Disease table of LACRIMOAURICULODENTODIGITAL SYNDROME OMIM ID: 149730

Gene-disease associations table

GeneAssociated with LACRIMOAURICULODENTODIGITAL SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
FGF10ClinVar, OMIM, HUMSAVARHGNC link5p122149730, 180920
FGFR2ClinVar, OMIM, HUMSAVARHGNC link10q26.1311101400, 101200, 149730, 614592, 123500, 207410, 613659, 123150, 609579, 101600, 123790
FGFR3ClinVar, OMIM, HUMSAVARHGNC link4p16.316603956, 109800, 149730, 101400, 100800, 610474, 182000, 162900, 612247, 146000, 602849, 114500, 273300, 187600, 187601, 616482

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
FGF10YES3TBX20, GATA4, ISL10
FGFR3YES5SP1, SP3, SP4, STAT1, SHOX0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
FGF10FGFR2Yes1FGFR2
FGFR2FGFR3No2FGF8, FGF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
FGF10FGFR2Yesactivation, binding11SALL4, FGF20, FGF22, FGF6, FGF7, FGF23, FGF4, FGF9, FGF2, FGF18, FGF1
FGF10FGFR3Yesactivation, binding11FGF20, FGF22, FGF6, FGF7, FGF23, FGF4, IHH, FGF9, FGF2, FGF18, FGF1
FGFR2FGFR3No-81FGF18, FGF20, WWP1, SH3GLB1, FGF6, FGF10, ANGPT4, EFNA5, SH3KBP1, EPN3, FGF4, EFNA4, IRS1, PGF, VEGFB, CBLC, PDGFB, FGF14, ANGPT2, SHC4, EFNA2, FGF1, FGF11, MDM2, NEDD4L, CRK, PLCB3, PLCB2, FGF2, SHC2, FGF23, SOS2, CRKL, SH3GL2, SOS1, VEGFC, SHC1, SHC3, ANGPT1, EPS15, SMURF1, PDGFA, ITCH, HGF, PLCB1, HRAS, FGF19, FGF7, PHLPP1, SH3GL3, KITLG, PLCB4, FIGF, FGF22, TRAF6, CSF1, CBLB, GRB2, FGF8, EFNA1, FGF17, RNF41, STAT3, IGF1, FGF13, EPN2, FGF21, CBL, VEGFA, PHLPP2, FGF5, INS, FGF12, PDGFD, FGF9, EPN1, EGF, SH3GL1, PDGFC, SH3GLB2, NEDD4

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
FGF10FGFR2Yes2FGF10, FGFR2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
FGF10FGFR3yes, complexThey are in interaction. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Pathways in cancerhsa052003.983FGFR3, FGF10, FGFR2
Rap1 signaling pathwayhsa040154.973FGFR3, FGF10, FGFR2
Ras signaling pathwayhsa040144.93FGFR3, FGF10, FGFR2
MAPK signaling pathwayhsa040104.633FGFR3, FGF10, FGFR2
Regulation of actin cytoskeletonhsa048104.93FGFR3, FGF10, FGFR2
PI3K-Akt signaling pathwayhsa041514.213FGFR3, FGF10, FGFR2
Signaling pathways regulating pluripotency of stem cellshsa045505.62FGFR3, FGFR2
Central carbon metabolism in cancerhsa052306.72FGFR3, FGFR2
Endocytosishsa041444.922FGFR3, FGFR2

NET-GE enrichment

Term New enriched termICP valueGenes
Signaling pathways regulating pluripotency of stem cells (hsa04550) -5.60.002FGFR3, FGF10, FGFR2
Cancers: Specific typesNEW4.10.045FGFR3, FGF10, FGFR2
Pathways in cancer (hsa05200) -3.980.006FGFR3, FGF10, FGFR2
Rap1 signaling pathway (hsa04015) -4.970.001FGFR3, FGF10, FGFR2
Ras signaling pathway (hsa04014) -4.90.008FGFR3, FGF10, FGFR2
Central carbon metabolism in cancer (hsa05230) -6.70.006FGFR3, FGFR2
MAPK signaling pathway (hsa04010) -4.630.013FGFR3, FGF10, FGFR2
Regulation of actin cytoskeleton (hsa04810) -4.90.001FGFR3, FGF10, FGFR2
Cell motilityNEW4.90.001FGFR3, FGF10, FGFR2
Melanoma (hsa05218) NEW6.560.0FGFR3, FGF10, FGFR2
PI3K-Akt signaling pathway (hsa04151) -4.210.004FGFR3, FGF10, FGFR2
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
PI-3K cascade:FGFR4R-HSA-56547206.373FGFR3, FGF10, FGFR2
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.853FGFR3, FGF10, FGFR2
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.263FGFR3, FGF10, FGFR2
NCAM signaling for neurite out-growthR-HSA-3751654.93FGFR3, FGF10, FGFR2
PI3K/AKT activationR-HSA-1982036.323FGFR3, FGF10, FGFR2
Signaling by InterleukinsR-HSA-4491474.713FGFR3, FGF10, FGFR2
RAF/MAP kinase cascadeR-HSA-56730015.153FGFR3, FGF10, FGFR2
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.993FGFR3, FGF10, FGFR2
Immune SystemR-HSA-1682562.373FGFR3, FGF10, FGFR2
Frs2-mediated activationR-HSA-1709685.123FGFR3, FGF10, FGFR2
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.623FGFR3, FGF10, FGFR2
Cytokine Signaling in Immune systemR-HSA-12802153.743FGFR3, FGF10, FGFR2
IGF1R signaling cascadeR-HSA-24289244.853FGFR3, FGF10, FGFR2
Downstream signal transductionR-HSA-1867634.653FGFR3, FGF10, FGFR2
GAB1 signalosomeR-HSA-1802926.313FGFR3, FGF10, FGFR2
PIP3 activates AKT signalingR-HSA-12576046.373FGFR3, FGF10, FGFR2
IRS-related events triggered by IGF1RR-HSA-24289284.853FGFR3, FGF10, FGFR2
Signaling by ERBB4R-HSA-12363944.73FGFR3, FGF10, FGFR2
DAP12 interactionsR-HSA-21721274.563FGFR3, FGF10, FGFR2
Signaling by Insulin receptorR-HSA-747524.733FGFR3, FGF10, FGFR2
Adaptive Immune SystemR-HSA-12802183.193FGFR3, FGF10, FGFR2
Developmental BiologyR-HSA-12667383.483FGFR3, FGF10, FGFR2
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.953FGFR3, FGF10, FGFR2
Downstream signaling of activated FGFR1R-HSA-56546874.713FGFR3, FGF10, FGFR2
MAPK family signaling cascadesR-HSA-56830574.893FGFR3, FGF10, FGFR2
Signaling by LeptinR-HSA-25865525.13FGFR3, FGF10, FGFR2
PI3K CascadeR-HSA-1097046.683FGFR3, FGF10, FGFR2
Signaling by VEGFR-HSA-1941384.663FGFR3, FGF10, FGFR2
Signalling to p38 via RIT and RINR-HSA-1877065.123FGFR3, FGF10, FGFR2
PI-3K cascade:FGFR1R-HSA-56546896.373FGFR3, FGF10, FGFR2
FCERI mediated MAPK activationR-HSA-28717964.323FGFR3, FGF10, FGFR2
IRS-mediated signallingR-HSA-1123994.873FGFR3, FGF10, FGFR2
FRS-mediated FGFR2 signalingR-HSA-56547005.143FGFR3, FGF10, FGFR2
SOS-mediated signallingR-HSA-1124125.153FGFR3, FGF10, FGFR2
FRS-mediated FGFR3 signalingR-HSA-56547065.143FGFR3, FGF10, FGFR2
DiseaseR-HSA-16436853.333FGFR3, FGF10, FGFR2
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.593FGFR3, FGF10, FGFR2
Downstream signaling of activated FGFR3R-HSA-56547084.713FGFR3, FGF10, FGFR2
Insulin receptor signalling cascadeR-HSA-747514.853FGFR3, FGF10, FGFR2
Signaling by FGFR4R-HSA-56547434.693FGFR3, FGF10, FGFR2
Signaling by FGFR in diseaseR-HSA-12260997.493FGFR3, FGF10, FGFR2
Signaling by FGFR3R-HSA-56547414.693FGFR3, FGF10, FGFR2
VEGFA-VEGFR2 PathwayR-HSA-44200974.73FGFR3, FGF10, FGFR2
GRB2 events in ERBB2 signalingR-HSA-19636405.153FGFR3, FGF10, FGFR2
Signaling by FGFRR-HSA-1902364.673FGFR3, FGF10, FGFR2
PI3K/AKT Signaling in CancerR-HSA-22195286.563FGFR3, FGF10, FGFR2
Diseases of signal transductionR-HSA-56632024.893FGFR3, FGF10, FGFR2
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.033FGFR3, FGF10, FGFR2
