Disease table of SQUAMOUS CELL CARCINOMA, HEAD AND NECK OMIM ID: 275355

Gene-disease associations table

GeneAssociated with SQUAMOUS CELL CARCINOMA, HEAD AND NECK inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
PTENClinVar, OMIM, HUMSAVARHGNC link10q23.3110276950, 608089, 275355, 176807, PS155600, PS137800, 605309, 607174, 153480, PS158350
TNFRSF10BOMIMHGNC link8p21.31275355
EGFRClinVarHGNC link7p11.23275355, 211980, PS614328
ING1ClinVar, OMIM, HUMSAVARHGNC link13q341275355
ING3HUMSAVARHGNC link7q31.311275355

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
72EGFR, ING3
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
ING1YES7CDKN1A, AFP, DGCR8, BAX, TP53, CASP3, PCNA0
YY1NO74FCER1A, CFTR, EGFR, GDAP1, POSTN, TP53, ATP2C1, IFNG, ADORA2A, KIR3DL1, TOP3A, HBE1, LDLR, SERPINE1, LRIG2, HSPA5, GBP1, HLA-DRA, APC, HAS2, CCL13, SNRPN, FMO3, TFRC, CTCF, FAS, TF, CXCR4, FCGR3B, DNAJB4, HSD3B2, ERBB2, SURF1, TDO2, IVL, BRCA1, DEK, COX7C, CETP, ERCC5, NOS2, BDKRB1, SLC26A3, EPAS1, ACTC1, ZNF175, BAP1, TNFRSF10B, HOXB7, NF1, OPRM1, PCNA, PARP1, PRDM2, VWF, TP73, CCR5, CBX5, SURF2, IL4, NR3C1, PDIA6, CYP3A5, CREBBP, HCFC1, IL5, DBH, RB1, FDPS, FCGR2B, LSS, MYC, HOXB13, COL1A22TNFRSF10B, EGFR
STAT3NO129IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP123TNFRSF10B, EGFR, PTEN
TFAP2ANO69SLC19A1, POLD2, L1CAM, MCAM, GALNT3, CRYAB, KISS1, CGB, EGFR, HTT, GAST, COL1A1, NME3, PTGS2, SPRY2, ACHE, MUC4, DBH, FOXA1, GUSB, DCBLD2, IGFBP5, CFTR, HSD17B1, ERBB2, ETS1, CD82, CYP11A1, PVR, ADM, KRT5, KIT, CCNB1, HGF, F2R, ECM1, APP, MPG, CRABP2, CDH1, PTEN, KLF12, VEGFA, GPX4, SULT1E1, CGA, LNPEP, TIMP2, MMP9, HOXA4, TAF7, NR3C1, BCL2, PLAUR, TH, ADRA2B, MMP2, CDKN1A, FAS, ADRA1A, IMPDH2, SNAP91, PRKCA, HMOX1, BACE1, CRX, BRS3, HIP1, CSH12EGFR, PTEN
EGR1NO90ATF3, PTEN, IFNG, EGFR, PDGFB, RAG2, SLC9A3, IMPDH2, SYN1, TP53, FCER2, IL2, SYN2, FAP, CHGA, GGPS1, PSEN2, SOX18, AR, GDF15, SLC4A2, LMTK2, TFPI2, MYB, TMPO, POR, FGF2, PTP4A1, PTGS2, CCND2, IL2RB, TNF, PCSK2, ALOX5, HSD11B2, ACHE, TNFSF10, TOE1, DMRT1, LHB, F3, ABCB1, STMN1, PLAUR, BCAR1, TP73, HIF1A, TGFBR2, ID3, AKR1B1, RBL2, TBXA2R, HYAL1, CACNA1H, LTB, CDK5R1, CD28, TCF4, CCND1, LDLR, MMP14, KLK3, GDNF, EAPP, PTGES, STIM1, SPRY1, VEGFA, EP300, CXCL8, NAB2, IGF2, FLT1, PDGFC, HPSE, WNT4, FN1, PLAU, ACE, UBE2S, FAS, CYP2B6, CDKN1A, SOD1, FASLG, NFKB1, IL3, IL6, LAT, PPARG2EGFR, PTEN
NFKB1NO306NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC63TNFRSF10B, EGFR, PTEN
RELANO302NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC63TNFRSF10B, EGFR, PTEN
MTA1NO20EPHA2, NOS2, MMP9, EGFR, MNAT1, MTA3, SNAI1, SMAD7, BCL2L1, CDH1, MYC, CDKN1A, SNAI2, PTEN, ITGB3BP, ESR1, CDKN2A, SUMO2, BRCA1, TFF12EGFR, PTEN
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC13TNFRSF10B, EGFR, PTEN
PPARGNO69BCL2L1, EGFR, PLIN2, TNFRSF11B, CPT1B, DEFB103A, NOTCH4, VLDLR, SAT1, TP53, DBI, CAV1, CIDEA, PDK2, SERPINE1, CFLAR, ATP2A2, STAT6, ICAM1, TXNIP, FABP4, PTGS2, JAG1, CCNE1, GDF15, CEBPA, KLF5, GK, APOBR, ERO1L, RETN, CD83, TG, AGER, CAT, CSF1, POU2F1, BCL2, REN, UGT1A9, CDKN1A, CLDN2, ERP44, RARB, ANGPTL4, ADIPOQ, SOCS7, PTEN, BAD, SLC2A4, FGF1, SLC9A1, CD36, ABCG2, MMP1, BRS3, NR1H3, TSHR, LIPE, SLC5A5, ACAT1, MMP9, APOB, HMOX1, CIITA, MYC, CCND1, KLF4, FASLG2EGFR, PTEN
ARNO83UGT2B15, PTPN1, CDH11, AKR1C3, USP26, FOLH1, CCR2, CDK20, CDK6, PNRC1, ARG1, XIAP, VIM, ARG2, EGFR, CFLAR, ETV1, BSG, IGF1R, MUC1, WEE1, PTGS2, NKX3-1, AKT1, NRAS, CDH1, EP300, KLF5, ACTA1, CLK3, FN1, TNF, PRL, ERBB2, ERBB3, CRISP3, CTNNB1, PTEN, CRISP1, SERPINB5, TSC2, NAT1, CDKN1A, GREB1, SEPT7, IFI16, PIGR, KLK3, PC, STIM1, SRD5A3, TCF7L2, JUN, TMPRSS2, RELA, TJP1, BTG1, VEGFA, NFKB1, HMMR, FKBP5, KLK4, CRH, CDH2, BTG2, TGFA, SESN1, CDC6, TH, ALDH1A3, KISS1, KISS1R, PEBP1, KLK2, ATAD2, HMOX1, TSC1, WNT7B, PEG10, TRPS1, CCND1, PIP, FOXA12EGFR, PTEN
