Disease table of BREAST CANCER OMIM ID: 114480

Gene-disease associations table

Gene	Associated with BREAST CANCER in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
TSG101	OMIM	HGNC link	11p15.1	1	114480
HMMR	OMIM	HGNC link	5q34	1	114480
ATM	OMIM	HGNC link	11q22.3	2	208900, 114480
NQO2	OMIM	HGNC link	6p25.2	1	114480
AKT1	OMIM, HUMSAVAR	HGNC link	14q32.33	6	167000, 176920, 114480, 181500, 114500, PS158350
BRIP1	OMIM, HUMSAVAR	HGNC link	17q23.2	2	PS227650, 114480
XRCC3	OMIM	HGNC link	14q32.33	2	PS155600, 114480
RB1CC1	OMIM	HGNC link	8q11.23	1	114480
PPM1D	OMIM	HGNC link	17q23.2	1	114480
RAD54L	OMIM	HGNC link	1p34.1	2	605027, 114480
FAM175A	HUMSAVAR	HGNC link	4q21.23	1	114480
NBN	HUMSAVAR	HGNC link	8q21.3	4	609135, 613065, 114480, 251260
CDH1	OMIM	HGNC link	16q22.1	5	608089, 167000, 176807, 137215, 114480
CHEK2	OMIM, HUMSAVAR	HGNC link	22q12.1	4	PS151623, 176807, 259500, 114480
BRCA1	HUMSAVAR	HGNC link	17q21.31	5	PS227650, 167000, 614320, PS604370, 114480
BRCA2	OMIM, HUMSAVAR	HGNC link	13q13.1	8	PS227650, PS194070, 155255, 114480, 176807, PS137800, 613347, PS604370
BARD1	OMIM	HGNC link	2q35	1	114480
BCPR	OMIM	HGNC link	17-	1	114480
KRAS	OMIM	HGNC link	12p12.1	14	601626, 600268, 137215, 109800, PS163950, 211980, 114480, PS115150, 613659, 163200, 607785, 614470, 162900, 260350
TP53	OMIM	HGNC link	17p13.1	12	114550, 260500, 605027, PS137800, 614740, 114480, 260350, 607107, 202300, 114500, PS151623, 259500
SLC22A18	OMIM	HGNC link	11p15.4	3	114480, 268210, 211980
ESR1	OMIM	HGNC link	6q25.1	4	608446, 157300, 615363, 114480
PHB	OMIM	HGNC link	17q21.33	1	114480
PALB2	OMIM	HGNC link	16p12.2	3	PS227650, 114480, 613348
CASP8	OMIM	HGNC link	2q33.1	4	114550, 607271, 211980, 114480
RAD51	OMIM, HUMSAVAR	HGNC link	15q15.1	2	PS157600, 114480
PIK3CA	OMIM, HUMSAVAR	HGNC link	3q26.32	11	114550, PS158350, 167000, 612918, 211980, 114480, 602501, 114500, 182000, 162900, 613659

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
17q23.2	2	BRIP1, PPM1D
14q32.33	2	AKT1, XRCC3

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
17q21	2	BRCA1, PHB
14q32	2	AKT1, XRCC3
17q23	2	BRIP1, PPM1D
11p15	2	TSG101, SLC22A18

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
17q2	4	BRCA1, BRIP1, PPM1D, PHB
2q3	2	BARD1, CASP8
11p1	2	TSG101, SLC22A18
14q3	2	AKT1, XRCC3

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
2q	2	BARD1, CASP8
14q	2	AKT1, XRCC3
11p	2	TSG101, SLC22A18
8q	2	RB1CC1, NBN
17q	4	BRCA1, BRIP1, PPM1D, PHB

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
11	3	TSG101, SLC22A18, ATM
14	2	AKT1, XRCC3
17	5	BRCA1, TP53, BRIP1, PPM1D, PHB
16	2	CDH1, PALB2
2	2	BARD1, CASP8
6	2	NQO2, ESR1
8	2	RB1CC1, NBN

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
TSG101	YES	3	REG4, EGFR, MDM2	0
ATM	YES	21	PVR, SP1, CDKN1A, BAX, MCL1, FOXM1, BCL2, FAS, TERF1, IGF1R, TNFRSF10B, SLC2A1, TP53, GADD45A, KLRK1, PMAIP1, DUSP1, CFLAR, VEGFA, HIPK2, MTF1	1	TP53
BRIP1	YES	1	BARD1	1	BARD1
RB1CC1	YES	1	RB1	0
BRCA1	YES	52	ATM, RNASEL, DDIT3, KRT5, JAK2, MAD2L1, IRF7, EGFR, HSPA5, FOS, XPC, STAT2, EGR1, CCND1, AREG, FST, HNRNPA2B1, STAT1, CASR, E2F6, ESR1, SIRT1, DDB2, CDKN1A, KRT18, CXCL1, FOXC1, FOXC2, IFNA1, CDH3, CYP1A1, CTSD, IGF1, KHSRP, CYP19A1, HMGA2, EP300, KRT17, TFF1, STAT3, BRCA2, ASPM, TP63, IGF1R, GADD45A, JAK1, CDKN1B, CCNB1, MYC, VEGFA, IRF9, HIF1A	3	ATM, BRCA2, ESR1
BARD1	YES	1	ESR1	1	ESR1
TP53	YES	159	ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING1	6	BRCA2, ESR1, TP53, AKT1, BRCA1, CHEK2
ESR1	YES	68	UGT2B15, AR, PELP1, EGFR, FLT1, RET, AVP, NRF1, CDK4, SERPINE1, PGR, FOS, VEGFA, CHAT, RUNX2, ZFHX3, CYP19A1, SERPINB9, TYMS, DCT, CXCL12, PTMA, HTRA2, NR5A2, CD24, HSPB1, CYP1B1, CTNNB1, MMP13, BRCA1, CYP2C19, BLM, OXT, TAC3, CCNA2, ZEB1, CDKN1A, STAT5A, TERT, MDM2, PMAIP1, CYP1A1, RARA, TP53, JUN, CDH1, AMH, CRHBP, MYC, TFF1, E2F1, CRH, KDR, BTG2, BCL2, UGT1A4, TGFA, KRT19, F12, FOXP1, ESRRA, GREB1, CTSD, JUNB, ESR1, YWHAQ, CCND1, CDKN1B	4	BRCA1, ESR1, TP53, CDH1
RAD51	YES	1	HR	0
DNMT1	NO	24	MBD2, BIRC5, IL32, CDKN2A, CDKN2B, TIMP3, CASP8, PROM1, CXCR4, BAG1, TERT, GAD1, TNFRSF10B, CDH1, VEGFA, RELN, EPCAM, MGMT, IL3, KIR2DL3, RUNX3, RB1, BMP2, MSH2	2	CASP8, CDH1
MYC	NO	102	CBFB, PRDX3, CHKA, ATF3, CDK4, PCNA, CEBPA, LDHA, DKK1, MTDH, TFAP4, HLA-G, CDC25A, UBE2C, HLA-B, GATA1, TP53, BAG2, PMAIP1, CDK6, WRN, PGK1, TFAM, IGK, JUNB, ZFP36, HNRNPA1, MYB, SART3, EBNA1BP2, TOP1MT, ST3GAL4, CD33, CCND2, PTBP1, CDCA7, RB1, CCNA2, HLA-C, CYP3A4, FMR1, TERT, NFE2, MME, NDRG1, HDAC2, BRD7, FASLG, CCNB1, TP73, RCC1, SFRP1, HLA-F, CFLAR, BCAT1, CD38, TFRC, CCND1, MTA1, KRAS, HNRNPA2B1, CDC34, ST3GAL3, HLA-A, FUT3, NOL7, FTH1P18, VEGFA, EP300, CDK2, ASS1, SURF1, CDC25C, IER3, ST3GAL1, FOXM1, HSPA4, XPO1, CAD, SHMT1, DDX18, IGF2BP1, BMI1, IPO7, BCL2, CXCR4, SRSF1, TLX1, PRODH, NBN, CDKN1A, IFNA1, TNFRSF10B, ID2, CCNE1, SURF2, HLA-E, CREBBP, MAPK1, IL6, EIF4E, ODC1	3	NBN, KRAS, TP53
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	4	ATM, BRCA1, ESR1, NQO2
KLF4	NO	30	ATF3, IVL, GDF15, KRT19, BIRC5, TP53, MMP2, BDKRB2, IFITM3, GPA33, CCND1, LAMA3, THBD, ALPI, IL1B, CDKN1A, VDR, CDH1, RARA, NANOG, HDC, LXN, CYP1A1, HSPA8, CDKN1C, IL6, CDKN1B, CCNB1, ODC1, CDH5	2	TP53, CDH1
CREB1	NO	90	NDC80, NRF1, IFNG, NR2F1, CYP19A1, CASP8, LDHA, SMAD6, SLC19A1, GSK3A, IL10, PSEN1, PPP2R2B, JUN, HPGD, IL2, GABPA, MC2R, CRTC1, AR, FLT1, SLC39A1, BDKRB2, NPY, PTGS2, MSMB, CFTR, HMOX1, MITF, AQP3, MUC5AC, STMN1, TRH, PCSK1, MMP2, CYP17A1, NOLC1, PRL, NMNAT2, TLR9, NTS, PLAT, FOS, BCL2L11, MUC4, GSK3B, CYP11B1, PPM1D, CCK, ETV3, PTGES, UXT, HLA-DOB, CGA, XPC, ACACA, SLC22A8, TH, VIP, BDKRB1, CYP11B2, POLD2, LAPTM4B, SOX9, PLAU, SNAI1, PPP2CA, SNAI2, SPRY2, HLA-DQB1, CCL5, CXCR4, ADRA1A, NR5A2, ERBB2, GRPR, BDNF, NR4A3, IL5RA, SLC20A1, RRM2B, LYL1, BCL2, CD4, NR2F6, NF1, IL6, CYP11A1, ODC1, FOXA1	2	PPM1D, CASP8
GATA3	NO	33	IL12RB2, KLK1, CHST4, IFNG, EPO, ERVW-1, TEK, MUC1, CD40LG, HSD17B1, TRA, ERG, ESR1, FUT7, ZEB1, CDH3, CDX2, FOXC1, FOXC2, PAEP, IL10, CDH1, MMP1, CD8A, DLC1, CXCL1, GATA3, IL4, IL5, EPOR, CD8B, STAT4, MYCN	2	ESR1, CDH1
CTBP1	NO	4	BRCA2, BRCA1, CLDN7, KRT18	2	BRCA1, BRCA2
ID4	NO	2	BRCA1, ESR1	2	BRCA1, ESR1
VDR	NO	36	DKK4, CST5, PRL, LRP5, IGFBP3, BGLAP, EGFR, TPT1, IL12B, SKP2, PHB, CYP7A1, RUNX2, TNFRSF21, CYP1A1, ERBB2, CD14, CYP24A1, CYP3A4, CDKN1B, FOXP3, PODXL, IL10, HOXA10, CDH1, CALB1, SPP1, AMH, TRPV6, DDIT4, CXCL8, IL2, PTH, IL6, CAMP, TNFSF11	2	PHB, CDH1
JUN	NO	155	PTN, TXN, ATF3, MEF2D, SMN1, TP53, MMP2, SPRR1B, EDN1, TNFRSF1B, NQO1, ELN, CYP19A1, GJA1, MAP3K1, ACTA1, STAR, NEIL1, ALOX12, PPARA, LOR, SLC19A1, NOS2, IFNB1, IL1B, MGMT, FGF7, JUN, ETS2, GSTP1, PCK2, BECN1, ITGB8, MMP3, CREM, IL23A, HEY1, FOSL1, CCL2, TERT, NAMPT, FASLG, BCL2L1, EGFR, RUNX2, CDKN1A, EZH2, MYB, DCN, NPY, PLAT, RARG, PTGS2, MAPK8, CCND2, NGF, TFF1, TNF, LBP, NFKB2, CYP2J2, NOX5, BEX2, NOS3, RARA, MMP1, F3, ETS1, ABCB1, STMN1, PLAUR, TNFRSF10A, IBSP, DDX21, TP73, SPRR3, PPARD, UGT2B15, RARB, IFNG, IL12A, AR, OPRM1, REN, NTS, MSR1, SYK, FOS, APP, CDK5R1, ITGAX, CCND1, CCK, PDK1, CYP1A2, BRCA1, CTSL, MMP20, MAT2A, PDHA1, SPP1, TIMP2, OXTR, VEGFA, SOX7, RHOB, CA2, IL24, CXCL8, IL2, EZR, IL1A, APOC3, MMP9, FGL2, NEFL, SOD2, BATF3, POLD2, FIGF, PLAU, DDIT3, PENK, PGR, IL12B, LGALS3, RELB, LDHA, CCL5, FAS, SMAD7, GCLC, MMP7, CD82, CYP11A1, MGP, ATG5, CSF2, SPI1, VDR, MFI2, MMP12, CTGF, IL5RA, VCAM1, CSF1, TNC, APOM, IL3, CD69, IL6, MMP13, CSTA, KRT16, MYC	2	BRCA1, TP53
SIRT1	NO	43	ACAN, TBX3, ESRRG, EZH2, CFLAR, NR1I2, FOXO3, SELE, HSF1, ABCB1, TP73, CCND1, NR5A2, CFH, HYOU1, IL1B, SHC1, COL1A2, NBN, CDKN1A, CTNNB1, MCL1, TNFRSF10B, BCL11A, CDH1, PARP1, ICAM1, PAX6, DLL4, SIRT6, NOTCH1, WRN, ADAMTS5, NDRG1, PER1, TNF, MMP9, COL10A1, TP53, EGLN1, MYC, PPARG, HIF1A	3	NBN, TP53, CDH1
PARP1	NO	25	FN1, SNAI1, IFNAR1, IFNG, VIM, SERPINE1, TERF2, TCF4, THBD, FOXO1, E2F1, CDKN1A, SMARCB1, CDH1, SH3BP2, FBN1, IL10, RELA, NFKB1, CXCL1, BRCA2, BCL2, HTR1A, JUN, SERPINF1	2	BRCA2, CDH1
CREBBP	NO	27	ALOX15, CLOCK, CSF2, TP53, CREB1, EGFR, PTGS2, IL4, LDHA, INSM1, HOXA9, CCK, ONECUT1, BRCA1, PPARA, RS1, CDKN1A, RARA, TRIM22, NPAS2, EP300, PCK2, HOXA10, IRF1, PSMC5, HINFP, RAD51	3	BRCA1, RAD51, TP53
HDAC1	NO	64	NFYA, PSIP1, RECK, EIF2AK1, RARB, BIRC3, IGFBP3, CD1D, HSPA5, FOS, CDKN2A, TXNIP, PTGS2, RUNX3, NOS3, RHOB, MICA, EGR1, FAS, KLF4, CLDN7, HMGCS1, CD44, CCND2, MICB, CD82, RECQL4, GRIN2B, SP1, SERPINB5, PHB, BIRC5, COMP, CDC25A, ESR1, FSHR, HOXA9, AR, GAD1, RELN, KLK3, CDH1, SPP1, TP53, PCNA, CXCL8, ICAM1, MGMT, TFF1, EPCAM, STAT3, BRCA2, ABCB1, BCL2A1, SNAI2, HLA-DRA, CDKN1A, MMP28, MMP9, TJP1, TERT, IL2, CCND1, CDKN1B	5	PHB, ESR1, BRCA2, TP53, CDH1
HDAC2	NO	22	TWIST1, SNAI2, CAD, CCL2, CD1D, SP1, CCNE1, MUC5AC, KLF4, BMP7, PHB, CDKN1A, PRDX2, IGF1, TNFSF10, CDH1, CXCL8, ALOX5, APAF1, GRM2, MYC, MYCN	2	PHB, CDH1
YY1	NO	74	FCER1A, CFTR, EGFR, GDAP1, POSTN, TP53, ATP2C1, IFNG, ADORA2A, KIR3DL1, TOP3A, HBE1, LDLR, SERPINE1, LRIG2, HSPA5, GBP1, HLA-DRA, APC, HAS2, CCL13, SNRPN, FMO3, TFRC, CTCF, FAS, TF, CXCR4, FCGR3B, DNAJB4, HSD3B2, ERBB2, SURF1, TDO2, IVL, BRCA1, DEK, COX7C, CETP, ERCC5, NOS2, BDKRB1, SLC26A3, EPAS1, ACTC1, ZNF175, BAP1, TNFRSF10B, HOXB7, NF1, OPRM1, PCNA, PARP1, PRDM2, VWF, TP73, CCR5, CBX5, SURF2, IL4, NR3C1, PDIA6, CYP3A5, CREBBP, HCFC1, IL5, DBH, RB1, FDPS, FCGR2B, LSS, MYC, HOXB13, COL1A2	2	BRCA1, TP53
HDAC9	NO	22	MYEF2, SOX9, PRL, TP53, DIRAS3, CFLAR, CDKN2A, STAT6, HSPA5, APP, CITED2, IGFBP1, CDKN1A, CLGN, TNFRSF10B, RELA, HPGD, NFKB1, MEF2A, IL18, MMP13, ESR1	2	ESR1, TP53
STAT3	NO	129	IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP12	4	PHB, TP53, AKT1, CDH1
USF2	NO	42	PF4, FCER1A, CTSB, IGF2R, NR5A1, CEACAM1, MYH9, TRAP, ASPH, CEACAM5, TOP3A, PTGS2, PDX1, CYP19A1, HOXB4, THBS1, CFTR, TCN2, TGFB1, PKLR, FMR1, SLC19A1, APC, CD2, TGFB2, PIGR, CTSD, ASCL2, PTPN6, CXCR4, BRCA1, FBP1, BRCA2, CXCR2, ATP5A1, APOA2, APOA5, B2M, HMOX1, TERT, ABCA1, LIPC	2	BRCA1, BRCA2
IFI16	NO	6	WT1, AR, TP53, MYC, ICAM1, BRCA1	2	BRCA1, TP53
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	4	TP53, BRCA2, AKT1, CDH1
RBL2	NO	3	BRCA1, RAD51, E2F4	2	BRCA1, RAD51
HMGA1	NO	17	PTGS2, SP1, CXCL1, XPA, POU1F1, INSR, CRYAB, CDC25A, TWIST1, IL1B, CDH1, CD44, TP53, RAG2, SLC2A3, BRCA1, KL	3	BRCA1, TP53, CDH1
EP300	NO	56	ALOX15, PCNA, MDM2, VCAM1, EIF2AK1, PTGS2, BIRC5, IFNG, EPO, PARP1, TBXAS1, BGLAP, CDKN2B, IL12B, RS1, LDHA, CCNE1, ABCB1, TP73, KLF5, LAMA3, HINFP, THBD, ERBB2, DNMT1, BRCA1, WT1, CCNB2, CDKN1A, ZEB1, GFAP, TRIM22, SPP1, CYBB, RELA, NPAS2, CXCL8, VEGFA, NFKB1, CRABP1, CA9, NR0B2, NR1H4, CREBBP, CLOCK, IGFBP3, IL5, IL6, SLC9A2, MMP9, IGF1, KRT16, MYC, CCND1, PML, RAD51	2	BRCA1, RAD51
RELA	NO	302	NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC6	4	TP53, BRCA2, AKT1, CDH1
EZH2	NO	31	PCNA, SFRP1, ADRB2, TWIST1, SNAI2, CDKN2B, CDKN2A, APC, RUNX3, PIP5K1C, CCNE1, DACT3, HOXB13, ALDH1A1, BRCA1, FOXC1, CDKN1A, VDR, HDAC1, RPLP0, CDH1, SATB1, TP53, AXL, ADAMTS1, SSTR1, FBXO32, MMP2, PEBP1, CIITA, CCND1	3	BRCA1, TP53, CDH1
TWIST1	NO	35	ATM, AKR1C2, CDH2, GDF15, MAPK1, FN1, RBL2, NR2F1, MYB, MMP2, RAP1A, BMI1, FOS, FGF2, RUNX2, ITGB1, CD44, ERBB3, PFDN4, DKK1, AKT2, ESR1, F2R, CDH1, NF1, TIMP1, ICAM1, BCL2, ILK, MAPK3, MMP1, YBX1, CTPS1, SRPX, DNM3	3	ATM, ESR1, CDH1
TWIST2	NO	25	ATM, AKR1C2, GDF15, POSTN, FN1, RBL2, NR2F1, MYB, RAP1A, FOS, RUNX2, ITGB1, CD44, ERBB3, DKK1, F2R, CDH1, NF1, CDH2, ICAM1, ILK, PFDN4, MMP2, CTPS1, SRPX	2	ATM, CDH1
RB1	NO	29	CDK1, DDIT3, BIRC5, MAP3K5, EBNA1BP2, DNMT3A, FOS, SFTPD, SP1, DHFR, HBP1, BRCA1, CDKN1A, RBL1, TFDP1, CDH1, ATF2, PCNA, E2F2, ELF1, E2F1, WRN, FGFR1, TP53BP2, RB1, IGF1, MYC, PPARG, E2F3	2	BRCA1, CDH1
ETS1	NO	90	PF4, ITGB3, TP53, TBXAS1, GABRE, PTHLH, TNFSF14, CD14, IGFBP1, BAX, SLC26A3, IL2, MGAT5, VWF, HPGD, CA9, MMP3, MMP9, CSF3R, IL2RB, TERT, THY1, FLT1, FGFBP1, CSF2, MYB, FLI1, ANGPT2, GP6, EGR1, TMEM158, CSNK2B, ERG, SQSTM1, WAS, F13A1, CD8A, MMP1, TGFBR2, ABCB1, ATXN2, NDRG1, SPRY2, HSPB8, BMP4, PRL, TBXA2R, CDKN2A, CHUK, NKX3-1, TAF12, MUC4, HSPE1, TRB, AXIN1, BRCA1, LCK, MMP10, SPP1, RHOC, ICAM1, ANPEP, CSNK2A1, IL5, CR1, HSPA6, HMOX1, CASP1, MDM2, PLAU, SNAI1, TFAP2A, CTSB, TRA, CXCR4, ECE1, SRD5A1, HSPA1L, DUSP6, CDKN1A, FOXD1, GRPR, CTGF, PARP1, TNC, HSPA8, IL3, COL1A1, MMP13, CD6	2	BRCA1, TP53
MTA1	NO	20	EPHA2, NOS2, MMP9, EGFR, MNAT1, MTA3, SNAI1, SMAD7, BCL2L1, CDH1, MYC, CDKN1A, SNAI2, PTEN, ITGB3BP, ESR1, CDKN2A, SUMO2, BRCA1, TFF1	3	BRCA1, ESR1, CDH1
NR3C1	NO	36	CALD1, PNRC1, TP53, RPS6KA3, BAX, SRF, SLC10A2, SCNN1A, BGLAP, TAT, RLN2, S100P, CYP19A1, MUC4, CCND1, NR1I2, ETS1, PPIG, BRCA1, ELK1, CSF1R, CDKN1A, UGT1A1, RLN1, SPP1, BAD, NFKB1, STAT1, COX1, NR3C1, CDK4, CDK6, CCND3, ATP1B1, ATF2, MAOA	2	BRCA1, TP53
AR	NO	83	UGT2B15, PTPN1, CDH11, AKR1C3, USP26, FOLH1, CCR2, CDK20, CDK6, PNRC1, ARG1, XIAP, VIM, ARG2, EGFR, CFLAR, ETV1, BSG, IGF1R, MUC1, WEE1, PTGS2, NKX3-1, AKT1, NRAS, CDH1, EP300, KLF5, ACTA1, CLK3, FN1, TNF, PRL, ERBB2, ERBB3, CRISP3, CTNNB1, PTEN, CRISP1, SERPINB5, TSC2, NAT1, CDKN1A, GREB1, SEPT7, IFI16, PIGR, KLK3, PC, STIM1, SRD5A3, TCF7L2, JUN, TMPRSS2, RELA, TJP1, BTG1, VEGFA, NFKB1, HMMR, FKBP5, KLK4, CRH, CDH2, BTG2, TGFA, SESN1, CDC6, TH, ALDH1A3, KISS1, KISS1R, PEBP1, KLK2, ATAD2, HMOX1, TSC1, WNT7B, PEG10, TRPS1, CCND1, PIP, FOXA1	3	CDH1, AKT1, HMMR
E2F4	NO	20	AURKB, MYC, TOPBP1, KIAA0101, CDK2, TTK, FGF2, LIN54, BIRC5, HCFC1, MAP3K5, MCM10, PLK1, CCNB1, PEG10, DIRAS3, BRCA1, CCND1, RAD51, E2F2	2	BRCA1, RAD51
E2F1	NO	123	WWOX, DOK1, MEFV, MYBL2, MCM8, FZD1, DIRAS3, PIN1, PCNA, DHFR, ETV4, LRBA, RPA2, FSHR, SERPINB5, PCSK6, TP53, FOXM1, E2F1, IL23A, CD2AP, HMGA1, XRCC1, FHIT, IRF3, ATM, MYC, MT1G, NRIP1, FLT1, RRP1B, MYB, SERPINE1, BMI1, CDKN2A, SKP2, MAPK8, CCNE1, CASP7, CDCA7, HIC1, THBS1, RB1, TNF, IL1B, ULK1, ERCC1, CUX1, TERT, MCL1, AR, KIR3DL1, NPAT, PDK4, DDB2, E2F6, ABCB1, BBC3, AURKA, NOX4, MYCN, CCNB1, TP73, FGFR1, RRM1, RRM2, HSPA5, TLR3, MUC4, CCND1, MCPH1, BRCA1, DRAM1, ERCC5, BIRC5, TYMS, RASGEF1B, MAP1LC3A, VEGFA, RACGAP1, FANCA, UHRF1, CHEK1, MCM5, RASGRP1, APAF1, ISYNA1, ECT2, TNFSF11, AURKB, CDK1, MDM2, DDIT3, MAP3K5, DBF4, PNRC2, KIF2C, POLA1, CTNNBIP1, ELF4, KDR, TP53INP1, ATAD2, CCL3, TK1, ATG5, CDKN1A, SIVA1, PEG10, TOP2A, CDAN1, CHEK2, DUSP1, ASF1B, DAPK2, PTPRO, BCL2, CREBBP, TP53BP2, GINS3, MYH10, PPARG, PPP1R13B	4	ATM, BRCA1, CHEK2, TP53

