Disease table of JUVENILE MYELOMONOCYTIC LEUKEMIA OMIM ID: 607785

Gene-disease associations table

GeneAssociated with JUVENILE MYELOMONOCYTIC LEUKEMIA inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
SETBP1HUMSAVARHGNC link18q12.36601626, 614286, 608232, 269150, PS156200, 607785
PTPN11ClinVar, OMIM, HUMSAVARHGNC link12q24.134PS163950, 607785, 156250, PS151100
NRASClinVar, HUMSAVARHGNC link1p13.28137550, PS163950, 249400, 163200, 607785, 114500, 614470, 162900
CBLClinVarHGNC link11q23.32607785, 613563
MLLT11OMIMHGNC link1q21.31607785
ARHGAP26ClinVar, OMIM, HUMSAVARHGNC link5q31.31607785
NF1ClinVar, OMIMHGNC link17q11.25607785, 193520, 162200, 162210, 601321
KRASClinVarHGNC link12p12.114601626, 600268, 137215, 109800, PS163950, 211980, 114480, PS115150, 613659, 163200, 607785, 614470, 162900, 260350

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
122KRAS, PTPN11
12NRAS, MLLT11
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
SETBP1YES3PTGS2, PTGER2, PPP2R40
NF1YES12PPP2R2D, SFTPB, GNRH1, TP53, DDB1, AFP, HSD11B2, SP3, PLAT, FOS, MYC, DDB20
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
NRASYES1AR0
NF1YES12SP1, TBPL1, IRF8, GFI1, TBP, YY1, TWIST2, TWIST1, CREB1, CTCF, RUNX1, FOXA10
KRASYES1MYC0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
SETBP1KRASNo1APP
PTPN11NRASNo1ELAVL1
PTPN11CBLYes32PTPN11, FLT1, PIK3R2, EGFR, FYN, CRKL, CD33, CRK, STAT5A, PTK2, EPHA2, ERBB2, EPOR, CTNNB1, SOS1, MAPK14, KIT, INPP5D, CBL, CBLB, IL6ST, GRB2, STAT3, FCGR2A, IGF1R, IRS1, PIK3R1, ERBB4, NTRK1, FRS2, PTK2B, BCAR1
PTPN11ARHGAP26No1PTK2
PTPN11NF1No3CD274, SLAMF1, CAV1
PTPN11KRASNo2PIK3R2, ELAVL1
NRASCBLNo2EEF1A1, CD2AP
NRASKRASNo6RGL2, RAP1GDS1, ELAVL1, PIK3CG, RAF1, EEF1A1
CBLARHGAP26No3CDC42, PTK2, PTEN
CBLNF1No2HRAS, YWHAB
CBLKRASNo5EEF1A1, PIK3R2, CALM1, SORBS3, PIK3CA

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
NF1KRASYes1KRAS

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
PTPN11CBLYesbinding91MS4A2, RET, IFNG, PXN, SOS1, RAP1A, PDGFB, VEGFA, PDGFRB, PTK2, STAT5A, CSF2RA, MAPK14, UBA52, PIK3CB, IL2, PIK3R1, INS, JAK1, FLT3, FRS2, TYK2, EGFR, FLT1, JAK2, UBB, GHR, IL2RB, SOCS3, PRLR, HGF, GRB2, PIK3R3, VAV2, IGF1R, SPRY2, BCAR1, UBC, PLCG1, GNG2, IFNGR2, IL3RA, SYK, RAP1B, FYN, INSR, PIK3R5, CSK, MET, SOCS1, ERBB3, LCP2, IFNAR1, KIT, LCK, HRAS, VAV1, CSF2RB, PPP2R1A, FCER1G, YES1, KDR, PIK3CD, EPOR, FCER1A, HCK, PPP2CA, LYN, PIK3CG, CRKL, RPS27A, IL4, CRK, PIK3CA, EPHA2, ERBB2, PPP2CB, SHC1, GNB1, RAPGEF1, EGF, SRC, IL5RA, IL6ST, IL6R, ITSN1, PTK2B, IRS1, SDC2, LAT, ERBB4
PTPN11MLLT11No-1UBC
PTPN11ARHGAP26No-2UBC, RHOA
PTPN11KRASYesactivation, binding44MAP2K2, EGFR, MAPK1, RET, TP53, SHC1, PIK3CA, PIK3CG, TEK, VEGFA, GRB2, ANGPT1, MAPK11, MAP2K1, PTK2, EPHA2, ERBB2, ERBB3, SOS1, MAPK12, MAPK7, KIT, HRAS, MAPK13, FRS2, UBC, PIK3CB, PPP2CA, AKT1, SRC, FYN, MAPK14, YES1, ITSN1, MAPK3, JUN, MTOR, SPRY2, IRS2, EGF, IRS1, PIK3CD, MLLT4, ERBB4
CBLMLLT11No-1UBC
CBLARHGAP26No-3UBC, RHOQ, CDC42
CBLKRASNo-32PTPN11, EGFR, RET, PPP2CA, SHC1, PIK3CA, PIK3CG, VEGFA, YWHAB, ITSN1, PTK2, EPHA2, ERBB2, ERBB3, SOS1, MAPK14, KIT, HRAS, UBC, PIK3CB, GRB2, ABL1, SRC, FYN, PIK3CD, YES1, NOTCH1, IRS1, SPRY2, EGF, FRS2, ERBB4
MLLT11ARHGAP26No-1UBC
MLLT11KRASNo-1UBC
ARHGAP26KRASNo-2UBC, TSG101

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
PTPN11CBLNo-3PLCG1, GRB2, PIK3R1
NRASKRASYesRAF1-RAS complex, EGF induced2HRAS, RAF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
KRASNRASmaybe, indirectThey are members of the same protein family.
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Proteoglycans in cancerhsa052055.024PTPN11, KRAS, CBL, NRAS
Ras signaling pathwayhsa040144.94PTPN11, KRAS, NF1, NRAS
Chronic myeloid leukemiahsa052206.484PTPN11, KRAS, CBL, NRAS
Natural killer cell mediated cytotoxicityhsa046505.533PTPN11, KRAS, NRAS
Renal cell carcinomahsa052116.63PTPN11, KRAS, NRAS
Pathways in cancerhsa052003.983CBL, KRAS, NRAS
T cell receptor signaling pathwayhsa046606.013CBL, KRAS, NRAS
Insulin signaling pathwayhsa049105.553CBL, KRAS, NRAS
Neurotrophin signaling pathwayhsa047225.783PTPN11, KRAS, NRAS
ErbB signaling pathwayhsa040126.153CBL, KRAS, NRAS
MAPK signaling pathwayhsa040104.633NF1, KRAS, NRAS
Signaling pathways regulating pluripotency of stem cellshsa045505.62KRAS, NRAS
Bladder cancerhsa052197.382KRAS, NRAS
Endometrial cancerhsa052136.812KRAS, NRAS
Thyroid cancerhsa052167.482KRAS, NRAS
Melanomahsa052186.562KRAS, NRAS
Gliomahsa052146.662KRAS, NRAS
Jak-STAT signaling pathwayhsa046305.442PTPN11, CBL
Tight junctionhsa045305.532KRAS, NRAS
Long-term potentiationhsa047206.642KRAS, NRAS
Cholinergic synapsehsa047255.882KRAS, NRAS
Choline metabolism in cancerhsa052316.092KRAS, NRAS
FoxO signaling pathwayhsa040685.632KRAS, NRAS
Serotonergic synapsehsa047265.842KRAS, NRAS
Chemokine signaling pathwayhsa040625.192KRAS, NRAS
Oxytocin signaling pathwayhsa049215.42KRAS, NRAS
HTLV-I infectionhsa051664.592KRAS, NRAS
Regulation of actin cytoskeletonhsa048104.92KRAS, NRAS
Hepatitis Chsa051605.682KRAS, NRAS
Hepatitis Bhsa051615.522KRAS, NRAS
Gap junctionhsa045406.242KRAS, NRAS
VEGF signaling pathwayhsa043706.772KRAS, NRAS
MicroRNAs in cancerhsa052065.382KRAS, NRAS
Viral carcinogenesishsa052035.082KRAS, NRAS
GnRH signaling pathwayhsa049126.182KRAS, NRAS
B cell receptor signaling pathwayhsa046626.522KRAS, NRAS
Non-small cell lung cancerhsa052236.882KRAS, NRAS
Prolactin signaling pathwayhsa049176.62KRAS, NRAS
Acute myeloid leukemiahsa052216.742KRAS, NRAS
Estrogen signaling pathwayhsa049156.112KRAS, NRAS
Thyroid hormone signaling pathwayhsa049195.822KRAS, NRAS
Long-term depressionhsa047306.742KRAS, NRAS
PI3K-Akt signaling pathwayhsa041514.212KRAS, NRAS
Prostate cancerhsa052156.112KRAS, NRAS
Rap1 signaling pathwayhsa040154.972KRAS, NRAS
Melanogenesishsa049165.972KRAS, NRAS
Alcoholismhsa050345.592KRAS, NRAS
Axon guidancehsa043605.632KRAS, NRAS
Central carbon metabolism in cancerhsa052306.72KRAS, NRAS
Fc epsilon RI signaling pathwayhsa046646.62KRAS, NRAS