TP53NO159ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING14ING1, TNFRSF10B, EGFR, PTEN
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
PTENYES15SP1, STAT3, EGR1, TCF4, NFKB1, MTA1, AR, TP53, HES1, TFAP2A, RELA, RBPJ, MXD1, PPARG, SRF0
TNFRSF10BYES16SP1, ATM, STAT3, ELK1, GLI1, YY1, DDIT3, TP53, MYC, DNMT1, GLI2, RELA, HDAC9, NFKB1, ATF4, SIRT10
EGFRYES30AR, BCL3, WWP1, NR3C2, TFAP2A, PGR, NFKB2, SP1, EGR1, PML, HDAC3, MTA1, BRCA1, WT1, VDR, HOXB7, JUN, TP53, RELA, LRRFIP1, NFKB1, STAT1, STAT3, YY1, YBX1, ESR1, JUNB, PPARG, CREBBP, TSG1010
ING1YES2RUNX3, TP530
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
PTENTNFRSF10BNo3NDFIP1, CBL, CASP8
PTENEGFRNo57TXN, HSPA1A, USP8, STIP1, PRDX1, AR, SSR4, IRS4, CAV1, HSP90AB1, TUBB3, RPL38, MYO1B, STUB1, POLDIP2, TUBB4B, TUBB2A, CFL1, PDGFRB, LIMA1, ATP5C1, PTK2, DNAJA1, NDFIP1, CRKL, CTNNB1, HBA1, HSPA2, ESR1, CALM1, FRK, LGALS1, ACACA, PC, HSP90AA1, UBC, JUP, CDH1, AKT1, PDGFRA, RPL23, CSNK2A1, YES1, MYO1C, HSPA8, PELO, ARF4, PTK2B, MYO1D, ATP5A1, TUBB, CBL, NEDD4, S100A9, NDFIP2, RPS15A, AKAP12
PTENING1No6KAT2B, USP7, ELAVL1, TP53, ESR1, UBC
PTENING3No1ELAVL1
TNFRSF10BEGFRYes12TNFRSF1A, ITCH, LSR, MAPK8, CBL, BMPR1A, RIPK1, NDFIP1, EGFR, TRAF2, TIMM50, EZR
EGFRING1No8PCNA, KPNB1, YWHAB, ESR1, UBC, YWHAQ, SFN, YWHAZ
EGFRING3No4FBXO25, HSPA5, SNRPA1, APP
ING1ING3No7ACTL6A, MRGBP, HHT1, ELAVL1, TRRAP, DMAP1, HHT2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
PTENTNFRSF10BNo-7MAPK8, TP53, IKBKB, UBC, TGM2, HDAC9, CHUK
PTENEGFRYesactivation, ptmod48AR, PTGER1, PRDX1, TP53, SRC, CAV1, CREB1, PIK3CA, PIK3CG, PDGFB, VEGFA, INS, EGR1, PIK3R5, NCOA3, PTK2, IL8, CSF1, SOS1, ID1, MAPK14, BIRC5, CDH1, JUN, GRB2, PIK3R3, PXN, PDGFRA, SHC1, VMP1, PIK3C2B, NOTCH1, PDGFRB, IGF1R, PIK3CB, MTOR, CBL, SPRY2, PIK3R1, NEDD4, ESR1, ITGB1, UBC, PIK3CD, LEP, CCND1, HIF1A, SLC9A3R1
PTENING1No-6KAT2B, BAX, TP53, SMARCA4, UBC, HDAC9
PTENING3No-4HDAC9, MCRS1, CCND1, MTOR
TNFRSF10BEGFRNo-5UBC, RHOA, NFKB1, TRAF2, TP53
TNFRSF10BING1No-3UBC, HDAC9, TP53
TNFRSF10BING3No-1HDAC9
EGFRING1No-3UBC, TP53, PCNA
EGFRING3No-3CCND1, MTOR, PCNA
ING1ING3No-9DMAP1, EPC1, MORF4L1, HDAC1, MRGBP, EPC2, PCNA, HDAC9, ACTL6A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
ING1ING3No-1ACTL6A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Melanomahsa052186.562EGFR, PTEN
FoxO signaling pathwayhsa040685.632EGFR, PTEN
Endometrial cancerhsa052136.812EGFR, PTEN
MicroRNAs in cancerhsa052065.382EGFR, PTEN
Pathways in cancerhsa052003.982EGFR, PTEN
Gliomahsa052146.662EGFR, PTEN
Prostate cancerhsa052156.112EGFR, PTEN
Central carbon metabolism in cancerhsa052306.72EGFR, PTEN
Focal adhesionhsa045104.922EGFR, PTEN
p53 signaling pathwayhsa041156.562TNFRSF10B, PTEN
Cytokine-cytokine receptor interactionhsa040604.672TNFRSF10B, EGFR
PI3K-Akt signaling pathwayhsa041514.212EGFR, PTEN

NET-GE enrichment

Term New enriched termICP valueGenes
Melanoma (hsa05218) -6.560.021EGFR, PTEN
Endometrial cancer (hsa05213) -6.810.015EGFR, PTEN
Glioma (hsa05214) -6.660.018EGFR, PTEN
Prostate cancer (hsa05215) -6.110.039EGFR, PTEN
Central carbon metabolism in cancer (hsa05230) -6.70.017EGFR, PTEN
p53 signaling pathway (hsa04115) -6.560.021TNFRSF10B, PTEN
REACTOME pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signal TransductionR-HSA-1625821.783TNFRSF10B, PTEN, EGFR
PI3K/AKT activationR-HSA-1982036.322EGFR, PTEN
Immune SystemR-HSA-1682562.372EGFR, PTEN
