, KRAS, BRCA2, AKT1, CASP8, PALB2, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, BRIP1, CHEK2, RAD51
regulation of nucleocytoplasmic transport (GO:0046822)	-	4.33	0.006	AKT1, BARD1, TP53, CDH1, PIK3CA, ESR1, BRCA1, TSG101
hepatocyte apoptotic process (GO:0097284)	NEW	7.16	0.004	CASP8, AKT1, CDH1
protein phosphorylation (GO:0006468)	-	2.89	0.043	PHB, ATM, KRAS, ESR1, TP53, CDH1, RB1CC1, PIK3CA, AKT1, BRCA1, CHEK2, RAD51
negative regulation of protein kinase activity (GO:0006469)	NEW	4.29	0.0	ATM, AKT1, CASP8, TP53, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
regulation of innate immune response (GO:0045088)	-	3.86	0.017	ATM, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1
regulation of lipid metabolic process (GO:0019216)	-	4.08	0.002	PHB, ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1, CHEK2, TSG101
regulation of nucleobase-containing compound metabolic process (GO:0019219)	-	1.43	0.015	NBN, PHB, KRAS, BRCA2, AKT1, CDH1, BARD1, RAD51, TP53, FAM175A, RB1CC1, PIK3CA, ESR1, BRCA1, BRIP1, CHEK2, TSG101
protein complex assembly (GO:0006461)	-	2.78	0.004	ATM, PHB, KRAS, BRCA2, AKT1, CASP8, RAD51, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
single-organism developmental process (GO:0044767)	-	1.49	0.027	ATM, NBN, KRAS, BRCA2, AKT1, CASP8, PALB2, TP53, PHB, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
multi-organism cellular process (GO:0044764)	-	3.14	0.041	PHB, KRAS, AKT1, CASP8, RAD51, TP53, TSG101, ESR1, PIK3CA, BRCA1, HMMR
single-organism cellular process (GO:0044763)	-	0.65	0.017	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, SLC22A18, BARD1, CDH1, AKT1, BRIP1, BRCA2, RAD51, ESR1, CHEK2, TSG101
positive regulation of protein processing (GO:0010954)	NEW	6.9	0.004	ESR1, CASP8, CDH1, TP53, AKT1, PIK3CA
regulation of nitric-oxide synthase activity (GO:0050999)	-	5.9	0.028	ESR1, KRAS, AKT1
chromosome organization (GO:0051276)	-	3.79	0.013	ATM, NBN, PPM1D, TP53, RAD54L, BRCA1, TSG101
inner cell mass cell proliferation (GO:0001833)	-	7.33	0.02	BRCA1, BRCA2, PALB2
positive regulation of JNK cascade (GO:0046330)	NEW	4.98	0.018	ATM, TP53, AKT1, PIK3CA, CDH1
positive regulation of peptidyl-lysine acetylation (GO:2000758)	NEW	6.29	0.004	BRCA1, ESR1, TP53, AKT1
negative regulation of cellular process (GO:0048523)	-	1.41	0.0	PHB, ATM, KRAS, BRCA2, AKT1, CASP8, PPM1D, PALB2, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, NBN, BRCA1, CHEK2, TSG101
regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	NEW	6.9	0.036	BRCA1, TP53, AKT1
regulation of T cell apoptotic process (GO:0070232)	NEW	6.2	0.001	KRAS, TP53, CASP8, ESR1, PIK3CA
positive regulation of defense response (GO:0031349)	-	3.83	0.001	ATM, KRAS, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, HMMR
regulation of neuron apoptotic process (GO:0043523)	-	4.47	0.007	ATM, KRAS, ESR1, CASP8, TP53, PIK3CA, AKT1, CHEK2
mitochondrial membrane organization (GO:0007006)	-	5.2	0.0	ATM, PHB, BRCA1, TP53, AKT1
regulation of defense response (GO:0031347)	-	3.11	0.009	ATM, KRAS, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, HMMR
positive regulation of cell projection organization (GO:0031346)	NEW	3.99	0.003	KRAS, ESR1, BARD1, TP53, CDH1, PIK3CA, AKT1, BRCA1, CHEK2
single-organism metabolic process (GO:0044710)	-	1.63	0.0	ATM, PHB, XRCC3, KRAS, BRCA2, AKT1, PALB2, BARD1, RAD51, TP53, FAM175A, RB1CC1, NQO2, ESR1, PIK3CA, NBN, CHEK2, BRCA1, BRIP1, RAD54L, HMMR
neuron projection guidance (GO:0097485)	NEW	4.43	0.001	ATM, KRAS, ESR1, TP53, CDH1, RB1CC1, PIK3CA, AKT1, BRCA1, CHEK2, RAD51
response to indole-3-methanol (GO:0071680)	-	8.12	0.029	BRCA1, CDH1
positive regulation of cell cycle (GO:0045787)	-	3.94	0.003	ATM, BRCA2, ESR1, CDH1, TP53, AKT1, CHEK2
response to epidermal growth factor (GO:0070849)	NEW	6.29	0.015	TP53, BRCA1, AKT1, CDH1
regulation of inflammatory response (GO:0050727)	NEW	4.03	0.027	ATM, ESR1, TP53, CDH1, PIK3CA, AKT1, CHEK2, HMMR
negative regulation of neuron differentiation (GO:0045665)	NEW	4.45	0.001	ESR1, CDH1, TP53, AKT1, CHEK2, BRCA1
regulation of neuron differentiation (GO:0045664)	NEW	3.39	0.004	ATM, KRAS, BRCA2, AKT1, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2
negative regulation of myoblast differentiation (GO:0045662)	NEW	6.55	0.045	TP53, AKT1, CDH1
regulation of signal transduction by p53 class mediator (GO:1901796)	-	4.63	0.024	ATM, ESR1, TP53, CDH1
ribonucleoside catabolic process (GO:0042454)	NEW	6.55	0.003	PHB, ATM, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
hyaluronan metabolic process (GO:0030212)	-	6.29	0.006	ATM, CDH1, AKT1, HMMR
positive regulation of DNA metabolic process (GO:0051054)	-	4.49	0.0	ATM, ESR1, TP53, FAM175A, CDH1, AKT1, BRCA1, RAD51
negative regulation of DNA metabolic process (GO:0051053)	-	4.98	0.0	ATM, BRCA2, ESR1, CDH1, TP53, AKT1, CHEK2
regulation of DNA metabolic process (GO:0051052)	-	3.87	0.0	ATM, NBN, BRCA2, AKT1, CDH1, TP53, FAM175A, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
histone H3 acetylation (GO:0043966)	NEW	5.92	0.038	CHEK2, BRCA2, ESR1, TP53
T cell differentiation (GO:0030217)	NEW	5.11	0.028	ESR1, TP53, CDH1, KRAS, AKT1, BRCA1
ATP metabolic process (GO:0046034)	NEW	4.98	0.002	PHB, ATM, XRCC3, BRCA2, AKT1, TP53, ESR1, BRCA1, BRIP1, RAD51
response to metal ion (GO:0010038)	-	3.91	0.005	KRAS, ESR1, CASP8, CDH1, RB1CC1, TP53, AKT1, PIK3CA, CHEK2
negative regulation of response to DNA damage stimulus (GO:2001021)	NEW	5.78	0.001	TP53, BRCA1, ESR1, AKT1, CDH1
regulation of response to DNA damage stimulus (GO:2001020)	-	4.74	0.0	ATM, AKT1, PPM1D, TP53, FAM175A, CDH1, ESR1, BRCA1, RAD51
response to inorganic substance (GO:0010035)	-	3.56	0.002	ATM, KRAS, AKT1, CASP8, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2
response to other organism (GO:0051707)	NEW	3.48	0.031	ATM, AKT1, CASP8, PPM1D, RAD51, TP53, CDH1, PIK3CA, ESR1, HMMR
stem cell maintenance (GO:0019827)	NEW	4.83	0.045	ATM, ESR1, CDH1, TP53, AKT1, BRCA1
cellular response to extracellular stimulus (GO:0031668)	-	4.57	0.006	KRAS, ESR1, CDH1, RB1CC1, TP53, AKT1, BRCA1
cellular response to nutrient levels (GO:0031669)	-	4.7	0.002	KRAS, ESR1, CDH1, RB1CC1, TP53, AKT1, BRCA1
negative regulation of programmed cell death (GO:0043069)	-	3.02	0.0	ATM, KRAS, BRCA2, AKT1, CASP8, PALB2, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, BRIP1, CHEK2, RAD51
regulation of DNA recombination (GO:0000018)	NEW	5.65	0.004	ATM, NBN, ESR1, RAD51, TP53
positive regulation of programmed cell death (GO:0043068)	-	3.38	0.028	PHB, ATM, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, PIK3CA, ESR1
chromatin modification (GO:0016568)	NEW	4.06	0.0	ATM, NBN, KRAS, BRCA2, AKT1, CDH1, BARD1, TP53, PHB, FAM175A, RAD51, ESR1, BRCA1, CHEK2, TSG101
covalent chromatin modification (GO:0016569)	-	3.89	0.0	PHB, ATM, BRCA2, AKT1, TP53, ESR1, NBN, BRCA1, CHEK2, RAD51
leukocyte activation (GO:0045321)	-	3.76	0.0	ATM, NBN, KRAS, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, HMMR
nitrogen compound metabolic process (GO:0006807)	-	1.13	0.015	ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, PALB2, BARD1, TP53, PHB, FAM175A, RB1CC1, RAD51, ESR1, CHEK2, BRCA1, BRIP1, RAD54L, HMMR
neuron migration (GO:0001764)	NEW	5.0	0.019	ATM, ESR1, CDH1, TP53, AKT1, PIK3CA, CHEK2
nucleoside monophosphate metabolic process (GO:0009123)	NEW	4.54	0.006	PHB, ATM, XRCC3, BRCA2, AKT1, TP53, ESR1, BRCA1, BRIP1, RAD51
purine nucleotide catabolic process (GO:0006195)	NEW	6.07	0.004	ATM, PHB, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
positive regulation of myeloid leukocyte differentiation (GO:0002763)	NEW	5.82	0.004	BRCA1, CASP8, ESR1, CDH1, AKT1
cellular macromolecule catabolic process (GO:0044265)	-	3.19	0.0	ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, PPM1D, RAD51, TP53, CDH1, PIK3CA, ESR1, CHEK2, RAD54L, BRCA1, TSG101
cellular macromolecule metabolic process (GO:0044260)	-	0.93	0.032	ATM, PHB, XRCC3, BRCA2, AKT1, PPM1D, PALB2, BARD1, RAD51, TP53, FAM175A, RB1CC1, PIK3CA, ESR1, NBN, CHEK2, BRCA1, BRIP1, RAD54L, TSG101
blood vessel development (GO:0001568)	NEW	4.95	0.019	ESR1, CDH1, TP53, AKT1, CHEK2, TSG101
regulation of JAK-STAT cascade (GO:0046425)	NEW	4.78	0.001	ESR1, CDH1, TP53, AKT1, PIK3CA, CHEK2
cellular response to fibroblast growth factor stimulus (GO:0044344)	NEW	6.4	0.012	KRAS, ESR1, CDH1, TP53, AKT1, PIK3CA, CHEK2