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
TSG101	YES	2	MAZ, TTF2	0
HMMR	YES	1	AR	0
ATM	YES	6	SP1, TWIST2, BTF3, TWIST1, BRCA1, E2F1	1	BRCA1
NQO2	YES	2	SP1, JUND	0
AKT1	YES	7	APC, STAT3, GLI1, AR, TP53, RELA, NFKB1	1	TP53
PPM1D	YES	1	CREB1	0
NBN	YES	2	MYC, SIRT1	0
CDH1	YES	49	AR, MTA2, FOXM1, ZEB2, SNAI1, TWIST2, TWIST1, EZH2, RBBP7, FOXA2, TCF3, LMO2, SPDEF, YBX1, KLF4, MTA1, LCOR, HDAC3, DNMT1, FOXQ1, HOXA7, TCF12, ESR1, SIRT1, WT1, ZEB1, FOSB, SMARCA4, VDR, HDAC1, TFAP2A, RELA, PARP1, HMGA2, NFKB1, KLF8, HDGF, STAT3, GATA3, HDAC2, SNAI2, CBX7, SALL4, RB1, HMGA1, KLF6, ZNF217, SIX1, HIF1A	1	ESR1
CHEK2	YES	2	E2F1, TP53	1	TP53
BRCA1	YES	33	WWP1, RBL2, EZH2, DLX4, CTBP1, SP1, E2F4, ID4, NCOA3, USF2, MTA1, E2F1, FOSL2, RBL1, FOXP3, IFI16, NFE2L2, SP100, TP53, CTCF, EP300, ETS1, E2F6, NR3C1, YY1, JUN, TP53BP1, RB1, HMGA1, ESR1, AHR, CREBBP, FOXA1	2	ESR1, TP53
BRCA2	YES	11	ESR2, CTBP1, HDAC1, ELF1, TP53, USF2, RELA, PARP1, BRCA1, NFKB1, USF1	2	BRCA1, TP53
BARD1	YES	1	BRIP1	1	BRIP1
KRAS	YES	1	MYC	0
TP53	YES	50	ATM, RELA, ERCC2, ETS2, ELF4, EZH2, HDAC9, FOS, PAX5, MCM4, RUVBL1, ZBTB2, EGR1, KLF4, MCM2, AATF, PAX2, TFDP1, STAT1, IRF1, PAX8, HIPK2, HDAC1, SIRT1, MDM4, VHL, ESR1, ING1, IFI16, STAT3, JUN, TP53, ABL1, NUPR1, NFKB1, E2F1, ETS1, CREBBP, HOXA10, NR3C1, YY1, NF1, ING4, HMGA1, SOX6, BDP1, MYC, PPARG, PML, MYCN	3	ATM, ESR1, TP53
ESR1	YES	27	MECP2, RUNX2, TWIST1, TFAP2C, PGR, HDAC9, NCOR1, SP1, NKX3-1, ARNT, ID4, HDAC7, MTA1, BRCA1, BARX2, XBP1, STAT5A, LEF1, KDM4B, HDAC1, BARD1, STAT5B, PIAS3, TP53, GATA3, NR2E3, ESR1	4	BRCA1, BARD1, TP53, ESR1
PHB	YES	4	VDR, HDAC1, HDAC2, STAT3	0
CASP8	YES	4	RUNX3, MEN1, DNMT1, CREB1	0
RAD51	YES	4	CREBBP, EP300, RBL2, E2F4	0
PIK3CA	YES	1	FOXO3	0
PMAIP1	NO	7	ATM, ESR1, KLF9, TP53, KLF6, TP73, MYC	3	ATM, ESR1, TP53
GADD45A	NO	7	ATM, NFYA, POU2F1, TP53, BRCA1, JUND, POU5F1	3	ATM, BRCA1, TP53
IGF1R	NO	8	WT1, ATM, VHL, TBP, AR, TP53, BRCA1, NKX3-1	3	ATM, BRCA1, TP53
XPC	NO	6	SP1, TP63, CREB1, TP53, BRCA1, HIF1A	2	BRCA1, TP53
CTSD	NO	9	ARNT, ESR2, TP53, USF2, USF1, ESR1, NFATC3, BRCA1, MYCN	3	BRCA1, ESR1, TP53
MDM2	NO	23	TFAP4, TP53, NFATC2, JUND, DNMT3A, SP1, ELF4, ZBTB2, SKI, MLLT10, E2F1, FOSL2, ELL, MLLT3, ETS2, EP300, ETS1, FUS, TSG101, ESR1, NR4A1, TP73, MYCN	3	ESR1, TP53, TSG101
TERT	NO	30	CTCF, MZF1, ETS2, MXD1, USF2, SP1, ID2, TAL1, SMAD3, DNMT1, E2F1, WT1, ESR2, HDAC1, JUN, TP53, RELA, NFKB1, TP73, ETS1, HIF1A, STAT3, MEN1, NFATC2, FLI1, USF1, ESR1, MYC, PITX1, MYCN	2	ESR1, TP53
HIPK2	NO	3	ATM, PML, TP53	2	ATM, TP53
CCND1	NO	62	POU4F2, RELA, E2F4, MYBL2, AR, MECP2, PML, BHLHE41, EZH2, ATF2, PGR, JUND, FOS, PAX5, STAT5B, RUNX3, RNF14, POU2F1, EGR1, EP300, KLF4, HOXA1, STAT5A, CTNNB1, BRCA1, ESR1, SIRT1, VHL, SP1, KLF6, LEF1, HDAC1, KDM4B, NKX3-1, SOX2, HOXB7, JUN, ZNF24, TP53, NANOG, E2F8, NELFCD, NFKB1, E2F1, FHL2, STAT3, TCF4, BTG2, NR3C1, SP4, TSC22D3, SNIP1, HEXIM1, ING4, LIN28A, HIF1A, SMARCA4, SP3, MYC, PPARG, KLF5, SOX6	3	BRCA1, ESR1, TP53
SLC2A1	NO	4	ATM, HDAC5, HIF1A, TP53	2	ATM, TP53
CDKN1B	NO	27	KAT2B, NFYA, TP53, SP1, KLF4, HDAC3, COPS5, FOXO1, BRCA1, VHL, CUX1, ZNF300, VDR, HDAC1, STAT3, NFYC, HOXB7, NR4A1, UTF1, ING4, FHL2, NFYB, PROX1, MEN1, ESR1, IRF9, MYCN	3	BRCA1, ESR1, TP53
CDKN1A	NO	118	ABL1, TFAP4, TP53, MYF5, TCF3, HDAC9, PAX5, ZBTB2, LCOR, E2F3, ZBTB5, HSF1, ELL, TSC22D3, NCOA1, TAF1, RELA, MYOD1, STAT1, PTTG1, KLF16, ESR1, JUNB, MYCN, KAT2B, AR, BCL6, KLF10, EZH2, ARID1A, JUND, SP1, CEBPB, ZFHX3, ZNF300, EGR1, KLF4, AATF, HDAC7, HBP1, SMARCA4, ESR2, FOXP3, RARA, NELFCD, ING4, HDAC4, TBX2, IRF1, HDAC2, ETV6, SIRT2, MYOG, KLF6, TP73, SOX6, ATM, ERCC2, SMAD4, ETS2, NUPR1, PTMA, MLLT10, SMAD3, ETS1, CBX8, BRCA1, HIPK2, SIRT1, WT1, ZNF76, HDAC1, SMAD2, MLLT3, TFAP2A, EP300, FHL2, TP63, IRF9, EHMT2, TFAP2C, NFIX, RUNX3, RB1, HNF4A, NFIB, TAF5, SOX9, TBP, EAPP, ZBTB17, TAF4, REL, RELB, PML, SMAD7, NPM1, POU5F1, E2F1, TBX3, FOXG1, MYF6, NFIA, ATF2, PARP1, NFKB1, STAT3, GFI1, NR3C1, CREBBP, MTA1, JUN, KLF2, CDX2, SP3, MYC, PPARG, ING1	4	ATM, BRCA1, ESR1, TP53
EGR1	NO	17	SP1, ETS2, RELA, ATF5, MAML1, HDAC1, NFKB1, TP53, NAB2, NKX2-3, RBMX, FOXO1, BRCA1, ETS1, STAT6, KLF5, STAT1	2	BRCA1, TP53
CTNNB1	NO	8	AR, NKX2-5, LEF1, TP53, NELFCD, SOX6, ESR1, SIRT1	2	ESR1, TP53
FOS	NO	31	HMGN1, MITF, NCOA6, TBP, SRF, RBMX, FOS, ZBTB7A, SP1, NKX3-1, ARNT, STAT6, CREB1, BRCA1, HOPX, ELK1, TWIST2, ESR1, ESR2, ELK4, HDAC1, NF1, TWIST1, HSF2, GTF2I, STAT3, CREM, JUN, RB1, SMARCA4, AHR	2	BRCA1, ESR1
VEGFA	NO	53	ATM, WT1, AR, FOXM1, ID3, ATF4, COPS5, TFAP2A, EPAS1, PGR, RUNX1, SP1, NKX3-1, TEAD4, ARNT, EGR1, EP300, KLF5, MYC, SMAD3, HDGF, HTATIP2, DNMT1, FOXO3, HIPK2, ZFP36, HEXIM1, VHL, ZFP36L1, XBP1, ESR2, NR1H4, HOXB7, JUN, ZNF24, TP53, RELA, HDAC4, RUNX2, NFKB1, BRCA1, FOXQ1, E2F1, STAT3, UHRF1, TCF4, PTTG1, ZNRD1, HIF1A, ESR1, SP3, MEF2C, E2F3	4	ATM, BRCA1, ESR1, TP53
BTG2	NO	7	AR, RELA, FOXM1, TP53, ESR1, NFKB1, PHB2	2	ESR1, TP53
CYP19A1	NO	23	NR5A1, NR0B1, FOXL2, NR2F1, CREB1, PGR, RARG, SP1, USF2, NR5A2, BRCA1, ESRRA, WT1, JUN, RELA, NFKB1, STAT3, NR3C1, NR2F6, CEBPB, CEBPD, ESR1, USF1	2	BRCA1, ESR1
TNFRSF10B	NO	16	SP1, ATM, STAT3, ELK1, GLI1, YY1, DDIT3, TP53, MYC, DNMT1, GLI2, RELA, HDAC9, NFKB1, ATF4, SIRT1	2	ATM, TP53
FOXM1	NO	7	SP1, ATM, FLI1, MYC, TP53, E2F1, FOXO3	2	ATM, TP53
FLT1	NO	8	EGR1, ATF1, CREB1, TP53, ESR1, EPAS1, E2F1, ETS1	2	ESR1, TP53
STAT3	NO	9	SOX3, FOXO1, HDAC1, TP53, TCF7L2, PIAS3, ZNF382, BRCA1, STAT1	2	BRCA1, TP53
HR	NO	2	RAD51, TP53	2	RAD51, TP53
DDB2	NO	7	SP1, TP63, TP53, NF1, BRCA1, E2F1, E2F3	2	BRCA1, TP53
DUSP1	NO	7	ATM, CREM, TP53, ATF2, PGR, E2F1, STAT6	2	ATM, TP53
MYC	NO	66	E2F4, LEF1, PGR, FOXM1, TBP, FUBP1, TP53, MYBL2, SMAD4, MXI1, MYB, AATF, ZNF382, FOS, ZBTB7A, SP1, E2F5, RBL1, TCF4, TBL1X, EP300, SMAD7, HDAC3, TCF3, SRSF1, SMAD3, CNBP, TLX1, ESR1, SIRT1, WT1, APC, CTNNB1, CEBPE, PRDM1, IFI16, DLX5, HDAC10, ZNF300, JUN, ETS2, RELA, BCL6, NFKB1, BRCA1, E2F1, STAT3, HDAC11, CEBPA, HOXA1, PTTG1, PPARG, YY1, MTA1, HDAC2, NF1, SNIP1, RUNX3, RB1, CTCF, ENO1, BDP1, AHR, STAT4, RFX1, HNF4A	3	BRCA1, ESR1, TP53
CYP1A1	NO	12	RELA, ARNT, VDR, NFKB1, KLF4, NFIC, RARA, ESR1, BRCA1, PPARA, AHR, USF1	2	BRCA1, ESR1
CDK4	NO	12	SP1, STAT3, SOX9, NR3C1, IRF1, RELA, TP53, SATB1, ESR1, MYC, NFKB1, SOX6	2	ESR1, TP53
EGFR	NO	30	AR, BCL3, WWP1, NR3C2, TFAP2A, PGR, NFKB2, SP1, EGR1, PML, HDAC3, MTA1, BRCA1, WT1, VDR, HOXB7, JUN, TP53, RELA, LRRFIP1, NFKB1, STAT1, STAT3, YY1, YBX1, ESR1, JUNB, PPARG, CREBBP, TSG101	4	BRCA1, ESR1, TP53, TSG101
TFF1	NO	17	HMGN1, NFATC3, ESR2, AIP, HDAC1, RELA, MTA1, MECP2, NELFB, JUN, FOXA2, ESR1, SP3, BRCA1, NFKB1, NCOA4, FOXA1	2	BRCA1, ESR1
BAX	NO	25	ATM, ING4, ERCC2, TP53, MYCN, PAX5, SP1, GFI1, PML, ABL1, AATF, MLLT10, ETS1, WWTR1, ELL, MLLT3, PER1, RELA, NFKB1, STAT1, TP63, NR3C1, ING1, TP73, HIF1A	2	ATM, TP53
MCL1	NO	12	ATM, STAT3, ELK1, RELA, ATF4, DDIT3, TP53, SRF, ELK4, E2F1, NFKB1, SIRT1	2	ATM, TP53
CCNA2	NO	14	SP1, CREM, RBL1, TP53, E4F1, SOX6, NFATC2, NR4A1, E2F3, ESR1, MYC, BCL6, ZBTB16, ZHX2	2	ESR1, TP53
FAS	NO	25	ATM, NFYA, TP53, ATF2, PURA, FOS, SP1, EGR1, GLI2, STAT1, GLI1, YBX1, HDAC1, NFYB, NFYC, JUN, TFAP2A, RELA, NFKB1, HDGF, STAT3, SREBF1, SREBF2, NFKBIA, YY1	2	ATM, TP53
RB1	NO	19	KAT2B, MYC, UHRF1, BDP1, RB1CC1, YY1, MYF6, RB1, HCFC1, MYOG, ID2, DNMT1, TP53, CTNNB1, MYOD1, DNMT3A, MYF5, E2F1, PAX5	2	RB1CC1, TP53
CCNB1	NO	15	MYC, FOXM1, E2F4, PTTG1, IRF1, KLF5, TP53, TFAP2A, RELA, KLF4, YBX1, BRCA1, NFKB1, E2F1, USF1	2	BRCA1, TP53
E2F1	NO	27	KAT2B, EIF2AK2, E2F7, POLR1A, PGR, SP1, NFKB1, YBX1, PAX8, NR2F2, E2F8, SIN3A, TRIM16, NR4A1, TP53, RELA, PARP1, PA2G4, E2F1, E2F6, NR0B2, IRF1, HES1, HCFC1, RB1, ESR1, TP73	2	ESR1, TP53
TYMS	NO	8	SP1, TFDP1, TP53, TFCP2, YBX1, ESR1, E2F1, USF1	2	ESR1, TP53
BCL2	NO	43	ATM, ING4, ERCC2, TBP, TP53, TWIST1, CREB1, MYB, SIM2, PGR, PAX5, SP1, CEBPA, ATF5, MSX2, NCOA3, GLI2, NR1I2, HOXA1, GLI1, TFAP2A, E2F1, DEK, WT1, ATF1, ING2, SATB1, PER1, ABL1, PARP1, NFKB1, MYC, DDB2, STAT3, BACH2, ZBTB16, RELA, ZNRD1, ESR1, PAWR, PPARG, IRF1, FOXA1	3	ATM, ESR1, TP53

