Gene | Associated with TESTICULAR GERM CELL TUMOR in | Link to HGNC | Cytogenetic band | Number of associated diseases | Associated diseases |
---|---|---|---|---|---|
STK11 | ClinVar, OMIM, HUMSAVAR | HGNC link | 19p13.3 | 4 | 175200, 273300, PS155600, 260350 |
STK10 | HUMSAVAR | HGNC link | 5q35.1 | 1 | 273300 |
KIT | ClinVar, OMIM | HGNC link | 4q12 | 5 | 601626, 172800, 273300, 606764, 154800 |
BCL10 | ClinVar | HGNC link | 1p22.3 | 5 | 273300, 156240, 137245, 605027, 616098 |
FGFR3 | OMIM, HUMSAVAR | HGNC link | 4p16.3 | 16 | 603956, 109800, 149730, 101400, 100800, 610474, 182000, 162900, 612247, 146000, 602849, 114500, 273300, 187600, 187601, 616482 |
Download the disease annotation in CSV format
regulated gene | associated to this disease | # TFs | TFs | # TFs associated with this disease | TFs associated with this disease |
---|---|---|---|---|---|
STK11 | YES | 4 | SP1, NFYB, NFYA, NR1H4 | 0 | |
KIT | YES | 4 | SP1, TFAP2A, MITF, RBMX | 0 | |
FGFR3 | YES | 5 | SP1, SP3, SP4, STAT1, SHOX | 0 |
Gene1 | Gene2 | Direct Interaction | Number of shared interactors | Shared genes in interaction |
---|---|---|---|---|
STK11 | FGFR3 | No | 2 | CDC37, HSP90AA1 |
STK10 | KIT | No | 1 | CD81 |
STK10 | BCL10 | No | 1 | XPO1 |
KIT | FGFR3 | No | 2 | GRB2, SOCS1 |
Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)
Gene1 | Gene2 | Direct Interaction | Interaction mode | Number of shared interactors | Shared genes in interaction |
---|---|---|---|---|---|
STK11 | KIT | No | - | 7 | STAT3, PHLPP1, HSP90AA1, PHLPP2, IRS1, MYC, VEGFA |
STK11 | BCL10 | No | - | 1 | PHLPP2 |
STK11 | FGFR3 | No | - | 6 | STAT3, PHLPP1, HSP90AA1, PHLPP2, IRS1, VEGFA |
STK10 | KIT | No | - | 1 | IL2 |
KIT | BCL10 | No | - | 4 | UBC, PHLPP2, STAT5A, TRAF6 |
KIT | FGFR3 | No | - | 81 | FGF18, FGF20, WWP1, SH3GLB1, FGF4, FGF6, FGF10, ANGPT4, PLCB4, SH3KBP1, EPN3, EFNA5, EFNA4, IRS1, PGF, VEGFB, CBLC, PDGFB, FGF14, ANGPT2, SHC4, EFNA2, FGF1, FGF11, MDM2, NEDD4L, CRK, PLCB3, PLCB2, FGF2, SHC2, FGF23, CRKL, SH3GL2, SOS1, VEGFC, SHC1, HSP90AA1, SHC3, ANGPT1, EPS15, SMURF1, PDGFA, FGF9, HGF, PLCB1, HRAS, FGF19, FGF7, PHLPP1, SH3GL3, KITLG, GRB2, FIGF, FGF22, TRAF6, CSF1, CBLB, FGF8, EFNA1, FGF17, RNF41, STAT3, IGF1, FGF13, EPN2, FGF21, CBL, VEGFA, PHLPP2, FGF5, INS, FGF12, PDGFD, ITCH, EPN1, EGF, SH3GL1, PDGFC, SH3GLB2, NEDD4 |
BCL10 | FGFR3 | No | - | 2 | PHLPP2, TRAF6 |
Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)
KEGG term | KEGG term ID | IC | Number of genes with the same term | Genes |
---|---|---|---|---|
PI3K-Akt signaling pathway | hsa04151 | 4.21 | 3 | FGFR3, KIT, STK11 |
Rap1 signaling pathway | hsa04015 | 4.97 | 2 | FGFR3, KIT |
Ras signaling pathway | hsa04014 | 4.9 | 2 | FGFR3, KIT |
Central carbon metabolism in cancer | hsa05230 | 6.7 | 2 | FGFR3, KIT |
Endocytosis | hsa04144 | 4.92 | 2 | FGFR3, KIT |