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.622EGFR, PTEN
Downstream signal transductionR-HSA-1867634.652EGFR, PTEN
GAB1 signalosomeR-HSA-1802926.312EGFR, PTEN
Signaling by ERBB4R-HSA-12363944.72EGFR, PTEN
Adaptive Immune SystemR-HSA-12802183.192EGFR, PTEN
DiseaseR-HSA-16436853.332EGFR, PTEN
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.952EGFR, PTEN
Downstream signaling of activated FGFR1R-HSA-56546874.712EGFR, PTEN
Signalling by NGFR-HSA-1665204.232EGFR, PTEN
PI-3K cascade:FGFR4R-HSA-56547206.372EGFR, PTEN
PI-3K cascade:FGFR1R-HSA-56546896.372EGFR, PTEN
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.592EGFR, PTEN
Downstream signaling of activated FGFR3R-HSA-56547084.712EGFR, PTEN
Signaling by FGFR4R-HSA-56547434.692EGFR, PTEN
Signaling by FGFR3R-HSA-56547414.692EGFR, PTEN
Signaling by FGFRR-HSA-1902364.672EGFR, PTEN
PI3K/AKT Signaling in CancerR-HSA-22195286.562EGFR, PTEN
Diseases of signal transductionR-HSA-56632024.892EGFR, PTEN
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.032EGFR, PTEN
Innate Immune SystemR-HSA-1682493.172EGFR, PTEN
Signaling by SCF-KITR-HSA-14335574.732EGFR, PTEN
Signaling by PDGFR-HSA-1867974.532EGFR, PTEN
PI3K events in ERBB2 signalingR-HSA-19636426.372EGFR, PTEN
PI-3K cascade:FGFR2R-HSA-56546956.372EGFR, PTEN
Downstream signaling of activated FGFR2R-HSA-56546964.712EGFR, PTEN
Signaling by EGFRR-HSA-1779294.592EGFR, PTEN
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.512EGFR, PTEN
PIP3 activates AKT signalingR-HSA-12576046.372EGFR, PTEN
Signaling by FGFR2R-HSA-56547384.682EGFR, PTEN
Signaling by FGFR1R-HSA-56547364.692EGFR, PTEN
PI3K events in ERBB4 signalingR-HSA-12503426.372EGFR, PTEN
PI-3K cascade:FGFR3R-HSA-56547106.372EGFR, PTEN
DAP12 interactionsR-HSA-21721274.562EGFR, PTEN
Downstream signaling of activated FGFR4R-HSA-56547164.712EGFR, PTEN
Signaling by ERBB2R-HSA-12279864.662EGFR, PTEN
DAP12 signalingR-HSA-24244914.642EGFR, PTEN
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.185ING1, TNFRSF10B, EGFR, PTEN, ING3
protein binding (GO:0005515) 0.465ING1, TNFRSF10B, EGFR, PTEN, ING3
catalytic activity (GO:0003824) 1.053ING3, EGFR, PTEN
ion binding (GO:0043167) 1.363ING3, ING1, PTEN
metal ion binding (GO:0046872) 1.413ING3, ING1, PTEN
cation binding (GO:0043169) 1.43ING3, ING1, PTEN
histone binding (GO:0042393) 4.722ING3, ING1
methylated histone binding (GO:0035064) 5.812ING3, ING1
transition metal ion binding (GO:0046914) 2.482ING3, ING1
transmembrane signaling receptor activity (GO:0004888) 2.572TNFRSF10B, EGFR
enzyme binding (GO:0019899) 2.272EGFR, PTEN
molecular transducer activity (GO:0060089) 2.322TNFRSF10B, EGFR
transferase activity (GO:0016740) 1.952ING3, EGFR
identical protein binding (GO:0042802) 2.632EGFR, PTEN
macromolecular complex binding (GO:0044877) 2.612EGFR, PTEN
zinc ion binding (GO:0008270) 2.662ING3, ING1
signal transducer activity (GO:0004871) 2.282TNFRSF10B, EGFR
protein complex binding (GO:0032403) 3.092EGFR, PTEN
signaling receptor activity (GO:0038023) 2.492TNFRSF10B, EGFR
transmembrane receptor activity (GO:0099600) 2.532TNFRSF10B, EGFR
receptor activity (GO:0004872) 2.322TNFRSF10B, EGFR

NET-GE enrichment

Term New enriched termICP valueGenes
lipoprotein particle binding (GO:0071813) NEW6.560.035EGFR, PTEN
methylated histone binding (GO:0035064) -5.810.007ING3, ING1
protein-lipid complex binding (GO:0071814) NEW6.560.035EGFR, PTEN
hyaluronic acid binding (GO:0005540) NEW6.60.015EGFR, PTEN
transcription factor binding (GO:0008134) NEW3.460.044PTEN, TNFRSF10B, ING1, EGFR
low-density lipoprotein particle binding (GO:0030169) NEW7.030.019EGFR, PTEN