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
TSG101	HMMR	No	1	THRSP
TSG101	ATM	No	8	DAXX, BCAS3, MDM2, BAG6, TP53, MTA3, HNRNPUL1, TFF1
TSG101	NQO2	No	2	NXF1, MOV10
TSG101	AKT1	No	15	NF2, IQGAP1, MDM2, VCP, DNAJB1, CDKN1A, FASN, RASL10B, NEDD4, AR, YBX1, THRSP, EP300, MTA3, TFF1
TSG101	XRCC3	No	7	SCGB3A1, BCAS3, XPO1, SCAMP3, TNKS1BP1, TRIM25, TFF1
TSG101	RB1CC1	No	4	UBC, THRSP, RNF111, TP53
TSG101	PPM1D	No	2	UBC, MDM2
TSG101	RAD54L	No	1	BAG6
TSG101	FAM175A	No	1	UBC
TSG101	NBN	No	3	EP300, RAD18, MDM2
TSG101	CDH1	No	5	NDRG1, ACTN4, IQGAP1, EP300, MDM2
TSG101	CHEK2	No	5	TP53, DAPK3, MDM2, AATF, VCP
TSG101	BRCA1	No	13	AR, VCP, PABPC1, RAD18, DNAJB1, TP53, TRIM74, JUN, TRIM46, UBC, YBX1, UBE2I, EP300
TSG101	BRCA2	No	3	VPS28, NEDD4, TP53
TSG101	BARD1	No	10	LARP1, SMCHD1, WDR5, WDR26, TP53, EWSR1, YBX1, FAM9B, HNRNPUL1, MOV10
TSG101	KRAS	No	2	THRSP, BCAS3
TSG101	TP53	Yes	25	VASP, PABPC1, DAXX, DAPK3, EWSR1, BCR, IQGAP1, VCP, THRB, DNAJB1, CEP55, CDKN1A, MDM2, TP53, EP300, MOV10, CHMP4B, NR3C1, WDR5, STK11, YBX1, UBC, UBE2I, PDLIM7, TSG101
TSG101	ESR1	No	21	ARFGAP2, CDKN1A, BCAS3, VCP, PABPC1, KLK5, EP300, CAPRIN1, WDR5, UPF1, SFPQ, TP53, JUN, MDM2, XPO1, NONO, EWSR1, YBX1, UBE2I, ACTN4, TRIM25
TSG101	PHB	No	9	NF2, AR, BCAS3, VCP, ADRB2, TP53, UBC, XPO1, NTRK1
TSG101	PALB2	No	4	THRSP, BCAS3, MOV10, KLK6
TSG101	CASP8	No	6	KLK5, BIRC2, YBX1, PRSS50, TP53, UBC
TSG101	RAD51	No	5	UBE2I, TFF1, RAD18, NXF1, TP53
TSG101	PIK3CA	No	4	NTRK1, THRSP, WDR5, GRB2
HMMR	ATM	No	3	BRCA1, IL24, NAT2
HMMR	AKT1	No	8	IL24, CALM1, LRRK2, TBK1, DCTN1, ACTB, BRCA1, THRSP
HMMR	BRIP1	No	1	BRCA1
HMMR	XRCC3	No	2	ITIH5, GREB1
HMMR	RB1CC1	No	5	THRSP, ITIH5, TBK1, IL24, GREB1
HMMR	PPM1D	No	2	ITIH5, NAT2
HMMR	FAM175A	No	1	BRCA1
HMMR	NBN	No	3	BRCA1, BACH1, NAT2
HMMR	CHEK2	No	5	BRCA1, IL24, MAPK1, ITIH5, CDH13
HMMR	BRCA1	Yes	6	BACH1, MAPK1, ITIH5, AURKA, TPX2, BRCA1
HMMR	BRCA2	No	2	BRCA1, BACH1
HMMR	BARD1	No	4	AURKA, BRCA1, MAPK1, BACH1
HMMR	KRAS	No	4	CALM1, IL24, MAPK1, THRSP
HMMR	TP53	No	11	SPICE1, CSNK1E, BACH1, AURKA, NIN, MAPK1, TUBB2A, CSNK1A1, ACTB, BRCA1, STX5
HMMR	ESR1	No	6	CALM1, TBK1, MAPK1, SVIL, ACTB, BRCA1
HMMR	PHB	No	2	ACTB, TMEM63B
HMMR	PALB2	No	6	IL24, GREB1, BACH1, NAT2, THRSP, BRCA1
HMMR	CASP8	No	5	IL24, LRRK2, MAPK1, GREB1, CDH13
HMMR	RAD51	No	5	ITIH5, BRCA1, IL24, CDH13, NAT2
HMMR	PIK3CA	No	2	IL24, THRSP
ATM	AKT1	No	25	MDM2, MAPK14, IKBKG, MTA3, SKP2, FOXO3, SMAD7, CREB1, WHSC1L1, PPP1CC, TOPBP1, SMARCB1, PRKDC, TRAF6, OSGIN1, NR4A1, TCL1A, BRCA1, TFF1, IL24, HSPA8, PPP1CA, PPP2R4, EIF4EBP1, BCL10
ATM	BRIP1	No	5	BRCA1, TOPBP1, BLM, RPA1, MLH1
ATM	XRCC3	No	7	BRCA2, CDK9, OSGIN1, TFF1, BCAS3, RNF20, RAD51
ATM	RB1CC1	No	11	VHL, IL24, RNF20, ERRFI1, HUWE1, RPA1, TP53, RPA2, DYRK2, SMARCB1, WHSC1L1
ATM	PPM1D	No	6	MDM2, ERRFI1, OSGIN1, NAT2, H2AFX, WHSC1L1
ATM	RAD54L	No	1	BAG6
ATM	FAM175A	No	3	PARP1, BRCA1, MDC1
ATM	NBN	Yes	33	ATM, ATRIP, MDM2, FANCD2, KAT5, MDC1, RAD50, RFC1, BMI1, MSH6, SKP2, DCLRE1C, ATR, MSH2, RPA1, MCPH1, RBBP8, RPA2, SNW1, BRCA1, DDX1, TOPBP1, TERF1, MRE11A, PRKDC, TERF2, ATF2, NAT2, H2AFX, WRN, BLM, MLH1, XRCC5
ATM	CDH1	No	10	HSPA8, XRCC5, MDM2, HDAC1, SMAD7, PPP1CA, SKP2, E2F1, RAD17, GMNN
ATM	CHEK2	Yes	20	ATM, VHL, ATR, BRCA2, MDM2, MSH2, PRKDC, IL24, ELAVL1, TP53BP1, TP53, MDC1, RAD50, TRIM28, PER3, NR4A1, BRCA1, RNF20, CHEK2, WHSC1L1
ATM	BRCA1	Yes	49	ATM, ATRIP, RELA, CHEK1, FANCD2, SMARCB1, TOPBP1, SMC3, CSNK1D, RAD51, RFC1, PEX5, KAT5, H2AFX, SKP2, DCLRE1C, ATR, MLH1, BRAT1, POLR2A, RPA1, CDK9, RBBP8, FOXO3, MRE11A, NBN, SMC1A, TERF1, HDAC1, PRKDC, TERF2, TP53, MDC1, ABL1, PARP1, HSPA8, MSH6, BRCA1, E2F1, BRCA2, HUWE1, TP53BP1, PPP1CA, BLM, HIF1A, RAD50, CHEK2, MSH2, XRCC5
ATM	BRCA2	Yes	11	ATM, ATR, TP53, SMC3, MCPH1, RPA1, CHEK2, BRCA1, H2AFX, RAD51, FANCD2
ATM	BARD1	No	26	MDC1, TOPBP1, HNRNPUL1, RAD50, KAT5, MSH6, SKP2, MSH2, CDK9, RBBP8, BRCA1, TOP1, NBN, SMC1A, MRE11A, ELAVL1, TP53, RELA, PARP1, H2AFX, BRCA2, AP1B1, POLR2A, RAD51, MLH1, XRCC5
ATM	KRAS	No	5	TRAF6, OSGIN1, BCAS3, IL24, ELAVL1
ATM	TP53	Yes	58	ATM, WWOX, RELA, MDM2, H2AFX, CHEK1, TP53, KAT5, DAXX, MDC1, RFC1, CSNK1D, CREB1, RPA1, BMI1, RNF20, MSH6, ATR, FOXO3, MSH2, BRCA1, SMAD7, SIRT7, SOCS1, E4F1, RPA2, SNW1, MAPK14, VPRBP, SMARCB1, TOP1, VHL, SPSB1, PPP1CA, HDAC1, PRKDC, CDKN2C, ELAVL1, MED1, NR4A1, TRIM28, ABL1, PARP1, HSPA8, XPC, BANP, CHEK2, PPP1CC, BRCA2, WRN, HUWE1, TP53BP1, KAT8, BLM, RAD51, RRM2B, HIF1A, TAF1
ATM	ESR1	No	32	MDM2, TOPBP1, SMC3, RAD50, PPP1CA, KAT5, SKP2, MSH2, RAD51, BRCA1, DDX1, HDAC1, TOP1, SMC1A, BCAS3, CHD4, PRKDC, TRAF6, MED1, TP53, RELA, PARP1, H2AFX, PPP1CC, WHSC1L1, E2F1, HSPA8, RNF40, SPOP, POLR2A, HIF1A, XRCC5
ATM	PHB	No	8	BCAS3, HDAC1, HUWE1, TP53, ATF2, PARP1, E2F1, SKP2
ATM	PALB2	No	9	IL24, BRCA2, ERRFI1, ALB, RBBP8, NAT2, BCAS3, BRCA1, RAD51
ATM	CASP8	No	8	IL24, ERRFI1, TRAF6, BLM, TP53, PARP1, GMNN, WHSC1L1
ATM	RAD51	Yes	20	ATM, IL24, BRCA2, ABL1, WRN, H2AFX, MSH2, RPA1, CHEK1, BLM, TP53, MDC1, MCPH1, WHSC1L1, TFF1, NAT2, MSH6, BRCA1, RAD51, FANCD2
ATM	PIK3CA	No	3	HDAC1, ATR, IL24
NQO2	BARD1	No	1	MOV10
NQO2	TP53	No	2	COPS5, MOV10
NQO2	ESR1	No	1	COPS5
NQO2	PALB2	No	1	MOV10
NQO2	RAD51	No	1	NXF1
AKT1	BRIP1	No	2	BRCA1, TOPBP1
AKT1	XRCC3	No	11	FKBP5, IMPDH2, SNAI1, MRC2, SERPINB5, OSGIN1, PHB2, HSP90AB1, NCOA4, APP, TFF1
AKT1	RB1CC1	No	12	IL13RA2, IL24, PINK1, SMARCB1, MAP3K5, SKI, EPSTI1, WHSC1L1, CTNNB1, THRSP, TBK1, MRC2
AKT1	PPM1D	No	5	MRC2, EPSTI1, OSGIN1, MDM2, WHSC1L1
AKT1	FAM175A	No	2	BRCA1, HSPA4
AKT1	NBN	No	14	TOPBP1, MDM2, CASC3, HSPA4, RICTOR, SNAI1, MTOR, TERF2IP, SIRT1, MAPKAP1, PRKDC, BRCA1, EP300, SKP2
AKT1	CDH1	No	17	HSPA9, HSPA8, CTNNB1, MDM2, ILK, EP300, CREBBP, SMAD7, IQGAP1, PPP1CA, PTEN, HSP90AA1, EGFR, SRC, HSPA5, GSK3B, SKP2
AKT1	CHEK2	No	14	KAT2B, IL24, WHSC1L1, MDM2, VCP, PRKDC, PPP2CA, ENO1, NR4A1, APP, ST14, PPP2R1A, BRCA1, SIRT1
AKT1	BRCA1	Yes	42	AR, PIAS1, VCP, PPP2CA, EZH2, PPP1CA, CTBP1, SKP2, COMMD1, YBX1, ITPR1, SMARCC2, NPM1, DNAJB1, SMAD3, CTNNB1, DNMT1, FOXO3, YWHAZ, TOPBP1, ESR1, SMARCB1, PRKDC, HSP90AA1, NFE2L2, PPP1CB, AKT1, EP300, BRCA1, SMARCC1, CREBBP, FANCA, HSPA8, RICTOR, XIAP, MTOR, TUBB, CLK2, ENO1, MAPKAP1, CSNK2A1, PHB2
AKT1	BRCA2	No	5	KAT2B, BRCA1, SMAD3, SMAD2, NEDD4
AKT1	BARD1	No	12	CCDC88A, TOPBP1, PIAS1, ZHX1, COMMD1, NPM1, SETDB1, YWHAZ, ESR1, YBX1, BRCA1, SKP2
AKT1	KRAS	No	10	IL24, CALM1, SERPINB5, PIK3CA, OSGIN1, TRAF6, RAF1, SORBS3, THRSP, APP
AKT1	TP53	No	74	KAT2B, BCL2L1, PIAS1, ZHX1, VCP, PSMC5, YWHAE, DDX5, SRC, CREB1, VIM, APOH, HSP90AB1, HSPA5, CTBP1, STUB1, IQGAP1, TNK2, MDM2, TUBB, MAPK8, YBX1, GSK3B, MDH1, BRCA1, SMAD7, STK4, SKI, DNAJB1, SMAD3, DAB2IP, TBC1D4, DNMT1, MAPK14, APPL1, ALYREF, YWHAZ, HSPA9, SFN, PIAS2, GAPDH, PRKDC, SMARCB1, MAPK9, CLTC, SMAD2, IKBKB, MUL1, NR4A1, HSP90AA1, PTEN, NPM1, PPP2R1A, PPP3CA, EP300, FOXO3, KAT6A, SMARCC1, CREBBP, PPP1CC, HSPA8, SNAI1, CSNK2A1, HSPA4, ACTB, MTOR, CDKN1A, PPP1CA, CHUK, HSPB1, SIRT1, ESR1, TPM4, UCHL1
AKT1	ESR1	Yes	71	DDX5, PIAS1, PTEN, VCP, PRKCZ, PSMC5, TOPBP1, ESR1, FHL1, SRC, EZH2, NSF, EGFR, GNB1, SERPINB5, SFN, PAK1, SKP2, HSP90AA1, CLTC, TSC2, TUBB, KAT6A, YBX1, PA2G4, PPP2CA, MAPKAPK2, SKI, NCOR2, HDAC3, MDM2, SMAD3, STUB1, FOXO1, FOXO4, BRCA1, ALYREF, SIRT1, EPSTI1, CDKN1A, CALM1, CTNNB1, PIAS2, GAPDH, KRT10, PRKDC, SMAD2, ACTB, TRAF6, AKT1, NPM1, PPP2R1A, NCOA4, EP300, PPP1CC, WHSC1L1, FKBP5, PPIA, HSPA8, TBK1, HSPA4, IRS1, PPP1CA, CHUK, HSPB1, TCOF1, TSC1, PIK3CA, EIF4A1, CREBBP, PHB2
AKT1	PHB	No	16	NF2, AR, HSP90AB1, VCP, CASC3, SKP2, YWHAE, CLTC, NPM1, ACTB, RAF1, YWHAZ, ESR1, ATP1A1, PHB2, ST14
AKT1	PALB2	No	8	IL13RA2, IL24, SNAI1, HIST2H2BE, SERPINB5, BRCA1, THRSP, MRC2
AKT1	CASP8	No	19	IL13RA2, S100A14, AGR3, IL24, WHSC1L1, PTEN, LRRK2, MAPK8, SERPINB5, XIAP, CHUK, IKBKB, TRAF6, EPSTI1, VIM, YBX1, ST14, CLIP3, CASC3
AKT1	RAD51	No	9	IL24, ST14, HSP90AA1, TERF2IP, VIM, TFF1, ESR1, BRCA1, WHSC1L1
AKT1	PIK3CA	Yes	12	IL13RA2, IL24, AKT1, NOTCH1, IRS1, DDX5, ERBB3, SMAD2, ESR1, SMAD3, THRSP, APPL1
BRIP1	XRCC3	No	2	PMS2, MMS19
BRIP1	RB1CC1	No	2	VAPB, RPA1
BRIP1	FAM175A	No	2	BRCA1, BARD1
BRIP1	NBN	No	6	TOPBP1, MLH1, BARD1, RPA1, BLM, BRCA1
BRIP1	CDH1	No	1	LMNA
BRIP1	CHEK2	No	1	BRCA1
BRIP1	BRCA1	Yes	9	HNRNPC, TOPBP1, MLH1, BARD1, PMS2, RPA1, BLM, USP37, BRCA1
BRIP1	BRCA2	No	6	HNRNPC, BARD1, PMS2, RPA1, PMS1, BRCA1
BRIP1	BARD1	Yes	5	BARD1, BRCA1, TOPBP1, HNRNPC, MLH1
BRIP1	KRAS	No	1	HNRNPC
BRIP1	TP53	No	5	BRCA1, RPA1, BARD1, BLM, LMNA
BRIP1	ESR1	No	5	BARD1, BRCA1, TOPBP1, HNRNPC, MMS19
BRIP1	PHB	No	1	LMNA
BRIP1	PALB2	No	2	BRCA1, HNRNPC
BRIP1	CASP8	No	1	BLM
BRIP1	RAD51	No	5	HNRNPC, BRCA1, BARD1, BLM, RPA1
XRCC3	RB1CC1	No	6	ITIH5, MRC2, GREB1, PSMC3IP, RNF20, BAP1
XRCC3	PPM1D	No	3	OSGIN1, ITIH5, MRC2
XRCC3	FAM175A	No	1	FANCG
XRCC3	NBN	No	2	SNAI1, BAP1
XRCC3	CDH1	No	1	HSPD1
XRCC3	CHEK2	No	7	UBR5, BRCA2, ITIH5, FAM84B, PSMC3IP, RNF20, APP
XRCC3	BRCA1	No	16	HNRNPA2B1, PMS2, BRCA2, COPE, SSX2IP, BAP1, GPN1, ZC3H11A, DNAJA1, EIF5B, RAD51, HSPD1, MED17, ITIH5, PHB2, CDK9
XRCC3	BRCA2	Yes	3	PMS2, RAD51, FANCG
XRCC3	BARD1	No	9	CCAR1, UBR5, MED17, SNRNP70, NSRP1, CDK9, BRCA2, RBM17, RAD51
XRCC3	KRAS	No	4	OSGIN1, BCAS3, SERPINB5, APP
XRCC3	TP53	No	21	CCAR1, UBR5, TCP1, BRCA2, HSP90B1, UBR4, SNAI1, CKAP4, SF3B2, ATP5A1, SSX2IP, HNRNPA2B1, CCT8, RAD51, DNAJA1, HSP90AB1, MED17, RNF20, EIF5B, CCT3, CCT6A
XRCC3	ESR1	No	25	MED24, XPO1, MED16, MED17, SF3B1, PSMC3IP, HSP90B1, RPL10, HNRNPA2B1, FARSA, UNC45A, BCAS3, BAP1, SERPINB5, TECR, HSPD1, NCOA4, MMS19, FKBP5, CXCL1, GCN1L1, NCAPD3, RAD51, TRIM25, PHB2
XRCC3	PHB	No	7	BCAS3, UQCRQ, TMPO, SSR3, XPO1, HSP90AB1, PHB2
XRCC3	PALB2	No	8	BRCA2, SERPINB5, SNAI1, FAM84B, MRC2, GREB1, BCAS3, RAD51
XRCC3	CASP8	No	4	PSMC3IP, BAP1, SERPINB5, GREB1
XRCC3	RAD51	Yes	9	BRCA2, TIMM13, ITIH5, FAM84B, HNRNPA2B1, RAD51, SWSAP1, RAD51C, TFF1
XRCC3	PIK3CA	No	1	PSMC3IP
RB1CC1	PPM1D	No	8	ERRFI1, GLCE, UBC, EPSTI1, MRC2, LYPD3, ITIH5, WHSC1L1
RB1CC1	RAD54L	No	1	SGTB
RB1CC1	FAM175A	No	1	UBC
RB1CC1	NBN	No	3	RPA1, BAP1, RPA2
RB1CC1	CDH1	No	1	CTNNB1
RB1CC1	CHEK2	No	8	VHL, IL24, ITIH5, TP53, LYPD3, PSMC3IP, RNF20, WHSC1L1
RB1CC1	BRCA1	No	9	PRKAA2, SMARCB1, HUWE1, RPA1, TP53, CTNNB1, UBC, ITIH5, BAP1
RB1CC1	BRCA2	No	2	TP53, RPA1
RB1CC1	BARD1	No	4	MOB4, TACC1, TP53, ERCC6L
RB1CC1	KRAS	No	3	IL24, THRSP, EEA1
RB1CC1	TP53	Yes	15	VHL, RPA2, PTK2, SAFB2, SMARCB1, RPA1, HUWE1, SAFB, CCDC8, TP53, RFWD2, SKI, UBC, TCEAL4, RNF20
RB1CC1	ESR1	No	14	HBP1, RBMX, TBK1, BAP1, SAFB2, GLCE, SAFB, SKI, SKIL, EPSTI1, TP53, CTNNB1, PSMC3IP, WHSC1L1
RB1CC1	PHB	No	4	UBC, HUWE1, TP53, CCDC8
RB1CC1	PALB2	No	7	IL13RA2, IL24, ERRFI1, GREB1, LYPD3, THRSP, MRC2
RB1CC1	CASP8	No	17	IL13RA2, EPSTI1, BLID, GREB1, ERRFI1, LYPD3, HBP1, TP53, UBC, GLCE, BAP1, UMPS, TRAF2, PSMC3IP, VPS45, IL24, WHSC1L1
RB1CC1	RAD51	No	7	IL24, ITIH5, RPA1, TP53, UMPS, SGOL1, WHSC1L1
RB1CC1	PIK3CA	No	5	IL13RA2, THRSP, PSMC3IP, IL24, UMPS
PPM1D	FAM175A	No	1	UBC
PPM1D	NBN	No	4	H2AFX, MDM2, CDC5L, NAT2
PPM1D	CDH1	No	1	MDM2
PPM1D	CHEK2	No	6	MDM2, ITIH5, DIRAS3, LYPD3, RHOBTB2, WHSC1L1
PPM1D	BRCA1	No	5	KDM1A, UBC, H2AFX, RAD21, ITIH5
PPM1D	BRCA2	No	2	H2AFX, RAD21
PPM1D	BARD1	No	1	H2AFX
PPM1D	KRAS	No	2	OSGIN1, DIRAS3
PPM1D	TP53	No	4	KDM1A, UBC, H2AFX, MDM2
PPM1D	ESR1	No	6	KDM1A, MDM2, EPSTI1, GLCE, H2AFX, WHSC1L1
PPM1D	PHB	No	1	UBC
PPM1D	PALB2	No	7	CASZ1, ERRFI1, DIRAS3, NAT2, LYPD3, RHOBTB2, MRC2
PPM1D	CASP8	No	6	ERRFI1, EPSTI1, UBC, GLCE, LYPD3, WHSC1L1
PPM1D	RAD51	No	4	H2AFX, ITIH5, WHSC1L1, NAT2
PPM1D	PIK3CA	No	1	BEX2
RAD54L	TP53	No	1	HECW2
FAM175A	NBN	No	6	BARD1, HSPA4, PAXIP1, MDC1, BRCA1, SUMO2
FAM175A	CHEK2	No	2	BRCA1, MDC1
FAM175A	BRCA1	Yes	10	BRE, BABAM1, BARD1, MDC1, UBC, UIMC1, PARP1, BRCA1, SUMO2, BRCC3
FAM175A	BRCA2	No	5	BRCC3, BRCA1, BARD1, BRE, FANCG
FAM175A	BARD1	Yes	7	BRE, BARD1, MDC1, UIMC1, PARP1, BRCA1, BRCC3
FAM175A	TP53	No	9	BRE, HSPA4, BARD1, MDC1, UBC, UIMC1, PARP1, BRCA1, BRCC3
FAM175A	ESR1	No	5	PARP1, HSPA4, BRCA1, BARD1, UIMC1
FAM175A	PHB	No	3	PARP1, UBC, BRE
FAM175A	PALB2	No	1	BRCA1
FAM175A	CASP8	No	2	PARP1, UBC
FAM175A	RAD51	No	5	BRCC3, BRCA1, BARD1, BRE, MDC1
NBN	CDH1	No	4	SKP2, EP300, MDM2, XRCC5
NBN	CHEK2	No	11	ATM, ATR, MDM2, MSH2, PRKDC, MDC1, MDM4, RAD50, RNF8, BRCA1, SIRT1
NBN	BRCA1	Yes	38	ATM, ATRIP, FANCD2, TERF1, MDC1, RAD50, RFC1, RECQL5, KAT5, H2AFX, SKP2, DCLRE1C, ATR, CCNE1, BACH1, EP300, MSH2, RPA1, RBBP8, TUBG1, BRCA1, BAP1, TOPBP1, RAD18, MRE11A, PRKDC, TERF2, BARD1, MSH6, SUMO2, UBE2D1, RICTOR, MTOR, BLM, UBE2N, MAPKAP1, MLH1, XRCC5
NBN	BRCA2	No	9	ATM, ATR, BACH1, FANCD2, BARD1, RPA1, MCPH1, BRCA1, H2AFX
NBN	BARD1	Yes	18	MSH6, TOPBP1, BACH1, KAT5, UBE2D1, H2AFX, UBE2N, MSH2, BARD1, MDC1, HIST1H3A, RBBP8, XRCC5, RAD50, BRCA1, MRE11A, SKP2, MLH1
NBN	KRAS	No	1	MED4
NBN	TP53	No	34	ATM, MDM2, H2AFX, SNAI1, MDC1, RPA1, BMI1, SNW1, TUBG1, ATR, BACH1, UBE2B, MSH2, RFC1, OFD1, RPA2, BRCA1, SIRT1, BARD1, KAT5, PRKDC, MSH6, EP300, CELA2B, WRN, HSPA4, UBE2N, MTOR, BLM, MDM4, NCL, ATRX, UBE2A, VRK1
NBN	ESR1	No	18	TOPBP1, KAT5, MDM2, EP300, HSPA4, MSH2, BAP1, BARD1, XRCC5, RAD50, SIRT1, TUBG1, NCL, PRKDC, BRCA1, DDX1, H2AFX, SKP2
NBN	PHB	No	3	ATF2, SKP2, CASC3
NBN	PALB2	No	6	BACH1, SNAI1, RBBP8, NAT2, BRCA1, HIST1H3A
NBN	CASP8	No	3	BLM, BAP1, CASC3
NBN	RAD51	No	19	ATM, FANCD2, ATRX, WRN, RAD18, MSH2, BARD1, BLM, RECQL5, MSH6, TERF2IP, MDC1, MCPH1, RPA1, NAT2, RPA3, BRCA1, H2AFX, TUBG1
NBN	PIK3CA	No	1	ATR
CDH1	CHEK2	No	1	MDM2
CDH1	BRCA1	No	17	XRCC5, HSPA8, CTNNB1, EZR, HDAC2, HDAC1, ACTG1, CREBBP, PPP1CA, JUP, HSP90AA1, CCNB1, HSPD1, POLR2E, EP300, E2F1, SKP2
CDH1	BARD1	No	3	POLR2E, SKP2, XRCC5
CDH1	TP53	No	23	MDM2, CRYAB, CDC42, HSPA5, IQGAP1, MYO6, EP300, SMAD7, LMNA, HSPA9, HDAC1, HSP90AA1, SET, RNF2, PTEN, SRC, GSK3B, HSPA8, PTTG1, CREBBP, HDAC2, PPP1CA, ECT2
CDH1	ESR1	No	28	PTEN, MDM2, HSPD1, KRT8, EGFR, ACTN4, SKP2, MYO6, CBLL1, CTNNB1, E2F1, HDAC1, ACTN1, KRT1, KRT18, HSP90AA1, JUP, SET, AP2M1, SRC, EP300, ANP32B, HSPA8, CREBBP, HDAC2, PPP1CA, POLR2E, XRCC5
CDH1	PHB	No	7	ACTN1, HDAC1, RNF2, LMNA, C1QBP, E2F1, SKP2
CDH1	CASP8	No	5	CASP3, CRYAB, PTEN, GMNN, EZR
CDH1	RAD51	No	3	CASP3, CDC42, HSP90AA1
CDH1	PIK3CA	No	1	HDAC1
CHEK2	BRCA1	Yes	22	ATM, VCP, MAPK1, ITIH5, TP53, RAD50, PLK1, ATR, MSH2, BRCA1, PPP2R5C, ENO1, PRKDC, MDC1, PPP2CA, BRCA2, MAPK3, TP53BP1, KPNA2, RB1, CHEK2, CCAR2
CHEK2	BRCA2	Yes	7	ATM, KAT2B, ATR, PLK1, TP53, BRCA1, CHEK2
CHEK2	BARD1	No	13	UBR5, BRCA2, SRPK1, FOXK2, MSH2, STRAP, MAPK1, MDC1, TP53, RAD50, ELAVL1, SRPK2, BRCA1
CHEK2	KRAS	No	7	IL24, CCL5, PML, MAPK1, ELAVL1, DIRAS3, APP
CHEK2	TP53	Yes	36	ATM, KAT2B, MDC1, VCP, SRPK1, MAPK3, TP53, DAPK3, TP53BP1, RNF20, ATR, MDM2, MSH2, RCHY1, BRCA1, PPP2R5C, SIRT1, VHL, CUL4A, PRKDC, FOXK2, ELAVL1, NR4A1, TRIM28, PPP2R1A, PSME3, FOXK1, UBR5, BRCA2, PLK3, MAPK1, PLK1, RB1, CHEK2, PML, MDM4
CHEK2	ESR1	No	21	KLK9, SRPK2, VCP, PRMT2, SRPK1, PRKDC, MSH2, FOXK2, MAPK1, TP53, CUL1, POLR2L, MDM2, RAD50, WHSC1L1, PPP2CA, PPP2R1A, BRCA1, FOS, PSMC3IP, SIRT1
CHEK2	PHB	No	6	RAB11A, VCP, CCL5, TP53, RB1, ST14
CHEK2	PALB2	No	9	IL24, BRCA2, CCL5, PRDM14, FAM84B, DIRAS3, LYPD3, BRCA1, RHOBTB2
CHEK2	CASP8	No	12	IL24, ST14, PRDM14, MAPK1, KLK9, TP53, RB1, WHSC1L1, CDH13, LYPD3, PSMC3IP, BEX1
CHEK2	RAD51	No	13	ATM, IL24, BRCA2, ST14, ITIH5, MSH2, TP53, MDC1, FAM84B, CDH13, BRCA1, PML, WHSC1L1
CHEK2	PIK3CA	No	4	BEX1, PSMC3IP, ATR, IL24
BRCA1	BRCA2	Yes	29	ATM, BRE, FANCD2, SHFM1, H2AFX, CCNA2, SP1, ATR, BACH1, RPA1, STAT5A, SMAD3, BRCA1, RAD21, PALB2, MORF4L1, BARD1, PMS2, TP53, PCNA, SMC3, CHEK2, BRCC3, HNRNPC, CDK2, FLNA, PLK1, POLH, RAD51
BRCA1	BARD1	Yes	95	PIAS1, HSPA14, UBE2K, BRE, TP53, SNRNP200, PGAM5, COMMD1, MSH2, CDKN2AIP, SNX3, SMC1A, UBXN1, MRE11A, UBE2N, DRG1, CNTN4, MDC1, RELA, RFC2, UBE3A, BRCA2, UBE2D1, SUPT5H, POLR2A, HIST1H2BG, ESR1, RNGTT, RAD51, PARG, GTF3C4, ATP1B3, POLR2H, ASH2L, SKP2, BACH1, PCBP2, HIST2H2AC, UBE2E1, PSMA7, CBX1, AURKA, BRD7, ND1, ATP1B1, FAM175A, PIAS4, KAT5, H2AFX, UBE2W, OLA1, CRIPAK, RBBP8, BRCA1, CSTF1, TOPBP1, MED17, MSH3, NPC2, UIMC1, COL1A1, TULP2, CBX5, CDK2, XRCC6, XIST, CSTF2, XRCC5, CDK1, UBE2E3, RAD50, CBX3, LGALS3, UBE2E2, UBE2D2, TCEB3, MLH1, NPM1, SRSF1, YWHAZ, CDK9, NBN, BARD1, UBE2D3, MTA2, PARP1, MSH6, BRIP1, POLR2E, BRCC3, HNRNPC, MAPK1, YBX1, FBXO5, FBXO44
BRCA1	KRAS	No	4	HNRNPC, MAPK1, DNAJA3, BCL2
BRCA1	TP53	Yes	145	PIAS1, RELA, UBE2K, TFAP4, SUPT6H, RPL28, DDB1, TRIM24, PCNA, PABPC1, UBE3A, MAP3K1, NCOA3, CSNK2B, RPA1, CDK8, FOXO3, SMARCC1, RPL21, BARD1, USP7, NCOA1, TP53, ABL1, GTF2I, GNL3L, BRCA2, CDK2, SKP1, FLNA, MAPK3, PIAS4, PLK1, BLM, ESR1, RAD51, ATM, MYC, NFYA, HNRNPA1, ERCC6, XRCC6, TFAP2C, MTOR, EBNA1BP2, ASH2L, KAT5, TUBG1, SP1, PRMT1, BACH1, RFC1, DNAJB1, NCOA2, NABP2, RPS27, RPS13, CDKN2A, VCP, HERC2, REV1, HSP90AA1, H2AFX, DNAJA1, AURKA, HDAC2, BRD7, MED21, UBC, RPL31, CHEK2, RBBP4, MSH2, HIF1A, BRE, RPS7, CDK1, MDC1, CSNK1D, HECTD3, MSH6, CCNA2, KDM1A, HNRNPA2B1, SUMO1, RBBP7, SMARCD2, SMAD3, ETS1, BRCA1, MED17, PPP1CA, HDAC1, PRKDC, CAPZB, EIF5B, EP300, SMARCA4, RPL3, TP53BP1, WDR48, TP63, CSNK2A1, CHEK1, GTF2H4, TPM3, RB1, RFC4, MNAT1, TPM1, HUWE1, SSX2IP, TFAP2A, YBX1, CDK7, CTBP1, ATR, BCL2, UIMC1, NPM1, SRSF1, DNMT1, PPP2R5C, SMARCB1, YWHAZ, VDR, UBE2N, IFI16, SMARCA5, TOP2A, MTA2, PARP1, RANBP9, TP73, BRCC3, GTF3C4, HSPA8, CREBBP, MAPK1, NINL, CCNH, TUBB, UBE2I, RPRD1A, PPP1R13B
BRCA1	ESR1	Yes	126	PIAS1, AKT1, SMC3, RPL28, NPM1, TRIM24, PGAM5, VCP, MSH2, NCOA3, POLR2D, CDK8, DHX9, RPL3, CTNNB1, BAP1, MKI67, SMC1A, RPL21, SUPT6H, BARD1, JUN, NCOA1, TP53, RELA, UBE3A, SKP1, FLNA, POLR2I, POLR2A, HIST1H2BG, ESR1, POLR2G, RAD51, MYC, HNRNPD, HNRNPA1, PGR, NOP2, NUMA1, EZH2, POLR2H, ASH2L, SKP2, SP1, PRMT1, SNX6, PIK3R1, NCOA2, HIST2H2AC, RPS13, SUZ12, HSP90AA1, SUPT16H, RUVBL2, HSPD1, H2AFX, AHR, HDAC2, TUBB, MED21, PHB2, RBBP4, HIF1A, PABPC1, NFYA, POLR2J, NRIP1, KAT5, KDM1A, POU2F1, RDX, CCND1, STAT5A, RBBP7, HNRNPA2B1, POLR2C, SMAD3, YBX1, BRCA1, TOPBP1, MED17, HDAC1, PRKDC, CAPZB, UIMC1, EP300, SMARCA4, FHL2, SMARCA2, CDK2, XRCC6, CEBPB, RSL1D1, MNAT1, XRCC5, PPP2CA, RAD50, CCNH, DDX54, CDK7, FLII, RPSA, SRSF1, TUBG1, NUP153, E2F1, EIF4G1, LMO4, NELFB, JUP, TOP2A, MTA2, PARP1, NAT10, RANBP9, CRIPAK, UBE2I, HNRNPC, HSPA8, RBM28, CREBBP, MAPK1, GNB2L1, PPP1CA, POLR2E
BRCA1	PHB	No	23	AR, VCP, BRE, SUZ12, SKP2, OLA1, NPM1, E2F1, YWHAZ, ESR1, RBL1, EED, HDAC1, TP53, PARP1, SMARCA2, CDK2, HUWE1, RB1, SMARCA4, UBC, RBL2, PHB2
BRCA1	PALB2	Yes	12	HNRNPC, BRCA2, BACH1, MORF4L1, USP2, MORF4L2, HIST1H2BG, POLH, RBBP8, BRCA1, PALB2, RAD51
BRCA1	CASP8	No	17	BCL2, UBC, USP2, XIAP, MAPK1, BLM, TP53, CEBPB, MSN, RB1, CASP9, YBX1, MAP3K14, PARP1, HECTD3, EZR, BAP1
BRCA1	RAD51	Yes	34	ATM, BRE, PCNA, FANCD2, MDC1, RECQL5, H2AFX, TUBG1, SP1, SUMO1, MSH2, RPA1, HNRNPA2B1, CSNK2B, DNAJA3, BRCA1, ITIH5, BARD1, MORF4L1, RAD18, HSP90AA1, TP53, ABL1, MSH6, UBE2I, BRCC3, HNRNPC, BRCA2, CHEK1, PALB2, BLM, ESR1, NELFB, RAD51
BRCA1	PIK3CA	No	8	ATR, ESR1, LCK, HDAC1, PIK3R1, SMAD3, AKT1, STAT1
BRCA2	BARD1	Yes	12	BRE, CDK2, BACH1, H2AFX, BCCIP, BARD1, HNRNPC, TP53, RAD51, BRCA1, AURKB, BRCC3
BRCA2	KRAS	No	1	HNRNPC
BRCA2	TP53	Yes	26	KAT2B, ATM, BRE, TP53, AURKB, CCNA2, SP1, ATR, BACH1, RAD23A, PSMD6, RPA1, SMAD3, BRCA1, BARD1, SMAD2, PCNA, H2AFX, BRCC3, CDK2, FLNA, USP11, PLK1, SERPINH1, CHEK2, RAD51
BRCA2	ESR1	No	15	SP1, MGMT, SMAD2, CDK2, FLNA, BARD1, HNRNPC, SMC3, STAT5A, SMAD3, TP53, SERPINH1, BRCA1, H2AFX, RAD51
BRCA2	PHB	No	4	MGMT, BRE, CDK2, TP53
BRCA2	PALB2	Yes	9	HNRNPC, BACH1, PALB2, USP11, PDS5B, POLH, BRCA1, MORF4L1, RAD51
BRCA2	CASP8	No	1	TP53
BRCA2	RAD51	Yes	19	SP1, ATM, FANCD2, XRCC3, MORF4L1, DMC1, BARD1, BRE, TP53, HNRNPC, MCPH1, PDS5B, RPA1, PCNA, BRCC3, BRCA1, H2AFX, RAD51, PALB2
BRCA2	PIK3CA	No	3	ATR, SMAD3, SMAD2
BARD1	KRAS	No	4	HNRNPC, MAPK1, ELAVL1, DDX50
BARD1	TP53	Yes	60	UBE2N, CDK1, PIAS1, RELA, UBE2K, FKBP3, CHD3, BRE, MDC1, PIAS4, BRD7, ZHX1, EWSR1, AURKB, ASH2L, MSH6, KAT7, BACH1, MTA2, MSH2, SRSF6, NPM1, SRSF1, BRCC3, MRPS22, YBX1, BRCA1, KPNB1, ESR1, YWHAZ, MED17, ING5, BARD1, KAT5, FOXK2, UBR5, ELAVL1, UIMC1, DCAF7, SRPK1, TRAPPC11, PARP1, H2AFX, UBE3A, MOV10, CCAR1, GTF3C4, BRCA2, AURKA, CDK2, XRCC6, WDR5, MAPK1, THRAP3, NFKBIA, TP53, TOP1, RBM39, WDR33, RAD51
BARD1	ESR1	Yes	63	GOLGA2, SRRM1, PIAS1, MTA2, XRCC6, CCNT1, SRSF2, SRSF5, TP53, THRAP3, RAD50, EWSR1, SRPK2, POLR2H, PGAM5, H2AFX, U2SURP, LUC7L3, DDX50, ASH2L, MSH2, SRSF6, CRIPAK, NPM1, SRSF1, SKP2, BRCA1, HIST2H2AC, ESR1, TOP1, SMC1A, MED17, RBM39, SRSF7, MAPK1, BARD1, SRRM2, FOXK2, SRPK1, AKAP8, UIMC1, RELA, PARP1, BCL3, RPS20, UBE3A, POLR2B, HNRNPC, TOPBP1, LRIF1, KAT5, CDK2, WDR5, U2AF2, TCERG1, YBX1, CIRBP, POLR2A, HIST1H2BG, RAD51, BCLAF1, POLR2E, XRCC5
BARD1	PHB	No	10	BRE, CDK2, OLA1, GTF3C1, TP53, YWHAZ, ESR1, NPM1, PARP1, SKP2
BARD1	PALB2	No	9	HNRNPC, BRCA2, BACH1, RBBP8, MOV10, HIST1H2BG, HIST1H3A, BRCA1, RAD51
BARD1	CASP8	No	6	TRAF1, CHD3, MAPK1, YBX1, TP53, PARP1
BARD1	RAD51	Yes	14	MSH6, HNRNPC, BRE, BRCA2, H2AFX, CHD3, BARD1, RAD51, TP53, MDC1, ESR1, BRCA1, MSH2, BRCC3
BARD1	PIK3CA	No	3	WDR5, RPS20, ESR1
KRAS	TP53	No	9	PHB, CCT7, BCL2, PML, MAPK1, ELAVL1, BTRC, EEF1A1, LIMA1
KRAS	ESR1	No	11	PHB, HNRNPC, CALM1, DDX50, MAPK1, PIK3CA, PIK3R2, TRAF6, BCAS3, SHOC2, SERPINB5
KRAS	PHB	Yes	3	BCAS3, CCL5, RAF1
KRAS	PALB2	No	7	HNRNPC, BCAS3, CCL5, IL24, SERPINB5, DIRAS3, THRSP
KRAS	CASP8	No	7	RALGDS, BCL2, QDPR, MAPK1, IL24, SERPINB5, TRAF6
KRAS	RAD51	No	5	HNRNPC, PML, IL24, ZDHHC17, DNAJA3
KRAS	PIK3CA	Yes	4	THRSP, TNFSF13, IL24, PIK3R2
TP53	ESR1	Yes	211	DDX5, PIAS1, TDG, RPL18A, SUPT6H, TRRAP, RPL28, RPL6, TRIM24, HDAC9, TOP2B, SNRPN, VCP, RPL5, TTK, NCOA3, SKI, CDK8, RBBP5, RPL12, DNMT3L, TOP1, SETD7, HECTD1, G3BP1, BARD1, MYO1C, RPL4, RPS4X, NCOA1, TP53, RELA, RPL11, PRDM2, UBE3A, HIF1A, EP400, PPP1CC, CORO1C, SKP1, FLNA, ANXA2, GNL3, ZBTB16, SFN, RPS2, WDR5, RPL7, RPS26, NFYA, HNRNPA1, IGF1R, EHMT2, RPS8, RRP1B, SAFB, THRAP3, OTUB1, SLC25A5, EWSR1, ARID1A, ASH2L, STUB1, SP1, CLTC, PRMT1, HSP90B1, GTF2H1, GSN, DDX3X, RPL8, RPS16, KAT6A, HSPB1, RPL3, DBN1, HDAC5, YTHDF1, RPS14, HEXIM1, PSMC5, KDM1A, PPARGC1A, ESR1, PIAS2, GAPDH, SIN3A, EIF2S2, RPLP0, HSP90AA1, ACTB, RBBP6, SRPK1, SMURF1, H2AFX, RPL24, RPL7A, MYO6, RBX1, RPS24, HDAC2, RPL23A, TUBB, GADD45A, MED21, RAD51, SERPINH1, RBBP4, MSH2, RPL18, HNRNPK, SIN3B, PABPC1, SRSF6, PARP1, TADA3, RPS6, RPL19, KAT5, RANBP9, CHUK, PHB, RPS18, TFRC, KLF5, HNRNPF, GRWD1, RBBP7, HNRNPA2B1, TUBA1A, SMAD3, MYBBP1A, BRCA1, SIRT1, MED17, SERBP1, RPL14, HDAC1, FOXK2, CCT2, CAPZB, TXNRD1, SET, PTEN, PPP2R1A, TAF1B, EP300, SMARCA4, SMARCD1, NR0B2, CDK2, G3BP2, MEN1, XRCC6, MYH9, PATZ1, RBM39, MNAT1, GNB2, RPS13, SMYD2, MDM2, TBP, MAPK1, S100A8, NCOR1, SAFB2, RPS3, RPS9, CCNH, CDK7, EEF2, MUC1, TAF1A, UIMC1, HNRNPM, NPM1, NCOA2, SRSF1, COPS5, MVP, HSPA1L, TUBA1C, RPL13, NCL, CDKN1A, GTPBP4, PRKDC, RPL21, RPL10A, ALYREF, RPS3A, TOP2A, SMAD2, MTA2, SRC, RPL37A, UBE4B, MYC, HSPA8, CREBBP, MTA1, HSPA4, MED1, YBX1, PPP1CA, MRPS9, SP3, UBE2I, ING1, TUBG1
