Disease table of ADAMS-OLIVER SYNDROME OMIM ID: PS100300

Gene-disease associations table

GeneAssociated with ADAMS-OLIVER SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
EOGTClinVar, OMIM, HUMSAVARHGNC link3p14.11PS100300
RBPJClinVar, OMIM, HUMSAVARHGNC link4p15.21PS100300
DOCK6ClinVar, OMIMHGNC link19p13.21PS100300
NOTCH1ClinVar, OMIM, HUMSAVARHGNC link9q34.36PS109730, 130020, 154700, 234750, 140500, PS100300
ARHGAP31ClinVar, OMIMHGNC link3q13.321PS100300
DLL4ClinVar, OMIMHGNC link15q15.11PS100300

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
32EOGT, ARHGAP31
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
RBPJYES3IL6, NFKB1, PTEN0
SIRT1NO43ACAN, TBX3, ESRRG, EZH2, CFLAR, NR1I2, FOXO3, SELE, HSF1, ABCB1, TP73, CCND1, NR5A2, CFH, HYOU1, IL1B, SHC1, COL1A2, NBN, CDKN1A, CTNNB1, MCL1, TNFRSF10B, BCL11A, CDH1, PARP1, ICAM1, PAX6, DLL4, SIRT6, NOTCH1, WRN, ADAMTS5, NDRG1, PER1, TNF, MMP9, COL10A1, TP53, EGLN1, MYC, PPARG, HIF1A2NOTCH1, DLL4
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
NOTCH1YES1SIRT10
DLL4YES1SIRT10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
EOGTRBPJNo1APP
EOGTNOTCH1No1APP
RBPJDOCK6No1XPO1
RBPJNOTCH1Yes21KDM1A, RUNX3, NOTCH1, GSK3B, SMARCA4, MED23, CAMK4, CHD4, KAT5, NOTCH2, CDC27, SMARCA5, PHF8, RND3, MAML2, MAML3, USP7, NOTCH3, MAML1, SNW1, APP
DOCK6NOTCH1No1MOB1A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
RBPJNOTCH1Yesactivation, binding43KAT2B, SOX9, CCNC, TP53, CDK8, HDAC9, PTCRA, SNW1, NCOR1, KDM1A, NOTCH3, TBL1X, CTBP1, HEY1, HDAC3, NCOR2, HDAC7, RBBP8, SKP2, HDAC5, CDKN1A, TBL1XR1, HDAC1, HDAC10, HES1, SPEN, MYOD1, EP300, MYC, SMARCC1, CREBBP, GATA3, IL4, MAML1, HES5, HEY2, IL6, MAML2, MAML3, HEYL, CCND1, ASCL1, NOTCH4
RBPJDLL4No-5NOTCH1, NOTCH4, HEY1, ASCL1, NOTCH3
DOCK6NOTCH1No-1AKT1
DOCK6ARHGAP31No-1CDC42
NOTCH1ARHGAP31No-1RHOU
NOTCH1DLL4Yesactivation, expression19APH1B, EFNB2, CTNNB1, NOTCH3, JAG1, NOTCH4, HEY1, NCSTN, RPS27A, DLL1, JAG2, PSENEN, MMP9, ADAM10, KDR, UBC, UBB, ASCL1, UBA52

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
RBPJNOTCH1YesNotch1-fraction 30 complex;MAML1-RBP-Jkappa-Notch1 complex;HES1 promoter-Notch enhancer complex;YY1-Notch1-RBP-Jkappa complex;RBPJ-NotchIC-Mastermind complex;RBP-Jkappa-Notch1 complex12POLR2A, SUPT6H, EP300, YY1, MED1, CDK8, CDK9, INPP5K, SUPT16H, CDK7, MAML1, CCNT1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
RBPJNOTCH1Yes2NOTCH1, RBPJ

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Notch signaling pathwayhsa043307.123NOTCH1, DLL4, RBPJ

NET-GE enrichment

Term New enriched termICP valueGenes
Notch signaling pathway (hsa04330) -7.120.0NOTCH1, DLL4, RBPJ
Other types of O-glycan biosynthesis (hsa00514) NEW7.720.019NOTCH1, EOGT
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signal TransductionR-HSA-1625821.784NOTCH1, ARHGAP31, DLL4, RBPJ
Signaling by NOTCH1R-HSA-19801436.813NOTCH1, DLL4, RBPJ
Diseases of signal transductionR-HSA-56632024.893NOTCH1, DLL4, RBPJ
Signaling by NOTCH1 in CancerR-HSA-26446037.153NOTCH1, DLL4, RBPJ
Signaling by NOTCH1 PEST Domain Mutants in CancerR-HSA-26446027.153NOTCH1, DLL4, RBPJ
Signaling by NOTCHR-HSA-1571186.23NOTCH1, DLL4, RBPJ
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerR-HSA-28948587.153NOTCH1, DLL4, RBPJ
Constitutive Signaling by NOTCH1 PEST Domain MutantsR-HSA-26446067.153NOTCH1, DLL4, RBPJ
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsR-HSA-28948627.153NOTCH1, DLL4, RBPJ
DiseaseR-HSA-16436853.333NOTCH1, DLL4, RBPJ
Constitutive Signaling by NOTCH1 HD Domain MutantsR-HSA-26912329.082NOTCH1, DLL4
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsR-HSA-21074410.182NOTCH1, RBPJ
Pre-NOTCH Expression and ProcessingR-HSA-19124227.492NOTCH1, RBPJ
Signaling by NOTCH2R-HSA-19801457.982DLL4, RBPJ
Generic Transcription PathwayR-HSA-2124363.862NOTCH1, RBPJ
Gene ExpressionR-HSA-741602.722NOTCH1, RBPJ
Pre-NOTCH Transcription and TranslationR-HSA-19124088.122NOTCH1, RBPJ
Signaling by NOTCH1 HD Domain Mutants in CancerR-HSA-26912309.082NOTCH1, DLL4
NOTCH1 Intracellular Domain Regulates TranscriptionR-HSA-21229477.432NOTCH1, RBPJ
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation MutantR-HSA-266082610.182NOTCH1, DLL4
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation MutantR-HSA-266082510.182NOTCH1, DLL4
Activated NOTCH1 Transmits Signal to the NucleusR-HSA-21229488.082NOTCH1, DLL4
Notch-HLH transcription pathwayR-HSA-3500549.282NOTCH1, RBPJ
Developmental BiologyR-HSA-12667383.482NOTCH1, RBPJ
Regulation of beta-cell developmentR-HSA-1867127.982NOTCH1, RBPJ