NET-GE enrichment

Term New enriched termICP valueGenes
Cancers: Specific typesNEW4.10.005PTPN11, KRAS, CBL, NRAS
Gap junction (hsa04540) -6.240.038CBL, KRAS, NRAS
Proteoglycans in cancer (hsa05205) -5.020.025PTPN11, KRAS, CBL, NRAS
Natural killer cell mediated cytotoxicity (hsa04650) -5.530.003PTPN11, KRAS, CBL, NRAS
Renal cell carcinoma (hsa05211) -6.60.001PTPN11, KRAS, NRAS
Thyroid cancer (hsa05216) -7.480.025KRAS, NRAS
Insulin signaling pathway (hsa04910) -5.550.008CBL, KRAS, NRAS
Prostate cancer (hsa05215) -6.110.026CBL, KRAS, NRAS
T cell receptor signaling pathway (hsa04660) -6.010.003PTPN11, KRAS, CBL, NRAS
Ras signaling pathway (hsa04014) -4.90.001PTPN11, KRAS, NF1, NRAS, CBL
Neurotrophin signaling pathway (hsa04722) -5.780.005PTPN11, KRAS, NRAS
Rap1 signaling pathway (hsa04015) -4.970.047PTPN11, KRAS, CBL, NRAS
Endocrine systemNEW3.260.045PTPN11, KRAS, CBL, NRAS
Chronic myeloid leukemia (hsa05220) -6.480.0PTPN11, KRAS, CBL, NRAS
Axon guidance (hsa04360) -5.630.004PTPN11, KRAS, NF1, NRAS
DevelopmentNEW4.580.006PTPN11, KRAS, NF1, NRAS, CBL
Bladder cancer (hsa05219) -7.380.029KRAS, NRAS
ErbB signaling pathway (hsa04012) -6.150.002CBL, KRAS, NRAS
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signal TransductionR-HSA-1625821.786PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS
Signaling by FGFRR-HSA-1902364.675PTPN11, KRAS, NF1, NRAS, CBL
Signaling by InterleukinsR-HSA-4491474.715PTPN11, KRAS, NF1, NRAS, CBL
Signaling by FGFR1R-HSA-56547364.695PTPN11, KRAS, NF1, NRAS, CBL
Signaling by FGFR2R-HSA-56547384.685PTPN11, KRAS, NF1, NRAS, CBL
Immune SystemR-HSA-1682562.375PTPN11, KRAS, NF1, NRAS, CBL
Signaling by SCF-KITR-HSA-14335574.735PTPN11, KRAS, NF1, NRAS, CBL
Signaling by FGFR4R-HSA-56547434.695PTPN11, KRAS, NF1, NRAS, CBL
Cytokine Signaling in Immune systemR-HSA-12802153.745PTPN11, KRAS, NF1, NRAS, CBL
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.995PTPN11, KRAS, NF1, NRAS, CBL
Signaling by EGFRR-HSA-1779294.595PTPN11, KRAS, NF1, CBL, NRAS
Signaling by FGFR3R-HSA-56547414.695PTPN11, KRAS, NF1, CBL, NRAS
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.854PTPN11, KRAS, NF1, NRAS
Signaling by LeptinR-HSA-25865525.14PTPN11, KRAS, NF1, NRAS
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.624PTPN11, KRAS, CBL, NRAS
IGF1R signaling cascadeR-HSA-24289244.854PTPN11, KRAS, NF1, NRAS
Downstream signal transductionR-HSA-1867634.654PTPN11, KRAS, NF1, NRAS
IRS-related events triggered by IGF1RR-HSA-24289284.854PTPN11, KRAS, NF1, NRAS
Signaling by ERBB4R-HSA-12363944.74PTPN11, KRAS, NF1, NRAS
Signaling by Insulin receptorR-HSA-747524.734PTPN11, KRAS, NF1, NRAS
Adaptive Immune SystemR-HSA-12802183.194PTPN11, KRAS, CBL, NRAS
DiseaseR-HSA-16436853.334PTPN11, KRAS, CBL, NRAS
Insulin receptor signalling cascadeR-HSA-747514.854PTPN11, KRAS, NF1, NRAS
Downstream signaling of activated FGFR1R-HSA-56546874.714PTPN11, KRAS, NF1, NRAS
MAPK family signaling cascadesR-HSA-56830574.894PTPN11, KRAS, NF1, NRAS
Signalling by NGFR-HSA-1665204.234PTPN11, KRAS, NF1, NRAS
MAPK1/MAPK3 signalingR-HSA-56849965.114PTPN11, KRAS, NF1, NRAS
IRS-mediated signallingR-HSA-1123994.874PTPN11, KRAS, NF1, NRAS
FRS-mediated FGFR2 signalingR-HSA-56547005.144PTPN11, KRAS, NF1, NRAS
DAP12 interactionsR-HSA-21721274.564PTPN11, KRAS, NF1, NRAS
FRS-mediated FGFR3 signalingR-HSA-56547065.144PTPN11, KRAS, NF1, NRAS
Developmental BiologyR-HSA-12667383.484PTPN11, KRAS, NF1, NRAS
Downstream signaling of activated FGFR3R-HSA-56547084.714PTPN11, KRAS, NF1, NRAS
Diseases of signal transductionR-HSA-56632024.894PTPN11, KRAS, CBL, NRAS
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.034PTPN11, KRAS, NF1, NRAS
Innate Immune SystemR-HSA-1682493.174PTPN11, KRAS, NF1, NRAS
Signaling by PDGFR-HSA-1867974.534PTPN11, KRAS, NF1, NRAS
DAP12 signalingR-HSA-24244914.644PTPN11, KRAS, NF1, NRAS
Downstream signaling of activated FGFR2R-HSA-56546964.714PTPN11, KRAS, NF1, NRAS
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.514PTPN11, KRAS, NF1, NRAS
FRS-mediated FGFR1 signalingR-HSA-56546935.144PTPN11, KRAS, NF1, NRAS
FRS-mediated FGFR4 signalingR-HSA-56547125.144PTPN11, KRAS, NF1, NRAS
Downstream signaling of activated FGFR4R-HSA-56547164.714PTPN11, KRAS, NF1, NRAS
Signaling by ERBB2R-HSA-12279864.664PTPN11, KRAS, NF1, NRAS
Axon guidanceR-HSA-4224753.934PTPN11, KRAS, NF1, NRAS
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.263NF1, KRAS, NRAS
GRB2 events in ERBB2 signalingR-HSA-19636405.153NF1, KRAS, NRAS
Frs2-mediated activationR-HSA-1709685.123NF1, KRAS, NRAS
Cell surface interactions at the vascular wallR-HSA-2027336.323PTPN11, KRAS, NRAS
Signaling by EGFRvIII in CancerR-HSA-56378129.083CBL, KRAS, NRAS
RAF/MAP kinase cascadeR-HSA-56730015.153NF1, KRAS, NRAS
Signaling by VEGFR-HSA-1941384.663NF1, KRAS, NRAS
Signalling to p38 via RIT and RINR-HSA-1877065.123NF1, KRAS, NRAS
FCERI mediated MAPK activationR-HSA-28717964.323NF1, KRAS, NRAS
Signaling by Ligand-Responsive EGFR Variants in CancerR-HSA-56378158.733CBL, KRAS, NRAS
Constitutive Signaling by EGFRvIIIR-HSA-56378109.083CBL, KRAS, NRAS
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.593PTPN11, KRAS, NRAS
Signaling by EGFR in CancerR-HSA-16437138.733CBL, KRAS, NRAS
VEGFA-VEGFR2 PathwayR-HSA-44200974.73NF1, KRAS, NRAS
Interleukin-2 signalingR-HSA-4519275.053NF1, KRAS, NRAS
Interleukin receptor SHC signalingR-HSA-9125265.093NF1, KRAS, NRAS
Signalling to ERKsR-HSA-1876875.043NF1, KRAS, NRAS
NCAM signaling for neurite out-growthR-HSA-3751654.93NF1, KRAS, NRAS
Signalling to RASR-HSA-1670445.083NF1, KRAS, NRAS
SHC-mediated cascade:FGFR2R-HSA-56546998.283PTPN11, KRAS, NRAS
Constitutive Signaling by Ligand-Responsive EGFR Cancer VariantsR-HSA-12363828.733CBL, KRAS, NRAS
SHC1 events in EGFR signalingR-HSA-1803365.153NF1, KRAS, NRAS
Prolonged ERK activation eventsR-HSA-1698935.113NF1, KRAS, NRAS
Regulation of RAS by GAPsR-HSA-56584426.923NF1, KRAS, NRAS
Signaling by GPCRR-HSA-3727902.683NF1, KRAS, NRAS
GRB2 events in EGFR signalingR-HSA-1798125.153NF1, KRAS, NRAS
SHC1 events in ERBB4 signalingR-HSA-12503475.153NF1, KRAS, NRAS
ARMS-mediated activationR-HSA-1709845.123NF1, KRAS, NRAS
SOS-mediated signallingR-HSA-1124125.153NF1, KRAS, NRAS
Tie2 SignalingR-HSA-2109938.813PTPN11, KRAS, NRAS
SHC1 events in ERBB2 signalingR-HSA-12501965.153NF1, KRAS, NRAS
SHC-mediated cascade:FGFR4R-HSA-56547198.463PTPN11, KRAS, NRAS
VEGFR2 mediated cell proliferationR-HSA-52189215.073NF1, KRAS, NRAS
HemostasisR-HSA-1095823.983PTPN11, KRAS, NRAS
p38MAPK eventsR-HSA-1710079.282KRAS, NRAS
Signaling by FGFR3 in diseaseR-HSA-56553328.522KRAS, NRAS
MAP2K and MAPK activationR-HSA-56741357.662KRAS, NRAS
RAF activationR-HSA-56730008.342KRAS, NRAS
SHC-mediated cascade:FGFR1R-HSA-56546888.592KRAS, NRAS
Negative regulation of FGFR1 signalingR-HSA-56547267.982PTPN11, CBL
Negative regulation of FGFR2 signalingR-HSA-56547277.892PTPN11, CBL
SHC-mediated cascade:FGFR3R-HSA-56547048.812KRAS, NRAS
Activation of RAS in B cellsR-HSA-116909210.662KRAS, NRAS
Signaling by FGFR in diseaseR-HSA-12260997.492KRAS, NRAS
C-type lectin receptors (CLRs)R-HSA-56214816.062KRAS, NRAS
Spry regulation of FGF signalingR-HSA-12955969.182PTPN11, CBL
Negative regulation of MAPK pathwayR-HSA-56752217.662KRAS, NRAS
Signaling by FGFR1 in diseaseR-HSA-56553027.812KRAS, NRAS
SHC-related events triggered by IGF1RR-HSA-24289339.812KRAS, NRAS
Interleukin-6 signalingR-HSA-10596839.522PTPN11, CBL
Negative regulation of FGFR4 signalingR-HSA-56547338.032PTPN11, CBL
Negative regulation of FGFR3 signalingR-HSA-56547328.122PTPN11, CBL
CD209 (DC-SIGN) signalingR-HSA-56215758.592KRAS, NRAS
Signaling by FGFR4 in diseaseR-HSA-56552919.522KRAS, NRAS
EGFR Transactivation by GastrinR-HSA-21793929.812KRAS, NRAS
Signaling by FGFR2 in diseaseR-HSA-56552538.232KRAS, NRAS

