Gene | Associated with ESTROGEN RESISTANCE in | Link to HGNC | Cytogenetic band | Number of associated diseases | Associated diseases |
---|---|---|---|---|---|
CCDC170 | ClinVar | HGNC link | 6q25.1 | 1 | 615363 |
ESR1 | ClinVar, OMIM, HUMSAVAR | HGNC link | 6q25.1 | 4 | 608446, 157300, 615363, 114480 |
Download the disease annotation in CSV format
Shared sub_band | Number of genes associated with the disease | Genes associated with the disease |
---|---|---|
6q25.1 | 2 | ESR1, CCDC170 |
Shared band | Number of genes associated with the disease | Genes associated with the disease |
---|---|---|
6q25 | 2 | ESR1, CCDC170 |
Shared region | Number of genes associated with the disease | Genes associated with the disease |
---|---|---|
6q2 | 2 | ESR1, CCDC170 |
TF | associated to this disease | # regulated genes | Regulated genes | # regulated genes associated with this disease | Regulated genes associated with this disease |
---|---|---|---|---|---|
ESR1 | YES | 68 | UGT2B15, AR, PELP1, EGFR, FLT1, RET, AVP, NRF1, CDK4, SERPINE1, PGR, FOS, VEGFA, CHAT, RUNX2, ZFHX3, CYP19A1, SERPINB9, TYMS, DCT, CXCL12, PTMA, HTRA2, NR5A2, CD24, HSPB1, CYP1B1, CTNNB1, MMP13, BRCA1, CYP2C19, BLM, OXT, TAC3, CCNA2, ZEB1, CDKN1A, STAT5A, TERT, MDM2, PMAIP1, CYP1A1, RARA, TP53, JUN, CDH1, AMH, CRHBP, MYC, TFF1, E2F1, CRH, KDR, BTG2, BCL2, UGT1A4, TGFA, KRT19, F12, FOXP1, ESRRA, GREB1, CTSD, JUNB, ESR1, YWHAQ, CCND1, CDKN1B | 1 | ESR1 |
regulated gene | associated to this disease | # TFs | TFs | # TFs associated with this disease | TFs associated with this disease |
---|---|---|---|---|---|
ESR1 | YES | 27 | MECP2, RUNX2, TWIST1, TFAP2C, PGR, HDAC9, NCOR1, SP1, NKX3-1, ARNT, ID4, HDAC7, MTA1, BRCA1, BARX2, XBP1, STAT5A, LEF1, KDM4B, HDAC1, BARD1, STAT5B, PIAS3, TP53, GATA3, NR2E3, ESR1 | 1 | ESR1 |
Gene1 | Gene2 | Direct Interaction | Number of shared interactors | Shared genes in interaction |
---|---|---|---|---|
CCDC170 | ESR1 | No | 1 | CCNH |
Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)
GO | IC | Number of genes with the same GO | Genes |
---|---|---|---|
binding (GO:0005488) | 0.18 | 2 | ESR1, CCDC170 |
protein binding (GO:0005515) | 0.46 | 2 | ESR1, CCDC170 |