Disease table of BREAST CANCER OMIM ID: 114480

Gene-disease associations table

GeneAssociated with BREAST CANCER inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
TSG101OMIMHGNC link11p15.11114480
HMMROMIMHGNC link5q341114480
ATMOMIMHGNC link11q22.32208900, 114480
NQO2OMIMHGNC link6p25.21114480
AKT1OMIM, HUMSAVARHGNC link14q32.336167000, 176920, 114480, 181500, 114500, PS158350
BRIP1OMIM, HUMSAVARHGNC link17q23.22PS227650, 114480
XRCC3OMIMHGNC link14q32.332PS155600, 114480
RB1CC1OMIMHGNC link8q11.231114480
PPM1DOMIMHGNC link17q23.21114480
RAD54LOMIMHGNC link1p34.12605027, 114480
FAM175AHUMSAVARHGNC link4q21.231114480
NBNHUMSAVARHGNC link8q21.34609135, 613065, 114480, 251260
CDH1OMIMHGNC link16q22.15608089, 167000, 176807, 137215, 114480
CHEK2OMIM, HUMSAVARHGNC link22q12.14PS151623, 176807, 259500, 114480
BRCA1HUMSAVARHGNC link17q21.315PS227650, 167000, 614320, PS604370, 114480
BRCA2OMIM, HUMSAVARHGNC link13q13.18PS227650, PS194070, 155255, 114480, 176807, PS137800, 613347, PS604370
BARD1OMIMHGNC link2q351114480
BCPROMIMHGNC link17-1114480
KRASOMIMHGNC link12p12.114601626, 600268, 137215, 109800, PS163950, 211980, 114480, PS115150, 613659, 163200, 607785, 614470, 162900, 260350
TP53OMIMHGNC link17p13.112114550, 260500, 605027, PS137800, 614740, 114480, 260350, 607107, 202300, 114500, PS151623, 259500
SLC22A18OMIMHGNC link11p15.43114480, 268210, 211980
ESR1OMIMHGNC link6q25.14608446, 157300, 615363, 114480
PHBOMIMHGNC link17q21.331114480
PALB2OMIMHGNC link16p12.23PS227650, 114480, 613348
CASP8OMIMHGNC link2q33.14114550, 607271, 211980, 114480
RAD51OMIM, HUMSAVARHGNC link15q15.12PS157600, 114480
PIK3CAOMIM, HUMSAVARHGNC link3q26.3211114550, PS158350, 167000, 612918, 211980, 114480, 602501, 114500, 182000, 162900, 613659

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
17q23.22BRIP1, PPM1D
14q32.332AKT1, XRCC3
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
17q212BRCA1, PHB
14q322AKT1, XRCC3
17q232BRIP1, PPM1D
11p152TSG101, SLC22A18
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
17q24BRCA1, BRIP1, PPM1D, PHB
2q32BARD1, CASP8
11p12TSG101, SLC22A18
14q32AKT1, XRCC3
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
2q2BARD1, CASP8
14q2AKT1, XRCC3
11p2TSG101, SLC22A18
8q2RB1CC1, NBN
17q4BRCA1, BRIP1, PPM1D, PHB
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
113TSG101, SLC22A18, ATM
142AKT1, XRCC3
175BRCA1, TP53, BRIP1, PPM1D, PHB
162CDH1, PALB2
22BARD1, CASP8
62NQO2, ESR1
82RB1CC1, NBN
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
TSG101YES3REG4, EGFR, MDM20
ATMYES21PVR, SP1, CDKN1A, BAX, MCL1, FOXM1, BCL2, FAS, TERF1, IGF1R, TNFRSF10B, SLC2A1, TP53, GADD45A, KLRK1, PMAIP1, DUSP1, CFLAR, VEGFA, HIPK2, MTF11TP53
BRIP1YES1BARD11BARD1
RB1CC1YES1RB10
BRCA1YES52ATM, RNASEL, DDIT3, KRT5, JAK2, MAD2L1, IRF7, EGFR, HSPA5, FOS, XPC, STAT2, EGR1, CCND1, AREG, FST, HNRNPA2B1, STAT1, CASR, E2F6, ESR1, SIRT1, DDB2, CDKN1A, KRT18, CXCL1, FOXC1, FOXC2, IFNA1, CDH3, CYP1A1, CTSD, IGF1, KHSRP, CYP19A1, HMGA2, EP300, KRT17, TFF1, STAT3, BRCA2, ASPM, TP63, IGF1R, GADD45A, JAK1, CDKN1B, CCNB1, MYC, VEGFA, IRF9, HIF1A3ATM, BRCA2, ESR1
BARD1YES1ESR11ESR1
TP53YES159ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING16BRCA2, ESR1, TP53, AKT1, BRCA1, CHEK2
ESR1YES68UGT2B15, AR, PELP1, EGFR, FLT1, RET, AVP, NRF1, CDK4, SERPINE1, PGR, FOS, VEGFA, CHAT, RUNX2, ZFHX3, CYP19A1, SERPINB9, TYMS, DCT, CXCL12, PTMA, HTRA2, NR5A2, CD24, HSPB1, CYP1B1, CTNNB1, MMP13, BRCA1, CYP2C19, BLM, OXT, TAC3, CCNA2, ZEB1, CDKN1A, STAT5A, TERT, MDM2, PMAIP1, CYP1A1, RARA, TP53, JUN, CDH1, AMH, CRHBP, MYC, TFF1, E2F1, CRH, KDR, BTG2, BCL2, UGT1A4, TGFA, KRT19, F12, FOXP1, ESRRA, GREB1, CTSD, JUNB, ESR1, YWHAQ, CCND1, CDKN1B4BRCA1, ESR1, TP53, CDH1
RAD51YES1HR0
DNMT1NO24MBD2, BIRC5, IL32, CDKN2A, CDKN2B, TIMP3, CASP8, PROM1, CXCR4, BAG1, TERT, GAD1, TNFRSF10B, CDH1, VEGFA, RELN, EPCAM, MGMT, IL3, KIR2DL3, RUNX3, RB1, BMP2, MSH22CASP8, CDH1
MYCNO102CBFB, PRDX3, CHKA, ATF3, CDK4, PCNA, CEBPA, LDHA, DKK1, MTDH, TFAP4, HLA-G, CDC25A, UBE2C, HLA-B, GATA1, TP53, BAG2, PMAIP1, CDK6, WRN, PGK1, TFAM, IGK, JUNB, ZFP36, HNRNPA1, MYB, SART3, EBNA1BP2, TOP1MT, ST3GAL4, CD33, CCND2, PTBP1, CDCA7, RB1, CCNA2, HLA-C, CYP3A4, FMR1, TERT, NFE2, MME, NDRG1, HDAC2, BRD7, FASLG, CCNB1, TP73, RCC1, SFRP1, HLA-F, CFLAR, BCAT1, CD38, TFRC, CCND1, MTA1, KRAS, HNRNPA2B1, CDC34, ST3GAL3, HLA-A, FUT3, NOL7, FTH1P18, VEGFA, EP300, CDK2, ASS1, SURF1, CDC25C, IER3, ST3GAL1, FOXM1, HSPA4, XPO1, CAD, SHMT1, DDX18, IGF2BP1, BMI1, IPO7, BCL2, CXCR4, SRSF1, TLX1, PRODH, NBN, CDKN1A, IFNA1, TNFRSF10B, ID2, CCNE1, SURF2, HLA-E, CREBBP, MAPK1, IL6, EIF4E, ODC13NBN, KRAS, TP53
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC14ATM, BRCA1, ESR1, NQO2
KLF4NO30ATF3, IVL, GDF15, KRT19, BIRC5, TP53, MMP2, BDKRB2, IFITM3, GPA33, CCND1, LAMA3, THBD, ALPI, IL1B, CDKN1A, VDR, CDH1, RARA, NANOG, HDC, LXN, CYP1A1, HSPA8, CDKN1C, IL6, CDKN1B, CCNB1, ODC1, CDH52TP53, CDH1
CREB1NO90NDC80, NRF1, IFNG, NR2F1, CYP19A1, CASP8, LDHA, SMAD6, SLC19A1, GSK3A, IL10, PSEN1, PPP2R2B, JUN, HPGD, IL2, GABPA, MC2R, CRTC1, AR, FLT1, SLC39A1, BDKRB2, NPY, PTGS2, MSMB, CFTR, HMOX1, MITF, AQP3, MUC5AC, STMN1, TRH, PCSK1, MMP2, CYP17A1, NOLC1, PRL, NMNAT2, TLR9, NTS, PLAT, FOS, BCL2L11, MUC4, GSK3B, CYP11B1, PPM1D, CCK, ETV3, PTGES, UXT, HLA-DOB, CGA, XPC, ACACA, SLC22A8, TH, VIP, BDKRB1, CYP11B2, POLD2, LAPTM4B, SOX9, PLAU, SNAI1, PPP2CA, SNAI2, SPRY2, HLA-DQB1, CCL5, CXCR4, ADRA1A, NR5A2, ERBB2, GRPR, BDNF, NR4A3, IL5RA, SLC20A1, RRM2B, LYL1, BCL2, CD4, NR2F6, NF1, IL6, CYP11A1, ODC1, FOXA12PPM1D, CASP8
GATA3NO33IL12RB2, KLK1, CHST4, IFNG, EPO, ERVW-1, TEK, MUC1, CD40LG, HSD17B1, TRA, ERG, ESR1, FUT7, ZEB1, CDH3, CDX2, FOXC1, FOXC2, PAEP, IL10, CDH1, MMP1, CD8A, DLC1, CXCL1, GATA3, IL4, IL5, EPOR, CD8B, STAT4, MYCN2ESR1, CDH1
CTBP1NO4BRCA2, BRCA1, CLDN7, KRT182BRCA1, BRCA2
ID4NO2BRCA1, ESR12BRCA1, ESR1
VDRNO36DKK4, CST5, PRL, LRP5, IGFBP3, BGLAP, EGFR, TPT1, IL12B, SKP2, PHB, CYP7A1, RUNX2, TNFRSF21, CYP1A1, ERBB2, CD14, CYP24A1, CYP3A4, CDKN1B, FOXP3, PODXL, IL10, HOXA10, CDH1, CALB1, SPP1, AMH, TRPV6, DDIT4, CXCL8, IL2, PTH, IL6, CAMP, TNFSF112PHB, CDH1
JUNNO155PTN, TXN, ATF3, MEF2D, SMN1, TP53, MMP2, SPRR1B, EDN1, TNFRSF1B, NQO1, ELN, CYP19A1, GJA1, MAP3K1, ACTA1, STAR, NEIL1, ALOX12, PPARA, LOR, SLC19A1, NOS2, IFNB1, IL1B, MGMT, FGF7, JUN, ETS2, GSTP1, PCK2, BECN1, ITGB8, MMP3, CREM, IL23A, HEY1, FOSL1, CCL2, TERT, NAMPT, FASLG, BCL2L1, EGFR, RUNX2, CDKN1A, EZH2, MYB, DCN, NPY, PLAT, RARG, PTGS2, MAPK8, CCND2, NGF, TFF1, TNF, LBP, NFKB2, CYP2J2, NOX5, BEX2, NOS3, RARA, MMP1, F3, ETS1, ABCB1, STMN1, PLAUR, TNFRSF10A, IBSP, DDX21, TP73, SPRR3, PPARD, UGT2B15, RARB, IFNG, IL12A, AR, OPRM1, REN, NTS, MSR1, SYK, FOS, APP, CDK5R1, ITGAX, CCND1, CCK, PDK1, CYP1A2, BRCA1, CTSL, MMP20, MAT2A, PDHA1, SPP1, TIMP2, OXTR, VEGFA, SOX7, RHOB, CA2, IL24, CXCL8, IL2, EZR, IL1A, APOC3, MMP9, FGL2, NEFL, SOD2, BATF3, POLD2, FIGF, PLAU, DDIT3, PENK, PGR, IL12B, LGALS3, RELB, LDHA, CCL5, FAS, SMAD7, GCLC, MMP7, CD82, CYP11A1, MGP, ATG5, CSF2, SPI1, VDR, MFI2, MMP12, CTGF, IL5RA, VCAM1, CSF1, TNC, APOM, IL3, CD69, IL6, MMP13, CSTA, KRT16, MYC2BRCA1, TP53
SIRT1NO43ACAN, TBX3, ESRRG, EZH2, CFLAR, NR1I2, FOXO3, SELE, HSF1, ABCB1, TP73, CCND1, NR5A2, CFH, HYOU1, IL1B, SHC1, COL1A2, NBN, CDKN1A, CTNNB1, MCL1, TNFRSF10B, BCL11A, CDH1, PARP1, ICAM1, PAX6, DLL4, SIRT6, NOTCH1, WRN, ADAMTS5, NDRG1, PER1, TNF, MMP9, COL10A1, TP53, EGLN1, MYC, PPARG, HIF1A3NBN, TP53, CDH1
PARP1NO25FN1, SNAI1, IFNAR1, IFNG, VIM, SERPINE1, TERF2, TCF4, THBD, FOXO1, E2F1, CDKN1A, SMARCB1, CDH1, SH3BP2, FBN1, IL10, RELA, NFKB1, CXCL1, BRCA2, BCL2, HTR1A, JUN, SERPINF12BRCA2, CDH1
CREBBPNO27ALOX15, CLOCK, CSF2, TP53, CREB1, EGFR, PTGS2, IL4, LDHA, INSM1, HOXA9, CCK, ONECUT1, BRCA1, PPARA, RS1, CDKN1A, RARA, TRIM22, NPAS2, EP300, PCK2, HOXA10, IRF1, PSMC5, HINFP, RAD513BRCA1, RAD51, TP53
HDAC1NO64NFYA, PSIP1, RECK, EIF2AK1, RARB, BIRC3, IGFBP3, CD1D, HSPA5, FOS, CDKN2A, TXNIP, PTGS2, RUNX3, NOS3, RHOB, MICA, EGR1, FAS, KLF4, CLDN7, HMGCS1, CD44, CCND2, MICB, CD82, RECQL4, GRIN2B, SP1, SERPINB5, PHB, BIRC5, COMP, CDC25A, ESR1, FSHR, HOXA9, AR, GAD1, RELN, KLK3, CDH1, SPP1, TP53, PCNA, CXCL8, ICAM1, MGMT, TFF1, EPCAM, STAT3, BRCA2, ABCB1, BCL2A1, SNAI2, HLA-DRA, CDKN1A, MMP28, MMP9, TJP1, TERT, IL2, CCND1, CDKN1B5PHB, ESR1, BRCA2, TP53, CDH1
HDAC2NO22TWIST1, SNAI2, CAD, CCL2, CD1D, SP1, CCNE1, MUC5AC, KLF4, BMP7, PHB, CDKN1A, PRDX2, IGF1, TNFSF10, CDH1, CXCL8, ALOX5, APAF1, GRM2, MYC, MYCN2PHB, CDH1
YY1NO74FCER1A, CFTR, EGFR, GDAP1, POSTN, TP53, ATP2C1, IFNG, ADORA2A, KIR3DL1, TOP3A, HBE1, LDLR, SERPINE1, LRIG2, HSPA5, GBP1, HLA-DRA, APC, HAS2, CCL13, SNRPN, FMO3, TFRC, CTCF, FAS, TF, CXCR4, FCGR3B, DNAJB4, HSD3B2, ERBB2, SURF1, TDO2, IVL, BRCA1, DEK, COX7C, CETP, ERCC5, NOS2, BDKRB1, SLC26A3, EPAS1, ACTC1, ZNF175, BAP1, TNFRSF10B, HOXB7, NF1, OPRM1, PCNA, PARP1, PRDM2, VWF, TP73, CCR5, CBX5, SURF2, IL4, NR3C1, PDIA6, CYP3A5, CREBBP, HCFC1, IL5, DBH, RB1, FDPS, FCGR2B, LSS, MYC, HOXB13, COL1A22BRCA1, TP53
HDAC9NO22MYEF2, SOX9, PRL, TP53, DIRAS3, CFLAR, CDKN2A, STAT6, HSPA5, APP, CITED2, IGFBP1, CDKN1A, CLGN, TNFRSF10B, RELA, HPGD, NFKB1, MEF2A, IL18, MMP13, ESR12ESR1, TP53
STAT3NO129IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP124PHB, TP53, AKT1, CDH1
USF2NO42PF4, FCER1A, CTSB, IGF2R, NR5A1, CEACAM1, MYH9, TRAP, ASPH, CEACAM5, TOP3A, PTGS2, PDX1, CYP19A1, HOXB4, THBS1, CFTR, TCN2, TGFB1, PKLR, FMR1, SLC19A1, APC, CD2, TGFB2, PIGR, CTSD, ASCL2, PTPN6, CXCR4, BRCA1, FBP1, BRCA2, CXCR2, ATP5A1, APOA2, APOA5, B2M, HMOX1, TERT, ABCA1, LIPC2BRCA1, BRCA2
IFI16NO6WT1, AR, TP53, MYC, ICAM1, BRCA12BRCA1, TP53
NFKB1NO306NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC64TP53, BRCA2, AKT1, CDH1
RBL2NO3BRCA1, RAD51, E2F42BRCA1, RAD51
HMGA1NO17PTGS2, SP1, CXCL1, XPA, POU1F1, INSR, CRYAB, CDC25A, TWIST1, IL1B, CDH1, CD44, TP53, RAG2, SLC2A3, BRCA1, KL3BRCA1, TP53, CDH1
EP300NO56ALOX15, PCNA, MDM2, VCAM1, EIF2AK1, PTGS2, BIRC5, IFNG, EPO, PARP1, TBXAS1, BGLAP, CDKN2B, IL12B, RS1, LDHA, CCNE1, ABCB1, TP73, KLF5, LAMA3, HINFP, THBD, ERBB2, DNMT1, BRCA1, WT1, CCNB2, CDKN1A, ZEB1, GFAP, TRIM22, SPP1, CYBB, RELA, NPAS2, CXCL8, VEGFA, NFKB1, CRABP1, CA9, NR0B2, NR1H4, CREBBP, CLOCK, IGFBP3, IL5, IL6, SLC9A2, MMP9, IGF1, KRT16, MYC, CCND1, PML, RAD512BRCA1, RAD51
RELANO302NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC64TP53, BRCA2, AKT1, CDH1
EZH2NO31PCNA, SFRP1, ADRB2, TWIST1, SNAI2, CDKN2B, CDKN2A, APC, RUNX3, PIP5K1C, CCNE1, DACT3, HOXB13, ALDH1A1, BRCA1, FOXC1, CDKN1A, VDR, HDAC1, RPLP0, CDH1, SATB1, TP53, AXL, ADAMTS1, SSTR1, FBXO32, MMP2, PEBP1, CIITA, CCND13BRCA1, TP53, CDH1
TWIST1NO35ATM, AKR1C2, CDH2, GDF15, MAPK1, FN1, RBL2, NR2F1, MYB, MMP2, RAP1A, BMI1, FOS, FGF2, RUNX2, ITGB1, CD44, ERBB3, PFDN4, DKK1, AKT2, ESR1, F2R, CDH1, NF1, TIMP1, ICAM1, BCL2, ILK, MAPK3, MMP1, YBX1, CTPS1, SRPX, DNM33ATM, ESR1, CDH1
TWIST2NO25ATM, AKR1C2, GDF15, POSTN, FN1, RBL2, NR2F1, MYB, RAP1A, FOS, RUNX2, ITGB1, CD44, ERBB3, DKK1, F2R, CDH1, NF1, CDH2, ICAM1, ILK, PFDN4, MMP2, CTPS1, SRPX2ATM, CDH1
RB1NO29CDK1, DDIT3, BIRC5, MAP3K5, EBNA1BP2, DNMT3A, FOS, SFTPD, SP1, DHFR, HBP1, BRCA1, CDKN1A, RBL1, TFDP1, CDH1, ATF2, PCNA, E2F2, ELF1, E2F1, WRN, FGFR1, TP53BP2, RB1, IGF1, MYC, PPARG, E2F32BRCA1, CDH1
ETS1NO90PF4, ITGB3, TP53, TBXAS1, GABRE, PTHLH, TNFSF14, CD14, IGFBP1, BAX, SLC26A3, IL2, MGAT5, VWF, HPGD, CA9, MMP3, MMP9, CSF3R, IL2RB, TERT, THY1, FLT1, FGFBP1, CSF2, MYB, FLI1, ANGPT2, GP6, EGR1, TMEM158, CSNK2B, ERG, SQSTM1, WAS, F13A1, CD8A, MMP1, TGFBR2, ABCB1, ATXN2, NDRG1, SPRY2, HSPB8, BMP4, PRL, TBXA2R, CDKN2A, CHUK, NKX3-1, TAF12, MUC4, HSPE1, TRB, AXIN1, BRCA1, LCK, MMP10, SPP1, RHOC, ICAM1, ANPEP, CSNK2A1, IL5, CR1, HSPA6, HMOX1, CASP1, MDM2, PLAU, SNAI1, TFAP2A, CTSB, TRA, CXCR4, ECE1, SRD5A1, HSPA1L, DUSP6, CDKN1A, FOXD1, GRPR, CTGF, PARP1, TNC, HSPA8, IL3, COL1A1, MMP13, CD62BRCA1, TP53
MTA1NO20EPHA2, NOS2, MMP9, EGFR, MNAT1, MTA3, SNAI1, SMAD7, BCL2L1, CDH1, MYC, CDKN1A, SNAI2, PTEN, ITGB3BP, ESR1, CDKN2A, SUMO2, BRCA1, TFF13BRCA1, ESR1, CDH1
NR3C1NO36CALD1, PNRC1, TP53, RPS6KA3, BAX, SRF, SLC10A2, SCNN1A, BGLAP, TAT, RLN2, S100P, CYP19A1, MUC4, CCND1, NR1I2, ETS1, PPIG, BRCA1, ELK1, CSF1R, CDKN1A, UGT1A1, RLN1, SPP1, BAD, NFKB1, STAT1, COX1, NR3C1, CDK4, CDK6, CCND3, ATP1B1, ATF2, MAOA2BRCA1, TP53
ARNO83UGT2B15, PTPN1, CDH11, AKR1C3, USP26, FOLH1, CCR2, CDK20, CDK6, PNRC1, ARG1, XIAP, VIM, ARG2, EGFR, CFLAR, ETV1, BSG, IGF1R, MUC1, WEE1, PTGS2, NKX3-1, AKT1, NRAS, CDH1, EP300, KLF5, ACTA1, CLK3, FN1, TNF, PRL, ERBB2, ERBB3, CRISP3, CTNNB1, PTEN, CRISP1, SERPINB5, TSC2, NAT1, CDKN1A, GREB1, SEPT7, IFI16, PIGR, KLK3, PC, STIM1, SRD5A3, TCF7L2, JUN, TMPRSS2, RELA, TJP1, BTG1, VEGFA, NFKB1, HMMR, FKBP5, KLK4, CRH, CDH2, BTG2, TGFA, SESN1, CDC6, TH, ALDH1A3, KISS1, KISS1R, PEBP1, KLK2, ATAD2, HMOX1, TSC1, WNT7B, PEG10, TRPS1, CCND1, PIP, FOXA13CDH1, AKT1, HMMR
E2F4NO20AURKB, MYC, TOPBP1, KIAA0101, CDK2, TTK, FGF2, LIN54, BIRC5, HCFC1, MAP3K5, MCM10, PLK1, CCNB1, PEG10, DIRAS3, BRCA1, CCND1, RAD51, E2F22BRCA1, RAD51
E2F1NO123WWOX, DOK1, MEFV, MYBL2, MCM8, FZD1, DIRAS3, PIN1, PCNA, DHFR, ETV4, LRBA, RPA2, FSHR, SERPINB5, PCSK6, TP53, FOXM1, E2F1, IL23A, CD2AP, HMGA1, XRCC1, FHIT, IRF3, ATM, MYC, MT1G, NRIP1, FLT1, RRP1B, MYB, SERPINE1, BMI1, CDKN2A, SKP2, MAPK8, CCNE1, CASP7, CDCA7, HIC1, THBS1, RB1, TNF, IL1B, ULK1, ERCC1, CUX1, TERT, MCL1, AR, KIR3DL1, NPAT, PDK4, DDB2, E2F6, ABCB1, BBC3, AURKA, NOX4, MYCN, CCNB1, TP73, FGFR1, RRM1, RRM2, HSPA5, TLR3, MUC4, CCND1, MCPH1, BRCA1, DRAM1, ERCC5, BIRC5, TYMS, RASGEF1B, MAP1LC3A, VEGFA, RACGAP1, FANCA, UHRF1, CHEK1, MCM5, RASGRP1, APAF1, ISYNA1, ECT2, TNFSF11, AURKB, CDK1, MDM2, DDIT3, MAP3K5, DBF4, PNRC2, KIF2C, POLA1, CTNNBIP1, ELF4, KDR, TP53INP1, ATAD2, CCL3, TK1, ATG5, CDKN1A, SIVA1, PEG10, TOP2A, CDAN1, CHEK2, DUSP1, ASF1B, DAPK2, PTPRO, BCL2, CREBBP, TP53BP2, GINS3, MYH10, PPARG, PPP1R13B4ATM, BRCA1, CHEK2, TP53
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
