Disease table of SAETHRE-CHOTZEN SYNDROME OMIM ID: 101400

Gene-disease associations table

GeneAssociated with SAETHRE-CHOTZEN SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
TWIST1ClinVar, OMIM, HUMSAVARHGNC link7p21.13101400, 180750, 123100
FGFR2OMIMHGNC link10q26.1311101400, 101200, 149730, 614592, 123500, 207410, 613659, 123150, 609579, 101600, 123790
FGFR3ClinVarHGNC link4p16.316603956, 109800, 149730, 101400, 100800, 610474, 182000, 162900, 612247, 146000, 602849, 114500, 273300, 187600, 187601, 616482

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
TWIST1YES35ATM, AKR1C2, CDH2, GDF15, MAPK1, FN1, RBL2, NR2F1, MYB, MMP2, RAP1A, BMI1, FOS, FGF2, RUNX2, ITGB1, CD44, ERBB3, PFDN4, DKK1, AKT2, ESR1, F2R, CDH1, NF1, TIMP1, ICAM1, BCL2, ILK, MAPK3, MMP1, YBX1, CTPS1, SRPX, DNM30
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
TWIST1YES10STAT3, PROX1, POU2F1, RUNX2, HDAC2, EZH2, HMGA1, HIF1A, RELA, PER20
FGFR3YES5SP1, SP3, SP4, STAT1, SHOX0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
TWIST1FGFR2No1STAT3
FGFR2FGFR3No2FGF8, FGF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
TWIST1FGFR2No-2IGF1, RUNX2
TWIST1FGFR3No-2IGF1, SOX2
FGFR2FGFR3No-81FGF18, FGF20, WWP1, SH3GLB1, FGF6, FGF10, ANGPT4, EFNA5, SH3KBP1, EPN3, FGF4, EFNA4, IRS1, PGF, VEGFB, CBLC, PDGFB, FGF14, ANGPT2, SHC4, EFNA2, FGF1, FGF11, MDM2, NEDD4L, CRK, PLCB3, PLCB2, FGF2, SHC2, FGF23, SOS2, CRKL, SH3GL2, SOS1, VEGFC, SHC1, SHC3, ANGPT1, EPS15, SMURF1, PDGFA, ITCH, HGF, PLCB1, HRAS, FGF19, FGF7, PHLPP1, SH3GL3, KITLG, PLCB4, FIGF, FGF22, TRAF6, CSF1, CBLB, GRB2, FGF8, EFNA1, FGF17, RNF41, STAT3, IGF1, FGF13, EPN2, FGF21, CBL, VEGFA, PHLPP2, FGF5, INS, FGF12, PDGFD, FGF9, EPN1, EGF, SH3GL1, PDGFC, SH3GLB2, NEDD4

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Signaling pathways regulating pluripotency of stem cellshsa045505.62FGFR3, FGFR2
Pathways in cancerhsa052003.982FGFR3, FGFR2
Rap1 signaling pathwayhsa040154.972FGFR3, FGFR2
Ras signaling pathwayhsa040144.92FGFR3, FGFR2
Central carbon metabolism in cancerhsa052306.72FGFR3, FGFR2
Endocytosishsa041444.922FGFR3, FGFR2
MAPK signaling pathwayhsa040104.632FGFR3, FGFR2
PI3K-Akt signaling pathwayhsa041514.212FGFR3, FGFR2
Regulation of actin cytoskeletonhsa048104.92FGFR3, FGFR2

NET-GE enrichment

Term New enriched termICP valueGenes
Melanoma (hsa05218) NEW6.560.022FGFR3, FGFR2
Central carbon metabolism in cancer (hsa05230) -6.70.006FGFR3, FGFR2
Signaling pathways regulating pluripotency of stem cells (hsa04550) -5.60.002FGFR3, FGFR2, TWIST1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
PI-3K cascade:FGFR4R-HSA-56547206.372FGFR3, FGFR2
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.852FGFR3, FGFR2
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.262FGFR3, FGFR2
NCAM signaling for neurite out-growthR-HSA-3751654.92FGFR3, FGFR2
PI3K/AKT activationR-HSA-1982036.322FGFR3, FGFR2
Signaling by InterleukinsR-HSA-4491474.712FGFR3, FGFR2
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.992FGFR3, FGFR2
Immune SystemR-HSA-1682562.372FGFR3, FGFR2
Frs2-mediated activationR-HSA-1709685.122FGFR3, FGFR2
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.622FGFR3, FGFR2
Cytokine Signaling in Immune systemR-HSA-12802153.742FGFR3, FGFR2
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.952FGFR3, FGFR2
SOS-mediated signallingR-HSA-1124125.152FGFR3, FGFR2
IGF1R signaling cascadeR-HSA-24289244.852FGFR3, FGFR2
Downstream signal transductionR-HSA-1867634.652FGFR3, FGFR2
GAB1 signalosomeR-HSA-1802926.312FGFR3, FGFR2
PIP3 activates AKT signalingR-HSA-12576046.372FGFR3, FGFR2
IRS-related events triggered by IGF1RR-HSA-24289284.852FGFR3, FGFR2
Signaling by ERBB4R-HSA-12363944.72FGFR3, FGFR2
Signaling by Insulin receptorR-HSA-747524.732FGFR3, FGFR2
Adaptive Immune SystemR-HSA-12802183.192FGFR3, FGFR2
Developmental BiologyR-HSA-12667383.482FGFR3, FGFR2
RAF/MAP kinase cascadeR-HSA-56730015.152FGFR3, FGFR2
Downstream signaling of activated FGFR1R-HSA-56546874.712FGFR3, FGFR2
