Disease table of MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO OMIM ID: 608446

Gene-disease associations table

Gene	Associated with MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
ITGB3	OMIM	HGNC link	17q21.32	2	608446, PS231200
GCLM	OMIM	HGNC link	1p22.1	1	608446
OLR1	OMIM	HGNC link	12p13.2	1	608446
ACE	OMIM	HGNC link	17q23.3	5	PS603933, 608446, 267430, 614519, 104300
F7	OMIM	HGNC link	13q34	2	608446, 227500
LRP8	OMIM	HGNC link	1p32.3	1	608446
ESR1	OMIM	HGNC link	6q25.1	4	608446, 157300, 615363, 114480
GCLC	OMIM	HGNC link	6p12.1	2	608446, 230450
MIAT	OMIM	HGNC link	22q12.1	1	608446
LTA	OMIM	HGNC link	6p21.33	3	608446, 610988, 607507
PSMA6	OMIM	HGNC link	14q13.2	1	608446
LGALS2	OMIM	HGNC link	22q13.1	1	608446
F13A1	OMIM	HGNC link	6p25.1	3	608446, 613225, PS188050
TNFSF4	OMIM	HGNC link	1q25.1	1	608446

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
17q2	2	ITGB3, ACE
22q1	2	LGALS2, MIAT
6p2	2	F13A1, LTA

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
1p	2	GCLM, LRP8
6p	3	LTA, F13A1, GCLC
22q	2	LGALS2, MIAT
17q	2	ITGB3, ACE

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
17	2	ITGB3, ACE
22	2	LGALS2, MIAT
1	3	GCLM, LRP8, TNFSF4
6	4	ESR1, LTA, F13A1, GCLC

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
ESR1	YES	68	UGT2B15, AR, PELP1, EGFR, FLT1, RET, AVP, NRF1, CDK4, SERPINE1, PGR, FOS, VEGFA, CHAT, RUNX2, ZFHX3, CYP19A1, SERPINB9, TYMS, DCT, CXCL12, PTMA, HTRA2, NR5A2, CD24, HSPB1, CYP1B1, CTNNB1, MMP13, BRCA1, CYP2C19, BLM, OXT, TAC3, CCNA2, ZEB1, CDKN1A, STAT5A, TERT, MDM2, PMAIP1, CYP1A1, RARA, TP53, JUN, CDH1, AMH, CRHBP, MYC, TFF1, E2F1, CRH, KDR, BTG2, BCL2, UGT1A4, TGFA, KRT19, F12, FOXP1, ESRRA, GREB1, CTSD, JUNB, ESR1, YWHAQ, CCND1, CDKN1B	1	ESR1
JUND	NO	34	ITGB3, IVL, MDM2, SOX4, NOS2, FOSL1, MYB, NQO1, GAST, SFTPD, PTGS2, IL5, BCL6, CCL5, PLAT, IL6, NTS, CLU, ERBB2, TGFB1, FGFBP1, CDKN1A, F3, CCR4, TIMP1, CD40LG, ITGAV, PLAUR, NQO2, GADD45A, IL3, GCLC, CSTA, CCND1	2	ITGB3, GCLC
ETS1	NO	90	PF4, ITGB3, TP53, TBXAS1, GABRE, PTHLH, TNFSF14, CD14, IGFBP1, BAX, SLC26A3, IL2, MGAT5, VWF, HPGD, CA9, MMP3, MMP9, CSF3R, IL2RB, TERT, THY1, FLT1, FGFBP1, CSF2, MYB, FLI1, ANGPT2, GP6, EGR1, TMEM158, CSNK2B, ERG, SQSTM1, WAS, F13A1, CD8A, MMP1, TGFBR2, ABCB1, ATXN2, NDRG1, SPRY2, HSPB8, BMP4, PRL, TBXA2R, CDKN2A, CHUK, NKX3-1, TAF12, MUC4, HSPE1, TRB, AXIN1, BRCA1, LCK, MMP10, SPP1, RHOC, ICAM1, ANPEP, CSNK2A1, IL5, CR1, HSPA6, HMOX1, CASP1, MDM2, PLAU, SNAI1, TFAP2A, CTSB, TRA, CXCR4, ECE1, SRD5A1, HSPA1L, DUSP6, CDKN1A, FOXD1, GRPR, CTGF, PARP1, TNC, HSPA8, IL3, COL1A1, MMP13, CD6	2	ITGB3, F13A1
FOSL1	NO	9	ITGB3, ITGAV, PLAUR, EZH2, CLU, GCLC, IVL, MMP1, SFTPD	2	ITGB3, GCLC
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	2	GCLC, OLR1
RELA	NO	302	NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC6	2	GCLC, OLR1
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	4	ITGB3, GCLC, ESR1, F7

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
ITGB3	YES	6	SP1, HOXA10, HOXD3, FOSL1, JUND, ETS1	0
OLR1	YES	3	HR, NFKB1, RELA	0
ACE	YES	4	SP3, HIF1A, CREM, EGR1	0
F7	YES	1	SP1	0