NET-GE enrichment

Term New enriched termICP valueGenes
Interleukin-2 signaling (R-HSA-451927) -5.050.0PTPN11, KRAS, NF1, NRAS, CBL
Signaling by the B Cell Receptor (BCR) (R-HSA-983705) -4.620.006PTPN11, KRAS, CBL, NRAS
Signaling by VEGF (R-HSA-194138) -4.660.002PTPN11, KRAS, NF1, NRAS, CBL
FCERI mediated MAPK activation (R-HSA-2871796) -4.320.002PTPN11, KRAS, NF1, NRAS, CBL
IRS-mediated signalling (R-HSA-112399) -4.870.001PTPN11, KRAS, NF1, NRAS, CBL
Signaling by Ligand-Responsive EGFR Variants in Cancer (R-HSA-5637815) -8.730.0CBL, KRAS, NRAS
Constitutive Signaling by EGFRvIII (R-HSA-5637810) -9.080.0CBL, KRAS, NRAS
Signaling by EGFRvIII in Cancer (R-HSA-5637812) -9.080.0CBL, KRAS, NRAS
VEGFA-VEGFR2 Pathway (R-HSA-4420097) -4.70.002PTPN11, KRAS, NF1, CBL, NRAS
Spry regulation of FGF signaling (R-HSA-1295596) -9.180.006PTPN11, CBL
Signaling by FGFR1 in disease (R-HSA-5655302) -7.810.043KRAS, NRAS
Downstream signaling of activated FGFR3 (R-HSA-5654708) -4.710.002PTPN11, KRAS, NF1, NRAS, CBL
DAP12 interactions (R-HSA-2172127) -4.560.007PTPN11, KRAS, NF1, CBL, NRAS
Tie2 Signaling (R-HSA-210993) -8.810.0PTPN11, KRAS, NRAS
Downstream signaling of activated FGFR4 (R-HSA-5654716) -4.710.002PTPN11, KRAS, NF1, NRAS, CBL
Signaling by ERBB2 (R-HSA-1227986) -4.660.002PTPN11, KRAS, NF1, CBL, NRAS
VEGFR2 mediated cell proliferation (R-HSA-5218921) -5.070.0PTPN11, KRAS, NF1, NRAS, CBL
GRB2 events in ERBB2 signaling (R-HSA-1963640) -5.150.0PTPN11, KRAS, NF1, NRAS, CBL
Frs2-mediated activation (R-HSA-170968) -5.120.0PTPN11, KRAS, NF1, NRAS, CBL
Downstream signal transduction (R-HSA-186763) -4.650.003PTPN11, KRAS, NF1, CBL, NRAS
RAF activation (R-HSA-5673000) -8.340.039KRAS, NRAS
RAF/MAP kinase cascade (R-HSA-5673001) -5.150.0PTPN11, KRAS, NF1, CBL, NRAS
Regulation of signaling by CBL (R-HSA-912631) NEW8.520.017PTPN11, CBL
Signalling to p38 via RIT and RIN (R-HSA-187706) -5.120.0PTPN11, KRAS, NF1, CBL, NRAS
FRS-mediated FGFR2 signaling (R-HSA-5654700) -5.140.001PTPN11, KRAS, NF1, CBL, NRAS
FRS-mediated FGFR4 signaling (R-HSA-5654712) -5.140.001PTPN11, KRAS, NF1, CBL, NRAS
FRS-mediated FGFR3 signaling (R-HSA-5654706) -5.140.001PTPN11, KRAS, NF1, NRAS, CBL
SHC-mediated cascade:FGFR3 (R-HSA-5654704) -8.810.015KRAS, NRAS
Activation of RAS in B cells (R-HSA-1169092) -10.660.001KRAS, NRAS
Signaling by EGFR in Cancer (R-HSA-1643713) -8.730.0CBL, KRAS, NRAS
Fc epsilon receptor (FCERI) signaling (R-HSA-2454202) -4.030.029PTPN11, KRAS, NF1, CBL, NRAS
Interleukin receptor SHC signaling (R-HSA-912526) -5.090.0PTPN11, KRAS, NF1, CBL, NRAS
SHC-mediated cascade:FGFR4 (R-HSA-5654719) -8.460.0PTPN11, KRAS, NRAS
SHC-related events triggered by IGF1R (R-HSA-2428933) -9.810.002KRAS, NRAS
NGF signalling via TRKA from the plasma membrane (R-HSA-187037) -4.510.008PTPN11, KRAS, NF1, CBL, NRAS
Prolonged ERK activation events (R-HSA-169893) -5.110.0PTPN11, KRAS, NF1, NRAS, CBL
Signaling by FGFR2 (R-HSA-5654738) -4.680.002PTPN11, KRAS, NF1, CBL, NRAS
GRB2 events in EGFR signaling (R-HSA-179812) -5.150.0PTPN11, KRAS, NF1, CBL, NRAS
Signaling by FGFR1 (R-HSA-5654736) -4.690.0PTPN11, KRAS, NF1, NRAS, CBL
Negative regulation of FGFR4 signaling (R-HSA-5654733) -8.030.032PTPN11, CBL
Negative regulation of FGFR3 signaling (R-HSA-5654732) -8.120.028PTPN11, CBL
EGFR Transactivation by Gastrin (R-HSA-2179392) -9.810.002KRAS, NRAS
Axon guidance (R-HSA-422475) -3.930.037PTPN11, KRAS, NF1, CBL, NRAS
Signaling by FGFR2 in disease (R-HSA-5655253) -8.230.034KRAS, NRAS
Gastrin-CREB signalling pathway via PKC and MAPK (R-HSA-881907) -4.260.009PTPN11, KRAS, NF1, NRAS, CBL
Signaling by FGFR3 in disease (R-HSA-5655332) -8.520.016KRAS, NRAS
Signaling by Leptin (R-HSA-2586552) -5.10.002PTPN11, KRAS, NF1, NRAS, CBL
IGF1R signaling cascade (R-HSA-2428924) -4.850.001PTPN11, KRAS, NF1, CBL, NRAS
IRS-related events triggered by IGF1R (R-HSA-2428928) -4.850.001PTPN11, KRAS, NF1, CBL, NRAS
Signaling by Insulin receptor (R-HSA-74752) -4.730.002PTPN11, KRAS, NF1, CBL, NRAS
Insulin receptor signalling cascade (R-HSA-74751) -4.850.001PTPN11, KRAS, NF1, NRAS, CBL
Downstream signaling of activated FGFR1 (R-HSA-5654687) -4.710.002PTPN11, KRAS, NF1, NRAS, CBL
SHC-mediated cascade:FGFR1 (R-HSA-5654688) -8.590.025KRAS, NRAS
Negative regulation of FGFR1 signaling (R-HSA-5654726) -7.980.034PTPN11, CBL
Negative regulation of FGFR2 signaling (R-HSA-5654727) -7.890.039PTPN11, CBL
Downstream signaling events of B Cell Receptor (BCR) (R-HSA-1168372) -5.590.005PTPN11, KRAS, CBL, NRAS
Diseases of signal transduction (R-HSA-5663202) -4.890.003PTPN11, KRAS, CBL, NRAS
Signalling to RAS (R-HSA-167044) -5.080.0PTPN11, KRAS, NF1, CBL, NRAS
SHC-mediated cascade:FGFR2 (R-HSA-5654699) -8.280.0PTPN11, KRAS, NRAS