NET-GE enrichment

Term New enriched termICP valueGenes
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells (R-HSA-210744) -10.180.0NOTCH1, RBPJ
Signaling by NOTCH (R-HSA-157118) -6.20.023NOTCH1, DLL4, RBPJ
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant (R-HSA-2660826) -10.180.0NOTCH1, DLL4
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant (R-HSA-2660825) -10.180.0NOTCH1, DLL4
Notch-HLH transcription pathway (R-HSA-350054) -9.280.004NOTCH1, RBPJ
Pre-NOTCH Expression and Processing (R-HSA-1912422) -7.490.011NOTCH1, RBPJ
Signaling by NOTCH4 (R-HSA-1980150) NEW9.520.003NOTCH1, DLL4
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (R-HSA-2894862) -7.150.001NOTCH1, DLL4, RBPJ
Constitutive Signaling by NOTCH1 HD Domain Mutants (R-HSA-2691232) -9.080.004NOTCH1, DLL4
Signaling by NOTCH1 HD Domain Mutants in Cancer (R-HSA-2691230) -9.080.004NOTCH1, DLL4
Diseases of signal transduction (R-HSA-5663202) -4.890.014NOTCH1, DLL4, RBPJ
NOTCH1 Intracellular Domain Regulates Transcription (R-HSA-2122947) -7.430.012NOTCH1, RBPJ
NOTCH2 intracellular domain regulates transcription (R-HSA-2197563) NEW9.40.007NOTCH1, RBPJ
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948) -8.080.02NOTCH1, DLL4
Signaling by NOTCH2 (R-HSA-1980145) -7.980.0NOTCH1, DLL4, RBPJ
Signaling by NOTCH1 (R-HSA-1980143) -6.810.0NOTCH1, DLL4, RBPJ
Regulation of beta-cell development (R-HSA-186712) -7.980.006NOTCH1, RBPJ
Pre-NOTCH Transcription and Translation (R-HSA-1912408) -8.120.005NOTCH1, RBPJ
Signaling by NOTCH1 PEST Domain Mutants in Cancer (R-HSA-2644602) -7.150.001NOTCH1, DLL4, RBPJ
Constitutive Signaling by NOTCH1 PEST Domain Mutants (R-HSA-2644606) -7.150.001NOTCH1, DLL4, RBPJ
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (R-HSA-2894858) -7.150.001NOTCH1, DLL4, RBPJ
Signaling by NOTCH1 in Cancer (R-HSA-2644603) -7.150.001NOTCH1, DLL4, RBPJ
NOTCH2 Activation and Transmission of Signal to the Nucleus (R-HSA-2979096) NEW8.590.016NOTCH1, DLL4
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.184NOTCH1, ARHGAP31, DLL4, RBPJ
protein binding (GO:0005515) 0.464NOTCH1, ARHGAP31, DLL4, RBPJ
molecular function regulator (GO:0098772) 2.513NOTCH1, ARHGAP31, DOCK6
cation binding (GO:0043169) 1.42NOTCH1, DLL4
chromatin binding (GO:0003682) 3.642NOTCH1, RBPJ
core promoter binding (GO:0001047) 4.712NOTCH1, RBPJ
sequence-specific DNA binding (GO:0043565) 2.792NOTCH1, RBPJ
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.652NOTCH1, RBPJ
organic cyclic compound binding (GO:0097159) 1.052NOTCH1, RBPJ
enzyme regulator activity (GO:0030234) 2.852ARHGAP31, NOTCH1
regulatory region DNA binding (GO:0000975) 3.032NOTCH1, RBPJ
regulatory region nucleic acid binding (GO:0001067) 3.032NOTCH1, RBPJ
ion binding (GO:0043167) 1.362NOTCH1, DLL4
catalytic activity (GO:0003824) 1.052EOGT, RBPJ
transcription regulatory region DNA binding (GO:0044212) 3.032NOTCH1, RBPJ
macromolecular complex binding (GO:0044877) 2.612NOTCH1, RBPJ
nucleic acid binding transcription factor activity (GO:0001071) 2.652NOTCH1, RBPJ
nucleic acid binding (GO:0003676) 1.442NOTCH1, RBPJ
DNA binding (GO:0003677) 1.922NOTCH1, RBPJ
Notch binding (GO:0005112) 6.852NOTCH1, DLL4
receptor binding (GO:0005102) 2.432NOTCH1, DLL4
metal ion binding (GO:0046872) 1.412NOTCH1, DLL4
heterocyclic compound binding (GO:1901363) 1.062NOTCH1, RBPJ
calcium ion binding (GO:0005509) 3.172NOTCH1, DLL4