TSG101YES2MAZ, TTF20
HMMRYES1AR0
ATMYES6SP1, TWIST2, BTF3, TWIST1, BRCA1, E2F11BRCA1
NQO2YES2SP1, JUND0
AKT1YES7APC, STAT3, GLI1, AR, TP53, RELA, NFKB11TP53
PPM1DYES1CREB10
NBNYES2MYC, SIRT10
CDH1YES49AR, MTA2, FOXM1, ZEB2, SNAI1, TWIST2, TWIST1, EZH2, RBBP7, FOXA2, TCF3, LMO2, SPDEF, YBX1, KLF4, MTA1, LCOR, HDAC3, DNMT1, FOXQ1, HOXA7, TCF12, ESR1, SIRT1, WT1, ZEB1, FOSB, SMARCA4, VDR, HDAC1, TFAP2A, RELA, PARP1, HMGA2, NFKB1, KLF8, HDGF, STAT3, GATA3, HDAC2, SNAI2, CBX7, SALL4, RB1, HMGA1, KLF6, ZNF217, SIX1, HIF1A1ESR1
CHEK2YES2E2F1, TP531TP53
BRCA1YES33WWP1, RBL2, EZH2, DLX4, CTBP1, SP1, E2F4, ID4, NCOA3, USF2, MTA1, E2F1, FOSL2, RBL1, FOXP3, IFI16, NFE2L2, SP100, TP53, CTCF, EP300, ETS1, E2F6, NR3C1, YY1, JUN, TP53BP1, RB1, HMGA1, ESR1, AHR, CREBBP, FOXA12ESR1, TP53
BRCA2YES11ESR2, CTBP1, HDAC1, ELF1, TP53, USF2, RELA, PARP1, BRCA1, NFKB1, USF12BRCA1, TP53
BARD1YES1BRIP11BRIP1
KRASYES1MYC0
TP53YES50ATM, RELA, ERCC2, ETS2, ELF4, EZH2, HDAC9, FOS, PAX5, MCM4, RUVBL1, ZBTB2, EGR1, KLF4, MCM2, AATF, PAX2, TFDP1, STAT1, IRF1, PAX8, HIPK2, HDAC1, SIRT1, MDM4, VHL, ESR1, ING1, IFI16, STAT3, JUN, TP53, ABL1, NUPR1, NFKB1, E2F1, ETS1, CREBBP, HOXA10, NR3C1, YY1, NF1, ING4, HMGA1, SOX6, BDP1, MYC, PPARG, PML, MYCN3ATM, ESR1, TP53
ESR1YES27MECP2, RUNX2, TWIST1, TFAP2C, PGR, HDAC9, NCOR1, SP1, NKX3-1, ARNT, ID4, HDAC7, MTA1, BRCA1, BARX2, XBP1, STAT5A, LEF1, KDM4B, HDAC1, BARD1, STAT5B, PIAS3, TP53, GATA3, NR2E3, ESR14BRCA1, BARD1, TP53, ESR1
PHBYES4VDR, HDAC1, HDAC2, STAT30
CASP8YES4RUNX3, MEN1, DNMT1, CREB10
RAD51YES4CREBBP, EP300, RBL2, E2F40
PIK3CAYES1FOXO30
PMAIP1NO7ATM, ESR1, KLF9, TP53, KLF6, TP73, MYC3ATM, ESR1, TP53
GADD45ANO7ATM, NFYA, POU2F1, TP53, BRCA1, JUND, POU5F13ATM, BRCA1, TP53
IGF1RNO8WT1, ATM, VHL, TBP, AR, TP53, BRCA1, NKX3-13ATM, BRCA1, TP53
XPCNO6SP1, TP63, CREB1, TP53, BRCA1, HIF1A2BRCA1, TP53
CTSDNO9ARNT, ESR2, TP53, USF2, USF1, ESR1, NFATC3, BRCA1, MYCN3BRCA1, ESR1, TP53
MDM2NO23TFAP4, TP53, NFATC2, JUND, DNMT3A, SP1, ELF4, ZBTB2, SKI, MLLT10, E2F1, FOSL2, ELL, MLLT3, ETS2, EP300, ETS1, FUS, TSG101, ESR1, NR4A1, TP73, MYCN3ESR1, TP53, TSG101
TERTNO30CTCF, MZF1, ETS2, MXD1, USF2, SP1, ID2, TAL1, SMAD3, DNMT1, E2F1, WT1, ESR2, HDAC1, JUN, TP53, RELA, NFKB1, TP73, ETS1, HIF1A, STAT3, MEN1, NFATC2, FLI1, USF1, ESR1, MYC, PITX1, MYCN2ESR1, TP53
HIPK2NO3ATM, PML, TP532ATM, TP53
CCND1NO62POU4F2, RELA, E2F4, MYBL2, AR, MECP2, PML, BHLHE41, EZH2, ATF2, PGR, JUND, FOS, PAX5, STAT5B, RUNX3, RNF14, POU2F1, EGR1, EP300, KLF4, HOXA1, STAT5A, CTNNB1, BRCA1, ESR1, SIRT1, VHL, SP1, KLF6, LEF1, HDAC1, KDM4B, NKX3-1, SOX2, HOXB7, JUN, ZNF24, TP53, NANOG, E2F8, NELFCD, NFKB1, E2F1, FHL2, STAT3, TCF4, BTG2, NR3C1, SP4, TSC22D3, SNIP1, HEXIM1, ING4, LIN28A, HIF1A, SMARCA4, SP3, MYC, PPARG, KLF5, SOX63BRCA1, ESR1, TP53
SLC2A1NO4ATM, HDAC5, HIF1A, TP532ATM, TP53
CDKN1BNO27KAT2B, NFYA, TP53, SP1, KLF4, HDAC3, COPS5, FOXO1, BRCA1, VHL, CUX1, ZNF300, VDR, HDAC1, STAT3, NFYC, HOXB7, NR4A1, UTF1, ING4, FHL2, NFYB, PROX1, MEN1, ESR1, IRF9, MYCN3BRCA1, ESR1, TP53
CDKN1ANO118ABL1, TFAP4, TP53, MYF5, TCF3, HDAC9, PAX5, ZBTB2, LCOR, E2F3, ZBTB5, HSF1, ELL, TSC22D3, NCOA1, TAF1, RELA, MYOD1, STAT1, PTTG1, KLF16, ESR1, JUNB, MYCN, KAT2B, AR, BCL6, KLF10, EZH2, ARID1A, JUND, SP1, CEBPB, ZFHX3, ZNF300, EGR1, KLF4, AATF, HDAC7, HBP1, SMARCA4, ESR2, FOXP3, RARA, NELFCD, ING4, HDAC4, TBX2, IRF1, HDAC2, ETV6, SIRT2, MYOG, KLF6, TP73, SOX6, ATM, ERCC2, SMAD4, ETS2, NUPR1, PTMA, MLLT10, SMAD3, ETS1, CBX8, BRCA1, HIPK2, SIRT1, WT1, ZNF76, HDAC1, SMAD2, MLLT3, TFAP2A, EP300, FHL2, TP63, IRF9, EHMT2, TFAP2C, NFIX, RUNX3, RB1, HNF4A, NFIB, TAF5, SOX9, TBP, EAPP, ZBTB17, TAF4, REL, RELB, PML, SMAD7, NPM1, POU5F1, E2F1, TBX3, FOXG1, MYF6, NFIA, ATF2, PARP1, NFKB1, STAT3, GFI1, NR3C1, CREBBP, MTA1, JUN, KLF2, CDX2, SP3, MYC, PPARG, ING14ATM, BRCA1, ESR1, TP53
EGR1NO17SP1, ETS2, RELA, ATF5, MAML1, HDAC1, NFKB1, TP53, NAB2, NKX2-3, RBMX, FOXO1, BRCA1, ETS1, STAT6, KLF5, STAT12BRCA1, TP53
CTNNB1NO8AR, NKX2-5, LEF1, TP53, NELFCD, SOX6, ESR1, SIRT12ESR1, TP53
FOSNO31HMGN1, MITF, NCOA6, TBP, SRF, RBMX, FOS, ZBTB7A, SP1, NKX3-1, ARNT, STAT6, CREB1, BRCA1, HOPX, ELK1, TWIST2, ESR1, ESR2, ELK4, HDAC1, NF1, TWIST1, HSF2, GTF2I, STAT3, CREM, JUN, RB1, SMARCA4, AHR2BRCA1, ESR1
VEGFANO53ATM, WT1, AR, FOXM1, ID3, ATF4, COPS5, TFAP2A, EPAS1, PGR, RUNX1, SP1, NKX3-1, TEAD4, ARNT, EGR1, EP300, KLF5, MYC, SMAD3, HDGF, HTATIP2, DNMT1, FOXO3, HIPK2, ZFP36, HEXIM1, VHL, ZFP36L1, XBP1, ESR2, NR1H4, HOXB7, JUN, ZNF24, TP53, RELA, HDAC4, RUNX2, NFKB1, BRCA1, FOXQ1, E2F1, STAT3, UHRF1, TCF4, PTTG1, ZNRD1, HIF1A, ESR1, SP3, MEF2C, E2F34ATM, BRCA1, ESR1, TP53
BTG2NO7AR, RELA, FOXM1, TP53, ESR1, NFKB1, PHB22ESR1, TP53
CYP19A1NO23NR5A1, NR0B1, FOXL2, NR2F1, CREB1, PGR, RARG, SP1, USF2, NR5A2, BRCA1, ESRRA, WT1, JUN, RELA, NFKB1, STAT3, NR3C1, NR2F6, CEBPB, CEBPD, ESR1, USF12BRCA1, ESR1
TNFRSF10BNO16SP1, ATM, STAT3, ELK1, GLI1, YY1, DDIT3, TP53, MYC, DNMT1, GLI2, RELA, HDAC9, NFKB1, ATF4, SIRT12ATM, TP53
FOXM1NO7SP1, ATM, FLI1, MYC, TP53, E2F1, FOXO32ATM, TP53
FLT1NO8EGR1, ATF1, CREB1, TP53, ESR1, EPAS1, E2F1, ETS12ESR1, TP53
STAT3NO9SOX3, FOXO1, HDAC1, TP53, TCF7L2, PIAS3, ZNF382, BRCA1, STAT12BRCA1, TP53
HRNO2RAD51, TP532RAD51, TP53
DDB2NO7SP1, TP63, TP53, NF1, BRCA1, E2F1, E2F32BRCA1, TP53
DUSP1NO7ATM, CREM, TP53, ATF2, PGR, E2F1, STAT62ATM, TP53
MYCNO66E2F4, LEF1, PGR, FOXM1, TBP, FUBP1, TP53, MYBL2, SMAD4, MXI1, MYB, AATF, ZNF382, FOS, ZBTB7A, SP1, E2F5, RBL1, TCF4, TBL1X, EP300, SMAD7, HDAC3, TCF3, SRSF1, SMAD3, CNBP, TLX1, ESR1, SIRT1, WT1, APC, CTNNB1, CEBPE, PRDM1, IFI16, DLX5, HDAC10, ZNF300, JUN, ETS2, RELA, BCL6, NFKB1, BRCA1, E2F1, STAT3, HDAC11, CEBPA, HOXA1, PTTG1, PPARG, YY1, MTA1, HDAC2, NF1, SNIP1, RUNX3, RB1, CTCF, ENO1, BDP1, AHR, STAT4, RFX1, HNF4A3BRCA1, ESR1, TP53
CYP1A1NO12RELA, ARNT, VDR, NFKB1, KLF4, NFIC, RARA, ESR1, BRCA1, PPARA, AHR, USF12BRCA1, ESR1
CDK4NO12SP1, STAT3, SOX9, NR3C1, IRF1, RELA, TP53, SATB1, ESR1, MYC, NFKB1, SOX62ESR1, TP53
EGFRNO30AR, BCL3, WWP1, NR3C2, TFAP2A, PGR, NFKB2, SP1, EGR1, PML, HDAC3, MTA1, BRCA1, WT1, VDR, HOXB7, JUN, TP53, RELA, LRRFIP1, NFKB1, STAT1, STAT3, YY1, YBX1, ESR1, JUNB, PPARG, CREBBP, TSG1014BRCA1, ESR1, TP53, TSG101
TFF1NO17HMGN1, NFATC3, ESR2, AIP, HDAC1, RELA, MTA1, MECP2, NELFB, JUN, FOXA2, ESR1, SP3, BRCA1, NFKB1, NCOA4, FOXA12BRCA1, ESR1
BAXNO25ATM, ING4, ERCC2, TP53, MYCN, PAX5, SP1, GFI1, PML, ABL1, AATF, MLLT10, ETS1, WWTR1, ELL, MLLT3, PER1, RELA, NFKB1, STAT1, TP63, NR3C1, ING1, TP73, HIF1A2ATM, TP53
MCL1NO12ATM, STAT3, ELK1, RELA, ATF4, DDIT3, TP53, SRF, ELK4, E2F1, NFKB1, SIRT12ATM, TP53
CCNA2NO14SP1, CREM, RBL1, TP53, E4F1, SOX6, NFATC2, NR4A1, E2F3, ESR1, MYC, BCL6, ZBTB16, ZHX22ESR1, TP53
FASNO25ATM, NFYA, TP53, ATF2, PURA, FOS, SP1, EGR1, GLI2, STAT1, GLI1, YBX1, HDAC1, NFYB, NFYC, JUN, TFAP2A, RELA, NFKB1, HDGF, STAT3, SREBF1, SREBF2, NFKBIA, YY12ATM, TP53
RB1NO19KAT2B, MYC, UHRF1, BDP1, RB1CC1, YY1, MYF6, RB1, HCFC1, MYOG, ID2, DNMT1, TP53, CTNNB1, MYOD1, DNMT3A, MYF5, E2F1, PAX52RB1CC1, TP53
CCNB1NO15MYC, FOXM1, E2F4, PTTG1, IRF1, KLF5, TP53, TFAP2A, RELA, KLF4, YBX1, BRCA1, NFKB1, E2F1, USF12BRCA1, TP53
E2F1NO27KAT2B, EIF2AK2, E2F7, POLR1A, PGR, SP1, NFKB1, YBX1, PAX8, NR2F2, E2F8, SIN3A, TRIM16, NR4A1, TP53, RELA, PARP1, PA2G4, E2F1, E2F6, NR0B2, IRF1, HES1, HCFC1, RB1, ESR1, TP732ESR1, TP53
TYMSNO8SP1, TFDP1, TP53, TFCP2, YBX1, ESR1, E2F1, USF12ESR1, TP53
BCL2NO43ATM, ING4, ERCC2, TBP, TP53, TWIST1, CREB1, MYB, SIM2, PGR, PAX5, SP1, CEBPA, ATF5, MSX2, NCOA3, GLI2, NR1I2, HOXA1, GLI1, TFAP2A, E2F1, DEK, WT1, ATF1, ING2, SATB1, PER1, ABL1, PARP1, NFKB1, MYC, DDB2, STAT3, BACH2, ZBTB16, RELA, ZNRD1, ESR1, PAWR, PPARG, IRF1, FOXA13ATM, ESR1, TP53
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
TSG101HMMRNo1THRSP
TSG101ATMNo8DAXX, BCAS3, MDM2, BAG6, TP53, MTA3, HNRNPUL1, TFF1
TSG101NQO2No2NXF1, MOV10
TSG101AKT1No15NF2, IQGAP1, MDM2, VCP, DNAJB1, CDKN1A, FASN, RASL10B, NEDD4, AR, YBX1, THRSP, EP300, MTA3, TFF1
TSG101XRCC3No7SCGB3A1, BCAS3, XPO1, SCAMP3, TNKS1BP1, TRIM25, TFF1
TSG101RB1CC1No4UBC, THRSP, RNF111, TP53
TSG101PPM1DNo2UBC, MDM2
TSG101RAD54LNo1BAG6
TSG101FAM175ANo1UBC
TSG101NBNNo3EP300, RAD18, MDM2
TSG101CDH1No5NDRG1, ACTN4, IQGAP1, EP300, MDM2
TSG101CHEK2No5TP53, DAPK3, MDM2, AATF, VCP
TSG101BRCA1No13AR, VCP, PABPC1, RAD18, DNAJB1, TP53, TRIM74, JUN, TRIM46, UBC, YBX1, UBE2I, EP300
TSG101BRCA2No3VPS28, NEDD4, TP53
TSG101BARD1No10LARP1, SMCHD1, WDR5, WDR26, TP53, EWSR1, YBX1, FAM9B, HNRNPUL1, MOV10
TSG101KRASNo2THRSP, BCAS3
TSG101TP53Yes25VASP, PABPC1, DAXX, DAPK3, EWSR1, BCR, IQGAP1, VCP, THRB, DNAJB1, CEP55, CDKN1A, MDM2, TP53, EP300, MOV10, CHMP4B, NR3C1, WDR5, STK11, YBX1, UBC, UBE2I, PDLIM7, TSG101
TSG101ESR1No21ARFGAP2, CDKN1A, BCAS3, VCP, PABPC1, KLK5, EP300, CAPRIN1, WDR5, UPF1, SFPQ, TP53, JUN, MDM2, XPO1, NONO, EWSR1, YBX1, UBE2I, ACTN4, TRIM25
TSG101PHBNo9NF2, AR, BCAS3, VCP, ADRB2, TP53, UBC, XPO1, NTRK1
TSG101PALB2No4THRSP, BCAS3, MOV10, KLK6
TSG101CASP8No6KLK5, BIRC2, YBX1, PRSS50, TP53, UBC
TSG101RAD51No5UBE2I, TFF1, RAD18, NXF1, TP53
TSG101PIK3CANo4NTRK1, THRSP, WDR5, GRB2
HMMRATMNo3BRCA1, IL24, NAT2
HMMRAKT1No8IL24, CALM1, LRRK2, TBK1, DCTN1, ACTB, BRCA1, THRSP
HMMRBRIP1No1BRCA1
HMMRXRCC3No2ITIH5, GREB1
HMMRRB1CC1No5THRSP, ITIH5, TBK1, IL24, GREB1
HMMRPPM1DNo2ITIH5, NAT2
HMMRFAM175ANo1BRCA1
HMMRNBNNo3BRCA1, BACH1, NAT2
HMMRCHEK2No5BRCA1, IL24, MAPK1, ITIH5, CDH13
HMMRBRCA1Yes6BACH1, MAPK1, ITIH5, AURKA, TPX2, BRCA1
HMMRBRCA2No2BRCA1, BACH1
HMMRBARD1No4AURKA, BRCA1, MAPK1, BACH1
HMMRKRASNo4CALM1, IL24, MAPK1, THRSP
HMMRTP53No11SPICE1, CSNK1E, BACH1, AURKA, NIN, MAPK1, TUBB2A, CSNK1A1, ACTB, BRCA1, STX5
HMMRESR1No6CALM1, TBK1, MAPK1, SVIL, ACTB, BRCA1
HMMRPHBNo2ACTB, TMEM63B
HMMRPALB2No6IL24, GREB1, BACH1, NAT2, THRSP, BRCA1
HMMRCASP8No5IL24, LRRK2, MAPK1, GREB1, CDH13
HMMRRAD51No5ITIH5, BRCA1, IL24, CDH13, NAT2
HMMRPIK3CANo2IL24, THRSP
ATMAKT1No25MDM2, MAPK14, IKBKG, MTA3, SKP2, FOXO3, SMAD7, CREB1, WHSC1L1, PPP1CC, TOPBP1, SMARCB1, PRKDC, TRAF6, OSGIN1, NR4A1, TCL1A, BRCA1, TFF1, IL24, HSPA8, PPP1CA, PPP2R4, EIF4EBP1, BCL10
ATMBRIP1No5BRCA1, TOPBP1, BLM, RPA1, MLH1
ATMXRCC3No7BRCA2, CDK9, OSGIN1, TFF1, BCAS3, RNF20, RAD51
ATMRB1CC1No11VHL, IL24, RNF20, ERRFI1, HUWE1, RPA1, TP53, RPA2, DYRK2, SMARCB1, WHSC1L1
ATMPPM1DNo6MDM2, ERRFI1, OSGIN1, NAT2, H2AFX, WHSC1L1
ATMRAD54LNo1BAG6
ATMFAM175ANo3PARP1, BRCA1, MDC1
ATMNBNYes33ATM, ATRIP, MDM2, FANCD2, KAT5, MDC1, RAD50, RFC1, BMI1, MSH6, SKP2, DCLRE1C, ATR, MSH2, RPA1, MCPH1, RBBP8, RPA2, SNW1, BRCA1, DDX1, TOPBP1, TERF1, MRE11A, PRKDC, TERF2, ATF2, NAT2, H2AFX, WRN, BLM, MLH1, XRCC5
ATMCDH1No10HSPA8, XRCC5, MDM2, HDAC1, SMAD7, PPP1CA, SKP2, E2F1, RAD17, GMNN
ATMCHEK2Yes20ATM, VHL, ATR, BRCA2, MDM2, MSH2, PRKDC, IL24, ELAVL1, TP53BP1, TP53, MDC1, RAD50, TRIM28, PER3, NR4A1, BRCA1, RNF20, CHEK2, WHSC1L1
ATMBRCA1Yes49ATM, ATRIP, RELA, CHEK1, FANCD2, SMARCB1, TOPBP1, SMC3, CSNK1D, RAD51, RFC1, PEX5, KAT5, H2AFX, SKP2, DCLRE1C, ATR, MLH1, BRAT1, POLR2A, RPA1, CDK9, RBBP8, FOXO3, MRE11A, NBN, SMC1A, TERF1, HDAC1, PRKDC, TERF2, TP53, MDC1, ABL1, PARP1, HSPA8, MSH6, BRCA1, E2F1, BRCA2, HUWE1, TP53BP1, PPP1CA, BLM, HIF1A, RAD50, CHEK2, MSH2, XRCC5
ATMBRCA2Yes11ATM, ATR, TP53, SMC3, MCPH1, RPA1, CHEK2, BRCA1, H2AFX, RAD51, FANCD2
ATMBARD1No26MDC1, TOPBP1, HNRNPUL1, RAD50, KAT5, MSH6, SKP2, MSH2, CDK9, RBBP8, BRCA1, TOP1, NBN, SMC1A, MRE11A, ELAVL1, TP53, RELA, PARP1, H2AFX, BRCA2, AP1B1, POLR2A, RAD51, MLH1, XRCC5
ATMKRASNo5TRAF6, OSGIN1, BCAS3, IL24, ELAVL1
ATMTP53Yes58ATM, WWOX, RELA, MDM2, H2AFX, CHEK1, TP53, KAT5, DAXX, MDC1, RFC1, CSNK1D, CREB1, RPA1, BMI1, RNF20, MSH6, ATR, FOXO3, MSH2, BRCA1, SMAD7, SIRT7, SOCS1, E4F1, RPA2, SNW1, MAPK14, VPRBP, SMARCB1, TOP1, VHL, SPSB1, PPP1CA, HDAC1, PRKDC, CDKN2C, ELAVL1, MED1, NR4A1, TRIM28, ABL1, PARP1, HSPA8, XPC, BANP, CHEK2, PPP1CC, BRCA2, WRN, HUWE1, TP53BP1, KAT8, BLM, RAD51, RRM2B, HIF1A, TAF1
ATMESR1No32MDM2, TOPBP1, SMC3, RAD50, PPP1CA, KAT5, SKP2, MSH2, RAD51, BRCA1, DDX1, HDAC1, TOP1, SMC1A, BCAS3, CHD4, PRKDC, TRAF6, MED1, TP53, RELA, PARP1, H2AFX, PPP1CC, WHSC1L1, E2F1, HSPA8, RNF40, SPOP, POLR2A, HIF1A, XRCC5
ATMPHBNo8BCAS3, HDAC1, HUWE1, TP53, ATF2, PARP1, E2F1, SKP2
ATMPALB2No9IL24, BRCA2, ERRFI1, ALB, RBBP8, NAT2, BCAS3, BRCA1, RAD51
ATMCASP8No8IL24, ERRFI1, TRAF6, BLM, TP53, PARP1, GMNN, WHSC1L1
ATMRAD51Yes20ATM, IL24, BRCA2, ABL1, WRN, H2AFX, MSH2, RPA1, CHEK1, BLM, TP53, MDC1, MCPH1, WHSC1L1, TFF1, NAT2, MSH6, BRCA1, RAD51, FANCD2
ATMPIK3CANo3HDAC1, ATR, IL24
NQO2BARD1No1MOV10
NQO2TP53No2COPS5, MOV10
NQO2ESR1No1COPS5
NQO2PALB2No1MOV10
NQO2RAD51No1NXF1
AKT1BRIP1No2BRCA1, TOPBP1
AKT1XRCC3No11FKBP5, IMPDH2, SNAI1, MRC2, SERPINB5, OSGIN1, PHB2, HSP90AB1, NCOA4, APP, TFF1
AKT1RB1CC1No12IL13RA2, IL24, PINK1, SMARCB1, MAP3K5, SKI, EPSTI1, WHSC1L1, CTNNB1, THRSP, TBK1, MRC2
AKT1PPM1DNo5MRC2, EPSTI1, OSGIN1, MDM2, WHSC1L1
AKT1FAM175ANo2BRCA1, HSPA4
AKT1NBNNo14TOPBP1, MDM2, CASC3, HSPA4, RICTOR, SNAI1, MTOR, TERF2IP, SIRT1, MAPKAP1, PRKDC, BRCA1, EP300, SKP2
AKT1CDH1No17HSPA9, HSPA8, CTNNB1, MDM2, ILK, EP300, CREBBP, SMAD7, IQGAP1, PPP1CA, PTEN, HSP90AA1, EGFR, SRC, HSPA5, GSK3B, SKP2
AKT1CHEK2No14KAT2B, IL24, WHSC1L1, MDM2, VCP, PRKDC, PPP2CA, ENO1, NR4A1, APP, ST14, PPP2R1A, BRCA1, SIRT1
AKT1BRCA1Yes42AR, PIAS1, VCP, PPP2CA, EZH2, PPP1CA, CTBP1, SKP2, COMMD1, YBX1, ITPR1, SMARCC2, NPM1, DNAJB1, SMAD3, CTNNB1, DNMT1, FOXO3, YWHAZ, TOPBP1, ESR1, SMARCB1, PRKDC, HSP90AA1, NFE2L2, PPP1CB, AKT1, EP300, BRCA1, SMARCC1, CREBBP, FANCA, HSPA8, RICTOR, XIAP, MTOR, TUBB, CLK2, ENO1, MAPKAP1, CSNK2A1, PHB2
AKT1BRCA2No5KAT2B, BRCA1, SMAD3, SMAD2, NEDD4
AKT1BARD1No12CCDC88A, TOPBP1, PIAS1, ZHX1, COMMD1, NPM1, SETDB1, YWHAZ, ESR1, YBX1, BRCA1, SKP2
AKT1KRASNo10IL24, CALM1, SERPINB5, PIK3CA, OSGIN1, TRAF6, RAF1, SORBS3, THRSP, APP