TP53	PHB	Yes	33	BRE, HSP90AB1, VCP, HUWE1, YWHAE, TP53, RPS4X, SLC25A5, TAT, NCOR1, CLTC, PRKCD, NPM1, SMG5, LMNA, HDAC5, ESR1, YWHAZ, OBSL1, DBN1, HDAC1, SIN3A, RNF2, ACTB, PARP1, CDK2, ANXA2, CCDC8, RB1, RPL7, SMARCA4, UBC, CUL7
TP53	PALB2	No	8	CAPN1, BRCA2, BACH1, SNAI1, USP11, MOV10, BRCA1, RAD51
TP53	CASP8	Yes	28	TNFAIP3, TOPORS, BAX, TP53, VIM, CFLAR, HECTD3, CHUK, MAPK8, MAP1LC3B, PARK7, BLM, RNF34, BIRC6, CHD3, SQSTM1, CRYAB, SNRPD3, IKBKB, PTEN, PARP1, CASP8, BCL2, MAPK1, TSC22D3, YBX1, RB1, UBC
TP53	RAD51	Yes	33	ATM, USP10, PCNA, CHD3, BRE, MDC1, VIM, H2AFX, TUBG1, SP1, SUMO1, MSH2, BLM, RPA1, HNRNPA2B1, CSNK2B, BRCA1, BARD1, HSP90AA1, TP53, ABL1, MSH6, UBE2I, BRCC3, BRCA2, WRN, CHEK1, UHRF2, ESR1, CDC42, ATRX, PML, RAD51
TP53	PIK3CA	No	16	UFD1L, DDX5, ESR1, CRK, GSN, HRAS, PCBP1, WDR5, SMAD2, ATR, SMAD3, IRS4, DNAJB6, APPL1, HDAC1, SQSTM1
ESR1	PHB	Yes	37	ATP5B, VCP, TP53, SUZ12, MYOD1, RPS4X, MTCH2, SLC25A5, SKP2, MED20, CLTC, PHB2, NPM1, SYNCRIP, NCOR1, DBN1, HDAC5, HDAC1, BCAS3, ESR1, ACTN1, MED23, SIN3A, MGMT, ACTB, XPO1, PARP1, PLEC, E2F1, STAU1, SMARCA2, CDK2, FUS, ANXA2, RPL7, SMARCA4, CUL3
ESR1	PALB2	No	7	HNRNPC, BCAS3, SERPINB5, HIST1H2BG, CUL3, BRCA1, RAD51
ESR1	CASP8	No	24	ARHGDIA, TP53, CHUK, NR1H4, KLK9, KLK5, KHDRBS1, HDAC7, BAP1, HBP1, SERPINB5, GLCE, TRAF6, PTEN, PARP1, PSMC3IP, WHSC1L1, MAPK1, YBX1, CEBPB, EPSTI1, ATAD2, ANGPTL4, CUL3
ESR1	RAD51	Yes	18	SP1, UBE2I, FBXO18, PFN1, H2AFX, MSH2, BARD1, RAD51, TP53, HNRNPA2B1, HNRNPC, ELMSAN1, TUBG1, ESR1, NELFB, HSP90AA1, BRCA1, WHSC1L1
ESR1	PIK3CA	Yes	15	DDX5, SMAD2, AKT1, HDAC1, GSN, UBTF, PIK3R2, PSMC3IP, PIK3R1, SMAD3, IRS1, ESR1, IRS2, RPS20, WDR5
PHB	PALB2	No	3	BCAS3, CCL5, CUL3
PHB	CASP8	No	8	TP53, UBC, RB1, CUL3, ST14, PARP1, BCAP31, CASC3
PHB	RAD51	No	5	RAB5C, BRE, ESR1, ST14, TP53
PHB	PIK3CA	No	4	NTRK1, HDAC1, KRAS, ESR1
PALB2	CASP8	No	9	IL13RA2, IL24, ERRFI1, SERPINB5, CUL3, GREB1, LYPD3, PRDM14, USP2
PALB2	RAD51	Yes	12	IL24, BRCA2, MORF4L1, PALB2, HNRNPC, FAM84B, PDS5B, CST6, NAT2, BRCA1, RAD51AP1, RAD51
PALB2	PIK3CA	No	3	IL13RA2, IL24, THRSP
CASP8	RAD51	No	10	IL24, UMPS, CHD3, TP53, CASP3, BLM, VIM, CDH13, WHSC1L1, ST14
CASP8	PIK3CA	No	8	IL13RA2, TNFRSF1A, FASLG, BEX1, UMPS, PSMC3IP, IL24, SQSTM1
RAD51	PIK3CA	No	4	UMPS, IL24, BUB1, ESR1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
ATM	TP53	Yes	0
NQO2	KRAS	Yes	1	KRAS
BRCA1	TP53	No	2	CREBBP, EP300
BRCA1	RAD51	Yes	0
KRAS	TP53	No	1	EXOSC4
KRAS	CASP8	No	1	NOL3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
TSG101	HMMR	No	-	2	AR, TP53
TSG101	NQO2	No	-	1	UBC
TSG101	AKT1	No	-	12	CDKN1A, KRAS, MDM2, AR, RPS27A, TP53, SOS1, USP8, UBC, GRB2, UBB, NEDD4
TSG101	BRIP1	No	-	1	UBC
TSG101	RB1CC1	No	-	2	UBC, TP53
TSG101	PPM1D	No	-	3	UBC, TP53, MDM2
TSG101	FAM175A	No	-	1	UBC
TSG101	CDH1	No	-	7	AR, MDM2, HGS, TP53, EGF, EGFR, UBC
TSG101	CHEK2	No	-	4	UBC, CDKN1A, MDM2, TP53
TSG101	BRCA1	No	-	5	TP53, UBC, CDKN1A, AR, PABPC1
TSG101	BRCA2	No	-	2	AR, TP53
TSG101	BARD1	No	-	2	UBC, TP53
TSG101	KRAS	Yes	binding	6	SOS1, EGF, TP53, EGFR, UBC, GRB2
TSG101	TP53	Yes	activation, binding	12	MAP9, RPS27A, MDM2, NR3C1, AR, UBA52, CDKN1A, KRAS, EGFR, UBC, UBB, CEP55
TSG101	SLC22A18	No	-	1	UBC
TSG101	ESR1	No	-	9	CDKN1A, MDM2, NR3C1, AR, TP53, SOS1, EGFR, UBC, GRB2
TSG101	PHB	No	-	2	UBC, TP53
TSG101	RAD51	No	-	1	TP53
TSG101	PIK3CA	No	-	8	AR, KRAS, NR3C1, TP53, SOS1, EGFR, EGF, GRB2
HMMR	AKT1	No	-	6	AR, SLC9A1, HRAS, AURKA, TP53, CD44
HMMR	RB1CC1	No	-	1	TP53
HMMR	PPM1D	No	-	1	TP53
HMMR	CDH1	No	-	4	CD44, MTA1, AR, TP53
HMMR	CHEK2	No	-	1	TP53
HMMR	BRCA1	No	-	4	AR, AURKA, TP53, BACH1
HMMR	BRCA2	No	-	2	AR, TP53
HMMR	BARD1	No	-	3	AURKA, TP53, BACH1
HMMR	KRAS	No	-	2	HRAS, TP53
HMMR	TP53	Yes	binding, activation, expression	6	AR, HRAS, AURKA, MTA1, CSNK1A1, CD44
HMMR	ESR1	No	-	3	AR, MTA1, TP53
HMMR	PHB	No	-	1	TP53
HMMR	RAD51	No	-	1	TP53
HMMR	PIK3CA	No	-	3	HRAS, AR, TP53
NQO2	AKT1	No	-	1	UBC
NQO2	BRIP1	No	-	1	UBC
NQO2	RB1CC1	No	-	1	UBC
NQO2	PPM1D	No	-	1	UBC
NQO2	FAM175A	No	-	1	UBC
NQO2	CDH1	No	-	1	UBC
NQO2	CHEK2	No	-	1	UBC
NQO2	BRCA1	No	-	1	UBC
NQO2	BARD1	No	-	1	UBC
NQO2	KRAS	No	-	1	UBC
NQO2	TP53	No	-	1	UBC
NQO2	SLC22A18	No	-	1	UBC
NQO2	ESR1	No	-	1	UBC
NQO2	PHB	No	-	1	UBC
AKT1	BRIP1	No	-	4	UBC, BRCA1, TOPBP1, FOXM1
AKT1	RB1CC1	No	-	8	RPS6KB1, MLST8, SMAD7, RPTOR, MTOR, RB1, TP53, UBC
AKT1	PPM1D	No	-	10	BCL2L1, MDM2, RUNX2, CHEK1, TP53, JUN, UBC, MAPK14, PAK1, MDM4
AKT1	FAM175A	No	-	2	UBC, BRCA1
AKT1	CDH1	Yes	activation, binding	80	ZYX, CDH2, FOXM1, SNAI2, POSTN, ACTA1, TP53, SNAI1, RAC1, SMAD4, CAV1, FOXA2, GLI2, SERPINE1, CTGF, FOXO3, EZR, FOS, FGF2, SKP2, PTGS2, IQGAP1, CD44, PDCD4, ITGA6, ITGB4, NFKB1, RHOA, SMAD7, PIK3R1, PIK3CA, RAP1A, HDAC9, SMAD3, CTNNB1, TGFB1, ERBB3, LEP, CDC42, WT1, NOTCH1, STAT5A, RAP1B, GLI1, MDM2, F2R, AR, SLC3A2, IQGAP2, GAB2, IGF1, RPS6KB1, JUN, VAV1, PTEN, SRC, EP300, EFNA1, DLC1, STAT3, SMAD2, FGF13, RPTOR, BCL2, ILK, RICTOR, PRKCZ, MMP9, IGF2, RB1, TJP1, STAT5B, RAC3, EZH2, UBC, IRS2, MYC, CCND1, NOX1, FOXA1
AKT1	CHEK2	No	-	15	KAT2B, CDKN1A, MDM2, FOXM1, CHEK1, YWHAH, PPP2CA, TP53, MDM4, RB1, YWHAZ, SFN, UBC, BRCA1, CDC25C
AKT1	BRCA1	Yes	binding	38	AR, TERF1, TOPBP1, TP53, NPM1, BMI1, PCGF2, SKP2, CCND1, RB1, CREB1, STAT5A, SMAD3, CCNA2, CTNNB1, E2F1, SIRT1, CDKN1A, ESR1, HSP90AA1, JUN, ATF2, RELA, SRC, EP300, FANCA, HSPA8, UBE2D1, CREBBP, AURKA, PPP1CA, GADD45A, PIK3R1, HIF1A, CCNB1, UBC, MYC, CDKN1B
AKT1	BRCA2	No	-	9	AR, C11ORF30, CHEK1, FANCA, TP53, STAT5A, SMAD3, BRCA1, SNAI2
AKT1	BARD1	No	-	10	TOPBP1, UBE2D1, AURKA, FANCA, TP53, ESR1, UBC, BMI1, PCGF2, BRCA1
AKT1	KRAS	Yes	activation, binding	40	BCL2L1, PTPN11, TP53, SPHK1, NPM1, PIK3CG, LGALS3, VEGFA, YWHAB, HSP90AA1, GRB2, ANGPT1, BCL2, CCND1, PIK3CA, ERBB3, RAF1, SOS1, SHC1, AKT2, SLC3A2, HRAS, RALGDS, BTRC, RPS6KB1, JUN, PPP2CA, CTGF, SRC, BCL2L11, MAPK14, NOTCH1, PIK3CB, MTOR, IRS2, UBC, IRS1, PIK3CD, BRAF, MDM4
AKT1	TP53	Yes	binding, activation, expression	139	WWOX, RELA, CAV1, NPM1, HDAC9, VEGFA, FOXO3, HTT, CXCL12, STAT5A, COPS5, MAPK14, BAX, BDNF, JUN, NR4A1, FOXM1, MMP9, MTOR, MCL1, YWHAG, ESR1, KAT2B, BCL2L1, RUNX2, YWHAE, IGFBP3, SERPINE1, FGF2, STUB1, PTGS2, PIAS2, EGR1, PARK7, THBS1, RB1, CAT, CCNA2, SFN, TSC2, GAPDH, AR, CDH1, ANKRD2, HSP90AA1, LGALS3, AURKA, TERT, MMP2, GADD45A, S100B, MDM4, CCNB1, UBC, HIF1A, SP7, MMP1, SLC2A4, SMAD4, BTRC, CREB1, CFLAR, HSPA5, FOS, NCOR1, PHB, NOS3, PHF20, GDF15, NFKB1, CCND1, CD44, KRAS, BMI1, AXIN1, SMAD3, RAF1, BRCA1, SIRT1, WT1, BIRC5, FOXO1, HSPB3, HRAS, NOTCH1, SMAD2, NFE2L2, PTEN, PPP2R1A, ICAM1, EP300, SHH, UBE2D1, CHEK1, EZH2, RUNX3, APAF1, HMOX1, CDC25C, PTPN11, MDM2, HSPB2-C11ORF52, SNAI1, TOPBP1, SNAI2, WEE1, BAIAP2L1, UBB, RPS27A, BCL2, SMAD7, PPP2R4, PIK3CA, CLU, DNMT1, SKP2, TGFB1, PPP2R5C, YWHAZ, CDKN1A, SERPINH1, TRAF6, STAT5B, CTGF, PARP1, GSK3B, MYC, STAT3, HSPA8, POLI, CREBBP, HSPA4, IKBKB, YBX1, IL6, ATIC, LEP, MAP3K8, PDCD4
AKT1	SLC22A18	No	-	1	UBC
AKT1	ESR1	Yes	activation, binding	84	MYC, AR, PELP1, PTEN, MDM2, RRAS2, RAC3, EZH2, CDKN1A, TP53, NOS3, SRC, CAV1, MAPK14, ATF2, SOS1, GNB1, CTGF, NRIP1, HDAC9, FOS, VEGFA, STUB1, PHB, GNAI3, PTGES3, FOXO3, RXRG, FOXM1, STRN, GNAO1, GNAI1, CXCL12, MAPT, HDAC3, PIK3CA, NCOR2, STAT5A, SMAD3, NCOR1, SMAD2, COPS5, SHC1, FOXO4, SIRT1, TSC2, AKT2, FOXO1, SOD1, GAPDH, TERT, STAT3, RARA, MYOD1, HSP90AA1, JUN, NR4A1, SMAD4, RELA, RHOA, PARP1, PAK1, EP300, BRCA1, E2F1, FKBP5, FKBP4, HSPA8, CREBBP, HSPA4, SNAI2, FASN, HEXIM1, INS, IL6, PIK3R1, GNAZ, IGF1, UBC, IRS1, GRB2, LEP, CCND1, FOXA1
AKT1	PHB	Yes	binding, ptmod	9	RAF1, TP53, RB1, NCOR1, ESR1, UBC, E2F1, VDAC1, YWHAZ
AKT1	PALB2	No	-	1	BRCA1
AKT1	RAD51	No	-	8	EGR1, FOXM1, CHEK1, IRS1, POLI, TP53, BRCA1, BCR
AKT1	PIK3CA	Yes	activation, binding	108	ITGB3, PTEN, PLCG1, TP53, CDC42, SOS1, RAP1A, PDGFB, ACTN4, PDGFRB, ACTA1, CTNNB1, GNGT1, BECN1, BDNF, PIK3CB, RELA, CBLB, RELN, IL2, RRAS2, MTOR, INS, JAK1, PIK3R5, GNB1, ESR1, VAV2, FLT3, BCL2L1, AKT2, ITGA2B, RPTOR, PGF, ANGPT2, ITGA6, RHOA, PREX1, PIK3R1, BCR, RPS6KB2, APPL1, IGF1, PTPN1, CDH1, PIK3R3, PDPK1, ITGB4, GRB2, GAB1, PIK3CD, ZYX, PELP1, VLDLR, AR, CSK, TPTE2, RAP1B, DAB1, INSR, GSK3B, CCND1, CREB1, SMAD3, RAF1, ERBB3, TPTE, LCK, HRAS, NOTCH1, GAB2, DOK1, CDH2, VEGFA, RAC1, RICTOR, PRKCZ, GNAI3, CASP9, IL2RB, EFNA1, RAC3, PTPN11, MAP3K5, PIK3CG, GNAI1, DAB2IP, ANGPT1, RRAS, SHC1, YWHAZ, CSF2, TSC1, S1PR1, SLC9A3R1, SMAD2, SRC, NFKB1, MYC, STAT3, KRAS, IL3, ARF6, RPS6KB1, IRS1, VAV1, IRS2, LAT
BRIP1	XRCC3	No	-	3	BLM, BRCA2, MLH1
BRIP1	RB1CC1	No	-	1	UBC
BRIP1	PPM1D	No	-	1	UBC
BRIP1	RAD54L	No	-	1	BLM
BRIP1	FAM175A	No	-	2	UBC, BRCA1
BRIP1	CDH1	No	-	2	UBC, FOXM1
BRIP1	CHEK2	No	-	5	UBC, BRCA1, BRCA2, FOXM1, PLK1
BRIP1	BRCA1	Yes	binding	8	TOPBP1, BRCA2, PALB2, RPA1, BLM, PLK1, UBC, MLH1
BRIP1	BRCA2	Yes	binding	7	PALB2, RPA1, BLM, PLK1, BRCA1, TOP3A, MLH1
BRIP1	BARD1	No	-	3	UBC, BRCA1, TOPBP1
BRIP1	KRAS	No	-	1	UBC
BRIP1	TP53	No	-	11	TOPBP1, BRCA2, FOXM1, ERCC2, MLH1, PMS2, RPA1, BLM, PLK1, UBC, BRCA1
BRIP1	SLC22A18	No	-	1	UBC
BRIP1	ESR1	No	-	3	UBC, BRCA1, FOXM1
BRIP1	PHB	No	-	1	UBC
BRIP1	PALB2	Yes	binding	2	BRCA1, BRCA2
BRIP1	RAD51	No	-	10	PMS2, BRCA2, FOXM1, PALB2, RPA1, BLM, PLK1, BRCA1, TOP3A, MLH1
XRCC3	PPM1D	No	-	0
XRCC3	RAD54L	Yes	binding	8	WRN, DMC1, BLM, RAD51, RAD51C, RECQL, RAD51B, RAD51D
XRCC3	FAM175A	No	-	0
XRCC3	CHEK2	No	-	3	RAD52, BRCA2, WRN
XRCC3	BRCA1	No	-	11	ACACA, BRCA2, MLH1, BLM, FANCG, RAD51C, RAD51B, POLH, DMC1, RAD51, FANCD2
XRCC3	BRCA2	Yes	activation, binding	9	FANCD2, RAD51D, MLH1, BLM, FANCG, RAD51C, RAD51B, DMC1, RAD51
XRCC3	BARD1	No	-	3	FANCD2, RAD51, FANCG
XRCC3	TP53	No	-	6	BRCA2, WRN, MLH1, BLM, POLH, RAD51
XRCC3	PALB2	No	-	4	FANCD2, BRCA2, RAD51, RAD51C
XRCC3	RAD51	Yes	binding	16	FBXO18, BRCA2, BLM, WRN, MLH1, DMC1, ACACA, TTF2, RAD54B, ACACB, REV1, RAD52, RAD54L, POLH, RECQL, RAD51C
RB1CC1	PPM1D	No	-	2	UBC, TP53
RB1CC1	FAM175A	No	-	1	UBC
RB1CC1	CDH1	No	-	6	RPS6KB1, SMAD7, RPTOR, TP53, RB1, UBC
RB1CC1	CHEK2	No	-	3	UBC, RB1, TP53
RB1CC1	BRCA1	No	-	4	UBC, SMARCB1, RB1, TP53
RB1CC1	BRCA2	No	-	1	TP53
RB1CC1	BARD1	No	-	2	UBC, TP53
RB1CC1	KRAS	No	-	5	MTOR, UBC, RPS6KB1, PTK2, TP53
RB1CC1	TP53	Yes	activation, binding	8	PTK2B, SMAD7, PIAS4, MTOR, RB1, PTK2, UBC, SMARCB1
RB1CC1	SLC22A18	Yes	binding	1	UBC
RB1CC1	ESR1	No	-	2	UBC, TP53
RB1CC1	PHB	No	-	3	UBC, RB1, TP53
RB1CC1	RAD51	No	-	1	TP53
RB1CC1	PIK3CA	No	-	5	MTOR, RPTOR, RPS6KB1, TP53, PTK2
PPM1D	FAM175A	No	-	2	UBC, H2AFX
PPM1D	CDH1	No	-	5	UBC, JUN, MAPK3, TP53, MDM2
PPM1D	CHEK2	Yes	binding, ptmod	6	MDM2, CHEK1, TP53, UBC, H2AFX, MDM4
PPM1D	BRCA1	No	-	5	UBC, CHEK2, H2AFX, JUN, TP53
PPM1D	BRCA2	No	-	4	CHEK2, CHEK1, H2AFX, TP53
PPM1D	BARD1	No	-	3	UBC, H2AFX, TP53
PPM1D	KRAS	No	-	10	BCL2L1, MAPK11, MAPK3, TP53, JUN, MAPK13, UBC, MAPK14, MAPK12, MDM4
PPM1D	TP53	Yes	activation	15	BCL2L1, MAPK11, RUNX2, CHEK1, MAPK3, MAPK13, JUN, MAPK12, MDM2, UBC, CHEK2, H2AFX, HIPK2, MAPK14, MDM4
PPM1D	SLC22A18	No	-	1	UBC
PPM1D	ESR1	No	-	8	MDM2, MAPK11, MAPK3, TP53, JUN, UBC, MAPK14, PAK1
PPM1D	PHB	No	-	2	UBC, TP53
PPM1D	RAD51	No	-	3	H2AFX, CHEK1, TP53
PPM1D	PIK3CA	No	-	2	BCL2L1, TP53
RAD54L	CHEK2	No	-	2	MUS81, WRN
RAD54L	BRCA1	No	-	5	RAD51B, BLM, RAD51, DMC1, RAD51C
RAD54L	BRCA2	No	-	7	RAD51D, DMC1, BLM, RAD51, XRCC3, RAD51B, RAD51C
RAD54L	BARD1	No	-	1	RAD51
RAD54L	TP53	No	-	3	BLM, RAD51, WRN
RAD54L	PALB2	No	-	2	RAD51, RAD51C
RAD54L	RAD51	Yes	binding	6	WRN, DMC1, BLM, XRCC3, RECQL, RAD51C
FAM175A	CDH1	No	-	1	UBC
FAM175A	CHEK2	No	-	6	TP53BP1, RAD50, UBC, BRCA1, H2AFX, RNF8
FAM175A	BRCA1	Yes	binding	10	BRE, BABAM1, BARD1, TP53BP1, UIMC1, RAD50, UBC, H2AFX, SUMO2, RNF8
FAM175A	BRCA2	No	-	2	BRCA1, H2AFX
FAM175A	BARD1	Yes	binding	7	BRE, BABAM1, UIMC1, RAD50, UBC, BRCA1, H2AFX
FAM175A	KRAS	No	-	1	UBC
FAM175A	TP53	No	-	7	BARD1, TP53BP1, UIMC1, UBC, BRCA1, SUMO2, H2AFX
FAM175A	SLC22A18	No	-	1	UBC
FAM175A	ESR1	No	-	3	UBC, BRCA1, BARD1
FAM175A	PHB	No	-	2	UBC, BRE
FAM175A	PALB2	No	-	1	BRCA1
FAM175A	RAD51	No	-	6	BRE, BARD1, TP53BP1, BRCA1, SUMO2, H2AFX
CDH1	CHEK2	No	-	6	VHL, FOXM1, MDM2, TP53, RB1, UBC
CDH1	BRCA1	No	-	27	AR, AKT1, TP53, ANAPC11, CTBP1, SKP2, SUMO1, CCND1, RB1, CDC27, STAT5A, SMAD3, CTNNB1, CDC23, HDAC1, JUN, ABL1, SRC, EP300, FHL2, ANAPC7, HDAC2, CBX7, PIK3R1, SMARCA4, UBC, MYC
CDH1	BRCA2	No	-	5	TP53, SNAI2, SMAD3, STAT5A, AR
CDH1	BARD1	No	-	7	ANAPC7, TP53, CBX7, CDC27, ANAPC11, UBC, CDC23
CDH1	KRAS	No	-	31	AKT1, BMP4, MAPK3, RET, TP53, EGFR, CTGF, IGF2BP1, BCL2, CCND1, PIK3CA, EPHA2, ERBB2, ERBB3, KIT, IRS2, SLC3A2, PRMT5, UBC, RPS6KB1, IL8, ABL1, SRC, FYN, YES1, NOTCH1, MAPK1, JUN, CDX1, CDX2, EGF
CDH1	TP53	Yes	activation, binding	83	PKD1, VHL, AR, ABL1, FOXM1, BCL2, MET, MAPK3, ZEB2, SNAI1, HOXA10, TWIST1, SMAD4, CAV1, RGCC, MTA3, NRP2, SERPINE1, CTGF, HDAC9, FOS, FGF2, SKP2, PTGS2, CD44, ID2, MDM2, SUMO1, CTCF, NFKB1, KLF5, SMAD7, RB1, PIK3CA, EPHA2, ERBB2, SMAD3, FHL2, CD82, TGFB1, TGM2, NUMB, WT1, PPARGC1A, STAT5A, CA9, HGF, MAPK1, CCNG1, HDAC1, PRMT5, STAT3, SMAD2, JUN, S100A4, PSEN1, AKT1, SIK1, HMGA2, EP300, FOXO3, SNAI2, NOTCH1, EGFR, MYO6, SIRT3, STAT5B, CCND1, IGF1R, MTA1, HDAC2, EZH2, CTBP1, MMP9, PTEN, SMARCA4, UBC, MYC, LEP, PPARG, KLF4, PDLIM7, PDCD4
CDH1	SLC22A18	No	-	1	UBC
CDH1	ESR1	No	-	53	AR, ABL1, FOXM1, HDAC2, TP53, MAPK1, TWIST1, CAV1, EGFR, CTGF, HDAC9, FOS, MDM2, SUMO1, CTBP1, RHOA, ERBB2, PIK3CA, MTA1, SMAD3, CD82, MACROD1, FOXO3, GNA13, PPARGC1A, STAT5A, IGF1, ESR2, HDAC1, SMAD2, JUN, SMAD4, AKT1, SRC, MTA3, EP300, LEP, SNAI2, STAT3, WNT7A, IGF1R, MAPK3, EZH2, PIK3R1, PTEN, FOXA1, SMARCA4, UBC, MYC, CCND1, PPARG, KLF5, RAC3
CDH1	PHB	No	-	6	AKT1, HDAC1, TP53, RB1, SMARCA4, UBC
CDH1	RAD51	No	-	5	SUMO1, TP53, FOXM1, SMARCA4, ABL1
CDH1	PIK3CA	Yes	activation, binding	58	RAC1, CDH2, MET, CD2AP, RET, ZYX, VCL, ACTN1, CTNND1, CDC42, EGFR, RAP1B, DLG1, HGF, ITGA6, GFRA1, ITGB4, RHOA, ACTA1, CTNNA1, RAP1A, EPHA2, ERBB2, SMAD3, TLN1, CTNNB1, ERBB3, KIT, PRKCA, PRKCI, AR, NOTCH1, GAB2, TP53, RPS6KB1, SMAD2, AKT1, SRC, FYN, NFKB1, EFNA1, YES1, STAT3, GDNF, IL4, RICTOR, VAV1, PRKCZ, RPTOR, PIK3R1, PTEN, IGF1, EGF, IRS2, MYC, CCND1, IGF1R, RAC3
CHEK2	BRCA1	Yes	activation, binding	15	TP53BP1, ATR, TREX1, MSH2, TOP2A, CDKN1A, PLK1, RB1, RAD50, TP53, UBC, BRCA2, H2AFX, TP73, RNF8
CHEK2	BRCA2	Yes	binding, ptmod	7	ATR, TREX1, CHEK1, PLK1, TP53, H2AFX, BRCA1
CHEK2	BARD1	No	-	7	ATR, MSH2, TP53, RAD50, UBC, H2AFX, BRCA1
CHEK2	KRAS	No	-	4	UBC, TP53, PPP2CA, MDM4
CHEK2	TP53	Yes	activation, binding	33	KAT2B, PLK3, TREX1, MDM2, CHEK1, CDC25A, TP53BP1, ATR, FOXM1, MSH2, PPM1D, RCHY1, BRCA1, YWHAZ, VHL, CDKN1A, ELAVL1, TOP2A, H2AFX, BRCA2, TP63, WRN, CABIN1, ASF1A, PLK1, KPNA2, RB1, MDM4, SFN, UBC, TP73, PML, CDC25C
CHEK2	SLC22A18	No	-	1	UBC
CHEK2	ESR1	No	-	7	CDKN1A, MDM2, FOXM1, MSH2, TP53, UBC, BRCA1
CHEK2	PHB	No	-	4	UBC, RB1, TP53, YWHAZ
CHEK2	PALB2	No	-	2	BRCA1, BRCA2
CHEK2	RAD51	No	-	11	TP53BP1, BRCA2, FOXM1, WRN, MSH2, CHEK1, PLK1, TP53, RAD52, H2AFX, BRCA1
CHEK2	PIK3CA	No	-	2	TP53, YWHAZ
BRCA1	BRCA2	Yes	binding	32	AR, TREX1, H2AFX, FANCD2, SHFM1, TEX15, HIST3H3, RPA3, RAD51B, ATR, MLH1, RAD51, RPA1, STAT5A, SMAD3, RPA2, PALB2, FANCI, DMC1, TP53, PSMC3IP, BRIP1, FANCA, CDK2, CDK4, BUB1B, PLK1, BLM, FANCG, MND1, CHEK2, RAD51C
BRCA1	BARD1	Yes	binding	65	ANAPC4, CDC26, ANAPC11, UBE2L3, H2AFX, AURKA, FANCD2, BRE, ANAPC15, FAM175A, FANCE, PHC2, RAD50, ANAPC13, CBX2, PCNA, BMI1, BABAM1, UBE2D2, CCNE1, CUL7, BACH1, PCGF2, MSH2, RAD51, ANAPC2, CDC27, PCGF6, CSTF1, FANCF, CBX8, RBBP8, ANAPC5, ANAPC16, CDC23, TOPBP1, CBX4, UBE2C, CDK2, UBE2N, ATR, UBE2D3, ANAPC7, UIMC1, CDC16, FANCC, RBX1, MSH6, PHC1, ANAPC1, ANAPC10, FANCA, RNF2, UBE2S, UBE2D1, FANCL, BUB1B, CBX7, TP53, FANCG, ESR1, UBC, CSTF2, PHC3, XRCC5
BRCA1	KRAS	No	-	9	ABL1, CCND1, TP53, UBC, JUN, HSP90AA1, AKT1, NPM1, SRC
BRCA1	TP53	Yes	activation, binding	82	STAG2, AURKA, TREX1, CDK2, UBE2K, PCNA, NCOA3, TOPORS, RPA1, SMARCB1, MNAT1, CDK4, POLH, ERCC6, CDK1, BMI1, CTBP1, MSH6, SKP2, SP1, TERF2, AR, E2F4, SUMO1, TP73, EP300, CCND1, ABL1, STAT5A, CREB1, CDK8, SRSF1, TFDP1, CCNA2, SMAD3, SUMO3, SIRT1, UBE2I, CDKN1A, CCNB1, SMARCA4, ZNF148, TOPBP1, VDR, UBE2N, HDAC1, RB1, BARD1, ATR, RNF2, HSP90AA1, JUN, TOP2A, RAD51, AKT1, NPM1, RPA3, BRCA2, H2AFX, SUMO2, CHEK2, FHL2, TP53BP1, USP7, MSH2, HSPA8, XRCC5, UBE2D1, CCNA1, CREBBP, HDAC2, UIMC1, PLK1, GADD45A, BLM, HIF1A, ESR1, UBC, MYC, RELA, MLH1, CUL7
BRCA1	SLC22A18	No	-	1	UBC
BRCA1	ESR1	Yes	binding	44	AR, AKT1, TP53, ATF2, PGR, PCNA, SP1, SUMO1, CTBP1, MSH2, NCOA3, POLR2A, STAT5A, SMAD3, AHR, NCOA2, E2F1, SIRT1, UBE2I, CDKN1A, MED17, GTF2E1, VDR, HDAC1, BARD1, COBRA1, HSP90AA1, JUN, LMO4, ABL1, SRC, EP300, MNAT1, SMARCA2, HSPA8, CREBBP, HDAC2, PIK3R1, GTF2F1, SMARCA4, UBC, MYC, RELA, CCND1
BRCA1	PHB	No	-	11	SMARCA2, AKT1, HDAC1, BRE, RNF2, RB1, TP53, ESR1, UBC, E2F1, SMARCA4
BRCA1	PALB2	Yes	binding	8	FANCI, BRCA2, MORF4L1, RBBP8, RAD51C, BRIP1, FANCD2, RAD51
BRCA1	RAD51	Yes	activation, binding	34	BRE, HIST3H3, ABL1, H2AFX, PALB2, ACACA, TP53, TEX15, TP53BP1, RPA3, MSH6, SUMO1, MSH2, RPA1, RPA2, MND1, RAD18, DMC1, BARD1, SMARCA2, CDK4, PCNA, PSMC3IP, SUMO2, UBE2I, MSH3, BRCA2, CDK2, PLK1, BLM, SMARCA4, POLH, MLH1, RAD51C
BRCA1	PIK3CA	No	-	14	SP1, AR, CTNNB1, CCND1, RELA, CREB1, PIK3R1, SMAD3, TP53, ESR1, SRC, PGR, AKT1, MYC
BRCA2	BARD1	No	-	11	AURKB, FANCA, CDK2, FANCD2, BUB1B, ATR, TP53, RAD51, BRCA1, H2AFX, FANCG
BRCA2	KRAS	No	-	1	TP53
BRCA2	TP53	Yes	activation, binding	20	AURKB, AR, STAT5A, TREX1, CDK2, CDK4, BCCIP, CHEK1, ATR, RPA1, BLM, SMAD3, PLK1, RPA3, SNAI2, CHEK2, H2AFX, BRCA1, RAD51, MLH1
BRCA2	ESR1	No	-	6	AR, STAT5A, TP53, SNAI2, SMAD3, BRCA1
BRCA2	PHB	No	-	1	TP53
BRCA2	PALB2	Yes	binding	6	FANCI, FANCD2, RAD51, BRCA1, BRIP1, RAD51C
BRCA2	RAD51	Yes	activation, binding	24	HIST3H3, PALB2, TP53, TEX15, MSH4, XRCC3, RPA3, TOP3A, PSMC3IP, MLH1, RPA1, MCPH1, RPA2, BRCA1, DMC1, CDK4, H2AFX, CDK2, CHEK1, PLK1, BLM, MLH3, MND1, RAD51C
BRCA2	PIK3CA	No	-	3	AR, SMAD3, TP53
BARD1	KRAS	No	-	2	UBC, TP53
BARD1	TP53	Yes	activation, binding	22	AURKB, XRCC6, EWSR1, BMI1, MSH6, ATR, MSH2, BRCA1, TOPBP1, UBE2N, RNF2, UIMC1, PCNA, H2AFX, CDK2, UBE2D1, AURKA, XRCC5, CUL7, ESR1, UBC, RAD51
BARD1	SLC22A18	No	-	1	UBC
BARD1	ESR1	Yes	binding	5	UBC, BRCA1, MSH2, TP53, PCNA
BARD1	PHB	No	-	5	UBC, BRE, ESR1, TP53, RNF2
BARD1	PALB2	No	-	4	BRCA1, RBBP8, FANCD2, RAD51
BARD1	RAD51	Yes	binding	8	MSH6, BRE, CDK2, MSH2, TP53, PCNA, H2AFX, BRCA1
BARD1	PIK3CA	No	-	2	ESR1, TP53
KRAS	TP53	Yes	activation, binding	40	BCL2L1, ABL1, MAPK1, PTPN11, ETS2, BTRC, NPM1, EGFR, HBEGF, LGALS3, PRMT1, MAPK11, CTGF, CCND1, PTK2, MDM4, EPHA2, ERBB2, RAF1, MAPK14, MAPK7, NCL, HRAS, PRMT5, NOTCH1, MAPK13, JUN, HSP90AA1, AKT1, VEGFA, MAPK12, ETS1, MGMT, BCL2, MAPK3, MTOR, ERBB4, PIK3CA, UBC, TSG101
KRAS	SLC22A18	No	-	1	UBC
KRAS	ESR1	No	-	26	AKT1, MAPK1, TP53, SOS1, EGFR, CTGF, PRMT1, MAPK11, PPARD, PIK3CA, ERBB2, MAPK14, AKT2, HSP90AA1, JUN, NT5E, ABL1, SRC, VEGFA, SHC1, MGMT, MAPK3, IRS1, UBC, GRB2, CCND1
KRAS	PHB	No	-	4	UBC, RAF1, TP53, AKT1
KRAS	RAD51	No	-	3	IRS1, TP53, ABL1
KRAS	PIK3CA	Yes	activation, binding	37	BCL2L1, EGFR, RET, MAP2K2, TP53, SOS1, PIK3CG, TEK, VEGFA, ANGPT1, MAP2K1, PTK2, EPHA2, ERBB2, ERBB3, RAF1, SHC1, AKT2, KIT, HRAS, RPS6KB1, GRB2, AKT1, SRC, FYN, FRS2, YES1, NOTCH1, PTPN11, PIK3CB, MTOR, IRS2, EGF, IRS1, PIK3CD, CCND1, ERBB4
TP53	SLC22A18	No	-	2	UBC, RB1CC1
TP53	ESR1	Yes	activation, binding	109	POU4F2, ABL1, CAV1, TRIM24, HDAC9, PCNA, FOXO3, MAP3K1, NCOA3, ERBB2, RBBP5, MAPK14, BARD1, JUN, POU4F1, NR4A1, AKT1, PRDM2, EP400, NEDD8, MAPK3, HMGA1, SMARCA4, AR, EGFR, STK11, TWIST1, EZH2, MYB, ASH2L, STUB1, SP1, CARM1, KDM1A, PPARGC1A, TERT, TSC2, GAPDH, NR4A2, HSP90AA1, MAPK11, IGF1R, HDAC2, UBC, MSH2, MTA2, SMAD4, KAT5, FOS, NCOR1, PHB, NOS3, FOXM1, SUMO1, CCND1, KLF5, STAT5A, MTA1, SMAD3, FOXO1, BRCA1, SIRT1, HDAC1, SMAD2, MED1, PTEN, VEGFA, EP300, LEP, MGMT, NR0B2, WDR5, TADA3, MNAT1, HNF4A, MDM2, TBP, MAPK1, XPO1, SNAI2, CXCL12, CTBP1, MUC1, PIK3CA, CDK9, COPS5, CD82, COL18A1, CDKN1A, VDR, SIN3A, CTSD, CTGF, PARP1, PRMT1, MTA3, UBE2I, STAT3, HSPA8, NR3C1, DDX17, CREBBP, HSPA4, PAGR1, IL6, SP3, MYC, RELA, PPARG
TP53	PHB	Yes	activation, binding	12	RAF1, HDAC1, ANXA2, RNF2, RB1, NCOR1, ESR1, UBC, SMARCA4, AKT1, HIC1, YWHAZ
TP53	PALB2	No	-	3	BRCA1, BRCA2, RAD51
TP53	RAD51	Yes	activation, binding	29	PCNA, FOXM1, CDK4, PLK1, RPA3, H2AFX, RAD9A, EGR1, MSH2, RPA1, BRCA1, CDK2, BARD1, SUMO1, ABL1, MSH6, SUMO2, UBE2I, PMS2, BRCA2, POLI, WRN, CHEK1, TP53BP1, BLM, SMARCA4, POLH, UBE2A, MLH1
TP53	PIK3CA	Yes	activation, expression	42	BCL2L1, PTEN, MET, EPHB4, LYN, AGT, CREB1, EGFR, SP1, PRKCD, GSK3B, CCND1, PTK2, EPHA2, ERBB2, SMAD3, RAF1, NGFR, YWHAZ, HGF, AR, HRAS, EFNB1, NOTCH1, CDH1, SMAD2, AKT1, NTN1, VEGFA, NFKB1, STAT3, KRAS, NR3C1, PTPN11, BDNF, RELA, MTOR, SGK1, ESR1, MYC, IGF1R, ERBB4
SLC22A18	ESR1	No	-	1	UBC
SLC22A18	PHB	No	-	1	UBC
ESR1	PHB	Yes	binding	8	SMARCA2, SMARCA4, HDAC1, TP53, AKT1, UBC, E2F1, NCOR1
ESR1	PALB2	No	-	1	BRCA1
ESR1	RAD51	No	-	13	SMARCA2, FOXM1, SUMO1, MSH2, BARD1, TP53, CEBPB, ABL1, IRS1, PCNA, BRCA1, UBE2I, SMARCA4
ESR1	PIK3CA	Yes	activation, binding	44	AR, PELP1, PGR, GNG2, GNA11, GNA15, TP53, CCND3, SOS1, EGFR, GNAI1, SP1, INS, RHOA, THRB, ERBB2, SMAD3, SGK3, SHC1, GNB1, AKT2, THRA, RPS6KA3, GNA14, SMAD2, AKT1, SRC, VEGFA, GRB2, STAT3, NR3C1, IGF1R, RRAS2, IRS1, GNAI3, PIK3R1, PTEN, RAC3, IGF1, GNAQ, MYC, RELA, CCND1, BCAR1
PHB	RAD51	No	-	4	SMARCA2, TP53, SMARCA4, BRE
PHB	PIK3CA	No	-	5	TP53, RAF1, ESR1, AKT1, YWHAZ
PALB2	RAD51	Yes	binding	3	BRCA1, BRCA2, RAD51C
RAD51	PIK3CA	No	-	3	BCR, IRS1, TP53