Interleukin-2 signalingR-HSA-4519275.053FGFR3, FGF10, FGFR2
MAPK1/MAPK3 signalingR-HSA-56849965.113FGFR3, FGF10, FGFR2
Interleukin receptor SHC signalingR-HSA-9125265.093FGFR3, FGF10, FGFR2
Innate Immune SystemR-HSA-1682493.173FGFR3, FGF10, FGFR2
Signaling by SCF-KITR-HSA-14335574.733FGFR3, FGF10, FGFR2
Constitutive Signaling by Aberrant PI3K in CancerR-HSA-22195307.053FGFR3, FGF10, FGFR2
Signaling by PDGFR-HSA-1867974.533FGFR3, FGF10, FGFR2
Signalling to RASR-HSA-1670445.083FGFR3, FGF10, FGFR2
PI3K events in ERBB2 signalingR-HSA-19636426.373FGFR3, FGF10, FGFR2
SHC1 events in EGFR signalingR-HSA-1803365.153FGFR3, FGF10, FGFR2
SHC1 events in ERBB2 signalingR-HSA-12501965.153FGFR3, FGF10, FGFR2
PI-3K cascade:FGFR2R-HSA-56546956.373FGFR3, FGF10, FGFR2
Downstream signaling of activated FGFR2R-HSA-56546964.713FGFR3, FGF10, FGFR2
SHC1 events in ERBB4 signalingR-HSA-12503475.153FGFR3, FGF10, FGFR2
Signaling by EGFRR-HSA-1779294.593FGFR3, FGF10, FGFR2
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.513FGFR3, FGF10, FGFR2
FRS-mediated FGFR1 signalingR-HSA-56546935.143FGFR3, FGF10, FGFR2
Prolonged ERK activation eventsR-HSA-1698935.113FGFR3, FGF10, FGFR2
Signalling to ERKsR-HSA-1876875.043FGFR3, FGF10, FGFR2
Signalling by NGFR-HSA-1665204.233FGFR3, FGF10, FGFR2
Signaling by GPCRR-HSA-3727902.683FGFR3, FGF10, FGFR2
Signaling by FGFR2R-HSA-56547384.683FGFR3, FGF10, FGFR2
GRB2 events in EGFR signalingR-HSA-1798125.153FGFR3, FGF10, FGFR2
Signaling by FGFR1R-HSA-56547364.693FGFR3, FGF10, FGFR2
PI3K events in ERBB4 signalingR-HSA-12503426.373FGFR3, FGF10, FGFR2
ARMS-mediated activationR-HSA-1709845.123FGFR3, FGF10, FGFR2
PI-3K cascade:FGFR3R-HSA-56547106.373FGFR3, FGF10, FGFR2
FRS-mediated FGFR4 signalingR-HSA-56547125.143FGFR3, FGF10, FGFR2
Downstream signaling of activated FGFR4R-HSA-56547164.713FGFR3, FGF10, FGFR2
Signaling by ERBB2R-HSA-12279864.663FGFR3, FGF10, FGFR2
Axon guidanceR-HSA-4224753.933FGFR3, FGF10, FGFR2
VEGFR2 mediated cell proliferationR-HSA-52189215.073FGFR3, FGF10, FGFR2
Signal TransductionR-HSA-1625821.783FGFR3, FGF10, FGFR2
DAP12 signalingR-HSA-24244914.643FGFR3, FGF10, FGFR2
Phospholipase C-mediated cascade; FGFR2R-HSA-56542217.372FGF10, FGFR2
FGFR2b ligand binding and activationR-HSA-1903779.662FGF10, FGFR2
Activated point mutants of FGFR2R-HSA-20335198.892FGF10, FGFR2
FGFR2 ligand binding and activationR-HSA-1902418.662FGF10, FGFR2
Negative regulation of FGFR2 signalingR-HSA-56547277.892FGF10, FGFR2
SHC-mediated cascade:FGFR2R-HSA-56546998.282FGF10, FGFR2
Signaling by FGFR2 in diseaseR-HSA-56552538.232FGF10, FGFR2
FGFR2 mutant receptor activationR-HSA-18391268.892FGF10, FGFR2

NET-GE enrichment

Term New enriched termICP valueGenes
Interleukin-2 signaling (R-HSA-451927) -5.050.003FGFR3, FGF10, FGFR2
Signaling by the B Cell Receptor (BCR) (R-HSA-983705) -4.620.007FGFR3, FGF10, FGFR2
GAB1 signalosome (R-HSA-180292) -6.310.001FGFR3, FGF10, FGFR2
Signaling by VEGF (R-HSA-194138) -4.660.045FGFR3, FGF10, FGFR2
FCERI mediated MAPK activation (R-HSA-2871796) -4.320.042FGFR3, FGF10, FGFR2
IRS-mediated signalling (R-HSA-112399) -4.870.029FGFR3, FGF10, FGFR2
VEGFA-VEGFR2 Pathway (R-HSA-4420097) -4.70.039FGFR3, FGF10, FGFR2
Signaling by FGFR1 in disease (R-HSA-5655302) NEW7.810.0FGFR3, FGF10, FGFR2
Signaling by EGFR (R-HSA-177929) -4.590.05FGFR3, FGF10, FGFR2
PI-3K cascade:FGFR3 (R-HSA-5654710) -6.370.001FGFR3, FGF10, FGFR2
SOS-mediated signalling (R-HSA-112412) -5.150.002FGFR3, FGF10, FGFR2
Downstream signaling of activated FGFR4 (R-HSA-5654716) -4.710.042FGFR3, FGF10, FGFR2
Signaling by ERBB2 (R-HSA-1227986) -4.660.046FGFR3, FGF10, FGFR2
VEGFR2 mediated cell proliferation (R-HSA-5218921) -5.070.003FGFR3, FGF10, FGFR2
Phospholipase C-mediated cascade; FGFR2 (R-HSA-5654221) -7.370.012FGFR3, FGF10, FGFR2
PI3K/AKT activation (R-HSA-198203) -6.320.0FGFR3, FGF10, FGFR2
Phospholipase C-mediated cascade; FGFR3 (R-HSA-5654227) NEW7.520.024FGFR3, FGFR2
GRB2 events in ERBB2 signaling (R-HSA-1963640) -5.150.002FGFR3, FGF10, FGFR2
Frs2-mediated activation (R-HSA-170968) -5.120.003FGFR3, FGF10, FGFR2
PI3K events in ERBB2 signaling (R-HSA-1963642) -6.370.001FGFR3, FGF10, FGFR2
Downstream signal transduction (R-HSA-186763) -4.650.048FGFR3, FGF10, FGFR2
Role of LAT2/NTAL/LAB on calcium mobilization (R-HSA-2730905) -4.950.004FGFR3, FGF10, FGFR2
Signalling to p38 via RIT and RIN (R-HSA-187706) -5.120.003FGFR3, FGF10, FGFR2
FRS-mediated FGFR2 signaling (R-HSA-5654700) -5.140.002FGFR3, FGF10, FGFR2
FRS-mediated FGFR4 signaling (R-HSA-5654712) -5.140.002FGFR3, FGF10, FGFR2
FRS-mediated FGFR3 signaling (R-HSA-5654706) -5.140.002FGFR3, FGF10, FGFR2
SHC-mediated cascade:FGFR3 (R-HSA-5654704) NEW8.810.002FGFR3, FGF10
Downstream signaling of activated FGFR3 (R-HSA-5654708) -4.710.042FGFR3, FGF10, FGFR2
FGFR1 mutant receptor activation (R-HSA-1839124) NEW8.120.011FGFR3, FGFR2
Signaling by FGFR in disease (R-HSA-1226099) -7.490.0FGFR3, FGF10, FGFR2
FGFR2 mutant receptor activation (R-HSA-1839126) -8.890.001FGFR3, FGF10, FGFR2
Fc epsilon receptor (FCERI) signaling (R-HSA-2454202) -4.030.025FGFR3, FGF10, FGFR2
Interleukin receptor SHC signaling (R-HSA-912526) -5.090.003FGFR3, FGF10, FGFR2
SHC-mediated cascade:FGFR4 (R-HSA-5654719) NEW8.460.003FGFR3, FGF10
NGF signalling via TRKA from the plasma membrane (R-HSA-187037) -4.510.009FGFR3, FGF10, FGFR2
Prolonged ERK activation events (R-HSA-169893) -5.110.015FGFR3, FGF10, FGFR2
Signaling by FGFR2 (R-HSA-5654738) -4.680.044FGFR3, FGF10, FGFR2
GRB2 events in EGFR signaling (R-HSA-179812) -5.150.002FGFR3, FGF10, FGFR2
SHC1 events in ERBB4 signaling (R-HSA-1250347) -5.150.002FGFR3, FGF10, FGFR2
PI3K events in ERBB4 signaling (R-HSA-1250342) -6.370.001FGFR3, FGF10, FGFR2
Negative regulation of FGFR3 signaling (R-HSA-5654732) NEW8.120.0FGFR3, FGF10, FGFR2
PI3K Cascade (R-HSA-109704) -6.680.0FGFR3, FGF10, FGFR2
DAP12 interactions (R-HSA-2172127) -4.560.008FGFR3, FGF10, FGFR2
Axon guidance (R-HSA-422475) -3.930.031FGFR3, FGF10, FGFR2
Signaling by FGFR2 in disease (R-HSA-5655253) -8.230.004FGFR3, FGF10, FGFR2
SHC-mediated cascade:FGFR1 (R-HSA-5654688) NEW8.590.003FGFR3, FGF10
Signaling by FGFR3 in disease (R-HSA-5655332) NEW8.520.003FGFR3, FGF10