NET-GE enrichment

Term New enriched termICP valueGenes
metalloendopeptidase activity (GO:0004222) NEW5.020.015NOTCH1, DLL4, RBPJ
Notch binding (GO:0005112) -6.850.007NOTCH1, DLL4
core promoter binding (GO:0001047) -4.710.032NOTCH1, RBPJ
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of cellular process (GO:0050794) 0.55NOTCH1, ARHGAP31, DLL4, DOCK6, RBPJ
biological regulation (GO:0065007) 0.395NOTCH1, DOCK6, DLL4, ARHGAP31, RBPJ
regulation of biological process (GO:0050789) 0.455NOTCH1, ARHGAP31, DOCK6, RBPJ, DLL4
single-organism process (GO:0044699) 0.485NOTCH1, DOCK6, DLL4, RBPJ, EOGT
signal transduction (GO:0007165) 1.285NOTCH1, DOCK6, DLL4, ARHGAP31, RBPJ
primary metabolic process (GO:0044238) 0.694NOTCH1, DLL4, RBPJ, EOGT
multicellular organismal process (GO:0032501) 1.454NOTCH1, DOCK6, DLL4, RBPJ
single-multicellular organism process (GO:0044707) 1.784NOTCH1, DOCK6, RBPJ, DLL4
cellular macromolecule metabolic process (GO:0044260) 0.934NOTCH1, DLL4, RBPJ, EOGT
regulation of signal transduction (GO:0009966) 1.844NOTCH1, ARHGAP31, DLL4, RBPJ
cellular process (GO:0009987) 0.264NOTCH1, EOGT, DLL4, RBPJ
regulation of response to stimulus (GO:0048583) 1.544NOTCH1, ARHGAP31, DLL4, RBPJ
cellular metabolic process (GO:0044237) 0.694NOTCH1, DLL4, RBPJ, EOGT
macromolecule metabolic process (GO:0043170) 0.834NOTCH1, DLL4, RBPJ, EOGT
organic substance metabolic process (GO:0071704) 0.634NOTCH1, DLL4, RBPJ, EOGT
single-organism cellular process (GO:0044763) 0.654NOTCH1, DLL4, RBPJ, EOGT
metabolic process (GO:0008152) 0.584NOTCH1, DLL4, RBPJ, EOGT
regulation of signaling (GO:0023051) 1.724NOTCH1, ARHGAP31, DLL4, RBPJ
regulation of cell communication (GO:0010646) 1.734NOTCH1, ARHGAP31, DLL4, RBPJ
regulation of primary metabolic process (GO:0080090) 1.083NOTCH1, DLL4, RBPJ
regulation of metabolic process (GO:0019222) 1.023NOTCH1, DLL4, RBPJ
positive regulation of response to stimulus (GO:0048584) 2.183NOTCH1, DLL4, RBPJ
cell surface receptor signaling pathway (GO:0007166) 2.093NOTCH1, DLL4, RBPJ
heart trabecula morphogenesis (GO:0061384) 7.093NOTCH1, DLL4, RBPJ
trabecula morphogenesis (GO:0061383) 6.963NOTCH1, DLL4, RBPJ
cellular response to stimulus (GO:0051716) 1.973NOTCH1, DLL4, RBPJ
Notch signaling pathway (GO:0007219) 4.993NOTCH1, DLL4, RBPJ
negative regulation of macromolecule metabolic process (GO:0010605) 2.013NOTCH1, DLL4, RBPJ
positive regulation of macromolecule metabolic process (GO:0010604) 1.813NOTCH1, DLL4, RBPJ
morphogenesis of an endothelium (GO:0003159) 7.243NOTCH1, DLL4, RBPJ
positive regulation of signal transduction (GO:0009967) 2.53NOTCH1, DLL4, RBPJ
blood vessel morphogenesis (GO:0048514) 5.323NOTCH1, DLL4, RBPJ
positive regulation of biological process (GO:0048518) 1.23NOTCH1, DLL4, RBPJ
negative regulation of biological process (GO:0048519) 1.333NOTCH1, DLL4, RBPJ
regulation of cell proliferation (GO:0042127) 2.413NOTCH1, DLL4, RBPJ
regulation of macromolecule metabolic process (GO:0060255) 1.083NOTCH1, DLL4, RBPJ
regulation of RNA biosynthetic process (GO:2001141) 1.553NOTCH1, DLL4, RBPJ
regulation of molecular function (GO:0065009) 1.783NOTCH1, ARHGAP31, DOCK6
immune system process (GO:0002376) 2.293NOTCH1, DLL4, RBPJ
muscle tissue morphogenesis (GO:0060415) 5.623NOTCH1, DLL4, RBPJ
negative regulation of metabolic process (GO:0009892) 1.933NOTCH1, DLL4, RBPJ
positive regulation of metabolic process (GO:0009893) 1.743NOTCH1, DLL4, RBPJ
negative regulation of biosynthetic process (GO:0009890) 2.473NOTCH1, DLL4, RBPJ
regulation of anatomical structure morphogenesis (GO:0022603) 2.793NOTCH1, DLL4, RBPJ
negative regulation of gene expression (GO:0010629) 2.483NOTCH1, DLL4, RBPJ
positive regulation of gene expression (GO:0010628) 2.353NOTCH1, DLL4, RBPJ
neuron fate commitment (GO:0048663) 6.123NOTCH1, DLL4, RBPJ
cardiac chamber morphogenesis (GO:0003206) 6.363NOTCH1, DLL4, RBPJ
cardiac ventricle morphogenesis (GO:0003208) 6.553NOTCH1, DLL4, RBPJ
cell surface receptor signaling pathway involved in heart development (GO:0061311) 6.963NOTCH1, DLL4, RBPJ
anatomical structure formation involved in morphogenesis (GO:0048646) 3.013NOTCH1, DLL4, RBPJ
Notch signaling involved in heart development (GO:0061314) 7.533NOTCH1, DLL4, RBPJ
regulation of developmental process (GO:0050793) 2.13NOTCH1, DLL4, RBPJ
regulation of catalytic activity (GO:0050790) 1.973NOTCH1, ARHGAP31, DOCK6
regulation of biosynthetic process (GO:0009889) 1.373NOTCH1, DLL4, RBPJ
regulation of multicellular organismal process (GO:0051239) 1.873NOTCH1, DLL4, RBPJ
negative regulation of RNA biosynthetic process (GO:1902679) 2.73NOTCH1, DLL4, RBPJ