Pathways in cancer | hsa05200 | 3.98 | 2 | FGFR3, KIT |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
Insulin signaling pathway (hsa04910) | NEW | 5.55 | 0.011 | KIT, BCL10, STK11 |
Central carbon metabolism in cancer (hsa05230) | - | 6.7 | 0.02 | FGFR3, KIT |
PI3K-Akt signaling pathway (hsa04151) | - | 4.21 | 0.023 | FGFR3, KIT, STK11 |
REACTOME term | REACTOME term ID | IC | Number of genes with the same term | Genes |
---|---|---|---|---|
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | R-HSA-2404192 | 4.85 | 3 | FGFR3, KIT, STK11 |
Fc epsilon receptor (FCERI) signaling | R-HSA-2454202 | 4.03 | 3 | FGFR3, BCL10, KIT |
Immune System | R-HSA-168256 | 2.37 | 3 | FGFR3, KIT, BCL10 |
Innate Immune System | R-HSA-168249 | 3.17 | 3 | FGFR3, KIT, BCL10 |
Signaling by the B Cell Receptor (BCR) | R-HSA-983705 | 4.62 | 3 | FGFR3, KIT, BCL10 |
IRS-mediated signalling | R-HSA-112399 | 4.87 | 3 | FGFR3, KIT, STK11 |
IGF1R signaling cascade | R-HSA-2428924 | 4.85 | 3 | FGFR3, KIT, STK11 |
Downstream signaling events of B Cell Receptor (BCR) | R-HSA-1168372 | 5.59 | 3 | FGFR3, KIT, BCL10 |
IRS-related events triggered by IGF1R | R-HSA-2428928 | 4.85 | 3 | FGFR3, KIT, STK11 |
Signaling by Insulin receptor | R-HSA-74752 | 4.73 | 3 | FGFR3, KIT, STK11 |
Adaptive Immune System | R-HSA-1280218 | 3.19 | 3 | FGFR3, BCL10, KIT |
Signal Transduction | R-HSA-162582 | 1.78 | 3 | FGFR3, KIT, STK11 |
Insulin receptor signalling cascade | R-HSA-74751 | 4.85 | 3 | FGFR3, KIT, STK11 |
PI-3K cascade:FGFR4 | R-HSA-5654720 | 6.37 | 2 | FGFR3, KIT |
Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 4.26 | 2 | FGFR3, KIT |
NCAM signaling for neurite out-growth | R-HSA-375165 | 4.9 | 2 | FGFR3, KIT |
PI3K/AKT activation | R-HSA-198203 | 6.32 | 2 | FGFR3, KIT |
Signaling by Interleukins | R-HSA-449147 | 4.71 | 2 | FGFR3, KIT |
Interleukin-3, 5 and GM-CSF signaling | R-HSA-512988 | 4.99 | 2 | FGFR3, KIT |
Interleukin-2 signaling | R-HSA-451927 | 5.05 | 2 | FGFR3, KIT |
Frs2-mediated activation | R-HSA-170968 | 5.12 | 2 | FGFR3, KIT |
PI3K events in ERBB2 signaling | R-HSA-1963642 | 6.37 | 2 | FGFR3, KIT |
Cytokine Signaling in Immune system | R-HSA-1280215 | 3.74 | 2 | FGFR3, KIT |
SOS-mediated signalling | R-HSA-112412 | 5.15 | 2 | FGFR3, KIT |
Downstream signal transduction | R-HSA-186763 | 4.65 | 2 | FGFR3, KIT |
GAB1 signalosome | R-HSA-180292 | 6.31 | 2 | FGFR3, KIT |
Signaling by ERBB4 | R-HSA-1236394 | 4.7 | 2 | FGFR3, KIT |
MAPK1/MAPK3 signaling | R-HSA-5684996 | 5.11 | 2 | FGFR3, KIT |
Developmental Biology | R-HSA-1266738 | 3.48 | 2 | FGFR3, KIT |
RAF/MAP kinase cascade | R-HSA-5673001 | 5.15 | 2 | FGFR3, KIT |
Downstream signaling of activated FGFR1 | R-HSA-5654687 | 4.71 | 2 | FGFR3, KIT |
MAPK family signaling cascades | R-HSA-5683057 | 4.89 | 2 | FGFR3, KIT |
