Disease table of OVARIAN CANCER OMIM ID: 167000

Gene-disease associations table

GeneAssociated with OVARIAN CANCER inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
BRCA1HUMSAVARHGNC link17q21.315PS227650, 167000, 614320, PS604370, 114480
PIK3CAOMIM, HUMSAVARHGNC link3q26.3211114550, PS158350, 167000, 612918, 211980, 114480, 602501, 114500, 182000, 162900, 613659
RRAS2OMIMHGNC link11p15.21167000
PARK2OMIMHGNC link6q264PS168600, 167000, 607572, 211980
CTNNB1OMIM, HUMSAVARHGNC link3p22.16114550, 155255, 167000, PS156200, 114500, 132600
AKT1OMIMHGNC link14q32.336167000, 176920, 114480, 181500, 114500, PS158350
SEPT9OMIMHGNC link17q25.32167000, 162100
CDH1OMIMHGNC link16q22.15608089, 167000, 176807, 137215, 114480
OPCMLOMIM, HUMSAVARHGNC link11q251167000

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
17q22BRCA1, SEPT9
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
17q2BRCA1, SEPT9
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
112RRAS2, OPCML
172BRCA1, SEPT9
32PIK3CA, CTNNB1
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
BRCA1YES52ATM, RNASEL, DDIT3, KRT5, JAK2, MAD2L1, IRF7, EGFR, HSPA5, FOS, XPC, STAT2, EGR1, CCND1, AREG, FST, HNRNPA2B1, STAT1, CASR, E2F6, ESR1, SIRT1, DDB2, CDKN1A, KRT18, CXCL1, FOXC1, FOXC2, IFNA1, CDH3, CYP1A1, CTSD, IGF1, KHSRP, CYP19A1, HMGA2, EP300, KRT17, TFF1, STAT3, BRCA2, ASPM, TP63, IGF1R, GADD45A, JAK1, CDKN1B, CCNB1, MYC, VEGFA, IRF9, HIF1A0
CTNNB1YES20PTGS2, BIRC5, PPARD, CHGA, TCF7, CLDN2, CCND1, GLCE, CD44, GLI2, NRCAM, RB1, MMP14, JUN, SPP1, VIM, MYC, PLD1, MMP7, STARD70
RELANO302NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC62AKT1, CDH1
SIRT1NO43ACAN, TBX3, ESRRG, EZH2, CFLAR, NR1I2, FOXO3, SELE, HSF1, ABCB1, TP73, CCND1, NR5A2, CFH, HYOU1, IL1B, SHC1, COL1A2, NBN, CDKN1A, CTNNB1, MCL1, TNFRSF10B, BCL11A, CDH1, PARP1, ICAM1, PAX6, DLL4, SIRT6, NOTCH1, WRN, ADAMTS5, NDRG1, PER1, TNF, MMP9, COL10A1, TP53, EGLN1, MYC, PPARG, HIF1A2CDH1, CTNNB1
TP53NO159ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING13BRCA1, AKT1, CTNNB1
ESR1NO68UGT2B15, AR, PELP1, EGFR, FLT1, RET, AVP, NRF1, CDK4, SERPINE1, PGR, FOS, VEGFA, CHAT, RUNX2, ZFHX3, CYP19A1, SERPINB9, TYMS, DCT, CXCL12, PTMA, HTRA2, NR5A2, CD24, HSPB1, CYP1B1, CTNNB1, MMP13, BRCA1, CYP2C19, BLM, OXT, TAC3, CCNA2, ZEB1, CDKN1A, STAT5A, TERT, MDM2, PMAIP1, CYP1A1, RARA, TP53, JUN, CDH1, AMH, CRHBP, MYC, TFF1, E2F1, CRH, KDR, BTG2, BCL2, UGT1A4, TGFA, KRT19, F12, FOXP1, ESRRA, GREB1, CTSD, JUNB, ESR1, YWHAQ, CCND1, CDKN1B3BRCA1, CDH1, CTNNB1
STAT3NO129IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP122AKT1, CDH1
NFKB1NO306NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC62AKT1, CDH1
HMGA1NO17PTGS2, SP1, CXCL1, XPA, POU1F1, INSR, CRYAB, CDC25A, TWIST1, IL1B, CDH1, CD44, TP53, RAG2, SLC2A3, BRCA1, KL2BRCA1, CDH1
EZH2NO31PCNA, SFRP1, ADRB2, TWIST1, SNAI2, CDKN2B, CDKN2A, APC, RUNX3, PIP5K1C, CCNE1, DACT3, HOXB13, ALDH1A1, BRCA1, FOXC1, CDKN1A, VDR, HDAC1, RPLP0, CDH1, SATB1, TP53, AXL, ADAMTS1, SSTR1, FBXO32, MMP2, PEBP1, CIITA, CCND12BRCA1, CDH1
RB1NO29CDK1, DDIT3, BIRC5, MAP3K5, EBNA1BP2, DNMT3A, FOS, SFTPD, SP1, DHFR, HBP1, BRCA1, CDKN1A, RBL1, TFDP1, CDH1, ATF2, PCNA, E2F2, ELF1, E2F1, WRN, FGFR1, TP53BP2, RB1, IGF1, MYC, PPARG, E2F32BRCA1, CDH1
MTA1NO20EPHA2, NOS2, MMP9, EGFR, MNAT1, MTA3, SNAI1, SMAD7, BCL2L1, CDH1, MYC, CDKN1A, SNAI2, PTEN, ITGB3BP, ESR1, CDKN2A, SUMO2, BRCA1, TFF12BRCA1, CDH1
ARNO83UGT2B15, PTPN1, CDH11, AKR1C3, USP26, FOLH1, CCR2, CDK20, CDK6, PNRC1, ARG1, XIAP, VIM, ARG2, EGFR, CFLAR, ETV1, BSG, IGF1R, MUC1, WEE1, PTGS2, NKX3-1, AKT1, NRAS, CDH1, EP300, KLF5, ACTA1, CLK3, FN1, TNF, PRL, ERBB2, ERBB3, CRISP3, CTNNB1, PTEN, CRISP1, SERPINB5, TSC2, NAT1, CDKN1A, GREB1, SEPT7, IFI16, PIGR, KLK3, PC, STIM1, SRD5A3, TCF7L2, JUN, TMPRSS2, RELA, TJP1, BTG1, VEGFA, NFKB1, HMMR, FKBP5, KLK4, CRH, CDH2, BTG2, TGFA, SESN1, CDC6, TH, ALDH1A3, KISS1, KISS1R, PEBP1, KLK2, ATAD2, HMOX1, TSC1, WNT7B, PEG10, TRPS1, CCND1, PIP, FOXA13CDH1, AKT1, CTNNB1
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
BRCA1YES33WWP1, RBL2, EZH2, DLX4, CTBP1, SP1, E2F4, ID4, NCOA3, USF2, MTA1, E2F1, FOSL2, RBL1, FOXP3, IFI16, NFE2L2, SP100, TP53, CTCF, EP300, ETS1, E2F6, NR3C1, YY1, JUN, TP53BP1, RB1, HMGA1, ESR1, AHR, CREBBP, FOXA10
PIK3CAYES1FOXO30
RRAS2YES1BTF30
PARK2YES1SIM20
CTNNB1YES8AR, NKX2-5, LEF1, TP53, NELFCD, SOX6, ESR1, SIRT10
AKT1YES7APC, STAT3, GLI1, AR, TP53, RELA, NFKB10
CDH1YES49AR, MTA2, FOXM1, ZEB2, SNAI1, TWIST2, TWIST1, EZH2, RBBP7, FOXA2, TCF3, LMO2, SPDEF, YBX1, KLF4, MTA1, LCOR, HDAC3, DNMT1, FOXQ1, HOXA7, TCF12, ESR1, SIRT1, WT1, ZEB1, FOSB, SMARCA4, VDR, HDAC1, TFAP2A, RELA, PARP1, HMGA2, NFKB1, KLF8, HDGF, STAT3, GATA3, HDAC2, SNAI2, CBX7, SALL4, RB1, HMGA1, KLF6, ZNF217, SIX1, HIF1A0
MYCNO66E2F4, LEF1, PGR, FOXM1, TBP, FUBP1, TP53, MYBL2, SMAD4, MXI1, MYB, AATF, ZNF382, FOS, ZBTB7A, SP1, E2F5, RBL1, TCF4, TBL1X, EP300, SMAD7, HDAC3, TCF3, SRSF1, SMAD3, CNBP, TLX1, ESR1, SIRT1, WT1, APC, CTNNB1, CEBPE, PRDM1, IFI16, DLX5, HDAC10, ZNF300, JUN, ETS2, RELA, BCL6, NFKB1, BRCA1, E2F1, STAT3, HDAC11, CEBPA, HOXA1, PTTG1, PPARG, YY1, MTA1, HDAC2, NF1, SNIP1, RUNX3, RB1, CTCF, ENO1, BDP1, AHR, STAT4, RFX1, HNF4A2BRCA1, CTNNB1
CCND1NO62POU4F2, RELA, E2F4, MYBL2, AR, MECP2, PML, BHLHE41, EZH2, ATF2, PGR, JUND, FOS, PAX5, STAT5B, RUNX3, RNF14, POU2F1, EGR1, EP300, KLF4, HOXA1, STAT5A, CTNNB1, BRCA1, ESR1, SIRT1, VHL, SP1, KLF6, LEF1, HDAC1, KDM4B, NKX3-1, SOX2, HOXB7, JUN, ZNF24, TP53, NANOG, E2F8, NELFCD, NFKB1, E2F1, FHL2, STAT3, TCF4, BTG2, NR3C1, SP4, TSC22D3, SNIP1, HEXIM1, ING4, LIN28A, HIF1A, SMARCA4, SP3, MYC, PPARG, KLF5, SOX62BRCA1, CTNNB1
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
BRCA1PIK3CANo8ATR, ESR1, LCK, HDAC1, PIK3R1, SMAD3, AKT1, STAT1
BRCA1RRAS2No3PIK3R1, XRCC6, CDK2
BRCA1PARK2No52TPM1, AURKA, HNRNPA1, ABL1, VCP, MAPK1, TARDBP, HNRNPD, UBE2L3, TPM3, SNRNP200, MYL12A, PSMD9, PGAM5, UBE2E2, TUBG1, HSP90AA1, UBE2D2, CCNE1, BECN1, SUMO1, DNAJB1, NPM1, HNRNPA2B1, CCNB1, SRSF1, RAD23B, MTOR, CTNNB1, UBE2N, PSMA7, COMMD1, UBE2D3, RUVBL2, UBE2J1, PSMA6, PCNA, HSPD1, CBX1, DNAJA1, HNRNPC, HSPA8, BACH1, MARCKSL1, BCL2, XRCC6, UBE2E1, CBX3, TUBB, RFC4, UBC, PLK1
BRCA1CTNNB1Yes46AR, HNRNPA1, ABL1, AURKA, TFAP2A, MSN, EZH2, EZR, AKT1, CCNA2, SP1, CCNE1, ASH2L, RPSA, DDB1, HNRNPA2B1, DHX9, SMAD3, NUP153, FOXO3, YWHAZ, ESR1, CDK2, HDAC1, HERC2, SMARCA5, JUP, TOP2A, RUVBL2, PARP1, EP300, BRCA1, FHL2, FANCA, HSPA8, SKP1, UBE2D1, CREBBP, HUWE1, PLK1, CTBP1, PIK3R1, HIF1A, SMARCA4, AHR, PHB2
BRCA1AKT1Yes42AR, PIAS1, VCP, PPP2CA, EZH2, PPP1CA, CTBP1, SKP2, COMMD1, YBX1, ITPR1, SMARCC2, NPM1, DNAJB1, SMAD3, CTNNB1, DNMT1, FOXO3, YWHAZ, TOPBP1, ESR1, SMARCB1, PRKDC, HSP90AA1, NFE2L2, PPP1CB, AKT1, EP300, BRCA1, SMARCC1, CREBBP, FANCA, HSPA8, RICTOR, XIAP, MTOR, TUBB, CLK2, ENO1, MAPKAP1, CSNK2A1, PHB2
BRCA1SEPT9No6HNRNPD, EED, MSH2, TPM3, HSPD1, HIF1A
BRCA1CDH1No17XRCC5, HSPA8, CTNNB1, EZR, HDAC2, HDAC1, ACTG1, CREBBP, PPP1CA, JUP, HSP90AA1, CCNB1, HSPD1, POLR2E, EP300, E2F1, SKP2
PIK3CARRAS2No1PIK3R1
PIK3CAPARK2No4DDX5, RPS20, YWHAH, SQSTM1
PIK3CACTNNB1No10DDX5, AKT1, HDAC1, NOTCH1, SMAD2, PIK3R1, SMAD3, ESR1, NTRK1, CBL
PIK3CAAKT1Yes12IL13RA2, IL24, AKT1, NOTCH1, IRS1, DDX5, ERBB3, SMAD2, ESR1, SMAD3, THRSP, APPL1
PIK3CASEPT9No1NTRK1
PIK3CACDH1No1HDAC1
RRAS2PARK2No4MLLT4, XRCC6, SNCA, TRAF2
RRAS2CTNNB1No3PIK3R1, CCDC8, CDK2
RRAS2AKT1No2SNCA, RAF1
PARK2CTNNB1Yes31HNRNPK, HNRNPA1, ABL1, PARK2, CUL1, CCNA1, NEK2, EGFR, DDX5, APP, RUVBL1, CCNE1, TCF4, UCHL1, AMOT, HNRNPA2B1, TUBA1A, LMNA, HSP90AB1, HIST1H1C, ELAVL1, RUVBL2, HDAC4, PRPF6, HSPA8, FUS, SERBP1, AURKA, PLK1, HNRNPM, RANBP2
PARK2AKT1No40PLCG1, PICK1, HSP90AB1, VCP, PSMC5, YWHAE, BCL2L1, RPTOR, VIM, MTOR, EGFR, HSPA5, UCHL1, IKBKG, STUB1, COMMD1, CAMK2A, MDH1, MAPT, PSMB4, NPM1, DNAJB1, ARRB1, APP, CTNNB1, SNCA, PINK1, HSPA9, LRRK2, GAPDH, HK1, HSP90AA1, ACTB, HSPA8, HSPA4, TUBB, DDX5, IMPDH2, TPM4, ARRB2
PARK2SEPT9No6HNRNPD, TPM3, HSPD1, HSPA5, IKBKG, APP
PARK2CDH1No15HSPA9, HSPA8, NIPSNAP1, MYO6, PTTG1, HSP90AA1, LMNA, CCNB1, SET, EGFR, HSPD1, HSPA5, CTNNB1, IGHA1, C1QBP
CTNNB1AKT1Yes43KAT2B, DDX5, HSP90AB1, AR, SMAD4, EZH2, CREB1, EGFR, JADE1, TRAF4, CTBP1, CHUK, IQGAP1, GSK3B, UCHL1, SMAD7, USP4, SMAD3, APP, FOXO4, BRCA1, PYGO2, SIRT1, NOTCH1, GSK3A, SFN, MAPK9, MAPK8, SMAD2, SLC9A3R1, NR4A1, AKT1, EP300, FOXO3, FANCA, HSPA8, ILK, CREBBP, IKBKB, PTEN, YWHAZ, ESR1, PHB2
CTNNB1SEPT9No5NTRK1, HIF1A, OBSL1, APP, XPO1
CTNNB1CDH1Yes36PTEN, MAGI1, MET, VEZT, CRYAB, VCL, CTNND1, EGFR, AJAP1, ACTN4, EZR, CTNNA1, FER, GSK3B, SMAD7, CDC27, LMNA, CDH3, HDAC1, IQGAP1, PSEN1, JUP, CDH1, AP2M1, FYN, EP300, CA9, HSPA8, ILK, CREBBP, CASP3, NDRG1, USP9X, MYO7A, FGFR1, RAB8B
AKT1SEPT9No4HSPA5, IKBKG, NEDD4, APP
AKT1CDH1No17HSPA9, HSPA8, CTNNB1, MDM2, ILK, EP300, CREBBP, SMAD7, IQGAP1, PPP1CA, PTEN, HSP90AA1, EGFR, SRC, HSPA5, GSK3B, SKP2
SEPT9CDH1No3HSPD1, CFTR, HSPA5

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
BRCA1CTNNB1No2CREBBP, EP300