negative regulation of MAPK cascade (GO:0043409)	-	4.74	0.0	ATM, KRAS, CASP8, PIK3CA, CDH1, TP53, AKT1, RAD51
regulation of cell projection organization (GO:0031344)	NEW	3.38	0.001	KRAS, AKT1, BARD1, RAD51, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
organ morphogenesis (GO:0009887)	NEW	3.55	0.0	ATM, BRCA2, AKT1, PALB2, RAD51, TP53, CDH1, RB1CC1, TSG101, ESR1, BRCA1, BRIP1, CHEK2, HMMR
hexose metabolic process (GO:0019318)	-	4.64	0.001	KRAS, ESR1, TP53, CDH1, TSG101, AKT1, PIK3CA, RAD51
tissue development (GO:0009888)	-	3.27	0.0	NBN, BRCA2, AKT1, CASP8, PALB2, BARD1, TP53, CDH1, RB1CC1, RAD51, ESR1, BRCA1, BRIP1, CHEK2, TSG101
somatic stem cell maintenance (GO:0035019)	NEW	5.52	0.009	TP53, BRCA1, ESR1, KRAS, AKT1
cellular nitrogen compound metabolic process (GO:0034641)	-	1.22	0.024	ATM, PHB, XRCC3, BRCA2, AKT1, PALB2, BARD1, TP53, FAM175A, RB1CC1, KRAS, ESR1, NBN, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
cellular response to ionizing radiation (GO:0071479)	-	5.78	0.033	ATM, RAD51, TP53, AKT1
organophosphate biosynthetic process (GO:0090407)	-	3.67	0.006	PHB, ATM, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, RAD51
endocytosis (GO:0006897)	NEW	3.69	0.004	KRAS, AKT1, CASP8, TP53, CDH1, TSG101, ESR1, PIK3CA, CHEK2, HMMR
anterior/posterior pattern specification (GO:0009952)	-	4.71	0.0	ATM, BRCA2, AKT1, PALB2, TP53, CDH1, ESR1, BRCA1, BRIP1, CHEK2
phospholipid biosynthetic process (GO:0008654)	-	4.39	0.001	ATM, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1
regulation of epithelial to mesenchymal transition (GO:0010717)	NEW	5.55	0.01	TP53, RB1CC1, ESR1, AKT1, CDH1
response to stimulus (GO:0050896)	-	1.22	0.0	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1, BRIP1, BRCA2, NQO2, ESR1, CHEK2, RAD51
regulation of transferase activity (GO:0051338)	-	2.88	0.009	PHB, ATM, KRAS, NBN, AKT1, CASP8, TP53, CDH1, RAD51, ESR1, PIK3CA, BRCA1, CHEK2, HMMR
positive regulation of leukocyte activation (GO:0002696)	-	4.0	0.008	ATM, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1
positive regulation of protein maturation (GO:1903319)	NEW	6.84	0.004	ESR1, CASP8, CDH1, TP53, AKT1, PIK3CA
camera-type eye development (GO:0043010)	NEW	5.36	0.021	TP53, BRCA1, ESR1, CHEK2, AKT1
regulation of cell morphogenesis (GO:0022604)	NEW	3.4	0.009	KRAS, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2
cellular response to gamma radiation (GO:0071480)	-	6.78	0.013	ATM, TP53, AKT1
regulation of organelle organization (GO:0033043)	-	2.72	0.001	ATM, XRCC3, KRAS, AKT1, CASP8, PPM1D, BARD1, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
response to radiation (GO:0009314)	-	3.69	0.0	PHB, ATM, KRAS, BRCA2, CASP8, PALB2, PPM1D, TP53, FAM175A, RAD51, AKT1, CHEK2, RAD54L, BRCA1, HMMR
mammary gland epithelial cell proliferation (GO:0033598)	NEW	7.24	0.032	ESR1, TP53, AKT1
regulation of mammary gland epithelial cell proliferation (GO:0033599)	NEW	6.84	0.045	BRCA2, ESR1, TP53
trigeminal nerve development (GO:0021559)	NEW	8.34	0.0	CHEK2, ESR1, TP53
single-organism process (GO:0044699)	-	0.48	0.01	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, SLC22A18, BARD1, CDH1, AKT1, BRIP1, HMMR, BRCA2, NQO2, RAD51, ESR1, CHEK2, TSG101
regulation of neurogenesis (GO:0050767)	NEW	3.21	0.032	ATM, KRAS, BRCA2, AKT1, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2
negative regulation of protein metabolic process (GO:0051248)	-	2.82	0.0	ATM, KRAS, BRCA2, AKT1, CASP8, BARD1, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, HMMR
response to ionizing radiation (GO:0010212)	-	4.74	0.0	ATM, BRCA2, PALB2, TP53, FAM175A, AKT1, CHEK2, BRCA1, RAD54L, RAD51
positive regulation of phosphorus metabolic process (GO:0010562)	-	2.78	0.002	PHB, ATM, KRAS, NBN, AKT1, CASP8, PPM1D, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
negative regulation of phosphorus metabolic process (GO:0010563)	-	3.45	0.002	ATM, KRAS, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
regulation of cell cycle process (GO:0010564)	-	3.5	0.0	ATM, NBN, XRCC3, BRCA2, AKT1, PPM1D, BARD1, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
regulation of cellular ketone metabolic process (GO:0010565)	-	4.67	0.001	ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1, CHEK2, TSG101
regulation of cell morphogenesis involved in differentiation (GO:0010769)	NEW	3.91	0.028	KRAS, ESR1, CDH1, RB1CC1, TP53, AKT1, PIK3CA, BRCA1, CHEK2
regulation of morphogenesis of a branching structure (GO:0060688)	NEW	5.76	0.008	CHEK2, BRCA1, ESR1, AKT1, CDH1
central nervous system neuron differentiation (GO:0021953)	NEW	5.17	0.023	ATM, ESR1, CDH1, TP53, AKT1, CHEK2
regulation of intrinsic apoptotic signaling pathway (GO:2001242)	-	4.74	0.05	ESR1, CASP8, CDH1, TP53, AKT1, BRCA1
reproductive structure development (GO:0048608)	-	4.08	0.0	ATM, BRCA2, AKT1, CASP8, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
multicellular organismal reproductive process (GO:0048609)	-	3.35	0.002	ATM, KRAS, BRCA2, AKT1, CASP8, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
regulation of stress-activated protein kinase signaling cascade (GO:0070302)	NEW	4.44	0.025	ATM, ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1
cellular response to lipid (GO:0071396)	NEW	3.96	0.029	ATM, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, TSG101
positive regulation of stress-activated protein kinase signaling cascade (GO:0070304)	NEW	4.82	0.0	ATM, ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1
regulation of toll-like receptor signaling pathway (GO:0034121)	NEW	5.88	0.04	ESR1, TP53, AKT1, PIK3CA
male gamete generation (GO:0048232)	NEW	3.7	0.003	ATM, KRAS, BRCA2, AKT1, CASP8, RAD51, TP53, CDH1, PIK3CA, ESR1, TSG101
nerve development (GO:0021675)	NEW	6.29	0.003	TP53, BRCA1, ESR1, CHEK2, CDH1
negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)	NEW	7.43	0.015	AKT1, TP53, PIK3CA
single-organism intracellular transport (GO:1902582)	NEW	3.59	0.047	ATM, PHB, KRAS, AKT1, CASP8, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
carbohydrate derivative catabolic process (GO:1901136)	NEW	4.61	0.0	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, TP53, CDH1, RAD51, ESR1, PIK3CA, BRCA1, BRIP1, CHEK2, HMMR
response to drug (GO:0042493)	-	3.71	0.002	KRAS, ESR1, CASP8, TP53, CDH1, RB1CC1, PIK3CA, AKT1, RAD54L, CHEK2, RAD51
response to molecule of bacterial origin (GO:0002237)	NEW	3.99	0.033	ATM, KRAS, ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1
system development (GO:0048731)	-	2.92	0.048	PHB, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
central nervous system projection neuron axonogenesis (GO:0021952)	NEW	6.73	0.006	BRCA1, ESR1, TP53, AKT1
negative regulation of ERK1 and ERK2 cascade (GO:0070373)	NEW	5.74	0.04	TP53, KRAS, AKT1, CDH1
regulation of ERK1 and ERK2 cascade (GO:0070372)	-	4.23	0.015	ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1, RAD51
embryonic limb morphogenesis (GO:0030326)	NEW	5.24	0.005	ESR1, CDH1, TP53, AKT1, CHEK2, BRCA1
regulation of peptidyl-serine phosphorylation (GO:0033135)	-	4.98	0.009	ATM, ESR1, KRAS, CDH1, AKT1, PIK3CA
positive regulation of cell activation (GO:0050867)	-	3.97	0.001	ATM, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1
regulation of DNA methylation (GO:0044030)	-	6.78	0.001	BRCA1, TP53, AKT1, PIK3CA
regulation of T cell activation (GO:0050863)	-	4.05	0.005	ATM, KRAS, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1
purine-containing compound catabolic process (GO:0072523)	NEW	5.92	0.005	ATM, PHB, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
negative regulation of protein serine/threonine kinase activity (GO:0071901)	NEW	4.92	0.014	CASP8, PIK3CA, TP53, AKT1, CHEK2, BRCA1
osteoblast differentiation (GO:0001649)	-	5.05	0.036	PHB, ESR1, TP53, KRAS, CDH1, AKT1
regulation of protein serine/threonine kinase activity (GO:0071900)	-	3.58	0.0	ATM, PHB, KRAS, BRCA2, AKT1, CASP8, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, HMMR
chromatin organization (GO:0006325)	-	3.28	0.0	PHB, ATM, KRAS, BRCA2, AKT1, CDH1, BARD1, TP53, FAM175A, RAD51, ESR1, NBN, BRCA1, CHEK2, TSG101
regulation of apoptotic process (GO:0042981)	-	2.5	0.0	ATM, PHB, KRAS, AKT1, CASP8, PALB2, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1