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of primary metabolic process (GO:0080090) 1.085ING1, TNFRSF10B, EGFR, PTEN, ING3
regulation of metabolic process (GO:0019222) 1.025ING1, TNFRSF10B, EGFR, PTEN, ING3
regulation of macromolecule metabolic process (GO:0060255) 1.085ING1, PTEN, TNFRSF10B, EGFR, ING3
cellular process (GO:0009987) 0.265ING1, TNFRSF10B, EGFR, PTEN, ING3
regulation of cellular metabolic process (GO:0031323) 1.075ING1, TNFRSF10B, EGFR, PTEN, ING3
regulation of cellular process (GO:0050794) 0.55ING1, TNFRSF10B, EGFR, PTEN, ING3
biological regulation (GO:0065007) 0.395ING1, TNFRSF10B, EGFR, PTEN, ING3
positive regulation of biological process (GO:0048518) 1.25ING1, TNFRSF10B, EGFR, PTEN, ING3
regulation of cell death (GO:0010941) 2.435ING1, TNFRSF10B, EGFR, PTEN, ING3
regulation of biological process (GO:0050789) 0.455ING1, TNFRSF10B, EGFR, PTEN, ING3
positive regulation of cellular process (GO:0048522) 1.35ING1, TNFRSF10B, EGFR, PTEN, ING3
positive regulation of metabolic process (GO:0009893) 1.744ING1, TNFRSF10B, EGFR, PTEN
regulation of cellular biosynthetic process (GO:0031326) 1.384ING1, EGFR, PTEN, ING3
positive regulation of cellular metabolic process (GO:0031325) 1.814ING1, TNFRSF10B, EGFR, PTEN
regulation of apoptotic process (GO:0042981) 2.54ING3, TNFRSF10B, EGFR, PTEN
cellular component organization or biogenesis (GO:0071840) 1.224ING1, EGFR, PTEN, ING3
positive regulation of macromolecule metabolic process (GO:0010604) 1.814ING1, TNFRSF10B, EGFR, PTEN
regulation of growth (GO:0040008) 3.264ING1, EGFR, PTEN, ING3
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.464ING1, EGFR, PTEN, ING3
cellular component organization (GO:0016043) 1.244ING1, EGFR, PTEN, ING3
regulation of programmed cell death (GO:0043067) 2.494ING3, TNFRSF10B, EGFR, PTEN
single-organism process (GO:0044699) 0.484PTEN, TNFRSF10B, ING1, EGFR
negative regulation of biological process (GO:0048519) 1.334PTEN, TNFRSF10B, ING1, EGFR
regulation of gene expression (GO:0010468) 1.374ING1, EGFR, PTEN, ING3
regulation of cell proliferation (GO:0042127) 2.414PTEN, TNFRSF10B, ING1, EGFR
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.434ING1, EGFR, PTEN, ING3
regulation of biosynthetic process (GO:0009889) 1.374ING1, EGFR, PTEN, ING3
regulation of nucleic acid-templated transcription (GO:1903506) 1.554ING1, EGFR, PTEN, ING3
single-organism cellular process (GO:0044763) 0.654ING1, TNFRSF10B, EGFR, PTEN
regulation of nitrogen compound metabolic process (GO:0051171) 1.364ING1, EGFR, PTEN, ING3
regulation of RNA biosynthetic process (GO:2001141) 1.554ING1, EGFR, PTEN, ING3
regulation of RNA metabolic process (GO:0051252) 1.524ING1, EGFR, PTEN, ING3
regulation of transcription, DNA-templated (GO:0006355) 1.564ING1, EGFR, PTEN, ING3
regulation of macromolecule biosynthetic process (GO:0010556) 1.434ING1, EGFR, PTEN, ING3
negative regulation of cellular process (GO:0048523) 1.414ING1, TNFRSF10B, EGFR, PTEN
positive regulation of protein modification process (GO:0031401) 2.73TNFRSF10B, EGFR, PTEN
regulation of phosphate metabolic process (GO:0019220) 2.353TNFRSF10B, PTEN, EGFR
cellular metabolic process (GO:0044237) 0.693ING3, EGFR, PTEN
negative regulation of response to stimulus (GO:0048585) 2.523TNFRSF10B, PTEN, EGFR
positive regulation of response to stimulus (GO:0048584) 2.183TNFRSF10B, EGFR, PTEN
regulation of response to stimulus (GO:0048583) 1.543TNFRSF10B, PTEN, EGFR
regulation of cellular component organization (GO:0051128) 2.013ING1, EGFR, PTEN
positive regulation of signaling (GO:0023056) 2.413TNFRSF10B, PTEN, EGFR
negative regulation of signaling (GO:0023057) 2.653TNFRSF10B, PTEN, EGFR