AKT1TP53No74KAT2B, BCL2L1, PIAS1, ZHX1, VCP, PSMC5, YWHAE, DDX5, SRC, CREB1, VIM, APOH, HSP90AB1, HSPA5, CTBP1, STUB1, IQGAP1, TNK2, MDM2, TUBB, MAPK8, YBX1, GSK3B, MDH1, BRCA1, SMAD7, STK4, SKI, DNAJB1, SMAD3, DAB2IP, TBC1D4, DNMT1, MAPK14, APPL1, ALYREF, YWHAZ, HSPA9, SFN, PIAS2, GAPDH, PRKDC, SMARCB1, MAPK9, CLTC, SMAD2, IKBKB, MUL1, NR4A1, HSP90AA1, PTEN, NPM1, PPP2R1A, PPP3CA, EP300, FOXO3, KAT6A, SMARCC1, CREBBP, PPP1CC, HSPA8, SNAI1, CSNK2A1, HSPA4, ACTB, MTOR, CDKN1A, PPP1CA, CHUK, HSPB1, SIRT1, ESR1, TPM4, UCHL1
AKT1ESR1Yes71DDX5, PIAS1, PTEN, VCP, PRKCZ, PSMC5, TOPBP1, ESR1, FHL1, SRC, EZH2, NSF, EGFR, GNB1, SERPINB5, SFN, PAK1, SKP2, HSP90AA1, CLTC, TSC2, TUBB, KAT6A, YBX1, PA2G4, PPP2CA, MAPKAPK2, SKI, NCOR2, HDAC3, MDM2, SMAD3, STUB1, FOXO1, FOXO4, BRCA1, ALYREF, SIRT1, EPSTI1, CDKN1A, CALM1, CTNNB1, PIAS2, GAPDH, KRT10, PRKDC, SMAD2, ACTB, TRAF6, AKT1, NPM1, PPP2R1A, NCOA4, EP300, PPP1CC, WHSC1L1, FKBP5, PPIA, HSPA8, TBK1, HSPA4, IRS1, PPP1CA, CHUK, HSPB1, TCOF1, TSC1, PIK3CA, EIF4A1, CREBBP, PHB2
AKT1PHBNo16NF2, AR, HSP90AB1, VCP, CASC3, SKP2, YWHAE, CLTC, NPM1, ACTB, RAF1, YWHAZ, ESR1, ATP1A1, PHB2, ST14
AKT1PALB2No8IL13RA2, IL24, SNAI1, HIST2H2BE, SERPINB5, BRCA1, THRSP, MRC2
AKT1CASP8No19IL13RA2, S100A14, AGR3, IL24, WHSC1L1, PTEN, LRRK2, MAPK8, SERPINB5, XIAP, CHUK, IKBKB, TRAF6, EPSTI1, VIM, YBX1, ST14, CLIP3, CASC3
AKT1RAD51No9IL24, ST14, HSP90AA1, TERF2IP, VIM, TFF1, ESR1, BRCA1, WHSC1L1
AKT1PIK3CAYes12IL13RA2, IL24, AKT1, NOTCH1, IRS1, DDX5, ERBB3, SMAD2, ESR1, SMAD3, THRSP, APPL1
BRIP1XRCC3No2PMS2, MMS19
BRIP1RB1CC1No2VAPB, RPA1
BRIP1FAM175ANo2BRCA1, BARD1
BRIP1NBNNo6TOPBP1, MLH1, BARD1, RPA1, BLM, BRCA1
BRIP1CDH1No1LMNA
BRIP1CHEK2No1BRCA1
BRIP1BRCA1Yes9HNRNPC, TOPBP1, MLH1, BARD1, PMS2, RPA1, BLM, USP37, BRCA1
BRIP1BRCA2No6HNRNPC, BARD1, PMS2, RPA1, PMS1, BRCA1
BRIP1BARD1Yes5BARD1, BRCA1, TOPBP1, HNRNPC, MLH1
BRIP1KRASNo1HNRNPC
BRIP1TP53No5BRCA1, RPA1, BARD1, BLM, LMNA
BRIP1ESR1No5BARD1, BRCA1, TOPBP1, HNRNPC, MMS19
BRIP1PHBNo1LMNA
BRIP1PALB2No2BRCA1, HNRNPC
BRIP1CASP8No1BLM
BRIP1RAD51No5HNRNPC, BRCA1, BARD1, BLM, RPA1
XRCC3RB1CC1No6ITIH5, MRC2, GREB1, PSMC3IP, RNF20, BAP1
XRCC3PPM1DNo3OSGIN1, ITIH5, MRC2
XRCC3FAM175ANo1FANCG
XRCC3NBNNo2SNAI1, BAP1
XRCC3CDH1No1HSPD1
XRCC3CHEK2No7UBR5, BRCA2, ITIH5, FAM84B, PSMC3IP, RNF20, APP
XRCC3BRCA1No16HNRNPA2B1, PMS2, BRCA2, COPE, SSX2IP, BAP1, GPN1, ZC3H11A, DNAJA1, EIF5B, RAD51, HSPD1, MED17, ITIH5, PHB2, CDK9
XRCC3BRCA2Yes3PMS2, RAD51, FANCG
XRCC3BARD1No9CCAR1, UBR5, MED17, SNRNP70, NSRP1, CDK9, BRCA2, RBM17, RAD51
XRCC3KRASNo4OSGIN1, BCAS3, SERPINB5, APP
XRCC3TP53No21CCAR1, UBR5, TCP1, BRCA2, HSP90B1, UBR4, SNAI1, CKAP4, SF3B2, ATP5A1, SSX2IP, HNRNPA2B1, CCT8, RAD51, DNAJA1, HSP90AB1, MED17, RNF20, EIF5B, CCT3, CCT6A
XRCC3ESR1No25MED24, XPO1, MED16, MED17, SF3B1, PSMC3IP, HSP90B1, RPL10, HNRNPA2B1, FARSA, UNC45A, BCAS3, BAP1, SERPINB5, TECR, HSPD1, NCOA4, MMS19, FKBP5, CXCL1, GCN1L1, NCAPD3, RAD51, TRIM25, PHB2
XRCC3PHBNo7BCAS3, UQCRQ, TMPO, SSR3, XPO1, HSP90AB1, PHB2
XRCC3PALB2No8BRCA2, SERPINB5, SNAI1, FAM84B, MRC2, GREB1, BCAS3, RAD51
XRCC3CASP8No4PSMC3IP, BAP1, SERPINB5, GREB1
XRCC3RAD51Yes9BRCA2, TIMM13, ITIH5, FAM84B, HNRNPA2B1, RAD51, SWSAP1, RAD51C, TFF1
XRCC3PIK3CANo1PSMC3IP
RB1CC1PPM1DNo8ERRFI1, GLCE, UBC, EPSTI1, MRC2, LYPD3, ITIH5, WHSC1L1
RB1CC1RAD54LNo1SGTB
RB1CC1FAM175ANo1UBC
RB1CC1NBNNo3RPA1, BAP1, RPA2
RB1CC1CDH1No1CTNNB1
RB1CC1CHEK2No8VHL, IL24, ITIH5, TP53, LYPD3, PSMC3IP, RNF20, WHSC1L1
RB1CC1BRCA1No9PRKAA2, SMARCB1, HUWE1, RPA1, TP53, CTNNB1, UBC, ITIH5, BAP1
RB1CC1BRCA2No2TP53, RPA1
RB1CC1BARD1No4MOB4, TACC1, TP53, ERCC6L
RB1CC1KRASNo3IL24, THRSP, EEA1
RB1CC1TP53Yes15VHL, RPA2, PTK2, SAFB2, SMARCB1, RPA1, HUWE1, SAFB, CCDC8, TP53, RFWD2, SKI, UBC, TCEAL4, RNF20
RB1CC1ESR1No14HBP1, RBMX, TBK1, BAP1, SAFB2, GLCE, SAFB, SKI, SKIL, EPSTI1, TP53, CTNNB1, PSMC3IP, WHSC1L1
RB1CC1PHBNo4UBC, HUWE1, TP53, CCDC8
RB1CC1PALB2No7IL13RA2, IL24, ERRFI1, GREB1, LYPD3, THRSP, MRC2
RB1CC1CASP8No17IL13RA2, EPSTI1, BLID, GREB1, ERRFI1, LYPD3, HBP1, TP53, UBC, GLCE, BAP1, UMPS, TRAF2, PSMC3IP, VPS45, IL24, WHSC1L1
RB1CC1RAD51No7IL24, ITIH5, RPA1, TP53, UMPS, SGOL1, WHSC1L1
RB1CC1PIK3CANo5IL13RA2, THRSP, PSMC3IP, IL24, UMPS
PPM1DFAM175ANo1UBC
PPM1DNBNNo4H2AFX, MDM2, CDC5L, NAT2
PPM1DCDH1No1MDM2
PPM1DCHEK2No6MDM2, ITIH5, DIRAS3, LYPD3, RHOBTB2, WHSC1L1
PPM1DBRCA1No5KDM1A, UBC, H2AFX, RAD21, ITIH5
PPM1DBRCA2No2H2AFX, RAD21
PPM1DBARD1No1H2AFX
PPM1DKRASNo2OSGIN1, DIRAS3
PPM1DTP53No4KDM1A, UBC, H2AFX, MDM2
PPM1DESR1No6KDM1A, MDM2, EPSTI1, GLCE, H2AFX, WHSC1L1
PPM1DPHBNo1UBC
PPM1DPALB2No7CASZ1, ERRFI1, DIRAS3, NAT2, LYPD3, RHOBTB2, MRC2
PPM1DCASP8No6ERRFI1, EPSTI1, UBC, GLCE, LYPD3, WHSC1L1
PPM1DRAD51No4H2AFX, ITIH5, WHSC1L1, NAT2
PPM1DPIK3CANo1BEX2
RAD54LTP53No1HECW2
FAM175ANBNNo6BARD1, HSPA4, PAXIP1, MDC1, BRCA1, SUMO2
FAM175ACHEK2No2BRCA1, MDC1
FAM175ABRCA1Yes10BRE, BABAM1, BARD1, MDC1, UBC, UIMC1, PARP1, BRCA1, SUMO2, BRCC3
FAM175ABRCA2No5BRCC3, BRCA1, BARD1, BRE, FANCG
FAM175ABARD1Yes7BRE, BARD1, MDC1, UIMC1, PARP1, BRCA1, BRCC3
FAM175ATP53No9BRE, HSPA4, BARD1, MDC1, UBC, UIMC1, PARP1, BRCA1, BRCC3
FAM175AESR1No5PARP1, HSPA4, BRCA1, BARD1, UIMC1
FAM175APHBNo3PARP1, UBC, BRE
FAM175APALB2No1BRCA1
FAM175ACASP8No2PARP1, UBC
FAM175ARAD51No5BRCC3, BRCA1, BARD1, BRE, MDC1
NBNCDH1No4SKP2, EP300, MDM2, XRCC5
NBNCHEK2No11ATM, ATR, MDM2, MSH2, PRKDC, MDC1, MDM4, RAD50, RNF8, BRCA1, SIRT1
NBNBRCA1Yes38ATM, ATRIP, FANCD2, TERF1, MDC1, RAD50, RFC1, RECQL5, KAT5, H2AFX, SKP2, DCLRE1C, ATR, CCNE1, BACH1, EP300, MSH2, RPA1, RBBP8, TUBG1, BRCA1, BAP1, TOPBP1, RAD18, MRE11A, PRKDC, TERF2, BARD1, MSH6, SUMO2, UBE2D1, RICTOR, MTOR, BLM, UBE2N, MAPKAP1, MLH1, XRCC5
NBNBRCA2No9ATM, ATR, BACH1, FANCD2, BARD1, RPA1, MCPH1, BRCA1, H2AFX
NBNBARD1Yes18MSH6, TOPBP1, BACH1, KAT5, UBE2D1, H2AFX, UBE2N, MSH2, BARD1, MDC1, HIST1H3A, RBBP8, XRCC5, RAD50, BRCA1, MRE11A, SKP2, MLH1
NBNKRASNo1MED4
NBNTP53No34ATM, MDM2, H2AFX, SNAI1, MDC1, RPA1, BMI1, SNW1, TUBG1, ATR, BACH1, UBE2B, MSH2, RFC1, OFD1, RPA2, BRCA1, SIRT1, BARD1, KAT5, PRKDC, MSH6, EP300, CELA2B, WRN, HSPA4, UBE2N, MTOR, BLM, MDM4, NCL, ATRX, UBE2A, VRK1
NBNESR1No18TOPBP1, KAT5, MDM2, EP300, HSPA4, MSH2, BAP1, BARD1, XRCC5, RAD50, SIRT1, TUBG1, NCL, PRKDC, BRCA1, DDX1, H2AFX, SKP2
NBNPHBNo3ATF2, SKP2, CASC3
NBNPALB2No6BACH1, SNAI1, RBBP8, NAT2, BRCA1, HIST1H3A
NBNCASP8No3BLM, BAP1, CASC3
NBNRAD51No19ATM, FANCD2, ATRX, WRN, RAD18, MSH2, BARD1, BLM, RECQL5, MSH6, TERF2IP, MDC1, MCPH1, RPA1, NAT2, RPA3, BRCA1, H2AFX, TUBG1
NBNPIK3CANo1ATR
CDH1CHEK2No1MDM2
CDH1BRCA1No17XRCC5, HSPA8, CTNNB1, EZR, HDAC2, HDAC1, ACTG1, CREBBP, PPP1CA, JUP, HSP90AA1, CCNB1, HSPD1, POLR2E, EP300, E2F1, SKP2
CDH1BARD1No3POLR2E, SKP2, XRCC5
CDH1TP53No23MDM2, CRYAB, CDC42, HSPA5, IQGAP1, MYO6, EP300, SMAD7, LMNA, HSPA9, HDAC1, HSP90AA1, SET, RNF2, PTEN, SRC, GSK3B, HSPA8, PTTG1, CREBBP, HDAC2, PPP1CA, ECT2
CDH1ESR1No28PTEN, MDM2, HSPD1, KRT8, EGFR, ACTN4, SKP2, MYO6, CBLL1, CTNNB1, E2F1, HDAC1, ACTN1, KRT1, KRT18, HSP90AA1, JUP, SET, AP2M1, SRC, EP300, ANP32B, HSPA8, CREBBP, HDAC2, PPP1CA, POLR2E, XRCC5
CDH1PHBNo7ACTN1, HDAC1, RNF2, LMNA, C1QBP, E2F1, SKP2
CDH1CASP8No5CASP3, CRYAB, PTEN, GMNN, EZR
CDH1RAD51No3CASP3, CDC42, HSP90AA1
CDH1PIK3CANo1HDAC1
CHEK2BRCA1Yes22ATM, VCP, MAPK1, ITIH5, TP53, RAD50, PLK1, ATR, MSH2, BRCA1, PPP2R5C, ENO1, PRKDC, MDC1, PPP2CA, BRCA2, MAPK3, TP53BP1, KPNA2, RB1, CHEK2, CCAR2
CHEK2BRCA2Yes7ATM, KAT2B, ATR, PLK1, TP53, BRCA1, CHEK2
CHEK2BARD1No13UBR5, BRCA2, SRPK1, FOXK2, MSH2, STRAP, MAPK1, MDC1, TP53, RAD50, ELAVL1, SRPK2, BRCA1
CHEK2KRASNo7IL24, CCL5, PML, MAPK1, ELAVL1, DIRAS3, APP
CHEK2TP53Yes36ATM, KAT2B, MDC1, VCP, SRPK1, MAPK3, TP53, DAPK3, TP53BP1, RNF20, ATR, MDM2, MSH2, RCHY1, BRCA1, PPP2R5C, SIRT1, VHL, CUL4A, PRKDC, FOXK2, ELAVL1, NR4A1, TRIM28, PPP2R1A, PSME3, FOXK1, UBR5, BRCA2, PLK3, MAPK1, PLK1, RB1, CHEK2, PML, MDM4
CHEK2ESR1No21KLK9, SRPK2, VCP, PRMT2, SRPK1, PRKDC, MSH2, FOXK2, MAPK1, TP53, CUL1, POLR2L, MDM2, RAD50, WHSC1L1, PPP2CA, PPP2R1A, BRCA1, FOS, PSMC3IP, SIRT1
CHEK2PHBNo6RAB11A, VCP, CCL5, TP53, RB1, ST14
CHEK2PALB2No9IL24, BRCA2, CCL5, PRDM14, FAM84B, DIRAS3, LYPD3, BRCA1, RHOBTB2
CHEK2CASP8No12IL24, ST14, PRDM14, MAPK1, KLK9, TP53, RB1, WHSC1L1, CDH13, LYPD3, PSMC3IP, BEX1
CHEK2RAD51No13ATM, IL24, BRCA2, ST14, ITIH5, MSH2, TP53, MDC1, FAM84B, CDH13, BRCA1, PML, WHSC1L1
CHEK2PIK3CANo4BEX1, PSMC3IP, ATR, IL24
BRCA1BRCA2Yes29ATM, BRE, FANCD2, SHFM1, H2AFX, CCNA2, SP1, ATR, BACH1, RPA1, STAT5A, SMAD3, BRCA1, RAD21, PALB2, MORF4L1, BARD1, PMS2, TP53, PCNA, SMC3, CHEK2, BRCC3, HNRNPC, CDK2, FLNA, PLK1, POLH, RAD51
BRCA1BARD1Yes95PIAS1, HSPA14, UBE2K, BRE, TP53, SNRNP200, PGAM5, COMMD1, MSH2, CDKN2AIP, SNX3, SMC1A, UBXN1, MRE11A, UBE2N, DRG1, CNTN4, MDC1, RELA, RFC2, UBE3A, BRCA2, UBE2D1, SUPT5H, POLR2A, HIST1H2BG, ESR1, RNGTT, RAD51, PARG, GTF3C4, ATP1B3, POLR2H, ASH2L, SKP2, BACH1, PCBP2, HIST2H2AC, UBE2E1, PSMA7, CBX1, AURKA, BRD7, ND1, ATP1B1, FAM175A, PIAS4, KAT5, H2AFX, UBE2W, OLA1, CRIPAK, RBBP8, BRCA1, CSTF1, TOPBP1, MED17, MSH3, NPC2, UIMC1, COL1A1, TULP2, CBX5, CDK2, XRCC6, XIST, CSTF2, XRCC5, CDK1, UBE2E3, RAD50, CBX3, LGALS3, UBE2E2, UBE2D2, TCEB3, MLH1, NPM1, SRSF1, YWHAZ, CDK9, NBN, BARD1, UBE2D3, MTA2, PARP1, MSH6, BRIP1, POLR2E, BRCC3, HNRNPC, MAPK1, YBX1, FBXO5, FBXO44
BRCA1KRASNo4HNRNPC, MAPK1, DNAJA3, BCL2
BRCA1TP53Yes145PIAS1, RELA, UBE2K, TFAP4, SUPT6H, RPL28, DDB1, TRIM24, PCNA, PABPC1, UBE3A, MAP3K1, NCOA3, CSNK2B, RPA1, CDK8, FOXO3, SMARCC1, RPL21, BARD1, USP7, NCOA1, TP53, ABL1, GTF2I, GNL3L, BRCA2, CDK2, SKP1, FLNA, MAPK3, PIAS4, PLK1, BLM, ESR1, RAD51, ATM, MYC, NFYA, HNRNPA1, ERCC6, XRCC6, TFAP2C, MTOR, EBNA1BP2, ASH2L, KAT5, TUBG1, SP1, PRMT1, BACH1, RFC1, DNAJB1, NCOA2, NABP2, RPS27, RPS13, CDKN2A, VCP, HERC2, REV1, HSP90AA1, H2AFX, DNAJA1, AURKA, HDAC2, BRD7, MED21, UBC, RPL31, CHEK2, RBBP4, MSH2, HIF1A, BRE, RPS7, CDK1, MDC1, CSNK1D, HECTD3, MSH6, CCNA2, KDM1A, HNRNPA2B1, SUMO1, RBBP7, SMARCD2, SMAD3, ETS1, BRCA1, MED17, PPP1CA, HDAC1, PRKDC, CAPZB, EIF5B, EP300, SMARCA4, RPL3, TP53BP1, WDR48, TP63, CSNK2A1, CHEK1, GTF2H4, TPM3, RB1, RFC4, MNAT1, TPM1, HUWE1, SSX2IP, TFAP2A, YBX1, CDK7, CTBP1, ATR, BCL2, UIMC1, NPM1, SRSF1, DNMT1, PPP2R5C, SMARCB1, YWHAZ, VDR, UBE2N, IFI16, SMARCA5, TOP2A, MTA2, PARP1, RANBP9, TP73, BRCC3, GTF3C4, HSPA8, CREBBP, MAPK1, NINL, CCNH, TUBB, UBE2I, RPRD1A, PPP1R13B
BRCA1ESR1Yes126PIAS1, AKT1, SMC3, RPL28, NPM1, TRIM24, PGAM5, VCP, MSH2, NCOA3, POLR2D, CDK8, DHX9, RPL3, CTNNB1, BAP1, MKI67, SMC1A, RPL21, SUPT6H, BARD1, JUN, NCOA1, TP53, RELA, UBE3A, SKP1, FLNA, POLR2I, POLR2A, HIST1H2BG, ESR1, POLR2G, RAD51, MYC, HNRNPD, HNRNPA1, PGR, NOP2, NUMA1, EZH2, POLR2H, ASH2L, SKP2, SP1, PRMT1, SNX6, PIK3R1, NCOA2, HIST2H2AC, RPS13, SUZ12, HSP90AA1, SUPT16H, RUVBL2, HSPD1, H2AFX, AHR, HDAC2, TUBB, MED21, PHB2, RBBP4, HIF1A, PABPC1, NFYA, POLR2J, NRIP1, KAT5, KDM1A, POU2F1, RDX, CCND1, STAT5A, RBBP7, HNRNPA2B1, POLR2C, SMAD3, YBX1, BRCA1, TOPBP1, MED17, HDAC1, PRKDC, CAPZB, UIMC1, EP300, SMARCA4, FHL2, SMARCA2, CDK2, XRCC6, CEBPB, RSL1D1, MNAT1, XRCC5, PPP2CA, RAD50, CCNH, DDX54, CDK7, FLII, RPSA, SRSF1, TUBG1, NUP153, E2F1, EIF4G1, LMO4, NELFB, JUP, TOP2A, MTA2, PARP1, NAT10, RANBP9, CRIPAK, UBE2I, HNRNPC, HSPA8, RBM28, CREBBP, MAPK1, GNB2L1, PPP1CA, POLR2E
BRCA1PHBNo23AR, VCP, BRE, SUZ12, SKP2, OLA1, NPM1, E2F1, YWHAZ, ESR1, RBL1, EED, HDAC1, TP53, PARP1, SMARCA2, CDK2, HUWE1, RB1, SMARCA4, UBC, RBL2, PHB2
BRCA1PALB2Yes12HNRNPC, BRCA2, BACH1, MORF4L1, USP2, MORF4L2, HIST1H2BG, POLH, RBBP8, BRCA1, PALB2, RAD51
BRCA1CASP8No17BCL2, UBC, USP2, XIAP, MAPK1, BLM, TP53, CEBPB, MSN, RB1, CASP9, YBX1, MAP3K14, PARP1, HECTD3, EZR, BAP1
BRCA1RAD51Yes34ATM, BRE, PCNA, FANCD2, MDC1, RECQL5, H2AFX, TUBG1, SP1, SUMO1, MSH2, RPA1, HNRNPA2B1, CSNK2B, DNAJA3, BRCA1, ITIH5, BARD1, MORF4L1, RAD18, HSP90AA1, TP53, ABL1, MSH6, UBE2I, BRCC3, HNRNPC, BRCA2, CHEK1, PALB2, BLM, ESR1, NELFB, RAD51
BRCA1PIK3CANo8ATR, ESR1, LCK, HDAC1, PIK3R1, SMAD3, AKT1, STAT1
BRCA2BARD1Yes12BRE, CDK2, BACH1, H2AFX, BCCIP, BARD1, HNRNPC, TP53, RAD51, BRCA1, AURKB, BRCC3
BRCA2KRASNo1HNRNPC
BRCA2TP53Yes26KAT2B, ATM, BRE, TP53, AURKB, CCNA2, SP1, ATR, BACH1, RAD23A, PSMD6, RPA1, SMAD3, BRCA1, BARD1, SMAD2, PCNA, H2AFX, BRCC3, CDK2, FLNA, USP11, PLK1, SERPINH1, CHEK2, RAD51
BRCA2ESR1No15SP1, MGMT, SMAD2, CDK2, FLNA, BARD1, HNRNPC, SMC3, STAT5A, SMAD3, TP53, SERPINH1, BRCA1, H2AFX, RAD51
BRCA2PHBNo4MGMT, BRE, CDK2, TP53
BRCA2PALB2Yes9HNRNPC, BACH1, PALB2, USP11, PDS5B, POLH, BRCA1, MORF4L1, RAD51
BRCA2CASP8No1TP53
BRCA2RAD51Yes19SP1, ATM, FANCD2, XRCC3, MORF4L1, DMC1, BARD1, BRE, TP53, HNRNPC, MCPH1, PDS5B, RPA1, PCNA, BRCC3, BRCA1, H2AFX, RAD51, PALB2
BRCA2PIK3CANo3ATR, SMAD3, SMAD2
BARD1KRASNo4HNRNPC, MAPK1, ELAVL1, DDX50
BARD1TP53Yes60UBE2N, CDK1, PIAS1, RELA, UBE2K, FKBP3, CHD3, BRE, MDC1, PIAS4, BRD7, ZHX1, EWSR1, AURKB, ASH2L, MSH6, KAT7, BACH1, MTA2, MSH2, SRSF6, NPM1, SRSF1, BRCC3, MRPS22, YBX1, BRCA1, KPNB1, ESR1, YWHAZ, MED17, ING5, BARD1, KAT5, FOXK2, UBR5, ELAVL1, UIMC1, DCAF7, SRPK1, TRAPPC11, PARP1, H2AFX, UBE3A, MOV10, CCAR1, GTF3C4, BRCA2, AURKA, CDK2, XRCC6, WDR5, MAPK1, THRAP3, NFKBIA, TP53, TOP1, RBM39, WDR33, RAD51
BARD1ESR1Yes63GOLGA2, SRRM1, PIAS1, MTA2, XRCC6, CCNT1, SRSF2, SRSF5, TP53, THRAP3, RAD50, EWSR1, SRPK2, POLR2H, PGAM5, H2AFX, U2SURP, LUC7L3, DDX50, ASH2L, MSH2, SRSF6, CRIPAK, NPM1, SRSF1, SKP2, BRCA1, HIST2H2AC, ESR1, TOP1, SMC1A, MED17, RBM39, SRSF7, MAPK1, BARD1, SRRM2, FOXK2, SRPK1, AKAP8, UIMC1, RELA, PARP1, BCL3, RPS20, UBE3A, POLR2B, HNRNPC, TOPBP1, LRIF1, KAT5, CDK2, WDR5, U2AF2, TCERG1, YBX1, CIRBP, POLR2A, HIST1H2BG, RAD51, BCLAF1, POLR2E, XRCC5
BARD1PHBNo10BRE, CDK2, OLA1, GTF3C1, TP53, YWHAZ, ESR1, NPM1, PARP1, SKP2
BARD1PALB2No9HNRNPC, BRCA2, BACH1, RBBP8, MOV10, HIST1H2BG, HIST1H3A, BRCA1, RAD51
BARD1CASP8No6TRAF1, CHD3, MAPK1, YBX1, TP53, PARP1
BARD1RAD51Yes14MSH6, HNRNPC, BRE, BRCA2, H2AFX, CHD3, BARD1, RAD51, TP53, MDC1, ESR1, BRCA1, MSH2, BRCC3
BARD1PIK3CANo3WDR5, RPS20, ESR1
KRASTP53No9PHB, CCT7, BCL2, PML, MAPK1, ELAVL1, BTRC, EEF1A1, LIMA1
KRASESR1No11PHB, HNRNPC, CALM1, DDX50, MAPK1, PIK3CA, PIK3R2, TRAF6, BCAS3, SHOC2, SERPINB5
KRASPHBYes3BCAS3, CCL5, RAF1
KRASPALB2No7HNRNPC, BCAS3, CCL5, IL24, SERPINB5, DIRAS3, THRSP