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
BRCA1PIK3CANo-14SP1, AR, CTNNB1, CCND1, RELA, CREB1, PIK3R1, SMAD3, TP53, ESR1, SRC, PGR, AKT1, MYC
BRCA1RRAS2No-2ESR1, AKT1
BRCA1PARK2No-13HSP90AA1, UBE2D2, HSPA8, PCNA, UBE2L3, UBE2N, UBE2D3, ABL1, TUBG1, UBE2E1, UBC, UBE2E2, HIF1A
BRCA1CTNNB1Yesactivation, binding28AR, HIST3H3, AKT1, CTBP1, CCNE1, CCND1, SMAD3, NCOA2, SIRT1, HDAC1, JUN, TOP2A, ABL1, SRC, EP300, FHL2, KLK3, CDK2, CREBBP, HDAC2, PLK1, PIK3R1, HIF1A, SMARCA4, UBC, MYC, RELA, CDKN1B
BRCA1AKT1Yesbinding38AR, TERF1, TOPBP1, TP53, NPM1, BMI1, PCGF2, SKP2, CCND1, RB1, CREB1, STAT5A, SMAD3, CCNA2, CTNNB1, E2F1, SIRT1, CDKN1A, ESR1, HSP90AA1, JUN, ATF2, RELA, SRC, EP300, FANCA, HSPA8, UBE2D1, CREBBP, AURKA, PPP1CA, GADD45A, PIK3R1, HIF1A, CCNB1, UBC, MYC, CDKN1B
BRCA1CDH1No-27AR, AKT1, TP53, ANAPC11, CTBP1, SKP2, SUMO1, CCND1, RB1, CDC27, STAT5A, SMAD3, CTNNB1, CDC23, HDAC1, JUN, ABL1, SRC, EP300, FHL2, ANAPC7, HDAC2, CBX7, PIK3R1, SMARCA4, UBC, MYC
PIK3CARRAS2Yesactivation, binding9MAP2K2, ESR1, MAP2K1, SOS1, PIK3CB, RAF1, PIK3CG, PIK3CD, AKT1
PIK3CAPARK2No-3BCL2L1, BECN1, TRAF2
PIK3CACTNNB1Yesactivation59MYC, BCL2L1, EGFR, MET, PRKCZ, RET, ZYX, VCL, ACTN1, CTNND1, CDC42, RAP1A, RAP1B, VEGFA, CTNNA1, HGF, KDR, GSK3B, RHOA, ACTA1, PTK2, EPHA2, ERBB2, ERBB3, DLG1, SMAD2, SMAD3, YWHAZ, AKT2, IGF1, PRKCI, AR, PTPN1, NOTCH1, BDNF, SLC9A3R1, CDH1, AKT1, SRC, FYN, NFKB1, PRKCA, STAT3, GDNF, CDH2, RAC1, PTPN11, IGF1R, RELA, MTOR, PIK3R1, ERBB4, FLT3, EGF, GFRA1, EFNA1, FGFR1, CCND1, RAC3
PIK3CAAKT1Yesactivation, binding108ITGB3, PTEN, PLCG1, TP53, CDC42, SOS1, RAP1A, PDGFB, ACTN4, PDGFRB, ACTA1, CTNNB1, GNGT1, BECN1, BDNF, PIK3CB, RELA, CBLB, RELN, IL2, RRAS2, MTOR, INS, JAK1, PIK3R5, GNB1, ESR1, VAV2, FLT3, BCL2L1, AKT2, ITGA2B, RPTOR, PGF, ANGPT2, ITGA6, RHOA, PREX1, PIK3R1, BCR, RPS6KB2, APPL1, IGF1, PTPN1, CDH1, PIK3R3, PDPK1, ITGB4, GRB2, GAB1, PIK3CD, ZYX, PELP1, VLDLR, AR, CSK, TPTE2, RAP1B, DAB1, INSR, GSK3B, CCND1, CREB1, SMAD3, RAF1, ERBB3, TPTE, LCK, HRAS, NOTCH1, GAB2, DOK1, CDH2, VEGFA, RAC1, RICTOR, PRKCZ, GNAI3, CASP9, IL2RB, EFNA1, RAC3, PTPN11, MAP3K5, PIK3CG, GNAI1, DAB2IP, ANGPT1, RRAS, SHC1, YWHAZ, CSF2, TSC1, S1PR1, SLC9A3R1, SMAD2, SRC, NFKB1, MYC, STAT3, KRAS, IL3, ARF6, RPS6KB1, IRS1, VAV1, IRS2, LAT
PIK3CACDH1Yesactivation, binding58RAC1, CDH2, MET, CD2AP, RET, ZYX, VCL, ACTN1, CTNND1, CDC42, EGFR, RAP1B, DLG1, HGF, ITGA6, GFRA1, ITGB4, RHOA, ACTA1, CTNNA1, RAP1A, EPHA2, ERBB2, SMAD3, TLN1, CTNNB1, ERBB3, KIT, PRKCA, PRKCI, AR, NOTCH1, GAB2, TP53, RPS6KB1, SMAD2, AKT1, SRC, FYN, NFKB1, EFNA1, YES1, STAT3, GDNF, IL4, RICTOR, VAV1, PRKCZ, RPTOR, PIK3R1, PTEN, IGF1, EGF, IRS2, MYC, CCND1, IGF1R, RAC3
PIK3CAOPCMLNo-1ERBB2
RRAS2CTNNB1No-2PIK3CA, AKT1
RRAS2AKT1Yesactivation, binding10RALGDS, PIK3CG, PHLPP1, PHLPP2, SOS1, PIK3CB, RAF1, PIK3CA, ESR1, PIK3CD
RRAS2CDH1No-2PIK3CA, AKT1
PARK2CTNNB1No-7BCL2L1, BCL2, CUL1, RPS27A, ABL1, UBC, HIF1A
PARK2AKT1No-20BCL2L1, HSPA8, MCL1, VCP, PINK1, GAPDH, HTRA2, PARK7, HSPA4, BECN1, HSP90AA1, VDAC1, ARRB1, HIF1A, UBC, BCL2, SNCA, MAPT, STUB1, RPS27A
PARK2CDH1No-4VHL, UBC, BCL2, ABL1
CTNNB1AKT1Yesactivation, binding, catalysis97PTPN1, TJP1, CDC42, RAP1A, HDAC9, YWHAB, GJA1, HTT, YWHAH, ACTA1, FOXO3, GSK3A, BDNF, JUN, RELA, MYOD1, MMP9, MTOR, PIK3R1, YWHAG, TERT, FLT3, IRF3, KAT2B, AR, HNRNPA1, YWHAE, EZH2, EZR, PTGS2, FOS, RHOA, FOXO4, GLI1, IGF1, CBY1, CDH1, MMP2, CDKN1B, UBC, YWHAQ, HIF1A, ZYX, PPP2R5D, BCL2L1, SMAD4, BTRC, RAP1B, CHUK, IQGAP1, NFKB1, CCND1, AXIN1, ERBB3, FOXO1, SMAD3, BRCA1, SFN, FBXW11, PPP2R5A, BIRC5, HSPB3, NOTCH1, SMAD2, IKBKB, CDH2, VEGFA, EP300, MAPK14, NF2, RAC1, PRKCZ, IGF2, RUNX3, SIRT1, EFNA1, RAC3, PTPN11, FOXM1, HSPB2-C11ORF52, SNAI1, SNAI2, WNT3A, RPS27A, BCL2, SMAD7, PIK3CA, COPS5, YWHAZ, AKT2, SLC9A3R1, SRC, GSK3B, STAT3, ILK, CREBBP, MYC
CTNNB1CDH1Yesactivation, binding133ABL1, HGS, RET, VASP, TJP1, CDC42, PVRL1, RAP1A, HDAC9, PIP5K1C, CTTN, ACTA1, PARD6A, CDH17, PKP4, LRP5, NCSTN, PSEN1, JUN, VCL, AKT1, PRKCA, CA9, MMP9, ENAH, PIK3R1, IGF1, CDH5, AR, CDH11, IL8, CDH10, SNX1, IGF2, EZR, MMP7, PTGS2, DNM2, PVRL2, PKD1, PROC, FOS, RHOA, CDH9, GLI1, STX4, NUMB, CDH8, SMARCA4, ACTN1, EGFR, ITGB7, DLG5, MYO6, EXOC3, IGF1R, HDAC2, ID2, CDX1, LIMA1, UBC, GFRA1, ZYX, BMP4, MGAT3, RAC1, SMAD4, GNA12, PIP5K1A, RAP1B, CTNNA1, IQGAP1, SOX9, CCND1, CTNND2, ERBB3, GDNF, SMAD3, GNA13, CDH3, LEF1, SNAI1, HDAC1, NOTCH1, SMAD2, CDH2, EP300, FOXO3, FHL2, PLEKHA7, FMN1, PRKCZ, CTNND1, MEP1B, EZH2, EFNA1, RAC3, FOXM1, MET, AP1M1, SNAI2, IGF2BP1, CTBP1, DLG1, PRKCI, BCL2, CBLL1, SMAD7, EXOC4, PIK3CA, EPHA2, CDH15, ERBB2, CDH18, CDX2, ITGAE, F2RL2, EGF, JUP, APC2, SRC, FYN, NFKB1, CDH4, STAT3, CDH6, ILK, AJUBA, HGF, RAB5A, ADAM10, MYC, KLF4
CTNNB1OPCMLNo-1ERBB2
AKT1CDH1Yesactivation, binding80ZYX, CDH2, FOXM1, SNAI2, POSTN, ACTA1, TP53, SNAI1, RAC1, SMAD4, CAV1, FOXA2, GLI2, SERPINE1, CTGF, FOXO3, EZR, FOS, FGF2, SKP2, PTGS2, IQGAP1, CD44, PDCD4, ITGA6, ITGB4, NFKB1, RHOA, SMAD7, PIK3R1, PIK3CA, RAP1A, HDAC9, SMAD3, CTNNB1, TGFB1, ERBB3, LEP, CDC42, WT1, NOTCH1, STAT5A, RAP1B, GLI1, MDM2, F2R, AR, SLC3A2, IQGAP2, GAB2, IGF1, RPS6KB1, JUN, VAV1, PTEN, SRC, EP300, EFNA1, DLC1, STAT3, SMAD2, FGF13, RPTOR, BCL2, ILK, RICTOR, PRKCZ, MMP9, IGF2, RB1, TJP1, STAT5B, RAC3, EZH2, UBC, IRS2, MYC, CCND1, NOX1, FOXA1
AKT1OPCMLNo-1DNMT1
CDH1OPCMLNo-1ERBB2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
BRCA1CDH1No-1SMAD3
CTNNB1CDH1YesPolycystin-1-E-cadherin-beta-catenin complex;Cell-cell junction complex (CDH1-CTNNB1);Polycystin-1-E-cadherin-beta-catenin-Flotillin-2 complex;Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1)10ACTN1, PKD1, BCAR1, VCL, PXN, JUP, PTK2, SRC, FLOT2, TLN1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Bacterial invasion of epithelial cellshsa051006.344SEPT9, CTNNB1, CDH1, PIK3CA
Proteoglycans in cancerhsa052055.024RRAS2, AKT1, CTNNB1, PIK3CA
Endometrial cancerhsa052136.814AKT1, CTNNB1, CDH1, PIK3CA
Pathways in cancerhsa052003.984AKT1, CDH1, CTNNB1, PIK3CA
Rap1 signaling pathwayhsa040154.974CTNNB1, AKT1, PIK3CA, CDH1
HTLV-I infectionhsa051664.594RRAS2, AKT1, CTNNB1, PIK3CA
Signaling pathways regulating pluripotency of stem cellshsa045505.63AKT1, PIK3CA, CTNNB1
Colorectal cancerhsa052106.523AKT1, CTNNB1, PIK3CA
Melanomahsa052186.563AKT1, PIK3CA, CDH1
cAMP signaling pathwayhsa040245.053RRAS2, PIK3CA, AKT1
Prostate cancerhsa052156.113AKT1, CTNNB1, PIK3CA
Tight junctionhsa045305.533RRAS2, AKT1, CTNNB1
Ras signaling pathwayhsa040144.93RRAS2, PIK3CA, AKT1
Focal adhesionhsa045104.923AKT1, CTNNB1, PIK3CA
Thyroid hormone signaling pathwayhsa049195.823AKT1, PIK3CA, CTNNB1
PI3K-Akt signaling pathwayhsa041514.213BRCA1, AKT1, PIK3CA
Pathogenic Escherichia coli infectionhsa051306.992CDH1, CTNNB1
Platelet activationhsa046115.662PIK3CA, AKT1
Acute myeloid leukemiahsa052216.742PIK3CA, AKT1
cGMP-PKG signaling pathwayhsa040225.322AKT1, PIK3CA
MAPK signaling pathwayhsa040104.632RRAS2, AKT1
Thyroid cancerhsa052167.482CDH1, CTNNB1
Gliomahsa052146.662AKT1, PIK3CA
Jak-STAT signaling pathwayhsa046305.442AKT1, PIK3CA
Leukocyte transendothelial migrationhsa046705.742PIK3CA, CTNNB1
Cholinergic synapsehsa047255.882AKT1, PIK3CA
Choline metabolism in cancerhsa052316.092PIK3CA, AKT1
FoxO signaling pathwayhsa040685.632AKT1, PIK3CA
Osteoclast differentiationhsa043805.642PIK3CA, AKT1
HIF-1 signaling pathwayhsa040665.92AKT1, PIK3CA
Chemokine signaling pathwayhsa040625.192AKT1, PIK3CA
Ubiquitin mediated proteolysishsa041205.632BRCA1, PARK2
Chagas disease (American trypanosomiasis)hsa051425.992AKT1, PIK3CA
Pancreatic cancerhsa052126.562AKT1, PIK3CA
Epstein-Barr virus infectionhsa051694.972AKT1, PIK3CA
Toxoplasmosishsa051455.712PIK3CA, AKT1
Influenza Ahsa051645.212AKT1, PIK3CA
Apoptosishsa042106.232PIK3CA, AKT1
Hepatitis Chsa051605.682AKT1, PIK3CA
Hepatitis Bhsa051615.522PIK3CA, AKT1
Measleshsa051625.62PIK3CA, AKT1
Chronic myeloid leukemiahsa052206.482AKT1, PIK3CA
Renal cell carcinomahsa052116.62AKT1, PIK3CA
VEGF signaling pathwayhsa043706.772PIK3CA, AKT1
MicroRNAs in cancerhsa052065.382BRCA1, PIK3CA
Toll-like receptor signaling pathwayhsa046206.02PIK3CA, AKT1
T cell receptor signaling pathwayhsa046606.012AKT1, PIK3CA
Fc gamma R-mediated phagocytosishsa046666.212PIK3CA, AKT1
B cell receptor signaling pathwayhsa046626.522AKT1, PIK3CA
Adherens junctionhsa045206.262CDH1, CTNNB1
Hippo signaling pathwayhsa043905.372CDH1, CTNNB1
ErbB signaling pathwayhsa040126.152PIK3CA, AKT1
Progesterone-mediated oocyte maturationhsa049146.182AKT1, PIK3CA
Estrogen signaling pathwayhsa049156.112PIK3CA, AKT1
TNF signaling pathwayhsa046685.962PIK3CA, AKT1
AMPK signaling pathwayhsa041525.82AKT1, PIK3CA
Prolactin signaling pathwayhsa049176.62PIK3CA, AKT1
mTOR signaling pathwayhsa041506.722AKT1, PIK3CA
Regulation of actin cytoskeletonhsa048104.92RRAS2, PIK3CA
Carbohydrate digestion and absorptionhsa049737.282PIK3CA, AKT1
Non-small cell lung cancerhsa052236.882AKT1, PIK3CA
Insulin signaling pathwayhsa049105.552PIK3CA, AKT1
Neurotrophin signaling pathwayhsa047225.782PIK3CA, AKT1
Non-alcoholic fatty liver disease (NAFLD)hsa049325.512PIK3CA, AKT1
Central carbon metabolism in cancerhsa052306.72AKT1, PIK3CA
Fc epsilon RI signaling pathwayhsa046646.62AKT1, PIK3CA
Adrenergic signaling in cardiomyocyteshsa042615.442AKT1, PIK3CA
Small cell lung cancerhsa052226.172PIK3CA, AKT1