Downstream signaling of activated FGFR2 (R-HSA-5654696) -4.710.002PTPN11, KRAS, NF1, CBL, NRAS
SHC1 events in EGFR signaling (R-HSA-180336) -5.150.0PTPN11, KRAS, NF1, NRAS, CBL
FRS-mediated FGFR1 signaling (R-HSA-5654693) -5.140.001PTPN11, KRAS, NF1, CBL, NRAS
Interleukin-6 signaling (R-HSA-1059683) -9.520.004PTPN11, CBL
SHC1 events in ERBB2 signaling (R-HSA-1250196) -5.150.0PTPN11, KRAS, NF1, NRAS, CBL
Signaling by EGFR (R-HSA-177929) -4.590.003PTPN11, KRAS, NF1, CBL, NRAS
ARMS-mediated activation (R-HSA-170984) -5.120.0PTPN11, KRAS, NF1, CBL, NRAS
CD209 (DC-SIGN) signaling (R-HSA-5621575) -8.590.032KRAS, NRAS
SHC1 events in ERBB4 signaling (R-HSA-1250347) -5.150.0PTPN11, KRAS, NF1, CBL, NRAS
Signaling by PDGF (R-HSA-186797) -4.530.004PTPN11, KRAS, NF1, NRAS, CBL
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (R-HSA-2404192) -4.850.001PTPN11, KRAS, NF1, CBL, NRAS
p38MAPK events (R-HSA-171007) -9.280.005KRAS, NRAS
Signaling by Interleukins (R-HSA-449147) -4.710.0PTPN11, KRAS, NF1, NRAS, CBL
Cell surface interactions at the vascular wall (R-HSA-202733) -6.320.037PTPN11, KRAS, NRAS
Cytokine Signaling in Immune system (R-HSA-1280215) -3.740.002PTPN11, KRAS, NF1, CBL, NRAS
SOS-mediated signalling (R-HSA-112412) -5.150.0PTPN11, KRAS, NF1, NRAS, CBL
Signaling by ERBB4 (R-HSA-1236394) -4.70.002PTPN11, KRAS, NF1, CBL, NRAS
MAPK1/MAPK3 signaling (R-HSA-5684996) -5.110.0PTPN11, KRAS, NF1, NRAS, CBL
MAPK family signaling cascades (R-HSA-5683057) -4.890.001PTPN11, KRAS, NF1, NRAS, CBL
Signalling by NGF (R-HSA-166520) -4.230.015PTPN11, KRAS, NF1, CBL, NRAS
Signaling by FGFR4 (R-HSA-5654743) -4.690.002PTPN11, KRAS, NF1, CBL, NRAS
Signaling by FGFR3 (R-HSA-5654741) -4.690.002PTPN11, KRAS, NF1, NRAS, CBL
Signaling by FGFR (R-HSA-190236) -4.670.002PTPN11, KRAS, NF1, CBL, NRAS
Signaling by SCF-KIT (R-HSA-1433557) -4.730.002PTPN11, KRAS, NF1, NRAS, CBL
NCAM signaling for neurite out-growth (R-HSA-375165) -4.90.001PTPN11, KRAS, NF1, NRAS, CBL
DAP12 signaling (R-HSA-2424491) -4.640.005PTPN11, KRAS, NF1, CBL, NRAS
Interleukin-3, 5 and GM-CSF signaling (R-HSA-512988) -4.990.0PTPN11, KRAS, NF1, NRAS, CBL
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (R-HSA-1236382) -8.730.0CBL, KRAS, NRAS
Regulation of RAS by GAPs (R-HSA-5658442) -6.920.002NF1, KRAS, NRAS
Signalling to ERKs (R-HSA-187687) -5.040.001PTPN11, KRAS, NF1, NRAS, CBL
Signaling by FGFR4 in disease (R-HSA-5655291) -9.520.004KRAS, NRAS
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.187PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS, SETBP1
protein binding (GO:0005515) 0.467PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS, SETBP1
cation binding (GO:0043169) 1.43CBL, NF1, KRAS
organic cyclic compound binding (GO:0097159) 1.053SETBP1, KRAS, NRAS
ion binding (GO:0043167) 1.363NF1, CBL, KRAS
catalytic activity (GO:0003824) 1.053PTPN11, CBL, KRAS
macromolecular complex binding (GO:0044877) 2.613PTPN11, KRAS, NRAS
protein domain specific binding (GO:0019904) 3.323PTPN11, CBL, KRAS
protein complex binding (GO:0032403) 3.093PTPN11, KRAS, NRAS
heterocyclic compound binding (GO:1901363) 1.063SETBP1, KRAS, NRAS
purine ribonucleoside triphosphate binding (GO:0035639) 2.222KRAS, NRAS
enzyme binding (GO:0019899) 2.272PTPN11, CBL
enzyme activator activity (GO:0008047) 3.562NF1, ARHGAP26
molecular function regulator (GO:0098772) 2.512NF1, ARHGAP26
nucleoside phosphate binding (GO:1901265) 1.962KRAS, NRAS
nucleoside binding (GO:0001882) 2.212KRAS, NRAS
phospholipid binding (GO:0005543) 3.912NF1, ARHGAP26
nucleotide binding (GO:0000166) 1.962KRAS, NRAS
guanyl ribonucleotide binding (GO:0032561) 3.732KRAS, NRAS
transferase activity (GO:0016740) 1.952PTPN11, CBL
purine nucleoside binding (GO:0001883) 2.222KRAS, NRAS
ribonucleoside binding (GO:0032549) 2.222KRAS, NRAS
purine nucleotide binding (GO:0017076) 2.192KRAS, NRAS
metal ion binding (GO:0046872) 1.412CBL, KRAS
GTP binding (GO:0005525) 3.782KRAS, NRAS
hydrolase activity (GO:0016787) 1.92PTPN11, KRAS
enzyme regulator activity (GO:0030234) 2.852NF1, ARHGAP26
GTPase activator activity (GO:0005096) 4.112NF1, ARHGAP26
lipid binding (GO:0008289) 3.262NF1, ARHGAP26
protein kinase binding (GO:0019901) 3.442PTPN11, CBL
kinase binding (GO:0019900) 3.322PTPN11, CBL
nucleoside-triphosphatase regulator activity (GO:0060589) 3.922NF1, ARHGAP26
small molecule binding (GO:0036094) 1.892KRAS, NRAS
GTPase regulator activity (GO:0030695) 4.012NF1, ARHGAP26
carbohydrate derivative binding (GO:0097367) 2.032KRAS, NRAS
guanyl nucleotide binding (GO:0019001) 3.732KRAS, NRAS
purine ribonucleotide binding (GO:0032555) 2.22KRAS, NRAS
receptor binding (GO:0005102) 2.432PTPN11, CBL
purine ribonucleoside binding (GO:0032550) 2.222KRAS, NRAS
ribonucleotide binding (GO:0032553) 2.192KRAS, NRAS