PIP3 activates AKT signaling | R-HSA-1257604 | 6.37 | 2 | FGFR3, KIT |
PI3K Cascade | R-HSA-109704 | 6.68 | 2 | FGFR3, STK11 |
Signaling by VEGF | R-HSA-194138 | 4.66 | 2 | FGFR3, KIT |
Signalling to p38 via RIT and RIN | R-HSA-187706 | 5.12 | 2 | FGFR3, KIT |
PI-3K cascade:FGFR1 | R-HSA-5654689 | 6.37 | 2 | FGFR3, KIT |
FCERI mediated MAPK activation | R-HSA-2871796 | 4.32 | 2 | FGFR3, KIT |
Signaling by EGFR | R-HSA-177929 | 4.59 | 2 | FGFR3, KIT |
FRS-mediated FGFR2 signaling | R-HSA-5654700 | 5.14 | 2 | FGFR3, KIT |
DAP12 interactions | R-HSA-2172127 | 4.56 | 2 | FGFR3, KIT |
FRS-mediated FGFR3 signaling | R-HSA-5654706 | 5.14 | 2 | FGFR3, KIT |
Disease | R-HSA-1643685 | 3.33 | 2 | FGFR3, KIT |
Downstream signaling of activated FGFR3 | R-HSA-5654708 | 4.71 | 2 | FGFR3, KIT |
Role of LAT2/NTAL/LAB on calcium mobilization | R-HSA-2730905 | 4.95 | 2 | FGFR3, KIT |
Signaling by FGFR4 | R-HSA-5654743 | 4.69 | 2 | FGFR3, KIT |
Signaling by FGFR3 | R-HSA-5654741 | 4.69 | 2 | FGFR3, KIT |
VEGFA-VEGFR2 Pathway | R-HSA-4420097 | 4.7 | 2 | FGFR3, KIT |
GRB2 events in ERBB2 signaling | R-HSA-1963640 | 5.15 | 2 | FGFR3, KIT |
Signaling by FGFR | R-HSA-190236 | 4.67 | 2 | FGFR3, KIT |
PI3K/AKT Signaling in Cancer | R-HSA-2219528 | 6.56 | 2 | FGFR3, KIT |
Diseases of signal transduction | R-HSA-5663202 | 4.89 | 2 | FGFR3, KIT |
Signaling by Leptin | R-HSA-2586552 | 5.1 | 2 | FGFR3, KIT |
Interleukin receptor SHC signaling | R-HSA-912526 | 5.09 | 2 | FGFR3, KIT |
Signaling by SCF-KIT | R-HSA-1433557 | 4.73 | 2 | FGFR3, KIT |
Constitutive Signaling by Aberrant PI3K in Cancer | R-HSA-2219530 | 7.05 | 2 | FGFR3, KIT |
Signaling by PDGF | R-HSA-186797 | 4.53 | 2 | FGFR3, KIT |
Signalling to RAS | R-HSA-167044 | 5.08 | 2 | FGFR3, KIT |
DAP12 signaling | R-HSA-2424491 | 4.64 | 2 | FGFR3, KIT |
SHC1 events in ERBB2 signaling | R-HSA-1250196 | 5.15 | 2 | FGFR3, KIT |
PI-3K cascade:FGFR2 | R-HSA-5654695 | 6.37 | 2 | FGFR3, KIT |
Downstream signaling of activated FGFR2 | R-HSA-5654696 | 4.71 | 2 | FGFR3, KIT |
SHC1 events in ERBB4 signaling | R-HSA-1250347 | 5.15 | 2 | FGFR3, KIT |
SHC1 events in EGFR signaling | R-HSA-180336 | 5.15 | 2 | FGFR3, KIT |
NGF signalling via TRKA from the plasma membrane | R-HSA-187037 | 4.51 | 2 | FGFR3, KIT |
FRS-mediated FGFR1 signaling | R-HSA-5654693 | 5.14 | 2 | FGFR3, KIT |
Prolonged ERK activation events | R-HSA-169893 | 5.11 | 2 | FGFR3, KIT |
Signalling to ERKs | R-HSA-187687 | 5.04 | 2 | FGFR3, KIT |
Signalling by NGF | R-HSA-166520 | 4.23 | 2 | FGFR3, KIT |
Signaling by GPCR | R-HSA-372790 | 2.68 | 2 | FGFR3, KIT |
Signaling by FGFR2 | R-HSA-5654738 | 4.68 | 2 | FGFR3, KIT |
GRB2 events in EGFR signaling | R-HSA-179812 | 5.15 | 2 | FGFR3, KIT |
Signaling by FGFR1 | R-HSA-5654736 | 4.69 | 2 | FGFR3, KIT |
PI3K events in ERBB4 signaling | R-HSA-1250342 | 6.37 | 2 | FGFR3, KIT |