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
ATM	BRIP1	No	-	1	BRCA1
ATM	FAM175A	No	-	1	BRCA1
ATM	NBN	Yes	MDC1-MRN-ATM-FANCD2 complex;ATM-NBS1 complex;BASC complex (BRCA1-associated genome surveillance complex)	13	ATM, FANCD2, RFC2, MSH2, MSH6, MDC1, BLM, MRE11A, RFC1, RFC4, RAD50, BRCA1, MLH1
ATM	BRCA1	Yes	BASC (Ab 81) complex (BRCA1-associated genome surveillance complex);BASC complex (BRCA1-associated genome surveillance complex)	11	ATM, NBN, MSH2, MRE11A, MSH6, RFC1, BLM, RAD50, RFC4, RFC2, MLH1
ATM	BRCA2	No	-	1	BRCA1
ATM	BARD1	No	-	6	NBN, MRE11A, RAD50, MSH6, BRCA1, MLH1
ATM	TP53	No	-	3	MSH6, BLM, MSH2
ATM	RAD51	No	-	4	MSH6, BRCA1, MSH2, BLM
BRIP1	FAM175A	No	-	1	BRCA1
BRIP1	NBN	No	-	1	BRCA1
BRIP1	BRCA1	Yes	BRCA1-BACH1 complex	0
BRIP1	BRCA2	No	-	1	BRCA1
BRIP1	BARD1	No	-	1	BRCA1
BRIP1	RAD51	No	-	1	BRCA1
XRCC3	RAD51	No	-	1	XRCC2
FAM175A	NBN	No	-	2	BRCA1, BARD1
FAM175A	BRCA1	Yes	BRCA1 A complex	2	UIMC1, BARD1
FAM175A	BRCA2	No	-	2	BRCA1, BARD1
FAM175A	BARD1	Yes	BRCA1 A complex	2	BRCA1, UIMC1
FAM175A	TP53	No	-	1	BARD1
FAM175A	RAD51	No	-	1	BRCA1
NBN	BRCA1	Yes	BRCA1-BARD1-BACH1-DNA damage complex II;BRCA1-RAD50-MRE11-NBS1 complex;BASC complex (BRCA1-associated genome surveillance complex)	15	ATM, TOPBP1, RFC2, BACH1, MLH1, BARD1, TRRAP, RFC1, MRE11A, BLM, RBBP8, RFC4, RAD50, MSH6, MSH2
NBN	BRCA2	No	-	2	BRCA1, BARD1
NBN	BARD1	Yes	BRCA1-BARD1-BACH1-DNA damage complex II	9	TOPBP1, BACH1, MRE11A, XRCC6, RBBP8, RAD50, MSH6, BRCA1, MLH1
NBN	TP53	No	-	5	MSH6, BARD1, BLM, XRCC6, MSH2
NBN	ESR1	No	-	1	TRRAP
NBN	RAD51	No	-	4	MSH6, BRCA1, MSH2, BLM
CDH1	BRCA1	No	-	1	SMAD3
CDH1	ESR1	No	-	2	SRC, BCAR1
BRCA1	BRCA2	Yes	BRCC complex;BRCA1-BARD1-BRCA2-DNA damage complex III	6	BRE, HDAC2, HDAC1, BARD1, BRCC3, RAD51
BRCA1	BARD1	Yes	BARD1-BRCA1-CSTF64 complex;BRCA1-BARD1-UbcH7c complex;HUIC complex;BRCA1-BARD1-POLR2A complex;BARD1-BRCA1-CSTF complex;BRCA1-BARD1-BRCA2-DNA damage complex III;BRCA1 B complex;BRCA1-BARD1-BACH1-DNA damage complex II;BRCA1 C complex;BRCA1-BARD1-UbcH5c complex;BRCA1-BARD1-BACH1-DNA damage complex I;BRCA1 A complex	17	NBN, TOPBP1, BRCA2, BACH1, MRE11A, UIMC1, UBE2L3, CSTF3, FAM175A, POLR2A, RBBP8, UBE2D3, RAD50, CSTF2, MSH6, MLH1, CSTF1
BRCA1	TP53	No	-	5	MSH6, BLM, BARD1, MSH2, RAD51
BRCA1	ESR1	No	-	3	TRRAP, HDAC2, KAT2A
BRCA1	RAD51	Yes	BRCC complex;BRCA1-RAD51 complex	6	BRE, BRCA2, MSH2, BLM, MSH6, BRCC3
BRCA2	BARD1	Yes	BRCA1-BARD1-BRCA2-DNA damage complex III	1	BRCA1
BRCA2	TP53	No	-	2	BARD1, RAD51
BRCA2	ESR1	No	-	1	HDAC2
BRCA2	RAD51	Yes	BRCC complex	3	BRCA1, BRE, BRCC3
BARD1	TP53	Yes	P53-BARD1-Ku70 complex	3	MSH6, XRCC6, TP53
BARD1	ESR1	No	-	1	TP53
BARD1	RAD51	No	-	4	BRCA1, BRCA2, MSH6, TP53
TP53	ESR1	Yes	Er-alpha-p53-hdm2 complex	3	SP1, TP53, MDM2
TP53	RAD51	Yes	MSH2/6-BLM-p53-RAD51 complex	4	MSH6, BLM, MSH2, TP53
ESR1	CASP8	No	-	1	CHUK
ESR1	RAD51	No	-	1	TP53
ESR1	PIK3CA	No	-	1	PIK3R1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
BRIP1	FAM175A	No	1	BRCA1
BRIP1	BRCA1	Yes	2	BRCA1, BRIP1
BRIP1	BARD1	No	1	BRCA1
FAM175A	BRCA1	Yes	2	FAM175A, BRCA1
FAM175A	BARD1	No	1	BRCA1
BRCA1	BARD1	Yes	2	BRCA1, BARD1
BRCA2	PALB2	Yes	2	PALB2, BRCA2
BRCA2	RAD51	Yes	2	BRCA2, RAD51
PALB2	RAD51	No	1	BRCA2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