multicellular organismal process (GO:0032501) 1.453TNFRSF10B, EGFR, PTEN
regulation of phosphorus metabolic process (GO:0051174) 2.353TNFRSF10B, PTEN, EGFR
signal transduction (GO:0007165) 1.283TNFRSF10B, PTEN, EGFR
cell surface receptor signaling pathway (GO:0007166) 2.093TNFRSF10B, EGFR, PTEN
positive regulation of intracellular signal transduction (GO:1902533) 2.953TNFRSF10B, EGFR, PTEN
positive regulation of cell death (GO:0010942) 3.323TNFRSF10B, ING3, PTEN
intracellular signal transduction (GO:0035556) 2.393TNFRSF10B, EGFR, PTEN
regulation of protein serine/threonine kinase activity (GO:0071900) 3.583TNFRSF10B, EGFR, PTEN
positive regulation of cell communication (GO:0010647) 2.413TNFRSF10B, EGFR, PTEN
positive regulation of catalytic activity (GO:0043085) 2.43TNFRSF10B, PTEN, EGFR
regulation of signaling (GO:0023051) 1.723TNFRSF10B, EGFR, PTEN
cellular protein metabolic process (GO:0044267) 1.633ING3, EGFR, PTEN
cellular response to stimulus (GO:0051716) 1.973TNFRSF10B, EGFR, PTEN
regulation of cell communication (GO:0010646) 1.733TNFRSF10B, PTEN, EGFR
positive regulation of transferase activity (GO:0051347) 3.313TNFRSF10B, PTEN, EGFR
cellular macromolecule metabolic process (GO:0044260) 0.933ING3, EGFR, PTEN
regulation of signal transduction (GO:0009966) 1.843TNFRSF10B, PTEN, EGFR
response to lipid (GO:0033993) 3.113TNFRSF10B, EGFR, PTEN
positive regulation of phosphorus metabolic process (GO:0010562) 2.783TNFRSF10B, PTEN, EGFR
regulation of kinase activity (GO:0043549) 3.073TNFRSF10B, EGFR, PTEN
regulation of protein metabolic process (GO:0051246) 1.933TNFRSF10B, EGFR, PTEN
positive regulation of protein metabolic process (GO:0051247) 2.433TNFRSF10B, PTEN, EGFR
positive regulation of apoptotic process (GO:0043065) 3.383TNFRSF10B, ING3, PTEN
organic substance metabolic process (GO:0071704) 0.633ING3, EGFR, PTEN
negative regulation of apoptotic process (GO:0043066) 3.043TNFRSF10B, PTEN, EGFR
positive regulation of cellular protein metabolic process (GO:0032270) 2.493TNFRSF10B, EGFR, PTEN
positive regulation of molecular function (GO:0044093) 2.233TNFRSF10B, PTEN, EGFR
regulation of protein modification process (GO:0031399) 2.323TNFRSF10B, EGFR, PTEN
regulation of molecular function (GO:0065009) 1.783TNFRSF10B, EGFR, PTEN
negative regulation of programmed cell death (GO:0043069) 3.023TNFRSF10B, PTEN, EGFR
positive regulation of programmed cell death (GO:0043068) 3.383TNFRSF10B, ING3, PTEN
developmental process (GO:0032502) 1.363TNFRSF10B, PTEN, EGFR
response to oxygen-containing compound (GO:1901700) 2.573TNFRSF10B, EGFR, PTEN
regulation of catalytic activity (GO:0050790) 1.973TNFRSF10B, PTEN, EGFR
positive regulation of phosphate metabolic process (GO:0045937) 2.783TNFRSF10B, PTEN, EGFR
response to abiotic stimulus (GO:0009628) 2.83TNFRSF10B, EGFR, PTEN
negative regulation of cell death (GO:0060548) 2.953TNFRSF10B, PTEN, EGFR
regulation of protein kinase activity (GO:0045859) 3.153TNFRSF10B, PTEN, EGFR
cellular protein modification process (GO:0006464) 1.793ING3, EGFR, PTEN
single-organism developmental process (GO:0044767) 1.493TNFRSF10B, EGFR, PTEN
macromolecule modification (GO:0043412) 1.733ING3, EGFR, PTEN
protein modification process (GO:0036211) 1.793ING3, EGFR, PTEN
metabolic process (GO:0008152) 0.583ING3, EGFR, PTEN
response to chemical (GO:0042221) 1.983TNFRSF10B, PTEN, EGFR
regulation of intracellular signal transduction (GO:1902531) 2.313TNFRSF10B, EGFR, PTEN
response to organic substance (GO:0010033) 2.23TNFRSF10B, PTEN, EGFR
regulation of phosphorylation (GO:0042325) 2.53TNFRSF10B, EGFR, PTEN
primary metabolic process (GO:0044238) 0.693ING3, EGFR, PTEN