MAPK family signaling cascadesR-HSA-56830574.892FGFR3, FGFR2
Signaling by LeptinR-HSA-25865525.12FGFR3, FGFR2
PI3K CascadeR-HSA-1097046.682FGFR3, FGFR2
Signaling by VEGFR-HSA-1941384.662FGFR3, FGFR2
Signalling to p38 via RIT and RINR-HSA-1877065.122FGFR3, FGFR2
PI-3K cascade:FGFR1R-HSA-56546896.372FGFR3, FGFR2
FCERI mediated MAPK activationR-HSA-28717964.322FGFR3, FGFR2
IRS-mediated signallingR-HSA-1123994.872FGFR3, FGFR2
FRS-mediated FGFR2 signalingR-HSA-56547005.142FGFR3, FGFR2
FRS-mediated FGFR4 signalingR-HSA-56547125.142FGFR3, FGFR2
FRS-mediated FGFR3 signalingR-HSA-56547065.142FGFR3, FGFR2
DiseaseR-HSA-16436853.332FGFR3, FGFR2
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.592FGFR3, FGFR2
Downstream signaling of activated FGFR3R-HSA-56547084.712FGFR3, FGFR2
Insulin receptor signalling cascadeR-HSA-747514.852FGFR3, FGFR2
Signaling by FGFR4R-HSA-56547434.692FGFR3, FGFR2
Signaling by FGFR in diseaseR-HSA-12260997.492FGFR3, FGFR2
Signaling by FGFR3R-HSA-56547414.692FGFR3, FGFR2
VEGFA-VEGFR2 PathwayR-HSA-44200974.72FGFR3, FGFR2
GRB2 events in ERBB2 signalingR-HSA-19636405.152FGFR3, FGFR2
Signaling by FGFRR-HSA-1902364.672FGFR3, FGFR2
PI3K/AKT Signaling in CancerR-HSA-22195286.562FGFR3, FGFR2
Diseases of signal transductionR-HSA-56632024.892FGFR3, FGFR2
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.032FGFR3, FGFR2
Interleukin-2 signalingR-HSA-4519275.052FGFR3, FGFR2
MAPK1/MAPK3 signalingR-HSA-56849965.112FGFR3, FGFR2
Interleukin receptor SHC signalingR-HSA-9125265.092FGFR3, FGFR2
Innate Immune SystemR-HSA-1682493.172FGFR3, FGFR2
Signaling by SCF-KITR-HSA-14335574.732FGFR3, FGFR2
Constitutive Signaling by Aberrant PI3K in CancerR-HSA-22195307.052FGFR3, FGFR2
Signaling by PDGFR-HSA-1867974.532FGFR3, FGFR2
Signalling to RASR-HSA-1670445.082FGFR3, FGFR2
PI3K events in ERBB2 signalingR-HSA-19636426.372FGFR3, FGFR2
SHC1 events in EGFR signalingR-HSA-1803365.152FGFR3, FGFR2
SHC1 events in ERBB2 signalingR-HSA-12501965.152FGFR3, FGFR2
PI-3K cascade:FGFR2R-HSA-56546956.372FGFR3, FGFR2
Downstream signaling of activated FGFR2R-HSA-56546964.712FGFR3, FGFR2
SHC1 events in ERBB4 signalingR-HSA-12503475.152FGFR3, FGFR2
Signaling by EGFRR-HSA-1779294.592FGFR3, FGFR2
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.512FGFR3, FGFR2
FRS-mediated FGFR1 signalingR-HSA-56546935.142FGFR3, FGFR2
Prolonged ERK activation eventsR-HSA-1698935.112FGFR3, FGFR2
Signalling to ERKsR-HSA-1876875.042FGFR3, FGFR2
Signalling by NGFR-HSA-1665204.232FGFR3, FGFR2
Signaling by GPCRR-HSA-3727902.682FGFR3, FGFR2
Signaling by FGFR2R-HSA-56547384.682FGFR3, FGFR2
GRB2 events in EGFR signalingR-HSA-1798125.152FGFR3, FGFR2
Signaling by FGFR1R-HSA-56547364.692FGFR3, FGFR2
PI3K events in ERBB4 signalingR-HSA-12503426.372FGFR3, FGFR2
ARMS-mediated activationR-HSA-1709845.122FGFR3, FGFR2
PI-3K cascade:FGFR3R-HSA-56547106.372FGFR3, FGFR2
DAP12 interactionsR-HSA-21721274.562FGFR3, FGFR2
Downstream signaling of activated FGFR4R-HSA-56547164.712FGFR3, FGFR2
Signaling by ERBB2R-HSA-12279864.662FGFR3, FGFR2
Axon guidanceR-HSA-4224753.932FGFR3, FGFR2
VEGFR2 mediated cell proliferationR-HSA-52189215.072FGFR3, FGFR2
Signal TransductionR-HSA-1625821.782FGFR3, FGFR2
DAP12 signalingR-HSA-24244914.642FGFR3, FGFR2

NET-GE enrichment

Term New enriched termICP valueGenes
Phospholipase C-mediated cascade; FGFR2 (R-HSA-5654221) NEW7.370.031FGFR3, FGFR2
PI3K/AKT activation (R-HSA-198203) -6.320.016FGFR3, FGFR2
Phospholipase C-mediated cascade; FGFR3 (R-HSA-5654227) NEW7.520.023FGFR3, FGFR2
FGFR2 ligand binding and activation (R-HSA-190241) NEW8.660.002FGFR3, FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530) -7.050.032FGFR3, FGFR2
PI3K events in ERBB2 signaling (R-HSA-1963642) -6.370.015FGFR3, FGFR2
GAB1 signalosome (R-HSA-180292) -6.310.016FGFR3, FGFR2
FGFR2c ligand binding and activation (R-HSA-190375) NEW9.280.001FGFR3, FGFR2
PIP3 activates AKT signaling (R-HSA-1257604) -6.370.015FGFR3, FGFR2