cell fate commitment (GO:0045165) 4.723NOTCH1, DLL4, RBPJ
response to stimulus (GO:0050896) 1.223NOTCH1, DLL4, RBPJ
regulation of transcription, DNA-templated (GO:0006355) 1.563NOTCH1, DLL4, RBPJ
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.243NOTCH1, DLL4, RBPJ
cellular developmental process (GO:0048869) 1.823NOTCH1, DLL4, RBPJ
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.533NOTCH1, DLL4, RBPJ
cell differentiation (GO:0030154) 2.143NOTCH1, DLL4, RBPJ
positive regulation of signaling (GO:0023056) 2.413NOTCH1, DLL4, RBPJ
positive regulation of cell communication (GO:0010647) 2.413NOTCH1, DLL4, RBPJ
anatomical structure morphogenesis (GO:0009653) 2.533NOTCH1, DLL4, RBPJ
ventricular trabecula myocardium morphogenesis (GO:0003222) 7.333NOTCH1, DLL4, RBPJ
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.123NOTCH1, DLL4, RBPJ
negative regulation of multicellular organismal process (GO:0051241) 2.843NOTCH1, DLL4, RBPJ
epithelial tube morphogenesis (GO:0060562) 5.123NOTCH1, DLL4, RBPJ
positive regulation of cell proliferation (GO:0008284) 3.013NOTCH1, DLL4, RBPJ
negative regulation of cell proliferation (GO:0008285) 3.263NOTCH1, DLL4, RBPJ
tube morphogenesis (GO:0035239) 4.353NOTCH1, DLL4, RBPJ
cardiac muscle tissue morphogenesis (GO:0055008) 5.83NOTCH1, DLL4, RBPJ
regulation of nucleic acid-templated transcription (GO:1903506) 1.553NOTCH1, DLL4, RBPJ
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.713NOTCH1, DLL4, RBPJ
regulation of cell differentiation (GO:0045595) 2.423NOTCH1, DLL4, RBPJ
negative regulation of transcription, DNA-templated (GO:0045892) 2.753NOTCH1, DLL4, RBPJ
negative regulation of RNA metabolic process (GO:0051253) 2.663NOTCH1, DLL4, RBPJ
regulation of RNA metabolic process (GO:0051252) 1.523NOTCH1, DLL4, RBPJ
developmental process (GO:0032502) 1.363NOTCH1, DLL4, RBPJ
ventricular cardiac muscle tissue morphogenesis (GO:0055010) 6.073NOTCH1, DLL4, RBPJ
negative regulation of cellular biosynthetic process (GO:0031327) 2.493NOTCH1, DLL4, RBPJ
regulation of cellular biosynthetic process (GO:0031326) 1.383NOTCH1, DLL4, RBPJ
negative regulation of cellular metabolic process (GO:0031324) 2.013NOTCH1, DLL4, RBPJ
regulation of cellular metabolic process (GO:0031323) 1.073NOTCH1, DLL4, RBPJ
angiogenesis (GO:0001525) 4.153NOTCH1, DLL4, RBPJ
pattern specification process (GO:0007389) 3.793NOTCH1, DLL4, RBPJ
artery morphogenesis (GO:0048844) 5.883NOTCH1, DLL4, RBPJ
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.463NOTCH1, DLL4, RBPJ
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.63NOTCH1, DLL4, RBPJ
regulation of macromolecule biosynthetic process (GO:0010556) 1.433NOTCH1, DLL4, RBPJ
tissue morphogenesis (GO:0048729) 3.873NOTCH1, DLL4, RBPJ
regulation of gene expression (GO:0010468) 1.373NOTCH1, DLL4, RBPJ
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.553NOTCH1, DLL4, RBPJ
morphogenesis of an epithelium (GO:0002009) 4.083NOTCH1, DLL4, RBPJ
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433NOTCH1, DLL4, RBPJ
single-organism developmental process (GO:0044767) 1.493NOTCH1, DLL4, RBPJ
regulation of nitrogen compound metabolic process (GO:0051171) 1.363NOTCH1, DLL4, RBPJ
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.473NOTCH1, DLL4, RBPJ
anatomical structure development (GO:0048856) 1.583NOTCH1, DLL4, RBPJ
regulation of multicellular organismal development (GO:2000026) 2.313NOTCH1, DLL4, RBPJ
negative regulation of cellular process (GO:0048523) 1.413NOTCH1, DLL4, RBPJ
positive regulation of cellular process (GO:0048522) 1.33NOTCH1, DLL4, RBPJ
protein localization (GO:0008104) 2.362NOTCH1, RBPJ
negative regulation of response to stimulus (GO:0048585) 2.522NOTCH1, DLL4
tissue remodeling (GO:0048771) 5.542DLL4, RBPJ
regulation of Wnt signaling pathway (GO:0030111) 3.982NOTCH1, RBPJ
cellular component organization (GO:0016043) 1.242NOTCH1, RBPJ
regulation of sprouting angiogenesis (GO:1903670) 6.332NOTCH1, DLL4
negative regulation of sprouting angiogenesis (GO:1903671) 7.332NOTCH1, DLL4
inner ear receptor cell fate commitment (GO:0060120) 8.632NOTCH1, RBPJ
organic substance biosynthetic process (GO:1901576) 1.342NOTCH1, RBPJ
regulation of BMP signaling pathway (GO:0030510) 5.362NOTCH1, RBPJ
pericardium morphogenesis (GO:0003344) 7.942NOTCH1, DLL4
organic cyclic compound metabolic process (GO:1901360) 1.262NOTCH1, RBPJ
RNA biosynthetic process (GO:0032774) 1.842NOTCH1, RBPJ
positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:0036003) 6.592NOTCH1, RBPJ
response to external biotic stimulus (GO:0043207) 3.132NOTCH1, RBPJ
endothelium development (GO:0003158) 7.242NOTCH1, RBPJ