KRASCASP8No7RALGDS, BCL2, QDPR, MAPK1, IL24, SERPINB5, TRAF6
KRASRAD51No5HNRNPC, PML, IL24, ZDHHC17, DNAJA3
KRASPIK3CAYes4THRSP, TNFSF13, IL24, PIK3R2
TP53ESR1Yes211DDX5, PIAS1, TDG, RPL18A, SUPT6H, TRRAP, RPL28, RPL6, TRIM24, HDAC9, TOP2B, SNRPN, VCP, RPL5, TTK, NCOA3, SKI, CDK8, RBBP5, RPL12, DNMT3L, TOP1, SETD7, HECTD1, G3BP1, BARD1, MYO1C, RPL4, RPS4X, NCOA1, TP53, RELA, RPL11, PRDM2, UBE3A, HIF1A, EP400, PPP1CC, CORO1C, SKP1, FLNA, ANXA2, GNL3, ZBTB16, SFN, RPS2, WDR5, RPL7, RPS26, NFYA, HNRNPA1, IGF1R, EHMT2, RPS8, RRP1B, SAFB, THRAP3, OTUB1, SLC25A5, EWSR1, ARID1A, ASH2L, STUB1, SP1, CLTC, PRMT1, HSP90B1, GTF2H1, GSN, DDX3X, RPL8, RPS16, KAT6A, HSPB1, RPL3, DBN1, HDAC5, YTHDF1, RPS14, HEXIM1, PSMC5, KDM1A, PPARGC1A, ESR1, PIAS2, GAPDH, SIN3A, EIF2S2, RPLP0, HSP90AA1, ACTB, RBBP6, SRPK1, SMURF1, H2AFX, RPL24, RPL7A, MYO6, RBX1, RPS24, HDAC2, RPL23A, TUBB, GADD45A, MED21, RAD51, SERPINH1, RBBP4, MSH2, RPL18, HNRNPK, SIN3B, PABPC1, SRSF6, PARP1, TADA3, RPS6, RPL19, KAT5, RANBP9, CHUK, PHB, RPS18, TFRC, KLF5, HNRNPF, GRWD1, RBBP7, HNRNPA2B1, TUBA1A, SMAD3, MYBBP1A, BRCA1, SIRT1, MED17, SERBP1, RPL14, HDAC1, FOXK2, CCT2, CAPZB, TXNRD1, SET, PTEN, PPP2R1A, TAF1B, EP300, SMARCA4, SMARCD1, NR0B2, CDK2, G3BP2, MEN1, XRCC6, MYH9, PATZ1, RBM39, MNAT1, GNB2, RPS13, SMYD2, MDM2, TBP, MAPK1, S100A8, NCOR1, SAFB2, RPS3, RPS9, CCNH, CDK7, EEF2, MUC1, TAF1A, UIMC1, HNRNPM, NPM1, NCOA2, SRSF1, COPS5, MVP, HSPA1L, TUBA1C, RPL13, NCL, CDKN1A, GTPBP4, PRKDC, RPL21, RPL10A, ALYREF, RPS3A, TOP2A, SMAD2, MTA2, SRC, RPL37A, UBE4B, MYC, HSPA8, CREBBP, MTA1, HSPA4, MED1, YBX1, PPP1CA, MRPS9, SP3, UBE2I, ING1, TUBG1
TP53PHBYes33BRE, HSP90AB1, VCP, HUWE1, YWHAE, TP53, RPS4X, SLC25A5, TAT, NCOR1, CLTC, PRKCD, NPM1, SMG5, LMNA, HDAC5, ESR1, YWHAZ, OBSL1, DBN1, HDAC1, SIN3A, RNF2, ACTB, PARP1, CDK2, ANXA2, CCDC8, RB1, RPL7, SMARCA4, UBC, CUL7
TP53PALB2No8CAPN1, BRCA2, BACH1, SNAI1, USP11, MOV10, BRCA1, RAD51
TP53CASP8Yes28TNFAIP3, TOPORS, BAX, TP53, VIM, CFLAR, HECTD3, CHUK, MAPK8, MAP1LC3B, PARK7, BLM, RNF34, BIRC6, CHD3, SQSTM1, CRYAB, SNRPD3, IKBKB, PTEN, PARP1, CASP8, BCL2, MAPK1, TSC22D3, YBX1, RB1, UBC
TP53RAD51Yes33ATM, USP10, PCNA, CHD3, BRE, MDC1, VIM, H2AFX, TUBG1, SP1, SUMO1, MSH2, BLM, RPA1, HNRNPA2B1, CSNK2B, BRCA1, BARD1, HSP90AA1, TP53, ABL1, MSH6, UBE2I, BRCC3, BRCA2, WRN, CHEK1, UHRF2, ESR1, CDC42, ATRX, PML, RAD51
TP53PIK3CANo16UFD1L, DDX5, ESR1, CRK, GSN, HRAS, PCBP1, WDR5, SMAD2, ATR, SMAD3, IRS4, DNAJB6, APPL1, HDAC1, SQSTM1
ESR1PHBYes37ATP5B, VCP, TP53, SUZ12, MYOD1, RPS4X, MTCH2, SLC25A5, SKP2, MED20, CLTC, PHB2, NPM1, SYNCRIP, NCOR1, DBN1, HDAC5, HDAC1, BCAS3, ESR1, ACTN1, MED23, SIN3A, MGMT, ACTB, XPO1, PARP1, PLEC, E2F1, STAU1, SMARCA2, CDK2, FUS, ANXA2, RPL7, SMARCA4, CUL3
ESR1PALB2No7HNRNPC, BCAS3, SERPINB5, HIST1H2BG, CUL3, BRCA1, RAD51
ESR1CASP8No24ARHGDIA, TP53, CHUK, NR1H4, KLK9, KLK5, KHDRBS1, HDAC7, BAP1, HBP1, SERPINB5, GLCE, TRAF6, PTEN, PARP1, PSMC3IP, WHSC1L1, MAPK1, YBX1, CEBPB, EPSTI1, ATAD2, ANGPTL4, CUL3
ESR1RAD51Yes18SP1, UBE2I, FBXO18, PFN1, H2AFX, MSH2, BARD1, RAD51, TP53, HNRNPA2B1, HNRNPC, ELMSAN1, TUBG1, ESR1, NELFB, HSP90AA1, BRCA1, WHSC1L1
ESR1PIK3CAYes15DDX5, SMAD2, AKT1, HDAC1, GSN, UBTF, PIK3R2, PSMC3IP, PIK3R1, SMAD3, IRS1, ESR1, IRS2, RPS20, WDR5
PHBPALB2No3BCAS3, CCL5, CUL3
PHBCASP8No8TP53, UBC, RB1, CUL3, ST14, PARP1, BCAP31, CASC3
PHBRAD51No5RAB5C, BRE, ESR1, ST14, TP53
PHBPIK3CANo4NTRK1, HDAC1, KRAS, ESR1
PALB2CASP8No9IL13RA2, IL24, ERRFI1, SERPINB5, CUL3, GREB1, LYPD3, PRDM14, USP2
PALB2RAD51Yes12IL24, BRCA2, MORF4L1, PALB2, HNRNPC, FAM84B, PDS5B, CST6, NAT2, BRCA1, RAD51AP1, RAD51
PALB2PIK3CANo3IL13RA2, IL24, THRSP
CASP8RAD51No10IL24, UMPS, CHD3, TP53, CASP3, BLM, VIM, CDH13, WHSC1L1, ST14
CASP8PIK3CANo8IL13RA2, TNFRSF1A, FASLG, BEX1, UMPS, PSMC3IP, IL24, SQSTM1
RAD51PIK3CANo4UMPS, IL24, BUB1, ESR1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
ATMTP53Yes0
NQO2KRASYes1KRAS
BRCA1TP53No2CREBBP, EP300
BRCA1RAD51Yes0
KRASTP53No1EXOSC4
KRASCASP8No1NOL3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
TSG101HMMRNo-2AR, TP53
TSG101NQO2No-1UBC
TSG101AKT1No-12CDKN1A, KRAS, MDM2, AR, RPS27A, TP53, SOS1, USP8, UBC, GRB2, UBB, NEDD4
TSG101BRIP1No-1UBC
TSG101RB1CC1No-2UBC, TP53
TSG101PPM1DNo-3UBC, TP53, MDM2
TSG101FAM175ANo-1UBC
TSG101CDH1No-7AR, MDM2, HGS, TP53, EGF, EGFR, UBC
TSG101CHEK2No-4UBC, CDKN1A, MDM2, TP53
TSG101BRCA1No-5TP53, UBC, CDKN1A, AR, PABPC1
TSG101BRCA2No-2AR, TP53
TSG101BARD1No-2UBC, TP53
TSG101KRASYesbinding6SOS1, EGF, TP53, EGFR, UBC, GRB2
TSG101TP53Yesactivation, binding12MAP9, RPS27A, MDM2, NR3C1, AR, UBA52, CDKN1A, KRAS, EGFR, UBC, UBB, CEP55
TSG101SLC22A18No-1UBC
TSG101ESR1No-9CDKN1A, MDM2, NR3C1, AR, TP53, SOS1, EGFR, UBC, GRB2
TSG101PHBNo-2UBC, TP53
TSG101RAD51No-1TP53
TSG101PIK3CANo-8AR, KRAS, NR3C1, TP53, SOS1, EGFR, EGF, GRB2
HMMRAKT1No-6AR, SLC9A1, HRAS, AURKA, TP53, CD44
HMMRRB1CC1No-1TP53
HMMRPPM1DNo-1TP53
HMMRCDH1No-4CD44, MTA1, AR, TP53
HMMRCHEK2No-1TP53
HMMRBRCA1No-4AR, AURKA, TP53, BACH1
HMMRBRCA2No-2AR, TP53
HMMRBARD1No-3AURKA, TP53, BACH1
HMMRKRASNo-2HRAS, TP53
HMMRTP53Yesbinding, activation, expression6AR, HRAS, AURKA, MTA1, CSNK1A1, CD44
HMMRESR1No-3AR, MTA1, TP53
HMMRPHBNo-1TP53
HMMRRAD51No-1TP53
HMMRPIK3CANo-3HRAS, AR, TP53
NQO2AKT1No-1UBC
NQO2BRIP1No-1UBC
NQO2RB1CC1No-1UBC
NQO2PPM1DNo-1UBC
NQO2FAM175ANo-1UBC
NQO2CDH1No-1UBC
NQO2CHEK2No-1UBC
NQO2BRCA1No-1UBC
NQO2BARD1No-1UBC
NQO2KRASNo-1UBC
NQO2TP53No-1UBC
NQO2SLC22A18No-1UBC
NQO2ESR1No-1UBC
NQO2PHBNo-1UBC
AKT1BRIP1No-4UBC, BRCA1, TOPBP1, FOXM1
AKT1RB1CC1No-8RPS6KB1, MLST8, SMAD7, RPTOR, MTOR, RB1, TP53, UBC
AKT1PPM1DNo-10BCL2L1, MDM2, RUNX2, CHEK1, TP53, JUN, UBC, MAPK14, PAK1, MDM4
AKT1FAM175ANo-2UBC, BRCA1
AKT1CDH1Yesactivation, binding80ZYX, CDH2, FOXM1, SNAI2, POSTN, ACTA1, TP53, SNAI1, RAC1, SMAD4, CAV1, FOXA2, GLI2, SERPINE1, CTGF, FOXO3, EZR, FOS, FGF2, SKP2, PTGS2, IQGAP1, CD44, PDCD4, ITGA6, ITGB4, NFKB1, RHOA, SMAD7, PIK3R1, PIK3CA, RAP1A, HDAC9, SMAD3, CTNNB1, TGFB1, ERBB3, LEP, CDC42, WT1, NOTCH1, STAT5A, RAP1B, GLI1, MDM2, F2R, AR, SLC3A2, IQGAP2, GAB2, IGF1, RPS6KB1, JUN, VAV1, PTEN, SRC, EP300, EFNA1, DLC1, STAT3, SMAD2, FGF13, RPTOR, BCL2, ILK, RICTOR, PRKCZ, MMP9, IGF2, RB1, TJP1, STAT5B, RAC3, EZH2, UBC, IRS2, MYC, CCND1, NOX1, FOXA1
AKT1CHEK2No-15KAT2B, CDKN1A, MDM2, FOXM1, CHEK1, YWHAH, PPP2CA, TP53, MDM4, RB1, YWHAZ, SFN, UBC, BRCA1, CDC25C
AKT1BRCA1Yesbinding38AR, TERF1, TOPBP1, TP53, NPM1, BMI1, PCGF2, SKP2, CCND1, RB1, CREB1, STAT5A, SMAD3, CCNA2, CTNNB1, E2F1, SIRT1, CDKN1A, ESR1, HSP90AA1, JUN, ATF2, RELA, SRC, EP300, FANCA, HSPA8, UBE2D1, CREBBP, AURKA, PPP1CA, GADD45A, PIK3R1, HIF1A, CCNB1, UBC, MYC, CDKN1B
AKT1BRCA2No-9AR, C11ORF30, CHEK1, FANCA, TP53, STAT5A, SMAD3, BRCA1, SNAI2
AKT1BARD1No-10TOPBP1, UBE2D1, AURKA, FANCA, TP53, ESR1, UBC, BMI1, PCGF2, BRCA1
AKT1KRASYesactivation, binding40BCL2L1, PTPN11, TP53, SPHK1, NPM1, PIK3CG, LGALS3, VEGFA, YWHAB, HSP90AA1, GRB2, ANGPT1, BCL2, CCND1, PIK3CA, ERBB3, RAF1, SOS1, SHC1, AKT2, SLC3A2, HRAS, RALGDS, BTRC, RPS6KB1, JUN, PPP2CA, CTGF, SRC, BCL2L11, MAPK14, NOTCH1, PIK3CB, MTOR, IRS2, UBC, IRS1, PIK3CD, BRAF, MDM4
AKT1TP53Yesbinding, activation, expression139WWOX, RELA, CAV1, NPM1, HDAC9, VEGFA, FOXO3, HTT, CXCL12, STAT5A, COPS5, MAPK14, BAX, BDNF, JUN, NR4A1, FOXM1, MMP9, MTOR, MCL1, YWHAG, ESR1, KAT2B, BCL2L1, RUNX2, YWHAE, IGFBP3, SERPINE1, FGF2, STUB1, PTGS2, PIAS2, EGR1, PARK7, THBS1, RB1, CAT, CCNA2, SFN, TSC2, GAPDH, AR, CDH1, ANKRD2, HSP90AA1, LGALS3, AURKA, TERT, MMP2, GADD45A, S100B, MDM4, CCNB1, UBC, HIF1A, SP7, MMP1, SLC2A4, SMAD4, BTRC, CREB1, CFLAR, HSPA5, FOS, NCOR1, PHB, NOS3, PHF20, GDF15, NFKB1, CCND1, CD44, KRAS, BMI1, AXIN1, SMAD3, RAF1, BRCA1, SIRT1, WT1, BIRC5, FOXO1, HSPB3, HRAS, NOTCH1, SMAD2, NFE2L2, PTEN, PPP2R1A, ICAM1, EP300, SHH, UBE2D1, CHEK1, EZH2, RUNX3, APAF1, HMOX1, CDC25C, PTPN11, MDM2, HSPB2-C11ORF52, SNAI1, TOPBP1, SNAI2, WEE1, BAIAP2L1, UBB, RPS27A, BCL2, SMAD7, PPP2R4, PIK3CA, CLU, DNMT1, SKP2, TGFB1, PPP2R5C, YWHAZ, CDKN1A, SERPINH1, TRAF6, STAT5B, CTGF, PARP1, GSK3B, MYC, STAT3, HSPA8, POLI, CREBBP, HSPA4, IKBKB, YBX1, IL6, ATIC, LEP, MAP3K8, PDCD4
AKT1SLC22A18No-1UBC
AKT1ESR1Yesactivation, binding84MYC, AR, PELP1, PTEN, MDM2, RRAS2, RAC3, EZH2, CDKN1A, TP53, NOS3, SRC, CAV1, MAPK14, ATF2, SOS1, GNB1, CTGF, NRIP1, HDAC9, FOS, VEGFA, STUB1, PHB, GNAI3, PTGES3, FOXO3, RXRG, FOXM1, STRN, GNAO1, GNAI1, CXCL12, MAPT, HDAC3, PIK3CA, NCOR2, STAT5A, SMAD3, NCOR1, SMAD2, COPS5, SHC1, FOXO4, SIRT1, TSC2, AKT2, FOXO1, SOD1, GAPDH, TERT, STAT3, RARA, MYOD1, HSP90AA1, JUN, NR4A1, SMAD4, RELA, RHOA, PARP1, PAK1, EP300, BRCA1, E2F1, FKBP5, FKBP4, HSPA8, CREBBP, HSPA4, SNAI2, FASN, HEXIM1, INS, IL6, PIK3R1, GNAZ, IGF1, UBC, IRS1, GRB2, LEP, CCND1, FOXA1
AKT1PHBYesbinding, ptmod9RAF1, TP53, RB1, NCOR1, ESR1, UBC, E2F1, VDAC1, YWHAZ
AKT1PALB2No-1BRCA1
AKT1RAD51No-8EGR1, FOXM1, CHEK1, IRS1, POLI, TP53, BRCA1, BCR
AKT1PIK3CAYesactivation, binding108ITGB3, PTEN, PLCG1, TP53, CDC42, SOS1, RAP1A, PDGFB, ACTN4, PDGFRB, ACTA1, CTNNB1, GNGT1, BECN1, BDNF, PIK3CB, RELA, CBLB, RELN, IL2, RRAS2, MTOR, INS, JAK1, PIK3R5, GNB1, ESR1, VAV2, FLT3, BCL2L1, AKT2, ITGA2B, RPTOR, PGF, ANGPT2, ITGA6, RHOA, PREX1, PIK3R1, BCR, RPS6KB2, APPL1, IGF1, PTPN1, CDH1, PIK3R3, PDPK1, ITGB4, GRB2, GAB1, PIK3CD, ZYX, PELP1, VLDLR, AR, CSK, TPTE2, RAP1B, DAB1, INSR, GSK3B, CCND1, CREB1, SMAD3, RAF1, ERBB3, TPTE, LCK, HRAS, NOTCH1, GAB2, DOK1, CDH2, VEGFA, RAC1, RICTOR, PRKCZ, GNAI3, CASP9, IL2RB, EFNA1, RAC3, PTPN11, MAP3K5, PIK3CG, GNAI1, DAB2IP, ANGPT1, RRAS, SHC1, YWHAZ, CSF2, TSC1, S1PR1, SLC9A3R1, SMAD2, SRC, NFKB1, MYC, STAT3, KRAS, IL3, ARF6, RPS6KB1, IRS1, VAV1, IRS2, LAT
BRIP1XRCC3No-3BLM, BRCA2, MLH1
BRIP1RB1CC1No-1UBC
BRIP1PPM1DNo-1UBC
BRIP1RAD54LNo-1BLM
BRIP1FAM175ANo-2UBC, BRCA1
BRIP1CDH1No-2UBC, FOXM1
BRIP1CHEK2No-5UBC, BRCA1, BRCA2, FOXM1, PLK1
BRIP1BRCA1Yesbinding8TOPBP1, BRCA2, PALB2, RPA1, BLM, PLK1, UBC, MLH1
BRIP1BRCA2Yesbinding7PALB2, RPA1, BLM, PLK1, BRCA1, TOP3A, MLH1
BRIP1BARD1No-3UBC, BRCA1, TOPBP1
BRIP1KRASNo-1UBC
BRIP1TP53No-11TOPBP1, BRCA2, FOXM1, ERCC2, MLH1, PMS2, RPA1, BLM, PLK1, UBC, BRCA1
BRIP1SLC22A18No-1UBC
BRIP1ESR1No-3UBC, BRCA1, FOXM1
BRIP1PHBNo-1UBC
BRIP1PALB2Yesbinding2BRCA1, BRCA2
BRIP1RAD51No-10PMS2, BRCA2, FOXM1, PALB2, RPA1, BLM, PLK1, BRCA1, TOP3A, MLH1
XRCC3PPM1DNo-0
XRCC3RAD54LYesbinding8WRN, DMC1, BLM, RAD51, RAD51C, RECQL, RAD51B, RAD51D
XRCC3FAM175ANo-0
XRCC3CHEK2No-3RAD52, BRCA2, WRN
XRCC3BRCA1No-11ACACA, BRCA2, MLH1, BLM, FANCG, RAD51C, RAD51B, POLH, DMC1, RAD51, FANCD2
XRCC3BRCA2Yesactivation, binding9FANCD2, RAD51D, MLH1, BLM, FANCG, RAD51C, RAD51B, DMC1, RAD51
XRCC3BARD1No-3FANCD2, RAD51, FANCG
XRCC3TP53No-6BRCA2, WRN, MLH1, BLM, POLH, RAD51
XRCC3PALB2No-4FANCD2, BRCA2, RAD51, RAD51C
XRCC3RAD51Yesbinding16FBXO18, BRCA2, BLM, WRN, MLH1, DMC1, ACACA, TTF2, RAD54B, ACACB, REV1, RAD52, RAD54L, POLH, RECQL, RAD51C
RB1CC1PPM1DNo-2UBC, TP53
RB1CC1FAM175ANo-1UBC
RB1CC1CDH1No-6RPS6KB1, SMAD7, RPTOR, TP53, RB1, UBC
RB1CC1CHEK2No-3UBC, RB1, TP53
RB1CC1BRCA1No-4UBC, SMARCB1, RB1, TP53
RB1CC1BRCA2No-1TP53
RB1CC1BARD1No-2UBC, TP53
RB1CC1KRASNo-5MTOR, UBC, RPS6KB1, PTK2, TP53
RB1CC1TP53Yesactivation, binding8PTK2B, SMAD7, PIAS4, MTOR, RB1, PTK2, UBC, SMARCB1
RB1CC1SLC22A18Yesbinding1UBC
RB1CC1ESR1No-2UBC, TP53
RB1CC1PHBNo-3UBC, RB1, TP53
RB1CC1RAD51No-1TP53
RB1CC1PIK3CANo-5MTOR, RPTOR, RPS6KB1, TP53, PTK2
PPM1DFAM175ANo-2UBC, H2AFX
PPM1DCDH1No-5UBC, JUN, MAPK3, TP53, MDM2
PPM1DCHEK2Yesbinding, ptmod6MDM2, CHEK1, TP53, UBC, H2AFX, MDM4
PPM1DBRCA1No-5UBC, CHEK2, H2AFX, JUN, TP53
PPM1DBRCA2No-4CHEK2, CHEK1, H2AFX, TP53
PPM1DBARD1No-3UBC, H2AFX, TP53
PPM1DKRASNo-10BCL2L1, MAPK11, MAPK3, TP53, JUN, MAPK13, UBC, MAPK14, MAPK12, MDM4
PPM1DTP53Yesactivation15BCL2L1, MAPK11, RUNX2, CHEK1, MAPK3, MAPK13, JUN, MAPK12, MDM2, UBC, CHEK2, H2AFX, HIPK2, MAPK14, MDM4
PPM1DSLC22A18No-1UBC
PPM1DESR1No-8MDM2, MAPK11, MAPK3, TP53, JUN, UBC, MAPK14, PAK1
PPM1DPHBNo-2UBC, TP53
PPM1DRAD51No-3H2AFX, CHEK1, TP53
PPM1DPIK3CANo-2BCL2L1, TP53
RAD54LCHEK2No-2MUS81, WRN
RAD54LBRCA1No-5RAD51B, BLM, RAD51, DMC1, RAD51C
RAD54LBRCA2No-7RAD51D, DMC1, BLM, RAD51, XRCC3, RAD51B, RAD51C
RAD54LBARD1No-1RAD51
RAD54LTP53No-3BLM, RAD51, WRN
RAD54LPALB2No-2RAD51, RAD51C
RAD54LRAD51Yesbinding6WRN, DMC1, BLM, XRCC3, RECQL, RAD51C
FAM175ACDH1No-1UBC
FAM175ACHEK2No-6TP53BP1, RAD50, UBC, BRCA1, H2AFX, RNF8
FAM175ABRCA1Yesbinding10BRE, BABAM1, BARD1, TP53BP1, UIMC1, RAD50, UBC, H2AFX, SUMO2, RNF8
FAM175ABRCA2No-2BRCA1, H2AFX
FAM175ABARD1Yesbinding7BRE, BABAM1, UIMC1, RAD50, UBC, BRCA1, H2AFX
FAM175AKRASNo-1UBC
FAM175ATP53No-7BARD1, TP53BP1, UIMC1, UBC, BRCA1, SUMO2, H2AFX
FAM175ASLC22A18No-1UBC
FAM175AESR1No-3UBC, BRCA1, BARD1
FAM175APHBNo-2UBC, BRE
FAM175APALB2No-1BRCA1
FAM175ARAD51No-6BRE, BARD1, TP53BP1, BRCA1, SUMO2, H2AFX
CDH1CHEK2No-6VHL, FOXM1, MDM2, TP53, RB1, UBC
CDH1BRCA1No-27AR, AKT1, TP53, ANAPC11, CTBP1, SKP2, SUMO1, CCND1, RB1, CDC27, STAT5A, SMAD3, CTNNB1, CDC23, HDAC1, JUN, ABL1, SRC, EP300, FHL2, ANAPC7, HDAC2, CBX7, PIK3R1, SMARCA4, UBC, MYC
CDH1BRCA2No-5TP53, SNAI2, SMAD3, STAT5A, AR
CDH1BARD1No-7ANAPC7, TP53, CBX7, CDC27, ANAPC11, UBC, CDC23
CDH1KRASNo-31AKT1, BMP4, MAPK3, RET, TP53, EGFR, CTGF, IGF2BP1, BCL2, CCND1, PIK3CA, EPHA2, ERBB2, ERBB3, KIT, IRS2, SLC3A2, PRMT5, UBC, RPS6KB1, IL8, ABL1, SRC, FYN, YES1, NOTCH1, MAPK1, JUN, CDX1, CDX2, EGF
CDH1TP53Yesactivation, binding83PKD1, VHL, AR, ABL1, FOXM1, BCL2, MET, MAPK3, ZEB2, SNAI1, HOXA10, TWIST1, SMAD4, CAV1, RGCC, MTA3, NRP2, SERPINE1, CTGF, HDAC9, FOS, FGF2, SKP2, PTGS2, CD44, ID2, MDM2, SUMO1, CTCF, NFKB1, KLF5, SMAD7, RB1, PIK3CA, EPHA2, ERBB2, SMAD3, FHL2, CD82, TGFB1, TGM2, NUMB, WT1, PPARGC1A, STAT5A, CA9, HGF, MAPK1, CCNG1, HDAC1, PRMT5, STAT3, SMAD2, JUN, S100A4, PSEN1, AKT1, SIK1, HMGA2, EP300, FOXO3, SNAI2, NOTCH1, EGFR, MYO6, SIRT3, STAT5B, CCND1, IGF1R, MTA1, HDAC2, EZH2, CTBP1, MMP9, PTEN, SMARCA4, UBC, MYC, LEP, PPARG, KLF4, PDLIM7, PDCD4
CDH1SLC22A18No-1UBC