FGFR1 ligand binding and activation (R-HSA-190242) NEW8.980.001FGFR3, FGF10
FGFR2 ligand binding and activation (R-HSA-190241) -8.660.002FGFR3, FGF10, FGFR2
Signaling by Leptin (R-HSA-2586552) -5.10.003FGFR3, FGF10, FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530) -7.050.0FGFR3, FGF10, FGFR2
IGF1R signaling cascade (R-HSA-2428924) -4.850.03FGFR3, FGF10, FGFR2
IRS-related events triggered by IGF1R (R-HSA-2428928) -4.850.03FGFR3, FGF10, FGFR2
Signaling by Insulin receptor (R-HSA-74752) -4.730.039FGFR3, FGF10, FGFR2
Insulin receptor signalling cascade (R-HSA-74751) -4.850.005FGFR3, FGF10, FGFR2
FGFR2b ligand binding and activation (R-HSA-190377) -9.660.0FGF10, FGFR2
FGFR2c ligand binding and activation (R-HSA-190375) NEW9.280.001FGFR3, FGFR2
Downstream signaling of activated FGFR1 (R-HSA-5654687) -4.710.042FGFR3, FGF10, FGFR2
PI-3K cascade:FGFR4 (R-HSA-5654720) -6.370.001FGFR3, FGF10, FGFR2
PI-3K cascade:FGFR1 (R-HSA-5654689) -6.370.001FGFR3, FGF10, FGFR2
Gastrin-CREB signalling pathway via PKC and MAPK (R-HSA-881907) -4.260.016FGFR3, FGF10, FGFR2
Negative regulation of FGFR1 signaling (R-HSA-5654726) NEW7.980.0FGFR3, FGF10, FGFR2
Negative regulation of FGFR2 signaling (R-HSA-5654727) -7.890.006FGFR3, FGF10, FGFR2
Downstream signaling events of B Cell Receptor (BCR) (R-HSA-1168372) -5.590.001FGFR3, FGF10, FGFR2
PI3K/AKT Signaling in Cancer (R-HSA-2219528) -6.560.0FGFR3, FGF10, FGFR2
Diseases of signal transduction (R-HSA-5663202) -4.890.036FGFR3, FGF10, FGFR2
Signalling to RAS (R-HSA-167044) -5.080.003FGFR3, FGF10, FGFR2
SHC-mediated cascade:FGFR2 (R-HSA-5654699) -8.280.0FGFR3, FGF10, FGFR2
PI-3K cascade:FGFR2 (R-HSA-5654695) -6.370.001FGFR3, FGF10, FGFR2
Downstream signaling of activated FGFR2 (R-HSA-5654696) -4.710.042FGFR3, FGF10, FGFR2
SHC1 events in EGFR signaling (R-HSA-180336) -5.150.002FGFR3, FGF10, FGFR2
FRS-mediated FGFR1 signaling (R-HSA-5654693) -5.140.002FGFR3, FGF10, FGFR2
SHC1 events in ERBB2 signaling (R-HSA-1250196) -5.150.002FGFR3, FGF10, FGFR2
ARMS-mediated activation (R-HSA-170984) -5.120.003FGFR3, FGF10, FGFR2
Signaling by FGFR1 (R-HSA-5654736) -4.690.006FGFR3, FGF10, FGFR2
Signaling by PDGF (R-HSA-186797) -4.530.009FGFR3, FGF10, FGFR2
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (R-HSA-2404192) -4.850.03FGFR3, FGF10, FGFR2
Signaling by Interleukins (R-HSA-449147) -4.710.038FGFR3, FGF10, FGFR2
Negative regulation of FGFR4 signaling (R-HSA-5654733) NEW8.030.007FGF10, FGFR2
Cytokine Signaling in Immune system (R-HSA-1280215) -3.740.046FGFR3, FGF10, FGFR2
Signaling by ERBB4 (R-HSA-1236394) -4.70.006FGFR3, FGF10, FGFR2
MAPK1/MAPK3 signaling (R-HSA-5684996) -5.110.003FGFR3, FGF10, FGFR2
MAPK family signaling cascades (R-HSA-5683057) -4.890.004FGFR3, FGF10, FGFR2
PIP3 activates AKT signaling (R-HSA-1257604) -6.370.001FGFR3, FGF10, FGFR2
Phospholipase C-mediated cascade: FGFR1 (R-HSA-5654219) NEW7.430.0FGFR3, FGF10, FGFR2
RAF/MAP kinase cascade (R-HSA-5673001) -5.150.002FGFR3, FGF10, FGFR2
Signaling by FGFR4 (R-HSA-5654743) -4.690.006FGFR3, FGF10, FGFR2
Signaling by FGFR3 (R-HSA-5654741) -4.690.043FGFR3, FGF10, FGFR2
Activated point mutants of FGFR2 (R-HSA-2033519) -8.890.001FGFR3, FGF10, FGFR2
Signaling by FGFR (R-HSA-190236) -4.670.007FGFR3, FGF10, FGFR2
Signaling by SCF-KIT (R-HSA-1433557) -4.730.006FGFR3, FGF10, FGFR2
NCAM signaling for neurite out-growth (R-HSA-375165) -4.90.004FGFR3, FGF10, FGFR2
DAP12 signaling (R-HSA-2424491) -4.640.007FGFR3, FGF10, FGFR2
Interleukin-3, 5 and GM-CSF signaling (R-HSA-512988) -4.990.017FGFR3, FGF10, FGFR2
Signalling by NGF (R-HSA-166520) -4.230.017FGFR3, FGF10, FGFR2
Signalling to ERKs (R-HSA-187687) -5.040.003FGFR3, FGF10, FGFR2
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934) 5.613FGFR3, FGF10, FGFR2
Ras guanyl-nucleotide exchange factor activity (GO:0005088) 4.313FGFR3, FGF10, FGFR2
protein binding (GO:0005515) 0.463FGFR3, FGF10, FGFR2
catalytic activity (GO:0003824) 1.053FGFR3, FGF10, FGFR2
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.083FGFR3, FGF10, FGFR2
1-phosphatidylinositol-3-kinase activity (GO:0016303) 5.983FGFR3, FGF10, FGFR2
kinase activity (GO:0016301) 2.933FGFR3, FGF10, FGFR2
guanyl-nucleotide exchange factor activity (GO:0005085) 4.023FGFR3, FGF10, FGFR2
phosphatidylinositol kinase activity (GO:0052742) 5.813FGFR3, FGF10, FGFR2
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.773FGFR3, FGF10, FGFR2
phosphatidylinositol bisphosphate kinase activity (GO:0052813) 5.563FGFR3, FGF10, FGFR2
transferase activity (GO:0016740) 1.953FGFR3, FGF10, FGFR2
protein tyrosine kinase activity (GO:0004713) 4.543FGFR3, FGF10, FGFR2
phosphatidylinositol 3-kinase activity (GO:0035004) 5.493FGFR3, FGF10, FGFR2
protein kinase activity (GO:0004672) 3.273FGFR3, FGF10, FGFR2
molecular function regulator (GO:0098772) 2.513FGFR3, FGF10, FGFR2
carbohydrate derivative binding (GO:0097367) 2.033FGFR3, FGF10, FGFR2
binding (GO:0005488) 0.183FGFR3, FGF10, FGFR2
signaling receptor activity (GO:0038023) 2.492FGFR3, FGFR2
purine ribonucleoside triphosphate binding (GO:0035639) 2.222FGFR3, FGFR2
molecular transducer activity (GO:0060089) 2.322FGFR3, FGFR2
receptor activity (GO:0004872) 2.322FGFR3, FGFR2
signal transducer activity (GO:0004871) 2.282FGFR3, FGFR2
heterocyclic compound binding (GO:1901363) 1.062FGFR3, FGFR2
purine nucleoside binding (GO:0001883) 2.222FGFR3, FGFR2
nucleoside binding (GO:0001882) 2.212FGFR3, FGFR2
sulfur compound binding (GO:1901681) 4.322FGF10, FGFR2
growth factor binding (GO:0019838) 4.892FGFR3, FGFR2
nucleotide binding (GO:0000166) 1.962FGFR3, FGFR2
transmembrane receptor protein tyrosine kinase activity (GO:0004714) 5.552FGFR3, FGFR2
nucleoside phosphate binding (GO:1901265) 1.962FGFR3, FGFR2
ribonucleoside binding (GO:0032549) 2.222FGFR3, FGFR2
purine nucleotide binding (GO:0017076) 2.192FGFR3, FGFR2
ATP binding (GO:0005524) 2.432FGFR3, FGFR2
fibroblast growth factor binding (GO:0017134) 6.522FGFR3, FGFR2
small molecule binding (GO:0036094) 1.892FGFR3, FGFR2
heparin binding (GO:0008201) 4.682FGF10, FGFR2
adenyl nucleotide binding (GO:0030554) 2.42FGFR3, FGFR2
organic cyclic compound binding (GO:0097159) 1.052FGFR3, FGFR2
glycosaminoglycan binding (GO:0005539) 4.422FGF10, FGFR2
