Disease table of KERATOSIS, SEBORRHEIC OMIM ID: 182000

Gene-disease associations table

GeneAssociated with KERATOSIS, SEBORRHEIC inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
PIK3CAOMIM, HUMSAVARHGNC link3q26.3211114550, PS158350, 167000, 612918, 211980, 114480, 602501, 114500, 182000, 162900, 613659
FGFR3HUMSAVARHGNC link4p16.316603956, 109800, 149730, 101400, 100800, 610474, 182000, 162900, 612247, 146000, 602849, 114500, 273300, 187600, 187601, 616482

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
PIK3CAYES1FOXO30
FGFR3YES5SP1, SP3, SP4, STAT1, SHOX0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
PIK3CAFGFR3No1GRB2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
PIK3CAFGFR3No-25FIGF, IRS1, PGF, PDGFB, ANGPT2, CRKL, ANGPT1, KITLG, CRK, SOS1, CBLB, SHC1, PDGFA, HGF, HRAS, GRB2, VEGFA, VEGFC, STAT3, CBL, CBLC, INS, IGF1, EGF, EFNA1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Signaling pathways regulating pluripotency of stem cellshsa045505.62FGFR3, PIK3CA
MicroRNAs in cancerhsa052065.382FGFR3, PIK3CA
Pathways in cancerhsa052003.982FGFR3, PIK3CA
Rap1 signaling pathwayhsa040154.972FGFR3, PIK3CA
Ras signaling pathwayhsa040144.92FGFR3, PIK3CA
Central carbon metabolism in cancerhsa052306.72FGFR3, PIK3CA
PI3K-Akt signaling pathwayhsa041514.212FGFR3, PIK3CA
Regulation of actin cytoskeletonhsa048104.92FGFR3, PIK3CA

NET-GE enrichment

Term New enriched termICP valueGenes
Melanoma (hsa05218) NEW6.560.023FGFR3, PIK3CA
Central carbon metabolism in cancer (hsa05230) -6.70.015FGFR3, PIK3CA
Signaling pathways regulating pluripotency of stem cells (hsa04550) -5.60.042FGFR3, PIK3CA
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.852FGFR3, PIK3CA
PI3K/AKT activationR-HSA-1982036.322FGFR3, PIK3CA
Signaling by FGFR3 in diseaseR-HSA-56553328.522FGFR3, PIK3CA
Signaling by InterleukinsR-HSA-4491474.712FGFR3, PIK3CA
Immune SystemR-HSA-1682562.372FGFR3, PIK3CA
Constitutive Signaling by Aberrant PI3K in CancerR-HSA-22195307.052FGFR3, PIK3CA
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.622FGFR3, PIK3CA
Cytokine Signaling in Immune systemR-HSA-12802153.742FGFR3, PIK3CA
IGF1R signaling cascadeR-HSA-24289244.852FGFR3, PIK3CA
Downstream signal transductionR-HSA-1867634.652FGFR3, PIK3CA
GAB1 signalosomeR-HSA-1802926.312FGFR3, PIK3CA
IRS-related events triggered by IGF1RR-HSA-24289284.852FGFR3, PIK3CA
Signaling by ERBB4R-HSA-12363944.72FGFR3, PIK3CA
Signaling by Insulin receptorR-HSA-747524.732FGFR3, PIK3CA
Adaptive Immune SystemR-HSA-12802183.192FGFR3, PIK3CA
DiseaseR-HSA-16436853.332FGFR3, PIK3CA
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.952FGFR3, PIK3CA
Downstream signaling of activated FGFR1R-HSA-56546874.712FGFR3, PIK3CA
Signalling by NGFR-HSA-1665204.232FGFR3, PIK3CA
PI3K CascadeR-HSA-1097046.682FGFR3, PIK3CA
Signaling by VEGFR-HSA-1941384.662FGFR3, PIK3CA
PI-3K cascade:FGFR1R-HSA-56546896.372FGFR3, PIK3CA
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.262FGFR3, PIK3CA
IRS-mediated signallingR-HSA-1123994.872FGFR3, PIK3CA
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.592FGFR3, PIK3CA
Downstream signaling of activated FGFR3R-HSA-56547084.712FGFR3, PIK3CA
Insulin receptor signalling cascadeR-HSA-747514.852FGFR3, PIK3CA
Signaling by FGFR4R-HSA-56547434.692FGFR3, PIK3CA
Signaling by FGFR in diseaseR-HSA-12260997.492FGFR3, PIK3CA
Signaling by FGFR3R-HSA-56547414.692FGFR3, PIK3CA
VEGFA-VEGFR2 PathwayR-HSA-44200974.72FGFR3, PIK3CA
Signaling by FGFRR-HSA-1902364.672FGFR3, PIK3CA
PI3K/AKT Signaling in CancerR-HSA-22195286.562FGFR3, PIK3CA
Diseases of signal transductionR-HSA-56632024.892FGFR3, PIK3CA
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.032FGFR3, PIK3CA
Interleukin-2 signalingR-HSA-4519275.052FGFR3, PIK3CA
Interleukin receptor SHC signalingR-HSA-9125265.092FGFR3, PIK3CA
Innate Immune SystemR-HSA-1682493.172FGFR3, PIK3CA
Signaling by SCF-KITR-HSA-14335574.732FGFR3, PIK3CA
PI-3K cascade:FGFR4R-HSA-56547206.372FGFR3, PIK3CA
Signaling by PDGFR-HSA-1867974.532FGFR3, PIK3CA
PI3K events in ERBB2 signalingR-HSA-19636426.372FGFR3, PIK3CA
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.992FGFR3, PIK3CA
PI-3K cascade:FGFR2R-HSA-56546956.372FGFR3, PIK3CA
Downstream signaling of activated FGFR2R-HSA-56546964.712FGFR3, PIK3CA
Signaling by EGFRR-HSA-1779294.592FGFR3, PIK3CA
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.512FGFR3, PIK3CA
PIP3 activates AKT signalingR-HSA-12576046.372FGFR3, PIK3CA
Signaling by GPCRR-HSA-3727902.682FGFR3, PIK3CA
Signaling by FGFR2R-HSA-56547384.682FGFR3, PIK3CA
Signaling by FGFR1R-HSA-56547364.692FGFR3, PIK3CA
PI3K events in ERBB4 signalingR-HSA-12503426.372FGFR3, PIK3CA
PI-3K cascade:FGFR3R-HSA-56547106.372FGFR3, PIK3CA
DAP12 interactionsR-HSA-21721274.562FGFR3, PIK3CA
Downstream signaling of activated FGFR4R-HSA-56547164.712FGFR3, PIK3CA
Signaling by ERBB2R-HSA-12279864.662FGFR3, PIK3CA
Signal TransductionR-HSA-1625821.782FGFR3, PIK3CA
DAP12 signalingR-HSA-24244914.642FGFR3, PIK3CA