CDH1ESR1No-53AR, ABL1, FOXM1, HDAC2, TP53, MAPK1, TWIST1, CAV1, EGFR, CTGF, HDAC9, FOS, MDM2, SUMO1, CTBP1, RHOA, ERBB2, PIK3CA, MTA1, SMAD3, CD82, MACROD1, FOXO3, GNA13, PPARGC1A, STAT5A, IGF1, ESR2, HDAC1, SMAD2, JUN, SMAD4, AKT1, SRC, MTA3, EP300, LEP, SNAI2, STAT3, WNT7A, IGF1R, MAPK3, EZH2, PIK3R1, PTEN, FOXA1, SMARCA4, UBC, MYC, CCND1, PPARG, KLF5, RAC3
CDH1PHBNo-6AKT1, HDAC1, TP53, RB1, SMARCA4, UBC
CDH1RAD51No-5SUMO1, TP53, FOXM1, SMARCA4, ABL1
CDH1PIK3CAYesactivation, binding58RAC1, CDH2, MET, CD2AP, RET, ZYX, VCL, ACTN1, CTNND1, CDC42, EGFR, RAP1B, DLG1, HGF, ITGA6, GFRA1, ITGB4, RHOA, ACTA1, CTNNA1, RAP1A, EPHA2, ERBB2, SMAD3, TLN1, CTNNB1, ERBB3, KIT, PRKCA, PRKCI, AR, NOTCH1, GAB2, TP53, RPS6KB1, SMAD2, AKT1, SRC, FYN, NFKB1, EFNA1, YES1, STAT3, GDNF, IL4, RICTOR, VAV1, PRKCZ, RPTOR, PIK3R1, PTEN, IGF1, EGF, IRS2, MYC, CCND1, IGF1R, RAC3
CHEK2BRCA1Yesactivation, binding15TP53BP1, ATR, TREX1, MSH2, TOP2A, CDKN1A, PLK1, RB1, RAD50, TP53, UBC, BRCA2, H2AFX, TP73, RNF8
CHEK2BRCA2Yesbinding, ptmod7ATR, TREX1, CHEK1, PLK1, TP53, H2AFX, BRCA1
CHEK2BARD1No-7ATR, MSH2, TP53, RAD50, UBC, H2AFX, BRCA1
CHEK2KRASNo-4UBC, TP53, PPP2CA, MDM4
CHEK2TP53Yesactivation, binding33KAT2B, PLK3, TREX1, MDM2, CHEK1, CDC25A, TP53BP1, ATR, FOXM1, MSH2, PPM1D, RCHY1, BRCA1, YWHAZ, VHL, CDKN1A, ELAVL1, TOP2A, H2AFX, BRCA2, TP63, WRN, CABIN1, ASF1A, PLK1, KPNA2, RB1, MDM4, SFN, UBC, TP73, PML, CDC25C
CHEK2SLC22A18No-1UBC
CHEK2ESR1No-7CDKN1A, MDM2, FOXM1, MSH2, TP53, UBC, BRCA1
CHEK2PHBNo-4UBC, RB1, TP53, YWHAZ
CHEK2PALB2No-2BRCA1, BRCA2
CHEK2RAD51No-11TP53BP1, BRCA2, FOXM1, WRN, MSH2, CHEK1, PLK1, TP53, RAD52, H2AFX, BRCA1
CHEK2PIK3CANo-2TP53, YWHAZ
BRCA1BRCA2Yesbinding32AR, TREX1, H2AFX, FANCD2, SHFM1, TEX15, HIST3H3, RPA3, RAD51B, ATR, MLH1, RAD51, RPA1, STAT5A, SMAD3, RPA2, PALB2, FANCI, DMC1, TP53, PSMC3IP, BRIP1, FANCA, CDK2, CDK4, BUB1B, PLK1, BLM, FANCG, MND1, CHEK2, RAD51C
BRCA1BARD1Yesbinding65ANAPC4, CDC26, ANAPC11, UBE2L3, H2AFX, AURKA, FANCD2, BRE, ANAPC15, FAM175A, FANCE, PHC2, RAD50, ANAPC13, CBX2, PCNA, BMI1, BABAM1, UBE2D2, CCNE1, CUL7, BACH1, PCGF2, MSH2, RAD51, ANAPC2, CDC27, PCGF6, CSTF1, FANCF, CBX8, RBBP8, ANAPC5, ANAPC16, CDC23, TOPBP1, CBX4, UBE2C, CDK2, UBE2N, ATR, UBE2D3, ANAPC7, UIMC1, CDC16, FANCC, RBX1, MSH6, PHC1, ANAPC1, ANAPC10, FANCA, RNF2, UBE2S, UBE2D1, FANCL, BUB1B, CBX7, TP53, FANCG, ESR1, UBC, CSTF2, PHC3, XRCC5
BRCA1KRASNo-9ABL1, CCND1, TP53, UBC, JUN, HSP90AA1, AKT1, NPM1, SRC
BRCA1TP53Yesactivation, binding82STAG2, AURKA, TREX1, CDK2, UBE2K, PCNA, NCOA3, TOPORS, RPA1, SMARCB1, MNAT1, CDK4, POLH, ERCC6, CDK1, BMI1, CTBP1, MSH6, SKP2, SP1, TERF2, AR, E2F4, SUMO1, TP73, EP300, CCND1, ABL1, STAT5A, CREB1, CDK8, SRSF1, TFDP1, CCNA2, SMAD3, SUMO3, SIRT1, UBE2I, CDKN1A, CCNB1, SMARCA4, ZNF148, TOPBP1, VDR, UBE2N, HDAC1, RB1, BARD1, ATR, RNF2, HSP90AA1, JUN, TOP2A, RAD51, AKT1, NPM1, RPA3, BRCA2, H2AFX, SUMO2, CHEK2, FHL2, TP53BP1, USP7, MSH2, HSPA8, XRCC5, UBE2D1, CCNA1, CREBBP, HDAC2, UIMC1, PLK1, GADD45A, BLM, HIF1A, ESR1, UBC, MYC, RELA, MLH1, CUL7
BRCA1SLC22A18No-1UBC
BRCA1ESR1Yesbinding44AR, AKT1, TP53, ATF2, PGR, PCNA, SP1, SUMO1, CTBP1, MSH2, NCOA3, POLR2A, STAT5A, SMAD3, AHR, NCOA2, E2F1, SIRT1, UBE2I, CDKN1A, MED17, GTF2E1, VDR, HDAC1, BARD1, COBRA1, HSP90AA1, JUN, LMO4, ABL1, SRC, EP300, MNAT1, SMARCA2, HSPA8, CREBBP, HDAC2, PIK3R1, GTF2F1, SMARCA4, UBC, MYC, RELA, CCND1
BRCA1PHBNo-11SMARCA2, AKT1, HDAC1, BRE, RNF2, RB1, TP53, ESR1, UBC, E2F1, SMARCA4
BRCA1PALB2Yesbinding8FANCI, BRCA2, MORF4L1, RBBP8, RAD51C, BRIP1, FANCD2, RAD51
BRCA1RAD51Yesactivation, binding34BRE, HIST3H3, ABL1, H2AFX, PALB2, ACACA, TP53, TEX15, TP53BP1, RPA3, MSH6, SUMO1, MSH2, RPA1, RPA2, MND1, RAD18, DMC1, BARD1, SMARCA2, CDK4, PCNA, PSMC3IP, SUMO2, UBE2I, MSH3, BRCA2, CDK2, PLK1, BLM, SMARCA4, POLH, MLH1, RAD51C
BRCA1PIK3CANo-14SP1, AR, CTNNB1, CCND1, RELA, CREB1, PIK3R1, SMAD3, TP53, ESR1, SRC, PGR, AKT1, MYC
BRCA2BARD1No-11AURKB, FANCA, CDK2, FANCD2, BUB1B, ATR, TP53, RAD51, BRCA1, H2AFX, FANCG
BRCA2KRASNo-1TP53
BRCA2TP53Yesactivation, binding20AURKB, AR, STAT5A, TREX1, CDK2, CDK4, BCCIP, CHEK1, ATR, RPA1, BLM, SMAD3, PLK1, RPA3, SNAI2, CHEK2, H2AFX, BRCA1, RAD51, MLH1
BRCA2ESR1No-6AR, STAT5A, TP53, SNAI2, SMAD3, BRCA1
BRCA2PHBNo-1TP53
BRCA2PALB2Yesbinding6FANCI, FANCD2, RAD51, BRCA1, BRIP1, RAD51C
BRCA2RAD51Yesactivation, binding24HIST3H3, PALB2, TP53, TEX15, MSH4, XRCC3, RPA3, TOP3A, PSMC3IP, MLH1, RPA1, MCPH1, RPA2, BRCA1, DMC1, CDK4, H2AFX, CDK2, CHEK1, PLK1, BLM, MLH3, MND1, RAD51C
BRCA2PIK3CANo-3AR, SMAD3, TP53
BARD1KRASNo-2UBC, TP53
BARD1TP53Yesactivation, binding22AURKB, XRCC6, EWSR1, BMI1, MSH6, ATR, MSH2, BRCA1, TOPBP1, UBE2N, RNF2, UIMC1, PCNA, H2AFX, CDK2, UBE2D1, AURKA, XRCC5, CUL7, ESR1, UBC, RAD51
BARD1SLC22A18No-1UBC
BARD1ESR1Yesbinding5UBC, BRCA1, MSH2, TP53, PCNA
BARD1PHBNo-5UBC, BRE, ESR1, TP53, RNF2
BARD1PALB2No-4BRCA1, RBBP8, FANCD2, RAD51
BARD1RAD51Yesbinding8MSH6, BRE, CDK2, MSH2, TP53, PCNA, H2AFX, BRCA1
BARD1PIK3CANo-2ESR1, TP53
KRASTP53Yesactivation, binding40BCL2L1, ABL1, MAPK1, PTPN11, ETS2, BTRC, NPM1, EGFR, HBEGF, LGALS3, PRMT1, MAPK11, CTGF, CCND1, PTK2, MDM4, EPHA2, ERBB2, RAF1, MAPK14, MAPK7, NCL, HRAS, PRMT5, NOTCH1, MAPK13, JUN, HSP90AA1, AKT1, VEGFA, MAPK12, ETS1, MGMT, BCL2, MAPK3, MTOR, ERBB4, PIK3CA, UBC, TSG101
KRASSLC22A18No-1UBC
KRASESR1No-26AKT1, MAPK1, TP53, SOS1, EGFR, CTGF, PRMT1, MAPK11, PPARD, PIK3CA, ERBB2, MAPK14, AKT2, HSP90AA1, JUN, NT5E, ABL1, SRC, VEGFA, SHC1, MGMT, MAPK3, IRS1, UBC, GRB2, CCND1
KRASPHBNo-4UBC, RAF1, TP53, AKT1
KRASRAD51No-3IRS1, TP53, ABL1
KRASPIK3CAYesactivation, binding37BCL2L1, EGFR, RET, MAP2K2, TP53, SOS1, PIK3CG, TEK, VEGFA, ANGPT1, MAP2K1, PTK2, EPHA2, ERBB2, ERBB3, RAF1, SHC1, AKT2, KIT, HRAS, RPS6KB1, GRB2, AKT1, SRC, FYN, FRS2, YES1, NOTCH1, PTPN11, PIK3CB, MTOR, IRS2, EGF, IRS1, PIK3CD, CCND1, ERBB4
TP53SLC22A18No-2UBC, RB1CC1
TP53ESR1Yesactivation, binding109POU4F2, ABL1, CAV1, TRIM24, HDAC9, PCNA, FOXO3, MAP3K1, NCOA3, ERBB2, RBBP5, MAPK14, BARD1, JUN, POU4F1, NR4A1, AKT1, PRDM2, EP400, NEDD8, MAPK3, HMGA1, SMARCA4, AR, EGFR, STK11, TWIST1, EZH2, MYB, ASH2L, STUB1, SP1, CARM1, KDM1A, PPARGC1A, TERT, TSC2, GAPDH, NR4A2, HSP90AA1, MAPK11, IGF1R, HDAC2, UBC, MSH2, MTA2, SMAD4, KAT5, FOS, NCOR1, PHB, NOS3, FOXM1, SUMO1, CCND1, KLF5, STAT5A, MTA1, SMAD3, FOXO1, BRCA1, SIRT1, HDAC1, SMAD2, MED1, PTEN, VEGFA, EP300, LEP, MGMT, NR0B2, WDR5, TADA3, MNAT1, HNF4A, MDM2, TBP, MAPK1, XPO1, SNAI2, CXCL12, CTBP1, MUC1, PIK3CA, CDK9, COPS5, CD82, COL18A1, CDKN1A, VDR, SIN3A, CTSD, CTGF, PARP1, PRMT1, MTA3, UBE2I, STAT3, HSPA8, NR3C1, DDX17, CREBBP, HSPA4, PAGR1, IL6, SP3, MYC, RELA, PPARG
TP53PHBYesactivation, binding12RAF1, HDAC1, ANXA2, RNF2, RB1, NCOR1, ESR1, UBC, SMARCA4, AKT1, HIC1, YWHAZ
TP53PALB2No-3BRCA1, BRCA2, RAD51
TP53RAD51Yesactivation, binding29PCNA, FOXM1, CDK4, PLK1, RPA3, H2AFX, RAD9A, EGR1, MSH2, RPA1, BRCA1, CDK2, BARD1, SUMO1, ABL1, MSH6, SUMO2, UBE2I, PMS2, BRCA2, POLI, WRN, CHEK1, TP53BP1, BLM, SMARCA4, POLH, UBE2A, MLH1
TP53PIK3CAYesactivation, expression42BCL2L1, PTEN, MET, EPHB4, LYN, AGT, CREB1, EGFR, SP1, PRKCD, GSK3B, CCND1, PTK2, EPHA2, ERBB2, SMAD3, RAF1, NGFR, YWHAZ, HGF, AR, HRAS, EFNB1, NOTCH1, CDH1, SMAD2, AKT1, NTN1, VEGFA, NFKB1, STAT3, KRAS, NR3C1, PTPN11, BDNF, RELA, MTOR, SGK1, ESR1, MYC, IGF1R, ERBB4
SLC22A18ESR1No-1UBC
SLC22A18PHBNo-1UBC
ESR1PHBYesbinding8SMARCA2, SMARCA4, HDAC1, TP53, AKT1, UBC, E2F1, NCOR1
ESR1PALB2No-1BRCA1
ESR1RAD51No-13SMARCA2, FOXM1, SUMO1, MSH2, BARD1, TP53, CEBPB, ABL1, IRS1, PCNA, BRCA1, UBE2I, SMARCA4
ESR1PIK3CAYesactivation, binding44AR, PELP1, PGR, GNG2, GNA11, GNA15, TP53, CCND3, SOS1, EGFR, GNAI1, SP1, INS, RHOA, THRB, ERBB2, SMAD3, SGK3, SHC1, GNB1, AKT2, THRA, RPS6KA3, GNA14, SMAD2, AKT1, SRC, VEGFA, GRB2, STAT3, NR3C1, IGF1R, RRAS2, IRS1, GNAI3, PIK3R1, PTEN, RAC3, IGF1, GNAQ, MYC, RELA, CCND1, BCAR1
PHBRAD51No-4SMARCA2, TP53, SMARCA4, BRE
PHBPIK3CANo-5TP53, RAF1, ESR1, AKT1, YWHAZ
PALB2RAD51Yesbinding3BRCA1, BRCA2, RAD51C
RAD51PIK3CANo-3BCR, IRS1, TP53

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
ATMBRIP1No-1BRCA1
ATMFAM175ANo-1BRCA1
ATMNBNYesMDC1-MRN-ATM-FANCD2 complex;ATM-NBS1 complex;BASC complex (BRCA1-associated genome surveillance complex)13ATM, FANCD2, RFC2, MSH2, MSH6, MDC1, BLM, MRE11A, RFC1, RFC4, RAD50, BRCA1, MLH1
ATMBRCA1YesBASC (Ab 81) complex (BRCA1-associated genome surveillance complex);BASC complex (BRCA1-associated genome surveillance complex)11ATM, NBN, MSH2, MRE11A, MSH6, RFC1, BLM, RAD50, RFC4, RFC2, MLH1
ATMBRCA2No-1BRCA1
ATMBARD1No-6NBN, MRE11A, RAD50, MSH6, BRCA1, MLH1
ATMTP53No-3MSH6, BLM, MSH2
ATMRAD51No-4MSH6, BRCA1, MSH2, BLM
BRIP1FAM175ANo-1BRCA1
BRIP1NBNNo-1BRCA1
BRIP1BRCA1YesBRCA1-BACH1 complex0
BRIP1BRCA2No-1BRCA1
BRIP1BARD1No-1BRCA1
BRIP1RAD51No-1BRCA1
XRCC3RAD51No-1XRCC2
FAM175ANBNNo-2BRCA1, BARD1
FAM175ABRCA1YesBRCA1 A complex2UIMC1, BARD1
FAM175ABRCA2No-2BRCA1, BARD1
FAM175ABARD1YesBRCA1 A complex2BRCA1, UIMC1
FAM175ATP53No-1BARD1
FAM175ARAD51No-1BRCA1
NBNBRCA1YesBRCA1-BARD1-BACH1-DNA damage complex II;BRCA1-RAD50-MRE11-NBS1 complex;BASC complex (BRCA1-associated genome surveillance complex)15ATM, TOPBP1, RFC2, BACH1, MLH1, BARD1, TRRAP, RFC1, MRE11A, BLM, RBBP8, RFC4, RAD50, MSH6, MSH2
NBNBRCA2No-2BRCA1, BARD1
NBNBARD1YesBRCA1-BARD1-BACH1-DNA damage complex II9TOPBP1, BACH1, MRE11A, XRCC6, RBBP8, RAD50, MSH6, BRCA1, MLH1
NBNTP53No-5MSH6, BARD1, BLM, XRCC6, MSH2
NBNESR1No-1TRRAP
NBNRAD51No-4MSH6, BRCA1, MSH2, BLM
CDH1BRCA1No-1SMAD3
CDH1ESR1No-2SRC, BCAR1
BRCA1BRCA2YesBRCC complex;BRCA1-BARD1-BRCA2-DNA damage complex III6BRE, HDAC2, HDAC1, BARD1, BRCC3, RAD51
BRCA1BARD1YesBARD1-BRCA1-CSTF64 complex;BRCA1-BARD1-UbcH7c complex;HUIC complex;BRCA1-BARD1-POLR2A complex;BARD1-BRCA1-CSTF complex;BRCA1-BARD1-BRCA2-DNA damage complex III;BRCA1 B complex;BRCA1-BARD1-BACH1-DNA damage complex II;BRCA1 C complex;BRCA1-BARD1-UbcH5c complex;BRCA1-BARD1-BACH1-DNA damage complex I;BRCA1 A complex17NBN, TOPBP1, BRCA2, BACH1, MRE11A, UIMC1, UBE2L3, CSTF3, FAM175A, POLR2A, RBBP8, UBE2D3, RAD50, CSTF2, MSH6, MLH1, CSTF1
BRCA1TP53No-5MSH6, BLM, BARD1, MSH2, RAD51
BRCA1ESR1No-3TRRAP, HDAC2, KAT2A
BRCA1RAD51YesBRCC complex;BRCA1-RAD51 complex6BRE, BRCA2, MSH2, BLM, MSH6, BRCC3
BRCA2BARD1YesBRCA1-BARD1-BRCA2-DNA damage complex III1BRCA1
BRCA2TP53No-2BARD1, RAD51
BRCA2ESR1No-1HDAC2
BRCA2RAD51YesBRCC complex3BRCA1, BRE, BRCC3
BARD1TP53YesP53-BARD1-Ku70 complex3MSH6, XRCC6, TP53
BARD1ESR1No-1TP53
BARD1RAD51No-4BRCA1, BRCA2, MSH6, TP53
TP53ESR1YesEr-alpha-p53-hdm2 complex3SP1, TP53, MDM2
TP53RAD51YesMSH2/6-BLM-p53-RAD51 complex4MSH6, BLM, MSH2, TP53
ESR1CASP8No-1CHUK
ESR1RAD51No-1TP53
ESR1PIK3CANo-1PIK3R1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
BRIP1FAM175ANo1BRCA1
BRIP1BRCA1Yes2BRCA1, BRIP1
BRIP1BARD1No1BRCA1
FAM175ABRCA1Yes2FAM175A, BRCA1
FAM175ABARD1No1BRCA1
BRCA1BARD1Yes2BRCA1, BARD1
BRCA2PALB2Yes2PALB2, BRCA2
BRCA2RAD51Yes2BRCA2, RAD51
PALB2RAD51No1BRCA2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
CHEK2TP53yes, they interactTP53 is phosphorylated on Ser-20 by CHEK2 in response to DNA damage. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Pathways in cancerhsa052003.988KRAS, BRCA2, CASP8, PIK3CA, CDH1, TP53, AKT1, RAD51
Pancreatic cancerhsa052126.566BRCA2, TP53, KRAS, PIK3CA, AKT1, RAD51
HTLV-I infectionhsa051664.596ATM, TP53, KRAS, PIK3CA, AKT1, CHEK2
Melanomahsa052186.565TP53, KRAS, AKT1, PIK3CA, CDH1
Fanconi anemia pathwayhsa034607.015BRCA2, BRCA1, BRIP1, PALB2, RAD51
Proteoglycans in cancerhsa052055.025TP53, ESR1, KRAS, AKT1, PIK3CA
Endometrial cancerhsa052136.815TP53, KRAS, AKT1, CDH1, PIK3CA
MicroRNAs in cancerhsa052065.385ATM, BRCA1, KRAS, TP53, PIK3CA
p53 signaling pathwayhsa041156.565ATM, CHEK2, PPM1D, CASP8, TP53
Homologous recombinationhsa034407.915NBN, RAD54L, BRCA2, RAD51, XRCC3
Apoptosishsa042106.235ATM, CASP8, TP53, AKT1, PIK3CA
Thyroid hormone signaling pathwayhsa049195.825TP53, KRAS, ESR1, AKT1, PIK3CA
Hepatitis Bhsa051615.525KRAS, CASP8, TP53, AKT1, PIK3CA
PI3K-Akt signaling pathwayhsa041514.215TP53, BRCA1, KRAS, AKT1, PIK3CA
Colorectal cancerhsa052106.524KRAS, TP53, AKT1, PIK3CA
Estrogen signaling pathwayhsa049156.114ESR1, KRAS, AKT1, PIK3CA
Gliomahsa052146.664TP53, AKT1, KRAS, PIK3CA
Prostate cancerhsa052156.114KRAS, TP53, AKT1, PIK3CA
Rap1 signaling pathwayhsa040154.974KRAS, AKT1, PIK3CA, CDH1
Neurotrophin signaling pathwayhsa047225.784KRAS, TP53, AKT1, PIK3CA
Central carbon metabolism in cancerhsa052306.74TP53, KRAS, AKT1, PIK3CA
Viral carcinogenesishsa052035.084KRAS, CASP8, TP53, PIK3CA
FoxO signaling pathwayhsa040685.634ATM, AKT1, KRAS, PIK3CA
Chronic myeloid leukemiahsa052206.484TP53, KRAS, AKT1, PIK3CA
Non-small cell lung cancerhsa052236.884TP53, AKT1, KRAS, PIK3CA
Hepatitis Chsa051605.684TP53, KRAS, AKT1, PIK3CA
Prolactin signaling pathwayhsa049176.64KRAS, ESR1, AKT1, PIK3CA
Signaling pathways regulating pluripotency of stem cellshsa045505.63AKT1, KRAS, PIK3CA
Bladder cancerhsa052197.383KRAS, TP53, CDH1
Progesterone-mediated oocyte maturationhsa049146.183AKT1, KRAS, PIK3CA
Renal cell carcinomahsa052116.63AKT1, KRAS, PIK3CA
Thyroid cancerhsa052167.483KRAS, TP53, CDH1
Cholinergic synapsehsa047255.883KRAS, AKT1, PIK3CA
Choline metabolism in cancerhsa052316.093KRAS, AKT1, PIK3CA
Chemokine signaling pathwayhsa040625.193KRAS, AKT1, PIK3CA
Chagas disease (American trypanosomiasis)hsa051425.993AKT1, CASP8, PIK3CA
Epstein-Barr virus infectionhsa051694.973AKT1, TP53, PIK3CA
Toxoplasmosishsa051455.713CASP8, AKT1, PIK3CA
Measleshsa051625.63TP53, AKT1, PIK3CA
VEGF signaling pathwayhsa043706.773KRAS, AKT1, PIK3CA
Cell cyclehsa041105.683ATM, CHEK2, TP53
Toll-like receptor signaling pathwayhsa046206.03CASP8, AKT1, PIK3CA
T cell receptor signaling pathwayhsa046606.013KRAS, AKT1, PIK3CA
Insulin signaling pathwayhsa049105.553KRAS, PIK3CA, AKT1
Ras signaling pathwayhsa040144.93KRAS, PIK3CA, AKT1
Fc epsilon RI signaling pathwayhsa046646.63KRAS, AKT1, PIK3CA
Small cell lung cancerhsa052226.173TP53, AKT1, PIK3CA
Acute myeloid leukemiahsa052216.743KRAS, PIK3CA, AKT1