PI-3K cascade:FGFR3 (R-HSA-5654710) -6.370.015FGFR3, FGFR2
PI-3K cascade:FGFR4 (R-HSA-5654720) -6.370.015FGFR3, FGFR2
PI-3K cascade:FGFR1 (R-HSA-5654689) -6.370.015FGFR3, FGFR2
Negative regulation of FGFR1 signaling (R-HSA-5654726) NEW7.980.008FGFR3, FGFR2
Negative regulation of FGFR2 signaling (R-HSA-5654727) NEW7.890.008FGFR3, FGFR2
Phospholipase C-mediated cascade: FGFR1 (R-HSA-5654219) NEW7.430.032FGFR3, FGFR2
Downstream signaling events of B Cell Receptor (BCR) (R-HSA-1168372) -5.590.044FGFR3, FGFR2
FGFR1 mutant receptor activation (R-HSA-1839124) NEW8.120.011FGFR3, FGFR2
Signaling by FGFR in disease (R-HSA-1226099) -7.490.023FGFR3, FGFR2
FGFR2 mutant receptor activation (R-HSA-1839126) NEW8.890.001FGFR3, FGFR2
Activated point mutants of FGFR2 (R-HSA-2033519) NEW8.890.001FGFR3, FGFR2
PI3K/AKT Signaling in Cancer (R-HSA-2219528) -6.560.011FGFR3, FGFR2
Signaling by FGFR1 in disease (R-HSA-5655302) NEW7.810.017FGFR3, FGFR2
NCAM signaling for neurite out-growth (R-HSA-375165) -4.90.027FGFR3, FGFR2, TWIST1
SHC-mediated cascade:FGFR2 (R-HSA-5654699) NEW8.280.004FGFR3, FGFR2
PI-3K cascade:FGFR2 (R-HSA-5654695) -6.370.015FGFR3, FGFR2
PI3K events in ERBB4 signaling (R-HSA-1250342) -6.370.015FGFR3, FGFR2
Negative regulation of FGFR3 signaling (R-HSA-5654732) NEW8.120.006FGFR3, FGFR2
PI3K Cascade (R-HSA-109704) -6.680.01FGFR3, FGFR2
Signaling by FGFR2 in disease (R-HSA-5655253) NEW8.230.004FGFR3, FGFR2
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
organic cyclic compound binding (GO:0097159) 1.053FGFR3, FGFR2, TWIST1
binding (GO:0005488) 0.183FGFR3, FGFR2, TWIST1
protein binding (GO:0005515) 0.463FGFR3, FGFR2, TWIST1
heterocyclic compound binding (GO:1901363) 1.063FGFR3, FGFR2, TWIST1
Ras guanyl-nucleotide exchange factor activity (GO:0005088) 4.312FGFR3, FGFR2
signaling receptor activity (GO:0038023) 2.492FGFR3, FGFR2
signal transducer activity (GO:0004871) 2.282FGFR3, FGFR2
purine ribonucleoside triphosphate binding (GO:0035639) 2.222FGFR3, FGFR2
guanyl-nucleotide exchange factor activity (GO:0005085) 4.022FGFR3, FGFR2
molecular transducer activity (GO:0060089) 2.322FGFR3, FGFR2
receptor activity (GO:0004872) 2.322FGFR3, FGFR2
phosphatidylinositol 3-kinase activity (GO:0035004) 5.492FGFR3, FGFR2
molecular function regulator (GO:0098772) 2.512FGFR3, FGFR2
purine nucleoside binding (GO:0001883) 2.222FGFR3, FGFR2
nucleoside binding (GO:0001882) 2.212FGFR3, FGFR2
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934) 5.612FGFR3, FGFR2
carbohydrate derivative binding (GO:0097367) 2.032FGFR3, FGFR2
growth factor binding (GO:0019838) 4.892FGFR3, FGFR2
nucleotide binding (GO:0000166) 1.962FGFR3, FGFR2
phosphatidylinositol bisphosphate kinase activity (GO:0052813) 5.562FGFR3, FGFR2
transmembrane receptor protein tyrosine kinase activity (GO:0004714) 5.552FGFR3, FGFR2
ribonucleotide binding (GO:0032553) 2.192FGFR3, FGFR2
protein tyrosine kinase activity (GO:0004713) 4.542FGFR3, FGFR2
ribonucleoside binding (GO:0032549) 2.222FGFR3, FGFR2
purine nucleotide binding (GO:0017076) 2.192FGFR3, FGFR2
ATP binding (GO:0005524) 2.432FGFR3, FGFR2
protein homodimerization activity (GO:0042803) 3.162FGFR2, TWIST1
kinase activity (GO:0016301) 2.932FGFR3, FGFR2
1-phosphatidylinositol-3-kinase activity (GO:0016303) 5.982FGFR3, FGFR2
protein kinase activity (GO:0004672) 3.272FGFR3, FGFR2
nucleoside phosphate binding (GO:1901265) 1.962FGFR3, FGFR2
small molecule binding (GO:0036094) 1.892FGFR3, FGFR2
catalytic activity (GO:0003824) 1.052FGFR3, FGFR2
fibroblast growth factor binding (GO:0017134) 6.522FGFR3, FGFR2
adenyl nucleotide binding (GO:0030554) 2.42FGFR3, FGFR2
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.082FGFR3, FGFR2
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.772FGFR3, FGFR2
phosphatidylinositol kinase activity (GO:0052742) 5.812FGFR3, FGFR2
transmembrane signaling receptor activity (GO:0004888) 2.572FGFR3, FGFR2
transferase activity (GO:0016740) 1.952FGFR3, FGFR2