NET-GE enrichment

Term New enriched termICP valueGenes
PI3K/AKT activation (R-HSA-198203) -6.320.02FGFR3, PIK3CA
Signaling by FGFR3 in disease (R-HSA-5655332) -8.520.001FGFR3, PIK3CA
PI-3K cascade:FGFR3 (R-HSA-5654710) -6.370.019FGFR3, PIK3CA
PI-3K cascade:FGFR4 (R-HSA-5654720) -6.370.019FGFR3, PIK3CA
PI-3K cascade:FGFR1 (R-HSA-5654689) -6.370.019FGFR3, PIK3CA
PI3K events in ERBB4 signaling (R-HSA-1250342) -6.370.019FGFR3, PIK3CA
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530) -7.050.014FGFR3, PIK3CA
PI3K events in ERBB2 signaling (R-HSA-1963642) -6.370.019FGFR3, PIK3CA
Signaling by FGFR1 in disease (R-HSA-5655302) NEW7.810.007FGFR3, PIK3CA
PI3K Cascade (R-HSA-109704) -6.680.033FGFR3, PIK3CA
PI3K/AKT Signaling in Cancer (R-HSA-2219528) -6.560.014FGFR3, PIK3CA
GAB1 signalosome (R-HSA-180292) -6.310.02FGFR3, PIK3CA
PIP3 activates AKT signaling (R-HSA-1257604) -6.370.019FGFR3, PIK3CA
PI-3K cascade:FGFR2 (R-HSA-5654695) -6.370.019FGFR3, PIK3CA
Signaling by FGFR2 in disease (R-HSA-5655253) NEW8.230.002FGFR3, PIK3CA
FGFR1 mutant receptor activation (R-HSA-1839124) NEW8.120.005FGFR3, PIK3CA
Signaling by FGFR in disease (R-HSA-1226099) -7.490.004FGFR3, PIK3CA
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
purine ribonucleoside triphosphate binding (GO:0035639) 2.222FGFR3, PIK3CA
binding (GO:0005488) 0.182FGFR3, PIK3CA
phosphatidylinositol 3-kinase activity (GO:0035004) 5.492FGFR3, PIK3CA
molecular function regulator (GO:0098772) 2.512FGFR3, PIK3CA
heterocyclic compound binding (GO:1901363) 1.062FGFR3, PIK3CA
purine nucleoside binding (GO:0001883) 2.222FGFR3, PIK3CA
nucleoside binding (GO:0001882) 2.212FGFR3, PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934) 5.612FGFR3, PIK3CA
carbohydrate derivative binding (GO:0097367) 2.032FGFR3, PIK3CA
ribonucleoside binding (GO:0032549) 2.222FGFR3, PIK3CA
nucleotide binding (GO:0000166) 1.962FGFR3, PIK3CA
phosphatidylinositol bisphosphate kinase activity (GO:0052813) 5.562FGFR3, PIK3CA
transferase activity (GO:0016740) 1.952FGFR3, PIK3CA
nucleoside phosphate binding (GO:1901265) 1.962FGFR3, PIK3CA
protein kinase activity (GO:0004672) 3.272FGFR3, PIK3CA
purine nucleotide binding (GO:0017076) 2.192FGFR3, PIK3CA
ATP binding (GO:0005524) 2.432FGFR3, PIK3CA
1-phosphatidylinositol-3-kinase activity (GO:0016303) 5.982FGFR3, PIK3CA
kinase activity (GO:0016301) 2.932FGFR3, PIK3CA
small molecule binding (GO:0036094) 1.892FGFR3, PIK3CA
catalytic activity (GO:0003824) 1.052FGFR3, PIK3CA
adenyl nucleotide binding (GO:0030554) 2.42FGFR3, PIK3CA
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.082FGFR3, PIK3CA
organic cyclic compound binding (GO:0097159) 1.052FGFR3, PIK3CA
phosphatidylinositol kinase activity (GO:0052742) 5.812FGFR3, PIK3CA
adenyl ribonucleotide binding (GO:0032559) 2.412FGFR3, PIK3CA
protein binding (GO:0005515) 0.462FGFR3, PIK3CA
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.772FGFR3, PIK3CA
purine ribonucleotide binding (GO:0032555) 2.22FGFR3, PIK3CA
purine ribonucleoside binding (GO:0032550) 2.222FGFR3, PIK3CA
ribonucleotide binding (GO:0032553) 2.192FGFR3, PIK3CA