response to growth factor (GO:0070848) 4.142NOTCH1, DLL4
regulation of cardiac muscle tissue growth (GO:0055021) 6.122NOTCH1, RBPJ
endothelial tube morphogenesis (GO:0061154) 7.332DLL4, RBPJ
animal organ development (GO:0048513) 2.532NOTCH1, RBPJ
positive regulation of molecular function (GO:0044093) 2.232ARHGAP31, DOCK6
epithelial cell differentiation (GO:0030855) 3.982NOTCH1, RBPJ
macromolecule localization (GO:0033036) 2.342NOTCH1, RBPJ
regulation of striated muscle tissue development (GO:0016202) 5.092NOTCH1, RBPJ
keratinocyte differentiation (GO:0030216) 5.372NOTCH1, RBPJ
negative regulation of blood vessel endothelial cell migration (GO:0043537) 6.552NOTCH1, DLL4
developmental process involved in reproduction (GO:0003006) 3.362NOTCH1, RBPJ
regulation of blood vessel endothelial cell migration (GO:0043535) 5.82NOTCH1, DLL4
lymphocyte activation (GO:0046649) 3.962DLL4, RBPJ
regionalization (GO:0003002) 4.242NOTCH1, RBPJ
response to biotic stimulus (GO:0009607) 3.092NOTCH1, RBPJ
regulation of development, heterochronic (GO:0040034) 7.242NOTCH1, RBPJ
positive regulation of BMP signaling pathway (GO:0030513) 6.262NOTCH1, RBPJ
response to organic substance (GO:0010033) 2.22NOTCH1, DLL4
heterocycle metabolic process (GO:0046483) 1.312NOTCH1, RBPJ
stem cell population maintenance (GO:0019827) 4.832NOTCH1, RBPJ
cardiac left ventricle morphogenesis (GO:0003214) 7.532NOTCH1, RBPJ
single organism reproductive process (GO:0044702) 2.732NOTCH1, RBPJ
endocardium morphogenesis (GO:0003160) 9.042NOTCH1, RBPJ
regulation of epithelial cell migration (GO:0010632) 4.622NOTCH1, DLL4
response to external stimulus (GO:0009605) 2.552NOTCH1, RBPJ
negative regulation of epithelial cell migration (GO:0010633) 5.762NOTCH1, DLL4
protein metabolic process (GO:0019538) 1.452EOGT, DLL4
blood vessel lumenization (GO:0072554) 9.042DLL4, RBPJ
regulation of timing of cell differentiation (GO:0048505) 7.242NOTCH1, RBPJ
cellular response to stress (GO:0033554) 2.512NOTCH1, RBPJ
aromatic compound biosynthetic process (GO:0019438) 1.72NOTCH1, RBPJ
cellular response to vascular endothelial growth factor stimulus (GO:0035924) 6.552NOTCH1, DLL4
regulation of canonical Wnt signaling pathway (GO:0060828) 4.262NOTCH1, RBPJ
negative regulation of cell communication (GO:0010648) 2.662NOTCH1, DLL4
positive regulation of GTPase activity (GO:0043547) 3.282ARHGAP31, DOCK6
positive regulation of striated muscle tissue development (GO:0045844) 5.692NOTCH1, RBPJ
positive regulation of biosynthetic process (GO:0009891) 2.292NOTCH1, RBPJ
negative regulation of ossification (GO:0030279) 5.482NOTCH1, RBPJ
leukocyte activation (GO:0045321) 3.762DLL4, RBPJ
regulation of vasculature development (GO:1901342) 4.262NOTCH1, DLL4
negative regulation of vasculature development (GO:1901343) 5.322NOTCH1, DLL4
positive regulation of cell differentiation (GO:0045597) 3.012NOTCH1, RBPJ
cell fate specification (GO:0001708) 5.572NOTCH1, RBPJ
intracellular signal transduction (GO:0035556) 2.392ARHGAP31, DOCK6
regulation of transcription from RNA polymerase II promoter in response to hypoxia (GO:0061418) 6.262NOTCH1, RBPJ
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia (GO:0061419) 8.342NOTCH1, RBPJ
nucleic acid-templated transcription (GO:0097659) 1.912NOTCH1, RBPJ
cellular protein metabolic process (GO:0044267) 1.632EOGT, DLL4
cell morphogenesis involved in differentiation (GO:0000904) 4.672NOTCH1, RBPJ
cell morphogenesis (GO:0000902) 4.352NOTCH1, RBPJ
positive regulation of hydrolase activity (GO:0051345) 2.912ARHGAP31, DOCK6
organic cyclic compound biosynthetic process (GO:1901362) 1.662NOTCH1, RBPJ
regulation of cell proliferation involved in heart morphogenesis (GO:2000136) 7.022NOTCH1, RBPJ
cardiac atrium morphogenesis (GO:0003209) 7.942NOTCH1, DLL4
inflammatory response to antigenic stimulus (GO:0002437) 6.512NOTCH1, RBPJ
negative regulation of signal transduction (GO:0009968) 2.752NOTCH1, DLL4
cellular component organization or biogenesis (GO:0071840) 1.222NOTCH1, RBPJ
transcription initiation from RNA polymerase II promoter (GO:0006367) 4.72NOTCH1, RBPJ
transcription from RNA polymerase II promoter (GO:0006366) 3.382NOTCH1, RBPJ
dorsal aorta morphogenesis (GO:0035912) 8.122DLL4, RBPJ
heterocycle biosynthetic process (GO:0018130) 1.72NOTCH1, RBPJ
regulation of muscle tissue development (GO:1901861) 5.072NOTCH1, RBPJ
positive regulation of muscle tissue development (GO:1901863) 5.672NOTCH1, RBPJ
transport (GO:0006810) 1.512NOTCH1, RBPJ
lymphocyte differentiation (GO:0030098) 4.492DLL4, RBPJ
nucleobase-containing compound metabolic process (GO:0006139) 1.352NOTCH1, RBPJ
protein secretion (GO:0009306) 4.972NOTCH1, RBPJ