adenyl ribonucleotide binding (GO:0032559) 2.412FGFR3, FGFR2
identical protein binding (GO:0042802) 2.632FGFR2, TWIST1
fibroblast growth factor-activated receptor activity (GO:0005007) 8.132FGFR3, FGFR2
purine ribonucleotide binding (GO:0032555) 2.22FGFR3, FGFR2
protein dimerization activity (GO:0046983) 2.722FGFR2, TWIST1
transmembrane receptor protein kinase activity (GO:0019199) 5.322FGFR3, FGFR2
purine ribonucleoside binding (GO:0032550) 2.222FGFR3, FGFR2
transmembrane receptor activity (GO:0099600) 2.532FGFR3, FGFR2

NET-GE enrichment

Term New enriched termICP valueGenes
growth factor binding (GO:0019838) -4.890.008FGFR3, FGFR2
fibroblast growth factor binding (GO:0017134) -6.520.0FGFR3, FGFR2
transmembrane receptor protein tyrosine kinase activity (GO:0004714) -5.550.003FGFR3, FGFR2
protein tyrosine kinase activity (GO:0004713) -4.540.012FGFR3, FGFR2
fibroblast growth factor-activated receptor activity (GO:0005007) -8.130.0FGFR3, FGFR2
transmembrane receptor protein kinase activity (GO:0019199) -5.320.024FGFR3, FGFR2
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of cell proliferation (GO:0042127) 2.413FGFR3, FGFR2, TWIST1
primary metabolic process (GO:0044238) 0.693FGFR3, FGFR2, TWIST1
regulation of phosphate metabolic process (GO:0019220) 2.353FGFR3, FGFR2, TWIST1
positive regulation of metabolic process (GO:0009893) 1.743FGFR3, FGFR2, TWIST1
regulation of metabolic process (GO:0019222) 1.023FGFR3, FGFR2, TWIST1
positive regulation of cellular metabolic process (GO:0031325) 1.813FGFR3, FGFR2, TWIST1
cell differentiation (GO:0030154) 2.143FGFR3, FGFR2, TWIST1
regulation of response to stimulus (GO:0048583) 1.543FGFR3, FGFR2, TWIST1
cellular biosynthetic process (GO:0044249) 1.373FGFR3, FGFR2, TWIST1
regulation of signaling (GO:0023051) 1.723FGFR3, FGFR2, TWIST1
regulation of cell communication (GO:0010646) 1.733FGFR3, FGFR2, TWIST1
regulation of biological process (GO:0050789) 0.453FGFR3, FGFR2, TWIST1
single-organism process (GO:0044699) 0.483FGFR3, FGFR2, TWIST1
regulation of primary metabolic process (GO:0080090) 1.083FGFR3, FGFR2, TWIST1
organic substance biosynthetic process (GO:1901576) 1.343FGFR3, FGFR2, TWIST1
regulation of intracellular signal transduction (GO:1902531) 2.313FGFR3, FGFR2, TWIST1
positive regulation of macromolecule metabolic process (GO:0010604) 1.813FGFR3, FGFR2, TWIST1
cellular macromolecule metabolic process (GO:0044260) 0.933FGFR3, FGFR2, TWIST1
regulation of signal transduction (GO:0009966) 1.843FGFR3, FGFR2, TWIST1
cellular developmental process (GO:0048869) 1.823FGFR3, FGFR2, TWIST1
regulation of protein metabolic process (GO:0051246) 1.933FGFR3, FGFR2, TWIST1
organic substance metabolic process (GO:0071704) 0.633FGFR3, FGFR2, TWIST1
biological regulation (GO:0065007) 0.393FGFR3, FGFR2, TWIST1
positive regulation of molecular function (GO:0044093) 2.233FGFR3, FGFR2, TWIST1
regulation of protein modification process (GO:0031399) 2.323FGFR3, FGFR2, TWIST1
positive regulation of biological process (GO:0048518) 1.23FGFR3, FGFR2, TWIST1
negative regulation of biological process (GO:0048519) 1.333FGFR3, FGFR2, TWIST1
regulation of molecular function (GO:0065009) 1.783FGFR3, FGFR2, TWIST1
positive regulation of cell proliferation (GO:0008284) 3.013FGFR3, FGFR2, TWIST1
organ morphogenesis (GO:0009887) 3.553FGFR3, FGFR2, TWIST1
multicellular organismal process (GO:0032501) 1.453FGFR3, FGFR2, TWIST1
cell proliferation (GO:0008283) 3.233FGFR3, FGFR2, TWIST1
regulation of developmental process (GO:0050793) 2.13FGFR3, FGFR2, TWIST1
regulation of cellular metabolic process (GO:0031323) 1.073FGFR3, FGFR2, TWIST1
cellular process (GO:0009987) 0.263FGFR3, FGFR2, TWIST1
regulation of cellular process (GO:0050794) 0.53FGFR3, FGFR2, TWIST1
single-organism developmental process (GO:0044767) 1.493FGFR3, FGFR2, TWIST1
biosynthetic process (GO:0009058) 1.323FGFR3, FGFR2, TWIST1
single-organism cellular process (GO:0044763) 0.653FGFR3, FGFR2, TWIST1
metabolic process (GO:0008152) 0.583FGFR3, FGFR2, TWIST1