NET-GE enrichment

Term New enriched termICP valueGenes
Salmonella infection (hsa05132) NEW6.290.003AKT1, CDH1, CTNNB1, PIK3CA
Signaling pathways regulating pluripotency of stem cells (hsa04550) -5.60.001BRCA1, AKT1, CTNNB1, CDH1, PIK3CA
Hedgehog signaling pathway (hsa04340) NEW7.010.011AKT1, CDH1, CTNNB1
Acute myeloid leukemia (hsa05221) -6.740.016AKT1, CTNNB1, PIK3CA
Endometrial cancer (hsa05213) -6.810.0AKT1, CTNNB1, CDH1, PIK3CA
Colorectal cancer (hsa05210) -6.520.008AKT1, CTNNB1, PIK3CA
Chronic myeloid leukemia (hsa05220) -6.480.029AKT1, PIK3CA, CDH1
Melanoma (hsa05218) -6.560.032AKT1, PIK3CA, CDH1
Prostate cancer (hsa05215) -6.110.019AKT1, CTNNB1, PIK3CA
Tight junction (hsa04530) -5.530.014AKT1, RRAS2, CDH1, CTNNB1
Leukocyte transendothelial migration (hsa04670) -5.740.009CDH1, AKT1, PIK3CA, CTNNB1
Central carbon metabolism in cancer (hsa05230) -6.70.016AKT1, PIK3CA, CDH1
FoxO signaling pathway (hsa04068) -5.630.0CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
Osteoclast differentiation (hsa04380) -5.640.015CTNNB1, AKT1, CDH1, PIK3CA
Cellular communityNEW3.570.023AKT1, RRAS2, CTNNB1, CDH1, PIK3CA
HTLV-I infection (hsa05166) -4.590.021CTNNB1, RRAS2, CDH1, PIK3CA, AKT1, BRCA1
Wnt signaling pathway (hsa04310) NEW5.490.02CDH1, BRCA1, CTNNB1, AKT1
Measles (hsa05162) -5.60.014BRCA1, CDH1, AKT1, PIK3CA
Cancers: OverviewNEW2.720.031CTNNB1, RRAS2, CDH1, PIK3CA, AKT1, BRCA1
Renal cell carcinoma (hsa05211) -6.60.027AKT1, PIK3CA, CDH1
Infectious diseases: BacterialNEW3.760.042CTNNB1, CDH1, SEPT9, AKT1, PIK3CA, BRCA1
Bacterial invasion of epithelial cells (hsa05100) -6.340.0SEPT9, CTNNB1, CDH1, PIK3CA
Proteoglycans in cancer (hsa05205) -5.020.0CTNNB1, RRAS2, CDH1, PIK3CA, AKT1, BRCA1
MicroRNAs in cancer (hsa05206) -5.380.001BRCA1, AKT1, CTNNB1, CDH1, PIK3CA
Rap1 signaling pathway (hsa04015) -4.970.008CTNNB1, AKT1, PIK3CA, CDH1
Adherens junction (hsa04520) -6.260.049CDH1, AKT1, CTNNB1
Hippo signaling pathway (hsa04390) -5.370.045BRCA1, AKT1, CDH1, CTNNB1
Prolactin signaling pathway (hsa04917) -6.60.042AKT1, CTNNB1, PIK3CA
Progesterone-mediated oocyte maturation (hsa04914) -6.180.0CDH1, BRCA1, AKT1, CTNNB1, PIK3CA
MAPK signaling pathway (hsa04010) -4.630.0CTNNB1, RRAS2, CDH1, PIK3CA, AKT1, BRCA1
Thyroid hormone signaling pathway (hsa04919) -5.820.005BRCA1, AKT1, CTNNB1, PIK3CA
Cell motilityNEW4.90.005CDH1, RRAS2, AKT1, CTNNB1, PIK3CA
Cell growth and deathNEW4.410.019BRCA1, AKT1, CDH1, CTNNB1, PIK3CA
Regulation of actin cytoskeleton (hsa04810) -4.90.005CDH1, RRAS2, AKT1, CTNNB1, PIK3CA
Human DiseasesNEW1.540.023CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1, BRCA1
Hepatitis C (hsa05160) -5.680.011AKT1, CDH1, CTNNB1, PIK3CA
Alcoholism (hsa05034) NEW5.590.017PARK2, AKT1, CTNNB1, PIK3CA
Non-small cell lung cancer (hsa05223) -6.880.02AKT1, PIK3CA, CTNNB1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Immune SystemR-HSA-1682562.375AKT1, CTNNB1, PARK2, PIK3CA, CDH1
Adaptive Immune SystemR-HSA-12802183.194PARK2, AKT1, CDH1, PIK3CA
Signal TransductionR-HSA-1625821.784CDH1, AKT1, CTNNB1, PIK3CA
VEGFA-VEGFR2 PathwayR-HSA-44200974.73AKT1, CTNNB1, PIK3CA
Diseases of signal transductionR-HSA-56632024.893AKT1, CTNNB1, PIK3CA
Signaling by VEGFR-HSA-1941384.663AKT1, CTNNB1, PIK3CA
Innate Immune SystemR-HSA-1682493.173AKT1, CTNNB1, PIK3CA
Cell-Cell communicationR-HSA-15009315.873CDH1, CTNNB1, PIK3CA
Programmed Cell DeathR-HSA-53578015.653CDH1, AKT1, CTNNB1
ApoptosisR-HSA-1095815.683CTNNB1, AKT1, CDH1
DiseaseR-HSA-16436853.333AKT1, PIK3CA, CTNNB1
PI-3K cascade:FGFR4R-HSA-56547206.372PIK3CA, AKT1
Signaling by PDGFR-HSA-1867974.532PIK3CA, AKT1
PI3K/AKT activationR-HSA-1982036.322AKT1, PIK3CA
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.852PIK3CA, AKT1
GPVI-mediated activation cascadeR-HSA-1146047.182AKT1, PIK3CA
Signaling by Rho GTPasesR-HSA-1943154.432CTNNB1, CDH1
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.622AKT1, PIK3CA
Apoptotic execution phaseR-HSA-751537.282CDH1, CTNNB1
IGF1R signaling cascadeR-HSA-24289244.852PIK3CA, AKT1
Downstream signal transductionR-HSA-1867634.652AKT1, PIK3CA
GAB1 signalosomeR-HSA-1802926.312AKT1, PIK3CA
Signaling by ERBB4R-HSA-12363944.72AKT1, PIK3CA
IRS-related events triggered by IGF1RR-HSA-24289284.852AKT1, PIK3CA
Adherens junctions interactionsR-HSA-4189907.982CDH1, CTNNB1
Signaling by Insulin receptorR-HSA-747524.732AKT1, PIK3CA
Developmental BiologyR-HSA-12667383.482AKT1, CTNNB1
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.952AKT1, PIK3CA
deactivation of the beta-catenin transactivating complexR-HSA-37694027.592AKT1, CTNNB1
Downstream signaling of activated FGFR1R-HSA-56546874.712PIK3CA, AKT1
Signalling by NGFR-HSA-1665204.232AKT1, PIK3CA
PI3K CascadeR-HSA-1097046.682AKT1, PIK3CA
Apoptotic cleavage of cellular proteinsR-HSA-1114657.732CTNNB1, CDH1
PI-3K cascade:FGFR1R-HSA-56546896.372PIK3CA, AKT1
IRS-mediated signallingR-HSA-1123994.872AKT1, PIK3CA
Cell-cell junction organizationR-HSA-4212707.032CDH1, CTNNB1
CD28 co-stimulationR-HSA-3893567.982PIK3CA, AKT1
CD28 dependent PI3K/Akt signalingR-HSA-3893578.592AKT1, PIK3CA
Apoptotic cleavage of cell adhesion proteinsR-HSA-3519069.522CTNNB1, CDH1
Downstream signaling of activated FGFR3R-HSA-56547084.712PIK3CA, AKT1
Insulin receptor signalling cascadeR-HSA-747514.852AKT1, PIK3CA
DAP12 signalingR-HSA-24244914.642AKT1, PIK3CA
Signaling by FGFR4R-HSA-56547434.692PIK3CA, AKT1
Signaling by FGFR3R-HSA-56547414.692AKT1, PIK3CA
Signaling by FGFRR-HSA-1902364.672AKT1, PIK3CA
PI3K/AKT Signaling in CancerR-HSA-22195286.562AKT1, PIK3CA
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.032PIK3CA, AKT1
GPCR downstream signalingR-HSA-3883963.072PIK3CA, AKT1
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.592AKT1, PIK3CA
Cell junction organizationR-HSA-4467286.512CTNNB1, CDH1
Metabolism of proteinsR-HSA-3924993.412BRCA1, CTNNB1
Signaling by SCF-KITR-HSA-14335574.732PIK3CA, AKT1
TCF dependent signaling in response to WNTR-HSA-2016815.362AKT1, CTNNB1
G beta:gamma signalling through PI3KgammaR-HSA-3924517.42AKT1, PIK3CA
PI3K events in ERBB2 signalingR-HSA-19636426.372PIK3CA, AKT1
PI-3K cascade:FGFR2R-HSA-56546956.372PIK3CA, AKT1
Downstream signaling of activated FGFR2R-HSA-56546964.712AKT1, PIK3CA
Signaling by EGFRR-HSA-1779294.592PIK3CA, AKT1
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.512AKT1, PIK3CA
RHO GTPase EffectorsR-HSA-1952584.942CDH1, CTNNB1
Signaling by WntR-HSA-1957214.792AKT1, CTNNB1
PIP3 activates AKT signalingR-HSA-12576046.372AKT1, PIK3CA
Signaling by GPCRR-HSA-3727902.682PIK3CA, AKT1
Signaling by FGFR2R-HSA-56547384.682AKT1, PIK3CA
Signaling by FGFR1R-HSA-56547364.692PIK3CA, AKT1
PI3K events in ERBB4 signalingR-HSA-12503426.372AKT1, PIK3CA
G-protein beta:gamma signallingR-HSA-3977957.312AKT1, PIK3CA
HemostasisR-HSA-1095823.982PIK3CA, AKT1
PI-3K cascade:FGFR3R-HSA-56547106.372PIK3CA, AKT1
DAP12 interactionsR-HSA-21721274.562AKT1, PIK3CA
RHO GTPases activate IQGAPsR-HSA-56264678.342CDH1, CTNNB1
Downstream signaling of activated FGFR4R-HSA-56547164.712AKT1, PIK3CA
Signaling by ERBB2R-HSA-12279864.662PIK3CA, AKT1
MetabolismR-HSA-14307282.342PIK3CA, AKT1
VEGFR2 mediated vascular permeabilityR-HSA-52189208.282AKT1, CTNNB1
Platelet activation, signaling and aggregationR-HSA-760025.152PIK3CA, AKT1
Costimulation by the CD28 familyR-HSA-3888416.562PIK3CA, AKT1

NET-GE enrichment

Term New enriched termICP valueGenes
PI-3K cascade:FGFR4 (R-HSA-5654720) -6.370.049AKT1, CDH1, PIK3CA
Signaling by FGFR3 in disease (R-HSA-5655332) NEW8.520.042PIK3CA, CDH1
Apoptotic execution phase (R-HSA-75153) -7.280.004CDH1, AKT1, CTNNB1
Interleukin-2 signaling (R-HSA-451927) NEW5.050.038AKT1, CTNNB1, CDH1, PIK3CA
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530) NEW7.050.007AKT1, CDH1, PIK3CA
PI3K events in ERBB2 signaling (R-HSA-1963642) -6.370.049AKT1, CDH1, PIK3CA
Cellular responses to stress (R-HSA-2262752) NEW4.560.006PARK2, BRCA1, AKT1, CTNNB1, CDH1
Cell-Cell communication (R-HSA-1500931) -5.870.018AKT1, CDH1, CTNNB1, PIK3CA
Programmed Cell Death (R-HSA-5357801) -5.650.028CDH1, AKT1, CTNNB1
Adherens junctions interactions (R-HSA-418990) -7.980.042CDH1, CTNNB1
Adaptive Immune System (R-HSA-1280218) -3.190.022CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
PIP3 activates AKT signaling (R-HSA-1257604) -6.370.049AKT1, PIK3CA, CDH1
PI-3K cascade:FGFR3 (R-HSA-5654710) -6.370.049AKT1, CDH1, PIK3CA
Apoptotic cleavage of cellular proteins (R-HSA-111465) -7.730.002CTNNB1, AKT1, CDH1
PI-3K cascade:FGFR1 (R-HSA-5654689) -6.370.049AKT1, CDH1, PIK3CA
Gastrin-CREB signalling pathway via PKC and MAPK (R-HSA-881907) NEW4.260.017CDH1, PARK2, AKT1, CTNNB1, PIK3CA
Phospholipid metabolism (R-HSA-1483257) NEW5.830.004BRCA1, CDH1, AKT1, PIK3CA
CD28 co-stimulation (R-HSA-389356) -7.980.042PIK3CA, AKT1
Downstream signaling events of B Cell Receptor (BCR) (R-HSA-1168372) -5.590.009AKT1, CTNNB1, CDH1, PIK3CA
Metabolism of lipids and lipoproteins (R-HSA-556833) NEW3.790.005CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
FGFR1 mutant receptor activation (R-HSA-1839124) NEW8.120.0AKT1, CTNNB1, CDH1, PIK3CA
Signaling by FGFR in disease (R-HSA-1226099) NEW7.490.004AKT1, PIK3CA, CDH1
PI3K/AKT Signaling in Cancer (R-HSA-2219528) -6.560.03AKT1, CDH1, PIK3CA
Diseases of signal transduction (R-HSA-5663202) -4.890.003CDH1, PARK2, AKT1, CTNNB1, PIK3CA
CD28 dependent PI3K/Akt signaling (R-HSA-389357) -8.590.018AKT1, PIK3CA
Cell junction organization (R-HSA-446728) -6.510.034AKT1, CTNNB1, CDH1
Signaling by FGFR1 in disease (R-HSA-5655302) NEW7.810.0AKT1, CDH1, CTNNB1, PIK3CA
Signalling to RAS (R-HSA-167044) NEW5.080.037AKT1, CTNNB1, CDH1, PIK3CA
PI-3K cascade:FGFR2 (R-HSA-5654695) -6.370.049AKT1, CDH1, PIK3CA
VEGFR2 mediated vascular permeability (R-HSA-5218920) -8.280.028AKT1, CTNNB1
Class B/2 (Secretin family receptors) (R-HSA-373080) NEW6.520.038AKT1, PIK3CA, CDH1
Signaling by Wnt (R-HSA-195721) -4.790.004CDH1, BRCA1, PARK2, CTNNB1, AKT1
Signalling to ERKs (R-HSA-187687) NEW5.040.042CDH1, AKT1, PIK3CA, CTNNB1
PI3K events in ERBB4 signaling (R-HSA-1250342) -6.370.049AKT1, PIK3CA, CDH1
PI3K Cascade (R-HSA-109704) -6.680.025AKT1, PIK3CA, CDH1
RHO GTPases activate IQGAPs (R-HSA-5626467) -8.340.026CDH1, CTNNB1
Apoptotic cleavage of cell adhesion proteins (R-HSA-351906) -9.520.013CTNNB1, CDH1
Apoptosis (R-HSA-109581) -5.680.026CTNNB1, AKT1, CDH1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.189CTNNB1, OPCML, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1, BRCA1
protein binding (GO:0005515) 0.469CTNNB1, OPCML, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1, BRCA1
organic cyclic compound binding (GO:0097159) 1.057CTNNB1, RRAS2, PARK2, PIK3CA, SEPT9, AKT1, BRCA1
heterocyclic compound binding (GO:1901363) 1.067CTNNB1, RRAS2, PARK2, PIK3CA, SEPT9, AKT1, BRCA1
catalytic activity (GO:0003824) 1.056RRAS2, PARK2, SEPT9, PIK3CA, AKT1, BRCA1
carbohydrate derivative binding (GO:0097367) 2.035SEPT9, AKT1, RRAS2, PIK3CA, CDH1
purine ribonucleoside triphosphate binding (GO:0035639) 2.224RRAS2, SEPT9, AKT1, PIK3CA
enzyme binding (GO:0019899) 2.274BRCA1, PARK2, CTNNB1, AKT1
nucleotide binding (GO:0000166) 1.964AKT1, RRAS2, SEPT9, PIK3CA
small molecule binding (GO:0036094) 1.894AKT1, RRAS2, SEPT9, PIK3CA
transferase activity (GO:0016740) 1.954BRCA1, PARK2, PIK3CA, AKT1
ribonucleotide binding (GO:0032553) 2.194RRAS2, SEPT9, AKT1, PIK3CA
purine nucleoside binding (GO:0001883) 2.224RRAS2, SEPT9, AKT1, PIK3CA
ribonucleoside binding (GO:0032549) 2.224AKT1, RRAS2, SEPT9, PIK3CA
purine ribonucleotide binding (GO:0032555) 2.24RRAS2, SEPT9, AKT1, PIK3CA
purine nucleotide binding (GO:0017076) 2.194RRAS2, SEPT9, AKT1, PIK3CA
ion binding (GO:0043167) 1.364BRCA1, PARK2, AKT1, CDH1
purine ribonucleoside binding (GO:0032550) 2.224AKT1, RRAS2, SEPT9, PIK3CA
nucleoside phosphate binding (GO:1901265) 1.964RRAS2, SEPT9, AKT1, PIK3CA
nucleoside binding (GO:0001882) 2.214AKT1, RRAS2, SEPT9, PIK3CA
transcription regulatory region DNA binding (GO:0044212) 3.033BRCA1, PARK2, CTNNB1
cytoskeletal protein binding (GO:0008092) 3.023BRCA1, PARK2, CDH1
regulatory region DNA binding (GO:0000975) 3.033BRCA1, PARK2, CTNNB1
regulatory region nucleic acid binding (GO:0001067) 3.033BRCA1, PARK2, CTNNB1
cation binding (GO:0043169) 1.43BRCA1, PARK2, CDH1
protein kinase binding (GO:0019901) 3.443PARK2, AKT1, CTNNB1
kinase binding (GO:0019900) 3.323PARK2, AKT1, CTNNB1
nucleic acid binding (GO:0003676) 1.443BRCA1, PARK2, CTNNB1
DNA binding (GO:0003677) 1.923BRCA1, PARK2, CTNNB1
receptor binding (GO:0005102) 2.433BRCA1, PARK2, CTNNB1
metal ion binding (GO:0046872) 1.413BRCA1, PARK2, CDH1
ubiquitin-like protein ligase binding (GO:0044389) 4.152BRCA1, PARK2
GTPase activating protein binding (GO:0032794) 7.12AKT1, CDH1
androgen receptor binding (GO:0050681) 6.072BRCA1, CTNNB1
macromolecular complex binding (GO:0044877) 2.612BRCA1, CTNNB1
zinc ion binding (GO:0008270) 2.662BRCA1, PARK2
molecular function regulator (GO:0098772) 2.512PIK3CA, AKT1
ubiquitin-like protein transferase activity (GO:0019787) 3.692BRCA1, PARK2
transition metal ion binding (GO:0046914) 2.482BRCA1, PARK2
pyrophosphatase activity (GO:0016462) 3.042RRAS2, SEPT9
ligase activity (GO:0016874) 3.722BRCA1, PARK2
transcription coactivator activity (GO:0003713) 4.042BRCA1, CTNNB1
transcription cofactor activity (GO:0003712) 3.442BRCA1, CTNNB1
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.652PARK2, CTNNB1
guanyl ribonucleotide binding (GO:0032561) 3.732RRAS2, SEPT9
transcription factor activity, transcription factor binding (GO:0000989) 3.362BRCA1, CTNNB1
transcription factor activity, protein binding (GO:0000988) 3.352BRCA1, CTNNB1
double-stranded DNA binding (GO:0003690) 3.092PARK2, CTNNB1
ATP binding (GO:0005524) 2.432PIK3CA, AKT1
GTP binding (GO:0005525) 3.782RRAS2, SEPT9
hydrolase activity (GO:0016787) 1.92RRAS2, SEPT9
tubulin binding (GO:0015631) 4.12BRCA1, PARK2
steroid hormone receptor binding (GO:0035258) 5.322BRCA1, CTNNB1
nuclear hormone receptor binding (GO:0035257) 4.72BRCA1, CTNNB1
enzyme regulator activity (GO:0030234) 2.852PIK3CA, AKT1
kinase activity (GO:0016301) 2.932AKT1, PIK3CA
GTPase activity (GO:0003924) 4.312RRAS2, SEPT9
nucleoside-triphosphatase activity (GO:0017111) 3.092RRAS2, SEPT9
beta-catenin binding (GO:0008013) 5.32PARK2, CDH1
protein phosphatase binding (GO:0019903) 4.932AKT1, CTNNB1
phosphatase binding (GO:0019902) 4.632AKT1, CTNNB1
hormone receptor binding (GO:0051427) 4.572BRCA1, CTNNB1
cell adhesion molecule binding (GO:0050839) 4.52CDH1, CTNNB1
ubiquitin-protein transferase activity (GO:0004842) 3.732BRCA1, PARK2
protein serine/threonine kinase activity (GO:0004674) 3.642AKT1, PIK3CA
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 3.032RRAS2, SEPT9
ubiquitin protein ligase binding (GO:0031625) 4.172BRCA1, PARK2
adenyl nucleotide binding (GO:0030554) 2.42PIK3CA, AKT1
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.082AKT1, PIK3CA
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.772AKT1, PIK3CA
protein kinase activity (GO:0004672) 3.272AKT1, PIK3CA
hydrolase activity, acting on acid anhydrides (GO:0016817) 3.032RRAS2, SEPT9
guanyl nucleotide binding (GO:0019001) 3.732RRAS2, SEPT9
adenyl ribonucleotide binding (GO:0032559) 2.412PIK3CA, AKT1
identical protein binding (GO:0042802) 2.632PARK2, AKT1
chromatin binding (GO:0003682) 3.642BRCA1, CTNNB1
nucleic acid binding transcription factor activity (GO:0001071) 2.652PARK2, CTNNB1