positive regulation of phosphorylation (GO:0042327) 2.93TNFRSF10B, EGFR, PTEN
regulation of cellular protein metabolic process (GO:0032268) 1.993TNFRSF10B, EGFR, PTEN
negative regulation of signal transduction (GO:0009968) 2.753TNFRSF10B, EGFR, PTEN
single-multicellular organism process (GO:0044707) 1.783TNFRSF10B, PTEN, EGFR
protein metabolic process (GO:0019538) 1.453ING3, EGFR, PTEN
response to stimulus (GO:0050896) 1.223TNFRSF10B, PTEN, EGFR
anatomical structure development (GO:0048856) 1.583TNFRSF10B, PTEN, EGFR
response to stress (GO:0006950) 1.83TNFRSF10B, PTEN, EGFR
regulation of transferase activity (GO:0051338) 2.883TNFRSF10B, PTEN, EGFR
macromolecule metabolic process (GO:0043170) 0.833ING3, EGFR, PTEN
positive regulation of signal transduction (GO:0009967) 2.53TNFRSF10B, PTEN, EGFR
regulation of protein phosphorylation (GO:0001932) 2.573TNFRSF10B, PTEN, EGFR
positive regulation of protein phosphorylation (GO:0001934) 2.953TNFRSF10B, EGFR, PTEN
negative regulation of cell communication (GO:0010648) 2.663TNFRSF10B, EGFR, PTEN
positive regulation of apoptotic signaling pathway (GO:2001235) 4.582TNFRSF10B, PTEN
regulation of extrinsic apoptotic signaling pathway (GO:2001236) 4.692TNFRSF10B, PTEN
regulation of apoptotic signaling pathway (GO:2001233) 3.832TNFRSF10B, PTEN
regulation of transport (GO:0051049) 2.242EGFR, PTEN
activation of protein kinase activity (GO:0032147) 4.082TNFRSF10B, EGFR
behavior (GO:0007610) 3.472EGFR, PTEN
learning or memory (GO:0007611) 4.332EGFR, PTEN
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242EGFR, PTEN
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.542EGFR, PTEN
regulation of protein kinase B signaling (GO:0051896) 4.922EGFR, PTEN
single-organism metabolic process (GO:0044710) 1.632EGFR, PTEN
regulation of localization (GO:0032879) 1.942EGFR, PTEN
negative regulation of macromolecule metabolic process (GO:0010605) 2.012EGFR, PTEN
cellular developmental process (GO:0048869) 1.822EGFR, PTEN
peptidyl-amino acid modification (GO:0018193) 2.982ING3, EGFR
animal organ development (GO:0048513) 2.532EGFR, PTEN
establishment of protein localization (GO:0045184) 2.532ING1, EGFR
developmental process involved in reproduction (GO:0003006) 3.362EGFR, PTEN
phosphatidylinositol metabolic process (GO:0046488) 4.462EGFR, PTEN
glycerolipid metabolic process (GO:0046486) 3.912EGFR, PTEN
system process (GO:0003008) 2.32EGFR, PTEN
single organism reproductive process (GO:0044702) 2.732EGFR, PTEN
response to external stimulus (GO:0009605) 2.552TNFRSF10B, PTEN
cell motility (GO:0048870) 3.022EGFR, PTEN
single-organism behavior (GO:0044708) 3.792EGFR, PTEN
response to organonitrogen compound (GO:0010243) 3.22EGFR, PTEN
immune system process (GO:0002376) 2.292TNFRSF10B, PTEN
cellular response to stress (GO:0033554) 2.512TNFRSF10B, PTEN
organophosphate metabolic process (GO:0019637) 3.042EGFR, PTEN
regulation of cyclin-dependent protein kinase activity (GO:1904029) 5.212EGFR, PTEN
chromatin modification (GO:0016568) 4.062ING3, ING1
regulation of catabolic process (GO:0009894) 3.522EGFR, PTEN
negative regulation of metabolic process (GO:0009892) 1.932EGFR, PTEN
positive regulation of biosynthetic process (GO:0009891) 2.292ING1, EGFR
movement of cell or subcellular component (GO:0006928) 2.612EGFR, PTEN
positive regulation of gene expression (GO:0010628) 2.352ING1, EGFR
positive regulation of protein serine/threonine kinase activity (GO:0071902) 4.062TNFRSF10B, EGFR
organic substance biosynthetic process (GO:1901576) 1.342ING3, PTEN
regulation of mitotic cell cycle (GO:0007346) 3.712EGFR, PTEN
positive regulation of hydrolase activity (GO:0051345) 2.912TNFRSF10B, EGFR