Gene1	Gene2	Direct interaction	More information
CHEK2	TP53	yes, they interact	TP53 is phosphorylated on Ser-20 by CHEK2 in response to DNA damage. [UniProt]

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Pathways in cancer	hsa05200	3.98	8	KRAS, BRCA2, CASP8, PIK3CA, CDH1, TP53, AKT1, RAD51
Pancreatic cancer	hsa05212	6.56	6	BRCA2, TP53, KRAS, PIK3CA, AKT1, RAD51
HTLV-I infection	hsa05166	4.59	6	ATM, TP53, KRAS, PIK3CA, AKT1, CHEK2
Melanoma	hsa05218	6.56	5	TP53, KRAS, AKT1, PIK3CA, CDH1
Fanconi anemia pathway	hsa03460	7.01	5	BRCA2, BRCA1, BRIP1, PALB2, RAD51
Proteoglycans in cancer	hsa05205	5.02	5	TP53, ESR1, KRAS, AKT1, PIK3CA
Endometrial cancer	hsa05213	6.81	5	TP53, KRAS, AKT1, CDH1, PIK3CA
MicroRNAs in cancer	hsa05206	5.38	5	ATM, BRCA1, KRAS, TP53, PIK3CA
p53 signaling pathway	hsa04115	6.56	5	ATM, CHEK2, PPM1D, CASP8, TP53
Homologous recombination	hsa03440	7.91	5	NBN, RAD54L, BRCA2, RAD51, XRCC3
Apoptosis	hsa04210	6.23	5	ATM, CASP8, TP53, AKT1, PIK3CA
Thyroid hormone signaling pathway	hsa04919	5.82	5	TP53, KRAS, ESR1, AKT1, PIK3CA
Hepatitis B	hsa05161	5.52	5	KRAS, CASP8, TP53, AKT1, PIK3CA
PI3K-Akt signaling pathway	hsa04151	4.21	5	TP53, BRCA1, KRAS, AKT1, PIK3CA
Colorectal cancer	hsa05210	6.52	4	KRAS, TP53, AKT1, PIK3CA
Estrogen signaling pathway	hsa04915	6.11	4	ESR1, KRAS, AKT1, PIK3CA
Glioma	hsa05214	6.66	4	TP53, AKT1, KRAS, PIK3CA
Prostate cancer	hsa05215	6.11	4	KRAS, TP53, AKT1, PIK3CA
Rap1 signaling pathway	hsa04015	4.97	4	KRAS, AKT1, PIK3CA, CDH1
Neurotrophin signaling pathway	hsa04722	5.78	4	KRAS, TP53, AKT1, PIK3CA
Central carbon metabolism in cancer	hsa05230	6.7	4	TP53, KRAS, AKT1, PIK3CA
Viral carcinogenesis	hsa05203	5.08	4	KRAS, CASP8, TP53, PIK3CA
FoxO signaling pathway	hsa04068	5.63	4	ATM, AKT1, KRAS, PIK3CA
Chronic myeloid leukemia	hsa05220	6.48	4	TP53, KRAS, AKT1, PIK3CA
Non-small cell lung cancer	hsa05223	6.88	4	TP53, AKT1, KRAS, PIK3CA
Hepatitis C	hsa05160	5.68	4	TP53, KRAS, AKT1, PIK3CA
Prolactin signaling pathway	hsa04917	6.6	4	KRAS, ESR1, AKT1, PIK3CA
Signaling pathways regulating pluripotency of stem cells	hsa04550	5.6	3	AKT1, KRAS, PIK3CA
Bladder cancer	hsa05219	7.38	3	KRAS, TP53, CDH1
Progesterone-mediated oocyte maturation	hsa04914	6.18	3	AKT1, KRAS, PIK3CA
Renal cell carcinoma	hsa05211	6.6	3	AKT1, KRAS, PIK3CA
Thyroid cancer	hsa05216	7.48	3	KRAS, TP53, CDH1
Cholinergic synapse	hsa04725	5.88	3	KRAS, AKT1, PIK3CA
Choline metabolism in cancer	hsa05231	6.09	3	KRAS, AKT1, PIK3CA
Chemokine signaling pathway	hsa04062	5.19	3	KRAS, AKT1, PIK3CA
Chagas disease (American trypanosomiasis)	hsa05142	5.99	3	AKT1, CASP8, PIK3CA
Epstein-Barr virus infection	hsa05169	4.97	3	AKT1, TP53, PIK3CA
Toxoplasmosis	hsa05145	5.71	3	CASP8, AKT1, PIK3CA
Measles	hsa05162	5.6	3	TP53, AKT1, PIK3CA
VEGF signaling pathway	hsa04370	6.77	3	KRAS, AKT1, PIK3CA
Cell cycle	hsa04110	5.68	3	ATM, CHEK2, TP53
Toll-like receptor signaling pathway	hsa04620	6.0	3	CASP8, AKT1, PIK3CA
T cell receptor signaling pathway	hsa04660	6.01	3	KRAS, AKT1, PIK3CA
Insulin signaling pathway	hsa04910	5.55	3	KRAS, PIK3CA, AKT1
Ras signaling pathway	hsa04014	4.9	3	KRAS, PIK3CA, AKT1
Fc epsilon RI signaling pathway	hsa04664	6.6	3	KRAS, AKT1, PIK3CA
Small cell lung cancer	hsa05222	6.17	3	TP53, AKT1, PIK3CA
Acute myeloid leukemia	hsa05221	6.74	3	KRAS, PIK3CA, AKT1
MAPK signaling pathway	hsa04010	4.63	3	KRAS, TP53, AKT1
TNF signaling pathway	hsa04668	5.96	3	CASP8, AKT1, PIK3CA
Non-alcoholic fatty liver disease (NAFLD)	hsa04932	5.51	3	CASP8, AKT1, PIK3CA
B cell receptor signaling pathway	hsa04662	6.52	3	AKT1, KRAS, PIK3CA
ErbB signaling pathway	hsa04012	6.15	3	KRAS, PIK3CA, AKT1
Platelet activation	hsa04611	5.66	2	PIK3CA, AKT1
cGMP-PKG signaling pathway	hsa04022	5.32	2	AKT1, PIK3CA
Natural killer cell mediated cytotoxicity	hsa04650	5.53	2	KRAS, PIK3CA
cAMP signaling pathway	hsa04024	5.05	2	PIK3CA, AKT1
Jak-STAT signaling pathway	hsa04630	5.44	2	AKT1, PIK3CA
Tight junction	hsa04530	5.53	2	KRAS, AKT1
Focal adhesion	hsa04510	4.92	2	PIK3CA, AKT1
Osteoclast differentiation	hsa04380	5.64	2	PIK3CA, AKT1
HIF-1 signaling pathway	hsa04066	5.9	2	AKT1, PIK3CA
Oxytocin signaling pathway	hsa04921	5.4	2	KRAS, PIK3CA
Aldosterone-regulated sodium reabsorption	hsa04960	7.41	2	KRAS, PIK3CA
Herpes simplex infection	hsa05168	5.08	2	CASP8, TP53
Influenza A	hsa05164	5.21	2	AKT1, PIK3CA
Bacterial invasion of epithelial cells	hsa05100	6.34	2	PIK3CA, CDH1
Transcriptional misregulation in cancer	hsa05202	5.21	2	ATM, TP53
Fc gamma R-mediated phagocytosis	hsa04666	6.21	2	PIK3CA, AKT1
AMPK signaling pathway	hsa04152	5.8	2	AKT1, PIK3CA
mTOR signaling pathway	hsa04150	6.72	2	AKT1, PIK3CA
Regulation of actin cytoskeleton	hsa04810	4.9	2	KRAS, PIK3CA
Carbohydrate digestion and absorption	hsa04973	7.28	2	PIK3CA, AKT1
Tuberculosis	hsa05152	5.17	2	CASP8, AKT1
Huntington's disease	hsa05016	5.17	2	CASP8, TP53
Adrenergic signaling in cardiomyocytes	hsa04261	5.44	2	AKT1, PIK3CA

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Salmonella infection (hsa05132)	NEW	6.29	0.002	ESR1, CASP8, CDH1, TP53, AKT1, PIK3CA
Melanoma (hsa05218)	-	6.56	0.0	ESR1, TP53, CDH1, KRAS, AKT1, PIK3CA
Bladder cancer (hsa05219)	-	7.38	0.003	TP53, KRAS, AKT1, CDH1
Progesterone-mediated oocyte maturation (hsa04914)	-	6.18	0.0	KRAS, ESR1, CDH1, TP53, AKT1, PIK3CA, BRCA1
Pancreatic cancer (hsa05212)	-	6.56	0.0	KRAS, BRCA2, ESR1, TP53, PIK3CA, AKT1, RAD51
Natural killer cell mediated cytotoxicity (hsa04650)	-	5.53	0.009	ESR1, CASP8, KRAS, TP53, AKT1, PIK3CA
Colorectal cancer (hsa05210)	-	6.52	0.002	TP53, KRAS, ESR1, AKT1, PIK3CA
Estrogen signaling pathway (hsa04915)	-	6.11	0.024	ATM, ESR1, KRAS, AKT1, PIK3CA
Thyroid cancer (hsa05216)	-	7.48	0.002	TP53, ESR1, KRAS, CDH1
Signaling pathways regulating pluripotency of stem cells (hsa04550)	-	5.6	0.0	KRAS, ESR1, CDH1, TP53, AKT1, PIK3CA, BRCA1, CHEK2
Glioma (hsa05214)	-	6.66	0.005	TP53, KRAS, ESR1, AKT1, PIK3CA
Prostate cancer (hsa05215)	-	6.11	0.011	TP53, KRAS, ESR1, AKT1, PIK3CA
Lipid metabolism	NEW	4.16	0.036	ATM, KRAS, AKT1, CASP8, BARD1, TP53, PIK3CA, ESR1, BRCA1
Excretory system	NEW	5.45	0.027	ATM, ESR1, KRAS, TP53, AKT1, PIK3CA
Central carbon metabolism in cancer (hsa05230)	-	6.7	0.001	TP53, KRAS, AKT1, PIK3CA, CDH1
Choline metabolism in cancer (hsa05231)	-	6.09	0.042	ATM, TP53, KRAS, AKT1, PIK3CA
FoxO signaling pathway (hsa04068)	-	5.63	0.0	ATM, KRAS, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1
Chemokine signaling pathway (hsa04062)	-	5.19	0.007	ATM, KRAS, ESR1, CDH1, TP53, AKT1, PIK3CA
Thyroid hormone signaling pathway (hsa04919)	-	5.82	0.003	ATM, KRAS, ESR1, TP53, PIK3CA, AKT1, BRCA1
Endometrial cancer (hsa05213)	-	6.81	0.0	ESR1, TP53, CDH1, KRAS, AKT1, PIK3CA
Inflammatory mediator regulation of TRP channels (hsa04750)	NEW	6.07	0.041	ATM, ESR1, TP53, AKT1, PIK3CA
Chagas disease (American trypanosomiasis) (hsa05142)	-	5.99	0.003	ATM, ESR1, CASP8, TP53, PIK3CA, AKT1
Replication and repair	NEW	5.41	0.0	ATM, NBN, BRCA2, XRCC3, PALB2, TP53, ESR1, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
Amoebiasis (hsa05146)	NEW	5.82	0.01	ATM, CASP8, CDH1, RB1CC1, PIK3CA, AKT1
Infectious diseases: Parasitic	NEW	4.46	0.015	ATM, KRAS, ESR1, CASP8, TP53, CDH1, RB1CC1, PIK3CA, AKT1
Toxoplasmosis (hsa05145)	-	5.71	0.01	ESR1, CASP8, KRAS, TP53, AKT1, PIK3CA
Herpes simplex infection (hsa05168)	-	5.08	0.0	ATM, KRAS, ESR1, CASP8, PPM1D, TP53, CDH1, AKT1, CHEK2
HTLV-I infection (hsa05166)	-	4.59	0.016	ATM, KRAS, BRCA2, AKT1, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2
Hepatitis C (hsa05160)	-	5.68	0.001	KRAS, ESR1, PPM1D, CDH1, TP53, AKT1, PIK3CA
Hepatitis B (hsa05161)	-	5.52	0.008	KRAS, ESR1, CASP8, CDH1, TP53, AKT1, PIK3CA
Measles (hsa05162)	-	5.6	0.001	ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1, BRCA1
Apoptosis (hsa04210)	-	6.23	0.001	ATM, CASP8, TP53, AKT1, PIK3CA
Cancers: Overview	NEW	2.72	0.002	ATM, NBN, KRAS, BRCA2, AKT1, CASP8, PPM1D, BARD1, TP53, PHB, CDH1, PIK3CA, ESR1, BRCA1, BRIP1, CHEK2, RAD51
Cancers: Specific types	NEW	4.1	0.013	NBN, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, RAD51
Proteoglycans in cancer (hsa05205)	-	5.02	0.04	KRAS, ESR1, CDH1, TP53, AKT1, PIK3CA, BRCA1
Cell cycle (hsa04110)	-	5.68	0.0	ATM, BARD1, CDH1, TP53, ESR1, BRCA1, CHEK2
MicroRNAs in cancer (hsa05206)	-	5.38	0.013	ATM, KRAS, ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1
Toll-like receptor signaling pathway (hsa04620)	-	6.0	0.029	CASP8, ESR1, TP53, AKT1, PIK3CA
Pathways in cancer (hsa05200)	-	3.98	0.002	ATM, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, RAD51
Oocyte meiosis (hsa04114)	NEW	5.91	0.002	ATM, ESR1, PPM1D, TP53, AKT1, BRCA1
p53 signaling pathway (hsa04115)	-	6.56	0.0	ATM, CASP8, PPM1D, TP53, CHEK2, BRCA1
T cell receptor signaling pathway (hsa04660)	-	6.01	0.031	KRAS, CASP8, AKT1, ESR1, PIK3CA
Homologous recombination (hsa03440)	-	7.91	0.0	NBN, BRCA2, XRCC3, CHEK2, RAD54L, RAD51
Insulin signaling pathway (hsa04910)	-	5.55	0.028	ESR1, KRAS, TP53, AKT1, PIK3CA, BRCA1
Transport and catabolism	NEW	3.49	0.016	ATM, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, CHEK2, TSG101
Non-small cell lung cancer (hsa05223)	-	6.88	0.002	AKT1, TP53, ESR1, KRAS, PIK3CA
Prolactin signaling pathway (hsa04917)	-	6.6	0.005	TP53, KRAS, ESR1, AKT1, PIK3CA
Acute myeloid leukemia (hsa05221)	-	6.74	0.027	KRAS, ESR1, AKT1, PIK3CA
Chronic myeloid leukemia (hsa05220)	-	6.48	0.0	ESR1, TP53, CDH1, KRAS, AKT1, PIK3CA
Viral carcinogenesis (hsa05203)	-	5.08	0.0	ATM, PHB, KRAS, AKT1, CASP8, TP53, PIK3CA, ESR1, BRCA1
Fanconi anemia pathway (hsa03460)	-	7.01	0.0	BRCA2, PALB2, BRCA1, BRIP1, CHEK2, RAD51
Type II diabetes mellitus (hsa04930)	NEW	7.12	0.018	ESR1, TP53, AKT1, PIK3CA
Cell growth and death	NEW	4.41	0.0	ATM, AKT1, CASP8, PPM1D, BARD1, PIK3CA, CDH1, TP53, ESR1, BRCA1, CHEK2
Genetic Information Processing	NEW	2.48	0.0	ATM, NBN, XRCC3, BRCA2, AKT1, PPM1D, PALB2, BARD1, TP53, PHB, CDH1, RB1CC1, PIK3CA, ESR1, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
MAPK signaling pathway (hsa04010)	-	4.63	0.016	ATM, KRAS, ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1
NOD-like receptor signaling pathway (hsa04621)	NEW	6.88	0.041	TP53, CASP8, AKT1, TSG101
Alcoholism (hsa05034)	NEW	5.59	0.02	ATM, NBN, ESR1, KRAS, PIK3CA, AKT1
Tuberculosis (hsa05152)	-	5.17	0.024	KRAS, ESR1, CASP8, TP53, PIK3CA, AKT1, CHEK2
Fc epsilon RI signaling pathway (hsa04664)	-	6.6	0.036	TP53, KRAS, AKT1, PIK3CA