MAPK signaling pathwayhsa040104.633KRAS, TP53, AKT1
TNF signaling pathwayhsa046685.963CASP8, AKT1, PIK3CA
Non-alcoholic fatty liver disease (NAFLD)hsa049325.513CASP8, AKT1, PIK3CA
B cell receptor signaling pathwayhsa046626.523AKT1, KRAS, PIK3CA
ErbB signaling pathwayhsa040126.153KRAS, PIK3CA, AKT1
Platelet activationhsa046115.662PIK3CA, AKT1
cGMP-PKG signaling pathwayhsa040225.322AKT1, PIK3CA
Natural killer cell mediated cytotoxicityhsa046505.532KRAS, PIK3CA
cAMP signaling pathwayhsa040245.052PIK3CA, AKT1
Jak-STAT signaling pathwayhsa046305.442AKT1, PIK3CA
Tight junctionhsa045305.532KRAS, AKT1
Focal adhesionhsa045104.922PIK3CA, AKT1
Osteoclast differentiationhsa043805.642PIK3CA, AKT1
HIF-1 signaling pathwayhsa040665.92AKT1, PIK3CA
Oxytocin signaling pathwayhsa049215.42KRAS, PIK3CA
Aldosterone-regulated sodium reabsorptionhsa049607.412KRAS, PIK3CA
Herpes simplex infectionhsa051685.082CASP8, TP53
Influenza Ahsa051645.212AKT1, PIK3CA
Bacterial invasion of epithelial cellshsa051006.342PIK3CA, CDH1
Transcriptional misregulation in cancerhsa052025.212ATM, TP53
Fc gamma R-mediated phagocytosishsa046666.212PIK3CA, AKT1
AMPK signaling pathwayhsa041525.82AKT1, PIK3CA
mTOR signaling pathwayhsa041506.722AKT1, PIK3CA
Regulation of actin cytoskeletonhsa048104.92KRAS, PIK3CA
Carbohydrate digestion and absorptionhsa049737.282PIK3CA, AKT1
Tuberculosishsa051525.172CASP8, AKT1
Huntington's diseasehsa050165.172CASP8, TP53
Adrenergic signaling in cardiomyocyteshsa042615.442AKT1, PIK3CA

NET-GE enrichment

Term New enriched termICP valueGenes
Salmonella infection (hsa05132) NEW6.290.002ESR1, CASP8, CDH1, TP53, AKT1, PIK3CA
Melanoma (hsa05218) -6.560.0ESR1, TP53, CDH1, KRAS, AKT1, PIK3CA
Bladder cancer (hsa05219) -7.380.003TP53, KRAS, AKT1, CDH1
Progesterone-mediated oocyte maturation (hsa04914) -6.180.0KRAS, ESR1, CDH1, TP53, AKT1, PIK3CA, BRCA1
Pancreatic cancer (hsa05212) -6.560.0KRAS, BRCA2, ESR1, TP53, PIK3CA, AKT1, RAD51
Natural killer cell mediated cytotoxicity (hsa04650) -5.530.009ESR1, CASP8, KRAS, TP53, AKT1, PIK3CA
Colorectal cancer (hsa05210) -6.520.002TP53, KRAS, ESR1, AKT1, PIK3CA
Estrogen signaling pathway (hsa04915) -6.110.024ATM, ESR1, KRAS, AKT1, PIK3CA
Thyroid cancer (hsa05216) -7.480.002TP53, ESR1, KRAS, CDH1
Signaling pathways regulating pluripotency of stem cells (hsa04550) -5.60.0KRAS, ESR1, CDH1, TP53, AKT1, PIK3CA, BRCA1, CHEK2
Glioma (hsa05214) -6.660.005TP53, KRAS, ESR1, AKT1, PIK3CA
Prostate cancer (hsa05215) -6.110.011TP53, KRAS, ESR1, AKT1, PIK3CA
Lipid metabolismNEW4.160.036ATM, KRAS, AKT1, CASP8, BARD1, TP53, PIK3CA, ESR1, BRCA1
Excretory systemNEW5.450.027ATM, ESR1, KRAS, TP53, AKT1, PIK3CA
Central carbon metabolism in cancer (hsa05230) -6.70.001TP53, KRAS, AKT1, PIK3CA, CDH1
Choline metabolism in cancer (hsa05231) -6.090.042ATM, TP53, KRAS, AKT1, PIK3CA
FoxO signaling pathway (hsa04068) -5.630.0ATM, KRAS, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1
Chemokine signaling pathway (hsa04062) -5.190.007ATM, KRAS, ESR1, CDH1, TP53, AKT1, PIK3CA
Thyroid hormone signaling pathway (hsa04919) -5.820.003ATM, KRAS, ESR1, TP53, PIK3CA, AKT1, BRCA1
Endometrial cancer (hsa05213) -6.810.0ESR1, TP53, CDH1, KRAS, AKT1, PIK3CA
Inflammatory mediator regulation of TRP channels (hsa04750) NEW6.070.041ATM, ESR1, TP53, AKT1, PIK3CA
Chagas disease (American trypanosomiasis) (hsa05142) -5.990.003ATM, ESR1, CASP8, TP53, PIK3CA, AKT1
Replication and repairNEW5.410.0ATM, NBN, BRCA2, XRCC3, PALB2, TP53, ESR1, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
Amoebiasis (hsa05146) NEW5.820.01ATM, CASP8, CDH1, RB1CC1, PIK3CA, AKT1
Infectious diseases: ParasiticNEW4.460.015ATM, KRAS, ESR1, CASP8, TP53, CDH1, RB1CC1, PIK3CA, AKT1
Toxoplasmosis (hsa05145) -5.710.01ESR1, CASP8, KRAS, TP53, AKT1, PIK3CA
Herpes simplex infection (hsa05168) -5.080.0ATM, KRAS, ESR1, CASP8, PPM1D, TP53, CDH1, AKT1, CHEK2
HTLV-I infection (hsa05166) -4.590.016ATM, KRAS, BRCA2, AKT1, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2
Hepatitis C (hsa05160) -5.680.001KRAS, ESR1, PPM1D, CDH1, TP53, AKT1, PIK3CA
Hepatitis B (hsa05161) -5.520.008KRAS, ESR1, CASP8, CDH1, TP53, AKT1, PIK3CA
Measles (hsa05162) -5.60.001ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1, BRCA1
Apoptosis (hsa04210) -6.230.001ATM, CASP8, TP53, AKT1, PIK3CA
Cancers: OverviewNEW2.720.002ATM, NBN, KRAS, BRCA2, AKT1, CASP8, PPM1D, BARD1, TP53, PHB, CDH1, PIK3CA, ESR1, BRCA1, BRIP1, CHEK2, RAD51
Cancers: Specific typesNEW4.10.013NBN, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, RAD51
Proteoglycans in cancer (hsa05205) -5.020.04KRAS, ESR1, CDH1, TP53, AKT1, PIK3CA, BRCA1
Cell cycle (hsa04110) -5.680.0ATM, BARD1, CDH1, TP53, ESR1, BRCA1, CHEK2
MicroRNAs in cancer (hsa05206) -5.380.013ATM, KRAS, ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1
Toll-like receptor signaling pathway (hsa04620) -6.00.029CASP8, ESR1, TP53, AKT1, PIK3CA
Pathways in cancer (hsa05200) -3.980.002ATM, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, RAD51
Oocyte meiosis (hsa04114) NEW5.910.002ATM, ESR1, PPM1D, TP53, AKT1, BRCA1
p53 signaling pathway (hsa04115) -6.560.0ATM, CASP8, PPM1D, TP53, CHEK2, BRCA1
T cell receptor signaling pathway (hsa04660) -6.010.031KRAS, CASP8, AKT1, ESR1, PIK3CA
Homologous recombination (hsa03440) -7.910.0NBN, BRCA2, XRCC3, CHEK2, RAD54L, RAD51
Insulin signaling pathway (hsa04910) -5.550.028ESR1, KRAS, TP53, AKT1, PIK3CA, BRCA1
Transport and catabolismNEW3.490.016ATM, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, CHEK2, TSG101
Non-small cell lung cancer (hsa05223) -6.880.002AKT1, TP53, ESR1, KRAS, PIK3CA
Prolactin signaling pathway (hsa04917) -6.60.005TP53, KRAS, ESR1, AKT1, PIK3CA
Acute myeloid leukemia (hsa05221) -6.740.027KRAS, ESR1, AKT1, PIK3CA
Chronic myeloid leukemia (hsa05220) -6.480.0ESR1, TP53, CDH1, KRAS, AKT1, PIK3CA
Viral carcinogenesis (hsa05203) -5.080.0ATM, PHB, KRAS, AKT1, CASP8, TP53, PIK3CA, ESR1, BRCA1
Fanconi anemia pathway (hsa03460) -7.010.0BRCA2, PALB2, BRCA1, BRIP1, CHEK2, RAD51
Type II diabetes mellitus (hsa04930) NEW7.120.018ESR1, TP53, AKT1, PIK3CA
Cell growth and deathNEW4.410.0ATM, AKT1, CASP8, PPM1D, BARD1, PIK3CA, CDH1, TP53, ESR1, BRCA1, CHEK2
Genetic Information ProcessingNEW2.480.0ATM, NBN, XRCC3, BRCA2, AKT1, PPM1D, PALB2, BARD1, TP53, PHB, CDH1, RB1CC1, PIK3CA, ESR1, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
MAPK signaling pathway (hsa04010) -4.630.016ATM, KRAS, ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1
NOD-like receptor signaling pathway (hsa04621) NEW6.880.041TP53, CASP8, AKT1, TSG101
Alcoholism (hsa05034) NEW5.590.02ATM, NBN, ESR1, KRAS, PIK3CA, AKT1
Tuberculosis (hsa05152) -5.170.024KRAS, ESR1, CASP8, TP53, PIK3CA, AKT1, CHEK2
Fc epsilon RI signaling pathway (hsa04664) -6.60.036TP53, KRAS, AKT1, PIK3CA
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Cell CycleR-HSA-16401703.899ATM, NBN, BRCA2, BARD1, TP53, FAM175A, BRCA1, CHEK2, RAD51
Signal TransductionR-HSA-1625821.788PHB, KRAS, ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1
Cell Cycle CheckpointsR-HSA-696205.647ATM, NBN, BARD1, TP53, FAM175A, BRCA1, CHEK2
DNA RepairR-HSA-738945.87ATM, NBN, BRCA2, PALB2, BRCA1, BRIP1, RAD51
G2/M CheckpointsR-HSA-694816.466ATM, NBN, BARD1, FAM175A, BRCA1, CHEK2
Homologous recombination repair of replication-independent double-strand breaksR-HSA-739518.986ATM, NBN, BRCA2, BRCA1, BRIP1, RAD51
G2/M DNA damage checkpointR-HSA-694737.156ATM, NBN, BARD1, FAM175A, BRCA1, CHEK2
Immune SystemR-HSA-1682562.376PHB, CASP8, KRAS, CDH1, AKT1, PIK3CA
Homologous Recombination RepairR-HSA-738888.986ATM, NBN, BRCA2, BRCA1, BRIP1, RAD51
Double-Strand Break RepairR-HSA-738908.466ATM, NBN, BRCA2, BRCA1, BRIP1, RAD51
MeiosisR-HSA-15006206.595ATM, NBN, BRCA1, BRCA2, RAD51
Innate Immune SystemR-HSA-1682493.175PHB, CASP8, KRAS, AKT1, PIK3CA
Meiotic recombinationR-HSA-9124467.255NBN, ATM, BRCA1, BRCA2, RAD51
Signaling by ERBB4R-HSA-12363944.75PHB, KRAS, AKT1, ESR1, PIK3CA
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.854PHB, KRAS, PIK3CA, AKT1
Programmed Cell DeathR-HSA-53578015.654TP53, CASP8, AKT1, CDH1
IGF1R signaling cascadeR-HSA-24289244.854PHB, AKT1, PIK3CA, KRAS
Downstream signal transductionR-HSA-1867634.654PHB, AKT1, KRAS, PIK3CA
IRS-related events triggered by IGF1RR-HSA-24289284.854PHB, AKT1, KRAS, PIK3CA
Signaling by Insulin receptorR-HSA-747524.734PHB, AKT1, KRAS, PIK3CA
Adaptive Immune SystemR-HSA-12802183.194KRAS, AKT1, PIK3CA, CDH1
DiseaseR-HSA-16436853.334KRAS, AKT1, PIK3CA, TSG101
Insulin receptor signalling cascadeR-HSA-747514.854PHB, KRAS, PIK3CA, AKT1
Downstream signaling of activated FGFR1R-HSA-56546874.714PHB, AKT1, PIK3CA, KRAS
Signalling by NGFR-HSA-1665204.234PHB, AKT1, KRAS, PIK3CA
Signaling by VEGFR-HSA-1941384.664PHB, KRAS, PIK3CA, AKT1
Cellular responses to stressR-HSA-22627524.564ATM, NBN, RB1CC1, TP53
IRS-mediated signallingR-HSA-1123994.874PHB, KRAS, PIK3CA, AKT1
Downstream signaling of activated FGFR3R-HSA-56547084.714PHB, KRAS, AKT1, PIK3CA
Signaling by FGFR4R-HSA-56547434.694PHB, AKT1, KRAS, PIK3CA
Signaling by FGFR3R-HSA-56547414.694PHB, KRAS, AKT1, PIK3CA
VEGFA-VEGFR2 PathwayR-HSA-44200974.74PHB, AKT1, PIK3CA, KRAS
Signaling by FGFRR-HSA-1902364.674PHB, AKT1, KRAS, PIK3CA
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.034PHB, KRAS, PIK3CA, AKT1
Signaling by SCF-KITR-HSA-14335574.734PHB, KRAS, AKT1, PIK3CA
Signaling by PDGFR-HSA-1867974.534PHB, KRAS, AKT1, PIK3CA
DAP12 signalingR-HSA-24244914.644PHB, AKT1, KRAS, PIK3CA
Downstream signaling of activated FGFR2R-HSA-56546964.714PHB, KRAS, PIK3CA, AKT1
Signaling by EGFRR-HSA-1779294.594PHB, KRAS, PIK3CA, AKT1
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.514PHB, KRAS, AKT1, PIK3CA
Fanconi Anemia pathwayR-HSA-4195248.44ATM, BRCA1, BRCA2, PALB2
Signaling by GPCRR-HSA-3727902.684PHB, KRAS, AKT1, PIK3CA
Signaling by FGFR2R-HSA-56547384.684PHB, AKT1, KRAS, PIK3CA
Signaling by FGFR1R-HSA-56547364.694PHB, KRAS, AKT1, PIK3CA
DAP12 interactionsR-HSA-21721274.564PHB, KRAS, AKT1, PIK3CA
Downstream signaling of activated FGFR4R-HSA-56547164.714PHB, AKT1, KRAS, PIK3CA
Signaling by ERBB2R-HSA-12279864.664PHB, KRAS, AKT1, PIK3CA
MetabolismR-HSA-14307282.344AKT1, BRIP1, PIK3CA, HMMR
HemostasisR-HSA-1095823.984TP53, KRAS, AKT1, PIK3CA
ApoptosisR-HSA-1095815.684TP53, CASP8, AKT1, CDH1
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.593AKT1, KRAS, PIK3CA
Diseases of signal transductionR-HSA-56632024.893KRAS, PIK3CA, AKT1
DNA Damage/Telomere Stress Induced SenescenceR-HSA-25595867.153ATM, NBN, TP53
Cellular SenescenceR-HSA-25595835.73ATM, NBN, TP53
Signaling by InterleukinsR-HSA-4491474.713PHB, KRAS, PIK3CA
Generic Transcription PathwayR-HSA-2124363.863ESR1, TP53, AKT1
Gene ExpressionR-HSA-741602.723ESR1, TP53, AKT1
Interleukin receptor SHC signalingR-HSA-9125265.093PHB, KRAS, PIK3CA
Interleukin-2 signalingR-HSA-4519275.053PHB, KRAS, PIK3CA
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.623KRAS, AKT1, PIK3CA
ATM mediated response to DNA double-strand breakR-HSA-8354210.663ATM, NBN, BRCA1
G1/S DNA Damage CheckpointsR-HSA-696157.083ATM, CHEK2, TP53
Cytokine Signaling in Immune systemR-HSA-12802153.743PHB, KRAS, PIK3CA
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.993PHB, KRAS, PIK3CA
Recruitment of repair and signaling proteins to double-strand breaksR-HSA-751549.983ATM, NBN, BRCA1
ATM mediated phosphorylation of repair proteinsR-HSA-7514810.663ATM, NBN, BRCA1
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.263PHB, KRAS, PIK3CA
Intrinsic Pathway for ApoptosisR-HSA-1096067.733CASP8, TP53, AKT1
Homologous DNA Pairing and Strand ExchangeR-HSA-7601010.183BRCA2, BRIP1, RAD51
Developmental BiologyR-HSA-12667383.483PHB, KRAS, AKT1
PI-3K cascade:FGFR4R-HSA-56547206.372PIK3CA, AKT1
Transcriptional Regulation by TP53R-HSA-37009896.732TP53, AKT1
FCERI mediated MAPK activationR-HSA-28717964.322PHB, KRAS
NCAM signaling for neurite out-growthR-HSA-3751654.92PHB, KRAS
PI3K/AKT activationR-HSA-1982036.322AKT1, PIK3CA
Signaling by FGFR3 in diseaseR-HSA-56553328.522KRAS, PIK3CA
GPVI-mediated activation cascadeR-HSA-1146047.182AKT1, PIK3CA
Signaling by LeptinR-HSA-25865525.12PHB, KRAS
Frs2-mediated activationR-HSA-1709685.122PHB, KRAS
PI3K events in ERBB2 signalingR-HSA-19636426.372PIK3CA, AKT1
Cell surface interactions at the vascular wallR-HSA-2027336.322KRAS, PIK3CA
Cell-Cell communicationR-HSA-15009315.872PIK3CA, CDH1
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.952AKT1, PIK3CA
GAB1 signalosomeR-HSA-1802926.312AKT1, PIK3CA
FRS-mediated FGFR1 signalingR-HSA-56546935.142PHB, KRAS
RAF activationR-HSA-56730008.342PHB, KRAS
RAF/MAP kinase cascadeR-HSA-56730015.152PHB, KRAS
Signaling by Ligand-Responsive EGFR Variants in CancerR-HSA-56378158.732KRAS, PIK3CA
Ubiquitin Mediated Degradation of Phosphorylated Cdc25AR-HSA-696017.282ATM, CHEK2
MAPK family signaling cascadesR-HSA-56830574.892PHB, KRAS
PIP3 activates AKT signalingR-HSA-12576046.372AKT1, PIK3CA
PI3K CascadeR-HSA-1097046.682AKT1, PIK3CA
Apoptotic cleavage of cellular proteinsR-HSA-1114657.732CASP8, CDH1
MAPK1/MAPK3 signalingR-HSA-56849965.112PHB, KRAS
PI-3K cascade:FGFR1R-HSA-56546896.372PIK3CA, AKT1
Presynaptic phase of homologous DNA pairing and strand exchangeR-HSA-7600310.42BRCA2, RAD51
SHC1 events in EGFR signalingR-HSA-1803365.152PHB, KRAS
p53-Dependent G1 DNA Damage ResponseR-HSA-695637.152ATM, TP53
FRS-mediated FGFR2 signalingR-HSA-56547005.142PHB, KRAS
SOS-mediated signallingR-HSA-1124125.152PHB, KRAS
FRS-mediated FGFR3 signalingR-HSA-56547065.142PHB, KRAS
Constitutive Signaling by EGFRvIIIR-HSA-56378109.082KRAS, PIK3CA
CD28 co-stimulationR-HSA-3893567.982PIK3CA, AKT1
Signaling by EGFRvIII in CancerR-HSA-56378129.082KRAS, PIK3CA
p53-Dependent G1/S DNA damage checkpointR-HSA-695807.152ATM, TP53
Signaling by EGFR in CancerR-HSA-16437138.732KRAS, PIK3CA
Autodegradation of the E3 ubiquitin ligase COP1R-HSA-3494257.312ATM, TP53