NET-GE enrichment

Term New enriched termICP valueGenes
protein C-terminus binding (GO:0008022) NEW4.50.002CDH1, BRCA1, CTNNB1, AKT1, PIK3CA
small conjugating protein ligase binding (GO:0044389) -4.150.011BRCA1, PARK2, CTNNB1, AKT1
phosphatase regulator activity (GO:0019208) NEW5.260.029AKT1, CTNNB1, PIK3CA
GTPase activating protein binding (GO:0032794) -7.10.021AKT1, CDH1
androgen receptor binding (GO:0050681) -6.070.001BRCA1, AKT1, CTNNB1
enzyme binding (GO:0019899) -2.270.037CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1, BRCA1
enhancer sequence-specific DNA binding (GO:0001158) NEW5.360.034BRCA1, CTNNB1, AKT1
G-protein coupled receptor binding (GO:0001664) NEW4.180.0CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
ubiquitin conjugating enzyme binding (GO:0031624) NEW6.30.026PARK2, PIK3CA
lipid kinase activity (GO:0001727) NEW7.950.006AKT1, PIK3CA
guanyl nucleotide binding (GO:0019001) -3.730.002RRAS2, PARK2, CDH1, SEPT9, AKT1, PIK3CA
receptor signaling protein activity (GO:0005057) NEW4.760.007CTNNB1, AKT1, CDH1, PIK3CA
guanyl ribonucleotide binding (GO:0032561) -3.730.002RRAS2, PARK2, CDH1, SEPT9, AKT1, PIK3CA
R-SMAD binding (GO:0070412) NEW6.650.049AKT1, CTNNB1
GTP binding (GO:0005525) -3.780.001RRAS2, PARK2, CDH1, SEPT9, AKT1, PIK3CA
tubulin binding (GO:0015631) -4.10.005SEPT9, BRCA1, PARK2, AKT1, CTNNB1
steroid hormone receptor binding (GO:0035258) -5.320.024BRCA1, CTNNB1, AKT1
gamma-catenin binding (GO:0045295) NEW7.170.019CTNNB1, CDH1
GTPase activity (GO:0003924) -4.310.001PARK2, SEPT9, RRAS2, PIK3CA, CDH1
phosphatidylinositol phosphate kinase activity (GO:0016307) NEW6.970.031AKT1, PIK3CA
small protein conjugating enzyme binding (GO:0044390) NEW6.210.028PARK2, PIK3CA
nucleoside-triphosphatase activity (GO:0017111) -3.090.002CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
protein kinase binding (GO:0019901) -3.440.006CTNNB1, PARK2, SEPT9, PIK3CA, AKT1, BRCA1
kinase binding (GO:0019900) -3.320.011CTNNB1, PARK2, SEPT9, PIK3CA, AKT1, BRCA1
phosphatase binding (GO:0019902) -4.630.011CDH1, AKT1, CTNNB1, PIK3CA
beta-catenin binding (GO:0008013) -5.30.022AKT1, CTNNB1, CDH1
binding, bridging (GO:0060090) NEW4.570.022BRCA1, PARK2, AKT1, PIK3CA
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) -3.030.003CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
ubiquitin protein ligase binding (GO:0031625) -4.170.011BRCA1, PARK2, CTNNB1, AKT1
cytoskeletal protein binding (GO:0008092) -3.020.006CTNNB1, RRAS2, PARK2, SEPT9, CDH1, AKT1, BRCA1
protein tyrosine phosphatase activity (GO:0004725) NEW5.090.002CDH1, PARK2, AKT1, CTNNB1
alpha-catenin binding (GO:0045294) NEW7.440.012AKT1, CTNNB1
hydrolase activity, acting on acid anhydrides (GO:0016817) -3.030.003CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
phosphoprotein phosphatase activity (GO:0004721) NEW4.550.014CDH1, PARK2, AKT1, CTNNB1
pyrophosphatase activity (GO:0016462) -3.040.003CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
calmodulin binding (GO:0005516) NEW4.550.0CDH1, AKT1, PARK2, PIK3CA, CTNNB1
protein domain specific binding (GO:0019904) NEW3.320.003CTNNB1, PARK2, SEPT9, CDH1, PIK3CA, AKT1, BRCA1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.269CTNNB1, OPCML, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1, BRCA1
single-organism cellular process (GO:0044763) 0.659CTNNB1, OPCML, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1, BRCA1
single-organism process (GO:0044699) 0.489CTNNB1, OPCML, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1, BRCA1
positive regulation of biological process (GO:0048518) 1.28CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1, BRCA1
positive regulation of cellular process (GO:0048522) 1.38CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1, BRCA1
biological regulation (GO:0065007) 0.398CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1, BRCA1
regulation of biological process (GO:0050789) 0.458CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1, BRCA1
regulation of cellular process (GO:0050794) 0.58CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1, BRCA1
cellular component organization (GO:0016043) 1.247CTNNB1, PARK2, SEPT9, CDH1, PIK3CA, AKT1, BRCA1
cellular component organization or biogenesis (GO:0071840) 1.227CTNNB1, PARK2, SEPT9, CDH1, PIK3CA, AKT1, BRCA1
regulation of primary metabolic process (GO:0080090) 1.086CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
regulation of metabolic process (GO:0019222) 1.026CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
positive regulation of cellular metabolic process (GO:0031325) 1.816CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
regulation of cellular metabolic process (GO:0031323) 1.076CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
cellular response to chemical stimulus (GO:0070887) 2.576CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
regulation of cell death (GO:0010941) 2.436CTNNB1, RRAS2, PARK2, PIK3CA, AKT1, BRCA1
positive regulation of metabolic process (GO:0009893) 1.746CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
cellular response to stimulus (GO:0051716) 1.976CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
positive regulation of macromolecule metabolic process (GO:0010604) 1.816CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
regulation of developmental process (GO:0050793) 2.16CTNNB1, PARK2, SEPT9, PIK3CA, AKT1, BRCA1
cellular response to organic substance (GO:0071310) 2.786CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
negative regulation of biological process (GO:0048519) 1.336CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
regulation of gene expression (GO:0010468) 1.376CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
developmental process (GO:0032502) 1.366CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.436CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
regulation of nitrogen compound metabolic process (GO:0051171) 1.366CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
response to chemical (GO:0042221) 1.986CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
regulation of localization (GO:0032879) 1.946CTNNB1, RRAS2, PARK2, CDH1, AKT1, BRCA1
response to organic substance (GO:0010033) 2.26CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
response to oxygen-containing compound (GO:1901700) 2.576CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
cellular response to oxygen-containing compound (GO:1901701) 3.226CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
regulation of macromolecule metabolic process (GO:0060255) 1.086CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
response to stimulus (GO:0050896) 1.226CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
anatomical structure development (GO:0048856) 1.586CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
negative regulation of cellular process (GO:0048523) 1.416CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
cellular response to endogenous stimulus (GO:0071495) 3.335BRCA1, CTNNB1, PARK2, AKT1, CDH1
cellular response to nitrogen compound (GO:1901699) 3.795AKT1, BRCA1, PARK2, CDH1, CTNNB1
metabolic process (GO:0008152) 0.585BRCA1, PARK2, AKT1, CTNNB1, PIK3CA
regulation of cellular localization (GO:0060341) 3.035BRCA1, CTNNB1, PARK2, AKT1, CDH1
regulation of organelle organization (GO:0033043) 2.725SEPT9, BRCA1, PARK2, CTNNB1, AKT1
regulation of protein metabolic process (GO:0051246) 1.935PARK2, BRCA1, AKT1, CTNNB1, PIK3CA
regulation of RNA biosynthetic process (GO:2001141) 1.555BRCA1, CTNNB1, PARK2, AKT1, CDH1
regulation of response to stimulus (GO:0048583) 1.545BRCA1, PARK2, CTNNB1, AKT1, PIK3CA
regulation of cellular biosynthetic process (GO:0031326) 1.385BRCA1, CTNNB1, PARK2, AKT1, CDH1
regulation of cellular component organization (GO:0051128) 2.015AKT1, BRCA1, PARK2, SEPT9, CTNNB1
regulation of cellular protein localization (GO:1903827) 3.435BRCA1, CTNNB1, PARK2, AKT1, CDH1
cellular biosynthetic process (GO:0044249) 1.375BRCA1, PARK2, AKT1, CTNNB1, PIK3CA
positive regulation of gene expression (GO:0010628) 2.355CDH1, BRCA1, PARK2, AKT1, CTNNB1
positive regulation of cellular biosynthetic process (GO:0031328) 2.35PARK2, BRCA1, AKT1, CTNNB1, CDH1
signal transduction (GO:0007165) 1.285BRCA1, RRAS2, AKT1, CTNNB1, PIK3CA
regulation of signaling (GO:0023051) 1.725BRCA1, PARK2, AKT1, CTNNB1, PIK3CA
regulation of cell communication (GO:0010646) 1.735BRCA1, PARK2, AKT1, CTNNB1, PIK3CA
regulation of apoptotic process (GO:0042981) 2.55BRCA1, PARK2, AKT1, CTNNB1, PIK3CA
response to organic cyclic compound (GO:0014070) 3.075PARK2, BRCA1, AKT1, CTNNB1, CDH1
regulation of protein localization (GO:0032880) 2.885BRCA1, CTNNB1, PARK2, AKT1, CDH1
response to endogenous stimulus (GO:0009719) 2.795PARK2, BRCA1, AKT1, CTNNB1, CDH1
organic substance biosynthetic process (GO:1901576) 1.345BRCA1, PARK2, CTNNB1, AKT1, PIK3CA
regulation of intracellular signal transduction (GO:1902531) 2.315PARK2, BRCA1, AKT1, CTNNB1, PIK3CA
cellular macromolecule metabolic process (GO:0044260) 0.935BRCA1, PARK2, AKT1, CTNNB1, PIK3CA
regulation of signal transduction (GO:0009966) 1.845BRCA1, PARK2, AKT1, CTNNB1, PIK3CA
cellular response to organonitrogen compound (GO:0071417) 3.875BRCA1, CTNNB1, PARK2, AKT1, CDH1
positive regulation of biosynthetic process (GO:0009891) 2.295AKT1, BRCA1, PARK2, CDH1, CTNNB1
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.465CDH1, BRCA1, PARK2, AKT1, CTNNB1
positive regulation of protein metabolic process (GO:0051247) 2.435BRCA1, PARK2, AKT1, CTNNB1, PIK3CA
positive regulation of response to stimulus (GO:0048584) 2.185BRCA1, PARK2, AKT1, CTNNB1, PIK3CA
organic substance metabolic process (GO:0071704) 0.635AKT1, BRCA1, PARK2, PIK3CA, CTNNB1
regulation of programmed cell death (GO:0043067) 2.495BRCA1, PARK2, CTNNB1, AKT1, PIK3CA
animal organ development (GO:0048513) 2.535CDH1, BRCA1, AKT1, CTNNB1, PIK3CA
positive regulation of cellular protein metabolic process (GO:0032270) 2.495BRCA1, PARK2, AKT1, CTNNB1, PIK3CA
regulation of transport (GO:0051049) 2.245AKT1, BRCA1, PARK2, CDH1, CTNNB1
negative regulation of programmed cell death (GO:0043069) 3.025BRCA1, PARK2, AKT1, CTNNB1, PIK3CA
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.565AKT1, BRCA1, PARK2, CDH1, CTNNB1
multicellular organismal process (GO:0032501) 1.455BRCA1, PARK2, AKT1, CTNNB1, PIK3CA
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.355BRCA1, CTNNB1, PARK2, AKT1, CDH1
negative regulation of cell death (GO:0060548) 2.955BRCA1, PARK2, CTNNB1, AKT1, PIK3CA
regulation of protein modification process (GO:0031399) 2.325BRCA1, PARK2, CTNNB1, AKT1, PIK3CA
regulation of biosynthetic process (GO:0009889) 1.375AKT1, BRCA1, PARK2, CDH1, CTNNB1
negative regulation of apoptotic process (GO:0043066) 3.045BRCA1, PARK2, CTNNB1, AKT1, PIK3CA
regulation of nucleic acid-templated transcription (GO:1903506) 1.555AKT1, BRCA1, PARK2, CDH1, CTNNB1
single-organism developmental process (GO:0044767) 1.495BRCA1, CTNNB1, AKT1, PIK3CA, CDH1
biosynthetic process (GO:0009058) 1.325BRCA1, PARK2, AKT1, CTNNB1, PIK3CA
positive regulation of transcription, DNA-templated (GO:0045893) 2.565BRCA1, CTNNB1, PARK2, AKT1, CDH1
regulation of multicellular organismal process (GO:0051239) 1.875BRCA1, PARK2, AKT1, CTNNB1, PIK3CA
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.295BRCA1, CTNNB1, PARK2, AKT1, CDH1
regulation of neuron death (GO:1901214) 4.195PARK2, AKT1, RRAS2, PIK3CA, CTNNB1
establishment of localization (GO:0051234) 1.485CDH1, AKT1, PARK2, PIK3CA, CTNNB1
localization (GO:0051179) 1.45CDH1, AKT1, PARK2, PIK3CA, CTNNB1
single-organism localization (GO:1902578) 2.095CTNNB1, PARK2, AKT1, CDH1, PIK3CA
primary metabolic process (GO:0044238) 0.695BRCA1, PARK2, AKT1, CTNNB1, PIK3CA
regulation of cellular protein metabolic process (GO:0032268) 1.995PARK2, BRCA1, AKT1, PIK3CA, CTNNB1
single-multicellular organism process (GO:0044707) 1.785AKT1, BRCA1, PARK2, PIK3CA, CTNNB1
protein metabolic process (GO:0019538) 1.455PARK2, BRCA1, AKT1, PIK3CA, CTNNB1
cellular response to organic cyclic compound (GO:0071407) 3.935BRCA1, CTNNB1, PARK2, AKT1, CDH1
response to organonitrogen compound (GO:0010243) 3.25AKT1, BRCA1, PARK2, CDH1, CTNNB1
positive regulation of protein modification process (GO:0031401) 2.75AKT1, BRCA1, PARK2, PIK3CA, CTNNB1
positive regulation of RNA metabolic process (GO:0051254) 2.515BRCA1, CTNNB1, PARK2, AKT1, CDH1
cellular metabolic process (GO:0044237) 0.695PARK2, BRCA1, AKT1, CTNNB1, PIK3CA
macromolecule metabolic process (GO:0043170) 0.835BRCA1, PARK2, AKT1, CTNNB1, PIK3CA
positive regulation of RNA biosynthetic process (GO:1902680) 2.545PARK2, BRCA1, AKT1, CTNNB1, CDH1
regulation of transcription, DNA-templated (GO:0006355) 1.565BRCA1, CTNNB1, PARK2, AKT1, CDH1
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.395CDH1, BRCA1, PARK2, AKT1, CTNNB1
regulation of macromolecule biosynthetic process (GO:0010556) 1.435CDH1, BRCA1, PARK2, AKT1, CTNNB1
regulation of RNA metabolic process (GO:0051252) 1.525BRCA1, CTNNB1, PARK2, AKT1, CDH1
positive regulation of cellular component organization (GO:0051130) 2.685SEPT9, BRCA1, PARK2, AKT1, CTNNB1
response to nitrogen compound (GO:1901698) 3.125AKT1, BRCA1, PARK2, CDH1, CTNNB1
negative regulation of apoptotic signaling pathway (GO:2001234) 4.424BRCA1, PARK2, AKT1, CTNNB1
protein localization (GO:0008104) 2.364CTNNB1, PARK2, AKT1, CDH1
regulation of phosphate metabolic process (GO:0019220) 2.354PARK2, AKT1, CTNNB1, PIK3CA
regulation of apoptotic signaling pathway (GO:2001233) 3.834BRCA1, PARK2, CTNNB1, AKT1
regulation of cell adhesion (GO:0030155) 3.274CDH1, AKT1, PIK3CA, CTNNB1
negative regulation of cellular metabolic process (GO:0031324) 2.014BRCA1, PARK2, AKT1, CTNNB1
negative regulation of cellular component organization (GO:0051129) 3.354BRCA1, PARK2, AKT1, CTNNB1
homeostatic process (GO:0042592) 2.614PARK2, AKT1, CTNNB1, PIK3CA
regulation of cell-cell adhesion (GO:0022407) 3.794CTNNB1, AKT1, CDH1, PIK3CA
negative regulation of gene expression (GO:0010629) 2.484BRCA1, PARK2, AKT1, CTNNB1
cellular component assembly (GO:0022607) 2.144SEPT9, PARK2, CDH1, CTNNB1
nitrogen compound metabolic process (GO:0006807) 1.134BRCA1, PARK2, CTNNB1, AKT1
negative regulation of cell communication (GO:0010648) 2.664BRCA1, PARK2, AKT1, CTNNB1
cellular macromolecule biosynthetic process (GO:0034645) 1.664BRCA1, PARK2, CTNNB1, AKT1
negative regulation of metabolic process (GO:0009892) 1.934BRCA1, PARK2, AKT1, CTNNB1
intracellular signal transduction (GO:0035556) 2.394BRCA1, RRAS2, AKT1, PIK3CA
cellular protein metabolic process (GO:0044267) 1.634BRCA1, PARK2, AKT1, PIK3CA
single-organism metabolic process (GO:0044710) 1.634BRCA1, PARK2, PIK3CA, AKT1
negative regulation of macromolecule metabolic process (GO:0010605) 2.014BRCA1, PARK2, AKT1, CTNNB1
negative regulation of signal transduction (GO:0009968) 2.754BRCA1, PARK2, AKT1, CTNNB1
positive regulation of multicellular organismal process (GO:0051240) 2.494BRCA1, PARK2, AKT1, CTNNB1
regulation of anatomical structure morphogenesis (GO:0022603) 2.794BRCA1, PARK2, SEPT9, CTNNB1
positive regulation of molecular function (GO:0044093) 2.234PARK2, AKT1, CTNNB1, PIK3CA
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.814BRCA1, PARK2, AKT1, CTNNB1
regulation of molecular function (GO:0065009) 1.784PARK2, AKT1, PIK3CA, CTNNB1