regulation of phosphatidylinositol 3-kinase signaling (GO:0014066) 4.793FGFR3, FGFR2, TWIST1
regulation of phosphorylation (GO:0042325) 2.53FGFR3, FGFR2, TWIST1
regulation of phosphorus metabolic process (GO:0051174) 2.353FGFR3, FGFR2, TWIST1
regulation of cellular protein metabolic process (GO:0032268) 1.993FGFR3, FGFR2, TWIST1
single-multicellular organism process (GO:0044707) 1.783FGFR3, FGFR2, TWIST1
regulation of macromolecule metabolic process (GO:0060255) 1.083FGFR3, FGFR2, TWIST1
anatomical structure development (GO:0048856) 1.583FGFR3, FGFR2, TWIST1
cellular metabolic process (GO:0044237) 0.693FGFR3, FGFR2, TWIST1
macromolecule metabolic process (GO:0043170) 0.833FGFR3, FGFR2, TWIST1
developmental process (GO:0032502) 1.363FGFR3, FGFR2, TWIST1
anatomical structure morphogenesis (GO:0009653) 2.533FGFR3, FGFR2, TWIST1
regulation of protein phosphorylation (GO:0001932) 2.573FGFR3, FGFR2, TWIST1
positive regulation of cellular process (GO:0048522) 1.33FGFR3, FGFR2, TWIST1
developmental growth (GO:0048589) 4.052FGFR3, FGFR2
positive regulation of lipase activity (GO:0060193) 5.542FGFR3, FGFR2
positive regulation of response to stimulus (GO:0048584) 2.182FGFR3, FGFR2
cell development (GO:0048468) 3.282FGFR2, TWIST1
ossification (GO:0001503) 4.862FGFR3, TWIST1
signal transduction (GO:0007165) 1.282FGFR3, FGFR2
cell surface receptor signaling pathway (GO:0007166) 2.092FGFR3, FGFR2
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242FGFR3, FGFR2
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.542FGFR3, FGFR2
signal transduction by protein phosphorylation (GO:0023014) 3.792FGFR3, FGFR2
single-organism metabolic process (GO:0044710) 1.632FGFR3, FGFR2
single-organism biosynthetic process (GO:0044711) 2.82FGFR3, FGFR2
negative regulation of macromolecule metabolic process (GO:0010605) 2.012FGFR2, TWIST1
positive regulation of signal transduction (GO:0009967) 2.52FGFR3, FGFR2
peptidyl-tyrosine modification (GO:0018212) 4.472FGFR3, FGFR2
peptidyl-amino acid modification (GO:0018193) 2.982FGFR3, FGFR2
regulation of osteoblast differentiation (GO:0045667) 4.992FGFR2, TWIST1
animal organ development (GO:0048513) 2.532FGFR2, TWIST1
positive regulation of lipid metabolic process (GO:0045834) 4.882FGFR3, TWIST1
phosphorylation (GO:0016310) 2.632FGFR3, FGFR2
phosphatidylinositol biosynthetic process (GO:0006661) 4.942FGFR3, FGFR2
regulation of striated muscle tissue development (GO:0016202) 5.092FGFR2, TWIST1
regulation of phospholipase activity (GO:0010517) 5.572FGFR3, FGFR2
phosphatidylinositol metabolic process (GO:0046488) 4.462FGFR3, FGFR2
regulation of RNA biosynthetic process (GO:2001141) 1.552FGFR2, TWIST1
glycerolipid metabolic process (GO:0046486) 3.912FGFR3, FGFR2
single organism signaling (GO:0044700) 3.252FGFR3, FGFR2
positive regulation of phosphorylation (GO:0042327) 2.92FGFR3, FGFR2
protein metabolic process (GO:0019538) 1.452FGFR3, FGFR2
organophosphate metabolic process (GO:0019637) 3.042FGFR3, FGFR2
skeletal system morphogenesis (GO:0048705) 4.982FGFR2, TWIST1
embryonic organ morphogenesis (GO:0048562) 4.922FGFR2, TWIST1
negative regulation of metabolic process (GO:0009892) 1.932FGFR2, TWIST1
negative regulation of biosynthetic process (GO:0009890) 2.472FGFR2, TWIST1
positive regulation of biosynthetic process (GO:0009891) 2.292FGFR2, TWIST1
organ growth (GO:0035265) 6.332FGFR3, FGFR2
negative regulation of gene expression (GO:0010629) 2.482FGFR2, TWIST1
positive regulation of gene expression (GO:0010628) 2.352FGFR2, TWIST1
intracellular signal transduction (GO:0035556) 2.392FGFR3, FGFR2
bone mineralization (GO:0030282) 6.092FGFR3, FGFR2
cellular protein metabolic process (GO:0044267) 1.632FGFR3, FGFR2
positive regulation of GTPase activity (GO:0043547) 3.282FGFR3, FGFR2
positive regulation of hydrolase activity (GO:0051345) 2.912FGFR3, FGFR2
regulation of GTPase activity (GO:0043087) 3.212FGFR3, FGFR2
phosphatidylinositol phosphorylation (GO:0046854) 5.192FGFR3, FGFR2