transmembrane signaling receptor activity (GO:0004888) 2.572FGFR3, FGFR2
adenyl ribonucleotide binding (GO:0032559) 2.412FGFR3, FGFR2
ribonucleotide binding (GO:0032553) 2.192FGFR3, FGFR2
fibroblast growth factor-activated receptor activity (GO:0005007) 8.132FGFR3, FGFR2
purine ribonucleotide binding (GO:0032555) 2.22FGFR3, FGFR2
transmembrane receptor protein kinase activity (GO:0019199) 5.322FGFR3, FGFR2
purine ribonucleoside binding (GO:0032550) 2.222FGFR3, FGFR2
transmembrane receptor activity (GO:0099600) 2.532FGFR3, FGFR2

NET-GE enrichment

Term New enriched termICP valueGenes
sulfur compound binding (GO:1901681) -4.320.02FGF10, FGFR2
growth factor receptor binding (GO:0070851) NEW4.870.0FGFR3, FGF10, FGFR2
growth factor binding (GO:0019838) -4.890.007FGFR3, FGF10, FGFR2
fibroblast growth factor binding (GO:0017134) -6.520.0FGFR3, FGF10, FGFR2
glycosaminoglycan binding (GO:0005539) -4.420.017FGF10, FGFR2
transmembrane receptor protein tyrosine kinase activity (GO:0004714) -5.550.002FGFR3, FGFR2
protein tyrosine kinase activity (GO:0004713) -4.540.011FGFR3, FGF10, FGFR2
fibroblast growth factor-activated receptor activity (GO:0005007) -8.130.0FGFR3, FGFR2
transmembrane receptor protein kinase activity (GO:0019199) -5.320.0FGFR3, FGF10, FGFR2
fibroblast growth factor receptor binding (GO:0005104) NEW6.410.001FGFR3, FGF10
heparin binding (GO:0008201) -4.680.009FGF10, FGFR2
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of phosphate metabolic process (GO:0019220) 2.353FGFR3, FGF10, FGFR2
regulation of primary metabolic process (GO:0080090) 1.083FGFR3, FGF10, FGFR2
developmental growth (GO:0048589) 4.053FGFR3, FGF10, FGFR2
positive regulation of response to stimulus (GO:0048584) 2.183FGFR3, FGF10, FGFR2
regulation of response to stimulus (GO:0048583) 1.543FGFR3, FGF10, FGFR2
signal transduction (GO:0007165) 1.283FGFR3, FGF10, FGFR2
cell surface receptor signaling pathway (GO:0007166) 2.093FGFR3, FGF10, FGFR2
enzyme linked receptor protein signaling pathway (GO:0007167) 3.243FGFR3, FGF10, FGFR2
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.543FGFR3, FGF10, FGFR2
signal transduction by protein phosphorylation (GO:0023014) 3.793FGFR3, FGF10, FGFR2
single-organism metabolic process (GO:0044710) 1.633FGFR3, FGF10, FGFR2
single-organism biosynthetic process (GO:0044711) 2.83FGFR3, FGF10, FGFR2
regulation of metabolic process (GO:0019222) 1.023FGFR3, FGF10, FGFR2
regulation of signal transduction (GO:0009966) 1.843FGFR3, FGF10, FGFR2
positive regulation of signal transduction (GO:0009967) 2.53FGFR3, FGF10, FGFR2
peptidyl-tyrosine modification (GO:0018212) 4.473FGFR3, FGF10, FGFR2
peptidyl-amino acid modification (GO:0018193) 2.983FGFR3, FGF10, FGFR2
positive regulation of molecular function (GO:0044093) 2.233FGFR3, FGF10, FGFR2
phosphorylation (GO:0016310) 2.633FGFR3, FGF10, FGFR2
positive regulation of biological process (GO:0048518) 1.23FGFR3, FGF10, FGFR2
negative regulation of biological process (GO:0048519) 1.333FGFR3, FGF10, FGFR2
regulation of cell proliferation (GO:0042127) 2.413FGFR3, FGF10, FGFR2
regulation of macromolecule metabolic process (GO:0060255) 1.083FGFR3, FGF10, FGFR2
phosphatidylinositol metabolic process (GO:0046488) 4.463FGFR3, FGF10, FGFR2
glycerolipid metabolic process (GO:0046486) 3.913FGFR3, FGF10, FGFR2
regulation of phosphorylation (GO:0042325) 2.53FGFR3, FGF10, FGFR2
single organism signaling (GO:0044700) 3.253FGFR3, FGF10, FGFR2
positive regulation of phosphorylation (GO:0042327) 2.93FGFR3, FGF10, FGFR2
single-multicellular organism process (GO:0044707) 1.783FGFR3, FGF10, FGFR2
protein metabolic process (GO:0019538) 1.453FGFR3, FGF10, FGFR2
organophosphate metabolic process (GO:0019637) 3.043FGFR3, FGF10, FGFR2
positive regulation of metabolic process (GO:0009893) 1.743FGFR3, FGF10, FGFR2
organ growth (GO:0035265) 6.333FGFR3, FGF10, FGFR2
intracellular signal transduction (GO:0035556) 2.393FGFR3, FGF10, FGFR2
regulation of biological process (GO:0050789) 0.453FGFR3, FGF10, FGFR2
cellular protein metabolic process (GO:0044267) 1.633FGFR3, FGF10, FGFR2
regulation of cell communication (GO:0010646) 1.733FGFR3, FGF10, FGFR2
positive regulation of GTPase activity (GO:0043547) 3.283FGFR3, FGF10, FGFR2
positive regulation of hydrolase activity (GO:0051345) 2.913FGFR3, FGF10, FGFR2
regulation of GTPase activity (GO:0043087) 3.213FGFR3, FGF10, FGFR2
biological regulation (GO:0065007) 0.393FGFR3, FGF10, FGFR2
positive regulation of catalytic activity (GO:0043085) 2.43FGFR3, FGF10, FGFR2
phosphatidylinositol phosphorylation (GO:0046854) 5.193FGFR3, FGF10, FGFR2
regulation of molecular function (GO:0065009) 1.783FGFR3, FGF10, FGFR2
organ morphogenesis (GO:0009887) 3.553FGFR3, FGF10, FGFR2
lipid metabolic process (GO:0006629) 2.683FGFR3, FGF10, FGFR2
regulation of developmental process (GO:0050793) 2.13FGFR3, FGF10, FGFR2
regulation of catalytic activity (GO:0050790) 1.973FGFR3, FGF10, FGFR2
tissue development (GO:0009888) 3.273FGFR3, FGF10, FGFR2
regulation of cellular process (GO:0050794) 0.53FGFR3, FGF10, FGFR2
positive regulation of MAPK cascade (GO:0043410) 3.573FGFR3, FGF10, FGFR2
macromolecule modification (GO:0043412) 1.733FGFR3, FGF10, FGFR2
protein modification process (GO:0036211) 1.793FGFR3, FGF10, FGFR2
metabolic process (GO:0008152) 0.583FGFR3, FGF10, FGFR2
positive regulation of intracellular signal transduction (GO:1902533) 2.953FGFR3, FGF10, FGFR2
regulation of intracellular signal transduction (GO:1902531) 2.313FGFR3, FGF10, FGFR2
organophosphate biosynthetic process (GO:0090407) 3.673FGFR3, FGF10, FGFR2
inositol lipid-mediated signaling (GO:0048017) 4.913FGFR3, FGF10, FGFR2
positive regulation of macromolecule metabolic process (GO:0010604) 1.813FGFR3, FGF10, FGFR2
regulation of hydrolase activity (GO:0051336) 2.533FGFR3, FGF10, FGFR2
single-organism developmental process (GO:0044767) 1.493FGFR3, FGF10, FGFR2
phospholipid biosynthetic process (GO:0008654) 4.393FGFR3, FGF10, FGFR2
positive regulation of protein modification process (GO:0031401) 2.73FGFR3, FGF10, FGFR2
cellular developmental process (GO:0048869) 1.823FGFR3, FGF10, FGFR2
MAPK cascade (GO:0000165) 3.913FGFR3, FGF10, FGFR2
cell differentiation (GO:0030154) 2.143FGFR3, FGF10, FGFR2
positive regulation of signaling (GO:0023056) 2.413FGFR3, FGF10, FGFR2