regulation of biological quality (GO:0065008) 1.684PARK2, AKT1, CTNNB1, PIK3CA
negative regulation of response to stimulus (GO:0048585) 2.524BRCA1, PARK2, AKT1, CTNNB1
organelle organization (GO:0006996) 2.024BRCA1, PARK2, AKT1, PIK3CA
regulation of establishment of protein localization (GO:0070201) 3.024BRCA1, PARK2, CDH1, AKT1
regulation of catalytic activity (GO:0050790) 1.974PARK2, AKT1, CTNNB1, PIK3CA
regulation of DNA metabolic process (GO:0051052) 3.874BRCA1, AKT1, CTNNB1, PIK3CA
positive regulation of transport (GO:0051050) 2.94BRCA1, PARK2, AKT1, CDH1
transport (GO:0006810) 1.514PARK2, AKT1, CTNNB1, PIK3CA
regulation of transferase activity (GO:0051338) 2.884PARK2, AKT1, CTNNB1, PIK3CA
negative regulation of protein metabolic process (GO:0051248) 2.824BRCA1, PARK2, AKT1, CTNNB1
cellular protein modification process (GO:0006464) 1.794BRCA1, PARK2, PIK3CA, AKT1
regulation of phosphorus metabolic process (GO:0051174) 2.354PARK2, AKT1, CTNNB1, PIK3CA
macromolecule modification (GO:0043412) 1.734BRCA1, PARK2, PIK3CA, AKT1
protein modification process (GO:0036211) 1.794BRCA1, PARK2, AKT1, PIK3CA
cellular component disassembly (GO:0022411) 3.524CTNNB1, PARK2, PIK3CA, CDH1
cellular nitrogen compound metabolic process (GO:0034641) 1.224BRCA1, PARK2, CTNNB1, AKT1
negative regulation of neuron death (GO:1901215) 4.574PARK2, AKT1, PIK3CA, CTNNB1
cellular localization (GO:0051641) 2.324CTNNB1, PARK2, AKT1, CDH1
regulation of phosphorylation (GO:0042325) 2.54PARK2, AKT1, CTNNB1, PIK3CA
negative regulation of cellular protein metabolic process (GO:0032269) 2.884BRCA1, PARK2, AKT1, CTNNB1
macromolecule localization (GO:0033036) 2.344CTNNB1, PARK2, AKT1, CDH1
cellular nitrogen compound biosynthetic process (GO:0044271) 1.594BRCA1, PARK2, AKT1, CTNNB1
response to external stimulus (GO:0009605) 2.554BRCA1, PARK2, CTNNB1, AKT1
positive regulation of developmental process (GO:0051094) 2.774BRCA1, PARK2, SEPT9, CTNNB1
negative regulation of protein modification process (GO:0031400) 3.44BRCA1, PARK2, AKT1, CTNNB1
positive regulation of organelle organization (GO:0010638) 3.384BRCA1, PARK2, SEPT9, CTNNB1
single-organism transport (GO:0044765) 2.184PARK2, AKT1, CTNNB1, PIK3CA
macromolecule biosynthetic process (GO:0009059) 1.614BRCA1, PARK2, AKT1, CTNNB1
regulation of cellular component biogenesis (GO:0044087) 3.084BRCA1, PARK2, SEPT9, CTNNB1
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.244BRCA1, PARK2, CTNNB1, AKT1
regulation of multicellular organismal development (GO:2000026) 2.314BRCA1, PARK2, AKT1, CTNNB1
system development (GO:0048731) 2.924PARK2, AKT1, CTNNB1, PIK3CA
regulation of protein phosphorylation (GO:0001932) 2.574PARK2, AKT1, CTNNB1, PIK3CA
negative regulation of signaling (GO:0023057) 2.654BRCA1, PARK2, AKT1, CTNNB1
regulation of intracellular protein transport (GO:0033157) 3.83BRCA1, PARK2, CDH1
regulation of intracellular transport (GO:0032386) 3.583BRCA1, PARK2, CDH1
regulation of neuron apoptotic process (GO:0043523) 4.473PARK2, PIK3CA, CTNNB1
small molecule metabolic process (GO:0044281) 2.383BRCA1, PIK3CA, AKT1
cell surface receptor signaling pathway (GO:0007166) 2.093AKT1, CTNNB1, PIK3CA
organic cyclic compound biosynthetic process (GO:1901362) 1.663BRCA1, PARK2, CTNNB1
regulation of cell projection organization (GO:0031344) 3.383PARK2, SEPT9, AKT1
organic cyclic compound metabolic process (GO:1901360) 1.263BRCA1, PARK2, CTNNB1
single-organism biosynthetic process (GO:0044711) 2.83BRCA1, PIK3CA, AKT1
response to indole-3-methanol (GO:0071680) 8.123BRCA1, CDH1, CTNNB1
cellular response to indole-3-methanol (GO:0071681) 8.123BRCA1, CTNNB1, CDH1
cellular macromolecule localization (GO:0070727) 3.13PARK2, CTNNB1, CDH1
cellular developmental process (GO:0048869) 1.823RRAS2, AKT1, CTNNB1
protein modification by small protein conjugation or removal (GO:0070647) 2.953BRCA1, PARK2, AKT1
protein modification by small protein conjugation (GO:0032446) 3.13BRCA1, PARK2, AKT1
regulation of signal transduction by p53 class mediator (GO:1901796) 4.633BRCA1, PARK2, AKT1
heterocycle metabolic process (GO:0046483) 1.313BRCA1, PARK2, CTNNB1
regulation of cell proliferation (GO:0042127) 2.413BRCA1, AKT1, CTNNB1
positive regulation of DNA metabolic process (GO:0051054) 4.493BRCA1, AKT1, CTNNB1
establishment of protein localization (GO:0045184) 2.533CTNNB1, AKT1, CDH1
regulation of cell activation (GO:0050865) 3.533AKT1, PIK3CA, CTNNB1
protein catabolic process (GO:0030163) 3.933PARK2, AKT1, CTNNB1
response to metal ion (GO:0010038) 3.913PARK2, CDH1, CTNNB1
response to inorganic substance (GO:0010035) 3.563PARK2, CDH1, CTNNB1
system process (GO:0003008) 2.33PARK2, AKT1, PIK3CA
positive regulation of phosphorylation (GO:0042327) 2.93AKT1, PIK3CA, CTNNB1
negative regulation of organelle organization (GO:0010639) 4.073BRCA1, PARK2, AKT1
chemical homeostasis (GO:0048878) 2.973PARK2, PIK3CA, AKT1
immune system process (GO:0002376) 2.293AKT1, PIK3CA, CTNNB1
protein ubiquitination (GO:0016567) 3.283BRCA1, PARK2, AKT1
cellular response to stress (GO:0033554) 2.513BRCA1, PARK2, AKT1
aromatic compound biosynthetic process (GO:0019438) 1.73BRCA1, PARK2, CTNNB1
regulation of cell morphogenesis (GO:0022604) 3.43PARK2, SEPT9, CTNNB1
negative regulation of biosynthetic process (GO:0009890) 2.473BRCA1, PARK2, CTNNB1
regulation of protein transport (GO:0051223) 3.123BRCA1, PARK2, CDH1
nucleic acid-templated transcription (GO:0097659) 1.913BRCA1, PARK2, CTNNB1
organic substance catabolic process (GO:1901575) 2.453PARK2, AKT1, CTNNB1
positive regulation of transferase activity (GO:0051347) 3.313AKT1, CTNNB1, PIK3CA
regulation of kinase activity (GO:0043549) 3.073PARK2, PIK3CA, AKT1
macromolecular complex assembly (GO:0065003) 2.553PARK2, SEPT9, CTNNB1
regulation of immune system process (GO:0002682) 2.53AKT1, PIK3CA, CTNNB1
mitochondrion organization (GO:0007005) 3.693PARK2, PIK3CA, AKT1
heterocycle biosynthetic process (GO:0018130) 1.73BRCA1, PARK2, CTNNB1
cellular protein localization (GO:0034613) 3.113PARK2, CDH1, CTNNB1
response to cytokine (GO:0034097) 3.843BRCA1, AKT1, CTNNB1
regulation of neurogenesis (GO:0050767) 3.213PARK2, AKT1, CTNNB1
regulation of reactive oxygen species metabolic process (GO:2000377) 4.713BRCA1, PARK2, AKT1
cell activation (GO:0001775) 3.473AKT1, PIK3CA, CTNNB1
nucleobase-containing compound biosynthetic process (GO:0034654) 1.723BRCA1, PARK2, CTNNB1
RNA metabolic process (GO:0016070) 1.593BRCA1, PARK2, CTNNB1
regulation of protein localization to nucleus (GO:1900180) 4.343BRCA1, AKT1, CDH1
positive regulation of protein localization to nucleus (GO:1900182) 4.873BRCA1, AKT1, CDH1
regulation of response to stress (GO:0080134) 2.533BRCA1, PARK2, AKT1
regulation of cellular response to stress (GO:0080135) 3.43BRCA1, PARK2, AKT1
response to stress (GO:0006950) 1.83BRCA1, PARK2, AKT1
regulation of leukocyte activation (GO:0002694) 3.63AKT1, CTNNB1, PIK3CA
regulation of nervous system development (GO:0051960) 3.13PARK2, AKT1, CTNNB1
transcription, DNA-templated (GO:0006351) 1.913BRCA1, PARK2, CTNNB1
positive regulation of signal transduction (GO:0009967) 2.53PARK2, AKT1, CTNNB1
response to alcohol (GO:0097305) 4.583BRCA1, CDH1, CTNNB1
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.533BRCA1, PARK2, CTNNB1
cellular response to alcohol (GO:0097306) 6.073BRCA1, CDH1, CTNNB1
cellular response to metal ion (GO:0071248) 4.813PARK2, CTNNB1, CDH1
RNA biosynthetic process (GO:0032774) 1.843BRCA1, PARK2, CTNNB1
regulation of cytoskeleton organization (GO:0051493) 3.723BRCA1, PARK2, CTNNB1
cell differentiation (GO:0030154) 2.143RRAS2, AKT1, CTNNB1
cellular response to inorganic substance (GO:0071241) 4.673PARK2, CDH1, CTNNB1
positive regulation of signaling (GO:0023056) 2.413PARK2, AKT1, CTNNB1
regulation of protein targeting (GO:1903533) 4.03BRCA1, PARK2, CDH1
positive regulation of cell communication (GO:0010647) 2.413PARK2, AKT1, CTNNB1
positive regulation of establishment of protein localization (GO:1904951) 3.493BRCA1, CDH1, AKT1
positive regulation of catalytic activity (GO:0043085) 2.43AKT1, PIK3CA, CTNNB1
regulation of MAPK cascade (GO:0043408) 3.223PARK2, AKT1, CTNNB1
nucleobase-containing compound metabolic process (GO:0006139) 1.353BRCA1, PARK2, CTNNB1
regulation of lymphocyte activation (GO:0051249) 3.733AKT1, PIK3CA, CTNNB1
positive regulation of phosphorus metabolic process (GO:0010562) 2.783AKT1, CTNNB1, PIK3CA
regulation of cell cycle process (GO:0010564) 3.53BRCA1, CTNNB1, AKT1
regulation of cell development (GO:0060284) 3.013PARK2, AKT1, CTNNB1
regulation of protein modification by small protein conjugation or removal (GO:1903320) 4.143BRCA1, PARK2, CTNNB1
macromolecular complex subunit organization (GO:0043933) 2.143PARK2, SEPT9, CTNNB1
biological adhesion (GO:0022610) 2.813OPCML, CTNNB1, CDH1
regulation of leukocyte cell-cell adhesion (GO:1903037) 4.013AKT1, PIK3CA, CTNNB1
cellular aromatic compound metabolic process (GO:0006725) 1.33BRCA1, PARK2, CTNNB1
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.713BRCA1, PARK2, CTNNB1
positive regulation of cell differentiation (GO:0045597) 3.013PARK2, AKT1, CTNNB1
regulation of cell differentiation (GO:0045595) 2.423PARK2, AKT1, CTNNB1
negative regulation of transcription, DNA-templated (GO:0045892) 2.753BRCA1, PARK2, CTNNB1
negative regulation of RNA metabolic process (GO:0051253) 2.663BRCA1, PARK2, CTNNB1
gland development (GO:0048732) 4.153CTNNB1, PIK3CA, CDH1
negative regulation of cellular biosynthetic process (GO:0031327) 2.493BRCA1, PARK2, CTNNB1
regulation of T cell activation (GO:0050863) 4.053AKT1, CTNNB1, PIK3CA
nucleic acid metabolic process (GO:0090304) 1.463BRCA1, PARK2, CTNNB1
positive regulation of cell death (GO:0010942) 3.323PARK2, AKT1, CTNNB1
multicellular organism development (GO:0007275) 2.543BRCA1, CTNNB1, AKT1
protein complex subunit organization (GO:0071822) 2.63PARK2, SEPT9, CTNNB1
positive regulation of cellular protein localization (GO:1903829) 3.853BRCA1, CDH1, AKT1
regulation of growth (GO:0040008) 3.263PARK2, PIK3CA, AKT1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.63BRCA1, PARK2, CTNNB1
positive regulation of apoptotic process (GO:0043065) 3.383PARK2, AKT1, CTNNB1
organic substance transport (GO:0071702) 2.153PARK2, AKT1, CTNNB1
positive regulation of programmed cell death (GO:0043068) 3.383PARK2, AKT1, CTNNB1
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.553BRCA1, PARK2, CTNNB1
positive regulation of phosphate metabolic process (GO:0045937) 2.783AKT1, PIK3CA, CTNNB1
protein complex assembly (GO:0006461) 2.783PARK2, SEPT9, CTNNB1
negative regulation of RNA biosynthetic process (GO:1902679) 2.73BRCA1, PARK2, CTNNB1
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.473BRCA1, PARK2, CTNNB1
establishment of localization in cell (GO:0051649) 2.473PARK2, AKT1, CTNNB1
cell adhesion (GO:0007155) 2.823OPCML, CDH1, CTNNB1
catabolic process (GO:0009056) 2.383PARK2, AKT1, CTNNB1
macromolecule catabolic process (GO:0009057) 3.03PARK2, AKT1, CTNNB1
response to abiotic stimulus (GO:0009628) 2.83BRCA1, AKT1, CTNNB1
regulation of cell cycle (GO:0051726) 2.933BRCA1, AKT1, CTNNB1
positive regulation of protein phosphorylation (GO:0001934) 2.953AKT1, CTNNB1, PIK3CA
regulation of extrinsic apoptotic signaling pathway (GO:2001236) 4.692BRCA1, AKT1
negative regulation of extrinsic apoptotic signaling pathway (GO:2001237) 5.132BRCA1, AKT1
positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436) 5.472PARK2, AKT1
regulation of neuron projection development (GO:0010975) 3.692PARK2, AKT1
regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032434) 5.052PARK2, AKT1
anatomical structure homeostasis (GO:0060249) 4.252PARK2, CTNNB1
cell development (GO:0048468) 3.282AKT1, CTNNB1
carbohydrate homeostasis (GO:0033500) 4.62AKT1, PIK3CA
mitophagy in response to mitochondrial depolarization (GO:0098779) 4.852PARK2, PIK3CA
membrane organization (GO:0061024) 3.042AKT1, CDH1
plasma membrane organization (GO:0007009) 4.82AKT1, CDH1
negative regulation of neuron apoptotic process (GO:0043524) 4.822PARK2, PIK3CA
positive regulation of neuron apoptotic process (GO:0043525) 5.882PARK2, CTNNB1
regulation of histone H3-K4 methylation (GO:0051569) 6.362BRCA1, CTNNB1
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242PIK3CA, AKT1
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.542PIK3CA, AKT1
cell surface receptor signaling pathway involved in cell-cell signaling (GO:1905114) 3.792AKT1, CTNNB1
positive regulation of cell projection organization (GO:0031346) 3.992PARK2, SEPT9
hormone-mediated signaling pathway (GO:0009755) 4.662BRCA1, CTNNB1
negative regulation of cell cycle (GO:0045786) 3.672BRCA1, CTNNB1
positive regulation of cell cycle (GO:0045787) 3.942BRCA1, AKT1
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175) 6.362PARK2, AKT1
positive regulation of cell adhesion (GO:0045785) 3.792PIK3CA, AKT1
regulation of mitochondrion organization (GO:0010821) 4.342PARK2, AKT1
negative regulation of cytoskeleton organization (GO:0051494) 5.012BRCA1, PARK2
positive regulation of neuron death (GO:1901216) 5.522PARK2, CTNNB1
regulation of gene expression, epigenetic (GO:0040029) 4.582BRCA1, CTNNB1
peptidyl-amino acid modification (GO:0018193) 2.982BRCA1, AKT1
regulation of neuron differentiation (GO:0045664) 3.392PARK2, AKT1
negative regulation of lipid metabolic process (GO:0045833) 5.332BRCA1, AKT1
regulation of metal ion transport (GO:0010959) 3.942AKT1, CTNNB1
negative regulation of oxidative stress-induced cell death (GO:1903202) 6.232PARK2, AKT1
positive regulation of cell development (GO:0010720) 3.572PARK2, CTNNB1
epithelial cell differentiation (GO:0030855) 3.982AKT1, CTNNB1
(GO:1905269) 5.252BRCA1, CTNNB1
lymphocyte costimulation (GO:0031294) 5.332AKT1, PIK3CA
cellular homeostasis (GO:0019725) 3.232PARK2, PIK3CA
protein oligomerization (GO:0051259) 3.712SEPT9, CTNNB1
negative regulation of transport (GO:0051051) 3.62PARK2, AKT1
protein polyubiquitination (GO:0000209) 4.232BRCA1, PARK2
response to drug (GO:0042493) 3.712CDH1, CTNNB1
regulation of protein kinase activity (GO:0045859) 3.152PIK3CA, AKT1
protein heterooligomerization (GO:0051291) 5.222SEPT9, CTNNB1
germ cell development (GO:0007281) 4.752AKT1, CTNNB1
developmental process involved in reproduction (GO:0003006) 3.362AKT1, CTNNB1
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) 3.832AKT1, CTNNB1
regulation of proteolysis (GO:0030162) 3.22PARK2, AKT1
positive regulation of histone methylation (GO:0031062) 6.22BRCA1, CTNNB1
intracellular steroid hormone receptor signaling pathway (GO:0030518) 5.472BRCA1, CTNNB1
cellular response to growth factor stimulus (GO:0071363) 4.272AKT1, CTNNB1
response to peptide hormone (GO:0043434) 4.062AKT1, CTNNB1
platelet activation (GO:0030168) 4.962PIK3CA, AKT1
cellular response to lithium ion (GO:0071285) 6.92CDH1, CTNNB1
single organism signaling (GO:0044700) 3.252PARK2, CTNNB1
single organism reproductive process (GO:0044702) 2.732AKT1, CTNNB1
organonitrogen compound metabolic process (GO:1901564) 2.322PARK2, AKT1
vesicle-mediated transport (GO:0016192) 2.722PIK3CA, CTNNB1
cell motility (GO:0048870) 3.022PIK3CA, CTNNB1
response to nutrient levels (GO:0031667) 3.772BRCA1, AKT1
regulation of proteasomal protein catabolic process (GO:0061136) 4.782PARK2, AKT1
protein autoubiquitination (GO:0051865) 5.842BRCA1, PARK2