regulation of cell adhesion mediated by integrin (GO:0033628)	NEW	6.04	0.036	TP53, AKT1, CDH1, PIK3CA
regulation of cell cycle arrest (GO:0071156)	-	5.05	0.002	ATM, ESR1, CDH1, TP53, AKT1, BRCA1
positive regulation of mitotic cell cycle (GO:0045931)	-	4.98	0.0	TP53, ESR1, BRCA2, KRAS, AKT1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	-	2.35	0.015	PHB, BRCA2, ESR1, TP53, FAM175A, CDH1, AKT1, BRCA1, CHEK2, RAD51
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	-	2.55	0.0	ATM, PHB, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, RAD51, ESR1, PIK3CA, NBN, BRCA1, BRIP1, CHEK2, TSG101
positive regulation of phosphate metabolic process (GO:0045937)	-	2.78	0.002	ATM, NBN, KRAS, AKT1, CASP8, PPM1D, TP53, PHB, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
negative regulation of phosphate metabolic process (GO:0045936)	-	3.45	0.002	ATM, KRAS, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
embryonic hindlimb morphogenesis (GO:0035116)	NEW	6.36	0.022	CHEK2, ESR1, TP53, CDH1
genitalia morphogenesis (GO:0035112)	NEW	7.43	0.017	BRCA1, ESR1, TP53
embryonic appendage morphogenesis (GO:0035113)	NEW	5.24	0.005	ESR1, CDH1, TP53, AKT1, CHEK2, BRCA1
Ras protein signal transduction (GO:0007265)	-	4.76	0.0	KRAS, ESR1, CDH1, RB1CC1, TP53, AKT1, PIK3CA, CHEK2
small GTPase mediated signal transduction (GO:0007264)	-	3.85	0.012	ATM, KRAS, ESR1, TP53, CDH1, RB1CC1, PIK3CA, AKT1, CHEK2, RAD51
lipid biosynthetic process (GO:0008610)	-	3.49	0.004	ATM, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, PIK3CA, ESR1, BRCA1, TSG101
organelle organization (GO:0006996)	-	2.02	0.001	PHB, ATM, KRAS, BRCA2, TP53, RB1CC1, RAD51, AKT1, NBN, CHEK2, RAD54L, BRCA1, TSG101
response to abiotic stimulus (GO:0009628)	-	2.8	0.0	ATM, NBN, KRAS, BRCA2, AKT1, CASP8, PALB2, CDH1, PPM1D, RAD51, TP53, PHB, FAM175A, RB1CC1, PIK3CA, ESR1, CHEK2, BRCA1, RAD54L, HMMR
carbohydrate metabolic process (GO:0005975)	-	3.26	0.02	ATM, KRAS, AKT1, CASP8, RAD51, TP53, CDH1, HMMR, ESR1, PIK3CA, BRCA1, TSG101
regulation of leukocyte apoptotic process (GO:2000106)	NEW	5.33	0.003	ESR1, CASP8, KRAS, TP53, AKT1, PIK3CA
DNA metabolic process (GO:0006259)	-	3.09	0.0	ATM, PHB, XRCC3, BRCA2, AKT1, PPM1D, PALB2, BARD1, TP53, FAM175A, RAD51, ESR1, PIK3CA, NBN, CHEK2, BRCA1, BRIP1, RAD54L, TSG101
symbiosis, encompassing mutualism through parasitism (GO:0044403)	-	3.15	0.037	PHB, KRAS, AKT1, CASP8, RAD51, TP53, TSG101, ESR1, PIK3CA, BRCA1, HMMR
positive regulation of cellular process (GO:0048522)	-	1.3	0.0	ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, CDH1, BARD1, TP53, PHB, FAM175A, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
negative regulation of apoptotic signaling pathway (GO:2001234)	-	4.42	0.047	ESR1, CASP8, CDH1, RB1CC1, TP53, AKT1, BRCA1
regulation of extrinsic apoptotic signaling pathway (GO:2001236)	-	4.69	0.001	KRAS, CASP8, CDH1, RB1CC1, TP53, AKT1, BRCA1, HMMR
anatomical structure homeostasis (GO:0060249)	-	4.25	0.001	ATM, NBN, ESR1, BARD1, TP53, RB1CC1, KRAS, AKT1, BRCA1
protein dephosphorylation (GO:0006470)	NEW	4.47	0.004	CASP8, PPM1D, CDH1, TP53, AKT1, CHEK2, RAD51
protein acetylation (GO:0006473)	NEW	4.86	0.007	BRCA2, ESR1, TP53, AKT1, CHEK2, TSG101
cell development (GO:0048468)	-	3.28	0.031	ATM, KRAS, BRCA2, AKT1, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
cell maturation (GO:0048469)	NEW	4.98	0.0	KRAS, BRCA2, ESR1, CDH1, TP53, AKT1, CHEK2, RAD51
regulation of Wnt signaling pathway (GO:0030111)	NEW	3.98	0.022	ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1, BRCA1, CHEK2
response to alkaloid (GO:0043279)	NEW	4.83	0.037	BRCA2, CASP8, PIK3CA, TP53, AKT1, RAD51
purine ribonucleoside catabolic process (GO:0046130)	NEW	7.16	0.003	PHB, ATM, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
cellular component organization or biogenesis (GO:0071840)	-	1.22	0.006	ATM, NBN, KRAS, BRCA2, AKT1, CASP8, CDH1, TP53, PHB, FAM175A, RB1CC1, RAD51, ESR1, CHEK2, RAD54L, BRCA1, TSG101
negative regulation of signal transduction (GO:0009968)	-	2.75	0.032	PHB, ATM, KRAS, AKT1, CASP8, TP53, CDH1, RB1CC1, RAD51, ESR1, PIK3CA, BRCA1, CHEK2, HMMR
positive regulation of signal transduction (GO:0009967)	-	2.5	0.004	ATM, PHB, KRAS, AKT1, CASP8, PPM1D, BARD1, RAD51, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, HMMR
rhythmic process (GO:0048511)	-	4.02	0.047	ATM, BRCA2, ESR1, TP53, CDH1, AKT1, CHEK2, RAD51
sensory organ development (GO:0007423)	NEW	4.82	0.034	ESR1, CDH1, TP53, AKT1, CHEK2, BRCA1
negative regulation of cell development (GO:0010721)	NEW	4.02	0.031	KRAS, ESR1, CDH1, RB1CC1, TP53, AKT1, PIK3CA
negative regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043124)	-	5.78	0.025	CASP8, ESR1, TP53, AKT1
negative regulation of biological process (GO:0048519)	-	1.33	0.0	PHB, ATM, KRAS, BRCA2, AKT1, CASP8, PPM1D, PALB2, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, NBN, BRCA1, CHEK2, TSG101
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122)	-	4.27	0.046	ATM, KRAS, ESR1, CASP8, TP53, PIK3CA, AKT1
regulation of cell proliferation (GO:0042127)	-	2.41	0.001	PHB, ATM, KRAS, BRCA2, AKT1, PPM1D, TP53, CDH1, ESR1, BRCA1, TSG101
regulation of lymphocyte apoptotic process (GO:0070228)	NEW	5.7	0.009	KRAS, TP53, CASP8, ESR1, PIK3CA
cell-substrate adhesion (GO:0031589)	NEW	4.75	0.0	ATM, KRAS, ESR1, CDH1, RB1CC1, TP53, AKT1, TSG101
sensory perception of sound (GO:0007605)	NEW	4.82	0.01	KRAS, ESR1, CDH1, TP53, AKT1, BRCA1, TSG101
regulation of T cell proliferation (GO:0042129)	NEW	4.74	0.004	ATM, KRAS, ESR1, CASP8, CDH1, TP53, AKT1
negative regulation of epithelial cell proliferation (GO:0050680)	NEW	4.98	0.002	KRAS, BRCA2, ESR1, CDH1, TP53, AKT1, TSG101
developmental process involved in reproduction (GO:0003006)	-	3.36	0.034	ATM, BRCA2, AKT1, CASP8, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
regionalization (GO:0003002)	-	4.24	0.0	ATM, BRCA2, AKT1, PALB2, PPM1D, TP53, CDH1, PIK3CA, ESR1, BRCA1, BRIP1, CHEK2
negative regulation of sequence-specific DNA binding transcription factor activity (GO:0043433)	NEW	4.82	0.007	PHB, ATM, KRAS, ESR1, CDH1, TP53, AKT1
cell aging (GO:0007569)	-	5.54	0.0	ATM, BRCA2, CDH1, TP53, AKT1, CHEK2
multi-organism reproductive process (GO:0044703)	NEW	4.82	0.031	BRCA2, ESR1, CDH1, TP53, AKT1, PIK3CA, CHEK2
organonitrogen compound catabolic process (GO:1901565)	NEW	3.91	0.0	ATM, PHB, XRCC3, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, RAD51, ESR1, PIK3CA, BRCA1, BRIP1, CHEK2, HMMR
response to organonitrogen compound (GO:0010243)	-	3.2	0.01	ATM, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
cellular response to stress (GO:0033554)	-	2.51	0.0	ATM, NBN, BRCA2, XRCC3, PALB2, BARD1, TP53, FAM175A, RB1CC1, AKT1, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
regulation of cellular component size (GO:0032535)	-	4.21	0.01	KRAS, ESR1, CDH1, RB1CC1, TP53, AKT1, RAD51
negative regulation of kinase activity (GO:0033673)	NEW	4.22	0.001	ATM, AKT1, CASP8, TP53, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
ovulation cycle process (GO:0022602)	NEW	5.25	0.0	ATM, BRCA2, ESR1, CDH1, AKT1, CHEK2, RAD51
nucleoside triphosphate metabolic process (GO:0009141)	NEW	4.61	0.01	PHB, ATM, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
nucleoside triphosphate catabolic process (GO:0009143)	NEW	7.24	0.002	ATM, PHB, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
purine nucleoside triphosphate metabolic process (GO:0009144)	NEW	4.76	0.007	PHB, ATM, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
purine nucleoside triphosphate catabolic process (GO:0009146)	NEW	7.94	0.002	PHB, ATM, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
developmental maturation (GO:0021700)	NEW	4.7	0.0	KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1, CHEK2
signal transduction involved in DNA integrity checkpoint (GO:0072401)	-	5.55	0.038	ATM, CHEK2, ESR1, TP53
positive regulation of cell cycle process (GO:0090068)	-	4.25	0.015	ATM, XRCC3, ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1
G2 DNA damage checkpoint (GO:0031572)	-	6.26	0.0	ATM, NBN, TP53, FAM175A, AKT1, BRCA1
DNA integrity checkpoint (GO:0031570)	-	5.25	0.0	ATM, NBN, TP53, FAM175A, PIK3CA, AKT1, BRCA1, BRIP1, CHEK2
regulation of kinase activity (GO:0043549)	-	3.07	0.003	PHB, ATM, KRAS, NBN, AKT1, CASP8, TP53, CDH1, RAD51, ESR1, PIK3CA, BRCA1, CHEK2, HMMR