Signaling by FGFR in diseaseR-HSA-12260997.492KRAS, PIK3CA
C-type lectin receptors (CLRs)R-HSA-56214816.062KRAS, CASP8
PI3K/AKT Signaling in CancerR-HSA-22195286.562PIK3CA, AKT1
GRB2 events in ERBB2 signalingR-HSA-19636405.152PHB, KRAS
CD28 dependent PI3K/Akt signalingR-HSA-3893578.592AKT1, PIK3CA
Signaling by FGFR1 in diseaseR-HSA-56553027.812KRAS, PIK3CA
Membrane TraffickingR-HSA-1999915.262AKT1, TSG101
Activation of BH3-only proteinsR-HSA-1144528.342TP53, AKT1
Signalling to RASR-HSA-1670445.082PHB, KRAS
GPCR downstream signalingR-HSA-3883963.072PIK3CA, AKT1
PI-3K cascade:FGFR2R-HSA-56546956.372PIK3CA, AKT1
Constitutive Signaling by Ligand-Responsive EGFR Cancer VariantsR-HSA-12363828.732KRAS, PIK3CA
TP53 Regulates Metabolic GenesR-HSA-56288976.732TP53, AKT1
Vesicle-mediated transportR-HSA-56536564.332AKT1, TSG101
Prolonged ERK activation eventsR-HSA-1698935.112PHB, KRAS
Apoptotic execution phaseR-HSA-751537.282CASP8, CDH1
Signalling to ERKsR-HSA-1876875.042PHB, KRAS
Stabilization of p53R-HSA-695417.282ATM, TP53
GRB2 events in EGFR signalingR-HSA-1798125.152PHB, KRAS
SHC1 events in ERBB2 signalingR-HSA-12501965.152PHB, KRAS
PI3K events in ERBB4 signalingR-HSA-12503426.372AKT1, PIK3CA
G beta:gamma signalling through PI3KgammaR-HSA-3924517.42AKT1, PIK3CA
G-protein beta:gamma signallingR-HSA-3977957.312AKT1, PIK3CA
ARMS-mediated activationR-HSA-1709845.122PHB, KRAS
PI-3K cascade:FGFR3R-HSA-56547106.372PIK3CA, AKT1
Signaling by FGFR4 in diseaseR-HSA-56552919.522KRAS, PIK3CA
FRS-mediated FGFR4 signalingR-HSA-56547125.142PHB, KRAS
Tie2 SignalingR-HSA-2109938.812KRAS, PIK3CA
p53-Independent DNA Damage ResponseR-HSA-696107.282ATM, CHEK2
p53-Independent G1/S DNA damage checkpointR-HSA-696137.282ATM, CHEK2
SHC1 events in ERBB4 signalingR-HSA-12503475.152PHB, KRAS
Signalling to p38 via RIT and RINR-HSA-1877065.122PHB, KRAS
Axon guidanceR-HSA-4224753.932PHB, KRAS
VEGFR2 mediated cell proliferationR-HSA-52189215.072PHB, KRAS
Signaling by FGFR2 in diseaseR-HSA-56552538.232KRAS, PIK3CA
Platelet activation, signaling and aggregationR-HSA-760025.152PIK3CA, AKT1
Costimulation by the CD28 familyR-HSA-3888416.562PIK3CA, AKT1

NET-GE enrichment

Term New enriched termICP valueGenes
Signaling by FGFR3 in disease (R-HSA-5655332) -8.520.018KRAS, PIK3CA, CDH1
Cellular responses to stress (R-HSA-2262752) -4.560.023ATM, NBN, CASP8, TP53, RB1CC1, CDH1, AKT1, BRCA1, CHEK2
Recruitment of repair and signaling proteins to double-strand breaks (R-HSA-75154) -9.980.0ATM, NBN, BRCA1
Cell Cycle (R-HSA-1640170) -3.890.0ATM, NBN, BRCA2, AKT1, PPM1D, BARD1, TP53, FAM175A, ESR1, BRCA1, CHEK2, RAD51
Homologous recombination repair of replication-independent double-strand breaks (R-HSA-73951) -8.980.0ATM, NBN, BRCA2, BRCA1, BRIP1, RAD51
RAF activation (R-HSA-5673000) -8.340.04PHB, KRAS, AKT1
G2/M DNA damage checkpoint (R-HSA-69473) -7.150.0ATM, NBN, BARD1, FAM175A, BRCA1, CHEK2
Presynaptic phase of homologous DNA pairing and strand exchange (R-HSA-76003) -10.40.03BRCA2, RAD51
Phospholipid metabolism (R-HSA-1483257) NEW5.830.002ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1, BRCA1
ATM mediated response to DNA double-strand break (R-HSA-83542) -10.660.0ATM, NBN, BRCA1
Cell Cycle Checkpoints (R-HSA-69620) -5.640.0ATM, NBN, BARD1, TP53, FAM175A, BRCA1, CHEK2, RAD51
Homologous Recombination Repair (R-HSA-73888) -8.980.0ATM, NBN, BRCA2, BRCA1, BRIP1, RAD51
FGFR1 mutant receptor activation (R-HSA-1839124) NEW8.120.005ESR1, AKT1, PIK3CA, CDH1
Signaling by FGFR in disease (R-HSA-1226099) -7.490.001AKT1, KRAS, ESR1, PIK3CA, CDH1
MAP kinase activation in TLR cascade (R-HSA-450294) NEW7.280.022ATM, CASP8, TP53, AKT1
Signaling by FGFR1 in disease (R-HSA-5655302) -7.810.0KRAS, ESR1, AKT1, CDH1, PIK3CA
NCAM signaling for neurite out-growth (R-HSA-375165) -4.90.031PHB, KRAS, ESR1, CDH1, RB1CC1, TP53, AKT1, PIK3CA
ATM mediated phosphorylation of repair proteins (R-HSA-75148) -10.660.0ATM, NBN, BRCA1
Fanconi Anemia pathway (R-HSA-419524) -8.40.0ATM, BRCA1, BRCA2, PALB2
G2/M Checkpoints (R-HSA-69481) -6.460.0ATM, NBN, BARD1, TP53, FAM175A, BRCA1, CHEK2
RHO GTPase Effectors (R-HSA-195258) NEW4.940.003KRAS, ESR1, PPM1D, RAD51, TP53, CDH1, PIK3CA, AKT1, TSG101
Signaling by FGFR2 in disease (R-HSA-5655253) -8.230.034KRAS, PIK3CA, CDH1
Homologous DNA Pairing and Strand Exchange (R-HSA-76010) -10.180.0BRCA2, BRIP1, RAD51
Meiotic recombination (R-HSA-912446) -7.250.0ATM, NBN, BRCA2, TP53, BRCA1, RAD51
Meiosis (R-HSA-1500620) -6.590.001ATM, NBN, BRCA2, TP53, BRCA1, RAD51
DNA Repair (R-HSA-73894) -5.80.0ATM, NBN, BRCA2, PALB2, TP53, ESR1, BRCA1, BRIP1, RAD51
Intrinsic Pathway for Apoptosis (R-HSA-109606) -7.730.039CASP8, TP53, AKT1
Double-Strand Break Repair (R-HSA-73890) -8.460.0ATM, NBN, BRCA2, BRCA1, BRIP1, RAD51
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.1826ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, SLC22A18, BARD1, CDH1, AKT1, BRIP1, HMMR, BRCA2, NQO2, RAD51, ESR1, CHEK2, TSG101
protein binding (GO:0005515) 0.4626ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, SLC22A18, BARD1, CDH1, AKT1, BRIP1, HMMR, BRCA2, NQO2, RAD51, ESR1, CHEK2, TSG101
organic cyclic compound binding (GO:0097159) 1.0518PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, PALB2, BARD1, TP53, RAD51, ESR1, PIK3CA, NBN, CHEK2, RAD54L, BRIP1, BRCA1, TSG101
heterocyclic compound binding (GO:1901363) 1.0618ATM, PHB, XRCC3, KRAS, BRCA2, AKT1, PALB2, BARD1, TP53, RAD51, ESR1, PIK3CA, NBN, CHEK2, RAD54L, BRIP1, BRCA1, TSG101
catalytic activity (GO:0003824) 1.0516ATM, NBN, KRAS, BRCA2, XRCC3, CASP8, PPM1D, BARD1, PIK3CA, NQO2, AKT1, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
enzyme binding (GO:0019899) 2.2714PHB, SLC22A18, BRCA2, AKT1, CASP8, BARD1, PPM1D, TP53, RB1CC1, RAD51, ESR1, BRCA1, CHEK2, TSG101
nucleic acid binding (GO:0003676) 1.4414PHB, ATM, BRCA2, ESR1, PALB2, BARD1, TP53, RAD51, XRCC3, NBN, BRCA1, BRIP1, RAD54L, TSG101
DNA binding (GO:0003677) 1.9213PHB, ATM, BRCA2, XRCC3, PALB2, TP53, RAD51, ESR1, NBN, RAD54L, BRIP1, BRCA1, TSG101
carbohydrate derivative binding (GO:0097367) 2.0312ATM, KRAS, XRCC3, RAD51, TP53, CDH1, PIK3CA, AKT1, RAD54L, BRIP1, CHEK2, HMMR
ion binding (GO:0043167) 1.3611KRAS, AKT1, PPM1D, BARD1, TP53, CDH1, NQO2, ESR1, BRCA1, BRIP1, CHEK2
cation binding (GO:0043169) 1.410KRAS, PPM1D, BARD1, TP53, CDH1, NQO2, ESR1, BRCA1, BRIP1, CHEK2
purine ribonucleoside triphosphate binding (GO:0035639) 2.2210ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
nucleotide binding (GO:0000166) 1.9610ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
small molecule binding (GO:0036094) 1.8910ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
ribonucleotide binding (GO:0032553) 2.1910ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
purine nucleoside binding (GO:0001883) 2.2210ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
ribonucleoside binding (GO:0032549) 2.2210ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
purine ribonucleotide binding (GO:0032555) 2.210ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
purine nucleotide binding (GO:0017076) 2.1910ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
metal ion binding (GO:0046872) 1.4110KRAS, PPM1D, BARD1, TP53, CDH1, NQO2, ESR1, BRCA1, BRIP1, CHEK2
purine ribonucleoside binding (GO:0032550) 2.2210ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
nucleoside phosphate binding (GO:1901265) 1.9610ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
nucleoside binding (GO:0001882) 2.2110ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
adenyl ribonucleotide binding (GO:0032559) 2.419ATM, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
ATP binding (GO:0005524) 2.439ATM, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
adenyl nucleotide binding (GO:0030554) 2.49ATM, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
hydrolase activity (GO:0016787) 1.98NBN, CASP8, PPM1D, KRAS, XRCC3, RAD54L, BRIP1, RAD51
identical protein binding (GO:0042802) 2.638ESR1, CASP8, BARD1, TP53, RAD51, AKT1, CHEK2, TSG101
transferase activity (GO:0016740) 1.957ATM, BRCA2, BARD1, PIK3CA, AKT1, BRCA1, CHEK2
macromolecular complex binding (GO:0044877) 2.617ATM, CASP8, TP53, KRAS, ESR1, BRCA1, RAD51
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 3.036NBN, KRAS, XRCC3, RAD54L, BRIP1, RAD51
ubiquitin protein ligase binding (GO:0031625) 4.176SLC22A18, CASP8, TP53, CHEK2, BRCA1, TSG101
ubiquitin-like protein ligase binding (GO:0044389) 4.156SLC22A18, CASP8, TP53, CHEK2, BRCA1, TSG101
pyrophosphatase activity (GO:0016462) 3.046NBN, KRAS, XRCC3, RAD54L, BRIP1, RAD51
hydrolase activity, acting on acid anhydrides (GO:0016817) 3.036NBN, KRAS, XRCC3, RAD54L, BRIP1, RAD51
nucleoside-triphosphatase activity (GO:0017111) 3.096NBN, KRAS, XRCC3, RAD54L, BRIP1, RAD51
kinase binding (GO:0019900) 3.326PPM1D, BARD1, TP53, RB1CC1, AKT1, CHEK2
protein kinase binding (GO:0019901) 3.445TP53, RB1CC1, PPM1D, CHEK2, AKT1
receptor binding (GO:0005102) 2.435PHB, BRCA1, ESR1, CASP8, TP53
protein dimerization activity (GO:0046983) 2.725ATM, CHEK2, BARD1, TP53, TSG101
transcription regulatory region DNA binding (GO:0044212) 3.034PHB, BRCA1, ESR1, TP53
chromatin binding (GO:0003682) 3.644BRCA1, ESR1, RAD51, TP53
transition metal ion binding (GO:0046914) 2.484BRCA1, BARD1, ESR1, TP53
ATPase activity, coupled (GO:0042623) 3.974NBN, BRIP1, RAD51, XRCC3
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.084ATM, CHEK2, PIK3CA, AKT1
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.774ATM, CHEK2, PIK3CA, AKT1
kinase activity (GO:0016301) 2.934ATM, CHEK2, PIK3CA, AKT1
regulatory region nucleic acid binding (GO:0001067) 3.034PHB, BRCA1, ESR1, TP53
protein serine/threonine kinase activity (GO:0004674) 3.644ATM, CHEK2, PIK3CA, AKT1
zinc ion binding (GO:0008270) 2.664BRCA1, BARD1, ESR1, TP53
ATPase activity (GO:0016887) 3.654NBN, BRIP1, RAD51, XRCC3
regulatory region DNA binding (GO:0000975) 3.034PHB, BRCA1, ESR1, TP53
protein complex binding (GO:0032403) 3.094ATM, KRAS, CASP8, ESR1
protein kinase activity (GO:0004672) 3.274ATM, CHEK2, AKT1, PIK3CA
double-stranded DNA binding (GO:0003690) 3.094ESR1, RAD51, TP53, XRCC3
DNA-dependent ATPase activity (GO:0008094) 5.314NBN, BRIP1, RAD51, XRCC3
enzyme regulator activity (GO:0030234) 2.853AKT1, ESR1, PIK3CA
protein N-terminus binding (GO:0047485) 5.113ATM, NBN, TP53
cytoskeletal protein binding (GO:0008092) 3.023BRCA1, BRCA2, CDH1
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.653PHB, ESR1, TP53
transcription factor binding (GO:0008134) 3.463NBN, ESR1, TP53
damaged DNA binding (GO:0003684) 5.583NBN, BRCA1, TP53
hydrolase activity, acting on ester bonds (GO:0016788) 3.13PPM1D, RAD51, XRCC3
helicase activity (GO:0004386) 4.693NBN, RAD54L, BRIP1
nucleic acid binding transcription factor activity (GO:0001071) 2.653PHB, ESR1, TP53
molecular function regulator (GO:0098772) 2.513ESR1, PIK3CA, AKT1
single-stranded DNA binding (GO:0003697) 5.173BRCA2, RAD51, XRCC3
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.293PHB, ESR1, TP53
protein homodimerization activity (GO:0042803) 3.163CHEK2, BARD1, TSG101
protein C-terminus binding (GO:0008022) 4.52PHB, RAD51
signal transducer activity (GO:0004871) 2.282ESR1, CASP8
ATP-dependent helicase activity (GO:0008026) 5.122NBN, BRIP1
ubiquitin-like protein binding (GO:0032182) 4.932FAM175A, TSG101
GTPase activating protein binding (GO:0032794) 7.12AKT1, CDH1
endodeoxyribonuclease activity (GO:0004520) 5.812RAD51, XRCC3
phosphatidylinositol 3-kinase activity (GO:0035004) 5.492ATM, PIK3CA
DNA helicase activity (GO:0003678) 5.732NBN, BRIP1
G-protein coupled receptor binding (GO:0001664) 4.182PHB, ESR1
ubiquitin-like protein transferase activity (GO:0019787) 3.692BRCA1, BARD1
sequence-specific DNA binding (GO:0043565) 2.792ESR1, TP53
structure-specific DNA binding (GO:0043566) 4.982RAD51, XRCC3
sequence-specific double-stranded DNA binding (GO:1990837) 3.22ESR1, TP53
ligase activity (GO:0016874) 3.722BRCA1, BARD1
transcription coactivator activity (GO:0003713) 4.042BRCA1, TSG101
transcription cofactor activity (GO:0003712) 3.442BRCA1, TSG101
transcription factor activity, transcription factor binding (GO:0000989) 3.362BRCA1, TSG101
transcription factor activity, protein binding (GO:0000988) 3.352BRCA1, TSG101
1-phosphatidylinositol-3-kinase activity (GO:0016303) 5.982ATM, PIK3CA
deoxyribonuclease activity (GO:0004536) 5.482RAD51, XRCC3
tubulin binding (GO:0015631) 4.12BRCA1, BRCA2
protease binding (GO:0002020) 5.082BRCA2, TP53
ATP-dependent DNA helicase activity (GO:0004003) 6.132NBN, BRIP1
nitric-oxide synthase regulator activity (GO:0030235) 7.792ESR1, AKT1
DNA secondary structure binding (GO:0000217) 6.62RAD51, XRCC3
lipid binding (GO:0008289) 3.262ESR1, AKT1
beta-catenin binding (GO:0008013) 5.32ESR1, CDH1
protein phosphatase binding (GO:0019903) 4.932TP53, AKT1
phosphatase binding (GO:0019902) 4.632TP53, AKT1
protein domain specific binding (GO:0019904) 3.322KRAS, CASP8
core promoter binding (GO:0001047) 4.712ESR1, TP53
core promoter sequence-specific DNA binding (GO:0001046) 5.122ESR1, TP53
ubiquitin-protein transferase activity (GO:0004842) 3.732BRCA1, BARD1
protein phosphatase 2A binding (GO:0051721) 6.412TP53, AKT1
nuclease activity (GO:0004518) 4.332RAD51, XRCC3
four-way junction DNA binding (GO:0000400) 7.032RAD51, XRCC3
phosphatidylinositol kinase activity (GO:0052742) 5.812ATM, PIK3CA
endonuclease activity (GO:0004519) 4.782RAD51, XRCC3
recombinase activity (GO:0000150) 7.662RAD51, XRCC3
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228) 3.982ESR1, TP53
purine NTP-dependent helicase activity (GO:0070035) 5.122NBN, BRIP1
ubiquitin binding (GO:0043130) 5.092FAM175A, TSG101
transcription regulatory region sequence-specific DNA binding (GO:0000976) 3.242ESR1, TP53
RNA binding (GO:0003723) 2.362BRCA1, BARD1
protein heterodimerization activity (GO:0046982) 3.642BARD1, TP53

NET-GE enrichment

Term New enriched termICP valueGenes