response to hormone (GO:0009725) 3.332AKT1, CTNNB1
regulation of protein import (GO:1904589) 4.522BRCA1, CDH1
regulation of microtubule cytoskeleton organization (GO:0070507) 4.982BRCA1, CTNNB1
cell communication (GO:0007154) 3.042PARK2, CTNNB1
negative regulation of kinase activity (GO:0033673) 4.222PARK2, AKT1
regulation of catabolic process (GO:0009894) 3.522PARK2, AKT1
positive regulation of kinase activity (GO:0033674) 3.542PIK3CA, AKT1
embryonic organ development (GO:0048568) 4.862AKT1, CTNNB1
positive regulation of catabolic process (GO:0009896) 3.942PARK2, AKT1
regulation of histone modification (GO:0031056) 4.852BRCA1, CTNNB1
regulation of DNA binding (GO:0051101) 5.212PARK2, CTNNB1
organelle disassembly (GO:1903008) 4.522PARK2, PIK3CA
movement of cell or subcellular component (GO:0006928) 2.612PIK3CA, CTNNB1
regulation of glucose metabolic process (GO:0010906) 5.082PARK2, AKT1
response to radiation (GO:0009314) 3.692BRCA1, AKT1
regulation of vasculature development (GO:1901342) 4.262BRCA1, CTNNB1
regulation of cell migration (GO:0030334) 3.232RRAS2, AKT1
regulation of DNA methylation (GO:0044030) 6.782BRCA1, PIK3CA
negative regulation of JNK cascade (GO:0046329) 6.232PARK2, AKT1
regulation of JNK cascade (GO:0046328) 4.652PARK2, AKT1
positive regulation of protein transport (GO:0051222) 3.612BRCA1, CDH1
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123) 4.542PARK2, CTNNB1
positive regulation of intracellular transport (GO:0032388) 4.082BRCA1, CDH1
regulation of mitotic cell cycle (GO:0007346) 3.712AKT1, CTNNB1
cellular macromolecule catabolic process (GO:0044265) 3.192PARK2, CTNNB1
regulation of fatty acid metabolic process (GO:0019217) 5.252BRCA1, AKT1
intracellular protein transport (GO:0006886) 3.22AKT1, CTNNB1
negative regulation of phosphate metabolic process (GO:0045936) 3.452PARK2, AKT1
regulation of cellular component movement (GO:0051270) 3.082RRAS2, AKT1
positive regulation of immune system process (GO:0002684) 2.962PIK3CA, AKT1
anterograde trans-synaptic signaling (GO:0098916) 3.982PARK2, CTNNB1
cell cycle (GO:0007049) 3.142BRCA1, SEPT9
positive regulation of proteasomal protein catabolic process (GO:1901800) 5.292PARK2, AKT1
cellular response to abiotic stimulus (GO:0071214) 4.152AKT1, CTNNB1
anatomical structure formation involved in morphogenesis (GO:0048646) 3.012PIK3CA, CTNNB1
protein K6-linked ubiquitination (GO:0085020) 7.652BRCA1, PARK2
negative regulation of reactive oxygen species metabolic process (GO:2000378) 5.992BRCA1, PARK2
single organism cell adhesion (GO:0098602) 3.632CTNNB1, CDH1
regulation of release of cytochrome c from mitochondria (GO:0090199) 5.942PARK2, AKT1
lipid metabolic process (GO:0006629) 2.682BRCA1, PIK3CA
cell-cell adhesion (GO:0098609) 3.342CTNNB1, CDH1
hexose metabolic process (GO:0019318) 4.642PIK3CA, AKT1
phosphorylation (GO:0016310) 2.632AKT1, PIK3CA
tissue development (GO:0009888) 3.272PIK3CA, CTNNB1
positive regulation of intracellular protein transport (GO:0090316) 4.192BRCA1, CDH1
programmed cell death (GO:0012501) 3.12BRCA1, AKT1
single-organism membrane organization (GO:0044802) 3.192AKT1, CDH1
negative regulation of transferase activity (GO:0051348) 3.872PARK2, AKT1
negative regulation of intracellular signal transduction (GO:1902532) 3.632PARK2, AKT1
positive regulation of intracellular signal transduction (GO:1902533) 2.952PARK2, CTNNB1
regulation of lipid transport (GO:0032368) 5.212PARK2, AKT1
inositol lipid-mediated signaling (GO:0048017) 4.912AKT1, PIK3CA
proteolysis involved in cellular protein catabolic process (GO:0051603) 3.592PARK2, CTNNB1
muscle cell differentiation (GO:0042692) 5.092AKT1, CTNNB1
intracellular transport (GO:0046907) 2.672AKT1, CTNNB1
cellular response to cytokine stimulus (GO:0071345) 4.332BRCA1, AKT1
protein kinase B signaling (GO:0043491) 6.22PIK3CA, AKT1
response to lithium ion (GO:0010226) 6.432CTNNB1, CDH1
proteasomal protein catabolic process (GO:0010498) 4.122PARK2, CTNNB1
regulation of myelination (GO:0031641) 6.232AKT1, CTNNB1
positive regulation of protein catabolic process (GO:0045732) 4.182PARK2, AKT1
positive regulation of nucleocytoplasmic transport (GO:0046824) 4.932BRCA1, CDH1
positive regulation of leukocyte activation (GO:0002696) 4.02AKT1, PIK3CA
regulation of nucleocytoplasmic transport (GO:0046822) 4.332BRCA1, CDH1
positive regulation of cell motility (GO:2000147) 3.742RRAS2, AKT1
nervous system development (GO:0007399) 3.532AKT1, CTNNB1
positive regulation of chromosome organization (GO:2001252) 4.762BRCA1, CTNNB1
synaptic signaling (GO:0099536) 3.982PARK2, CTNNB1
trans-synaptic signaling (GO:0099537) 3.982PARK2, CTNNB1
regulation of chromosome organization (GO:0033044) 4.112BRCA1, CTNNB1
regulation of developmental growth (GO:0048638) 4.042PARK2, PIK3CA
synapse organization (GO:0050808) 4.872CDH1, CTNNB1
positive regulation of cell growth (GO:0030307) 4.732PARK2, AKT1
chemical synaptic transmission (GO:0007268) 3.982PARK2, CTNNB1
negative regulation of release of cytochrome c from mitochondria (GO:0090201) 6.92PARK2, AKT1
response to growth factor (GO:0070848) 4.142AKT1, CTNNB1
cellular catabolic process (GO:0044248) 2.622PARK2, CTNNB1
embryo development (GO:0009790) 4.22BRCA1, CTNNB1
regulation of protein catabolic process (GO:0042176) 3.832PARK2, AKT1
embryo development ending in birth or egg hatching (GO:0009792) 4.352BRCA1, CTNNB1
signaling (GO:0023052) 3.252PARK2, CTNNB1
ERBB signaling pathway (GO:0038127) 5.362PIK3CA, AKT1
steroid hormone mediated signaling pathway (GO:0043401) 4.92BRCA1, CTNNB1
regulation of protein import into nucleus (GO:0042306) 4.542BRCA1, CDH1
chordate embryonic development (GO:0043009) 4.382BRCA1, CTNNB1
regulation of microtubule-based process (GO:0032886) 4.792BRCA1, CTNNB1
ERBB2 signaling pathway (GO:0038128) 6.092PIK3CA, AKT1
response to mechanical stimulus (GO:0009612) 4.412AKT1, CTNNB1
negative regulation of catalytic activity (GO:0043086) 3.02PARK2, AKT1
negative regulation of MAPK cascade (GO:0043409) 4.742PARK2, AKT1
negative regulation of phosphorylation (GO:0042326) 3.72PARK2, AKT1
cellular response to peptide hormone stimulus (GO:0071375) 4.632AKT1, CTNNB1
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122PARK2, CTNNB1
proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161) 4.162PARK2, CTNNB1
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122) 4.272PARK2, CTNNB1
vasculature development (GO:0001944) 6.042PIK3CA, CTNNB1
regulation of cellular ketone metabolic process (GO:0010565) 4.672BRCA1, AKT1
positive regulation of neurogenesis (GO:0050769) 3.772PARK2, CTNNB1
positive regulation of leukocyte cell-cell adhesion (GO:1903039) 4.352PIK3CA, AKT1
positive regulation of protein modification by small protein conjugation or removal (GO:1903322) 4.482BRCA1, PARK2
positive regulation of protein import (GO:1904591) 5.082BRCA1, CDH1
positive regulation of protein ubiquitination (GO:0031398) 4.552BRCA1, PARK2
regulation of peptidyl-serine phosphorylation (GO:0033135) 4.982PIK3CA, AKT1
regulation of protein ubiquitination (GO:0031396) 4.222BRCA1, PARK2
proteolysis (GO:0006508) 2.732PARK2, CTNNB1
positive regulation of protein import into nucleus (GO:0042307) 5.112BRCA1, CDH1
cellular response to mechanical stimulus (GO:0071260) 5.332AKT1, CTNNB1
negative regulation of intrinsic apoptotic signaling pathway (GO:2001243) 5.212PARK2, AKT1
regulation of intrinsic apoptotic signaling pathway (GO:2001242) 4.742PARK2, AKT1
positive regulation of cell proliferation (GO:0008284) 3.012AKT1, CTNNB1
insulin receptor signaling pathway (GO:0008286) 5.332PIK3CA, AKT1
cellular response to external stimulus (GO:0071496) 4.22AKT1, CTNNB1
reproductive structure development (GO:0048608) 4.082AKT1, CTNNB1
regulation of oxidative stress-induced cell death (GO:1903201) 5.92PARK2, AKT1
cell proliferation (GO:0008283) 3.232AKT1, CTNNB1
positive regulation of proteolysis involved in cellular protein catabolic process (GO:1903052) 4.62PARK2, AKT1
establishment of protein localization to organelle (GO:0072594) 3.922AKT1, CTNNB1
regulation of proteolysis involved in cellular protein catabolic process (GO:1903050) 4.322PARK2, AKT1
negative regulation of molecular function (GO:0044092) 2.742PARK2, AKT1
modification-dependent protein catabolic process (GO:0019941) 3.712PARK2, CTNNB1
positive regulation of T cell activation (GO:0050870) 4.392PIK3CA, AKT1
cellular response to DNA damage stimulus (GO:0006974) 3.172BRCA1, AKT1
negative regulation of stress-activated MAPK cascade (GO:0032873) 6.022PARK2, AKT1
negative regulation of fatty acid metabolic process (GO:0045922) 6.332BRCA1, AKT1
regulation of cell growth (GO:0001558) 3.752PARK2, AKT1
regulation of cellular carbohydrate metabolic process (GO:0010675) 4.812PARK2, AKT1
cell-cell junction organization (GO:0045216) 4.662CTNNB1, CDH1
cellular lipid metabolic process (GO:0044255) 2.922BRCA1, PIK3CA
regulation of phosphatidylinositol 3-kinase signaling (GO:0014066) 4.792AKT1, PIK3CA
response to oxidative stress (GO:0006979) 3.92PARK2, AKT1
negative regulation of developmental process (GO:0051093) 3.172PARK2, CTNNB1
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091) 4.292AKT1, CTNNB1
regulation of cellular response to oxidative stress (GO:1900407) 5.722PARK2, AKT1
regulation of epithelial cell proliferation (GO:0050678) 4.062AKT1, CTNNB1
positive regulation of epithelial cell proliferation (GO:0050679) 4.672AKT1, CTNNB1
mitophagy (GO:0000422) 4.632PARK2, PIK3CA
macromitophagy (GO:0000423) 4.852PARK2, PIK3CA
positive regulation of lymphocyte activation (GO:0051251) 4.072AKT1, PIK3CA
monosaccharide metabolic process (GO:0005996) 4.572PIK3CA, AKT1
regulation of binding (GO:0051098) 4.082PARK2, CTNNB1
negative regulation of cellular response to oxidative stress (GO:1900408) 6.232PARK2, AKT1
negative regulation of stress-activated protein kinase signaling cascade (GO:0070303) 6.022PARK2, AKT1
regulation of cytokine production (GO:0001817) 3.42BRCA1, CTNNB1
T cell costimulation (GO:0031295) 5.352AKT1, PIK3CA
regulation of ion transport (GO:0043269) 3.42AKT1, CTNNB1
protein localization to organelle (GO:0033365) 3.572PARK2, CTNNB1
positive regulation of proteolysis (GO:0045862) 3.862PARK2, AKT1
glucose metabolic process (GO:0006006) 4.942PIK3CA, AKT1
positive regulation of protein kinase activity (GO:0045860) 3.612PIK3CA, AKT1
positive regulation of cytokine production (GO:0001819) 3.822BRCA1, CTNNB1
regulation of chromatin organization (GO:1902275) 4.692BRCA1, CTNNB1
response to extracellular stimulus (GO:0009991) 3.712BRCA1, AKT1
positive regulation of peptidyl-serine phosphorylation (GO:0033138) 5.262AKT1, PIK3CA
positive regulation of growth (GO:0045927) 4.252PARK2, AKT1
regulation of cellular catabolic process (GO:0031329) 3.832PARK2, AKT1
cell projection organization (GO:0030030) 3.142AKT1, CDH1
adherens junction organization (GO:0034332) 5.482CTNNB1, CDH1
positive regulation of cell activation (GO:0050867) 3.972PIK3CA, AKT1
cell junction organization (GO:0034330) 4.512CTNNB1, CDH1
macroautophagy (GO:0016236) 4.32PARK2, PIK3CA
glucose homeostasis (GO:0042593) 4.62PIK3CA, AKT1
liver development (GO:0001889) 4.982PIK3CA, CTNNB1
cell migration (GO:0016477) 3.122PIK3CA, CTNNB1
negative regulation of mitochondrion organization (GO:0010823) 6.072PARK2, AKT1
regulation of lipid biosynthetic process (GO:0046890) 4.872BRCA1, AKT1
modification-dependent macromolecule catabolic process (GO:0043632) 3.692PARK2, CTNNB1
single-organism carbohydrate metabolic process (GO:0044723) 3.422AKT1, PIK3CA
cell death (GO:0008219) 3.052BRCA1, AKT1
osteoblast differentiation (GO:0001649) 5.052RRAS2, AKT1
positive regulation of cell-cell adhesion (GO:0022409) 4.232PIK3CA, AKT1
response to estradiol (GO:0032355) 4.732BRCA1, CTNNB1
intracellular receptor signaling pathway (GO:0030522) 4.62BRCA1, CTNNB1
regulation of generation of precursor metabolites and energy (GO:0043467) 5.242PIK3CA, AKT1
positive regulation of nervous system development (GO:0051962) 3.642PARK2, CTNNB1
response to lipid (GO:0033993) 3.112BRCA1, CTNNB1
response to toxic substance (GO:0009636) 4.882PARK2, CDH1
regulation of angiogenesis (GO:0045765) 4.362BRCA1, CTNNB1
phosphate-containing compound metabolic process (GO:0006796) 2.162PIK3CA, AKT1
regulation of stress-activated protein kinase signaling cascade (GO:0070302) 4.442PARK2, AKT1
ubiquitin-dependent protein catabolic process (GO:0006511) 3.722PARK2, CTNNB1
phosphatidylinositol-mediated signaling (GO:0048015) 4.932PIK3CA, AKT1
regulation of organelle assembly (GO:1902115) 4.72BRCA1, SEPT9
positive regulation of cellular catabolic process (GO:0031331) 4.152PARK2, AKT1
regulation of cell motility (GO:2000145) 3.162RRAS2, AKT1
regulation of autophagy (GO:0010506) 4.212PARK2, AKT1
single organismal cell-cell adhesion (GO:0016337) 3.692CDH1, CTNNB1
positive regulation of cellular protein catabolic process (GO:1903364) 4.522PARK2, AKT1
protein phosphorylation (GO:0006468) 2.892PIK3CA, AKT1
positive regulation of cell migration (GO:0030335) 3.772RRAS2, AKT1
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176) 6.682PARK2, AKT1
regulation of cellular protein catabolic process (GO:1903362) 4.232PARK2, AKT1
regulation of lipid metabolic process (GO:0019216) 4.082BRCA1, AKT1
mitochondrion disassembly (GO:0061726) 4.632PARK2, PIK3CA
cell-cell signaling (GO:0007267) 3.352PARK2, CTNNB1
autophagy (GO:0006914) 3.822PARK2, PIK3CA
apoptotic process (GO:0006915) 3.142BRCA1, AKT1
regulation of oxidoreductase activity (GO:0051341) 5.272PARK2, AKT1
regulation of stress-activated MAPK cascade (GO:0032872) 4.452PARK2, AKT1
reproductive process (GO:0022414) 2.552AKT1, CTNNB1
positive regulation of histone modification (GO:0031058) 5.322BRCA1, CTNNB1
cellular process involved in reproduction in multicellular organism (GO:0022412) 4.32AKT1, CTNNB1
response to estrogen (GO:0043627) 5.252BRCA1, CTNNB1
positive regulation of histone H3-K4 methylation (GO:0051571) 6.92BRCA1, CTNNB1
regulation of response to oxidative stress (GO:1902882) 5.622PARK2, AKT1
negative regulation of response to oxidative stress (GO:1902883) 6.232PARK2, AKT1
lipid biosynthetic process (GO:0008610) 3.492BRCA1, PIK3CA
locomotion (GO:0040011) 2.912PIK3CA, CTNNB1
positive regulation of cellular component movement (GO:0051272) 3.712RRAS2, AKT1
regulation of locomotion (GO:0040012) 3.122RRAS2, AKT1
carbohydrate metabolic process (GO:0005975) 3.262PIK3CA, AKT1
positive regulation of locomotion (GO:0040017) 3.712RRAS2, AKT1
regulation of carbohydrate metabolic process (GO:0006109) 4.572PARK2, AKT1
androgen receptor signaling pathway (GO:0030521) 6.022BRCA1, CTNNB1
cellular response to hormone stimulus (GO:0032870) 3.992AKT1, CTNNB1
single-organism organelle organization (GO:1902589) 2.682PARK2, PIK3CA
response to peptide (GO:1901652) 3.942AKT1, CTNNB1
cellular response to peptide (GO:1901653) 4.522AKT1, CTNNB1
phosphorus metabolic process (GO:0006793) 2.152PIK3CA, AKT1
protein transport (GO:0015031) 2.622AKT1, CTNNB1
regulation of histone methylation (GO:0031060) 5.652BRCA1, CTNNB1
negative regulation of protein phosphorylation (GO:0001933) 3.792PARK2, AKT1
single-organism cellular localization (GO:1902580) 3.162CDH1, CTNNB1
negative regulation of phosphorus metabolic process (GO:0010563) 3.452PARK2, AKT1
positive regulation of cellular component biogenesis (GO:0044089) 3.712SEPT9, CTNNB1