NET-GE enrichment

Term New enriched termICP valueGenes
growth factor receptor binding (GO:0070851) NEW4.870.029FGFR3, PIK3CA
receptor signaling protein activity (GO:0005057) NEW4.760.038FGFR3, PIK3CA
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of phosphate metabolic process (GO:0019220) 2.352FGFR3, PIK3CA
regulation of primary metabolic process (GO:0080090) 1.082FGFR3, PIK3CA
regulation of metabolic process (GO:0019222) 1.022FGFR3, PIK3CA
positive regulation of response to stimulus (GO:0048584) 2.182FGFR3, PIK3CA
regulation of response to stimulus (GO:0048583) 1.542FGFR3, PIK3CA
signal transduction (GO:0007165) 1.282FGFR3, PIK3CA
cell surface receptor signaling pathway (GO:0007166) 2.092FGFR3, PIK3CA
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242FGFR3, PIK3CA
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.542FGFR3, PIK3CA
single-organism metabolic process (GO:0044710) 1.632FGFR3, PIK3CA
single-organism biosynthetic process (GO:0044711) 2.82FGFR3, PIK3CA
positive regulation of macromolecule metabolic process (GO:0010604) 1.812FGFR3, PIK3CA
regulation of signal transduction (GO:0009966) 1.842FGFR3, PIK3CA
positive regulation of molecular function (GO:0044093) 2.232FGFR3, PIK3CA
positive regulation of biological process (GO:0048518) 1.22FGFR3, PIK3CA
phosphatidylinositol biosynthetic process (GO:0006661) 4.942FGFR3, PIK3CA
regulation of macromolecule metabolic process (GO:0060255) 1.082FGFR3, PIK3CA
phosphatidylinositol metabolic process (GO:0046488) 4.462FGFR3, PIK3CA
glycerolipid metabolic process (GO:0046486) 3.912FGFR3, PIK3CA
regulation of phosphorylation (GO:0042325) 2.52FGFR3, PIK3CA
positive regulation of phosphorylation (GO:0042327) 2.92FGFR3, PIK3CA
single-multicellular organism process (GO:0044707) 1.782FGFR3, PIK3CA
protein metabolic process (GO:0019538) 1.452FGFR3, PIK3CA
organophosphate metabolic process (GO:0019637) 3.042FGFR3, PIK3CA
positive regulation of metabolic process (GO:0009893) 1.742FGFR3, PIK3CA
positive regulation of kinase activity (GO:0033674) 3.542FGFR3, PIK3CA
intracellular signal transduction (GO:0035556) 2.392FGFR3, PIK3CA
regulation of biological process (GO:0050789) 0.452FGFR3, PIK3CA
cellular protein metabolic process (GO:0044267) 1.632FGFR3, PIK3CA
positive regulation of transferase activity (GO:0051347) 3.312FGFR3, PIK3CA
cellular macromolecule metabolic process (GO:0044260) 0.932FGFR3, PIK3CA
regulation of kinase activity (GO:0043549) 3.072FGFR3, PIK3CA
biological regulation (GO:0065007) 0.392FGFR3, PIK3CA
single-organism process (GO:0044699) 0.482FGFR3, PIK3CA
phosphatidylinositol phosphorylation (GO:0046854) 5.192FGFR3, PIK3CA
regulation of molecular function (GO:0065009) 1.782FGFR3, PIK3CA
lipid metabolic process (GO:0006629) 2.682FGFR3, PIK3CA
regulation of developmental process (GO:0050793) 2.12FGFR3, PIK3CA
regulation of catalytic activity (GO:0050790) 1.972FGFR3, PIK3CA
tissue development (GO:0009888) 3.272FGFR3, PIK3CA
regulation of cellular process (GO:0050794) 0.52FGFR3, PIK3CA
macromolecule modification (GO:0043412) 1.732FGFR3, PIK3CA
protein modification process (GO:0036211) 1.792FGFR3, PIK3CA
metabolic process (GO:0008152) 0.582FGFR3, PIK3CA
system development (GO:0048731) 2.922FGFR3, PIK3CA
regulation of intracellular signal transduction (GO:1902531) 2.312FGFR3, PIK3CA
phosphatidylinositol-mediated signaling (GO:0048015) 4.932FGFR3, PIK3CA
inositol lipid-mediated signaling (GO:0048017) 4.912FGFR3, PIK3CA