ESR1	YES	27	MECP2, RUNX2, TWIST1, TFAP2C, PGR, HDAC9, NCOR1, SP1, NKX3-1, ARNT, ID4, HDAC7, MTA1, BRCA1, BARX2, XBP1, STAT5A, LEF1, KDM4B, HDAC1, BARD1, STAT5B, PIAS3, TP53, GATA3, NR2E3, ESR1	1	ESR1
GCLC	YES	10	SP1, NFKB1, NFE2, FOSL1, NFE2L2, JUN, RELA, JUND, MAF, MTF1	0
LTA	YES	1	MSC	0
F13A1	YES	2	GATA1, ETS1	0
TNFSF4	YES	1	HDAC11	0

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
ITGB3	ESR1	No	3	FLNA, FLNB, P4HB
ITGB3	F13A1	No	1	PTK2
GCLM	ESR1	No	5	CALM1, GNAI2, EGFR, CUL3, OTUB1
GCLM	GCLC	Yes	0
OLR1	GCLC	No	1	ELAVL1
ACE	ESR1	No	3	EWSR1, ACTB, MYH9
F7	LRP8	No	1	ALB
F7	ESR1	No	3	FUS, UIMC1, VCP
F7	PSMA6	No	1	VCP
LRP8	ESR1	No	1	RAD51
ESR1	GCLC	No	1	PPID
ESR1	PSMA6	No	15	XBP1, CDK2, VCP, CCND1, PSMC5, PSMB9, HNRNPA2B1, RBX1, POLR2A, HSPB1, COPS5, PSMD1, ACTN4, BRCA1, CUL1
ESR1	LGALS2	No	1	TUBB
ESR1	F13A1	No	2	CDKN1A, NUDT21
GCLC	PSMA6	No	1	PAXIP1
LTA	LGALS2	Yes	1	TUBA1B
PSMA6	F13A1	No	1	FN1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
ITGB3	OLR1	No	-	2	AKT1, CCL2
ITGB3	F7	No	-	1	VWF
ITGB3	LRP8	No	-	4	SDC1, ITGA3, SDC4, ITGB1
ITGB3	ESR1	No	-	16	HSP90AA1, AKT1, MAPK1, IGF1R, MAPK3, PIK3CA, PIK3R1, SOS1, IGF1, RHOA, SRC, IRS1, SHC1, VEGFA, MAP3K1, BCAR1
ITGB3	PSMA6	No	-	1	CDKN1B
ITGB3	F13A1	No	-	11	ITGA9, FGA, FN1, VWF, ITGB1, FGG, SERPINE1, FGB, IGF1, VEGFA, ITGA4
GCLM	GCLC	Yes	expression, binding	0
OLR1	ACE	No	-	1	NOS3
OLR1	F7	No	-	1	APOB
OLR1	LRP8	No	-	1	APOB
OLR1	ESR1	No	-	4	NOS3, HSPA4, RAC3, AKT1
OLR1	TNFSF4	Yes	activation	0
ACE	ESR1	No	-	1	NOS3
F7	LRP8	No	-	1	APOB
F7	F13A1	No	-	2	F5, VWF
LRP8	ESR1	No	-	2	APBB1, ABL1
LRP8	F13A1	No	-	1	ITGB1
ESR1	GCLC	No	-	2	INS, SUMO1
ESR1	PSMA6	No	-	6	CDKN1A, CCND1, PSMC5, COPS5, UBC, AXIN2
ESR1	F13A1	No	-	4	F2, ALDOA, VEGFA, IGF1
PSMA6	F13A1	No	-	3	ACTN2, ACTN4, ACTN1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
ITGB3	ESR1	No	-	1	SRC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
ITGB3	ESR1	No	1	FN1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Complement and coagulation cascades	hsa04610	6.58	2	F7, F13A1
Proteoglycans in cancer	hsa05205	5.02	2	ITGB3, ESR1
Metabolic pathways	hsa01100	2.49	2	GCLC, GCLM
Glutathione metabolism	hsa00480	6.96	2	GCLC, GCLM
Hypertrophic cardiomyopathy (HCM)	hsa05410	6.21	2	ITGB3, ACE
Phagosome	hsa04145	5.27	2	ITGB3, OLR1
Thyroid hormone signaling pathway	hsa04919	5.82	2	ITGB3, ESR1
Cytokine-cytokine receptor interaction	hsa04060	4.67	2	TNFSF4, LTA

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Hemostasis	R-HSA-109582	3.98	5	ITGB3, F13A1, OLR1, LRP8, F7
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	4	TNFSF4, ITGB3, PSMA6, LTA
Immune System	R-HSA-168256	2.37	4	TNFSF4, ITGB3, PSMA6, LTA
Signal Transduction	R-HSA-162582	1.78	4	ITGB3, ESR1, PSMA6, LRP8
Signaling by ERBB4	R-HSA-1236394	4.7	3	ITGB3, ESR1, PSMA6
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	6.4	3	TNFSF4, PSMA6, LTA
Metabolism	R-HSA-1430728	2.34	3	GCLC, PSMA6, GCLM
Metabolism of amino acids and derivatives	R-HSA-71291	5.4	3	GCLC, PSMA6, GCLM
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85	2	ITGB3, PSMA6
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26	2	ITGB3, PSMA6