cellular biosynthetic process (GO:0044249) 1.373FGFR3, FGF10, FGFR2
signaling (GO:0023052) 3.253FGFR3, FGF10, FGFR2
regulation of signaling (GO:0023051) 1.723FGFR3, FGF10, FGFR2
positive regulation of cell communication (GO:0010647) 2.413FGFR3, FGF10, FGFR2
anatomical structure morphogenesis (GO:0009653) 2.533FGFR3, FGF10, FGFR2
fibroblast growth factor receptor signaling pathway (GO:0008543) 5.33FGFR3, FGF10, FGFR2
single-organism process (GO:0044699) 0.483FGFR3, FGF10, FGFR2
regulation of MAPK cascade (GO:0043408) 3.223FGFR3, FGF10, FGFR2
phosphatidylinositol-mediated signaling (GO:0048015) 4.933FGFR3, FGF10, FGFR2
positive regulation of phosphorus metabolic process (GO:0010562) 2.783FGFR3, FGF10, FGFR2
regulation of protein metabolic process (GO:0051246) 1.933FGFR3, FGF10, FGFR2
positive regulation of protein metabolic process (GO:0051247) 2.433FGFR3, FGF10, FGFR2
lipid phosphorylation (GO:0046834) 5.133FGFR3, FGF10, FGFR2
positive regulation of cellular protein metabolic process (GO:0032270) 2.493FGFR3, FGF10, FGFR2
regulation of protein modification process (GO:0031399) 2.323FGFR3, FGF10, FGFR2
positive regulation of cell proliferation (GO:0008284) 3.013FGFR3, FGF10, FGFR2
phospholipid metabolic process (GO:0006644) 3.883FGFR3, FGF10, FGFR2
multicellular organismal process (GO:0032501) 1.453FGFR3, FGF10, FGFR2
cell proliferation (GO:0008283) 3.233FGFR3, FGF10, FGFR2
cellular process (GO:0009987) 0.263FGFR3, FGF10, FGFR2
phosphatidylinositol biosynthetic process (GO:0006661) 4.943FGFR3, FGF10, FGFR2
cellular lipid metabolic process (GO:0044255) 2.923FGFR3, FGF10, FGFR2
regulation of phosphatidylinositol 3-kinase signaling (GO:0014066) 4.793FGFR3, FGF10, FGFR2
lipid modification (GO:0030258) 4.373FGFR3, FGF10, FGFR2
regulation of cellular protein metabolic process (GO:0032268) 1.993FGFR3, FGF10, FGFR2
macromolecule metabolic process (GO:0043170) 0.833FGFR3, FGF10, FGFR2
glycerophospholipid biosynthetic process (GO:0046474) 4.623FGFR3, FGF10, FGFR2
positive regulation of ERK1 and ERK2 cascade (GO:0070374) 4.563FGFR3, FGF10, FGFR2
regulation of ERK1 and ERK2 cascade (GO:0070372) 4.233FGFR3, FGF10, FGFR2
developmental process (GO:0032502) 1.363FGFR3, FGF10, FGFR2
glycerophospholipid metabolic process (GO:0006650) 4.133FGFR3, FGF10, FGFR2
positive regulation of cellular metabolic process (GO:0031325) 1.813FGFR3, FGF10, FGFR2
regulation of cellular metabolic process (GO:0031323) 1.073FGFR3, FGF10, FGFR2
peptidyl-tyrosine phosphorylation (GO:0018108) 4.483FGFR3, FGF10, FGFR2
glycerolipid biosynthetic process (GO:0045017) 4.533FGFR3, FGF10, FGFR2
growth (GO:0040007) 3.83FGFR3, FGF10, FGFR2
organic substance metabolic process (GO:0071704) 0.633FGFR3, FGF10, FGFR2
protein phosphorylation (GO:0006468) 2.893FGFR3, FGF10, FGFR2
positive regulation of phosphate metabolic process (GO:0045937) 2.783FGFR3, FGF10, FGFR2
organic substance biosynthetic process (GO:1901576) 1.343FGFR3, FGF10, FGFR2
cellular protein modification process (GO:0006464) 1.793FGFR3, FGF10, FGFR2
regulation of phosphorus metabolic process (GO:0051174) 2.353FGFR3, FGF10, FGFR2
biosynthetic process (GO:0009058) 1.323FGFR3, FGF10, FGFR2
single-organism cellular process (GO:0044763) 0.653FGFR3, FGF10, FGFR2
phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) 5.843FGFR3, FGF10, FGFR2
cell-cell signaling (GO:0007267) 3.353FGFR3, FGF10, FGFR2
cell communication (GO:0007154) 3.043FGFR3, FGF10, FGFR2
lipid biosynthetic process (GO:0008610) 3.493FGFR3, FGF10, FGFR2
primary metabolic process (GO:0044238) 0.693FGFR3, FGF10, FGFR2
cellular macromolecule metabolic process (GO:0044260) 0.933FGFR3, FGF10, FGFR2
anatomical structure development (GO:0048856) 1.583FGFR3, FGF10, FGFR2
cellular metabolic process (GO:0044237) 0.693FGFR3, FGF10, FGFR2
phosphate-containing compound metabolic process (GO:0006796) 2.163FGFR3, FGF10, FGFR2
phosphorus metabolic process (GO:0006793) 2.153FGFR3, FGF10, FGFR2
regulation of protein phosphorylation (GO:0001932) 2.573FGFR3, FGF10, FGFR2
positive regulation of protein phosphorylation (GO:0001934) 2.953FGFR3, FGF10, FGFR2
positive regulation of cellular process (GO:0048522) 1.33FGFR3, FGF10, FGFR2
regulation of smoothened signaling pathway (GO:0008589) 5.622FGF10, FGFR2
positive regulation of lipase activity (GO:0060193) 5.542FGFR3, FGFR2
regulation of Wnt signaling pathway (GO:0030111) 3.982FGF10, FGFR2
cellular component organization or biogenesis (GO:0071840) 1.222FGF10, FGFR2
morphogenesis of an epithelium (GO:0002009) 4.082FGF10, FGFR2
positive regulation of cell cycle (GO:0045787) 3.942FGF10, FGFR2
mesenchymal cell differentiation involved in lung development (GO:0060915) 9.042FGF10, FGFR2
otic vesicle formation (GO:0030916) 7.782FGF10, FGFR2
animal organ development (GO:0048513) 2.532FGF10, FGFR2
epithelial cell differentiation (GO:0030855) 3.982FGF10, FGFR2
mesenchymal cell differentiation (GO:0048762) 6.512FGF10, FGFR2
regulation of phospholipase activity (GO:0010517) 5.572FGFR3, FGFR2
developmental process involved in reproduction (GO:0003006) 3.362FGF10, FGFR2
regulation of RNA biosynthetic process (GO:2001141) 1.552FGF10, FGFR2
epithelial cell proliferation involved in salivary gland morphogenesis (GO:0060664) 7.942FGF10, FGFR2
branch elongation involved in salivary gland morphogenesis (GO:0060667) 9.042FGF10, FGFR2
hair follicle morphogenesis (GO:0031069) 6.472FGF10, FGFR2
single organism reproductive process (GO:0044702) 2.732FGF10, FGFR2
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731) 4.622FGFR3, FGF10
regulation of peptidyl-tyrosine phosphorylation (GO:0050730) 4.352FGFR3, FGF10
axis elongation (GO:0003401) 6.842FGF10, FGFR2
regulation of canonical Wnt signaling pathway (GO:0060828) 4.262FGF10, FGFR2
embryonic organ morphogenesis (GO:0048562) 4.922FGF10, FGFR2
digestive tract development (GO:0048565) 5.492FGF10, FGFR2
positive regulation of biosynthetic process (GO:0009891) 2.292FGF10, FGFR2
positive regulation of canonical Wnt signaling pathway (GO:0090263) 4.952FGF10, FGFR2
embryonic organ development (GO:0048568) 4.862FGF10, FGFR2
limb bud formation (GO:0060174) 7.432FGF10, FGFR2
positive regulation of Wnt signaling pathway (GO:0030177) 4.72FGF10, FGFR2