NET-GE enrichment

Term New enriched termICP valueGenes
SH3/SH2 adaptor activity (GO:0005070) NEW5.790.0PTPN11, KRAS, CBL, NRAS
protein binding, bridging (GO:0030674) NEW4.680.0PTPN11, KRAS, ARHGAP26, NRAS, CBL
phosphatidylinositol 3-kinase binding (GO:0043548) NEW6.410.018CBL, NRAS
phosphatidylinositol phospholipase C activity (GO:0004435) NEW6.410.037PTPN11, NRAS
signaling adaptor activity (GO:0035591) NEW5.430.0PTPN11, KRAS, CBL, NRAS
phospholipase C activity (GO:0004629) NEW6.30.041PTPN11, NRAS
enzyme activator activity (GO:0008047) -3.560.01NF1, KRAS, PTPN11, ARHGAP26, CBL
protein domain specific binding (GO:0019904) -3.320.006PTPN11, KRAS, CBL, ARHGAP26
binding, bridging (GO:0060090) NEW4.570.0PTPN11, KRAS, ARHGAP26, NRAS, CBL
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
biological regulation (GO:0065007) 0.397PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS, MLLT11
regulation of cellular process (GO:0050794) 0.57PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS, MLLT11
regulation of response to stimulus (GO:0048583) 1.547PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS, MLLT11
regulation of biological process (GO:0050789) 0.457PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS, MLLT11
signal transduction (GO:0007165) 1.287PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS, MLLT11
positive regulation of response to stimulus (GO:0048584) 2.186PTPN11, NRAS, CBL, KRAS, NF1, MLLT11
regulation of signal transduction (GO:0009966) 1.846PTPN11, CBL, ARHGAP26, NF1, KRAS, MLLT11
cellular process (GO:0009987) 0.266PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS
cell surface receptor signaling pathway (GO:0007166) 2.096PTPN11, NRAS, CBL, KRAS, NF1, MLLT11
regulation of signaling (GO:0023051) 1.726PTPN11, CBL, ARHGAP26, NF1, KRAS, MLLT11
positive regulation of biological process (GO:0048518) 1.26PTPN11, NRAS, CBL, KRAS, NF1, MLLT11
regulation of cell communication (GO:0010646) 1.736PTPN11, CBL, ARHGAP26, NF1, KRAS, MLLT11
regulation of primary metabolic process (GO:0080090) 1.085PTPN11, KRAS, NF1, CBL, MLLT11
regulation of metabolic process (GO:0019222) 1.025PTPN11, KRAS, NF1, CBL, MLLT11
regulation of cellular metabolic process (GO:0031323) 1.075PTPN11, KRAS, NF1, MLLT11, CBL
positive regulation of signaling (GO:0023056) 2.415MLLT11, PTPN11, NF1, CBL, KRAS
intracellular signal transduction (GO:0035556) 2.395PTPN11, KRAS, NF1, NRAS, MLLT11
positive regulation of cell communication (GO:0010647) 2.415PTPN11, KRAS, NF1, CBL, MLLT11
single-organism process (GO:0044699) 0.485PTPN11, KRAS, NF1, ARHGAP26, NRAS
cellular protein metabolic process (GO:0044267) 1.635PTPN11, KRAS, NF1, CBL, NRAS
cellular macromolecule metabolic process (GO:0044260) 0.935PTPN11, KRAS, NF1, CBL, NRAS
positive regulation of signal transduction (GO:0009967) 2.55MLLT11, PTPN11, NF1, CBL, KRAS
organic substance metabolic process (GO:0071704) 0.635PTPN11, KRAS, NF1, CBL, NRAS
regulation of macromolecule metabolic process (GO:0060255) 1.085MLLT11, PTPN11, NF1, CBL, KRAS
cellular protein modification process (GO:0006464) 1.795PTPN11, KRAS, NF1, NRAS, CBL
macromolecule modification (GO:0043412) 1.735PTPN11, KRAS, NF1, NRAS, CBL
protein modification process (GO:0036211) 1.795PTPN11, KRAS, NF1, CBL, NRAS
single-organism cellular process (GO:0044763) 0.655PTPN11, KRAS, NF1, ARHGAP26, NRAS
metabolic process (GO:0008152) 0.585PTPN11, KRAS, NF1, NRAS, CBL
regulation of intracellular signal transduction (GO:1902531) 2.315NF1, KRAS, PTPN11, ARHGAP26, CBL
primary metabolic process (GO:0044238) 0.695PTPN11, KRAS, NF1, NRAS, CBL
protein metabolic process (GO:0019538) 1.455PTPN11, KRAS, NF1, CBL, NRAS
cellular metabolic process (GO:0044237) 0.695PTPN11, KRAS, NF1, CBL, NRAS
macromolecule metabolic process (GO:0043170) 0.835PTPN11, KRAS, NF1, CBL, NRAS
positive regulation of cellular process (GO:0048522) 1.35MLLT11, PTPN11, NF1, CBL, KRAS
positive regulation of metabolic process (GO:0009893) 1.744PTPN11, KRAS, NF1, MLLT11
phosphorylation (GO:0016310) 2.634PTPN11, KRAS, NF1, NRAS
positive regulation of cellular metabolic process (GO:0031325) 1.814PTPN11, KRAS, NF1, MLLT11
ERBB signaling pathway (GO:0038127) 5.364PTPN11, KRAS, CBL, NRAS
enzyme linked receptor protein signaling pathway (GO:0007167) 3.244PTPN11, KRAS, CBL, NRAS
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.544PTPN11, KRAS, CBL, NRAS
regulation of cell death (GO:0010941) 2.434NF1, KRAS, CBL, MLLT11
regulation of apoptotic process (GO:0042981) 2.54MLLT11, NF1, CBL, KRAS
cellular component organization or biogenesis (GO:0071840) 1.224PTPN11, KRAS, NF1, ARHGAP26
single-organism metabolic process (GO:0044710) 1.634PTPN11, KRAS, NF1, NRAS
cellular component organization (GO:0016043) 1.244PTPN11, KRAS, NF1, ARHGAP26
regulation of programmed cell death (GO:0043067) 2.494NF1, KRAS, CBL, MLLT11
regulation of immune system process (GO:0002682) 2.54PTPN11, KRAS, NF1, NRAS
positive regulation of catalytic activity (GO:0043085) 2.44PTPN11, KRAS, NF1, ARHGAP26
positive regulation of molecular function (GO:0044093) 2.234PTPN11, KRAS, NF1, ARHGAP26
regulation of cellular biosynthetic process (GO:0031326) 1.384CBL, KRAS, NF1, MLLT11
negative regulation of biological process (GO:0048519) 1.334PTPN11, KRAS, NF1, CBL
regulation of molecular function (GO:0065009) 1.784PTPN11, KRAS, NF1, ARHGAP26
regulation of biological quality (GO:0065008) 1.684MLLT11, PTPN11, NF1, KRAS
regulation of gene expression (GO:0010468) 1.374NF1, KRAS, CBL, MLLT11
developmental process (GO:0032502) 1.364PTPN11, KRAS, NF1, ARHGAP26
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.434MLLT11, CBL, NF1, KRAS
regulation of catalytic activity (GO:0050790) 1.974PTPN11, KRAS, NF1, ARHGAP26
regulation of biosynthetic process (GO:0009889) 1.374NF1, KRAS, CBL, MLLT11
epidermal growth factor receptor signaling pathway (GO:0007173) 5.724PTPN11, KRAS, CBL, NRAS
regulation of nitrogen compound metabolic process (GO:0051171) 1.364MLLT11, NF1, CBL, KRAS
anatomical structure development (GO:0048856) 1.584PTPN11, KRAS, NF1, ARHGAP26
phosphate-containing compound metabolic process (GO:0006796) 2.164PTPN11, KRAS, NF1, NRAS