single-organism developmental process (GO:0044767) 1.492FGFR3, PIK3CA
phospholipid biosynthetic process (GO:0008654) 4.392FGFR3, PIK3CA
positive regulation of protein modification process (GO:0031401) 2.72FGFR3, PIK3CA
regulation of transferase activity (GO:0051338) 2.882FGFR3, PIK3CA
regulation of developmental growth (GO:0048638) 4.042FGFR3, PIK3CA
phosphorylation (GO:0016310) 2.632FGFR3, PIK3CA
cellular biosynthetic process (GO:0044249) 1.372FGFR3, PIK3CA
regulation of signaling (GO:0023051) 1.722FGFR3, PIK3CA
regulation of cell communication (GO:0010646) 1.732FGFR3, PIK3CA
positive regulation of catalytic activity (GO:0043085) 2.42FGFR3, PIK3CA
organophosphate biosynthetic process (GO:0090407) 3.672FGFR3, PIK3CA
positive regulation of phosphorus metabolic process (GO:0010562) 2.782FGFR3, PIK3CA
regulation of protein metabolic process (GO:0051246) 1.932FGFR3, PIK3CA
positive regulation of protein metabolic process (GO:0051247) 2.432FGFR3, PIK3CA
lipid phosphorylation (GO:0046834) 5.132FGFR3, PIK3CA
positive regulation of cellular protein metabolic process (GO:0032270) 2.492FGFR3, PIK3CA
regulation of protein modification process (GO:0031399) 2.322FGFR3, PIK3CA
developmental process (GO:0032502) 1.362FGFR3, PIK3CA
phospholipid metabolic process (GO:0006644) 3.882FGFR3, PIK3CA
multicellular organismal process (GO:0032501) 1.452FGFR3, PIK3CA
cellular process (GO:0009987) 0.262FGFR3, PIK3CA
negative regulation of biological process (GO:0048519) 1.332FGFR3, PIK3CA
cellular lipid metabolic process (GO:0044255) 2.922FGFR3, PIK3CA
regulation of phosphatidylinositol 3-kinase signaling (GO:0014066) 4.792FGFR3, PIK3CA
lipid modification (GO:0030258) 4.372FGFR3, PIK3CA
regulation of cellular protein metabolic process (GO:0032268) 1.992FGFR3, PIK3CA
macromolecule metabolic process (GO:0043170) 0.832FGFR3, PIK3CA
glycerophospholipid biosynthetic process (GO:0046474) 4.622FGFR3, PIK3CA
glycerophospholipid metabolic process (GO:0006650) 4.132FGFR3, PIK3CA
positive regulation of cellular metabolic process (GO:0031325) 1.812FGFR3, PIK3CA
regulation of cellular metabolic process (GO:0031323) 1.072FGFR3, PIK3CA
glycerolipid biosynthetic process (GO:0045017) 4.532FGFR3, PIK3CA
regulation of growth (GO:0040008) 3.262FGFR3, PIK3CA
organic substance metabolic process (GO:0071704) 0.632FGFR3, PIK3CA
protein phosphorylation (GO:0006468) 2.892FGFR3, PIK3CA
positive regulation of phosphate metabolic process (GO:0045937) 2.782FGFR3, PIK3CA
organic substance biosynthetic process (GO:1901576) 1.342FGFR3, PIK3CA
cellular protein modification process (GO:0006464) 1.792FGFR3, PIK3CA
regulation of phosphorus metabolic process (GO:0051174) 2.352FGFR3, PIK3CA
biosynthetic process (GO:0009058) 1.322FGFR3, PIK3CA
single-organism cellular process (GO:0044763) 0.652FGFR3, PIK3CA
phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) 5.842FGFR3, PIK3CA
lipid biosynthetic process (GO:0008610) 3.492FGFR3, PIK3CA
primary metabolic process (GO:0044238) 0.692FGFR3, PIK3CA
anatomical structure development (GO:0048856) 1.582FGFR3, PIK3CA
cellular metabolic process (GO:0044237) 0.692FGFR3, PIK3CA
phosphate-containing compound metabolic process (GO:0006796) 2.162FGFR3, PIK3CA
phosphorus metabolic process (GO:0006793) 2.152FGFR3, PIK3CA
regulation of protein phosphorylation (GO:0001932) 2.572FGFR3, PIK3CA
positive regulation of protein phosphorylation (GO:0001934) 2.952FGFR3, PIK3CA
positive regulation of cellular process (GO:0048522) 1.32FGFR3, PIK3CA