regulation of cellular component movement (GO:0051270) 3.082EGFR, PTEN
cell migration (GO:0016477) 3.122EGFR, PTEN
organ morphogenesis (GO:0009887) 3.552EGFR, PTEN
lipid metabolic process (GO:0006629) 2.682EGFR, PTEN
transport (GO:0006810) 1.512ING1, EGFR
tissue development (GO:0009888) 3.272EGFR, PTEN
positive regulation of MAPK cascade (GO:0043410) 3.572EGFR, PTEN
programmed cell death (GO:0012501) 3.12TNFRSF10B, PTEN
establishment of localization (GO:0051234) 1.482ING1, EGFR
phosphatidylinositol-mediated signaling (GO:0048015) 4.932EGFR, PTEN
inositol lipid-mediated signaling (GO:0048017) 4.912EGFR, PTEN
regulation of hydrolase activity (GO:0051336) 2.532TNFRSF10B, EGFR
positive regulation of protein kinase activity (GO:0045860) 3.612TNFRSF10B, EGFR
regulation of cell cycle phase transition (GO:1901987) 4.152EGFR, PTEN
regulation of response to stress (GO:0080134) 2.532EGFR, PTEN
regulation of cellular response to stress (GO:0080135) 3.42EGFR, PTEN
cognition (GO:0050890) 4.22EGFR, PTEN
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392ING1, EGFR
regulation of cell motility (GO:2000145) 3.162EGFR, PTEN
regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902041) 5.722TNFRSF10B, PTEN
cellular biosynthetic process (GO:0044249) 1.372ING3, PTEN
regulation of protein catabolic process (GO:0042176) 3.832EGFR, PTEN
regulation of mitotic cell cycle phase transition (GO:1901990) 4.232EGFR, PTEN
cellular response to chemical stimulus (GO:0070887) 2.572EGFR, PTEN
anatomical structure morphogenesis (GO:0009653) 2.532EGFR, PTEN
response to organic cyclic compound (GO:0014070) 3.072EGFR, PTEN
regulation of MAPK cascade (GO:0043408) 3.222EGFR, PTEN
response to endogenous stimulus (GO:0009719) 2.792EGFR, PTEN
negative regulation of protein metabolic process (GO:0051248) 2.822EGFR, PTEN
regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle (GO:0031657) 7.532EGFR, PTEN
response to nitrogen compound (GO:1901698) 3.122EGFR, PTEN
positive regulation of kinase activity (GO:0033674) 3.542TNFRSF10B, EGFR
regulation of cell cycle process (GO:0010564) 3.52EGFR, PTEN
positive regulation of cell proliferation (GO:0008284) 3.012EGFR, PTEN
negative regulation of cell proliferation (GO:0008285) 3.262ING1, PTEN
phospholipid metabolic process (GO:0006644) 3.882EGFR, PTEN
cell proliferation (GO:0008283) 3.232EGFR, PTEN
neurological system process (GO:0050877) 2.642EGFR, PTEN
regulation of cell growth (GO:0001558) 3.752ING1, EGFR
positive regulation of transcription, DNA-templated (GO:0045893) 2.562ING1, EGFR
cellular lipid metabolic process (GO:0044255) 2.922EGFR, PTEN
regulation of phosphatidylinositol 3-kinase signaling (GO:0014066) 4.792EGFR, PTEN
lipid modification (GO:0030258) 4.372EGFR, PTEN
regulation of epithelial cell proliferation (GO:0050678) 4.062EGFR, PTEN
regulation of G1/S transition of mitotic cell cycle (GO:2000045) 4.812EGFR, PTEN
positive regulation of RNA metabolic process (GO:0051254) 2.512ING1, EGFR
positive regulation of RNA biosynthetic process (GO:1902680) 2.542ING1, EGFR
positive regulation of proteolysis (GO:0045862) 3.862TNFRSF10B, PTEN
positive regulation of ERK1 and ERK2 cascade (GO:0070374) 4.562EGFR, PTEN
regulation of ERK1 and ERK2 cascade (GO:0070372) 4.232EGFR, PTEN
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562ING1, EGFR
negative regulation of growth (GO:0045926) 4.242ING1, PTEN
glycerophospholipid metabolic process (GO:0006650) 4.132EGFR, PTEN
regulation of cellular localization (GO:0060341) 3.032EGFR, PTEN
positive regulation of cellular biosynthetic process (GO:0031328) 2.32ING1, EGFR