regulation of cardiac muscle tissue development (GO:0055024) 5.862NOTCH1, RBPJ
positive regulation of cardiac muscle tissue development (GO:0055025) 6.332NOTCH1, RBPJ
tissue development (GO:0009888) 3.272NOTCH1, RBPJ
positive regulation of cardiac muscle tissue growth (GO:0055023) 6.592NOTCH1, RBPJ
defense response (GO:0006952) 2.782NOTCH1, RBPJ
maintenance of cell number (GO:0098727) 4.822NOTCH1, RBPJ
cell activation (GO:0001775) 3.472DLL4, RBPJ
epithelial cell fate commitment (GO:0072148) 7.652NOTCH1, RBPJ
immune response (GO:0006955) 2.862NOTCH1, RBPJ
nucleobase-containing compound biosynthetic process (GO:0034654) 1.722NOTCH1, RBPJ
regulation of ossification (GO:0030278) 4.532NOTCH1, RBPJ
establishment of localization (GO:0051234) 1.482NOTCH1, RBPJ
regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213) 7.432NOTCH1, RBPJ
leukocyte differentiation (GO:0002521) 4.132DLL4, RBPJ
regulation of hydrolase activity (GO:0051336) 2.532ARHGAP31, DOCK6
positive regulation of transcription of Notch receptor target (GO:0007221) 7.782NOTCH1, RBPJ
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592NOTCH1, RBPJ
endocardium development (GO:0003157) 8.342NOTCH1, RBPJ
response to stress (GO:0006950) 1.82NOTCH1, RBPJ
blood vessel remodeling (GO:0001974) 6.232DLL4, RBPJ
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392NOTCH1, RBPJ
regulation of nervous system development (GO:0051960) 3.12NOTCH1, DLL4
regulation of cell motility (GO:2000145) 3.162NOTCH1, DLL4
transcription, DNA-templated (GO:0006351) 1.912NOTCH1, RBPJ
DNA-templated transcription, initiation (GO:0006352) 4.492NOTCH1, RBPJ
negative regulation of cell motility (GO:2000146) 4.362NOTCH1, DLL4
aorta morphogenesis (GO:0035909) 6.842DLL4, RBPJ
positive regulation of multicellular organismal process (GO:0051240) 2.492NOTCH1, RBPJ
negative regulation of cell differentiation (GO:0045596) 3.332NOTCH1, RBPJ
positive regulation of developmental growth (GO:0048639) 4.672NOTCH1, RBPJ
regulation of developmental growth (GO:0048638) 4.042NOTCH1, RBPJ
inflammatory response (GO:0006954) 3.642NOTCH1, RBPJ
regulation of Notch signaling pathway (GO:0008593) 5.512NOTCH1, DLL4
regulation of muscle organ development (GO:0048634) 5.072NOTCH1, RBPJ
positive regulation of muscle organ development (GO:0048636) 5.692NOTCH1, RBPJ
negative regulation of signaling (GO:0023057) 2.652NOTCH1, DLL4
cellular nitrogen compound metabolic process (GO:0034641) 1.222NOTCH1, RBPJ
regulation of transcription from RNA polymerase II promoter in response to stress (GO:0043618) 5.62NOTCH1, RBPJ
cellular response to chemical stimulus (GO:0070887) 2.572NOTCH1, DLL4
regulation of cardiac muscle cell proliferation (GO:0060043) 6.332NOTCH1, RBPJ
regulation of GTPase activity (GO:0043087) 3.212ARHGAP31, DOCK6
positive regulation of catalytic activity (GO:0043085) 2.42ARHGAP31, DOCK6
response to endogenous stimulus (GO:0009719) 2.792NOTCH1, DLL4
regulation of neurogenesis (GO:0050767) 3.212NOTCH1, DLL4
regulation of cellular response to growth factor stimulus (GO:0090287) 4.292NOTCH1, RBPJ
regulation of intracellular signal transduction (GO:1902531) 2.312ARHGAP31, NOTCH1
regulation of cell migration involved in sprouting angiogenesis (GO:0090049) 6.782NOTCH1, DLL4
positive regulation of cardiac muscle cell proliferation (GO:0060045) 6.782NOTCH1, RBPJ
regulation of cell development (GO:0060284) 3.012NOTCH1, DLL4
positive regulation of Notch signaling pathway (GO:0045747) 6.232NOTCH1, DLL4
regulation of neural precursor cell proliferation (GO:2000177) 5.452NOTCH1, DLL4
positive regulation of neural precursor cell proliferation (GO:2000179) 6.092NOTCH1, DLL4
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562NOTCH1, RBPJ
RNA metabolic process (GO:0016070) 1.592NOTCH1, RBPJ
regulation of heart growth (GO:0060420) 5.972NOTCH1, RBPJ
positive regulation of heart growth (GO:0060421) 6.432NOTCH1, RBPJ
interleukin-4 secretion (GO:0072602) 8.342NOTCH1, RBPJ
establishment of protein localization (GO:0045184) 2.532NOTCH1, RBPJ
epithelium development (GO:0060429) 4.572NOTCH1, RBPJ
cellular aromatic compound metabolic process (GO:0006725) 1.32NOTCH1, RBPJ
negative regulation of locomotion (GO:0040013) 4.222NOTCH1, DLL4
biosynthetic process (GO:0009058) 1.322NOTCH1, RBPJ
regulation of striated muscle cell differentiation (GO:0051153) 5.262NOTCH1, RBPJ
cellular macromolecule biosynthetic process (GO:0034645) 1.662NOTCH1, RBPJ
regulation of locomotion (GO:0040012) 3.122NOTCH1, DLL4
positive regulation of transcription, DNA-templated (GO:0045893) 2.562NOTCH1, RBPJ
secretion (GO:0046903) 3.382NOTCH1, RBPJ
regulation of localization (GO:0032879) 1.942NOTCH1, DLL4