NCAM signaling for neurite out-growth	R-HSA-375165	4.9	2	ITGB3, PSMA6
Platelet degranulation	R-HSA-114608	6.68	2	ITGB3, F13A1
Signaling by Interleukins	R-HSA-449147	4.71	2	ITGB3, PSMA6
Biological oxidations	R-HSA-211859	5.55	2	GCLC, GCLM
Interleukin-2 signaling	R-HSA-451927	5.05	2	ITGB3, PSMA6
Frs2-mediated activation	R-HSA-170968	5.12	2	ITGB3, PSMA6
Cell surface interactions at the vascular wall	R-HSA-202733	6.32	2	ITGB3, OLR1
Glutathione synthesis and recycling	R-HSA-174403	9.52	2	GCLC, GCLM
SOS-mediated signalling	R-HSA-112412	5.15	2	ITGB3, PSMA6
IGF1R signaling cascade	R-HSA-2428924	4.85	2	ITGB3, PSMA6
Downstream signal transduction	R-HSA-186763	4.65	2	ITGB3, PSMA6
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85	2	ITGB3, PSMA6
ARMS-mediated activation	R-HSA-170984	5.12	2	ITGB3, PSMA6
Signaling by Insulin receptor	R-HSA-74752	4.73	2	ITGB3, PSMA6
Developmental Biology	R-HSA-1266738	3.48	2	ITGB3, PSMA6
RAF/MAP kinase cascade	R-HSA-5673001	5.15	2	ITGB3, PSMA6
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71	2	ITGB3, PSMA6
MAPK family signaling cascades	R-HSA-5683057	4.89	2	ITGB3, PSMA6
Signalling by NGF	R-HSA-166520	4.23	2	ITGB3, PSMA6
Signaling by VEGF	R-HSA-194138	4.66	2	ITGB3, PSMA6
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12	2	ITGB3, PSMA6
Platelet activation, signaling and aggregation	R-HSA-76002	5.15	2	ITGB3, F13A1
FCERI mediated MAPK activation	R-HSA-2871796	4.32	2	ITGB3, PSMA6
Glutathione conjugation	R-HSA-156590	7.98	2	GCLC, GCLM
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	6.59	2	ITGB3, F13A1
IRS-mediated signalling	R-HSA-112399	4.87	2	ITGB3, PSMA6
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14	2	ITGB3, PSMA6
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14	2	ITGB3, PSMA6
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14	2	ITGB3, PSMA6
Disease	R-HSA-1643685	3.33	2	GCLC, PSMA6
Sulfur amino acid metabolism	R-HSA-1614635	8.46	2	GCLC, GCLM
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71	2	ITGB3, PSMA6
Insulin receptor signalling cascade	R-HSA-74751	4.85	2	ITGB3, PSMA6
Signaling by FGFR4	R-HSA-5654743	4.69	2	ITGB3, PSMA6
Signaling by FGFR3	R-HSA-5654741	4.69	2	ITGB3, PSMA6
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	2	ITGB3, PSMA6
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15	2	ITGB3, PSMA6
Signaling by FGFR	R-HSA-190236	4.67	2	ITGB3, PSMA6
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03	2	ITGB3, PSMA6
Signaling by Leptin	R-HSA-2586552	5.1	2	ITGB3, PSMA6
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11	2	ITGB3, PSMA6
Interleukin receptor SHC signaling	R-HSA-912526	5.09	2	ITGB3, PSMA6
Innate Immune System	R-HSA-168249	3.17	2	ITGB3, PSMA6
Signaling by SCF-KIT	R-HSA-1433557	4.73	2	ITGB3, PSMA6
Metabolism of proteins	R-HSA-392499	3.41	2	F7, ACE
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15	2	ITGB3, PSMA6
Signaling by ERBB2	R-HSA-1227986	4.66	2	ITGB3, PSMA6
Signalling to RAS	R-HSA-167044	5.08	2	ITGB3, PSMA6
DAP12 signaling	R-HSA-2424491	4.64	2	ITGB3, PSMA6