regulation of anatomical structure size (GO:0090066)	-	3.78	0.017	KRAS, ESR1, CDH1, RB1CC1, TP53, AKT1, BRCA1, RAD51
histone modification (GO:0016570)	-	3.91	0.0	PHB, ATM, BRCA2, AKT1, TP53, ESR1, NBN, BRCA1, CHEK2, RAD51
cellular response to molecule of bacterial origin (GO:0071219)	NEW	4.88	0.016	ATM, ESR1, CDH1, TP53, AKT1, PIK3CA
cellular response to biotic stimulus (GO:0071216)	NEW	4.76	0.0	ATM, ESR1, TP53, CDH1, PIK3CA, AKT1, RAD54L, RAD51
cellular response to abiotic stimulus (GO:0071214)	-	4.15	0.025	ATM, CASP8, PALB2, PIK3CA, CDH1, TP53, AKT1, BRCA1, RAD51
anatomical structure formation involved in morphogenesis (GO:0048646)	-	3.01	0.0	ATM, KRAS, BRCA2, AKT1, CASP8, PALB2, RAD51, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, BRIP1, CHEK2, HMMR
internal peptidyl-lysine acetylation (GO:0018393)	NEW	5.05	0.003	BRCA2, ESR1, TP53, AKT1, CHEK2, TSG101
peptidyl-lysine acetylation (GO:0018394)	NEW	5.03	0.003	BRCA2, ESR1, TP53, AKT1, CHEK2, TSG101
sensory perception of mechanical stimulus (GO:0050954)	NEW	4.79	0.001	KRAS, ESR1, CDH1, TP53, AKT1, BRCA1, CHEK2, TSG101
heterocycle catabolic process (GO:0046700)	NEW	3.82	0.0	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, PPM1D, TP53, CDH1, RAD51, ESR1, PIK3CA, RAD54L, BRIP1, CHEK2, TSG101
response to stress (GO:0006950)	-	1.8	0.0	ATM, NBN, KRAS, BRCA2, XRCC3, CASP8, PALB2, BARD1, TP53, FAM175A, RB1CC1, PIK3CA, AKT1, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
negative regulation of intracellular signal transduction (GO:1902532)	-	3.63	0.001	ATM, KRAS, AKT1, CASP8, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, HMMR
regulation of protein import into nucleus (GO:0042306)	-	4.54	0.015	ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1, TSG101
cellular response to indole-3-methanol (GO:0071681)	-	8.12	0.029	BRCA1, CDH1
proteolysis involved in cellular protein catabolic process (GO:0051603)	-	3.59	0.027	PHB, ATM, KRAS, CASP8, TP53, CDH1, BRCA1, TSG101
cellular nitrogen compound catabolic process (GO:0044270)	NEW	3.8	0.0	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, PPM1D, BARD1, TP53, CDH1, RAD51, ESR1, PIK3CA, RAD54L, BRIP1, CHEK2, TSG101
protein maturation (GO:0051604)	NEW	4.48	0.009	KRAS, ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1, TSG101
negative regulation of protein modification process (GO:0031400)	-	3.4	0.0	ATM, KRAS, BRCA2, AKT1, CASP8, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, HMMR
positive regulation of protein modification process (GO:0031401)	-	2.7	0.0	ATM, NBN, KRAS, BRCA2, AKT1, CASP8, PPM1D, RAD51, TP53, PHB, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
response to increased oxygen levels (GO:0036296)	NEW	6.4	0.001	TP53, KRAS, ESR1, AKT1
cell activation (GO:0001775)	-	3.47	0.0	ATM, NBN, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, HMMR
DNA strand renaturation (GO:0000733)	-	7.53	0.002	ATM, RAD54L, TP53
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway (GO:1900740)	-	6.33	0.011	CASP8, TP53, AKT1
CD4-positive, alpha-beta T cell activation (GO:0035710)	NEW	6.4	0.025	ATM, KRAS, ESR1, AKT1
positive regulation of monooxygenase activity (GO:0032770)	-	6.47	0.004	KRAS, ESR1, AKT1, CDH1
response to growth factor (GO:0070848)	NEW	4.14	0.0	ATM, PHB, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, HMMR
response to antibiotic (GO:0046677)	-	5.86	0.004	RB1CC1, CASP8, ESR1, TP53, AKT1
positive regulation of intracellular signal transduction (GO:1902533)	-	2.95	0.01	ATM, PHB, KRAS, AKT1, CASP8, PPM1D, TP53, CDH1, RB1CC1, PIK3CA, ESR1, CHEK2, RAD51
epidermis development (GO:0008544)	NEW	5.04	0.005	ESR1, CASP8, TP53, AKT1, BRCA1, CHEK2, TSG101
fibroblast growth factor receptor signaling pathway (GO:0008543)	NEW	5.3	0.038	ESR1, TP53, CDH1, KRAS, AKT1, PIK3CA
protein autophosphorylation (GO:0046777)	-	4.46	0.007	ATM, CDH1, TP53, AKT1, BRCA1, CHEK2, RAD51
nucleobase-containing compound metabolic process (GO:0006139)	-	1.35	0.007	ATM, NBN, XRCC3, BRCA2, AKT1, PALB2, BARD1, TP53, PHB, FAM175A, RB1CC1, KRAS, ESR1, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)	NEW	6.09	0.012	BRCA1, CASP8, TP53, AKT1
purine nucleoside metabolic process (GO:0042278)	NEW	4.32	0.027	PHB, ATM, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
regulation of protein modification by small protein conjugation or removal (GO:1903320)	NEW	4.14	0.015	KRAS, BRCA2, ESR1, TP53, PIK3CA, AKT1, BRCA1
positive regulation of protein modification by small protein conjugation or removal (GO:1903322)	NEW	4.48	0.012	ESR1, KRAS, TP53, AKT1, PIK3CA, BRCA1
negative regulation of lipid metabolic process (GO:0045833)	-	5.33	0.001	ESR1, CDH1, TP53, AKT1, PIK3CA, BRCA1
positive regulation of cellular protein metabolic process (GO:0032270)	-	2.49	0.0	ATM, NBN, KRAS, BRCA2, AKT1, CASP8, PPM1D, RAD51, TP53, PHB, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
cellular response to endogenous stimulus (GO:0071495)	-	3.33	0.026	ATM, KRAS, AKT1, CASP8, RAD51, TP53, CDH1, RB1CC1, PIK3CA, ESR1, CHEK2, RAD54L, HMMR, BRCA1, TSG101
phospholipid metabolic process (GO:0006644)	-	3.88	0.025	ATM, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1
cellular response to external stimulus (GO:0071496)	-	4.2	0.001	KRAS, ESR1, CASP8, TP53, CDH1, RB1CC1, PIK3CA, AKT1, BRCA1
regulation of protein localization to nucleus (GO:1900180)	-	4.34	0.002	KRAS, ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1, TSG101
DNA duplex unwinding (GO:0032508)	-	5.37	0.043	NBN, BRIP1, RAD51, TP53
cellular aromatic compound metabolic process (GO:0006725)	-	1.3	0.014	PHB, ATM, XRCC3, BRCA2, AKT1, PALB2, BARD1, TP53, FAM175A, RB1CC1, KRAS, ESR1, NBN, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
positive regulation of stress-activated MAPK cascade (GO:0032874)	NEW	4.82	0.002	ATM, ESR1, CDH1, TP53, AKT1, PIK3CA
mammary gland branching involved in thelarche (GO:0060744)	NEW	8.12	0.002	ESR1, TP53, AKT1
protein processing (GO:0016485)	NEW	4.62	0.004	KRAS, ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1, TSG101
brain development (GO:0007420)	-	4.24	0.017	ATM, BRCA2, ESR1, BARD1, TP53, CDH1, AKT1, CHEK2
protein oligomerization (GO:0051259)	-	3.71	0.012	PHB, KRAS, CASP8, TP53, CDH1, RB1CC1, PIK3CA, AKT1, BRCA1, RAD51
cell cycle phase transition (GO:0044770)	-	4.24	0.048	ATM, ESR1, PPM1D, TP53, AKT1, BRCA1, CHEK2
cellular response to epidermal growth factor stimulus (GO:0071364)	NEW	6.47	0.0	TP53, BRCA1, ESR1, AKT1, CDH1
cellular response to growth factor stimulus (GO:0071363)	NEW	4.27	0.0	ATM, PHB, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, HMMR
regulation of axonogenesis (GO:0050770)	NEW	4.59	0.009	KRAS, ESR1, CDH1, RB1CC1, TP53, AKT1, PIK3CA
positive regulation of lymphocyte activation (GO:0051251)	-	4.07	0.004	ATM, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1
cellular response to organic cyclic compound (GO:0071407)	-	3.93	0.0	ATM, KRAS, AKT1, CASP8, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
negative regulation of RNA metabolic process (GO:0051253)	-	2.66	0.046	ATM, PHB, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, RAD51, ESR1, PIK3CA, BRCA1, CHEK2, TSG101
regulation of lymphocyte proliferation (GO:0050670)	NEW	4.46	0.041	ATM, KRAS, ESR1, CDH1, TP53, AKT1, PIK3CA
positive regulation of lymphocyte proliferation (GO:0050671)	NEW	4.85	0.003	ATM, KRAS, ESR1, CDH1, TP53, AKT1, PIK3CA
regulation of cytokine production (GO:0001817)	NEW	3.4	0.023	ATM, KRAS, AKT1, CASP8, TP53, CDH1, HMMR, ESR1, PIK3CA, BRCA1, TSG101
negative regulation of cell morphogenesis involved in differentiation (GO:0010771)	NEW	4.96	0.047	TP53, ESR1, AKT1, CDH1
glucose metabolic process (GO:0006006)	-	4.94	0.048	ESR1, CDH1, TP53, AKT1, PIK3CA, RAD51
regulation of response to stress (GO:0080134)	-	2.53	0.0	ATM, PHB, KRAS, AKT1, CASP8, CDH1, PPM1D, RAD51, TP53, FAM175A, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, HMMR
negative regulation of cytokine production (GO:0001818)	NEW	4.4	0.031	ATM, KRAS, ESR1, CDH1, TP53, AKT1, PIK3CA
regulation of cellular response to stress (GO:0080135)	-	3.4	0.0	ATM, PHB, AKT1, CASP8, CDH1, PPM1D, TP53, FAM175A, RB1CC1, PIK3CA, ESR1, BRCA1, RAD51
cellular response to lipopolysaccharide (GO:0071222)	NEW	4.94	0.01	ATM, ESR1, CDH1, TP53, AKT1, PIK3CA