NET-GE enrichment

Term New enriched termICP valueGenes
negative regulation of apoptotic signaling pathway (GO:2001234) -4.420.001BRCA1, CTNNB1, PARK2, AKT1, CDH1
limb morphogenesis (GO:0035108) NEW5.050.028BRCA1, AKT1, CDH1, CTNNB1
organophosphate catabolic process (GO:0046434) NEW5.030.012CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
regulation of apoptotic signaling pathway (GO:2001233) -3.830.02CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
positive regulation of reproductive process (GO:2000243) NEW5.80.03CTNNB1, AKT1, CDH1
appendage morphogenesis (GO:0035107) NEW5.050.028CDH1, BRCA1, AKT1, CTNNB1
male gonad development (GO:0008584) NEW5.080.0CDH1, BRCA1, CTNNB1, AKT1, PIK3CA
nucleotide catabolic process (GO:0009166) NEW5.670.007CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
negative regulation of response to DNA damage stimulus (GO:2001021) NEW5.780.032BRCA1, CDH1, AKT1
regulation of Wnt signaling pathway (GO:0030111) NEW3.980.001CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
purine ribonucleoside catabolic process (GO:0046130) NEW7.160.004CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
signal transduction by phosphorylation (GO:0023014) NEW3.790.011CDH1, BRCA1, AKT1, PIK3CA, CTNNB1
purine ribonucleoside metabolic process (GO:0046128) NEW4.330.018CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
response to indole-3-methanol (GO:0071680) -8.120.0BRCA1, CTNNB1, CDH1
cellular response to indole-3-methanol (GO:0071681) -8.120.0BRCA1, CTNNB1, CDH1
negative regulation of signal transduction (GO:0009968) -2.750.037AKT1, BRCA1, PARK2, CDH1, CTNNB1
positive regulation of cell adhesion (GO:0045785) -3.790.011CDH1, BRCA1, AKT1, PIK3CA, CTNNB1
response to epidermal growth factor (GO:0070849) NEW6.290.019BRCA1, CDH1, AKT1
ribonucleoside triphosphate metabolic process (GO:0009199) NEW4.770.008CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
negative regulation of lipid metabolic process (GO:0045833) -5.330.004BRCA1, AKT1, PIK3CA, CDH1
regulation of myoblast differentiation (GO:0045661) NEW5.860.009CTNNB1, AKT1, CDH1
negative regulation of myoblast differentiation (GO:0045662) NEW6.550.001CDH1, AKT1, CTNNB1
purine ribonucleoside triphosphate catabolic process (GO:0009207) NEW9.730.004CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
purine ribonucleoside triphosphate metabolic process (GO:0009205) NEW4.810.007CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
GTP metabolic process (GO:0046039) NEW6.590.001RRAS2, PARK2, CDH1, SEPT9, AKT1, PIK3CA
muscle contraction (GO:0006936) NEW4.370.014PARK2, AKT1, CDH1, CTNNB1, PIK3CA
T cell differentiation (GO:0030217) NEW5.110.047BRCA1, AKT1, CDH1, CTNNB1
peptidyl-tyrosine dephosphorylation (GO:0035335) NEW5.10.016CTNNB1, PARK2, AKT1, CDH1
regulation of glycoprotein metabolic process (GO:1903018) NEW5.970.025CTNNB1, AKT1, CDH1
neural crest cell migration (GO:0001755) NEW5.760.048CTNNB1, AKT1, CDH1
regulation of response to DNA damage stimulus (GO:2001020) NEW4.740.024BRCA1, AKT1, CTNNB1, CDH1
response to inorganic substance (GO:0010035) -3.560.022CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
ribonucleoside catabolic process (GO:0042454) NEW6.550.005CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
negative regulation of phosphorylation (GO:0042326) -3.70.008CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
organonitrogen compound catabolic process (GO:1901565) NEW3.910.003CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1, BRCA1
response to organonitrogen compound (GO:0010243) -3.20.01CDH1, BRCA1, AKT1, CTNNB1, PIK3CA
nucleoside catabolic process (GO:0009164) NEW6.170.006CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
regulation of DNA replication (GO:0006275) NEW5.020.047BRCA1, AKT1, PIK3CA, CDH1
regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393) NEW5.630.027AKT1, CDH1, CTNNB1
purine nucleotide metabolic process (GO:0006163) NEW4.090.03CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
aromatic compound catabolic process (GO:0019439) NEW3.790.004CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1, BRCA1
regulation of microtubule cytoskeleton organization (GO:0070507) -4.980.012BRCA1, PARK2, CTNNB1, AKT1
regulation of protein localization to cell surface (GO:2000008) NEW6.430.046CDH1, CTNNB1
regulation of canonical Wnt signaling pathway (GO:0060828) NEW4.260.0CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
regulation of mitotic cell cycle phase transition (GO:1901990) NEW4.230.018CDH1, BRCA1, AKT1, PIK3CA, CTNNB1
positive regulation of catabolic process (GO:0009896) -3.940.038PARK2, AKT1, CDH1, CTNNB1, PIK3CA
negative regulation of catabolic process (GO:0009895) NEW4.810.002CTNNB1, PARK2, AKT1, CDH1, PIK3CA
cellular component disassembly involved in execution phase of apoptosis (GO:0006921) NEW6.470.05CTNNB1, AKT1, CDH1
embryonic skeletal system morphogenesis (GO:0048704) NEW5.310.018BRCA1, AKT1, CDH1, CTNNB1
nucleoside triphosphate metabolic process (GO:0009141) NEW4.610.01CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
nucleoside triphosphate catabolic process (GO:0009143) NEW7.240.004CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
purine nucleoside triphosphate metabolic process (GO:0009144) NEW4.760.008CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
regulation of kidney development (GO:0090183) NEW5.720.002CDH1, BRCA1, CTNNB1, AKT1
purine nucleoside triphosphate catabolic process (GO:0009146) NEW7.940.004CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
negative regulation of organelle organization (GO:0010639) -4.070.033OPCML, BRCA1, PARK2, AKT1, CDH1
negative regulation of catenin import into nucleus (GO:0035414) NEW7.430.0CDH1, AKT1, CTNNB1
positive regulation of Wnt signaling pathway (GO:0030177) NEW4.70.024CDH1, BRCA1, AKT1, CTNNB1
embryonic axis specification (GO:0000578) NEW6.360.014CTNNB1, AKT1, CDH1
regulation of catenin import into nucleus (GO:0035412) NEW6.470.0AKT1, CDH1, CTNNB1, PIK3CA
negative regulation of protein serine/threonine kinase activity (GO:0071901) NEW4.920.029BRCA1, PARK2, PIK3CA, AKT1
regulation of protein serine/threonine kinase activity (GO:0071900) NEW3.580.041CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
developmental maturation (GO:0021700) NEW4.70.015CDH1, BRCA1, AKT1, CTNNB1, PIK3CA
regulation of myeloid leukocyte differentiation (GO:0002761) NEW5.020.048CDH1, BRCA1, CTNNB1, AKT1
positive regulation of cell cycle process (GO:0090068) NEW4.250.03BRCA1, CTNNB1, AKT1, PIK3CA, CDH1
positive regulation of myeloid leukocyte differentiation (GO:0002763) NEW5.820.001BRCA1, AKT1, CDH1, CTNNB1
cell morphogenesis (GO:0000902) NEW4.350.031CDH1, BRCA1, AKT1, PIK3CA, CTNNB1
cellular response to tumor necrosis factor (GO:0071356) NEW5.190.022BRCA1, AKT1, PIK3CA, CDH1
regulation of lipid metabolic process (GO:0019216) -4.080.041BRCA1, AKT1, CDH1, CTNNB1, PIK3CA
gonad development (GO:0008406) NEW4.920.002BRCA1, AKT1, CDH1, CTNNB1, PIK3CA
ribonucleotide metabolic process (GO:0009259) NEW4.110.03CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
guanosine-containing compound catabolic process (GO:1901069) NEW8.630.0RRAS2, PARK2, CDH1, SEPT9, AKT1, PIK3CA
guanosine-containing compound metabolic process (GO:1901068) NEW5.90.001RRAS2, PARK2, CDH1, SEPT9, AKT1, PIK3CA
negative regulation of hexokinase activity (GO:1903300) NEW7.940.016PARK2, AKT1
locomotory behavior (GO:0007626) NEW4.530.035CTNNB1, PARK2, AKT1, CDH1, PIK3CA
regulation of heart contraction (GO:0008016) NEW4.350.004PARK2, CTNNB1, AKT1, PIK3CA, CDH1
purine ribonucleotide catabolic process (GO:0009154) NEW6.470.005CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
regulation of nucleocytoplasmic transport (GO:0046822) -4.330.016CDH1, BRCA1, AKT1, CTNNB1, PIK3CA
purine ribonucleotide metabolic process (GO:0009150) NEW4.160.026CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
ribonucleotide catabolic process (GO:0009261) NEW6.430.005CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
regulation of cell cycle phase transition (GO:1901987) NEW4.150.023CDH1, BRCA1, AKT1, CTNNB1, PIK3CA
negative regulation of intracellular signal transduction (GO:1902532) -3.630.0CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, AKT1, BRCA1
negative regulation of cell cycle phase transition (GO:1901988) NEW4.740.003BRCA1, AKT1, CDH1, CTNNB1, PIK3CA
regulation of protein localization to nucleus (GO:1900180) -4.340.008BRCA1, AKT1, CDH1, CTNNB1, PIK3CA
regulation of protein processing (GO:0070613) NEW5.350.009CDH1, PARK2, AKT1, CTNNB1, PIK3CA
dorsal/ventral pattern formation (GO:0009953) NEW5.60.011CDH1, BRCA1, CTNNB1, AKT1
protein maturation (GO:0051604) NEW4.480.021AKT1, CTNNB1, PARK2, PIK3CA, CDH1
negative regulation of multicellular organismal process (GO:0051241) NEW2.840.047CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
response to nitrogen compound (GO:1901698) -3.120.015CDH1, BRCA1, AKT1, PIK3CA, CTNNB1
cellular response to nitrogen compound (GO:1901699) -3.790.001CDH1, BRCA1, AKT1, CTNNB1, PIK3CA
positive regulation of mesenchymal cell proliferation (GO:0002053) NEW6.40.044CTNNB1, AKT1, CDH1
positive regulation of protein catabolic process (GO:0045732) -4.180.041PARK2, AKT1, PIK3CA, CDH1
neuron projection morphogenesis (GO:0048812) NEW4.340.016BRCA1, AKT1, SEPT9, CTNNB1, PIK3CA
positive regulation of protein maturation (GO:1903319) NEW6.840.012AKT1, PARK2, PIK3CA, CDH1
negative regulation of protein maturation (GO:1903318) NEW6.170.008PARK2, AKT1, PIK3CA, CTNNB1
positive regulation of cell motility (GO:2000147) -3.740.006CTNNB1, RRAS2, PARK2, CDH1, PIK3CA, AKT1
regulation of protein maturation (GO:1903317) NEW5.330.009CTNNB1, PARK2, AKT1, CDH1, PIK3CA
purine-containing compound catabolic process (GO:0072523) NEW5.920.006CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
regulation of glycoprotein biosynthetic process (GO:0010559) NEW6.090.014CTNNB1, AKT1, CDH1
cellular response to alcohol (GO:0097306) -6.070.005CDH1, BRCA1, CTNNB1, AKT1
negative regulation of phosphorus metabolic process (GO:0010563) -3.450.023CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
cellular response to metal ion (GO:0071248) -4.810.001CDH1, PARK2, AKT1, PIK3CA, CTNNB1
regulation of receptor internalization (GO:0002090) NEW6.090.04CTNNB1, AKT1, CDH1
negative regulation of release of cytochrome c from mitochondria (GO:0090201) -6.90.032PARK2, AKT1
cellular response to inorganic substance (GO:0071241) -4.670.001CDH1, AKT1, PARK2, PIK3CA, CTNNB1
negative regulation of cellular component organization (GO:0051129) -3.350.008CTNNB1, OPCML, PARK2, CDH1, PIK3CA, AKT1, BRCA1
tube formation (GO:0035148) NEW4.980.048BRCA1, AKT1, CTNNB1, CDH1
post-embryonic development (GO:0009791) NEW5.350.044BRCA1, AKT1, CDH1, CTNNB1
negative regulation of signaling (GO:0023057) -2.650.046CDH1, BRCA1, PARK2, CTNNB1, AKT1
regulation of protein catabolic process (GO:0042176) -3.830.001CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
negative regulation of mitotic cell cycle phase transition (GO:1901991) NEW4.820.002CDH1, BRCA1, CTNNB1, AKT1, PIK3CA
negative regulation of cell communication (GO:0010648) -2.660.046PARK2, BRCA1, AKT1, CDH1, CTNNB1
regulation of protein import into nucleus (GO:0042306) -4.540.005BRCA1, AKT1, CDH1, CTNNB1, PIK3CA
regulation of microtubule-based process (GO:0032886) -4.790.027BRCA1, PARK2, AKT1, CTNNB1
ribonucleoside metabolic process (GO:0009119) NEW4.210.024CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
positive regulation of glycoprotein biosynthetic process (GO:0010560) NEW6.840.001CTNNB1, AKT1, CDH1
positive regulation of multicellular organismal process (GO:0051240) -2.490.018CTNNB1, PARK2, SEPT9, CDH1, PIK3CA, AKT1, BRCA1
purine nucleoside metabolic process (GO:0042278) NEW4.320.019CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
regulation of protein modification by small protein conjugation or removal (GO:1903320) -4.140.005BRCA1, PARK2, CTNNB1, AKT1, PIK3CA
positive regulation of protein modification by small protein conjugation or removal (GO:1903322) -4.480.027BRCA1, PARK2, AKT1, PIK3CA
branching involved in mammary gland duct morphogenesis (GO:0060444) NEW6.780.005CDH1, AKT1, CTNNB1
regulation of morphogenesis of a branching structure (GO:0060688) NEW5.760.002CDH1, BRCA1, AKT1, CTNNB1
central nervous system projection neuron axonogenesis (GO:0021952) NEW6.730.009BRCA1, CTNNB1, AKT1
cellular response to endogenous stimulus (GO:0071495) -3.330.032CDH1, BRCA1, AKT1, PIK3CA, CTNNB1
negative regulation of cell proliferation (GO:0008285) NEW3.260.028CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, AKT1, BRCA1
myotube differentiation involved in skeletal muscle regeneration (GO:0014908) NEW9.040.005AKT1, CTNNB1
cellular response to external stimulus (GO:0071496) -4.20.025CDH1, BRCA1, AKT1, CTNNB1, PIK3CA
cellular response to oxygen-containing compound (GO:1901701) -3.220.012CDH1, BRCA1, AKT1, CTNNB1, PIK3CA
regulation of vesicle-mediated transport (GO:0060627) NEW3.630.012CTNNB1, PARK2, CDH1, SEPT9, AKT1, PIK3CA
signal transduction by p53 class mediator (GO:0072331) NEW4.880.013BRCA1, AKT1, CDH1, CTNNB1
regulation of cellular component movement (GO:0051270) -3.080.019CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, AKT1, BRCA1
protein oligomerization (GO:0051259) -3.710.019CTNNB1, CDH1, SEPT9, AKT1, PIK3CA, BRCA1
cellular response to epidermal growth factor stimulus (GO:0071364) NEW6.470.013BRCA1, CDH1, AKT1
negative regulation of epithelial to mesenchymal transition (GO:0010719) NEW6.590.009AKT1, CDH1, CTNNB1
carbohydrate derivative catabolic process (GO:1901136) NEW4.610.001CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1, BRCA1
negative regulation of cell morphogenesis involved in differentiation (GO:0010771) NEW4.960.044CTNNB1, AKT1, CDH1
positive regulation of proteolysis (GO:0045862) -3.860.007PARK2, AKT1, CDH1, PIK3CA
regulation of exocytosis (GO:0017157) NEW4.590.001CDH1, PARK2, AKT1, PIK3CA, CTNNB1
negative regulation of protein modification process (GO:0031400) -3.40.025CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
response to endoplasmic reticulum stress (GO:0034976) NEW4.460.002CDH1, AKT1, PARK2, PIK3CA, CTNNB1
negative regulation of fatty acid metabolic process (GO:0045922) -6.330.041BRCA1, AKT1
regulation of cellular response to stress (GO:0080135) -3.40.029CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
embryonic limb morphogenesis (GO:0030326) NEW5.240.015BRCA1, AKT1, CTNNB1, CDH1
regulation of peptidyl-serine phosphorylation (GO:0033135) -4.980.021CDH1, AKT1, PIK3CA, CTNNB1
calcium-dependent cell-cell adhesion (GO:0016339) NEW6.40.006CTNNB1, AKT1, CDH1
regulation of DNA methylation (GO:0044030) -6.780.002BRCA1, PIK3CA, AKT1
negative regulation of glucokinase activity (GO:0033132) NEW7.940.016PARK2, AKT1
adherens junction maintenance (GO:0034334) NEW9.730.005AKT1, CTNNB1
regulation of cell-cell adhesion (GO:0022407) -3.790.022CDH1, AKT1, PIK3CA, CTNNB1
negative regulation of cell cycle process (GO:0010948) NEW4.370.019BRCA1, CTNNB1, AKT1, PIK3CA, CDH1
positive regulation of glycoprotein metabolic process (GO:1903020) NEW6.730.001AKT1, CDH1, CTNNB1
fat cell differentiation (GO:0045444) NEW5.020.033CTNNB1, PARK2, AKT1, CDH1
lens development in camera-type eye (GO:0002088) NEW6.090.03BRCA1, AKT1, CTNNB1
ribonucleoside triphosphate catabolic process (GO:0009203) NEW9.730.004CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
cell death (GO:0008219) -3.050.04AKT1, BRCA1, PARK2, CDH1, CTNNB1
regulation of cell death (GO:0010941) -2.430.014CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
cell division (GO:0051301) NEW3.680.001SEPT9, BRCA1, AKT1, CDH1, CTNNB1
positive regulation of cell-cell adhesion (GO:0022409) -4.230.0CDH1, AKT1, PIK3CA, CTNNB1
purine nucleotide catabolic process (GO:0006195) NEW6.070.006CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
regulation of apoptotic process (GO:0042981) -2.50.011CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
cellular response to organonitrogen compound (GO:0071417) -3.870.001CDH1, BRCA1, AKT1, CTNNB1, PIK3CA
regulation of cell adhesion mediated by integrin (GO:0033628) NEW6.040.036AKT1, CDH1, PIK3CA
regulation of programmed cell death (GO:0043067) -2.490.011CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
positive regulation of myeloid cell differentiation (GO:0045639) NEW5.330.007BRCA1, AKT1, CDH1, CTNNB1
purine nucleoside catabolic process (GO:0006152) NEW7.160.004CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
nucleoside phosphate catabolic process (GO:1901292) NEW5.540.007CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
hematopoietic or lymphoid organ development (GO:0048534) NEW4.490.015BRCA1, CTNNB1, AKT1, PIK3CA, CDH1
positive regulation of cell migration (GO:0030335) -3.770.005CTNNB1, RRAS2, PARK2, CDH1, PIK3CA, AKT1
negative regulation of phosphate metabolic process (GO:0045936) -3.450.023CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
regulation of skeletal muscle fiber development (GO:0048742) NEW7.240.024AKT1, CDH1, CTNNB1
regulation of metal ion transport (GO:0010959) -3.940.049CTNNB1, PARK2, AKT1, CDH1, PIK3CA
nucleoside metabolic process (GO:0009116) NEW4.120.028CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
embryonic appendage morphogenesis (GO:0035113) NEW5.240.015CDH1, BRCA1, AKT1, CTNNB1
Ras protein signal transduction (GO:0007265) NEW4.760.002CDH1, RRAS2, AKT1, CTNNB1, PIK3CA
negative regulation of protein processing (GO:0010955) NEW6.170.008PARK2, AKT1, PIK3CA, CTNNB1
positive regulation of protein processing (GO:0010954) NEW6.90.012PARK2, AKT1, PIK3CA, CDH1
tyrosine phosphorylation of STAT protein (GO:0007260) NEW7.330.05AKT1, CDH1
positive regulation of cellular component movement (GO:0051272) -3.710.006CTNNB1, RRAS2, PARK2, CDH1, PIK3CA, AKT1
regulation of locomotion (GO:0040012) -3.120.021CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, AKT1, BRCA1
cell projection morphogenesis (GO:0048858) NEW4.050.049SEPT9, BRCA1, CTNNB1, AKT1, PIK3CA
positive regulation of locomotion (GO:0040017) -3.710.0CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, AKT1, BRCA1
muscle system process (GO:0003012) NEW4.180.045AKT1, CTNNB1, PARK2, PIK3CA, CDH1
ribose phosphate metabolic process (GO:0019693) NEW4.060.031CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
glycosyl compound metabolic process (GO:1901657) NEW4.040.033CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
response to fluid shear stress (GO:0034405) NEW6.20.008AKT1, CDH1, CTNNB1
glycosyl compound catabolic process (GO:1901658) NEW6.020.006CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1
positive regulation of cellular component biogenesis (GO:0044089) -3.710.022BRCA1, AKT1, CDH1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.119CTNNB1, OPCML, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1, BRCA1
intracellular part (GO:0044424) 0.288CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1, BRCA1
cytoplasmic part (GO:0044444) 0.828CTNNB1, RRAS2, PARK2, PIK3CA, CDH1, SEPT9, AKT1, BRCA1
organelle (GO:0043226) 0.48CTNNB1, OPCML, RRAS2, PARK2, SEPT9, CDH1, AKT1, BRCA1
protein complex (GO:0043234) 1.517CTNNB1, PARK2, SEPT9, CDH1, PIK3CA, AKT1, BRCA1
macromolecular complex (GO:0032991) 1.357CTNNB1, PARK2, SEPT9, CDH1, PIK3CA, AKT1, BRCA1
membrane (GO:0016020) 0.687CTNNB1, OPCML, RRAS2, CDH1, PIK3CA, AKT1, BRCA1
intracellular organelle (GO:0043229) 0.517CTNNB1, RRAS2, PARK2, SEPT9, CDH1, AKT1, BRCA1
plasma membrane (GO:0005886) 1.397CTNNB1, OPCML, RRAS2, CDH1, PIK3CA, AKT1, BRCA1
membrane-bounded organelle (GO:0043227) 0.477CTNNB1, OPCML, RRAS2, PARK2, CDH1, AKT1, BRCA1
cytoplasm (GO:0005737) 1.016CTNNB1, PARK2, CDH1, SEPT9, AKT1, BRCA1
intracellular membrane-bounded organelle (GO:0043231) 0.66CTNNB1, RRAS2, PARK2, CDH1, AKT1, BRCA1
vesicle (GO:0031982) 1.645OPCML, CTNNB1, RRAS2, AKT1, CDH1
intracellular non-membrane-bounded organelle (GO:0043232) 1.765SEPT9, BRCA1, AKT1, CDH1, CTNNB1
intracellular organelle part (GO:0044446) 0.815CDH1, SEPT9, BRCA1, CTNNB1, AKT1
non-membrane-bounded organelle (GO:0043228) 1.765CDH1, SEPT9, BRCA1, AKT1, CTNNB1
cytoskeletal part (GO:0044430) 2.495CDH1, BRCA1, AKT1, SEPT9, CTNNB1
membrane part (GO:0044425) 0.955OPCML, BRCA1, CTNNB1, CDH1, PIK3CA
cell projection (GO:0042995) 2.475SEPT9, PARK2, CDH1, CTNNB1, PIK3CA
organelle part (GO:0044422) 0.795SEPT9, BRCA1, AKT1, CDH1, CTNNB1
cytoskeleton (GO:0005856) 2.554SEPT9, AKT1, CDH1, CTNNB1
extracellular vesicle (GO:1903561) 1.894OPCML, RRAS2, CTNNB1, CDH1
extracellular organelle (GO:0043230) 1.894OPCML, RRAS2, CDH1, CTNNB1
extracellular exosome (GO:0070062) 1.894OPCML, RRAS2, CTNNB1, CDH1
cytosol (GO:0005829) 1.684PARK2, AKT1, CTNNB1, PIK3CA
membrane-bounded vesicle (GO:0031988) 1.714OPCML, RRAS2, CTNNB1, CDH1
perinuclear region of cytoplasm (GO:0048471) 3.354SEPT9, PARK2, CTNNB1, CDH1
nucleus (GO:0005634) 1.074BRCA1, PARK2, CTNNB1, AKT1
extracellular region part (GO:0044421) 1.574OPCML, RRAS2, CTNNB1, CDH1
cell junction (GO:0030054) 2.754CDH1, RRAS2, AKT1, CTNNB1
cell projection part (GO:0044463) 2.973SEPT9, AKT1, CTNNB1
cell-cell junction (GO:0005911) 3.853CDH1, AKT1, CTNNB1
catalytic complex (GO:1902494) 2.93BRCA1, PARK2, PIK3CA
lamellipodium (GO:0030027) 4.733CDH1, PIK3CA, CTNNB1
anchoring junction (GO:0070161) 3.613RRAS2, CTNNB1, CDH1
nucleoplasm (GO:0005654) 1.893BRCA1, CTNNB1, AKT1
membrane protein complex (GO:0098796) 2.843CDH1, PIK3CA, CTNNB1
nuclear part (GO:0044428) 1.553BRCA1, AKT1, CTNNB1
adherens junction (GO:0005912) 3.663RRAS2, CDH1, CTNNB1
transferase complex (GO:1990234) 3.323BRCA1, PARK2, PIK3CA
cell-substrate adherens junction (GO:0005924) 3.833RRAS2, CTNNB1, CDH1
focal adhesion (GO:0005925) 3.833RRAS2, CTNNB1, CDH1
intrinsic component of membrane (GO:0031224) 1.133BRCA1, OPCML, CDH1
cell-substrate junction (GO:0030055) 3.823RRAS2, CTNNB1, CDH1
endoplasmic reticulum (GO:0005783) 2.562PARK2, RRAS2
inclusion body (GO:0016234) 5.552PARK2, CDH1
aggresome (GO:0016235) 6.252PARK2, CDH1
catenin complex (GO:0016342) 7.612CTNNB1, CDH1
actin cytoskeleton (GO:0015629) 4.392SEPT9, CDH1
flotillin complex (GO:0016600) 7.612CDH1, CTNNB1
integral component of membrane (GO:0016021) 1.142BRCA1, CDH1
mitochondrion (GO:0005739) 2.422PARK2, AKT1
microtubule organizing center (GO:0005815) 3.422AKT1, CTNNB1
neuron part (GO:0097458) 2.642PARK2, CTNNB1
synapse part (GO:0044456) 3.422PARK2, AKT1
neuron projection (GO:0043005) 3.122PARK2, CTNNB1
plasma membrane part (GO:0044459) 1.952CDH1, CTNNB1
Golgi apparatus (GO:0005794) 2.72PARK2, CDH1
lateral plasma membrane (GO:0016328) 5.892CDH1, CTNNB1
cell-cell adherens junction (GO:0005913) 5.812CTNNB1, CDH1
ubiquitin ligase complex (GO:0000151) 4.232BRCA1, PARK2
intracellular (GO:0005622) 2.372RRAS2, PIK3CA
plasma membrane protein complex (GO:0098797) 3.552CDH1, CTNNB1
ciliary part (GO:0044441) 4.052SEPT9, AKT1
apical junction complex (GO:0043296) 7.42CTNNB1, CDH1
cell cortex part (GO:0044448) 5.012SEPT9, CDH1