SHC1 events in EGFR signaling	R-HSA-180336	5.15	2	ITGB3, PSMA6
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99	2	ITGB3, PSMA6
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71	2	ITGB3, PSMA6
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15	2	ITGB3, PSMA6
TNFs bind their physiological receptors	R-HSA-5669034	8.34	2	TNFSF4, LTA
Signaling by EGFR	R-HSA-177929	4.59	2	ITGB3, PSMA6
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51	2	ITGB3, PSMA6
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14	2	ITGB3, PSMA6
Prolonged ERK activation events	R-HSA-169893	5.11	2	ITGB3, PSMA6
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	7.7	2	F7, F13A1
Signaling by GPCR	R-HSA-372790	2.68	2	ITGB3, PSMA6
Signaling by FGFR2	R-HSA-5654738	4.68	2	ITGB3, PSMA6
GRB2 events in EGFR signaling	R-HSA-179812	5.15	2	ITGB3, PSMA6
Signalling to ERKs	R-HSA-187687	5.04	2	ITGB3, PSMA6
Signaling by FGFR1	R-HSA-5654736	4.69	2	ITGB3, PSMA6
Phase II conjugation	R-HSA-156580	6.52	2	GCLC, GCLM
DAP12 interactions	R-HSA-2172127	4.56	2	ITGB3, PSMA6
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71	2	ITGB3, PSMA6
Signaling by PDGF	R-HSA-186797	4.53	2	ITGB3, PSMA6
Axon guidance	R-HSA-422475	3.93	2	ITGB3, PSMA6
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07	2	ITGB3, PSMA6
Gene Expression	R-HSA-74160	2.72	2	ESR1, PSMA6

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Glutathione synthesis and recycling (R-HSA-174403)	-	9.52	0.023	GCLC, GCLM

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	13	ITGB3, GCLM, LTA, OLR1, F13A1, F7, PSMA6, GCLC, ACE, ESR1, TNFSF4, LGALS2, LRP8
protein binding (GO:0005515)	0.46	12	ITGB3, GCLM, LTA, OLR1, F7, PSMA6, GCLC, ACE, ESR1, TNFSF4, LGALS2, LRP8
catalytic activity (GO:0003824)	1.05	7	ITGB3, F13A1, F7, PSMA6, GCLC, GCLM, ACE
cation binding (GO:0043169)	1.4	6	F7, F13A1, GCLC, ACE, ESR1, LRP8
receptor binding (GO:0005102)	2.43	6	ITGB3, ESR1, LTA, F7, TNFSF4, ACE
metal ion binding (GO:0046872)	1.41	6	F7, F13A1, GCLC, ACE, ESR1, LRP8
ion binding (GO:0043167)	1.36	6	F7, F13A1, GCLC, ACE, ESR1, LRP8
molecular transducer activity (GO:0060089)	2.32	4	ITGB3, ESR1, OLR1, LRP8
receptor activity (GO:0004872)	2.32	4	ITGB3, ESR1, OLR1, LRP8
enzyme binding (GO:0019899)	2.27	4	ITGB3, ESR1, ACE, GCLM
cytokine receptor binding (GO:0005126)	4.14	3	ITGB3, TNFSF4, LTA
hydrolase activity (GO:0016787)	1.9	3	F7, ACE, PSMA6
endopeptidase activity (GO:0004175)	3.63	3	F7, ACE, PSMA6
signaling receptor activity (GO:0038023)	2.49	3	ITGB3, ESR1, LRP8
carbohydrate derivative binding (GO:0097367)	2.03	3	LGALS2, GCLC, F7
organic cyclic compound binding (GO:0097159)	1.05	3	GCLC, ESR1, PSMA6
peptidase activity, acting on L-amino acid peptides (GO:0070011)	3.26	3	F7, ACE, PSMA6
signal transducer activity (GO:0004871)	2.28	3	ITGB3, ESR1, LRP8
peptidase activity (GO:0008233)	3.23	3	F7, ACE, PSMA6
heterocyclic compound binding (GO:1901363)	1.06	3	GCLC, ESR1, PSMA6
cytokine activity (GO:0005125)	4.34	2	TNFSF4, LTA
lipoprotein particle receptor activity (GO:0030228)	6.97	2	OLR1, LRP8
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	2	GCLC, PSMA6