T cell activation (GO:0042110)	NEW	4.45	0.0	ATM, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, ESR1, BRCA1, CHEK2
cellular response to acid chemical (GO:0071229)	NEW	4.67	0.026	ATM, ESR1, CDH1, RB1CC1, TP53, AKT1, BRCA1
glycerolipid biosynthetic process (GO:0045017)	-	4.53	0.0	ATM, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, TSG101
angiogenesis (GO:0001525)	NEW	4.15	0.007	ATM, KRAS, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, HMMR
response to gamma radiation (GO:0010332)	-	5.78	0.001	ATM, CHEK2, BRCA2, TP53, AKT1
organic substance metabolic process (GO:0071704)	-	0.63	0.02	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1, BRIP1, HMMR, BRCA2, RAD51, ESR1, CHEK2, TSG101
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (GO:1901028)	-	5.94	0.038	CASP8, TP53, AKT1
positive regulation of JAK-STAT cascade (GO:0046427)	NEW	5.44	0.004	TP53, ESR1, AKT1, PIK3CA, CDH1
DNA damage response, signal transduction by p53 class mediator (GO:0030330)	-	5.3	0.0	ATM, NBN, BRCA2, TP53, CDH1, ESR1, BRCA1
response to tumor necrosis factor (GO:0034612)	-	4.93	0.002	CASP8, TP53, CDH1, PIK3CA, AKT1, BRCA1, HMMR
apoptotic process (GO:0006915)	-	3.14	0.045	ATM, PHB, KRAS, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
negative regulation of cell cycle (GO:0045786)	-	3.67	0.046	ATM, NBN, KRAS, AKT1, CASP8, BARD1, PPM1D, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
negative regulation of RNA biosynthetic process (GO:1902679)	-	2.7	0.034	ATM, PHB, KRAS, AKT1, CASP8, BARD1, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
regulation of nitrogen compound metabolic process (GO:0051171)	-	1.36	0.02	PHB, NBN, KRAS, BRCA2, AKT1, CDH1, BARD1, TP53, FAM175A, RB1CC1, RAD51, ESR1, PIK3CA, BRCA1, BRIP1, CHEK2, TSG101
phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	-	5.84	0.011	ATM, AKT1, PIK3CA
positive regulation of nitrogen compound metabolic process (GO:0051173)	-	2.29	0.018	PHB, BRCA2, ESR1, TP53, FAM175A, CDH1, AKT1, BRCA1, CHEK2, RAD51
ribonucleoside metabolic process (GO:0009119)	NEW	4.21	0.038	PHB, ATM, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
macromolecule catabolic process (GO:0009057)	-	3.0	0.0	ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, PPM1D, TSG101, TP53, CDH1, RAD51, PIK3CA, ESR1, CHEK2, RAD54L, BRCA1, HMMR
DNA recombination (GO:0006310)	-	4.39	0.0	ATM, NBN, XRCC3, BRCA2, AKT1, PALB2, TP53, ESR1, CHEK2, RAD54L, BRCA1, RAD51
DNA damage checkpoint (GO:0000077)	-	5.37	0.0	ATM, NBN, PIK3CA, FAM175A, TP53, AKT1, BRCA1, BRIP1, CHEK2
cell cycle checkpoint (GO:0000075)	-	4.79	0.0	ATM, NBN, XRCC3, ESR1, TP53, FAM175A, PIK3CA, AKT1, BRCA1, BRIP1, CHEK2, RAD51
regulation of cell cycle (GO:0051726)	-	2.93	0.0	ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, PPM1D, BARD1, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
response to ketone (GO:1901654)	-	4.53	0.003	ATM, KRAS, ESR1, CDH1, TP53, AKT1, PIK3CA
mitotic G2 DNA damage checkpoint (GO:0007095)	NEW	7.24	0.036	ATM, NBN, TP53
glycosyl compound catabolic process (GO:1901658)	NEW	6.02	0.005	ATM, PHB, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
mitotic cell cycle checkpoint (GO:0007093)	-	5.31	0.0	ATM, NBN, ESR1, TP53, PIK3CA, AKT1, BRCA1, RAD51
regulation of synaptic transmission (GO:0050804)	NEW	4.09	0.046	ATM, KRAS, ESR1, BARD1, TP53, CDH1, PIK3CA, AKT1
limb morphogenesis (GO:0035108)	NEW	5.05	0.013	ESR1, CDH1, TP53, AKT1, CHEK2, BRCA1
regulation of histone acetylation (GO:0035065)	NEW	5.74	0.035	BRCA1, ESR1, TP53, AKT1
positive regulation of histone acetylation (GO:0035066)	NEW	6.33	0.001	BRCA1, ESR1, TP53, AKT1
positive regulation of alpha-beta T cell activation (GO:0046635)	NEW	5.76	0.009	ATM, BRCA1, ESR1, TP53, AKT1
appendage morphogenesis (GO:0035107)	NEW	5.05	0.013	ESR1, CDH1, TP53, AKT1, CHEK2, BRCA1
alpha-beta T cell differentiation (GO:0046632)	NEW	6.15	0.003	TP53, BRCA1, KRAS, ESR1, AKT1
alpha-beta T cell activation (GO:0046631)	NEW	5.92	0.0	ATM, ESR1, KRAS, TP53, AKT1, BRCA1
male gonad development (GO:0008584)	NEW	5.08	0.0	ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1, BRCA1, CHEK2
female gamete generation (GO:0007292)	NEW	5.99	0.001	CHEK2, BRCA2, TP53, AKT1, RAD51
membrane organization (GO:0061024)	-	3.04	0.002	ATM, PHB, KRAS, RAD51, TP53, CDH1, HMMR, AKT1, PIK3CA, BRCA1, CHEK2, TSG101
signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	-	5.59	0.038	ATM, CHEK2, ESR1, TP53
signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	-	5.59	0.038	ATM, CHEK2, ESR1, TP53
nucleobase-containing compound catabolic process (GO:0034655)	NEW	3.9	0.0	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, PPM1D, TP53, CDH1, RAD51, ESR1, PIK3CA, RAD54L, BRIP1, CHEK2, TSG101
signal transduction by phosphorylation (GO:0023014)	-	3.79	0.0	ATM, KRAS, AKT1, CASP8, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1
positive regulation of cell cycle arrest (GO:0071158)	-	5.29	0.0	ATM, ESR1, CDH1, TP53, AKT1, BRCA1
signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	-	5.59	0.038	ATM, CHEK2, ESR1, TP53
positive regulation of macromolecule metabolic process (GO:0010604)	-	1.81	0.0	NBN, PHB, KRAS, BRCA2, AKT1, CASP8, CDH1, BARD1, PIK3CA, FAM175A, RB1CC1, TP53, ESR1, BRCA1, CHEK2, RAD51
response to bacterium (GO:0009617)	NEW	4.18	0.003	AKT1, CASP8, PPM1D, RAD51, TP53, PIK3CA, ESR1, HMMR
peptidyl-amino acid modification (GO:0018193)	-	2.98	0.0	PHB, ATM, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, RAD51, ESR1, PIK3CA, BRCA1, CHEK2, TSG101
positive regulation of steroid biosynthetic process (GO:0010893)	NEW	7.16	0.049	ESR1, AKT1, CDH1
DNA replication (GO:0006260)	-	4.51	0.001	ATM, PHB, KRAS, PIK3CA, TP53, AKT1, BRCA1, RAD51
purine ribonucleoside triphosphate catabolic process (GO:0009207)	NEW	9.73	0.002	PHB, ATM, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
purine ribonucleoside triphosphate metabolic process (GO:0009205)	NEW	4.81	0.006	PHB, ATM, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
ribonucleoside triphosphate catabolic process (GO:0009203)	NEW	9.73	0.002	ATM, PHB, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
regulation of macromolecule metabolic process (GO:0060255)	-	1.08	0.006	ATM, NBN, KRAS, BRCA2, AKT1, CASP8, CDH1, BARD1, RAD51, TP53, PHB, FAM175A, RB1CC1, PIK3CA, ESR1, BRCA1, BRIP1, CHEK2, TSG101
cell differentiation involved in embryonic placenta development (GO:0060706)	-	6.59	0.0	TP53, CASP8, ESR1, AKT1, TSG101
lymphocyte activation (GO:0046649)	-	3.96	0.004	ATM, NBN, KRAS, ESR1, CASP8, TP53, CDH1, AKT1, BRCA1, CHEK2
regulation of neuron projection development (GO:0010975)	NEW	3.69	0.006	KRAS, ESR1, BARD1, PIK3CA, CDH1, RB1CC1, TP53, AKT1, BRCA1, CHEK2
intracellular steroid hormone receptor signaling pathway (GO:0030518)	-	5.47	0.005	PHB, BRCA1, ESR1, CHEK2, TP53
purine ribonucleoside metabolic process (GO:0046128)	NEW	4.33	0.025	ATM, PHB, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
platelet activation (GO:0030168)	-	4.96	0.034	KRAS, ESR1, CDH1, RB1CC1, TP53, AKT1, PIK3CA
spermatogenesis (GO:0007283)	NEW	3.7	0.003	ATM, KRAS, BRCA2, AKT1, CASP8, RAD51, TP53, CDH1, PIK3CA, ESR1, TSG101
positive regulation of oxidoreductase activity (GO:0051353)	-	5.94	0.028	TP53, KRAS, ESR1, AKT1, CDH1
aromatic compound catabolic process (GO:0019439)	NEW	3.79	0.0	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, PPM1D, TP53, CDH1, RAD51, ESR1, PIK3CA, CHEK2, RAD54L, BRIP1, BRCA1, TSG101
regulation of kidney development (GO:0090183)	NEW	5.72	0.0	ESR1, CDH1, TP53, AKT1, CHEK2, BRCA1
positive regulation of mononuclear cell proliferation (GO:0032946)	NEW	4.84	0.003	ATM, KRAS, ESR1, CDH1, TP53, AKT1, PIK3CA
regulation of mononuclear cell proliferation (GO:0032944)	NEW	4.45	0.043	ATM, KRAS, ESR1, CDH1, TP53, AKT1, PIK3CA
response to lipopolysaccharide (GO:0032496)	NEW	4.03	0.018	ATM, KRAS, ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1
regulation of mitotic cell cycle (GO:0007346)	-	3.71	0.0	ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, PPM1D, BARD1, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, TSG101
regulation of protein secretion (GO:0050708)	NEW	3.77	0.007	ATM, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, HMMR
cellular response to tumor necrosis factor (GO:0071356)	NEW	5.19	0.009	CDH1, TP53, AKT1, PIK3CA, BRCA1, HMMR