phosphorus metabolic process (GO:0006793) 2.154PTPN11, KRAS, NF1, NRAS
negative regulation of cellular process (GO:0048523) 1.414PTPN11, NF1, CBL, KRAS
regulation of phosphate metabolic process (GO:0019220) 2.353PTPN11, NF1, KRAS
regulation of protein metabolic process (GO:0051246) 1.933PTPN11, NF1, KRAS
regulation of transport (GO:0051049) 2.243PTPN11, NF1, CBL
cell differentiation (GO:0030154) 2.143PTPN11, NF1, KRAS
cell development (GO:0048468) 3.283PTPN11, NF1, KRAS
actin cytoskeleton organization (GO:0030036) 4.13NF1, KRAS, ARHGAP26
regulation of cellular component organization (GO:0051128) 2.013PTPN11, CBL, MLLT11
negative regulation of signaling (GO:0023057) 2.653PTPN11, NF1, CBL
leukocyte migration (GO:0050900) 4.193PTPN11, KRAS, NRAS
negative regulation of cell communication (GO:0010648) 2.663PTPN11, NF1, CBL
positive regulation of phosphate metabolic process (GO:0045937) 2.783PTPN11, NF1, KRAS
regulation of localization (GO:0032879) 1.943PTPN11, NF1, CBL
anatomical structure morphogenesis (GO:0009653) 2.533PTPN11, NF1, KRAS
regulation of defense response (GO:0031347) 3.113PTPN11, KRAS, NRAS
regulation of MAPK cascade (GO:0043408) 3.223PTPN11, NF1, KRAS
regulation of protein serine/threonine kinase activity (GO:0071900) 3.583PTPN11, NF1, KRAS
positive regulation of macromolecule metabolic process (GO:0010604) 1.813PTPN11, KRAS, MLLT11
cellular developmental process (GO:0048869) 1.823PTPN11, NF1, KRAS
positive regulation of phosphorus metabolic process (GO:0010562) 2.783PTPN11, NF1, KRAS
regulation of kinase activity (GO:0043549) 3.073PTPN11, NF1, KRAS
MAPK cascade (GO:0000165) 3.913NF1, KRAS, NRAS
positive regulation of immune system process (GO:0002684) 2.963PTPN11, KRAS, NRAS
regulation of cellular protein metabolic process (GO:0032268) 1.993PTPN11, NF1, KRAS
signal transduction by protein phosphorylation (GO:0023014) 3.793NF1, KRAS, NRAS
regulation of protein modification process (GO:0031399) 2.323PTPN11, NF1, KRAS
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.463CBL, MLLT11, KRAS
regulation of small GTPase mediated signal transduction (GO:0051056) 4.083NF1, KRAS, ARHGAP26
protein phosphorylation (GO:0006468) 2.893NF1, KRAS, NRAS
multicellular organismal process (GO:0032501) 1.453PTPN11, NF1, KRAS
regulation of innate immune response (GO:0045088) 3.863PTPN11, KRAS, NRAS
actin filament-based process (GO:0030029) 3.943NF1, KRAS, ARHGAP26
regulation of protein kinase activity (GO:0045859) 3.153PTPN11, NF1, KRAS
regulation of nucleic acid-templated transcription (GO:1903506) 1.553CBL, MLLT11, KRAS
single-organism developmental process (GO:0044767) 1.493PTPN11, NF1, KRAS
regulation of immune response (GO:0050776) 2.983PTPN11, KRAS, NRAS
movement of cell or subcellular component (GO:0006928) 2.613PTPN11, KRAS, NRAS
locomotion (GO:0040011) 2.913PTPN11, KRAS, NRAS
regulation of RNA biosynthetic process (GO:2001141) 1.553CBL, MLLT11, KRAS
positive regulation of intracellular signal transduction (GO:1902533) 2.953PTPN11, CBL, KRAS
Ras protein signal transduction (GO:0007265) 4.763NF1, KRAS, NRAS
small GTPase mediated signal transduction (GO:0007264) 3.853NF1, KRAS, NRAS
regulation of phosphorylation (GO:0042325) 2.53PTPN11, NF1, KRAS
regulation of phosphorus metabolic process (GO:0051174) 2.353PTPN11, NF1, KRAS
cell migration (GO:0016477) 3.123PTPN11, KRAS, NRAS
cytoskeleton organization (GO:0007010) 3.223NF1, KRAS, ARHGAP26
organelle organization (GO:0006996) 2.023NF1, KRAS, ARHGAP26
single-multicellular organism process (GO:0044707) 1.783PTPN11, NF1, KRAS
cell motility (GO:0048870) 3.023PTPN11, KRAS, NRAS
response to stimulus (GO:0050896) 1.223PTPN11, NF1, KRAS
regulation of RNA metabolic process (GO:0051252) 1.523CBL, MLLT11, KRAS
regulation of MAP kinase activity (GO:0043405) 3.953PTPN11, NF1, KRAS
regulation of transferase activity (GO:0051338) 2.883PTPN11, NF1, KRAS
immune system process (GO:0002376) 2.293PTPN11, KRAS, NRAS
regulation of transcription, DNA-templated (GO:0006355) 1.563CBL, KRAS, MLLT11
single-organism organelle organization (GO:1902589) 2.683NF1, KRAS, ARHGAP26
regulation of macromolecule biosynthetic process (GO:0010556) 1.433CBL, KRAS, MLLT11
regulation of protein phosphorylation (GO:0001932) 2.573PTPN11, NF1, KRAS
regulation of response to stress (GO:0080134) 2.533PTPN11, KRAS, NRAS
regulation of intracellular protein transport (GO:0033157) 3.82PTPN11, NF1
regulation of secretion (GO:0051046) 3.22PTPN11, NF1
anatomical structure homeostasis (GO:0060249) 4.252PTPN11, KRAS
negative regulation of secretion (GO:0051048) 4.442PTPN11, NF1
regulation of intracellular transport (GO:0032386) 3.582PTPN11, NF1
learning (GO:0007612) 4.852NF1, KRAS
behavior (GO:0007610) 3.472NF1, KRAS
learning or memory (GO:0007611) 4.332NF1, KRAS
positive regulation of defense response (GO:0031349) 3.832KRAS, NRAS
negative regulation of cell adhesion (GO:0007162) 4.332PTPN11, NF1
regulation of neuron apoptotic process (GO:0043523) 4.472NF1, KRAS
cellular response to stimulus (GO:0051716) 1.972PTPN11, NF1
negative regulation of signal transduction (GO:0009968) 2.752NF1, CBL
regulation of apoptotic signaling pathway (GO:2001233) 3.832NF1, MLLT11
animal organ development (GO:0048513) 2.532PTPN11, NF1
negative regulation of response to stimulus (GO:0048585) 2.522NF1, CBL
regulation of cell proliferation (GO:0042127) 2.412NF1, KRAS
negative regulation of transport (GO:0051051) 3.62PTPN11, NF1
positive regulation of transport (GO:0051050) 2.92PTPN11, CBL
negative regulation of cell death (GO:0060548) 2.952CBL, KRAS
neuron projection guidance (GO:0097485) 4.432KRAS, NRAS
system process (GO:0003008) 2.32NF1, KRAS
positive regulation of phosphorylation (GO:0042327) 2.92PTPN11, KRAS
immune response-activating cell surface receptor signaling pathway (GO:0002429) 4.062KRAS, NRAS
homeostasis of number of cells within a tissue (GO:0048873) 6.332PTPN11, KRAS
homeostasis of number of cells (GO:0048872) 4.982PTPN11, KRAS
regulation of homeostatic process (GO:0032844) 3.652NF1, MLLT11
single-organism behavior (GO:0044708) 3.792NF1, KRAS
regulation of synaptic transmission, GABAergic (GO:0032228) 6.362NF1, KRAS
cellular response to stress (GO:0033554) 2.512PTPN11, NF1