anterior/posterior pattern specification (GO:0009952) 4.712NOTCH1, RBPJ
negative regulation of developmental process (GO:0051093) 3.172NOTCH1, DLL4
regulation of epithelial cell proliferation (GO:0050678) 4.062NOTCH1, DLL4
positive regulation of developmental process (GO:0051094) 2.772NOTCH1, RBPJ
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation (GO:0003256) 7.782NOTCH1, RBPJ
positive regulation of RNA metabolic process (GO:0051254) 2.512NOTCH1, RBPJ
macromolecule biosynthetic process (GO:0009059) 1.612NOTCH1, RBPJ
epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198) 7.332NOTCH1, RBPJ
positive regulation of RNA biosynthetic process (GO:1902680) 2.542NOTCH1, RBPJ
nitrogen compound metabolic process (GO:0006807) 1.132NOTCH1, RBPJ
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.812NOTCH1, RBPJ
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus (GO:1901522) 6.432NOTCH1, RBPJ
gland development (GO:0048732) 4.152NOTCH1, RBPJ
negative regulation of angiogenesis (GO:0016525) 5.422NOTCH1, DLL4
cellular response to endogenous stimulus (GO:0071495) 3.332NOTCH1, DLL4
negative regulation of blood vessel morphogenesis (GO:2000181) 5.382NOTCH1, DLL4
positive regulation of growth (GO:0045927) 4.252NOTCH1, RBPJ
positive regulation of cellular biosynthetic process (GO:0031328) 2.32NOTCH1, RBPJ
positive regulation of cellular metabolic process (GO:0031325) 1.812NOTCH1, RBPJ
branching morphogenesis of an epithelial tube (GO:0048754) 4.932NOTCH1, DLL4
negative regulation of cell migration involved in sprouting angiogenesis (GO:0090051) 7.432NOTCH1, DLL4
nucleic acid metabolic process (GO:0090304) 1.462NOTCH1, RBPJ
molting cycle process (GO:0022404) 5.542NOTCH1, RBPJ
hair cycle process (GO:0022405) 5.542NOTCH1, RBPJ
morphogenesis of a branching structure (GO:0001763) 4.712NOTCH1, DLL4
regulation of muscle cell differentiation (GO:0051147) 4.682NOTCH1, RBPJ
multicellular organism development (GO:0007275) 2.542NOTCH1, DLL4
cytokine secretion (GO:0050663) 6.072NOTCH1, RBPJ
regulation of growth (GO:0040008) 3.262NOTCH1, RBPJ
secretion by cell (GO:0032940) 3.592NOTCH1, RBPJ
regulation of angiogenesis (GO:0045765) 4.362NOTCH1, DLL4
humoral immune response (GO:0006959) 4.592NOTCH1, RBPJ
cellular component morphogenesis (GO:0032989) 3.52NOTCH1, RBPJ
cellular response to organic substance (GO:0071310) 2.782NOTCH1, DLL4
organic substance transport (GO:0071702) 2.152NOTCH1, RBPJ
embryonic morphogenesis (GO:0048598) 3.722NOTCH1, DLL4
negative regulation of cell migration (GO:0030336) 4.412NOTCH1, DLL4
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092) 4.392NOTCH1, RBPJ
regulation of cell migration (GO:0030334) 3.232NOTCH1, DLL4
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352NOTCH1, RBPJ
neuron differentiation (GO:0030182) 4.172NOTCH1, RBPJ
morphogenesis of a branching epithelium (GO:0061138) 4.772NOTCH1, DLL4
regulation of organ growth (GO:0046620) 5.412NOTCH1, RBPJ
positive regulation of organ growth (GO:0046622) 6.092NOTCH1, RBPJ
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090100) 5.122NOTCH1, RBPJ
reproductive process (GO:0022414) 2.552NOTCH1, RBPJ
single-organism transport (GO:0044765) 2.182NOTCH1, RBPJ
cellular response to growth factor stimulus (GO:0071363) 4.272NOTCH1, DLL4
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292NOTCH1, RBPJ
response to chemical (GO:0042221) 1.982NOTCH1, DLL4
small GTPase mediated signal transduction (GO:0007264) 3.852ARHGAP31, DOCK6
regulation of heart morphogenesis (GO:2000826) 6.42NOTCH1, RBPJ
localization (GO:0051179) 1.42NOTCH1, RBPJ
single-organism localization (GO:1902578) 2.092NOTCH1, RBPJ
regulation of DNA-templated transcription in response to stress (GO:0043620) 5.522NOTCH1, RBPJ
heart development (GO:0007507) 4.242NOTCH1, RBPJ
negative regulation of cellular component movement (GO:0051271) 4.222NOTCH1, DLL4
regulation of cellular component movement (GO:0051270) 3.082NOTCH1, DLL4
regulation of endothelial cell migration (GO:0010594) 4.992NOTCH1, DLL4
negative regulation of endothelial cell migration (GO:0010596) 6.072NOTCH1, DLL4
epidermal cell differentiation (GO:0009913) 5.132NOTCH1, RBPJ
auditory receptor cell fate commitment (GO:0009912) 8.632NOTCH1, RBPJ
morphogenesis of an epithelial sheet (GO:0002011) 6.92NOTCH1, DLL4
epithelial to mesenchymal transition (GO:0001837) 5.762NOTCH1, RBPJ
cardiac epithelial to mesenchymal transition (GO:0060317) 6.552NOTCH1, RBPJ
regulation of organ morphogenesis (GO:2000027) 4.222NOTCH1, RBPJ
protein transport (GO:0015031) 2.622NOTCH1, RBPJ
cellular biosynthetic process (GO:0044249) 1.372NOTCH1, RBPJ