anatomical structure formation involved in morphogenesis (GO:0048646) 3.012FGFR2, TWIST1
regulation of muscle tissue development (GO:1901861) 5.072FGFR2, TWIST1
embryonic skeletal system morphogenesis (GO:0048704) 5.312FGFR2, TWIST1
embryonic cranial skeleton morphogenesis (GO:0048701) 6.22FGFR2, TWIST1
lipid metabolic process (GO:0006629) 2.682FGFR3, FGFR2
regulation of catalytic activity (GO:0050790) 1.972FGFR3, FGFR2
regulation of biosynthetic process (GO:0009889) 1.372FGFR2, TWIST1
tissue development (GO:0009888) 3.272FGFR3, FGFR2
positive regulation of MAPK cascade (GO:0043410) 3.572FGFR3, FGFR2
programmed cell death (GO:0012501) 3.12FGFR3, FGFR2
macromolecule modification (GO:0043412) 1.732FGFR3, FGFR2
protein modification process (GO:0036211) 1.792FGFR3, FGFR2
regulation of multicellular organismal process (GO:0051239) 1.872FGFR2, TWIST1
positive regulation of intracellular signal transduction (GO:1902533) 2.952FGFR3, FGFR2
regulation of ossification (GO:0030278) 4.532FGFR2, TWIST1
organophosphate biosynthetic process (GO:0090407) 3.672FGFR3, FGFR2
inositol lipid-mediated signaling (GO:0048017) 4.912FGFR3, FGFR2
regulation of hydrolase activity (GO:0051336) 2.532FGFR3, FGFR2
phospholipid biosynthetic process (GO:0008654) 4.392FGFR3, FGFR2
positive regulation of protein modification process (GO:0031401) 2.72FGFR3, FGFR2
regulation of transcription, DNA-templated (GO:0006355) 1.562FGFR2, TWIST1
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392FGFR2, TWIST1
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242FGFR2, TWIST1
positive regulation of multicellular organismal process (GO:0051240) 2.492FGFR2, TWIST1
regulation of developmental growth (GO:0048638) 4.042FGFR3, FGFR2
regulation of lipase activity (GO:0060191) 5.312FGFR3, FGFR2
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472FGFR2, TWIST1
MAPK cascade (GO:0000165) 3.912FGFR3, FGFR2
biomineral tissue development (GO:0031214) 5.412FGFR3, FGFR2
regulation of muscle organ development (GO:0048634) 5.072FGFR2, TWIST1
positive regulation of signaling (GO:0023056) 2.412FGFR3, FGFR2
embryo development (GO:0009790) 4.22FGFR2, TWIST1
embryo development ending in birth or egg hatching (GO:0009792) 4.352FGFR2, TWIST1
signaling (GO:0023052) 3.252FGFR3, FGFR2
positive regulation of cell communication (GO:0010647) 2.412FGFR3, FGFR2
fibroblast growth factor receptor signaling pathway (GO:0008543) 5.32FGFR3, FGFR2
protein autophosphorylation (GO:0046777) 4.462FGFR3, FGFR2
positive regulation of catalytic activity (GO:0043085) 2.42FGFR3, FGFR2
regulation of MAPK cascade (GO:0043408) 3.222FGFR3, FGFR2
in utero embryonic development (GO:0001701) 4.42FGFR2, TWIST1
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122FGFR2, TWIST1
phosphatidylinositol-mediated signaling (GO:0048015) 4.932FGFR3, FGFR2
positive regulation of phosphorus metabolic process (GO:0010562) 2.782FGFR3, FGFR2
regulation of anatomical structure morphogenesis (GO:0022603) 2.792FGFR2, TWIST1
positive regulation of protein metabolic process (GO:0051247) 2.432FGFR3, FGFR2
lipid phosphorylation (GO:0046834) 5.132FGFR3, FGFR2
positive regulation of cellular protein metabolic process (GO:0032270) 2.492FGFR3, FGFR2
chordate embryonic development (GO:0043009) 4.382FGFR2, TWIST1
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562FGFR2, TWIST1
phospholipid metabolic process (GO:0006644) 3.882FGFR3, FGFR2
regulation of nucleic acid-templated transcription (GO:1903506) 1.552FGFR2, TWIST1
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712FGFR2, TWIST1
regulation of cell differentiation (GO:0045595) 2.422FGFR2, TWIST1
negative regulation of transcription, DNA-templated (GO:0045892) 2.752FGFR2, TWIST1
peptidyl-tyrosine phosphorylation (GO:0018108) 4.482FGFR3, FGFR2
cellular lipid metabolic process (GO:0044255) 2.922FGFR3, FGFR2
lipid modification (GO:0030258) 4.372FGFR3, FGFR2
negative regulation of developmental process (GO:0051093) 3.172FGFR3, TWIST1