negative regulation of secretion by cell (GO:1903531) 4.552PTPN11, NF1
visual behavior (GO:0007632) 5.822NF1, KRAS
positive regulation of apoptotic signaling pathway (GO:2001235) 4.582NF1, MLLT11
glial cell development (GO:0021782) 5.782NF1, KRAS
positive regulation of biosynthetic process (GO:0009891) 2.292NF1, MLLT11
regulation of synaptic plasticity (GO:0048167) 4.782NF1, KRAS
positive regulation of gene expression (GO:0010628) 2.352MLLT11, KRAS
regulation of Rac protein signal transduction (GO:0035020) 7.242NF1, KRAS
positive regulation of protein serine/threonine kinase activity (GO:0071902) 4.062PTPN11, KRAS
regulation of protein transport (GO:0051223) 3.122PTPN11, NF1
negative regulation of protein transport (GO:0051224) 4.442PTPN11, NF1
regulation of neuronal synaptic plasticity (GO:0048168) 5.842NF1, KRAS
positive regulation of transferase activity (GO:0051347) 3.312PTPN11, KRAS
positive regulation of GTPase activity (GO:0043547) 3.282NF1, ARHGAP26
positive regulation of hydrolase activity (GO:0051345) 2.912NF1, ARHGAP26
immune response-regulating cell surface receptor signaling pathway (GO:0002768) 3.962KRAS, NRAS
positive regulation of cellular component organization (GO:0051130) 2.682CBL, MLLT11
regulation of establishment of protein localization (GO:0070201) 3.022PTPN11, NF1
regulation of developmental process (GO:0050793) 2.12PTPN11, NF1
positive regulation of MAPK cascade (GO:0043410) 3.572PTPN11, KRAS
response to stress (GO:0006950) 1.82PTPN11, NF1
associative learning (GO:0008306) 5.442NF1, KRAS
regulation of multicellular organismal process (GO:0051239) 1.872PTPN11, NF1
astrocyte development (GO:0014002) 6.92NF1, KRAS
regulation of neuron death (GO:1901214) 4.192NF1, KRAS
establishment of localization (GO:0051234) 1.482NF1, NRAS
phosphatidylinositol-mediated signaling (GO:0048015) 4.932PTPN11, NF1
inositol lipid-mediated signaling (GO:0048017) 4.912PTPN11, NF1
regulation of hydrolase activity (GO:0051336) 2.532NF1, ARHGAP26
immune response-activating signal transduction (GO:0002757) 3.82KRAS, NRAS
brain development (GO:0007420) 4.242PTPN11, NF1
positive regulation of protein modification process (GO:0031401) 2.72PTPN11, KRAS
cognition (GO:0050890) 4.22NF1, KRAS
activation of innate immune response (GO:0002218) 4.412KRAS, NRAS
regulation of nucleocytoplasmic transport (GO:0046822) 4.332PTPN11, NF1
positive regulation of kinase activity (GO:0033674) 3.542PTPN11, KRAS
regulation of synapse structure or activity (GO:0050803) 4.772NF1, KRAS
response to radiation (GO:0009314) 3.692NF1, KRAS
regulation of cell adhesion (GO:0030155) 3.272PTPN11, NF1
regulation of Ras protein signal transduction (GO:0046578) 4.492NF1, KRAS
modulation of synaptic transmission (GO:0050804) 4.092NF1, KRAS
regulation of cellular protein localization (GO:1903827) 3.432PTPN11, NF1
positive regulation of MAP kinase activity (GO:0043406) 4.392PTPN11, KRAS
response to light stimulus (GO:0009416) 4.082NF1, KRAS
regulation of secretion by cell (GO:1903530) 3.282PTPN11, NF1
axon guidance (GO:0007411) 4.442KRAS, NRAS
ERBB2 signaling pathway (GO:0038128) 6.092KRAS, NRAS
fibroblast growth factor receptor signaling pathway (GO:0008543) 5.32PTPN11, CBL
visual learning (GO:0008542) 5.922NF1, KRAS
regulation of protein localization (GO:0032880) 2.882PTPN11, NF1
forebrain astrocyte development (GO:0021897) 9.042NF1, KRAS
negative regulation of multicellular organismal process (GO:0051241) 2.842PTPN11, NF1
positive regulation of protein metabolic process (GO:0051247) 2.432PTPN11, KRAS
positive regulation of cellular protein metabolic process (GO:0032270) 2.492PTPN11, KRAS
negative regulation of establishment of protein localization (GO:1904950) 4.392PTPN11, NF1
innate immune response activating cell surface receptor signaling pathway (GO:0002220) 5.072KRAS, NRAS
stimulatory C-type lectin receptor signaling pathway (GO:0002223) 5.092KRAS, NRAS
positive regulation of cell proliferation (GO:0008284) 3.012NF1, KRAS
heart development (GO:0007507) 4.242PTPN11, NF1
neurological system process (GO:0050877) 2.642NF1, KRAS
negative regulation of cell differentiation (GO:0045596) 3.332NF1, KRAS
regulation of cell differentiation (GO:0045595) 2.422NF1, KRAS
Fc-epsilon receptor signaling pathway (GO:0038095) 4.842KRAS, NRAS
tissue homeostasis (GO:0001894) 4.782PTPN11, KRAS
regulation of phosphatidylinositol 3-kinase signaling (GO:0014066) 4.792PTPN11, CBL
Fc receptor signaling pathway (GO:0038093) 4.452KRAS, NRAS
positive regulation of immune response (GO:0050778) 3.42KRAS, NRAS
system development (GO:0048731) 2.922NF1, ARHGAP26
positive regulation of protein kinase activity (GO:0045860) 3.612PTPN11, KRAS
regulation of cellular localization (GO:0060341) 3.032PTPN11, NF1
positive regulation of cellular biosynthetic process (GO:0031328) 2.32NF1, MLLT11
innate immune response-activating signal transduction (GO:0002758) 4.452KRAS, NRAS
apoptotic signaling pathway (GO:0097190) 4.122NF1, MLLT11
extrinsic apoptotic signaling pathway (GO:0097191) 5.162NF1, MLLT11
homeostatic process (GO:0042592) 2.612PTPN11, KRAS
positive regulation of cell death (GO:0010942) 3.322NF1, MLLT11
regulation of long-term neuronal synaptic plasticity (GO:0048169) 6.552NF1, KRAS
positive regulation of apoptotic process (GO:0043065) 3.382NF1, MLLT11
negative regulation of apoptotic process (GO:0043066) 3.042CBL, KRAS
negative regulation of programmed cell death (GO:0043069) 3.022CBL, KRAS
positive regulation of programmed cell death (GO:0043068) 3.382NF1, MLLT11
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352NF1, MLLT11
positive regulation of innate immune response (GO:0045089) 4.222KRAS, NRAS
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292NF1, MLLT11
regulation of GTPase activity (GO:0043087) 3.212NF1, ARHGAP26
cell communication (GO:0007154) 3.042NF1, KRAS
localization (GO:0051179) 1.42NF1, NRAS
immune response-regulating signaling pathway (GO:0002764) 3.722KRAS, NRAS
response to abiotic stimulus (GO:0009628) 2.82NF1, KRAS
activation of immune response (GO:0002253) 3.672KRAS, NRAS
positive regulation of protein phosphorylation (GO:0001934) 2.952PTPN11, KRAS