morphogenesis of a branching structure (GO:0001763) 4.712FGF10, FGFR2
(GO:1905330) 4.562FGF10, FGFR2
bone mineralization (GO:0030282) 6.092FGFR3, FGFR2
positive regulation of transferase activity (GO:0051347) 3.312FGFR3, FGF10
regulation of kinase activity (GO:0043549) 3.072FGFR3, FGF10
cellular component organization (GO:0016043) 1.242FGF10, FGFR2
anatomical structure formation involved in morphogenesis (GO:0048646) 3.012FGF10, FGFR2
odontogenesis (GO:0042476) 5.192FGF10, FGFR2
embryonic digestive tract morphogenesis (GO:0048557) 6.92FGF10, FGFR2
embryonic pattern specification (GO:0009880) 5.82FGF10, FGFR2
regulation of biosynthetic process (GO:0009889) 1.372FGF10, FGFR2
programmed cell death (GO:0012501) 3.12FGFR3, FGFR2
branch elongation of an epithelium (GO:0060602) 7.162FGF10, FGFR2
regulation of multicellular organismal process (GO:0051239) 1.872FGF10, FGFR2
lateral sprouting from an epithelium (GO:0060601) 7.652FGF10, FGFR2
cell fate commitment (GO:0045165) 4.722FGF10, FGFR2
regulation of transferase activity (GO:0051338) 2.882FGFR3, FGF10
regulation of transcription, DNA-templated (GO:0006355) 1.562FGF10, FGFR2
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392FGF10, FGFR2
regulation of macromolecule biosynthetic process (GO:0010556) 1.432FGF10, FGFR2
positive regulation of kinase activity (GO:0033674) 3.542FGFR3, FGF10
regulation of developmental growth (GO:0048638) 4.042FGFR3, FGFR2
regulation of lipase activity (GO:0060191) 5.312FGFR3, FGFR2
biomineral tissue development (GO:0031214) 5.412FGFR3, FGFR2
lacrimal gland development (GO:0032808) 7.782FGF10, FGFR2
mammary gland bud formation (GO:0060615) 9.042FGF10, FGFR2
fibroblast growth factor receptor signaling pathway involved in mammary gland specification (GO:0060595) 9.042FGF10, FGFR2
protein autophosphorylation (GO:0046777) 4.462FGFR3, FGFR2
regulation of cellular response to growth factor stimulus (GO:0090287) 4.292FGF10, FGFR2
positive regulation of multicellular organismal process (GO:0051240) 2.492FGF10, FGFR2
regulation of anatomical structure morphogenesis (GO:0022603) 2.792FGF10, FGFR2
branching involved in salivary gland morphogenesis (GO:0060445) 7.332FGF10, FGFR2
regulation of morphogenesis of a branching structure (GO:0060688) 5.762FGF10, FGFR2
gland morphogenesis (GO:0022612) 6.362FGF10, FGFR2
developmental growth involved in morphogenesis (GO:0060560) 5.152FGF10, FGFR2
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562FGF10, FGFR2
negative regulation of cell proliferation (GO:0008285) 3.262FGF10, FGFR2
epithelium development (GO:0060429) 4.572FGF10, FGFR2
regulation of nucleic acid-templated transcription (GO:1903506) 1.552FGF10, FGFR2
regulation of cell differentiation (GO:0045595) 2.422FGF10, FGFR2
prostate gland epithelium morphogenesis (GO:0060740) 6.732FGF10, FGFR2
positive regulation of transcription, DNA-templated (GO:0045893) 2.562FGF10, FGFR2
bud elongation involved in lung branching (GO:0060449) 7.782FGF10, FGFR2
regulation of epithelial cell proliferation (GO:0050678) 4.062FGF10, FGFR2
positive regulation of epithelial cell proliferation (GO:0050679) 4.672FGF10, FGFR2
positive regulation of developmental process (GO:0051094) 2.772FGF10, FGFR2
regulation of RNA metabolic process (GO:0051252) 1.522FGF10, FGFR2
positive regulation of RNA metabolic process (GO:0051254) 2.512FGF10, FGFR2
epithelial cell proliferation (GO:0050673) 5.212FGF10, FGFR2
positive regulation of RNA biosynthetic process (GO:1902680) 2.542FGF10, FGFR2
positive regulation of gene expression (GO:0010628) 2.352FGF10, FGFR2
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.812FGF10, FGFR2
epidermis morphogenesis (GO:0048730) 7.782FGF10, FGFR2
system development (GO:0048731) 2.922FGFR3, FGF10
gland development (GO:0048732) 4.152FGF10, FGFR2
morphogenesis of embryonic epithelium (GO:0016331) 6.472FGF10, FGFR2
lung development (GO:0030324) 5.132FGF10, FGFR2
positive regulation of cellular biosynthetic process (GO:0031328) 2.32FGF10, FGFR2
regulation of cellular biosynthetic process (GO:0031326) 1.382FGF10, FGFR2
bone morphogenesis (GO:0060349) 6.22FGFR3, FGFR2
molting cycle process (GO:0022404) 5.542FGF10, FGFR2
hair cycle process (GO:0022405) 5.542FGF10, FGFR2
cell death (GO:0008219) 3.052FGFR3, FGFR2
angiogenesis (GO:0001525) 4.152FGF10, FGFR2
pattern specification process (GO:0007389) 3.792FGF10, FGFR2
regulation of growth (GO:0040008) 3.262FGFR3, FGFR2
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462FGF10, FGFR2
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242FGF10, FGFR2
tissue morphogenesis (GO:0048729) 3.872FGF10, FGFR2
regulation of gene expression (GO:0010468) 1.372FGF10, FGFR2
embryonic morphogenesis (GO:0048598) 3.722FGF10, FGFR2
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352FGF10, FGFR2
morphogenesis of a branching epithelium (GO:0061138) 4.772FGF10, FGFR2
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432FGF10, FGFR2
apoptotic process (GO:0006915) 3.142FGFR3, FGFR2
reproductive process (GO:0022414) 2.552FGF10, FGFR2
regulation of nitrogen compound metabolic process (GO:0051171) 1.362FGF10, FGFR2
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292FGF10, FGFR2
tube development (GO:0035295) 4.412FGF10, FGFR2
inner ear morphogenesis (GO:0042472) 5.622FGF10, FGFR2
regulation of cell cycle (GO:0051726) 2.932FGF10, FGFR2
positive regulation of phospholipase activity (GO:0010518) 5.762FGFR3, FGFR2
regulation of multicellular organismal development (GO:2000026) 2.312FGF10, FGFR2
regulation of organ morphogenesis (GO:2000027) 4.222FGF10, FGFR2
lung alveolus development (GO:0048286) 6.152FGF10, FGFR2
negative regulation of cellular process (GO:0048523) 1.412FGF10, FGFR2

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of smoothened signaling pathway (GO:0008589) -5.620.001FGFR3, FGF10, FGFR2
developmental growth (GO:0048589) -4.050.033FGFR3, FGF10, FGFR2
regulation of developmental growth (GO:0048638) -4.040.026FGFR3, FGF10, FGFR2
negative regulation of epithelial cell proliferation (GO:0050680) NEW4.980.007FGFR3, FGF10, FGFR2
regulation of Wnt signaling pathway (GO:0030111) -3.980.001FGFR3, FGF10, FGFR2
multicellular organism growth (GO:0035264) NEW5.370.002FGFR3, FGF10, FGFR2