macromolecular complex subunit organization (GO:0043933) 2.142ING3, ING1
cell death (GO:0008219) 3.052TNFRSF10B, PTEN
multicellular organism development (GO:0007275) 2.542TNFRSF10B, EGFR
response to estradiol (GO:0032355) 4.732EGFR, PTEN
chromatin organization (GO:0006325) 3.282ING3, ING1
cellular component morphogenesis (GO:0032989) 3.52EGFR, PTEN
regulation of cell migration (GO:0030334) 3.232EGFR, PTEN
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352ING1, EGFR
apoptotic process (GO:0006915) 3.142TNFRSF10B, PTEN
reproductive process (GO:0022414) 2.552EGFR, PTEN
biosynthetic process (GO:0009058) 1.322ING3, PTEN
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292ING1, EGFR
localization (GO:0051179) 1.42ING1, EGFR
locomotion (GO:0040011) 2.912EGFR, PTEN
regulation of locomotion (GO:0040012) 3.122EGFR, PTEN
regulation of cell cycle (GO:0051726) 2.932EGFR, PTEN
regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079) 5.262EGFR, PTEN
regulation of cell cycle G1/S phase transition (GO:1902806) 4.742EGFR, PTEN
phosphate-containing compound metabolic process (GO:0006796) 2.162EGFR, PTEN
phosphorus metabolic process (GO:0006793) 2.152EGFR, PTEN
regulation of proteolysis (GO:0030162) 3.22TNFRSF10B, PTEN

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle (GO:0031657) -7.530.002EGFR, PTEN
negative regulation of T cell activation (GO:0050868) NEW5.260.04TNFRSF10B, PTEN, EGFR
glial cell-derived neurotrophic factor receptor signaling pathway (GO:0035860) NEW8.120.009EGFR, PTEN
regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001239) NEW5.860.012TNFRSF10B, PTEN, EGFR
negative regulation of protein autophosphorylation (GO:0031953) NEW7.330.029EGFR, PTEN
tongue development (GO:0043586) NEW7.430.024EGFR, PTEN
negative regulation of nitric oxide mediated signal transduction (GO:0010751) NEW8.630.002EGFR, PTEN
prepulse inhibition (GO:0060134) NEW7.240.032EGFR, PTEN
regulation of cell death (GO:0010941) -2.430.002ING1, EGFR, TNFRSF10B, ING3, PTEN
positive regulation of T-helper 1 cell differentiation (GO:0045627) NEW7.940.015EGFR, PTEN
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.115ING1, TNFRSF10B, EGFR, PTEN, ING3
cytoplasm (GO:0005737) 1.014ING1, EGFR, PTEN, ING3
intracellular membrane-bounded organelle (GO:0043231) 0.64ING1, EGFR, PTEN, ING3
nucleus (GO:0005634) 1.074ING1, EGFR, PTEN, ING3
intracellular organelle part (GO:0044446) 0.814ING1, EGFR, PTEN, ING3
intracellular organelle (GO:0043229) 0.514ING1, EGFR, PTEN, ING3
nuclear part (GO:0044428) 1.554ING1, EGFR, PTEN, ING3
intracellular part (GO:0044424) 0.284ING1, EGFR, PTEN, ING3
membrane-bounded organelle (GO:0043227) 0.474ING1, EGFR, PTEN, ING3
organelle (GO:0043226) 0.44ING1, EGFR, PTEN, ING3
organelle part (GO:0044422) 0.794ING1, EGFR, PTEN, ING3
nucleoplasm (GO:0005654) 1.893ING3, ING1, PTEN
membrane part (GO:0044425) 0.953TNFRSF10B, PTEN, EGFR
membrane (GO:0016020) 0.683TNFRSF10B, PTEN, EGFR
plasma membrane part (GO:0044459) 1.953TNFRSF10B, EGFR, PTEN
plasma membrane (GO:0005886) 1.393TNFRSF10B, PTEN, EGFR
protein complex (GO:0043234) 1.512ING3, EGFR
plasma membrane region (GO:0098590) 2.972EGFR, PTEN
macromolecular complex (GO:0032991) 1.352ING3, EGFR
integral component of membrane (GO:0016021) 1.142TNFRSF10B, EGFR
intracellular (GO:0005622) 2.372TNFRSF10B, EGFR
cytoplasmic part (GO:0044444) 0.822EGFR, PTEN
extracellular region (GO:0005576) 2.182EGFR, PTEN
nucleoplasm part (GO:0044451) 3.222ING3, PTEN
cell surface (GO:0009986) 3.442TNFRSF10B, EGFR
intrinsic component of membrane (GO:0031224) 1.132TNFRSF10B, EGFR

NET-GE enrichment

Term New enriched termICP valueGenes
cell pole (GO:0060187) NEW9.110.002EGFR, PTEN