NET-GE enrichment

Term New enriched termICP valueGenes
cellular response to growth factor stimulus (GO:0071363) NEW4.270.018PTPN11, KRAS, CBL, NRAS
visual behavior (GO:0007632) -5.820.028NF1, KRAS, NRAS
positive regulation of catalytic activity (GO:0043085) -2.40.029PTPN11, KRAS, NF1, ARHGAP26, NRAS
response to insulin (GO:0032868) NEW4.720.003PTPN11, KRAS, NF1, CBL, NRAS
regulation of cell death (GO:0010941) -2.430.027MLLT11, NF1, NRAS, KRAS, CBL
positive regulation of cell communication (GO:0010647) -2.410.01PTPN11, KRAS, NF1, NRAS, CBL
regulation of signaling (GO:0023051) -1.720.001PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS, MLLT11
regulation of Ras protein signal transduction (GO:0046578) -4.490.005PTPN11, KRAS, NF1, CBL, NRAS
activation of protein kinase activity (GO:0032147) NEW4.080.004PTPN11, KRAS, NF1, CBL, NRAS
actin cytoskeleton organization (GO:0030036) -4.10.001PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS
learning or memory (GO:0007611) -4.330.002PTPN11, KRAS, NF1, NRAS, CBL
positive regulation of signaling (GO:0023056) -2.410.01PTPN11, KRAS, NF1, NRAS, CBL
regulation of synaptic plasticity (GO:0048167) -4.780.006PTPN11, KRAS, NF1, NRAS
regulation of neuron apoptotic process (GO:0043523) -4.470.024NF1, KRAS, NRAS
regulation of Rac protein signal transduction (GO:0035020) -7.240.0NF1, KRAS, NRAS
ERBB signaling pathway (GO:0038127) -5.360.0PTPN11, KRAS, CBL, NRAS
positive regulation of Rac protein signal transduction (GO:0035022) NEW8.630.0KRAS, NRAS
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) -3.540.018PTPN11, KRAS, CBL, NRAS
cellular response to insulin stimulus (GO:0032869) NEW5.290.026PTPN11, KRAS, CBL, NRAS
axon guidance (GO:0007411) -4.440.032PTPN11, KRAS, NF1, CBL, NRAS
intracellular signal transduction (GO:0035556) -2.390.001PTPN11, NRAS, ARHGAP26, NF1, KRAS, MLLT11
regulation of cell communication (GO:0010646) -1.730.001PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS, MLLT11
fibroblast growth factor receptor signaling pathway (GO:0008543) -5.30.0PTPN11, KRAS, CBL, NRAS
regulation of neuronal synaptic plasticity (GO:0048168) -5.840.0NF1, KRAS, NRAS
signal transduction by phosphorylation (GO:0023014) -3.790.046PTPN11, KRAS, NF1, NRAS
regulation of MAPK cascade (GO:0043408) -3.220.015PTPN11, KRAS, NF1, NRAS
regulation of signal transduction (GO:0009966) -1.840.0PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS, MLLT11
regulation of apoptotic process (GO:0042981) -2.50.021CBL, KRAS, NF1, NRAS, MLLT11
negative regulation of phosphorus metabolic process (GO:0010563) NEW3.450.001PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS
MAPK cascade (GO:0000165) -3.910.023PTPN11, KRAS, NF1, NRAS
cellular response to fibroblast growth factor stimulus (GO:0044344) NEW6.40.0PTPN11, KRAS, CBL, NRAS
visual learning (GO:0008542) -5.920.017NF1, KRAS, NRAS
Ras protein signal transduction (GO:0007265) -4.760.0PTPN11, KRAS, NF1, CBL, NRAS
epithelial tube branching involved in lung morphogenesis (GO:0060441) NEW6.90.015KRAS, NRAS
regulation of long-term neuronal synaptic plasticity (GO:0048169) -6.550.0NF1, KRAS, NRAS
neuron projection guidance (GO:0097485) -4.430.032PTPN11, KRAS, NF1, CBL, NRAS
response to peptide hormone (GO:0043434) NEW4.060.027PTPN11, KRAS, NF1, CBL, NRAS
negative regulation of MAPK cascade (GO:0043409) NEW4.740.008PTPN11, KRAS, NF1, CBL
regulation of response to stimulus (GO:0048583) -1.540.003PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS, MLLT11
regulation of neurotransmitter transport (GO:0051588) NEW5.550.048PTPN11, NF1, KRAS
learning (GO:0007612) -4.850.006NF1, KRAS, NRAS
positive regulation of small GTPase mediated signal transduction (GO:0051057) NEW6.040.048KRAS, NRAS
regulation of small GTPase mediated signal transduction (GO:0051056) -4.080.0PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS
regulation of programmed cell death (GO:0043067) -2.490.022MLLT11, NF1, NRAS, KRAS, CBL
actin filament-based process (GO:0030029) -3.940.0PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS
negative regulation of phosphate metabolic process (GO:0045936) NEW3.450.001PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS
apoptotic signaling pathway (GO:0097190) -4.120.012PTPN11, KRAS, NF1, CBL, MLLT11
regulation of protein kinase activity (GO:0045859) -3.150.043PTPN11, KRAS, NF1, NRAS
insulin receptor signaling pathway (GO:0008286) NEW5.330.012PTPN11, KRAS, CBL, NRAS
small GTPase mediated signal transduction (GO:0007264) -3.850.009PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS
positive regulation of Ras protein signal transduction (GO:0046579) NEW6.20.035KRAS, NRAS
associative learning (GO:0008306) -5.440.001NF1, KRAS, NRAS
epidermal growth factor receptor signaling pathway (GO:0007173) -5.720.016PTPN11, KRAS, CBL, NRAS
negative regulation of intracellular signal transduction (GO:1902532) NEW3.630.029ARHGAP26, PTPN11, NF1, KRAS, CBL
positive regulation of intracellular signal transduction (GO:1902533) -2.950.043PTPN11, KRAS, CBL, NRAS
regulation of neuron death (GO:1901214) -4.190.036NF1, KRAS, NRAS
regulation of synaptic transmission (GO:0050804) -4.090.048PTPN11, KRAS, NF1, NRAS, CBL
negative regulation of phosphorylation (GO:0042326) NEW3.70.0PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS
cytoskeleton organization (GO:0007010) -3.220.01PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS
single-organism behavior (GO:0044708) -3.790.047PTPN11, KRAS, NF1, CBL, NRAS
cognition (GO:0050890) -4.20.004PTPN11, KRAS, NF1, NRAS, CBL
leukocyte migration (GO:0050900) -4.190.038PTPN11, KRAS, NRAS
regulation of synaptic transmission, GABAergic (GO:0032228) -6.360.0NF1, KRAS, NRAS
response to growth factor (GO:0070848) NEW4.140.021PTPN11, KRAS, CBL, NRAS
response to peptide (GO:1901652) NEW3.940.035PTPN11, KRAS, NF1, CBL, NRAS
positive regulation of signal transduction (GO:0009967) -2.50.008PTPN11, KRAS, NF1, NRAS, CBL
response to fibroblast growth factor (GO:0071774) NEW6.170.0PTPN11, KRAS, CBL, NRAS
regulation of intracellular signal transduction (GO:1902531) -2.310.0PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.288PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS, SETBP1, MLLT11
intracellular organelle (GO:0043229) 0.518PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS, SETBP1, MLLT11
cell part (GO:0044464) 0.118PTPN11, NRAS, CBL, KRAS, NF1, ARHGAP26, SETBP1, MLLT11
organelle (GO:0043226) 0.48PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS, SETBP1, MLLT11
membrane-bounded organelle (GO:0043227) 0.477PTPN11, NRAS, CBL, KRAS, NF1, SETBP1, MLLT11
intracellular membrane-bounded organelle (GO:0043231) 0.67PTPN11, NRAS, CBL, KRAS, NF1, SETBP1, MLLT11
cytoplasm (GO:0005737) 1.016PTPN11, CBL, ARHGAP26, NF1, KRAS, MLLT11
cytoplasmic part (GO:0044444) 0.826PTPN11, NRAS, CBL, ARHGAP26, NF1, KRAS
nucleus (GO:0005634) 1.075SETBP1, MLLT11, NF1, PTPN11, CBL
cytosol (GO:0005829) 1.685CBL, KRAS, NF1, PTPN11, ARHGAP26
membrane (GO:0016020) 0.684NF1, KRAS, CBL, NRAS
intracellular non-membrane-bounded organelle (GO:0043232) 1.763NF1, MLLT11, ARHGAP26
intracellular (GO:0005622) 2.373MLLT11, NRAS, KRAS
intracellular organelle part (GO:0044446) 0.813NF1, MLLT11, NRAS
non-membrane-bounded organelle (GO:0043228) 1.763NF1, MLLT11, ARHGAP26
plasma membrane (GO:0005886) 1.393CBL, KRAS, NRAS
membrane part (GO:0044425) 0.953NF1, CBL, KRAS
plasma membrane part (GO:0044459) 1.953CBL, NF1, KRAS
organelle part (GO:0044422) 0.793NF1, MLLT11, NRAS
cytoskeleton (GO:0005856) 2.552MLLT11, ARHGAP26
protein complex (GO:0043234) 1.512PTPN11, CBL
macromolecular complex (GO:0032991) 1.352PTPN11, CBL
anchoring junction (GO:0070161) 3.612KRAS, ARHGAP26
mitochondrion (GO:0005739) 2.422PTPN11, KRAS
adherens junction (GO:0005912) 3.662KRAS, ARHGAP26
cell-substrate adherens junction (GO:0005924) 3.832KRAS, ARHGAP26
focal adhesion (GO:0005925) 3.832KRAS, ARHGAP26
cell junction (GO:0030054) 2.752KRAS, ARHGAP26
cell-substrate junction (GO:0030055) 3.822KRAS, ARHGAP26

NET-GE enrichment

Term New enriched termICP valueGenes
cytosolic part (GO:0044445) NEW4.340.046PTPN11, CBL, KRAS
intracellular (GO:0005622) -2.370.001NRAS, CBL, ARHGAP26, NF1, KRAS, MLLT11