organ growth (GO:0035265) -6.330.002FGF10, FGFR2
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) -3.540.02FGFR3, FGF10, FGFR2
alveolar secondary septum development (GO:0061144) NEW9.730.0FGFR3, FGF10
stem cell differentiation (GO:0048863) NEW5.720.023FGF10, FGFR2
positive regulation of cell cycle (GO:0045787) -3.940.008FGFR3, FGF10, FGFR2
mesenchymal cell differentiation involved in lung development (GO:0060915) -9.040.0FGF10, FGFR2
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway (GO:0090080) NEW8.120.0FGFR3, FGFR2
otic vesicle formation (GO:0030916) -7.780.0FGF10, FGFR2
negative regulation of mitosis (GO:0045839) NEW6.260.012FGFR3, FGFR2
glandular epithelial cell differentiation (GO:0002067) NEW6.510.024FGF10, FGFR2
epithelial cell development (GO:0002064) NEW4.920.006FGFR3, FGF10, FGFR2
mesenchymal cell differentiation (GO:0048762) -6.510.022FGF10, FGFR2
neurotrophin signaling pathway (GO:0038179) NEW6.550.002FGFR3, FGF10, FGFR2
mesenchymal cell proliferation (GO:0010463) NEW7.160.003FGFR3, FGFR2
epidermal growth factor receptor signaling pathway (GO:0007173) NEW5.720.001FGFR3, FGF10, FGFR2
epithelial cell proliferation involved in salivary gland morphogenesis (GO:0060664) -7.940.0FGF10, FGFR2
cellular response to growth factor stimulus (GO:0071363) NEW4.270.02FGFR3, FGF10, FGFR2
response to peptide hormone (GO:0043434) NEW4.060.005FGFR3, FGF10, FGFR2
branch elongation involved in salivary gland morphogenesis (GO:0060667) -9.040.0FGF10, FGFR2
hair follicle morphogenesis (GO:0031069) -6.470.005FGF10, FGFR2
positive regulation of epithelial cell proliferation (GO:0050679) -4.670.019FGFR3, FGF10, FGFR2
single organism signaling (GO:0044700) -3.250.045FGFR3, FGF10, FGFR2
replacement ossification (GO:0036075) NEW6.470.0FGFR3, FGF10, FGFR2
direct ossification (GO:0036072) NEW7.940.002FGFR3, FGF10
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731) -4.620.015FGFR3, FGF10, FGFR2
regulation of peptidyl-tyrosine phosphorylation (GO:0050730) -4.350.033FGFR3, FGF10, FGFR2
response to organonitrogen compound (GO:0010243) NEW3.20.036FGFR3, FGF10, FGFR2
somatic stem cell maintenance (GO:0035019) NEW5.520.012FGFR3, FGF10
axis elongation (GO:0003401) -6.840.004FGF10, FGFR2
negative regulation of nuclear division (GO:0051784) NEW5.940.018FGFR3, FGFR2
regulation of canonical Wnt signaling pathway (GO:0060828) -4.260.0FGFR3, FGF10, FGFR2
positive regulation of canonical Wnt signaling pathway (GO:0090263) -4.950.0FGFR3, FGF10, FGFR2
enzyme linked receptor protein signaling pathway (GO:0007167) -3.240.049FGFR3, FGF10, FGFR2
ventricular septum development (GO:0003281) NEW6.360.018FGF10, FGFR2
craniofacial suture morphogenesis (GO:0097094) NEW7.090.012FGF10, FGFR2
forebrain neuron development (GO:0021884) NEW6.730.023FGF10, FGFR2
positive regulation of Wnt signaling pathway (GO:0030177) -4.70.004FGFR3, FGF10, FGFR2
embryonic axis specification (GO:0000578) NEW6.360.039FGF10, FGFR2
regulation of epithelial cell proliferation involved in lung morphogenesis (GO:2000794) NEW7.650.003FGF10, FGFR2
bone mineralization (GO:0030282) -6.090.009FGFR3, FGFR2
regulation of mitotic cell cycle (GO:0007346) NEW3.710.007FGFR3, FGF10, FGFR2
cell morphogenesis involved in differentiation (GO:0000904) NEW4.670.019FGFR3, FGF10, FGFR2
immune response-regulating signaling pathway (GO:0002764) NEW3.720.019FGFR3, FGF10, FGFR2
immune response-regulating cell surface receptor signaling pathway (GO:0002768) NEW3.960.01FGFR3, FGF10, FGFR2
cellular response to fibroblast growth factor stimulus (GO:0044344) NEW6.40.001FGFR3, FGF10, FGFR2
signal transduction by phosphorylation (GO:0023014) -3.790.028FGFR3, FGF10, FGFR2
embryonic digestive tract morphogenesis (GO:0048557) -6.90.02FGF10, FGFR2
embryonic pattern specification (GO:0009880) -5.80.02FGF10, FGFR2
negative regulation of smoothened signaling pathway (GO:0045879) NEW6.550.028FGFR3, FGF10
tissue development (GO:0009888) -3.270.028FGFR3, FGF10, FGFR2
positive regulation of MAPK cascade (GO:0043410) -3.570.005FGFR3, FGF10, FGFR2
chondrocyte proliferation (GO:0035988) NEW7.330.002FGFR3, FGF10
branch elongation of an epithelium (GO:0060602) -7.160.002FGF10, FGFR2
lateral sprouting from an epithelium (GO:0060601) -7.650.0FGF10, FGFR2
neurotrophin TRK receptor signaling pathway (GO:0048011) NEW6.960.002FGFR3, FGF10, FGFR2
positive regulation of intracellular signal transduction (GO:1902533) -2.950.038FGFR3, FGF10, FGFR2
phosphatidylinositol-mediated signaling (GO:0048015) -4.930.0FGFR3, FGF10, FGFR2
inositol lipid-mediated signaling (GO:0048017) -4.910.004FGFR3, FGF10, FGFR2
Fc-epsilon receptor signaling pathway (GO:0038095) NEW4.840.003FGFR3, FGF10, FGFR2
Fc receptor signaling pathway (GO:0038093) NEW4.450.041FGFR3, FGF10, FGFR2
regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947) NEW6.430.032FGF10, FGFR2
positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949) NEW6.960.008FGF10, FGFR2
response to nitrogen compound (GO:1901698) NEW3.120.046FGFR3, FGF10, FGFR2
cellular response to nitrogen compound (GO:1901699) NEW3.790.009FGFR3, FGF10, FGFR2
digestive tract morphogenesis (GO:0048546) NEW6.780.019FGFR3, FGFR2
response to fibroblast growth factor (GO:0071774) NEW6.170.017FGFR3, FGF10, FGFR2
positive regulation of lipase activity (GO:0060193) -5.540.047FGFR3, FGFR2
cranial suture morphogenesis (GO:0060363) NEW7.530.003FGF10, FGFR2
lacrimal gland development (GO:0032808) -7.780.001FGF10, FGFR2
mammary gland bud formation (GO:0060615) -9.040.0FGF10, FGFR2
positive regulation of cardiac muscle cell proliferation (GO:0060045) NEW6.780.025FGF10, FGFR2
fibroblast growth factor receptor signaling pathway involved in mammary gland specification (GO:0060595) -9.040.0FGF10, FGFR2
signaling (GO:0023052) -3.250.045FGFR3, FGF10, FGFR2
ERBB signaling pathway (GO:0038127) NEW5.360.015FGFR3, FGF10, FGFR2
regulation of cardiac muscle cell proliferation (GO:0060043) NEW6.330.049FGF10, FGFR2
inner ear receptor cell differentiation (GO:0060113) NEW7.020.009FGFR3, FGFR2
fibroblast growth factor receptor signaling pathway (GO:0008543) -5.30.007FGFR3, FGF10, FGFR2
response to growth factor (GO:0070848) NEW4.140.022FGFR3, FGF10, FGFR2
regulation of MAPK cascade (GO:0043408) -3.220.017FGFR3, FGF10, FGFR2