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Cell Cycle	R-HSA-1640170	3.89	9	ATM, NBN, BRCA2, BARD1, TP53, FAM175A, BRCA1, CHEK2, RAD51
Signal Transduction	R-HSA-162582	1.78	8	PHB, KRAS, ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1
Cell Cycle Checkpoints	R-HSA-69620	5.64	7	ATM, NBN, BARD1, TP53, FAM175A, BRCA1, CHEK2
DNA Repair	R-HSA-73894	5.8	7	ATM, NBN, BRCA2, PALB2, BRCA1, BRIP1, RAD51
G2/M Checkpoints	R-HSA-69481	6.46	6	ATM, NBN, BARD1, FAM175A, BRCA1, CHEK2
Homologous recombination repair of replication-independent double-strand breaks	R-HSA-73951	8.98	6	ATM, NBN, BRCA2, BRCA1, BRIP1, RAD51
G2/M DNA damage checkpoint	R-HSA-69473	7.15	6	ATM, NBN, BARD1, FAM175A, BRCA1, CHEK2
Immune System	R-HSA-168256	2.37	6	PHB, CASP8, KRAS, CDH1, AKT1, PIK3CA
Homologous Recombination Repair	R-HSA-73888	8.98	6	ATM, NBN, BRCA2, BRCA1, BRIP1, RAD51
Double-Strand Break Repair	R-HSA-73890	8.46	6	ATM, NBN, BRCA2, BRCA1, BRIP1, RAD51
Meiosis	R-HSA-1500620	6.59	5	ATM, NBN, BRCA1, BRCA2, RAD51
Innate Immune System	R-HSA-168249	3.17	5	PHB, CASP8, KRAS, AKT1, PIK3CA
Meiotic recombination	R-HSA-912446	7.25	5	NBN, ATM, BRCA1, BRCA2, RAD51
Signaling by ERBB4	R-HSA-1236394	4.7	5	PHB, KRAS, AKT1, ESR1, PIK3CA
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85	4	PHB, KRAS, PIK3CA, AKT1
Programmed Cell Death	R-HSA-5357801	5.65	4	TP53, CASP8, AKT1, CDH1
IGF1R signaling cascade	R-HSA-2428924	4.85	4	PHB, AKT1, PIK3CA, KRAS
Downstream signal transduction	R-HSA-186763	4.65	4	PHB, AKT1, KRAS, PIK3CA
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85	4	PHB, AKT1, KRAS, PIK3CA
Signaling by Insulin receptor	R-HSA-74752	4.73	4	PHB, AKT1, KRAS, PIK3CA
Adaptive Immune System	R-HSA-1280218	3.19	4	KRAS, AKT1, PIK3CA, CDH1
Disease	R-HSA-1643685	3.33	4	KRAS, AKT1, PIK3CA, TSG101
Insulin receptor signalling cascade	R-HSA-74751	4.85	4	PHB, KRAS, PIK3CA, AKT1
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71	4	PHB, AKT1, PIK3CA, KRAS
Signalling by NGF	R-HSA-166520	4.23	4	PHB, AKT1, KRAS, PIK3CA
Signaling by VEGF	R-HSA-194138	4.66	4	PHB, KRAS, PIK3CA, AKT1
Cellular responses to stress	R-HSA-2262752	4.56	4	ATM, NBN, RB1CC1, TP53
IRS-mediated signalling	R-HSA-112399	4.87	4	PHB, KRAS, PIK3CA, AKT1
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71	4	PHB, KRAS, AKT1, PIK3CA
Signaling by FGFR4	R-HSA-5654743	4.69	4	PHB, AKT1, KRAS, PIK3CA
Signaling by FGFR3	R-HSA-5654741	4.69	4	PHB, KRAS, AKT1, PIK3CA
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	4	PHB, AKT1, PIK3CA, KRAS
Signaling by FGFR	R-HSA-190236	4.67	4	PHB, AKT1, KRAS, PIK3CA
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03	4	PHB, KRAS, PIK3CA, AKT1
Signaling by SCF-KIT	R-HSA-1433557	4.73	4	PHB, KRAS, AKT1, PIK3CA
Signaling by PDGF	R-HSA-186797	4.53	4	PHB, KRAS, AKT1, PIK3CA
DAP12 signaling	R-HSA-2424491	4.64	4	PHB, AKT1, KRAS, PIK3CA
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71	4	PHB, KRAS, PIK3CA, AKT1
Signaling by EGFR	R-HSA-177929	4.59	4	PHB, KRAS, PIK3CA, AKT1
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51	4	PHB, KRAS, AKT1, PIK3CA
Fanconi Anemia pathway	R-HSA-419524	8.4	4	ATM, BRCA1, BRCA2, PALB2
Signaling by GPCR	R-HSA-372790	2.68	4	PHB, KRAS, AKT1, PIK3CA
Signaling by FGFR2	R-HSA-5654738	4.68	4	PHB, AKT1, KRAS, PIK3CA
Signaling by FGFR1	R-HSA-5654736	4.69	4	PHB, KRAS, AKT1, PIK3CA
DAP12 interactions	R-HSA-2172127	4.56	4	PHB, KRAS, AKT1, PIK3CA
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71	4	PHB, AKT1, KRAS, PIK3CA
Signaling by ERBB2	R-HSA-1227986	4.66	4	PHB, KRAS, AKT1, PIK3CA
Metabolism	R-HSA-1430728	2.34	4	AKT1, BRIP1, PIK3CA, HMMR
Hemostasis	R-HSA-109582	3.98	4	TP53, KRAS, AKT1, PIK3CA
Apoptosis	R-HSA-109581	5.68	4	TP53, CASP8, AKT1, CDH1
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.59	3	AKT1, KRAS, PIK3CA
Diseases of signal transduction	R-HSA-5663202	4.89	3	KRAS, PIK3CA, AKT1
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	7.15	3	ATM, NBN, TP53
Cellular Senescence	R-HSA-2559583	5.7	3	ATM, NBN, TP53
Signaling by Interleukins	R-HSA-449147	4.71	3	PHB, KRAS, PIK3CA
Generic Transcription Pathway	R-HSA-212436	3.86	3	ESR1, TP53, AKT1
Gene Expression	R-HSA-74160	2.72	3	ESR1, TP53, AKT1
Interleukin receptor SHC signaling	R-HSA-912526	5.09	3	PHB, KRAS, PIK3CA
Interleukin-2 signaling	R-HSA-451927	5.05	3	PHB, KRAS, PIK3CA
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.62	3	KRAS, AKT1, PIK3CA
ATM mediated response to DNA double-strand break	R-HSA-83542	10.66	3	ATM, NBN, BRCA1
G1/S DNA Damage Checkpoints	R-HSA-69615	7.08	3	ATM, CHEK2, TP53
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	3	PHB, KRAS, PIK3CA
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99	3	PHB, KRAS, PIK3CA
Recruitment of repair and signaling proteins to double-strand breaks	R-HSA-75154	9.98	3	ATM, NBN, BRCA1
ATM mediated phosphorylation of repair proteins	R-HSA-75148	10.66	3	ATM, NBN, BRCA1
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26	3	PHB, KRAS, PIK3CA
Intrinsic Pathway for Apoptosis	R-HSA-109606	7.73	3	CASP8, TP53, AKT1
Homologous DNA Pairing and Strand Exchange	R-HSA-76010	10.18	3	BRCA2, BRIP1, RAD51
Developmental Biology	R-HSA-1266738	3.48	3	PHB, KRAS, AKT1
PI-3K cascade:FGFR4	R-HSA-5654720	6.37	2	PIK3CA, AKT1
Transcriptional Regulation by TP53	R-HSA-3700989	6.73	2	TP53, AKT1
FCERI mediated MAPK activation	R-HSA-2871796	4.32	2	PHB, KRAS
NCAM signaling for neurite out-growth	R-HSA-375165	4.9	2	PHB, KRAS
PI3K/AKT activation	R-HSA-198203	6.32	2	AKT1, PIK3CA
Signaling by FGFR3 in disease	R-HSA-5655332	8.52	2	KRAS, PIK3CA
GPVI-mediated activation cascade	R-HSA-114604	7.18	2	AKT1, PIK3CA
Signaling by Leptin	R-HSA-2586552	5.1	2	PHB, KRAS
Frs2-mediated activation	R-HSA-170968	5.12	2	PHB, KRAS
PI3K events in ERBB2 signaling	R-HSA-1963642	6.37	2	PIK3CA, AKT1
Cell surface interactions at the vascular wall	R-HSA-202733	6.32	2	KRAS, PIK3CA
Cell-Cell communication	R-HSA-1500931	5.87	2	PIK3CA, CDH1
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	4.95	2	AKT1, PIK3CA
GAB1 signalosome	R-HSA-180292	6.31	2	AKT1, PIK3CA
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14	2	PHB, KRAS
RAF activation	R-HSA-5673000	8.34	2	PHB, KRAS
RAF/MAP kinase cascade	R-HSA-5673001	5.15	2	PHB, KRAS
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	8.73	2	KRAS, PIK3CA
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	R-HSA-69601	7.28	2	ATM, CHEK2
MAPK family signaling cascades	R-HSA-5683057	4.89	2	PHB, KRAS
PIP3 activates AKT signaling	R-HSA-1257604	6.37	2	AKT1, PIK3CA
PI3K Cascade	R-HSA-109704	6.68	2	AKT1, PIK3CA
Apoptotic cleavage of cellular proteins	R-HSA-111465	7.73	2	CASP8, CDH1
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11	2	PHB, KRAS
PI-3K cascade:FGFR1	R-HSA-5654689	6.37	2	PIK3CA, AKT1
Presynaptic phase of homologous DNA pairing and strand exchange	R-HSA-76003	10.4	2	BRCA2, RAD51
SHC1 events in EGFR signaling	R-HSA-180336	5.15	2	PHB, KRAS
p53-Dependent G1 DNA Damage Response	R-HSA-69563	7.15	2	ATM, TP53
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14	2	PHB, KRAS
SOS-mediated signalling	R-HSA-112412	5.15	2	PHB, KRAS
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14	2	PHB, KRAS
Constitutive Signaling by EGFRvIII	R-HSA-5637810	9.08	2	KRAS, PIK3CA
CD28 co-stimulation	R-HSA-389356	7.98	2	PIK3CA, AKT1
Signaling by EGFRvIII in Cancer	R-HSA-5637812	9.08	2	KRAS, PIK3CA
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	7.15	2	ATM, TP53
Signaling by EGFR in Cancer	R-HSA-1643713	8.73	2	KRAS, PIK3CA
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	7.31	2	ATM, TP53
Signaling by FGFR in disease	R-HSA-1226099	7.49	2	KRAS, PIK3CA
C-type lectin receptors (CLRs)	R-HSA-5621481	6.06	2	KRAS, CASP8
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.56	2	PIK3CA, AKT1
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15	2	PHB, KRAS
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.59	2	AKT1, PIK3CA
Signaling by FGFR1 in disease	R-HSA-5655302	7.81	2	KRAS, PIK3CA
Membrane Trafficking	R-HSA-199991	5.26	2	AKT1, TSG101
Activation of BH3-only proteins	R-HSA-114452	8.34	2	TP53, AKT1
Signalling to RAS	R-HSA-167044	5.08	2	PHB, KRAS
GPCR downstream signaling	R-HSA-388396	3.07	2	PIK3CA, AKT1
PI-3K cascade:FGFR2	R-HSA-5654695	6.37	2	PIK3CA, AKT1
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	8.73	2	KRAS, PIK3CA
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.73	2	TP53, AKT1
Vesicle-mediated transport	R-HSA-5653656	4.33	2	AKT1, TSG101
Prolonged ERK activation events	R-HSA-169893	5.11	2	PHB, KRAS
Apoptotic execution phase	R-HSA-75153	7.28	2	CASP8, CDH1
Signalling to ERKs	R-HSA-187687	5.04	2	PHB, KRAS
Stabilization of p53	R-HSA-69541	7.28	2	ATM, TP53
GRB2 events in EGFR signaling	R-HSA-179812	5.15	2	PHB, KRAS
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15	2	PHB, KRAS
PI3K events in ERBB4 signaling	R-HSA-1250342	6.37	2	AKT1, PIK3CA
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.4	2	AKT1, PIK3CA
G-protein beta:gamma signalling	R-HSA-397795	7.31	2	AKT1, PIK3CA
ARMS-mediated activation	R-HSA-170984	5.12	2	PHB, KRAS
PI-3K cascade:FGFR3	R-HSA-5654710	6.37	2	PIK3CA, AKT1
Signaling by FGFR4 in disease	R-HSA-5655291	9.52	2	KRAS, PIK3CA
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14	2	PHB, KRAS
Tie2 Signaling	R-HSA-210993	8.81	2	KRAS, PIK3CA
p53-Independent DNA Damage Response	R-HSA-69610	7.28	2	ATM, CHEK2
p53-Independent G1/S DNA damage checkpoint	R-HSA-69613	7.28	2	ATM, CHEK2
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15	2	PHB, KRAS
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12	2	PHB, KRAS
Axon guidance	R-HSA-422475	3.93	2	PHB, KRAS
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07	2	PHB, KRAS
Signaling by FGFR2 in disease	R-HSA-5655253	8.23	2	KRAS, PIK3CA
Platelet activation, signaling and aggregation	R-HSA-76002	5.15	2	PIK3CA, AKT1
Costimulation by the CD28 family	R-HSA-388841	6.56	2	PIK3CA, AKT1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Signaling by FGFR3 in disease (R-HSA-5655332)	-	8.52	0.018	KRAS, PIK3CA, CDH1
Cellular responses to stress (R-HSA-2262752)	-	4.56	0.023	ATM, NBN, CASP8, TP53, RB1CC1, CDH1, AKT1, BRCA1, CHEK2
Recruitment of repair and signaling proteins to double-strand breaks (R-HSA-75154)	-	9.98	0.0	ATM, NBN, BRCA1
Cell Cycle (R-HSA-1640170)	-	3.89	0.0	ATM, NBN, BRCA2, AKT1, PPM1D, BARD1, TP53, FAM175A, ESR1, BRCA1, CHEK2, RAD51
Homologous recombination repair of replication-independent double-strand breaks (R-HSA-73951)	-	8.98	0.0	ATM, NBN, BRCA2, BRCA1, BRIP1, RAD51
RAF activation (R-HSA-5673000)	-	8.34	0.04	PHB, KRAS, AKT1
G2/M DNA damage checkpoint (R-HSA-69473)	-	7.15	0.0	ATM, NBN, BARD1, FAM175A, BRCA1, CHEK2
Presynaptic phase of homologous DNA pairing and strand exchange (R-HSA-76003)	-	10.4	0.03	BRCA2, RAD51
Phospholipid metabolism (R-HSA-1483257)	NEW	5.83	0.002	ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1, BRCA1
ATM mediated response to DNA double-strand break (R-HSA-83542)	-	10.66	0.0	ATM, NBN, BRCA1
Cell Cycle Checkpoints (R-HSA-69620)	-	5.64	0.0	ATM, NBN, BARD1, TP53, FAM175A, BRCA1, CHEK2, RAD51
Homologous Recombination Repair (R-HSA-73888)	-	8.98	0.0	ATM, NBN, BRCA2, BRCA1, BRIP1, RAD51
FGFR1 mutant receptor activation (R-HSA-1839124)	NEW	8.12	0.005	ESR1, AKT1, PIK3CA, CDH1
Signaling by FGFR in disease (R-HSA-1226099)	-	7.49	0.001	AKT1, KRAS, ESR1, PIK3CA, CDH1
MAP kinase activation in TLR cascade (R-HSA-450294)	NEW	7.28	0.022	ATM, CASP8, TP53, AKT1
Signaling by FGFR1 in disease (R-HSA-5655302)	-	7.81	0.0	KRAS, ESR1, AKT1, CDH1, PIK3CA
NCAM signaling for neurite out-growth (R-HSA-375165)	-	4.9	0.031	PHB, KRAS, ESR1, CDH1, RB1CC1, TP53, AKT1, PIK3CA
ATM mediated phosphorylation of repair proteins (R-HSA-75148)	-	10.66	0.0	ATM, NBN, BRCA1
Fanconi Anemia pathway (R-HSA-419524)	-	8.4	0.0	ATM, BRCA1, BRCA2, PALB2
G2/M Checkpoints (R-HSA-69481)	-	6.46	0.0	ATM, NBN, BARD1, TP53, FAM175A, BRCA1, CHEK2
RHO GTPase Effectors (R-HSA-195258)	NEW	4.94	0.003	KRAS, ESR1, PPM1D, RAD51, TP53, CDH1, PIK3CA, AKT1, TSG101
Signaling by FGFR2 in disease (R-HSA-5655253)	-	8.23	0.034	KRAS, PIK3CA, CDH1
Homologous DNA Pairing and Strand Exchange (R-HSA-76010)	-	10.18	0.0	BRCA2, BRIP1, RAD51
Meiotic recombination (R-HSA-912446)	-	7.25	0.0	ATM, NBN, BRCA2, TP53, BRCA1, RAD51
Meiosis (R-HSA-1500620)	-	6.59	0.001	ATM, NBN, BRCA2, TP53, BRCA1, RAD51
DNA Repair (R-HSA-73894)	-	5.8	0.0	ATM, NBN, BRCA2, PALB2, TP53, ESR1, BRCA1, BRIP1, RAD51
Intrinsic Pathway for Apoptosis (R-HSA-109606)	-	7.73	0.039	CASP8, TP53, AKT1
Double-Strand Break Repair (R-HSA-73890)	-	8.46	0.0	ATM, NBN, BRCA2, BRCA1, BRIP1, RAD51