carbohydrate binding (GO:0030246)	4.17	2	LGALS2, OLR1
tumor necrosis factor receptor binding (GO:0005164)	6.3	2	TNFSF4, LTA
acid-amino acid ligase activity (GO:0016881)	6.69	2	GCLC, GCLM
cargo receptor activity (GO:0038024)	5.53	2	OLR1, LRP8
macromolecular complex binding (GO:0044877)	2.61	2	ESR1, LRP8
zinc ion binding (GO:0008270)	2.66	2	ESR1, ACE
nucleic acid binding (GO:0003676)	1.44	2	ESR1, PSMA6
G-protein coupled receptor binding (GO:0001664)	4.18	2	ESR1, ACE
molecular function regulator (GO:0098772)	2.51	2	ESR1, GCLM
nucleoside phosphate binding (GO:1901265)	1.96	2	GCLC, PSMA6
serine-type peptidase activity (GO:0008236)	4.27	2	F7, ACE
anion binding (GO:0043168)	4.17	2	GCLC, ACE
transition metal ion binding (GO:0046914)	2.48	2	ESR1, ACE
calcium ion binding (GO:0005509)	3.17	2	F7, LRP8
enzyme regulator activity (GO:0030234)	2.85	2	ESR1, GCLM
identical protein binding (GO:0042802)	2.63	2	ITGB3, ESR1
tumor necrosis factor receptor superfamily binding (GO:0032813)	5.89	2	TNFSF4, LTA
serine hydrolase activity (GO:0017171)	4.26	2	F7, ACE
transcription factor binding (GO:0008134)	3.46	2	ESR1, PSMA6
ligase activity, forming carbon-nitrogen bonds (GO:0016879)	5.7	2	GCLC, GCLM
ligase activity (GO:0016874)	3.72	2	GCLC, GCLM
cytoskeletal protein binding (GO:0008092)	3.02	2	ACE, LRP8
glutamate-cysteine ligase activity (GO:0004357)	9.05	2	GCLC, GCLM
low-density lipoprotein receptor activity (GO:0005041)	7.17	2	OLR1, LRP8
protein dimerization activity (GO:0046983)	2.72	2	GCLC, GCLM
protein heterodimerization activity (GO:0046982)	3.64	2	GCLC, GCLM

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
cytokine receptor binding (GO:0005126)	-	4.14	0.021	TNFSF4, ITGB3, F13A1, ESR1, LTA
lipoprotein particle receptor activity (GO:0030228)	-	6.97	0.006	OLR1, LRP8
growth factor receptor binding (GO:0070851)	NEW	4.87	0.014	ITGB3, F13A1, ESR1, ACE
carbohydrate derivative binding (GO:0097367)	-	2.03	0.031	ITGB3, LTA, OLR1, F13A1, F7, PSMA6, GCLC, ACE, ESR1, LGALS2, LRP8
tumor necrosis factor receptor binding (GO:0005164)	-	6.3	0.032	TNFSF4, LTA
enzyme binding (GO:0019899)	-	2.27	0.01	ITGB3, GCLM, LTA, F13A1, F7, PSMA6, GCLC, ACE, ESR1, LRP8

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	12	ITGB3, GCLM, LTA, OLR1, F13A1, F7, PSMA6, GCLC, ACE, ESR1, TNFSF4, LRP8
single-organism process (GO:0044699)	0.48	12	ITGB3, ESR1, LTA, OLR1, F13A1, F7, PSMA6, GCLC, ACE, GCLM, TNFSF4, LRP8
biological regulation (GO:0065007)	0.39	11	ITGB3, GCLM, LTA, F13A1, F7, PSMA6, GCLC, ACE, ESR1, TNFSF4, LRP8
single-organism cellular process (GO:0044763)	0.65	11	ITGB3, GCLM, LTA, OLR1, F13A1, PSMA6, GCLC, ACE, ESR1, TNFSF4, LRP8
organic substance metabolic process (GO:0071704)	0.63	10	F7, GCLM, OLR1, F13A1, PSMA6, GCLC, ACE, ESR1, TNFSF4, LRP8
response to stimulus (GO:0050896)	1.22	10	ITGB3, GCLM, LTA, OLR1, F13A1, F7, GCLC, ESR1, TNFSF4, LRP8
regulation of biological process (GO:0050789)	0.45	10	ITGB3, GCLM, LTA, F7, PSMA6, GCLC, ACE, ESR1, TNFSF4, LRP8
metabolic process (GO:0008152)	0.58	10	F7, GCLM, OLR1, F13A1, PSMA6, GCLC, ACE, ESR1, TNFSF4, LRP8