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of phosphatidylinositol 3-kinase activity (GO:0043551) NEW6.020.01FGFR3, PIK3CA
regulation of lipid kinase activity (GO:0043550) NEW5.840.017FGFR3, PIK3CA
insulin receptor signaling pathway (GO:0008286) NEW5.330.026FGFR3, PIK3CA
positive regulation of JAK-STAT cascade (GO:0046427) NEW5.440.038FGFR3, PIK3CA
regulation of tyrosine phosphorylation of STAT protein (GO:0042509) NEW5.490.035FGFR3, PIK3CA
phosphatidylinositol-mediated signaling (GO:0048015) -4.930.022FGFR3, PIK3CA
positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531) NEW5.630.024FGFR3, PIK3CA
cellular response to fibroblast growth factor stimulus (GO:0044344) NEW6.40.04FGFR3, PIK3CA
response to fibroblast growth factor (GO:0071774) NEW6.170.041FGFR3, PIK3CA
regulation of neuron apoptotic process (GO:0043523) NEW4.470.043FGFR3, PIK3CA
epidermal growth factor receptor signaling pathway (GO:0007173) NEW5.720.043FGFR3, PIK3CA
ERBB signaling pathway (GO:0038127) NEW5.360.044FGFR3, PIK3CA
cellular response to insulin stimulus (GO:0032869) NEW5.290.044FGFR3, PIK3CA
fibroblast growth factor receptor signaling pathway (GO:0008543) NEW5.30.032FGFR3, PIK3CA
inositol lipid-mediated signaling (GO:0048017) -4.910.022FGFR3, PIK3CA
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
membrane (GO:0016020) 0.682FGFR3, PIK3CA
cell part (GO:0044464) 0.112FGFR3, PIK3CA
cytoplasmic part (GO:0044444) 0.822FGFR3, PIK3CA
plasma membrane (GO:0005886) 1.392FGFR3, PIK3CA
intracellular part (GO:0044424) 0.282FGFR3, PIK3CA
membrane part (GO:0044425) 0.952FGFR3, PIK3CA