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	26	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, SLC22A18, BARD1, CDH1, AKT1, BRIP1, HMMR, BRCA2, NQO2, RAD51, ESR1, CHEK2, TSG101
protein binding (GO:0005515)	0.46	26	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, SLC22A18, BARD1, CDH1, AKT1, BRIP1, HMMR, BRCA2, NQO2, RAD51, ESR1, CHEK2, TSG101
organic cyclic compound binding (GO:0097159)	1.05	18	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, PALB2, BARD1, TP53, RAD51, ESR1, PIK3CA, NBN, CHEK2, RAD54L, BRIP1, BRCA1, TSG101
heterocyclic compound binding (GO:1901363)	1.06	18	ATM, PHB, XRCC3, KRAS, BRCA2, AKT1, PALB2, BARD1, TP53, RAD51, ESR1, PIK3CA, NBN, CHEK2, RAD54L, BRIP1, BRCA1, TSG101
catalytic activity (GO:0003824)	1.05	16	ATM, NBN, KRAS, BRCA2, XRCC3, CASP8, PPM1D, BARD1, PIK3CA, NQO2, AKT1, CHEK2, BRCA1, BRIP1, RAD54L, RAD51
enzyme binding (GO:0019899)	2.27	14	PHB, SLC22A18, BRCA2, AKT1, CASP8, BARD1, PPM1D, TP53, RB1CC1, RAD51, ESR1, BRCA1, CHEK2, TSG101
nucleic acid binding (GO:0003676)	1.44	14	PHB, ATM, BRCA2, ESR1, PALB2, BARD1, TP53, RAD51, XRCC3, NBN, BRCA1, BRIP1, RAD54L, TSG101
DNA binding (GO:0003677)	1.92	13	PHB, ATM, BRCA2, XRCC3, PALB2, TP53, RAD51, ESR1, NBN, RAD54L, BRIP1, BRCA1, TSG101
carbohydrate derivative binding (GO:0097367)	2.03	12	ATM, KRAS, XRCC3, RAD51, TP53, CDH1, PIK3CA, AKT1, RAD54L, BRIP1, CHEK2, HMMR
ion binding (GO:0043167)	1.36	11	KRAS, AKT1, PPM1D, BARD1, TP53, CDH1, NQO2, ESR1, BRCA1, BRIP1, CHEK2
cation binding (GO:0043169)	1.4	10	KRAS, PPM1D, BARD1, TP53, CDH1, NQO2, ESR1, BRCA1, BRIP1, CHEK2
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	10	ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
nucleotide binding (GO:0000166)	1.96	10	ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
small molecule binding (GO:0036094)	1.89	10	ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
ribonucleotide binding (GO:0032553)	2.19	10	ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
purine nucleoside binding (GO:0001883)	2.22	10	ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
ribonucleoside binding (GO:0032549)	2.22	10	ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
purine ribonucleotide binding (GO:0032555)	2.2	10	ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
purine nucleotide binding (GO:0017076)	2.19	10	ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
metal ion binding (GO:0046872)	1.41	10	KRAS, PPM1D, BARD1, TP53, CDH1, NQO2, ESR1, BRCA1, BRIP1, CHEK2
purine ribonucleoside binding (GO:0032550)	2.22	10	ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
nucleoside phosphate binding (GO:1901265)	1.96	10	ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
nucleoside binding (GO:0001882)	2.21	10	ATM, KRAS, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
adenyl ribonucleotide binding (GO:0032559)	2.41	9	ATM, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
ATP binding (GO:0005524)	2.43	9	ATM, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
adenyl nucleotide binding (GO:0030554)	2.4	9	ATM, XRCC3, PIK3CA, TP53, AKT1, RAD54L, BRIP1, CHEK2, RAD51
hydrolase activity (GO:0016787)	1.9	8	NBN, CASP8, PPM1D, KRAS, XRCC3, RAD54L, BRIP1, RAD51
identical protein binding (GO:0042802)	2.63	8	ESR1, CASP8, BARD1, TP53, RAD51, AKT1, CHEK2, TSG101
transferase activity (GO:0016740)	1.95	7	ATM, BRCA2, BARD1, PIK3CA, AKT1, BRCA1, CHEK2
macromolecular complex binding (GO:0044877)	2.61	7	ATM, CASP8, TP53, KRAS, ESR1, BRCA1, RAD51
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	6	NBN, KRAS, XRCC3, RAD54L, BRIP1, RAD51
ubiquitin protein ligase binding (GO:0031625)	4.17	6	SLC22A18, CASP8, TP53, CHEK2, BRCA1, TSG101
ubiquitin-like protein ligase binding (GO:0044389)	4.15	6	SLC22A18, CASP8, TP53, CHEK2, BRCA1, TSG101
pyrophosphatase activity (GO:0016462)	3.04	6	NBN, KRAS, XRCC3, RAD54L, BRIP1, RAD51
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	6	NBN, KRAS, XRCC3, RAD54L, BRIP1, RAD51
nucleoside-triphosphatase activity (GO:0017111)	3.09	6	NBN, KRAS, XRCC3, RAD54L, BRIP1, RAD51
kinase binding (GO:0019900)	3.32	6	PPM1D, BARD1, TP53, RB1CC1, AKT1, CHEK2
protein kinase binding (GO:0019901)	3.44	5	TP53, RB1CC1, PPM1D, CHEK2, AKT1
receptor binding (GO:0005102)	2.43	5	PHB, BRCA1, ESR1, CASP8, TP53
protein dimerization activity (GO:0046983)	2.72	5	ATM, CHEK2, BARD1, TP53, TSG101
transcription regulatory region DNA binding (GO:0044212)	3.03	4	PHB, BRCA1, ESR1, TP53
chromatin binding (GO:0003682)	3.64	4	BRCA1, ESR1, RAD51, TP53
transition metal ion binding (GO:0046914)	2.48	4	BRCA1, BARD1, ESR1, TP53
ATPase activity, coupled (GO:0042623)	3.97	4	NBN, BRIP1, RAD51, XRCC3
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	4	ATM, CHEK2, PIK3CA, AKT1
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	4	ATM, CHEK2, PIK3CA, AKT1
kinase activity (GO:0016301)	2.93	4	ATM, CHEK2, PIK3CA, AKT1
regulatory region nucleic acid binding (GO:0001067)	3.03	4	PHB, BRCA1, ESR1, TP53
protein serine/threonine kinase activity (GO:0004674)	3.64	4	ATM, CHEK2, PIK3CA, AKT1
zinc ion binding (GO:0008270)	2.66	4	BRCA1, BARD1, ESR1, TP53
ATPase activity (GO:0016887)	3.65	4	NBN, BRIP1, RAD51, XRCC3
regulatory region DNA binding (GO:0000975)	3.03	4	PHB, BRCA1, ESR1, TP53
protein complex binding (GO:0032403)	3.09	4	ATM, KRAS, CASP8, ESR1
protein kinase activity (GO:0004672)	3.27	4	ATM, CHEK2, AKT1, PIK3CA
double-stranded DNA binding (GO:0003690)	3.09	4	ESR1, RAD51, TP53, XRCC3
DNA-dependent ATPase activity (GO:0008094)	5.31	4	NBN, BRIP1, RAD51, XRCC3
enzyme regulator activity (GO:0030234)	2.85	3	AKT1, ESR1, PIK3CA
protein N-terminus binding (GO:0047485)	5.11	3	ATM, NBN, TP53
cytoskeletal protein binding (GO:0008092)	3.02	3	BRCA1, BRCA2, CDH1
transcription factor activity, sequence-specific DNA binding (GO:0003700)	2.65	3	PHB, ESR1, TP53
transcription factor binding (GO:0008134)	3.46	3	NBN, ESR1, TP53
damaged DNA binding (GO:0003684)	5.58	3	NBN, BRCA1, TP53
hydrolase activity, acting on ester bonds (GO:0016788)	3.1	3	PPM1D, RAD51, XRCC3
helicase activity (GO:0004386)	4.69	3	NBN, RAD54L, BRIP1
nucleic acid binding transcription factor activity (GO:0001071)	2.65	3	PHB, ESR1, TP53
molecular function regulator (GO:0098772)	2.51	3	ESR1, PIK3CA, AKT1
single-stranded DNA binding (GO:0003697)	5.17	3	BRCA2, RAD51, XRCC3
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981)	3.29	3	PHB, ESR1, TP53
protein homodimerization activity (GO:0042803)	3.16	3	CHEK2, BARD1, TSG101
protein C-terminus binding (GO:0008022)	4.5	2	PHB, RAD51
signal transducer activity (GO:0004871)	2.28	2	ESR1, CASP8
ATP-dependent helicase activity (GO:0008026)	5.12	2	NBN, BRIP1
ubiquitin-like protein binding (GO:0032182)	4.93	2	FAM175A, TSG101
GTPase activating protein binding (GO:0032794)	7.1	2	AKT1, CDH1
endodeoxyribonuclease activity (GO:0004520)	5.81	2	RAD51, XRCC3
phosphatidylinositol 3-kinase activity (GO:0035004)	5.49	2	ATM, PIK3CA
DNA helicase activity (GO:0003678)	5.73	2	NBN, BRIP1
G-protein coupled receptor binding (GO:0001664)	4.18	2	PHB, ESR1
ubiquitin-like protein transferase activity (GO:0019787)	3.69	2	BRCA1, BARD1
sequence-specific DNA binding (GO:0043565)	2.79	2	ESR1, TP53
structure-specific DNA binding (GO:0043566)	4.98	2	RAD51, XRCC3
sequence-specific double-stranded DNA binding (GO:1990837)	3.2	2	ESR1, TP53
ligase activity (GO:0016874)	3.72	2	BRCA1, BARD1
transcription coactivator activity (GO:0003713)	4.04	2	BRCA1, TSG101
transcription cofactor activity (GO:0003712)	3.44	2	BRCA1, TSG101
transcription factor activity, transcription factor binding (GO:0000989)	3.36	2	BRCA1, TSG101
transcription factor activity, protein binding (GO:0000988)	3.35	2	BRCA1, TSG101
1-phosphatidylinositol-3-kinase activity (GO:0016303)	5.98	2	ATM, PIK3CA
deoxyribonuclease activity (GO:0004536)	5.48	2	RAD51, XRCC3
tubulin binding (GO:0015631)	4.1	2	BRCA1, BRCA2
protease binding (GO:0002020)	5.08	2	BRCA2, TP53
ATP-dependent DNA helicase activity (GO:0004003)	6.13	2	NBN, BRIP1
nitric-oxide synthase regulator activity (GO:0030235)	7.79	2	ESR1, AKT1
DNA secondary structure binding (GO:0000217)	6.6	2	RAD51, XRCC3
lipid binding (GO:0008289)	3.26	2	ESR1, AKT1
beta-catenin binding (GO:0008013)	5.3	2	ESR1, CDH1
protein phosphatase binding (GO:0019903)	4.93	2	TP53, AKT1
phosphatase binding (GO:0019902)	4.63	2	TP53, AKT1
protein domain specific binding (GO:0019904)	3.32	2	KRAS, CASP8
core promoter binding (GO:0001047)	4.71	2	ESR1, TP53
core promoter sequence-specific DNA binding (GO:0001046)	5.12	2	ESR1, TP53
ubiquitin-protein transferase activity (GO:0004842)	3.73	2	BRCA1, BARD1
protein phosphatase 2A binding (GO:0051721)	6.41	2	TP53, AKT1
nuclease activity (GO:0004518)	4.33	2	RAD51, XRCC3
four-way junction DNA binding (GO:0000400)	7.03	2	RAD51, XRCC3
phosphatidylinositol kinase activity (GO:0052742)	5.81	2	ATM, PIK3CA
endonuclease activity (GO:0004519)	4.78	2	RAD51, XRCC3
recombinase activity (GO:0000150)	7.66	2	RAD51, XRCC3
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228)	3.98	2	ESR1, TP53
purine NTP-dependent helicase activity (GO:0070035)	5.12	2	NBN, BRIP1
ubiquitin binding (GO:0043130)	5.09	2	FAM175A, TSG101
transcription regulatory region sequence-specific DNA binding (GO:0000976)	3.24	2	ESR1, TP53
RNA binding (GO:0003723)	2.36	2	BRCA1, BARD1
protein heterodimerization activity (GO:0046982)	3.64	2	BARD1, TP53

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
protein methyltransferase activity (GO:0008276)	NEW	5.33	0.036	BRCA1, KRAS, TP53, ESR1
nucleic acid binding transcription factor activity (GO:0001071)	-	2.65	0.001	PHB, ATM, KRAS, BRCA2, ESR1, CASP8, BARD1, TP53, CDH1, RAD51, AKT1, NBN, BRCA1, CHEK2, TSG101
intramolecular oxidoreductase activity (GO:0016860)	NEW	5.75	0.018	PHB, KRAS, AKT1, ESR1
transcription corepressor activity (GO:0003714)	NEW	4.33	0.0	PHB, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
transcription coactivator activity (GO:0003713)	-	4.04	0.001	ATM, ESR1, CASP8, BARD1, TP53, CDH1, AKT1, BRCA1, CHEK2
transcription cofactor activity (GO:0003712)	-	3.44	0.0	ATM, PHB, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
nucleotide binding (GO:0000166)	-	1.96	0.044	ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, PHB, CDH1, RB1CC1, PIK3CA, ESR1, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
transferase activity (GO:0016740)	-	1.95	0.013	PHB, ATM, KRAS, BRCA2, AKT1, CASP8, PPM1D, BARD1, TP53, CDH1, RB1CC1, RAD51, ESR1, PIK3CA, NBN, BRCA1, CHEK2, TSG101
protein binding transcription factor activity (GO:0000988)	-	3.35	0.0	PHB, ATM, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
regulatory region nucleic acid binding (GO:0001067)	-	3.03	0.009	PHB, ATM, AKT1, CASP8, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
helicase activity (GO:0004386)	-	4.69	0.004	ATM, TP53, CHEK2, BRIP1, RAD54L, RAD51
protein kinase binding (GO:0019901)	-	3.44	0.006	ATM, ESR1, BARD1, PIK3CA, RB1CC1, TP53, AKT1, BRCA1, CHEK2, RAD51
kinase binding (GO:0019900)	-	3.32	0.002	ATM, KRAS, AKT1, BARD1, PIK3CA, RB1CC1, TP53, ESR1, BRCA1, CHEK2, RAD51
protein domain specific binding (GO:0019904)	-	3.32	0.006	ATM, KRAS, AKT1, CASP8, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
binding, bridging (GO:0060090)	NEW	4.57	0.002	KRAS, ESR1, TP53, RB1CC1, PIK3CA, AKT1, BRCA1
transcription regulatory region DNA binding (GO:0044212)	-	3.03	0.008	PHB, ATM, AKT1, CASP8, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	-	3.03	0.0	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, TP53, CDH1, PIK3CA, ESR1, RAD54L, BRIP1, CHEK2, RAD51
carbohydrate derivative binding (GO:0097367)	-	2.03	0.013	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, RAD51, ESR1, PIK3CA, NBN, CHEK2, RAD54L, BRIP1, BRCA1, HMMR
hydrolase activity, acting on acid anhydrides (GO:0016817)	-	3.03	0.0	ATM, PHB, XRCC3, KRAS, BRCA2, AKT1, TP53, CDH1, PIK3CA, ESR1, RAD54L, BRIP1, CHEK2, RAD51
sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0000981)	-	3.29	0.002	PHB, ATM, NBN, AKT1, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
phospholipase activity (GO:0004620)	NEW	5.16	0.008	ATM, TP53, CASP8, AKT1, CDH1
lipase activity (GO:0016298)	NEW	4.96	0.015	ATM, TP53, CASP8, AKT1, CDH1
cytokine receptor binding (GO:0005126)	NEW	4.14	0.002	ATM, KRAS, ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1
cytokine activity (GO:0005125)	NEW	4.34	0.012	ATM, ESR1, CASP8, TP53, CDH1, PIK3CA, AKT1
RNA polymerase II regulatory region DNA binding (GO:0001012)	NEW	3.36	0.014	ATM, AKT1, CASP8, TP53, ESR1, BRCA1, CHEK2, TSG101
enhancer sequence-specific DNA binding (GO:0001158)	NEW	5.36	0.003	TP53, BRCA1, ESR1, CHEK2, AKT1
steroid hormone receptor binding (GO:0035258)	NEW	5.32	0.044	BRCA1, ESR1, TP53, AKT1
ATPase activity (GO:0016887)	-	3.65	0.01	PHB, ATM, BRCA2, XRCC3, TP53, ESR1, BRIP1, RAD51
DNA binding (GO:0003677)	-	1.92	0.003	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, PALB2, BARD1, TP53, CDH1, RAD51, ESR1, NBN, CHEK2, BRCA1, BRIP1, RAD54L, TSG101
nucleoside phosphate binding (GO:1901265)	-	1.96	0.044	ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, PHB, CDH1, RB1CC1, PIK3CA, ESR1, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
ATPase activity, coupled (GO:0042623)	-	3.97	0.007	PHB, ATM, XRCC3, TP53, ESR1, BRIP1, RAD51
transcription factor binding transcription factor activity (GO:0000989)	-	3.36	0.0	ATM, PHB, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
ribonucleoside binding (GO:0032549)	-	2.22	0.017	ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, PHB, CDH1, PIK3CA, ESR1, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
purine nucleotide binding (GO:0017076)	-	2.19	0.022	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, NBN, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
oxidoreductase activity (GO:0016491)	NEW	3.12	0.024	ATM, ESR1, BARD1, TP53, CDH1, RB1CC1, NQO2, AKT1, BRCA1, CHEK2, HMMR
histone deacetylase binding (GO:0042826)	NEW	5.08	0.049	PHB, ATM, ESR1, TP53
ATP binding (GO:0005524)	-	2.43	0.002	ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, PHB, CDH1, PIK3CA, ESR1, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
GTP binding (GO:0005525)	NEW	3.78	0.045	ATM, KRAS, ESR1, CDH1, PIK3CA, AKT1, CHEK2, RAD51
tumor necrosis factor receptor superfamily binding (GO:0032813)	NEW	5.89	0.004	ATM, CASP8, TP53, AKT1
protein kinase regulator activity (GO:0019887)	NEW	4.6	0.006	ATM, ESR1, TP53, PIK3CA, AKT1, BRCA1
1-phosphatidylinositol-3-kinase activity (GO:0016303)	-	5.98	0.019	ATM, PIK3CA
kinase activity (GO:0016301)	-	2.93	0.02	PHB, ATM, KRAS, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
hydrolase activity, acting on ester bonds (GO:0016788)	-	3.1	0.001	ATM, ESR1, CASP8, PPM1D, BARD1, TP53, CDH1, PIK3CA, AKT1, CHEK2, BRCA1, RAD54L, RAD51
ubiquitin-protein transferase activity (GO:0004842)	-	3.73	0.007	ESR1, BARD1, CDH1, TP53, AKT1, BRCA1, CHEK2
RNA polymerase II transcription factor binding (GO:0001085)	NEW	5.08	0.012	TP53, BRCA1, ESR1, CHEK2, CDH1
DNA-dependent ATPase activity (GO:0008094)	-	5.31	0.0	ATM, RAD51, BRIP1, TP53, XRCC3
protein binding, bridging (GO:0030674)	NEW	4.68	0.014	ESR1, KRAS, RB1CC1, TP53, AKT1, BRCA1
phosphatidylinositol kinase activity (GO:0052742)	-	5.81	0.044	ATM, PIK3CA
transferase activity, transferring phosphorus-containing groups (GO:0016772)	-	2.77	0.019	PHB, ATM, KRAS, NBN, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
glycosaminoglycan binding (GO:0005539)	NEW	4.42	0.0	ATM, AKT1, CASP8, TP53, RB1CC1, CDH1, ESR1, BRCA1, CHEK2, HMMR
guanyl nucleotide binding (GO:0019001)	NEW	3.73	0.01	ATM, KRAS, ESR1, TP53, CDH1, PIK3CA, AKT1, CHEK2, RAD51
transcription regulatory region sequence-specific DNA binding (GO:0000976)	-	3.24	0.035	ATM, AKT1, CASP8, TP53, ESR1, BRCA1, CHEK2, TSG101
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)	NEW	3.37	0.013	ATM, AKT1, CASP8, TP53, ESR1, BRCA1, CHEK2, TSG101
regulatory region DNA binding (GO:0000975)	-	3.03	0.009	PHB, ATM, AKT1, CASP8, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
purine ribonucleotide binding (GO:0032555)	-	2.2	0.019	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, NBN, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
gamma-tubulin binding (GO:0043015)	NEW	6.56	0.021	BARD1, BRCA1, BRCA2
protein dimerization activity (GO:0046983)	-	2.72	0.0	ATM, PHB, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, RAD51, ESR1, PIK3CA, BRCA1, BRIP1, CHEK2, TSG101
protein heterodimerization activity (GO:0046982)	-	3.64	0.002	ATM, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, ESR1, BRCA1, CHEK2
purine ribonucleoside binding (GO:0032550)	-	2.22	0.017	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, NBN, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
ribonucleotide binding (GO:0032553)	-	2.19	0.021	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, NBN, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
protein C-terminus binding (GO:0008022)	-	4.5	0.001	ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1, CHEK2, RAD51
phosphatase activity (GO:0016791)	NEW	4.11	0.002	ATM, CASP8, PPM1D, TP53, CDH1, AKT1, CHEK2, RAD51
calcium-dependent protein binding (GO:0048306)	NEW	5.68	0.001	TP53, KRAS, AKT1, TSG101, PIK3CA
enzyme binding (GO:0019899)	-	2.27	0.0	ATM, NBN, SLC22A18, KRAS, BRCA2, AKT1, CASP8, PPM1D, BARD1, TSG101, TP53, PHB, CDH1, RB1CC1, RAD51, PIK3CA, ESR1, BRCA1, CHEK2, HMMR
phosphoric ester hydrolase activity (GO:0042578)	NEW	3.82	0.031	ATM, CASP8, PPM1D, TP53, CDH1, AKT1, CHEK2, RAD51
enzyme inhibitor activity (GO:0004857)	NEW	3.78	0.013	ATM, ESR1, CASP8, BARD1, PIK3CA, CDH1, TP53, AKT1, BRCA1
kinase regulator activity (GO:0019207)	NEW	4.5	0.017	ATM, ESR1, TP53, PIK3CA, AKT1, BRCA1
anion binding (GO:0043168)	NEW	4.17	0.011	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, RAD51, ESR1, PIK3CA, NBN, CHEK2, RAD54L, BRIP1, BRCA1, TSG101
sequence-specific DNA binding (GO:0043565)	-	2.79	0.0	ATM, NBN, KRAS, BRCA2, AKT1, CASP8, RAD51, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
structure-specific DNA binding (GO:0043566)	-	4.98	0.0	ATM, XRCC3, BRCA2, ESR1, TP53, CDH1, AKT1, CHEK2, RAD51
receptor regulator activity (GO:0030545)	NEW	5.91	0.029	TP53, ESR1, AKT1, CDH1
guanyl ribonucleotide binding (GO:0032561)	NEW	3.73	0.01	ATM, KRAS, ESR1, TP53, CDH1, PIK3CA, AKT1, CHEK2, RAD51
protease binding (GO:0002020)	-	5.08	0.008	PHB, CASP8, BRCA2, TP53, AKT1
protein complex binding (GO:0032403)	-	3.09	0.008	ATM, KRAS, AKT1, CASP8, RAD51, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, CHEK2, TSG101
double-stranded DNA binding (GO:0003690)	-	3.09	0.0	ATM, XRCC3, ESR1, CDH1, TP53, AKT1, RAD51
protein homodimerization activity (GO:0042803)	-	3.16	0.0	ATM, PHB, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, RAD51, ESR1, PIK3CA, BRCA1, BRIP1, CHEK2, TSG101
transporter activity (GO:0005215)	NEW	2.57	0.008	ATM, PHB, SLC22A18, KRAS, AKT1, CASP8, BARD1, RAD51, TP53, CDH1, RB1CC1, PIK3CA, ESR1, TSG101
transcription factor binding (GO:0008134)	-	3.46	0.0	PHB, ATM, XRCC3, NBN, AKT1, CASP8, TP53, CDH1, ESR1, BRCA1, CHEK2, TSG101
protein kinase inhibitor activity (GO:0004860)	NEW	5.28	0.027	ATM, BRCA1, ESR1, AKT1
cofactor binding (GO:0048037)	NEW	4.16	0.042	PHB, ESR1, CDH1, RB1CC1, TP53, AKT1, CHEK2
enhancer binding (GO:0035326)	NEW	5.21	0.008	TP53, BRCA1, ESR1, CHEK2, AKT1
cysteine-type endopeptidase inhibitor activity (GO:0004869)	NEW	5.71	0.001	TP53, CASP8, ESR1, AKT1, CDH1
ubiquitin protein ligase binding (GO:0031625)	-	4.17	0.0	ATM, SLC22A18, CASP8, TP53, AKT1, BRCA1, CHEK2, TSG101
protein N-terminus binding (GO:0047485)	-	5.11	0.0	ATM, NBN, BARD1, TP53, AKT1, CHEK2, TSG101
adenyl nucleotide binding (GO:0030554)	-	2.4	0.002	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, NBN, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001228)	-	3.98	0.017	NBN, ESR1, TP53, AKT1, BRCA1, CHEK2, TSG101
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	-	3.08	0.006	PHB, ATM, KRAS, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, BRCA1, CHEK2, RAD51
RNA binding (GO:0003723)	-	2.36	0.003	PHB, NBN, KRAS, AKT1, CASP8, PPM1D, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, BRIP1, RAD51
protein binding (GO:0005515)	-	0.46	0.0	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, SLC22A18, BARD1, CDH1, AKT1, BRIP1, BRCA2, RAD51, ESR1, CHEK2, TSG101
receptor binding (GO:0005102)	-	2.43	0.003	ATM, PHB, XRCC3, KRAS, AKT1, CASP8, BARD1, TP53, CDH1, RB1CC1, PIK3CA, ESR1, BRCA1, HMMR, CHEK2, TSG101
p53 binding (GO:0002039)	NEW	5.53	0.009	ESR1, RAD51, TP53, CDH1
damaged DNA binding (GO:0003684)	-	5.58	0.0	ATM, NBN, BRCA1, RAD51, TP53
small conjugating protein ligase binding (GO:0044389)	-	4.15	0.0	ATM, SLC22A18, CASP8, TP53, AKT1, BRCA1, CHEK2, TSG101
phosphatidylinositol 3-kinase activity (GO:0035004)	-	5.49	0.019	ATM, PIK3CA
purine nucleoside binding (GO:0001883)	-	2.22	0.017	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, CDH1, PIK3CA, ESR1, NBN, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
nucleoside binding (GO:0001882)	-	2.21	0.018	ATM, NBN, XRCC3, KRAS, BRCA2, AKT1, CASP8, TP53, PHB, CDH1, PIK3CA, ESR1, CHEK2, RAD54L, BRIP1, BRCA1, RAD51
oxidoreductase activity, acting on CH or CH2 groups (GO:0016725)	NEW	7.44	0.004	BARD1, ESR1, AKT1
pyrophosphatase activity (GO:0016462)	-	3.04	0.0	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, TP53, CDH1, PIK3CA, ESR1, RAD54L, BRIP1, CHEK2, RAD51
structural molecule activity (GO:0005198)	NEW	3.1	0.006	KRAS, ESR1, CASP8, TP53, CDH1, RB1CC1, RAD51, AKT1, BRCA1, BRIP1, TSG101
protein serine/threonine kinase activity (GO:0004674)	-	3.64	0.028	PHB, ATM, ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1, CHEK2
protein kinase activity (GO:0004672)	-	3.27	0.01	ATM, PHB, KRAS, ESR1, TP53, CDH1, PIK3CA, AKT1, BRCA1, CHEK2, RAD51
kinase inhibitor activity (GO:0019210)	NEW	5.25	0.039	ATM, BRCA1, ESR1, AKT1
nitric-oxide synthase regulator activity (GO:0030235)	-	7.79	0.006	ESR1, AKT1
nucleoside-triphosphatase activity (GO:0017111)	-	3.09	0.0	PHB, ATM, XRCC3, KRAS, BRCA2, AKT1, TP53, CDH1, PIK3CA, ESR1, RAD54L, BRIP1, CHEK2, RAD51
ligase activity (GO:0016874)	-	3.72	0.013	ATM, BARD1, CDH1, TP53, ESR1, BRCA1, CHEK2, RAD51
sequence-specific DNA binding transcription factor activity (GO:0003700)	-	2.65	0.001	PHB, ATM, KRAS, BRCA2, AKT1, CASP8, BARD1, TP53, CDH1, RAD51, ESR1, NBN, BRCA1, CHEK2, TSG101

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	24	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1, BRIP1, HMMR, BRCA2, RAD51, ESR1, CHEK2, TSG101
metabolic process (GO:0008152)	0.58	24	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, AKT1, BRIP1, HMMR, BRCA2, NQO2, RAD51, ESR1, CHEK2, TSG101
organic substance metabolic process (GO:0071704)	0.63	23	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, AKT1, BRIP1, HMMR, BRCA2, TSG101, ESR1, CHEK2, RAD51
macromolecule metabolic process (GO:0043170)	0.83	23	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, AKT1, BRIP1, HMMR, BRCA2, TSG101, ESR1, CHEK2, RAD51
primary metabolic process (GO:0044238)	0.69	22	ATM, PALB2, TP53, FAM175A, RB1CC1, KRAS, XRCC3, RAD54L, PHB, CASP8, PPM1D, PIK3CA, BRCA1, NBN, BARD1, AKT1, BRIP1, BRCA2, TSG101, ESR1, CHEK2, RAD51
response to stimulus (GO:0050896)	1.22	22	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, RAD54L, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1, BRIP1, BRCA2, ESR1, CHEK2, RAD51
biological regulation (GO:0065007)	0.39	22	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1, BRIP1, BRCA2, TSG101, ESR1, CHEK2, RAD51
regulation of biological process (GO:0050789)	0.45	22	ATM, PALB2, TP53, FAM175A, RB1CC1, PIK3CA, XRCC3, PHB, CASP8, PPM1D, KRAS, BRCA1, NBN, BARD1, CDH1, AKT1,