regulation of cellular process (GO:0050794)	0.5	10	ITGB3, GCLM, LTA, F7, PSMA6, GCLC, ACE, ESR1, TNFSF4, LRP8
positive regulation of biological process (GO:0048518)	1.2	9	ITGB3, TNFSF4, LTA, F7, PSMA6, GCLC, ACE, ESR1, LRP8
negative regulation of biological process (GO:0048519)	1.33	9	ITGB3, GCLM, LTA, PSMA6, GCLC, ACE, ESR1, TNFSF4, LRP8
multicellular organismal process (GO:0032501)	1.45	9	ITGB3, GCLM, OLR1, F13A1, F7, GCLC, ESR1, TNFSF4, ACE
negative regulation of cellular process (GO:0048523)	1.41	9	ITGB3, GCLM, LTA, PSMA6, GCLC, ACE, ESR1, TNFSF4, LRP8
positive regulation of cellular process (GO:0048522)	1.3	9	ITGB3, TNFSF4, LTA, F7, PSMA6, GCLC, ACE, ESR1, LRP8
primary metabolic process (GO:0044238)	0.69	8	F7, TNFSF4, OLR1, F13A1, PSMA6, ACE, ESR1, LRP8
regulation of response to stimulus (GO:0048583)	1.54	8	ITGB3, GCLM, LTA, F7, PSMA6, GCLC, ESR1, TNFSF4
cellular metabolic process (GO:0044237)	0.69	8	F7, GCLM, F13A1, PSMA6, GCLC, ACE, ESR1, LRP8
regulation of multicellular organismal process (GO:0051239)	1.87	8	ITGB3, TNFSF4, LTA, F7, PSMA6, ACE, ESR1, LRP8
response to chemical (GO:0042221)	1.98	8	F7, GCLM, LTA, OLR1, GCLC, ESR1, TNFSF4, LRP8
regulation of biological quality (GO:0065008)	1.68	8	ITGB3, GCLM, F13A1, F7, PSMA6, GCLC, ESR1, ACE
positive regulation of metabolic process (GO:0009893)	1.74	7	ITGB3, TNFSF4, PSMA6, GCLC, ACE, ESR1, LRP8
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	7	ITGB3, TNFSF4, PSMA6, GCLC, ACE, ESR1, LRP8
regulation of metabolic process (GO:0019222)	1.02	7	ITGB3, TNFSF4, PSMA6, GCLC, ACE, ESR1, LRP8
regulation of macromolecule metabolic process (GO:0060255)	1.08	7	ITGB3, TNFSF4, PSMA6, GCLC, ACE, ESR1, LRP8
positive regulation of cellular metabolic process (GO:0031325)	1.81	7	ITGB3, TNFSF4, PSMA6, GCLC, ACE, ESR1, LRP8
regulation of cellular metabolic process (GO:0031323)	1.07	7	ITGB3, TNFSF4, PSMA6, GCLC, ACE, ESR1, LRP8
macromolecule metabolic process (GO:0043170)	0.83	7	F7, OLR1, F13A1, PSMA6, ACE, ESR1, LRP8
response to stress (GO:0006950)	1.8	7	ITGB3, TNFSF4, LTA, OLR1, F13A1, GCLC, GCLM
regulation of signaling (GO:0023051)	1.72	7	ITGB3, GCLM, F7, PSMA6, GCLC, ESR1, LRP8
regulation of molecular function (GO:0065009)	1.78	7	ITGB3, GCLM, PSMA6, ACE, ESR1, TNFSF4, LRP8
regulation of cell communication (GO:0010646)	1.73	7	ITGB3, GCLM, F7, PSMA6, GCLC, ESR1, LRP8
localization (GO:0051179)	1.4	7	ITGB3, OLR1, F13A1, F7, ACE, ESR1, LRP8
regulation of primary metabolic process (GO:0080090)	1.08	7	ITGB3, TNFSF4, PSMA6, GCLC, ACE, ESR1, LRP8
negative regulation of metabolic process (GO:0009892)	1.93	6	ITGB3, ESR1, PSMA6, GCLC, TNFSF4, LRP8
positive regulation of response to stimulus (GO:0048584)	2.18	6	ITGB3, ESR1, LTA, F7, PSMA6, TNFSF4
negative regulation of cellular metabolic process (GO:0031324)	2.01	6	ITGB3, ESR1, PSMA6, GCLC, TNFSF4, LRP8
signal transduction (GO:0007165)	1.28	6	ITGB3, ESR1, LTA, PSMA6, TNFSF4, LRP8
positive regulation of catalytic activity (GO:0043085)	2.4	6	ITGB3, GCLM, PSMA6, ACE, ESR1, LRP8
single-organism metabolic process (GO:0044710)	1.63	6	GCLM, PSMA6, GCLC, ACE, TNFSF4, LRP8