regulation of cytokine secretion (GO:0050707)	NEW	4.74	0.0	ATM, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, HMMR
gonad development (GO:0008406)	-	4.92	0.0	ATM, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2
cellular component organization (GO:0016043)	-	1.24	0.005	PHB, ATM, KRAS, BRCA2, AKT1, CASP8, CDH1, TP53, FAM175A, RB1CC1, RAD51, ESR1, NBN, CHEK2, RAD54L, BRCA1, TSG101
macromolecular complex assembly (GO:0065003)	-	2.55	0.023	PHB, ATM, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, RB1CC1, RAD51, ESR1, PIK3CA, BRCA1, CHEK2, TSG101
ribonucleotide catabolic process (GO:0009261)	NEW	6.43	0.004	PHB, ATM, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
ribonucleoside monophosphate catabolic process (GO:0009158)	NEW	8.12	0.005	PHB, ATM, BRCA2, XRCC3, TP53, ESR1, BRCA1, BRIP1, RAD51
purine ribonucleotide catabolic process (GO:0009154)	NEW	6.47	0.004	ATM, PHB, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
purine ribonucleotide metabolic process (GO:0009150)	NEW	4.16	0.044	ATM, PHB, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
regulation of cell cycle phase transition (GO:1901987)	-	4.15	0.0	ATM, NBN, BRCA2, AKT1, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
negative regulation of DNA replication (GO:0008156)	-	6.17	0.0	ATM, CHEK2, BRCA2, TP53, CDH1
positive regulation of protein acetylation (GO:1901985)	NEW	6.15	0.004	BRCA1, ESR1, TP53, AKT1
metabolic process (GO:0008152)	-	0.58	0.033	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1, BRIP1, HMMR, BRCA2, NQO2, RAD51, ESR1, CHEK2, TSG101
heart development (GO:0007507)	-	4.24	0.003	ATM, ESR1, CASP8, CDH1, RB1CC1, TP53, AKT1, CHEK2
negative regulation of cell cycle phase transition (GO:1901988)	-	4.74	0.0	ATM, NBN, ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1, CHEK2, RAD51
regulation of phosphatidylinositol 3-kinase activity (GO:0043551)	NEW	6.02	0.009	TP53, ESR1, AKT1, PIK3CA
regulation of lipid kinase activity (GO:0043550)	NEW	5.84	0.029	TP53, AKT1, ESR1, PIK3CA
cellular response to nitrogen compound (GO:1901699)	-	3.79	0.01	ATM, KRAS, AKT1, CASP8, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, RAD51
positive regulation of protein catabolic process (GO:0045732)	-	4.18	0.023	ESR1, BARD1, CDH1, TP53, AKT1, PIK3CA
positive regulation of myeloid cell differentiation (GO:0045639)	NEW	5.33	0.0	KRAS, ESR1, CASP8, CDH1, TP53, AKT1, BRCA1
response to fibroblast growth factor (GO:0071774)	NEW	6.17	0.014	KRAS, ESR1, CDH1, TP53, AKT1, PIK3CA, CHEK2
regulation of myeloid cell differentiation (GO:0045637)	NEW	4.56	0.035	KRAS, ESR1, CASP8, CDH1, TP53, AKT1, BRCA1
negative regulation of cell growth (GO:0030308)	-	4.58	0.002	PHB, KRAS, AKT1, TP53, TSG101, ESR1, BRCA1, HMMR
dephosphorylation (GO:0016311)	NEW	4.06	0.022	ATM, CASP8, PPM1D, TP53, CDH1, AKT1, CHEK2, RAD51
tube formation (GO:0035148)	NEW	4.98	0.002	ESR1, CASP8, CDH1, TP53, AKT1, BRCA1, CHEK2
negative regulation of signaling (GO:0023057)	-	2.65	0.045	PHB, ESR1, CASP8, TP53, RB1CC1, CDH1, AKT1, BRCA1
purine nucleoside monophosphate catabolic process (GO:0009128)	NEW	7.94	0.005	PHB, ATM, BRCA2, XRCC3, TP53, ESR1, BRCA1, BRIP1, RAD51
positive regulation of nitric-oxide synthase activity (GO:0051000)	-	6.78	0.029	ESR1, KRAS, AKT1
negative regulation of cell communication (GO:0010648)	-	2.66	0.046	PHB, ESR1, CASP8, TP53, RB1CC1, CDH1, AKT1, BRCA1
axon guidance (GO:0007411)	NEW	4.44	0.001	ATM, KRAS, ESR1, TP53, CDH1, RB1CC1, PIK3CA, AKT1, BRCA1, CHEK2, RAD51
mitotic cell cycle phase transition (GO:0044772)	-	4.27	0.046	ATM, ESR1, PPM1D, TP53, AKT1, BRCA1, CHEK2
purine nucleoside monophosphate metabolic process (GO:0009126)	NEW	4.69	0.003	PHB, ATM, XRCC3, BRCA2, AKT1, TP53, ESR1, BRCA1, BRIP1, RAD51
nucleoside monophosphate catabolic process (GO:0009125)	NEW	7.65	0.006	PHB, ATM, BRCA2, XRCC3, TP53, ESR1, BRCA1, BRIP1, RAD51
telomere maintenance (GO:0000723)	-	5.37	0.049	ATM, NBN, TP53, XRCC3
recombinational repair (GO:0000725)	-	5.37	0.0	ATM, NBN, BRCA2, PALB2, XRCC3, BRCA1, RAD54L, RAD51
double-strand break repair via homologous recombination (GO:0000724)	-	5.38	0.0	ATM, NBN, BRCA2, PALB2, XRCC3, BRCA1, RAD54L, RAD51
regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway (GO:1900739)	-	6.33	0.011	CASP8, TP53, AKT1
primary metabolic process (GO:0044238)	-	0.69	0.011	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1, BRIP1, HMMR, BRCA2, RAD51, ESR1, CHEK2, TSG101
positive regulation of cell differentiation (GO:0045597)	-	3.01	0.002	ATM, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
negative regulation of transcription, DNA-templated (GO:0045892)	-	2.75	0.029	ATM, PHB, KRAS, AKT1, CASP8, BARD1, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
response to acid chemical (GO:0001101)	NEW	4.05	0.03	ATM, ESR1, TP53, CDH1, RB1CC1, PIK3CA, AKT1, BRCA1, RAD51
positive regulation of NF-kappaB transcription factor activity (GO:0051092)	NEW	4.85	0.013	ESR1, CASP8, TP53, CDH1, KRAS, AKT1
negative regulation of cellular protein metabolic process (GO:0032269)	-	2.88	0.0	ATM, KRAS, BRCA2, AKT1, CASP8, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, HMMR
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090)	-	3.83	0.036	ATM, PHB, KRAS, ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1
aging (GO:0007568)	-	4.16	0.0	ATM, BRCA2, AKT1, CASP8, TP53, RB1CC1, CDH1, ESR1, BRCA1, CHEK2
intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630)	-	5.44	0.0	ATM, BRCA2, CASP8, TP53, AKT1, BRCA1, CHEK2
positive regulation of developmental process (GO:0051094)	-	2.77	0.027	ATM, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
monosaccharide metabolic process (GO:0005996)	-	4.57	0.003	KRAS, ESR1, TP53, CDH1, TSG101, AKT1, PIK3CA, RAD51
macromolecule metabolic process (GO:0043170)	-	0.83	0.001	ATM, PALB2, TP53, FAM175A, RB1CC1, XRCC3, RAD54L, PHB, CASP8, PPM1D, PIK3CA, BRCA1, NBN, BARD1, CDH1, AKT1, BRIP1, HMMR, BRCA2, TSG101, ESR1, CHEK2, RAD51
positive regulation of proteolysis (GO:0045862)	-	3.86	0.002	ESR1, CASP8, CDH1, TP53, AKT1, PIK3CA
glycerophospholipid metabolic process (GO:0006650)	-	4.13	0.003	ATM, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1
positive regulation of histone H3-K9 acetylation (GO:2000617)	NEW	7.65	0.024	BRCA1, TP53
positive regulation of cellular metabolic process (GO:0031325)	-	1.81	0.0	PHB, NBN, KRAS, BRCA2, AKT1, CASP8, CDH1, TP53, FAM175A, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
mitotic cell cycle process (GO:1903047)	-	3.12	0.0	ATM, NBN, ESR1, PPM1D, BARD1, RAD51, TP53, CDH1, PIK3CA, AKT1, BRCA1, CHEK2, TSG101
nucleic acid metabolic process (GO:0090304)	-	1.46	0.002	ATM, NBN, BRCA2, XRCC3, PALB2, BARD1, TP53, PHB, FAM175A, RB1CC1, ESR1, AKT1, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
negative regulation of cell cycle process (GO:0010948)	-	4.37	0.0	ATM, NBN, ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1, CHEK2, RAD51
positive regulation of cell death (GO:0010942)	-	3.32	0.008	ATM, PHB, KRAS, AKT1, CASP8, PPM1D, BARD1, TP53, CDH1, PIK3CA, ESR1
regulation of cell death (GO:0010941)	-	2.43	0.0	ATM, PHB, KRAS, AKT1, CASP8, PALB2, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1
mitotic nuclear division (GO:0007067)	NEW	4.05	0.004	ATM, TP53, CDH1, RAD51, AKT1, BRCA1, CHEK2, TSG101
negative regulation of transcription by competitive promoter binding (GO:0010944)	NEW	7.43	0.015	PHB, TP53, CDH1
intracellular receptor signaling pathway (GO:0030522)	-	4.6	0.001	PHB, AKT1, CASP8, TP53, ESR1, BRCA1, CHEK2, TSG101
cellular response to organonitrogen compound (GO:0071417)	-	3.87	0.029	ATM, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, RAD51
regulation of mesenchymal cell proliferation (GO:0010464)	NEW	6.17	0.003	TP53, CHEK2, ESR1, AKT1, CDH1
gene expression (GO:0010467)	NEW	5.8	0.046	ATM, PHB, KRAS, AKT1, RAD51, TP53, PIK3CA, ESR1, BRCA1, TSG101
purine nucleoside catabolic process (GO:0006152)	NEW	7.16	0.003	PHB, ATM, XRCC3, KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRIP1, RAD51
RNA catabolic process (GO:0006401)	NEW	4.3	0.05	ATM, CASP8, PPM1D, TP53, AKT1, RAD51
hematopoietic or lymphoid organ development (GO:0048534)	NEW	4.49	0.0	KRAS, BRCA2, ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1, CHEK2