cellular response to peptide hormone stimulus (GO:0071375) NEW4.630.002FGFR3, FGF10, FGFR2
regulation of cell cycle process (GO:0010564) NEW3.50.012FGFR3, FGF10, FGFR2
branching involved in salivary gland morphogenesis (GO:0060445) -7.330.005FGF10, FGFR2
regulation of morphogenesis of a branching structure (GO:0060688) -5.760.016FGF10, FGFR2
bud elongation involved in lung branching (GO:0060449) -7.780.0FGF10, FGFR2
developmental growth involved in morphogenesis (GO:0060560) -5.150.0FGFR3, FGF10, FGFR2
negative regulation of cell proliferation (GO:0008285) -3.260.025FGFR3, FGF10, FGFR2
insulin receptor signaling pathway (GO:0008286) NEW5.330.0FGFR3, FGF10, FGFR2
cell proliferation (GO:0008283) -3.230.027FGFR3, FGF10, FGFR2
limb bud formation (GO:0060174) -7.430.001FGF10, FGFR2
lung epithelium development (GO:0060428) NEW7.330.0FGFR3, FGF10
epithelium development (GO:0060429) -4.570.002FGFR3, FGF10, FGFR2
lens fiber cell development (GO:0070307) NEW7.530.004FGFR3, FGFR2
cellular response to hormone stimulus (GO:0032870) NEW3.990.011FGFR3, FGF10, FGFR2
prostate gland epithelium morphogenesis (GO:0060740) -6.730.023FGF10, FGFR2
positive regulation of keratinocyte proliferation (GO:0010838) NEW7.530.001FGF10, FGFR2
regulation of epithelial cell proliferation (GO:0050678) -4.060.002FGFR3, FGF10, FGFR2
positive regulation of cell division (GO:0051781) NEW5.350.002FGFR3, FGF10, FGFR2
endochondral ossification (GO:0001958) NEW6.470.0FGFR3, FGF10, FGFR2
intramembranous ossification (GO:0001957) NEW7.940.002FGFR3, FGF10
negative regulation of cell cycle process (GO:0010948) NEW4.370.002FGFR3, FGF10, FGFR2
epithelial cell proliferation (GO:0050673) -5.210.032FGFR3, FGF10, FGFR2
stem cell proliferation (GO:0072089) NEW6.070.0FGFR3, FGF10, FGFR2
positive regulation of ERK1 and ERK2 cascade (GO:0070374) -4.560.0FGFR3, FGF10, FGFR2
regulation of ERK1 and ERK2 cascade (GO:0070372) -4.230.017FGFR3, FGF10, FGFR2
morphogenesis of embryonic epithelium (GO:0016331) -6.470.005FGF10, FGFR2
bone morphogenesis (GO:0060349) -6.20.004FGFR3, FGFR2
molting cycle process (GO:0022404) -5.540.002FGFR3, FGF10, FGFR2
hair cycle process (GO:0022405) -5.540.002FGFR3, FGF10, FGFR2
cellular response to insulin stimulus (GO:0032869) NEW5.290.026FGFR3, FGF10, FGFR2
response to insulin (GO:0032868) NEW4.720.002FGFR3, FGF10, FGFR2
negative regulation of glial cell differentiation (GO:0045686) NEW6.430.04FGFR3, FGF10
cell fate commitment (GO:0045165) -4.720.012FGFR3, FGF10, FGFR2
morphogenesis of an epithelium (GO:0002009) -4.080.003FGFR3, FGF10, FGFR2
response to estradiol (GO:0032355) NEW4.730.005FGFR3, FGF10, FGFR2
growth (GO:0040007) -3.80.004FGFR3, FGF10, FGFR2
cellular response to organonitrogen compound (GO:0071417) NEW3.870.008FGFR3, FGF10, FGFR2
tissue morphogenesis (GO:0048729) -3.870.005FGFR3, FGF10, FGFR2
hematopoietic or lymphoid organ development (GO:0048534) NEW4.490.034FGFR3, FGF10, FGFR2
positive regulation of epithelial cell proliferation involved in lung morphogenesis (GO:0060501) NEW7.940.001FGF10, FGFR2
regulation of organ growth (GO:0046620) NEW5.410.002FGFR3, FGF10, FGFR2
anterior/posterior axis specification, embryo (GO:0008595) NEW7.650.004FGF10, FGFR2
biomineral tissue development (GO:0031214) -5.410.031FGFR3, FGFR2
cell-cell signaling (GO:0007267) -3.350.04FGFR3, FGF10, FGFR2
mesenchyme development (GO:0060485) NEW5.70.0FGFR3, FGF10, FGFR2
cellular response to oxygen-containing compound (GO:1901701) NEW3.220.04FGFR3, FGF10, FGFR2
cardiac septum development (GO:0003279) NEW5.940.045FGF10, FGFR2
outflow tract septum morphogenesis (GO:0003148) NEW7.090.012FGF10, FGFR2
positive regulation of phospholipase activity (GO:0010518) -5.760.038FGFR3, FGFR2
response to peptide (GO:1901652) NEW3.940.006FGFR3, FGF10, FGFR2
cellular response to peptide (GO:1901653) NEW4.520.002FGFR3, FGF10, FGFR2
lung alveolus development (GO:0048286) -6.150.009FGF10, FGFR2
regulation of phospholipase activity (GO:0010517) -5.570.047FGFR3, FGFR2
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell surface (GO:0009986) 3.443FGFR3, FGF10, FGFR2
nucleus (GO:0005634) 1.073FGFR3, FGF10, FGFR2
membrane (GO:0016020) 0.683FGFR3, FGF10, FGFR2
cell part (GO:0044464) 0.113FGFR3, FGF10, FGFR2
intracellular organelle (GO:0043229) 0.513FGFR3, FGF10, FGFR2
extracellular region (GO:0005576) 2.183FGFR3, FGF10, FGFR2
plasma membrane (GO:0005886) 1.393FGFR3, FGF10, FGFR2
intracellular part (GO:0044424) 0.283FGFR3, FGF10, FGFR2
membrane-bounded organelle (GO:0043227) 0.473FGFR3, FGF10, FGFR2
organelle (GO:0043226) 0.43FGFR3, FGF10, FGFR2
intracellular membrane-bounded organelle (GO:0043231) 0.63FGFR3, FGF10, FGFR2
cytoplasm (GO:0005737) 1.012FGFR3, FGFR2
Golgi apparatus (GO:0005794) 2.72FGFR3, FGFR2
vesicle (GO:0031982) 1.642FGFR3, FGFR2
cytoplasmic, membrane-bounded vesicle (GO:0016023) 3.122FGFR3, FGFR2
cytoplasmic vesicle (GO:0031410) 2.872FGFR3, FGFR2
integral component of membrane (GO:0016021) 1.142FGFR3, FGFR2
extracellular matrix (GO:0031012) 3.812FGF10, FGFR2
cytoplasmic part (GO:0044444) 0.822FGFR3, FGFR2
intracellular vesicle (GO:0097708) 2.862FGFR3, FGFR2
intrinsic component of plasma membrane (GO:0031226) 2.532FGFR3, FGFR2
integral component of plasma membrane (GO:0005887) 2.572FGFR3, FGFR2
membrane part (GO:0044425) 0.952FGFR3, FGFR2
membrane-bounded vesicle (GO:0031988) 1.712FGFR3, FGFR2
plasma membrane part (GO:0044459) 1.952FGFR3, FGFR2
extracellular region part (GO:0044421) 1.572FGF10, FGFR2
intrinsic component of membrane (GO:0031224) 1.132FGFR3, FGFR2

NET-GE enrichment

Term New enriched termICP valueGenes
cell surface (GO:0009986) -3.440.001FGFR3, FGF10, FGFR2
anchoring junction (GO:0070161) NEW3.610.016FGFR3, FGF10, FGFR2
extracellular matrix (GO:0031012) -3.810.007FGFR3, FGF10, FGFR2
extracellular region (GO:0005576) -2.180.021FGFR3, FGF10, FGFR2
adherens junction (GO:0005912) NEW3.660.015FGFR3, FGF10, FGFR2
side of membrane (GO:0098552) NEW4.220.006FGFR3, FGF10, FGFR2
cell-substrate adherens junction (GO:0005924) NEW3.830.009FGFR3, FGF10, FGFR2
focal adhesion (GO:0005925) NEW3.830.008FGFR3, FGF10, FGFR2
proteinaceous extracellular matrix (GO:0005578) NEW4.010.003FGFR3, FGF10, FGFR2
cell-substrate junction (GO:0030055) NEW3.820.009FGFR3, FGF10, FGFR2