regulation of epithelial cell proliferation (GO:0050678) 4.062FGFR2, TWIST1
positive regulation of epithelial cell proliferation (GO:0050679) 4.672FGFR2, TWIST1
positive regulation of developmental process (GO:0051094) 2.772FGFR2, TWIST1
negative regulation of RNA metabolic process (GO:0051253) 2.662FGFR2, TWIST1
regulation of RNA metabolic process (GO:0051252) 1.522FGFR2, TWIST1
positive regulation of RNA metabolic process (GO:0051254) 2.512FGFR2, TWIST1
positive regulation of RNA biosynthetic process (GO:1902680) 2.542FGFR2, TWIST1
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.812FGFR2, TWIST1
glycerophospholipid biosynthetic process (GO:0046474) 4.622FGFR3, FGFR2
positive regulation of ERK1 and ERK2 cascade (GO:0070374) 4.562FGFR3, FGFR2
regulation of ERK1 and ERK2 cascade (GO:0070372) 4.232FGFR3, FGFR2
glycerophospholipid metabolic process (GO:0006650) 4.132FGFR3, FGFR2
positive regulation of cellular biosynthetic process (GO:0031328) 2.32FGFR2, TWIST1
negative regulation of cellular biosynthetic process (GO:0031327) 2.492FGFR2, TWIST1
regulation of cellular biosynthetic process (GO:0031326) 1.382FGFR2, TWIST1
negative regulation of cellular metabolic process (GO:0031324) 2.012FGFR2, TWIST1
bone morphogenesis (GO:0060349) 6.22FGFR3, FGFR2
bone development (GO:0060348) 5.822FGFR2, TWIST1
cell death (GO:0008219) 3.052FGFR3, FGFR2
multicellular organism development (GO:0007275) 2.542FGFR2, TWIST1
glycerolipid biosynthetic process (GO:0045017) 4.532FGFR3, FGFR2
growth (GO:0040007) 3.82FGFR3, FGFR2
regulation of growth (GO:0040008) 3.262FGFR3, FGFR2
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462FGFR2, TWIST1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62FGFR2, TWIST1
regulation of macromolecule biosynthetic process (GO:0010556) 1.432FGFR2, TWIST1
tissue morphogenesis (GO:0048729) 3.872FGFR2, TWIST1
regulation of gene expression (GO:0010468) 1.372FGFR2, TWIST1
embryonic morphogenesis (GO:0048598) 3.722FGFR2, TWIST1
protein phosphorylation (GO:0006468) 2.892FGFR3, FGFR2
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352FGFR2, TWIST1
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.552FGFR2, TWIST1
positive regulation of phosphate metabolic process (GO:0045937) 2.782FGFR3, FGFR2
regulation of lipid metabolic process (GO:0019216) 4.082FGFR3, TWIST1
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432FGFR2, TWIST1
apoptotic process (GO:0006915) 3.142FGFR3, FGFR2
cellular protein modification process (GO:0006464) 1.792FGFR3, FGFR2
negative regulation of RNA biosynthetic process (GO:1902679) 2.72FGFR2, TWIST1
regulation of nitrogen compound metabolic process (GO:0051171) 1.362FGFR2, TWIST1
phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) 5.842FGFR3, FGFR2
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292FGFR2, TWIST1
cell-cell signaling (GO:0007267) 3.352FGFR3, FGFR2
cell communication (GO:0007154) 3.042FGFR3, FGFR2
lipid biosynthetic process (GO:0008610) 3.492FGFR3, FGFR2
odontogenesis (GO:0042476) 5.192FGFR2, TWIST1
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532FGFR2, TWIST1
positive regulation of phospholipase activity (GO:0010518) 5.762FGFR3, FGFR2
phosphate-containing compound metabolic process (GO:0006796) 2.162FGFR3, FGFR2
regulation of multicellular organismal development (GO:2000026) 2.312FGFR2, TWIST1
regulation of organ morphogenesis (GO:2000027) 4.222FGFR2, TWIST1
phosphorus metabolic process (GO:0006793) 2.152FGFR3, FGFR2
positive regulation of protein phosphorylation (GO:0001934) 2.952FGFR3, FGFR2
negative regulation of cellular process (GO:0048523) 1.412FGFR2, TWIST1
positive regulation of transcription, DNA-templated (GO:0045893) 2.562FGFR2, TWIST1

NET-GE enrichment

Term New enriched termICP valueGenes
positive regulation of lipase activity (GO:0060193) -5.540.045FGFR3, FGFR2
regulation of smoothened signaling pathway (GO:0008589) NEW5.620.024FGFR3, FGFR2
developmental growth (GO:0048589) -4.050.025FGFR3, FGFR2, TWIST1