positive regulation of T cell proliferation (GO:0042102)	NEW	5.16	0.006	ATM, CASP8, TP53, KRAS, CDH1, AKT1
stress-activated MAPK cascade (GO:0051403)	NEW	5.45	0.001	ATM, CASP8, KRAS, RB1CC1, TP53, AKT1
DNA damage response, signal transduction resulting in transcription (GO:0042772)	-	7.02	0.0	BRCA1, BRCA2, TP53, CDH1
signal transduction in response to DNA damage (GO:0042770)	-	5.15	0.0	ATM, NBN, BRCA2, BARD1, TP53, CDH1, ESR1, BRCA1, CHEK2
inner ear morphogenesis (GO:0042472)	NEW	5.62	0.035	TP53, BRCA1, ESR1, CHEK2, AKT1
odontogenesis of dentin-containing tooth (GO:0042475)	NEW	5.52	0.002	ATM, ESR1, CDH1, TP53, AKT1, CHEK2
stress-activated protein kinase signaling cascade (GO:0031098)	NEW	5.41	0.001	ATM, CASP8, KRAS, RB1CC1, TP53, AKT1
odontogenesis (GO:0042476)	NEW	5.19	0.001	ATM, ESR1, CDH1, RB1CC1, TP53, AKT1, CHEK2
replicative senescence (GO:0090399)	-	7.24	0.001	ATM, CHEK2, TP53, AKT1
regulation of leukocyte proliferation (GO:0070663)	NEW	4.4	0.048	ATM, KRAS, ESR1, CDH1, TP53, AKT1, PIK3CA
organelle fission (GO:0048285)	-	3.79	0.0	ATM, NBN, BRCA2, BARD1, TP53, CDH1, RAD51, AKT1, CHEK2, BRCA1, RAD54L, TSG101
viral process (GO:0016032)	-	3.15	0.037	PHB, KRAS, AKT1, CASP8, RAD51, TP53, HMMR, ESR1, PIK3CA, BRCA1, TSG101
immune effector process (GO:0002252)	-	3.58	0.029	ATM, NBN, KRAS, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, HMMR
negative regulation of protein phosphorylation (GO:0001933)	-	3.79	0.001	ATM, KRAS, AKT1, CASP8, TP53, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
regulation of protein phosphorylation (GO:0001932)	-	2.57	0.001	PHB, ATM, KRAS, NBN, AKT1, CASP8, PPM1D, TP53, CDH1, RB1CC1, RAD51, ESR1, PIK3CA, BRCA1, CHEK2, HMMR
positive regulation of protein phosphorylation (GO:0001934)	-	2.95	0.0	ATM, NBN, KRAS, AKT1, CASP8, PPM1D, TP53, PHB, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
intracellular part (GO:0044424)	0.28	26	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, SLC22A18, BARD1, CDH1, AKT1, BRIP1, HMMR, BRCA2, NQO2, RAD51, ESR1, CHEK2, TSG101
cell part (GO:0044464)	0.11	26	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, SLC22A18, BARD1, CDH1, AKT1, BRIP1, HMMR, BRCA2, NQO2, RAD51, ESR1, CHEK2, TSG101
membrane-bounded organelle (GO:0043227)	0.47	23	ATM, PALB2, TP53, FAM175A, RB1CC1, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1, BRIP1, BRCA2, NQO2, RAD51, ESR1, CHEK2, TSG101
organelle (GO:0043226)	0.4	23	ATM, PALB2, TP53, FAM175A, RB1CC1, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1, BRIP1, BRCA2, NQO2, RAD51, ESR1, CHEK2, TSG101
intracellular organelle part (GO:0044446)	0.81	22	ATM, PALB2, TP53, FAM175A, RB1CC1, XRCC3, RAD54L, PHB, CASP8, BRCA1, NBN, SLC22A18, BARD1, CDH1, AKT1, BRIP1, BRCA2, NQO2, TSG101, ESR1, CHEK2, RAD51
intracellular organelle (GO:0043229)	0.51	22	ATM, PALB2, TP53, FAM175A, RB1CC1, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1, BRIP1, BRCA2, TSG101, ESR1, CHEK2, RAD51
intracellular membrane-bounded organelle (GO:0043231)	0.6	22	ATM, PALB2, TP53, FAM175A, RB1CC1, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1, BRIP1, BRCA2, TSG101, ESR1, CHEK2, RAD51
organelle part (GO:0044422)	0.79	22	ATM, PALB2, TP53, FAM175A, RB1CC1, XRCC3, RAD54L, PHB, CASP8, BRCA1, NBN, SLC22A18, BARD1, CDH1, AKT1, BRIP1, BRCA2, NQO2, TSG101, ESR1, CHEK2, RAD51
nuclear part (GO:0044428)	1.55	21	PHB, ATM, SLC22A18, BRCA2, AKT1, CASP8, PALB2, BARD1, RAD51, TP53, FAM175A, RB1CC1, XRCC3, NQO2, ESR1, NBN, CHEK2, BRCA1, BRIP1, RAD54L, TSG101
cytoplasm (GO:0005737)	1.01	19	PHB, ATM, SLC22A18, KRAS, BRCA2, AKT1, CASP8, BARD1, RAD51, TP53, CDH1, RB1CC1, XRCC3, NQO2, ESR1, BRCA1, BRIP1, TSG101, HMMR
nucleus (GO:0005634)	1.07	19	PHB, ATM, XRCC3, BRCA2, AKT1, PPM1D, PALB2, BARD1, TP53, FAM175A, RB1CC1, RAD51, ESR1, NBN, CHEK2, BRCA1, BRIP1, RAD54L, TSG101
nucleoplasm (GO:0005654)	1.89	18	PHB, ATM, XRCC3, BRCA2, AKT1, CASP8, PALB2, BARD1, TP53, FAM175A, NQO2, ESR1, NBN, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
cytoplasmic part (GO:0044444)	0.82	18	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, RAD51, TP53, CDH1, RB1CC1, TSG101, ESR1, PIK3CA, NBN, BRCA1, CHEK2, HMMR
macromolecular complex (GO:0032991)	1.35	16	ATM, NBN, XRCC3, BRCA2, AKT1, CASP8, CDH1, BARD1, TP53, FAM175A, RB1CC1, RAD51, ESR1, PIK3CA, BRCA1, TSG101
protein complex (GO:0043234)	1.51	15	ATM, NBN, XRCC3, BRCA2, AKT1, CASP8, CDH1, BARD1, TP53, FAM175A, RB1CC1, PIK3CA, ESR1, BRCA1, TSG101
membrane (GO:0016020)	0.68	15	PHB, SLC22A18, KRAS, BRCA2, AKT1, CASP8, TSG101, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, BRIP1, HMMR
membrane part (GO:0044425)	0.95	11	PHB, SLC22A18, KRAS, BRCA2, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, TSG101
non-membrane-bounded organelle (GO:0043228)	1.76	10	ATM, NBN, BRCA2, CASP8, TP53, CDH1, RAD51, AKT1, BRCA1, TSG101
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	10	ATM, NBN, BRCA2, CASP8, TP53, CDH1, RAD51, AKT1, BRCA1, TSG101
plasma membrane (GO:0005886)	1.39	10	PHB, SLC22A18, KRAS, AKT1, PIK3CA, CDH1, TSG101, ESR1, BRCA1, HMMR
cytosol (GO:0005829)	1.68	8	NBN, KRAS, CASP8, TP53, RB1CC1, PIK3CA, AKT1, HMMR
chromosomal part (GO:0044427)	3.18	8	ATM, NBN, BRCA2, XRCC3, TP53, ESR1, CHEK2, RAD51
mitochondrion (GO:0005739)	2.42	8	PHB, XRCC3, ESR1, CASP8, TP53, KRAS, AKT1, RAD51
nuclear chromosome part (GO:0044454)	3.67	7	ATM, NBN, BRCA2, XRCC3, TP53, ESR1, RAD51
integral component of membrane (GO:0016021)	1.14	7	PHB, SLC22A18, BRCA2, TP53, CDH1, ESR1, BRCA1
cytoskeletal part (GO:0044430)	2.49	7	ATM, BRCA2, CASP8, CDH1, AKT1, BRCA1, RAD51
vesicle (GO:0031982)	1.64	7	PHB, ATM, BRCA2, NQO2, CDH1, AKT1, TSG101
intrinsic component of membrane (GO:0031224)	1.13	7	PHB, SLC22A18, BRCA2, TP53, CDH1, ESR1, BRCA1
chromosome, telomeric region (GO:0000781)	4.9	6	ATM, NBN, BRCA2, XRCC3, CHEK2, RAD51
plasma membrane part (GO:0044459)	1.95	6	PHB, SLC22A18, CASP8, KRAS, CDH1, ESR1
chromosomal region (GO:0098687)	4.19	6	ATM, NBN, BRCA2, XRCC3, CHEK2, RAD51
membrane-bounded vesicle (GO:0031988)	1.71	6	PHB, ATM, BRCA2, CDH1, NQO2, TSG101
nuclear chromosome, telomeric region (GO:0000784)	5.16	5	ATM, NBN, BRCA2, RAD51, XRCC3
cytoskeleton (GO:0005856)	2.55	5	RAD51, CASP8, BRCA2, AKT1, CDH1
catalytic complex (GO:1902494)	2.9	5	BRCA1, CASP8, BARD1, RB1CC1, PIK3CA
organelle membrane (GO:0031090)	1.97	5	PHB, RB1CC1, BRIP1, CASP8, TSG101
mitochondrial part (GO:0044429)	2.92	5	PHB, BRCA1, CASP8, RAD51, TP53
PML body (GO:0016605)	5.24	4	NBN, CHEK2, RAD51, TP53
nuclear body (GO:0016604)	3.94	4	NBN, CHEK2, RAD51, TP53
extracellular organelle (GO:0043230)	1.89	4	PHB, CDH1, NQO2, TSG101
extracellular exosome (GO:0070062)	1.89	4	PHB, CDH1, NQO2, TSG101
nucleolus (GO:0005730)	3.06	4	NBN, RAD51, TP53, TSG101
extracellular vesicle (GO:1903561)	1.89	4	PHB, TSG101, CDH1, NQO2
microtubule organizing center (GO:0005815)	3.42	4	RAD51, BRCA2, CASP8, AKT1
membrane protein complex (GO:0098796)	2.84	4	CASP8, TSG101, CDH1, PIK3CA
nucleoplasm part (GO:0044451)	3.22	4	NBN, CHEK2, RAD51, TP53
transferase complex (GO:1990234)	3.32	4	BRCA1, BARD1, RB1CC1, PIK3CA
perinuclear region of cytoplasm (GO:0048471)	3.35	4	ESR1, RAD51, XRCC3, CDH1
cell projection (GO:0042995)	2.47	4	CASP8, ESR1, PIK3CA, CDH1
extracellular region part (GO:0044421)	1.57	4	PHB, TSG101, CDH1, NQO2
Golgi apparatus (GO:0005794)	2.7	3	CHEK2, ESR1, CDH1
organelle lumen (GO:0043233)	3.05	3	BRCA1, RAD51, TP53
vacuole (GO:0005773)	2.92	3	PHB, CDH1, TSG101
endosome (GO:0005768)	3.25	3	PHB, TSG101, CDH1
whole membrane (GO:0098805)	2.85	3	RB1CC1, CASP8, TSG101
intracellular organelle lumen (GO:0070013)	3.05	3	BRCA1, RAD51, TP53
membrane-enclosed lumen (GO:0031974)	3.05	3	BRCA1, RAD51, TP53
mitochondrial matrix (GO:0005759)	4.03	3	BRCA1, RAD51, TP53
replication fork (GO:0005657)	6.62	3	NBN, TP53, XRCC3
chromatin (GO:0000785)	3.99	3	ESR1, RAD51, TP53
BRCA1-A complex (GO:0070531)	7.86	3	FAM175A, BRCA1, BARD1
chromosome (GO:0005694)	3.78	3	NBN, BRCA1, RAD51
cell junction (GO:0030054)	2.75	3	KRAS, AKT1, CDH1
membrane raft (GO:0045121)	4.18	2	KRAS, CASP8
cell-cell junction (GO:0005911)	3.85	2	AKT1, CDH1
inclusion body (GO:0016234)	5.55	2	NBN, CDH1
nuclear chromosome (GO:0000228)	5.55	2	BRCA1, RAD51
focal adhesion (GO:0005925)	3.83	2	KRAS, CDH1
cell-substrate adherens junction (GO:0005924)	3.83	2	KRAS, CDH1