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	6	ITGB3, ESR1, PSMA6, GCLC, TNFSF4, LRP8
regulation of signal transduction (GO:0009966)	1.84	6	ITGB3, GCLM, F7, PSMA6, GCLC, ESR1
regulation of protein metabolic process (GO:0051246)	1.93	6	ITGB3, PSMA6, GCLC, ACE, ESR1, LRP8
positive regulation of protein metabolic process (GO:0051247)	2.43	6	ITGB3, PSMA6, GCLC, ACE, ESR1, LRP8
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	6	ITGB3, PSMA6, GCLC, ACE, ESR1, LRP8
positive regulation of molecular function (GO:0044093)	2.23	6	ITGB3, GCLM, PSMA6, ACE, ESR1, LRP8
regulation of protein modification process (GO:0031399)	2.32	6	ITGB3, PSMA6, GCLC, ACE, ESR1, LRP8
developmental process (GO:0032502)	1.36	6	ITGB3, LTA, F7, ACE, ESR1, LRP8
transport (GO:0006810)	1.51	6	ITGB3, OLR1, F13A1, F7, ACE, LRP8
regulation of developmental process (GO:0050793)	2.1	6	ESR1, LTA, PSMA6, ACE, TNFSF4, LRP8
regulation of catalytic activity (GO:0050790)	1.97	6	ITGB3, GCLM, PSMA6, ACE, ESR1, LRP8
regulation of biosynthetic process (GO:0009889)	1.37	6	ITGB3, ESR1, PSMA6, GCLC, TNFSF4, LRP8
single-organism developmental process (GO:0044767)	1.49	6	ITGB3, LTA, F7, ACE, ESR1, LRP8
establishment of localization (GO:0051234)	1.48	6	ITGB3, OLR1, F13A1, F7, ACE, LRP8
response to organic substance (GO:0010033)	2.2	6	F7, ESR1, LTA, GCLC, TNFSF4, LRP8
response to oxygen-containing compound (GO:1901700)	2.57	6	F7, ESR1, LTA, OLR1, TNFSF4, LRP8
regulation of cellular protein metabolic process (GO:0032268)	1.99	6	ITGB3, PSMA6, GCLC, ACE, ESR1, LRP8
single-multicellular organism process (GO:0044707)	1.78	6	ITGB3, ESR1, F13A1, F7, TNFSF4, ACE
protein metabolic process (GO:0019538)	1.45	6	F7, OLR1, F13A1, PSMA6, ACE, LRP8
anatomical structure development (GO:0048856)	1.58	6	ITGB3, LTA, F7, ACE, ESR1, LRP8
immune system process (GO:0002376)	2.29	6	ITGB3, LTA, OLR1, PSMA6, TNFSF4, ACE
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	6	ITGB3, ESR1, PSMA6, GCLC, TNFSF4, LRP8
regulation of multicellular organismal development (GO:2000026)	2.31	6	ESR1, LTA, PSMA6, ACE, TNFSF4, LRP8
positive regulation of protein modification process (GO:0031401)	2.7	5	ACE, ITGB3, ESR1, LRP8, PSMA6
negative regulation of biosynthetic process (GO:0009890)	2.47	5	GCLC, ITGB3, ESR1, TNFSF4, LRP8
regulation of cellular biosynthetic process (GO:0031326)	1.38	5	PSMA6, TNFSF4, GCLC, ESR1, LRP8
negative regulation of response to stimulus (GO:0048585)	2.52	5	PSMA6, GCLC, ESR1, TNFSF4, GCLM
cellular nitrogen compound metabolic process (GO:0034641)	1.22	5	ACE, F7, ESR1, GCLC, GCLM
nitrogen compound metabolic process (GO:0006807)	1.13	5	ACE, F7, ESR1, GCLC, GCLM
cell surface receptor signaling pathway (GO:0007166)	2.09	5	PSMA6, TNFSF4, ITGB3, LTA, LRP8
positive regulation of multicellular organismal process (GO:0051240)	2.49	5	LTA, TNFSF4, ITGB3, F7, LRP8
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	5	PSMA6, GCLC, ESR1, TNFSF4, LRP8
regulation of immune system process (GO:0002682)	2.5	5	PSMA6, ACE, F7, TNFSF4, LTA
proteolysis (GO:0006508)	2.73	5	ACE, OLR1, PSMA6, LRP8, F7