regulation of organelle organization (GO:0033043) NEW2.720.045FGFR3, FGFR2, TWIST1
positive regulation of canonical Wnt signaling pathway (GO:0090263) NEW4.950.02FGFR3, FGFR2
craniofacial suture morphogenesis (GO:0097094) NEW7.090.009FGFR2, TWIST1
cranial suture morphogenesis (GO:0060363) NEW7.530.002FGFR2, TWIST1
positive regulation of Wnt signaling pathway (GO:0030177) NEW4.70.043FGFR3, FGFR2
inner ear receptor cell differentiation (GO:0060113) NEW7.020.007FGFR3, FGFR2
bone mineralization (GO:0030282) -6.090.009FGFR3, FGFR2
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) -3.120.026FGFR3, FGFR2, TWIST1
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway (GO:0090080) NEW8.120.0FGFR3, FGFR2
response to growth factor (GO:0070848) NEW4.140.021FGFR3, FGFR2, TWIST1
negative regulation of cellular component organization (GO:0051129) NEW3.350.011FGFR3, FGFR2, TWIST1
tissue morphogenesis (GO:0048729) -3.870.005FGFR3, FGFR2, TWIST1
negative regulation of mitosis (GO:0045839) NEW6.260.011FGFR3, FGFR2
developmental growth involved in morphogenesis (GO:0060560) NEW5.150.035FGFR3, FGFR2
positive regulation of cell proliferation (GO:0008284) -3.010.049FGFR3, FGFR2, TWIST1
embryonic skeletal system morphogenesis (GO:0048704) -5.310.04FGFR2, TWIST1
embryonic cranial skeleton morphogenesis (GO:0048701) -6.20.039FGFR2, TWIST1
mesenchymal cell proliferation (GO:0010463) NEW7.160.002FGFR3, FGFR2
cell proliferation (GO:0008283) -3.230.026FGFR3, FGFR2, TWIST1
lens fiber cell development (GO:0070307) NEW7.530.003FGFR3, FGFR2
bone morphogenesis (GO:0060349) -6.20.004FGFR3, FGFR2
biomineral tissue development (GO:0031214) -5.410.03FGFR3, FGFR2
mesenchyme development (GO:0060485) NEW5.70.0FGFR3, FGFR2, TWIST1
replacement ossification (GO:0036075) NEW6.470.038FGFR3, FGFR2
cellular response to growth factor stimulus (GO:0071363) NEW4.270.019FGFR3, FGFR2, TWIST1
positive regulation of epithelial cell proliferation (GO:0050679) -4.670.0FGFR3, FGFR2, TWIST1
endochondral ossification (GO:0001958) NEW6.470.038FGFR3, FGFR2
regulation of epithelial cell proliferation (GO:0050678) -4.060.002FGFR3, FGFR2, TWIST1
negative regulation of organelle organization (GO:0010639) NEW4.070.001FGFR3, FGFR2, TWIST1
positive regulation of phospholipase activity (GO:0010518) -5.760.036FGFR3, FGFR2
negative regulation of nuclear division (GO:0051784) NEW5.940.017FGFR3, FGFR2
stem cell proliferation (GO:0072089) NEW6.070.0FGFR3, FGFR2, TWIST1
digestive tract morphogenesis (GO:0048546) NEW6.780.015FGFR3, FGFR2
regulation of phospholipase activity (GO:0010517) -5.570.045FGFR3, FGFR2
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.63FGFR3, FGFR2, TWIST1
nucleus (GO:0005634) 1.073FGFR3, FGFR2, TWIST1
cell part (GO:0044464) 0.113FGFR3, FGFR2, TWIST1
intracellular organelle (GO:0043229) 0.513FGFR3, FGFR2, TWIST1
intracellular part (GO:0044424) 0.283FGFR3, FGFR2, TWIST1
membrane-bounded organelle (GO:0043227) 0.473FGFR3, FGFR2, TWIST1
organelle (GO:0043226) 0.43FGFR3, FGFR2, TWIST1
cytoplasm (GO:0005737) 1.012FGFR3, FGFR2
Golgi apparatus (GO:0005794) 2.72FGFR3, FGFR2
vesicle (GO:0031982) 1.642FGFR3, FGFR2
plasma membrane part (GO:0044459) 1.952FGFR3, FGFR2
cytoplasmic, membrane-bounded vesicle (GO:0016023) 3.122FGFR3, FGFR2
cytoplasmic vesicle (GO:0031410) 2.872FGFR3, FGFR2
cell surface (GO:0009986) 3.442FGFR3, FGFR2
membrane (GO:0016020) 0.682FGFR3, FGFR2
membrane-bounded vesicle (GO:0031988) 1.712FGFR3, FGFR2
cytoplasmic part (GO:0044444) 0.822FGFR3, FGFR2
extracellular region (GO:0005576) 2.182FGFR3, FGFR2
intracellular vesicle (GO:0097708) 2.862FGFR3, FGFR2
integral component of plasma membrane (GO:0005887) 2.572FGFR3, FGFR2
plasma membrane (GO:0005886) 1.392FGFR3, FGFR2
membrane part (GO:0044425) 0.952FGFR3, FGFR2
intrinsic component of plasma membrane (GO:0031226) 2.532FGFR3, FGFR2
integral component of membrane (GO:0016021) 1.142FGFR3, FGFR2
intrinsic component of membrane (GO:0031224) 1.132FGFR3, FGFR2