cell-substrate junction (GO:0030055)	3.82	2	KRAS, CDH1
spindle (GO:0005819)	4.52	2	ATM, AKT1
BRCA1-BARD1 complex (GO:0031436)	9.11	2	BRCA1, BARD1
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	2	ATM, BRCA2
cytoplasmic vesicle (GO:0031410)	2.87	2	ATM, BRCA2
neuron part (GO:0097458)	2.64	2	ESR1, CASP8
synapse part (GO:0044456)	3.42	2	ESR1, AKT1
neuron projection (GO:0043005)	3.12	2	ESR1, CASP8
cell surface (GO:0009986)	3.44	2	PHB, HMMR
membrane region (GO:0098589)	3.95	2	KRAS, CASP8
transferase complex, transferring phosphorus-containing groups (GO:0061695)	4.61	2	RB1CC1, PIK3CA
lamellipodium (GO:0030027)	4.73	2	PIK3CA, CDH1
bounding membrane of organelle (GO:0098588)	2.39	2	CASP8, TSG101
anchoring junction (GO:0070161)	3.61	2	KRAS, CDH1
nuclear membrane (GO:0031965)	4.2	2	RB1CC1, BRIP1
mitochondrial membrane (GO:0031966)	3.31	2	PHB, CASP8
condensed chromosome (GO:0000793)	5.64	2	BRCA1, RAD51
nuclear chromatin (GO:0000790)	4.42	2	ESR1, TP53
adherens junction (GO:0005912)	3.66	2	KRAS, CDH1
condensed nuclear chromosome (GO:0000794)	6.11	2	BRCA1, RAD51
site of double-strand break (GO:0035861)	6.37	2	NBN, RAD51
cell projection part (GO:0044463)	2.97	2	ESR1, AKT1
ubiquitin ligase complex (GO:0000151)	4.23	2	BRCA1, BARD1
nuclear ubiquitin ligase complex (GO:0000152)	6.06	2	BRCA1, BARD1
intracellular (GO:0005622)	2.37	2	KRAS, PIK3CA
plasma membrane protein complex (GO:0098797)	3.55	2	CASP8, CDH1
membrane microdomain (GO:0098857)	4.17	2	KRAS, CASP8
early endosome (GO:0005769)	4.34	2	PHB, TSG101
intracellular vesicle (GO:0097708)	2.86	2	ATM, BRCA2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
replication fork (GO:0005657)	-	6.62	0.001	NBN, TP53, XRCC3
organelle envelope lumen (GO:0031970)	NEW	5.41	0.028	TP53, ESR1, KRAS, AKT1
intracellular non-membrane-bounded organelle (GO:0043232)	-	1.76	0.025	ATM, NBN, BRCA2, CASP8, BARD1, TP53, CDH1, RAD51, AKT1, BRCA1, TSG101
extracellular matrix (GO:0031012)	NEW	3.81	0.007	PHB, KRAS, ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1
endocytic vesicle (GO:0030139)	NEW	5.04	0.001	TSG101, KRAS, TP53, AKT1, PIK3CA, RAD51
non-membrane-bounded organelle (GO:0043228)	-	1.76	0.025	ATM, NBN, BRCA2, CASP8, BARD1, TP53, CDH1, RAD51, AKT1, BRCA1, TSG101
chromatin (GO:0000785)	-	3.99	0.0	ATM, NBN, AKT1, CASP8, TP53, CDH1, ESR1, RAD54L, BRCA1, TSG101
cell-substrate adherens junction (GO:0005924)	-	3.83	0.014	KRAS, ESR1, CASP8, TP53, CDH1, HMMR, AKT1, RAD51
focal adhesion (GO:0005925)	-	3.83	0.011	KRAS, ESR1, CASP8, TP53, CDH1, HMMR, AKT1, RAD51
cell-substrate junction (GO:0030055)	-	3.82	0.014	KRAS, ESR1, CASP8, TP53, CDH1, HMMR, AKT1, RAD51
cytoskeleton (GO:0005856)	-	2.55	0.011	ATM, KRAS, AKT1, CASP8, BARD1, RAD51, TP53, CDH1, HMMR, ESR1, CHEK2, TSG101
PML body (GO:0016605)	-	5.24	0.001	ATM, NBN, ESR1, TP53, AKT1, CHEK2, RAD51
nuclear body (GO:0016604)	-	3.94	0.0	ATM, NBN, KRAS, ESR1, TP53, RAD51, AKT1, BRCA1, CHEK2, TSG101
BRCA1-BARD1 complex (GO:0031436)	-	9.11	0.0	BRCA1, BARD1
nucleolus (GO:0005730)	-	3.06	0.0	ATM, NBN, BRCA2, ESR1, CASP8, BARD1, RAD51, TP53, PHB, CDH1, PIK3CA, AKT1, BRCA1, CHEK2, TSG101
cytoplasmic membrane-bounded vesicle (GO:0016023)	-	3.12	0.0	ATM, KRAS, BRCA2, AKT1, CASP8, PPM1D, BARD1, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, TSG101
cytoplasmic vesicle (GO:0031410)	-	2.87	0.0	ATM, KRAS, BRCA2, AKT1, CASP8, BARD1, PPM1D, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, TSG101
nucleus (GO:0005634)	-	1.07	0.008	PHB, ATM, XRCC3, BRCA2, AKT1, CASP8, PPM1D, PALB2, BARD1, TP53, FAM175A, NQO2, ESR1, NBN, BRCA1, BRIP1, RAD54L, RAD51
mitochondrion (GO:0005739)	-	2.42	0.0	PHB, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, PPM1D, TP53, CDH1, RAD51, ESR1, PIK3CA, BRCA1, BRIP1, TSG101
microtubule organizing center (GO:0005815)	-	3.42	0.001	ATM, BRCA2, CASP8, BARD1, TP53, CDH1, RAD51, AKT1, BRCA1, CHEK2, TSG101
nucleoplasm (GO:0005654)	-	1.89	0.0	ATM, PHB, XRCC3, BRCA2, AKT1, CASP8, PPM1D, PALB2, BARD1, TP53, CDH1, RAD51, ESR1, PIK3CA, NBN, BRCA1, BRIP1, CHEK2, TSG101
nuclear chromosome part (GO:0044454)	-	3.67	0.0	ATM, NBN, BRCA2, AKT1, CASP8, TP53, CDH1, RAD51, ESR1, BRCA1, TSG101
cytoskeletal part (GO:0044430)	-	2.49	0.004	ATM, KRAS, BRCA2, AKT1, CASP8, PPM1D, BARD1, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, HMMR, CHEK2, TSG101
nucleoplasm part (GO:0044451)	-	3.22	0.0	ATM, NBN, KRAS, AKT1, BARD1, TP53, RAD51, ESR1, BRCA1, BRIP1, CHEK2, TSG101
BRCA1-A complex (GO:0070531)	-	7.86	0.0	FAM175A, BRCA1, BARD1
perinuclear region of cytoplasm (GO:0048471)	-	3.35	0.014	ATM, XRCC3, KRAS, ESR1, RAD51, TP53, CDH1, TSG101, AKT1, CHEK2, HMMR
endosome membrane (GO:0010008)	NEW	3.83	0.004	ATM, KRAS, CASP8, TP53, CDH1, PIK3CA, AKT1, CHEK2, TSG101
chromosome (GO:0005694)	-	3.78	0.007	ATM, NBN, BRCA2, TP53, BRCA1, RAD51
cytoplasm (GO:0005737)	-	1.01	0.0	PHB, ATM, SLC22A18, BRCA2, AKT1, CASP8, BARD1, RAD51, TP53, CDH1, RB1CC1, XRCC3, NQO2, ESR1, BRCA1, BRIP1, TSG101, HMMR
microtubule cytoskeleton (GO:0015630)	NEW	4.78	0.002	ATM, ESR1, BARD1, TP53, AKT1, CHEK2
catalytic complex (GO:1902494)	-	2.9	0.0	ATM, NBN, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, RAD51, ESR1, PIK3CA, BRCA1, CHEK2, TSG101
nuclear membrane (GO:0031965)	-	4.2	0.001	ATM, ESR1, TP53, RB1CC1, AKT1, BRCA1, BRIP1, RAD51
nuclear chromatin (GO:0000790)	-	4.42	0.001	NBN, ESR1, CASP8, TP53, CDH1, AKT1, TSG101
mitotic spindle (GO:0072686)	NEW	6.09	0.026	ESR1, TP53, CDH1
adherens junction (GO:0005912)	-	3.66	0.044	KRAS, ESR1, CASP8, TP53, CDH1, HMMR, AKT1, RAD51
transferase complex (GO:1990234)	-	3.32	0.0	ATM, NBN, KRAS, ESR1, BARD1, TP53, CDH1, PIK3CA, AKT1, BRCA1, RAD51
extracellular space (GO:0005615)	NEW	2.63	0.006	ATM, PHB, KRAS, AKT1, CASP8, RAD51, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101, NQO2
protein complex (GO:0043234)	-	1.51	0.011	ATM, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, PHB, CASP8, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1, BRIP1, HMMR, BRCA2, NQO2, TSG101, ESR1, CHEK2, RAD51
macromolecular complex (GO:0032991)	-	1.35	0.01	ATM, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1, BRIP1, HMMR, BRCA2, NQO2, TSG101, ESR1, CHEK2, RAD51
intracellular membrane-bounded organelle (GO:0043231)	-	0.6	0.03	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, PPM1D, PALB2, CDH1, BARD1, RAD51, TP53, FAM175A, NQO2, ESR1, NBN, RAD54L, BRIP1, BRCA1, TSG101
perichromatin fibrils (GO:0005726)	NEW	8.7	0.008	BRCA1, TP53
spindle (GO:0005819)	-	4.52	0.0	ATM, ESR1, CDH1, TP53, AKT1, BRCA1, CHEK2
pronucleus (GO:0045120)	NEW	7.03	0.004	ATM, TP53, AKT1
midbody (GO:0030496)	NEW	4.95	0.009	CDH1, CHEK2, BARD1, AKT1, TSG101
ubiquitin ligase complex (GO:0000151)	-	4.23	0.001	ATM, BARD1, CDH1, TP53, ESR1, BRCA1
nuclear ubiquitin ligase complex (GO:0000152)	-	6.06	0.018	BRCA1, BARD1, CDH1
intracellular organelle part (GO:0044446)	-	0.81	0.004	ATM, PHB, SLC22A18, BRCA2, AKT1, CASP8, PALB2, CDH1, BARD1, TP53, FAM175A, RB1CC1, XRCC3, RAD51, ESR1, NBN, BRCA1, BRIP1, CHEK2, TSG101
cytosolic part (GO:0044445)	NEW	4.34	0.0	KRAS, ESR1, CASP8, TP53, PIK3CA, AKT1, BRCA1, RAD51
nuclear part (GO:0044428)	-	1.55	0.0	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, SLC22A18, BARD1, CDH1, AKT1, BRIP1, BRCA2, RAD51, ESR1, CHEK2, TSG101
organelle membrane (GO:0031090)	-	1.97	0.016	ATM, NBN, KRAS, AKT1, CASP8, BARD1, PPM1D, TSG101, TP53, PHB, CDH1, RB1CC1, RAD51, PIK3CA, ESR1, BRCA1, BRIP1, CHEK2, HMMR
endosomal part (GO:0044440)	NEW	3.73	0.006	ATM, KRAS, CASP8, TP53, CDH1, PIK3CA, AKT1, CHEK2, TSG101
centrosome (GO:0005813)	NEW	3.75	0.026	ATM, BRCA2, BARD1, TP53, CDH1, AKT1, BRCA1, TSG101
intracellular part (GO:0044424)	-	0.28	0.028	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, SLC22A18, BARD1, CDH1, AKT1, BRIP1, HMMR, BRCA2, NQO2, RAD51, ESR1, CHEK2, TSG101
chromosomal part (GO:0044427)	-	3.18	0.0	ATM, NBN, XRCC3, BRCA2, AKT1, CASP8, TP53, CDH1, RAD51, ESR1, RAD54L, BRCA1, TSG101
endosome (GO:0005768)	-	3.25	0.025	KRAS, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, TSG101
early endosome (GO:0005769)	-	4.34	0.019	ESR1, TP53, CDH1, KRAS, AKT1, TSG101
organelle part (GO:0044422)	-	0.79	0.007	ATM, NBN, SLC22A18, BRCA2, XRCC3, CASP8, PALB2, CDH1, BARD1, TP53, PHB, FAM175A, RB1CC1, RAD51, AKT1, BRCA1, ESR1, BRIP1, CHEK2, TSG101