NET-GE enrichment

Term New enriched termICP valueGenes
ventricular cardiac muscle tissue morphogenesis (GO:0055010) -6.070.006NOTCH1, DLL4, RBPJ
negative regulation of ossification (GO:0030279) -5.480.024NOTCH1, RBPJ
regulation of cardiac muscle cell proliferation (GO:0060043) -6.330.027NOTCH1, RBPJ
blood vessel lumenization (GO:0072554) -9.040.0DLL4, RBPJ
positive regulation of cardiac muscle cell proliferation (GO:0060045) -6.780.013NOTCH1, RBPJ
Notch receptor processing (GO:0007220) NEW6.90.05NOTCH1, DLL4
cell fate commitment (GO:0045165) -4.720.005NOTCH1, DLL4, RBPJ
heart trabecula morphogenesis (GO:0061384) -7.090.0NOTCH1, DLL4, RBPJ
angiogenesis (GO:0001525) -4.150.026NOTCH1, DLL4, RBPJ
pericardium morphogenesis (GO:0003344) -7.940.0NOTCH1, DLL4
ventricular trabecula myocardium morphogenesis (GO:0003222) -7.330.0NOTCH1, DLL4, RBPJ
trabecula morphogenesis (GO:0061383) -6.960.0NOTCH1, DLL4, RBPJ
cytokine secretion (GO:0050663) -6.070.024NOTCH1, RBPJ
morphogenesis of an epithelium (GO:0002009) -4.080.049NOTCH1, DLL4, RBPJ
cardiac chamber morphogenesis (GO:0003206) -6.360.0NOTCH1, DLL4, RBPJ
penetration of zona pellucida (GO:0007341) NEW7.940.006NOTCH1, RBPJ
morphogenesis of an endothelium (GO:0003159) -7.240.0NOTCH1, DLL4, RBPJ
artery morphogenesis (GO:0048844) -5.880.018NOTCH1, DLL4, RBPJ
cardiac atrium morphogenesis (GO:0003209) -7.940.004NOTCH1, DLL4
cardiac ventricle morphogenesis (GO:0003208) -6.550.001NOTCH1, DLL4, RBPJ
inflammatory response to antigenic stimulus (GO:0002437) -6.510.014NOTCH1, RBPJ
endothelial tube morphogenesis (GO:0061154) -7.330.0NOTCH1, DLL4, RBPJ
negative regulation of Notch signaling pathway (GO:0045746) NEW6.360.001NOTCH1, DLL4, RBPJ
blood vessel endothelial cell differentiation (GO:0060837) NEW8.120.004NOTCH1, RBPJ
blood vessel morphogenesis (GO:0048514) -5.320.001NOTCH1, DLL4, RBPJ
epithelial tube morphogenesis (GO:0060562) -5.120.001NOTCH1, DLL4, RBPJ
cell surface receptor signaling pathway involved in heart development (GO:0061311) -6.960.0NOTCH1, DLL4, RBPJ
endothelial cell fate commitment (GO:0060839) NEW9.040.001NOTCH1, RBPJ
positive regulation of neural precursor cell proliferation (GO:2000179) -6.090.008NOTCH1, DLL4, RBPJ
dorsal aorta morphogenesis (GO:0035912) -8.120.001DLL4, RBPJ
Notch signaling involved in heart development (GO:0061314) -7.530.0NOTCH1, DLL4, RBPJ
Notch signaling pathway (GO:0007219) -4.990.004NOTCH1, DLL4, RBPJ
regulation of heart growth (GO:0060420) -5.970.049NOTCH1, RBPJ
tube morphogenesis (GO:0035239) -4.350.002NOTCH1, DLL4, RBPJ
neuron fate commitment (GO:0048663) -6.120.0NOTCH1, DLL4, RBPJ
cardiac muscle tissue morphogenesis (GO:0055008) -5.80.018NOTCH1, DLL4, RBPJ
positive regulation of transcription of Notch receptor target (GO:0007221) -7.780.001NOTCH1, RBPJ
regulation of cardiac muscle tissue growth (GO:0055021) -6.120.038NOTCH1, RBPJ
negative regulation of blood vessel endothelial cell migration (GO:0043537) -6.550.01NOTCH1, DLL4
inner ear receptor cell fate commitment (GO:0060120) -8.630.0NOTCH1, RBPJ
epithelial cell fate commitment (GO:0072148) -7.650.039NOTCH1, RBPJ
interleukin-4 secretion (GO:0072602) -8.340.001NOTCH1, RBPJ
positive regulation of BMP signaling pathway (GO:0030513) -6.260.02NOTCH1, RBPJ
regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213) -7.430.036NOTCH1, RBPJ
renal interstitial fibroblast development (GO:0072141) NEW9.040.008NOTCH1, DLL4
cardiac left ventricle morphogenesis (GO:0003214) -7.530.036NOTCH1, RBPJ
amacrine cell differentiation (GO:0035881) NEW8.120.015DLL4, RBPJ
endocardium morphogenesis (GO:0003160) -9.040.0NOTCH1, RBPJ
epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198) -7.330.002NOTCH1, RBPJ
negative regulation of epithelial cell migration (GO:0010633) -5.760.047NOTCH1, DLL4
notochord formation (GO:0014028) NEW8.340.003NOTCH1, RBPJ
negative regulation of endothelial cell migration (GO:0010596) -6.070.025NOTCH1, DLL4
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation (GO:0003256) -7.780.001NOTCH1, RBPJ
negative regulation of cell migration involved in sprouting angiogenesis (GO:0090051) -7.430.001NOTCH1, DLL4
morphogenesis of an epithelial sheet (GO:0002011) -6.90.008NOTCH1, DLL4
epithelial to mesenchymal transition (GO:0001837) -5.760.01NOTCH1, DLL4, RBPJ
blood vessel remodeling (GO:0001974) -6.230.004NOTCH1, DLL4, RBPJ
pulmonary valve morphogenesis (GO:0003184) NEW7.780.011NOTCH1, RBPJ
cardiac epithelial to mesenchymal transition (GO:0060317) -6.550.009NOTCH1, DLL4, RBPJ
auditory receptor cell fate commitment (GO:0009912) -8.630.0NOTCH1, RBPJ
aorta morphogenesis (GO:0035909) -6.840.008NOTCH1, DLL4, RBPJ
regulation of cell migration involved in sprouting angiogenesis (GO:0090049) -6.780.006NOTCH1, DLL4
cellular response to vascular endothelial growth factor stimulus (GO:0035924) -6.550.018NOTCH1, DLL4
muscle tissue morphogenesis (GO:0060415) -5.620.024NOTCH1, DLL4, RBPJ
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.116NOTCH1, EOGT, ARHGAP31, RBPJ, DOCK6, DLL4
intracellular part (GO:0044424) 0.285NOTCH1, ARHGAP31, DOCK6, RBPJ, EOGT
cytoplasmic part (GO:0044444) 0.824NOTCH1, ARHGAP31, DOCK6, EOGT
cytoplasm (GO:0005737) 1.013DOCK6, NOTCH1, RBPJ
intracellular membrane-bounded organelle (GO:0043231) 0.63NOTCH1, EOGT, RBPJ
cytosol (GO:0005829) 1.683NOTCH1, ARHGAP31, DOCK6
intracellular organelle part (GO:0044446) 0.813NOTCH1, EOGT, RBPJ
intracellular organelle (GO:0043229) 0.513NOTCH1, EOGT, RBPJ
membrane-bounded organelle (GO:0043227) 0.473NOTCH1, EOGT, RBPJ
organelle (GO:0043226) 0.43NOTCH1, EOGT, RBPJ
organelle part (GO:0044422) 0.793NOTCH1, EOGT, RBPJ
protein complex (GO:0043234) 1.512NOTCH1, RBPJ
anchoring junction (GO:0070161) 3.612ARHGAP31, NOTCH1
macromolecular complex (GO:0032991) 1.352NOTCH1, RBPJ
endoplasmic reticulum (GO:0005783) 2.562NOTCH1, EOGT
integral component of membrane (GO:0016021) 1.142NOTCH1, DLL4
membrane (GO:0016020) 0.682NOTCH1, DLL4
intracellular (GO:0005622) 2.372ARHGAP31, DOCK6
nucleoplasm (GO:0005654) 1.892NOTCH1, RBPJ
endoplasmic reticulum part (GO:0044432) 2.732NOTCH1, EOGT
nuclear part (GO:0044428) 1.552NOTCH1, RBPJ
intrinsic component of membrane (GO:0031224) 1.132NOTCH1, DLL4
plasma membrane (GO:0005886) 1.392NOTCH1, DLL4
membrane part (GO:0044425) 0.952NOTCH1, DLL4
MAML1-RBP-Jkappa- ICN1 complex (GO:0002193) 8.72NOTCH1, RBPJ
nucleus (GO:0005634) 1.072NOTCH1, RBPJ
cell junction (GO:0030054) 2.752ARHGAP31, NOTCH1
adherens junction (GO:0005912) 3.662ARHGAP31, NOTCH1

NET-GE enrichment

Term New enriched termICP valueGenes
MAML1-RBP-Jkappa- ICN1 complex (GO:0002193) -8.70.0NOTCH1, RBPJ
cell-substrate adherens junction (GO:0005924) NEW3.830.012NOTCH1, ARHGAP31, DLL4, RBPJ
anchoring junction (GO:0070161) -3.610.027NOTCH1, ARHGAP31, DLL4, RBPJ
adherens junction (GO:0005912) -3.660.023NOTCH1, ARHGAP31, DLL4, RBPJ
cell-substrate junction (GO:0030055) NEW3.820.013NOTCH1, ARHGAP31, DLL4, RBPJ