ARMS-mediated activation | R-HSA-170984 | 5.12 | 2 | FGFR3, KIT |
PI-3K cascade:FGFR3 | R-HSA-5654710 | 6.37 | 2 | FGFR3, KIT |
FRS-mediated FGFR4 signaling | R-HSA-5654712 | 5.14 | 2 | FGFR3, KIT |
Downstream signaling of activated FGFR4 | R-HSA-5654716 | 4.71 | 2 | FGFR3, KIT |
Signaling by ERBB2 | R-HSA-1227986 | 4.66 | 2 | FGFR3, KIT |
Axon guidance | R-HSA-422475 | 3.93 | 2 | FGFR3, KIT |
VEGFR2 mediated cell proliferation | R-HSA-5218921 | 5.07 | 2 | FGFR3, KIT |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (R-HSA-2404192) | - | 4.85 | 0.017 | FGFR3, KIT, STK11 |
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530) | - | 7.05 | 0.035 | FGFR3, KIT |
Signaling by the B Cell Receptor (BCR) (R-HSA-983705) | - | 4.62 | 0.027 | FGFR3, BCL10, KIT |
IRS-mediated signalling (R-HSA-112399) | - | 4.87 | 0.016 | FGFR3, KIT, STK11 |
IGF1R signaling cascade (R-HSA-2428924) | - | 4.85 | 0.017 | FGFR3, KIT, STK11 |
Downstream signaling events of B Cell Receptor (BCR) (R-HSA-1168372) | - | 5.59 | 0.026 | FGFR3, BCL10, KIT |
IRS-related events triggered by IGF1R (R-HSA-2428928) | - | 4.85 | 0.017 | FGFR3, KIT, STK11 |
Signaling by Insulin receptor (R-HSA-74752) | - | 4.73 | 0.022 | FGFR3, KIT, STK11 |
Insulin receptor signalling cascade (R-HSA-74751) | - | 4.85 | 0.017 | FGFR3, KIT, STK11 |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
kinase activity (GO:0016301) | - | 2.93 | 0.003 | FGFR3, KIT, STK11, BCL10, STK10 |
adenyl nucleotide binding (GO:0030554) | - | 2.4 | 0.031 | FGFR3, KIT, STK11, STK10 |
phosphotransferase activity, alcohol group as acceptor (GO:0016773) | - | 3.08 | 0.002 | FGFR3, STK11, KIT, BCL10, STK10 |
receptor signaling protein activity (GO:0005057) | - | 4.76 | 0.006 | FGFR3, KIT, STK10 |
transmembrane receptor protein tyrosine kinase activity (GO:0004714) | - | 5.55 | 0.013 | FGFR3, KIT |
adenyl ribonucleotide binding (GO:0032559) | - | 2.41 | 0.03 | FGFR3, KIT, STK11, STK10 |
protein kinase activity (GO:0004672) | - | 3.27 | 0.001 | FGFR3, BCL10, STK11, STK10, KIT |
protease binding (GO:0002020) | - | 5.08 | 0.014 | KIT, BCL10 |
transferase activity, transferring phosphorus-containing groups (GO:0016772) | - | 2.77 | 0.007 | FGFR3, BCL10, STK11, STK10, KIT |
transmembrane receptor protein kinase activity (GO:0019199) | - | 5.32 | 0.019 | FGFR3, KIT |
ATP binding (GO:0005524) | - | 2.43 | 0.027 | FGFR3, KIT, STK11, BCL10, STK10 |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
lytic vacuole (GO:0000323) | - | 3.89 | 0.04 | FGFR3, BCL10, KIT |
vacuole (GO:0005773) | - | 2.92 | 0.001 | FGFR3, BCL10, KIT |
cytoplasmic side of membrane (GO:0098562) | NEW | 5.81 | 0.023 | FGFR3, KIT |
cytoplasmic side of plasma membrane (GO:0009898) | NEW | 6.0 | 0.002 | FGFR3, KIT |
lysosome (GO:0005764) | - | 3.89 | 0.04 | FGFR3, BCL10, KIT |