NET-GE enrichment

Term New enriched termICP valueGenes
actin cytoskeleton (GO:0015629) -4.390.025SEPT9, CTNNB1, AKT1, CDH1
pigment granule (GO:0048770) NEW5.220.026AKT1, CDH1, CTNNB1
cytoplasmic side of plasma membrane (GO:0009898) NEW6.00.02PARK2, CTNNB1, CDH1
axon (GO:0030424) NEW4.150.041CDH1, PARK2, AKT1, CTNNB1
microvillus (GO:0005902) NEW5.690.026CDH1, AKT1, CTNNB1
side of membrane (GO:0098552) NEW4.220.007CDH1, AKT1, PARK2, PIK3CA, CTNNB1
catenin complex (GO:0016342) -7.610.001CDH1, CTNNB1
Z disc (GO:0030018) NEW5.110.003CDH1, PARK2, AKT1, CTNNB1
apical part of cell (GO:0045177) NEW5.340.002PARK2, AKT1, CDH1, CTNNB1
neuron projection terminus (GO:0044306) NEW5.460.008AKT1, CDH1, CTNNB1
axon terminus (GO:0043679) NEW5.680.004CDH1, AKT1, CTNNB1
nucleolus (GO:0005730) NEW3.060.03CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
cytoplasmic membrane-bounded vesicle (GO:0016023) NEW3.120.002CTNNB1, PARK2, SEPT9, CDH1, PIK3CA, AKT1, BRCA1
cytoplasmic vesicle (GO:0031410) NEW2.870.006CTNNB1, PARK2, SEPT9, CDH1, PIK3CA, AKT1, BRCA1
cytoplasmic vesicle part (GO:0044433) NEW3.410.016CTNNB1, PARK2, CDH1, SEPT9, AKT1, PIK3CA
neuron part (GO:0097458) -2.640.002CTNNB1, OPCML, PARK2, SEPT9, CDH1, PIK3CA, AKT1, BRCA1
perinuclear region of cytoplasm (GO:0048471) -3.350.009SEPT9, PARK2, CTNNB1, CDH1
endosome lumen (GO:0031904) NEW6.540.02PIK3CA, AKT1
lateral plasma membrane (GO:0016328) -5.890.021CDH1, CTNNB1
catalytic complex (GO:1902494) -2.90.03CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
lamellipodium (GO:0030027) -4.730.005CDH1, AKT1, CTNNB1, PIK3CA
cytoplasmic side of membrane (GO:0098562) NEW5.810.005PARK2, CTNNB1, CDH1
axonal growth cone (GO:0044295) NEW6.810.0CTNNB1, AKT1, CDH1
postsynaptic membrane (GO:0045211) NEW4.470.04PARK2, AKT1, CTNNB1, CDH1
spindle (GO:0005819) NEW4.520.005BRCA1, AKT1, CDH1, CTNNB1
cell-cell adherens junction (GO:0005913) -5.810.026CTNNB1, CDH1
inclusion body (GO:0016234) -5.550.03PARK2, CDH1
transferase complex (GO:1990234) -3.320.003CTNNB1, PARK2, CDH1, PIK3CA, AKT1, BRCA1
plasma membrane (GO:0005886) -1.390.046CTNNB1, OPCML, RRAS2, CDH1, PIK3CA, AKT1, BRCA1
aggresome (GO:0016235) -6.250.006PARK2, CDH1
melanosome (GO:0042470) NEW5.220.026CTNNB1, AKT1, CDH1
dendritic shaft (GO:0043198) NEW6.160.004PARK2, AKT1, CTNNB1
trans-Golgi network (GO:0005802) NEW4.920.002CTNNB1, AKT1, PIK3CA, CDH1
ubiquitin ligase complex (GO:0000151) -4.230.003BRCA1, PARK2, CDH1, CTNNB1
extracellular matrix (GO:0031012) NEW3.810.008BRCA1, AKT1, CTNNB1, CDH1, PIK3CA
cytosolic part (GO:0044445) NEW4.340.004BRCA1, AKT1, CTNNB1, PIK3CA
axon part (GO:0033267) NEW4.40.02CTNNB1, PARK2, AKT1, CDH1
proteinaceous extracellular matrix (GO:0005578) NEW4.010.003CDH1, BRCA1, AKT1, CTNNB1, PIK3CA
contractile fiber part (GO:0044449) NEW4.530.023CTNNB1, PARK2, AKT1, CDH1