protein methyltransferase activity (GO:0008276) NEW5.330.036BRCA1, KRAS, TP53, ESR1
nucleic acid binding transcription factor activity (GO:0001071) -2.650.001PHB, ATM, KRAS, BRCA2, ESR1, CASP8, BARD1, TP53, CDH1, RAD51, AKT1, NBN, BRCA1, CHEK2, TSG101
intramolecular oxidoreductase activity (GO:0016860) NEW5.750.018PHB, KRAS, AKT1, ESR1
transcription corepressor activity (GO:0003714) NEW4.330.0PHB, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
transcription coactivator activity (GO:0003713) -4.040.001ATM, ESR1, CASP8, BARD1, TP53, CDH1, AKT1, BRCA1, CHEK2
transcription cofactor activity (GO:0003712) -3.440.0ATM, PHB, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
nucleotide binding (GO:0000166) -1.960.044ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, PHB, CDH1, RB1CC1, PIK3CA, ESR1, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
transferase activity (GO:0016740) -1.950.013PHB, ATM, KRAS, BRCA2, AKT1, CASP8, PPM1D, BARD1, TP53, CDH1, RB1CC1, RAD51, ESR1, PIK3CA, NBN, BRCA1, CHEK2, TSG101
protein binding transcription factor activity (GO:0000988) -3.350.0PHB, ATM, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
regulatory region nucleic acid binding (GO:0001067) -3.030.009PHB, ATM, AKT1, CASP8, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
helicase activity (GO:0004386) -4.690.004ATM, TP53, CHEK2, BRIP1, RAD54L, RAD51
protein kinase binding (GO:0019901) -3.440.006ATM, ESR1, BARD1, PIK3CA, RB1CC1, TP53, AKT1, BRCA1, CHEK2, RAD51
kinase binding (GO:0019900) -3.320.002ATM, KRAS, AKT1, BARD1, PIK3CA, RB1CC1, TP53, ESR1, BRCA1, CHEK2, RAD51
protein domain specific binding (GO:0019904) -3.320.006ATM, KRAS, AKT1, CASP8, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
binding, bridging (GO:0060090) NEW4.570.002KRAS, ESR1, TP53, RB1CC1, PIK3CA, AKT1, BRCA1
transcription regulatory region DNA binding (GO:0044212) -3.030.008PHB, ATM, AKT1, CASP8, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) -3.030.0PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, TP53, CDH1, PIK3CA, ESR1, RAD54L, BRIP1, CHEK2, RAD51
carbohydrate derivative binding (GO:0097367) -2.030.013PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, RAD51, ESR1, PIK3CA, NBN, CHEK2, RAD54L, BRIP1, BRCA1, HMMR
hydrolase activity, acting on acid anhydrides (GO:0016817) -3.030.0ATM, PHB, XRCC3, KRAS, BRCA2, AKT1, TP53, CDH1, PIK3CA, ESR1, RAD54L, BRIP1, CHEK2, RAD51
sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0000981) -3.290.002PHB, ATM, NBN, AKT1, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
phospholipase activity (GO:0004620) NEW5.160.008ATM, TP53, CASP8, AKT1, CDH1
lipase activity (GO:0016298) NEW4.960.015ATM, TP53, CASP8, AKT1, CDH1
cytokine receptor binding (GO:0005126) NEW4.140.002ATM, KRAS, ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1
cytokine activity (GO:0005125) NEW4.340.012ATM, ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1
RNA polymerase II regulatory region DNA binding (GO:0001012) NEW3.360.014ATM, AKT1, CASP8, TP53, ESR1, BRCA1, CHEK2, TSG101
enhancer sequence-specific DNA binding (GO:0001158) NEW5.360.003TP53, BRCA1, ESR1, CHEK2, AKT1
steroid hormone receptor binding (GO:0035258) NEW5.320.044BRCA1, ESR1, TP53, AKT1
ATPase activity (GO:0016887) -3.650.01PHB, ATM, BRCA2, XRCC3, TP53, ESR1, BRIP1, RAD51
DNA binding (GO:0003677) -1.920.003PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, PALB2, BARD1, TP53, CDH1, RAD51, ESR1, NBN, CHEK2, BRCA1, BRIP1, RAD54L, TSG101
nucleoside phosphate binding (GO:1901265) -1.960.044ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, PHB, CDH1, RB1CC1, PIK3CA, ESR1, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
ATPase activity, coupled (GO:0042623) -3.970.007PHB, ATM, XRCC3, TP53, ESR1, BRIP1, RAD51
transcription factor binding transcription factor activity (GO:0000989) -3.360.0ATM, PHB, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
ribonucleoside binding (GO:0032549) -2.220.017ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, PHB, CDH1, PIK3CA, ESR1, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
purine nucleotide binding (GO:0017076) -2.190.022PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, NBN, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
oxidoreductase activity (GO:0016491) NEW3.120.024ATM, ESR1, BARD1, TP53, CDH1, RB1CC1, NQO2, AKT1, BRCA1, CHEK2, HMMR
histone deacetylase binding (GO:0042826) NEW5.080.049PHB, ATM, ESR1, TP53
ATP binding (GO:0005524) -2.430.002ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, PHB, CDH1, PIK3CA, ESR1, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
GTP binding (GO:0005525) NEW3.780.045ATM, KRAS, ESR1, CDH1, PIK3CA, AKT1, CHEK2, RAD51
tumor necrosis factor receptor superfamily binding (GO:0032813) NEW5.890.004ATM, CASP8, TP53, AKT1
protein kinase regulator activity (GO:0019887) NEW4.60.006ATM, ESR1, TP53, PIK3CA, AKT1, BRCA1
1-phosphatidylinositol-3-kinase activity (GO:0016303) -5.980.019ATM, PIK3CA
kinase activity (GO:0016301) -2.930.02PHB, ATM, KRAS, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
hydrolase activity, acting on ester bonds (GO:0016788) -3.10.001ATM, ESR1, CASP8, PPM1D, BARD1, TP53, CDH1, PIK3CA, AKT1, CHEK2, BRCA1, RAD54L, RAD51
ubiquitin-protein transferase activity (GO:0004842) -3.730.007ESR1, BARD1, CDH1, TP53, AKT1, BRCA1, CHEK2
RNA polymerase II transcription factor binding (GO:0001085) NEW5.080.012TP53, BRCA1, ESR1, CHEK2, CDH1
DNA-dependent ATPase activity (GO:0008094) -5.310.0ATM, RAD51, BRIP1, TP53, XRCC3
protein binding, bridging (GO:0030674) NEW4.680.014ESR1, KRAS, RB1CC1, TP53, AKT1, BRCA1
phosphatidylinositol kinase activity (GO:0052742) -5.810.044ATM, PIK3CA
transferase activity, transferring phosphorus-containing groups (GO:0016772) -2.770.019PHB, ATM, KRAS, NBN, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
glycosaminoglycan binding (GO:0005539) NEW4.420.0ATM, AKT1, CASP8, TP53, RB1CC1, CDH1, ESR1, BRCA1, CHEK2, HMMR
guanyl nucleotide binding (GO:0019001) NEW3.730.01ATM, KRAS, ESR1, TP53, CDH1, PIK3CA, AKT1, CHEK2, RAD51
transcription regulatory region sequence-specific DNA binding (GO:0000976) -3.240.035ATM, AKT1, CASP8, TP53, ESR1, BRCA1, CHEK2, TSG101
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) NEW3.370.013ATM, AKT1, CASP8, TP53, ESR1, BRCA1, CHEK2, TSG101
regulatory region DNA binding (GO:0000975) -3.030.009PHB, ATM, AKT1, CASP8, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
purine ribonucleotide binding (GO:0032555) -2.20.019PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, NBN, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
gamma-tubulin binding (GO:0043015) NEW6.560.021BARD1, BRCA1, BRCA2
protein dimerization activity (GO:0046983) -2.720.0ATM, PHB, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, RAD51, ESR1, PIK3CA, BRCA1, BRIP1, CHEK2, TSG101
protein heterodimerization activity (GO:0046982) -3.640.002ATM, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, ESR1, BRCA1, CHEK2
purine ribonucleoside binding (GO:0032550) -2.220.017PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, NBN, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
ribonucleotide binding (GO:0032553) -2.190.021PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, NBN, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
protein C-terminus binding (GO:0008022) -4.50.001ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1, CHEK2, RAD51
phosphatase activity (GO:0016791) NEW4.110.002ATM, CASP8, PPM1D, TP53, CDH1, AKT1, CHEK2, RAD51
calcium-dependent protein binding (GO:0048306) NEW5.680.001TP53, KRAS, AKT1, TSG101, PIK3CA
enzyme binding (GO:0019899) -2.270.0ATM, NBN, SLC22A18, KRAS, BRCA2, AKT1, CASP8, PPM1D, BARD1, TSG101, TP53, PHB, CDH1, RB1CC1, RAD51, PIK3CA, ESR1, BRCA1, CHEK2, HMMR
phosphoric ester hydrolase activity (GO:0042578) NEW3.820.031ATM, CASP8, PPM1D, TP53, CDH1, AKT1, CHEK2, RAD51
enzyme inhibitor activity (GO:0004857) NEW3.780.013ATM, ESR1, CASP8, BARD1, PIK3CA, CDH1, TP53, AKT1, BRCA1
kinase regulator activity (GO:0019207) NEW4.50.017ATM, ESR1, TP53, PIK3CA, AKT1, BRCA1
anion binding (GO:0043168) NEW4.170.011PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, RAD51, ESR1, PIK3CA, NBN, CHEK2, RAD54L, BRIP1, BRCA1, TSG101
sequence-specific DNA binding (GO:0043565) -2.790.0ATM, NBN, KRAS, BRCA2, AKT1, CASP8, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
structure-specific DNA binding (GO:0043566) -4.980.0ATM, XRCC3, BRCA2, ESR1, TP53, CDH1, AKT1, CHEK2, RAD51
receptor regulator activity (GO:0030545) NEW5.910.029TP53, ESR1, AKT1, CDH1
guanyl ribonucleotide binding (GO:0032561) NEW3.730.01ATM, KRAS, ESR1, TP53, CDH1, PIK3CA, AKT1, CHEK2, RAD51
protease binding (GO:0002020) -5.080.008PHB, CASP8, BRCA2, TP53, AKT1
protein complex binding (GO:0032403) -3.090.008ATM, KRAS, AKT1, CASP8, RAD51, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
double-stranded DNA binding (GO:0003690) -3.090.0ATM, XRCC3, ESR1, CDH1, TP53, AKT1, RAD51
protein homodimerization activity (GO:0042803) -3.160.0ATM, PHB, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, RAD51, ESR1, PIK3CA, BRCA1, BRIP1, CHEK2, TSG101
transporter activity (GO:0005215) NEW2.570.008ATM, PHB, SLC22A18, KRAS, AKT1, CASP8, BARD1, RAD51, TP53, CDH1, RB1CC1, PIK3CA, ESR1, TSG101
transcription factor binding (GO:0008134) -3.460.0PHB, ATM, XRCC3, NBN, AKT1, CASP8, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
protein kinase inhibitor activity (GO:0004860) NEW5.280.027ATM, BRCA1, ESR1, AKT1
cofactor binding (GO:0048037) NEW4.160.042PHB, ESR1, CDH1, RB1CC1, TP53, AKT1, CHEK2
enhancer binding (GO:0035326) NEW5.210.008TP53, BRCA1, ESR1, CHEK2, AKT1
cysteine-type endopeptidase inhibitor activity (GO:0004869) NEW5.710.001TP53, CASP8, ESR1, AKT1, CDH1
ubiquitin protein ligase binding (GO:0031625) -4.170.0ATM, SLC22A18, CASP8, TP53, AKT1, BRCA1, CHEK2, TSG101
protein N-terminus binding (GO:0047485) -5.110.0ATM, NBN, BARD1, TP53, AKT1, CHEK2, TSG101
adenyl nucleotide binding (GO:0030554) -2.40.002PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, NBN, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001228) -3.980.017NBN, ESR1, TP53, AKT1, BRCA1, CHEK2, TSG101
phosphotransferase activity, alcohol group as acceptor (GO:0016773) -3.080.006PHB, ATM, KRAS, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
RNA binding (GO:0003723) -2.360.003PHB, NBN, KRAS, AKT1, CASP8, PPM1D, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, BRIP1, RAD51
protein binding (GO:0005515) -0.460.0ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, SLC22A18, BARD1, CDH1, AKT1, BRIP1, BRCA2, RAD51, ESR1, CHEK2, TSG101
receptor binding (GO:0005102) -2.430.003ATM, PHB, XRCC3, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, HMMR, CHEK2, TSG101
p53 binding (GO:0002039) NEW5.530.009ESR1, RAD51, TP53, CDH1
damaged DNA binding (GO:0003684) -5.580.0ATM, NBN, BRCA1, RAD51, TP53
small conjugating protein ligase binding (GO:0044389) -4.150.0ATM, SLC22A18, CASP8, TP53, AKT1, BRCA1, CHEK2, TSG101
phosphatidylinositol 3-kinase activity (GO:0035004) -5.490.019ATM, PIK3CA
purine nucleoside binding (GO:0001883) -2.220.017PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, NBN, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
nucleoside binding (GO:0001882) -2.210.018ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, PHB, CDH1, PIK3CA, ESR1, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
oxidoreductase activity, acting on CH or CH2 groups (GO:0016725) NEW7.440.004BARD1, ESR1, AKT1
pyrophosphatase activity (GO:0016462) -3.040.0PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, TP53, CDH1, PIK3CA, ESR1, RAD54L, BRIP1, CHEK2, RAD51
structural molecule activity (GO:0005198) NEW3.10.006KRAS, ESR1, CASP8, TP53, CDH1, RB1CC1, RAD51, AKT1, BRCA1, BRIP1, TSG101
protein serine/threonine kinase activity (GO:0004674) -3.640.028PHB, ATM, ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1, CHEK2
protein kinase activity (GO:0004672) -3.270.01ATM, PHB, KRAS, ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1, CHEK2, RAD51
kinase inhibitor activity (GO:0019210) NEW5.250.039ATM, BRCA1, ESR1, AKT1
nitric-oxide synthase regulator activity (GO:0030235) -7.790.006ESR1, AKT1
nucleoside-triphosphatase activity (GO:0017111) -3.090.0PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, TP53, CDH1, PIK3CA, ESR1, RAD54L, BRIP1, CHEK2, RAD51
ligase activity (GO:0016874) -3.720.013ATM, BARD1, CDH1, TP53, ESR1, BRCA1, CHEK2, RAD51
sequence-specific DNA binding transcription factor activity (GO:0003700) -2.650.001PHB, ATM, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, RAD51, ESR1, NBN, BRCA1, CHEK2, TSG101
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.2624ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1, BRIP1, HMMR, BRCA2, RAD51, ESR1, CHEK2, TSG101
metabolic process (GO:0008152) 0.5824ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, AKT1, BRIP1, HMMR, BRCA2, NQO2, RAD51, ESR1, CHEK2, TSG101
organic substance metabolic process (GO:0071704) 0.6323ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, AKT1, BRIP1, HMMR, BRCA2, TSG101, ESR1, CHEK2, RAD51
macromolecule metabolic process (GO:0043170) 0.8323ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, AKT1, BRIP1, HMMR, BRCA2, TSG101, ESR1, CHEK2, RAD51
primary metabolic process (GO:0044238) 0.6922ATM, PALB2, TP53, FAM175A, RB1CC1, KRAS, XRCC3, RAD54L, PHB, CASP8, PPM1D, PIK3CA, BRCA1, NBN, BARD1, AKT1, BRIP1, BRCA2, TSG101, ESR1, CHEK2, RAD51
response to stimulus (GO:0050896) 1.2222ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1, BRIP1, BRCA2, ESR1, CHEK2, RAD51
biological regulation (GO:0065007) 0.3922ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1, BRIP1, BRCA2, TSG101, ESR1, CHEK2, RAD51
regulation of biological process (GO:0050789) 0.4522ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1,