regulation of gene expression (GO:0010468)	1.37	5	PSMA6, GCLC, ESR1, TNFSF4, LRP8
regulation of cell proliferation (GO:0042127)	2.41	5	TNFSF4, ACE, ITGB3, ESR1, LTA
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	5	PSMA6, TNFSF4, GCLC, ESR1, LRP8
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	5	PSMA6, TNFSF4, GCLC, ESR1, LRP8
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	5	PSMA6, GCLC, ESR1, TNFSF4, LRP8
regulation of RNA biosynthetic process (GO:2001141)	1.55	5	PSMA6, TNFSF4, GCLC, ESR1, LRP8
regulation of localization (GO:0032879)	1.94	5	ACE, ITGB3, TNFSF4, ESR1, F7
vesicle-mediated transport (GO:0016192)	2.72	5	ITGB3, F13A1, OLR1, LRP8, F7
regulation of RNA metabolic process (GO:0051252)	1.52	5	PSMA6, TNFSF4, GCLC, ESR1, LRP8
regulation of transcription, DNA-templated (GO:0006355)	1.56	5	PSMA6, GCLC, ESR1, TNFSF4, LRP8
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	5	LRP8, GCLC, ESR1, ITGB3, TNFSF4
regulation of phosphate metabolic process (GO:0019220)	2.35	4	ITGB3, ESR1, ACE, LRP8
cytokine-mediated signaling pathway (GO:0019221)	3.6	4	LRP8, TNFSF4, PSMA6, LTA
regulation of response to external stimulus (GO:0032101)	3.06	4	TNFSF4, F7, PSMA6, LTA
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	4	TNFSF4, GCLC, ESR1, LRP8
positive regulation of signaling (GO:0023056)	2.41	4	ITGB3, PSMA6, ESR1, F7
negative regulation of signaling (GO:0023057)	2.65	4	GCLC, ESR1, PSMA6, GCLM
negative regulation of gene expression (GO:0010629)	2.48	4	GCLC, ESR1, TNFSF4, LRP8
circulatory system process (GO:0003013)	4.38	4	GCLC, OLR1, ACE, GCLM
negative regulation of cell communication (GO:0010648)	2.66	4	GCLC, ESR1, PSMA6, GCLM
positive regulation of cell communication (GO:0010647)	2.41	4	ITGB3, ESR1, F7, PSMA6
regulation of cell death (GO:0010941)	2.43	4	GCLC, ESR1, GCLM, LTA
regulation of apoptotic process (GO:0042981)	2.5	4	GCLC, ESR1, GCLM, LTA
cellular component organization or biogenesis (GO:0071840)	1.22	4	ITGB3, ESR1, GCLC, GCLM
positive regulation of transferase activity (GO:0051347)	3.31	4	ACE, ITGB3, PSMA6, LRP8
cellular macromolecule metabolic process (GO:0044260)	0.93	4	F7, F13A1, ESR1, PSMA6
positive regulation of signal transduction (GO:0009967)	2.5	4	ITGB3, PSMA6, ESR1, F7
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	4	ITGB3, ESR1, ACE, LRP8
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	4	GCLC, ESR1, TNFSF4, LRP8
cellular component organization (GO:0016043)	1.24	4	ITGB3, ESR1, GCLC, GCLM
regulation of programmed cell death (GO:0043067)	2.49	4	GCLC, ESR1, GCLM, LTA
animal organ development (GO:0048513)	2.53	4	ACE, F7, ESR1, LTA
positive regulation of cell proliferation (GO:0008284)	3.01	4	ITGB3, ESR1, LTA, TNFSF4
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	4	GCLC, ESR1, TNFSF4, LRP8
positive regulation of phosphate metabolic process (GO:0045937)	2.78	4	ITGB3, ESR1, ACE, LRP8
negative regulation of nucleic acid-templated transcription (GO:1903507)	2.71	4	GCLC, ESR1, TNFSF4, LRP8
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	4	GCLC, ESR1, TNFSF4, LRP8
regulation of cell differentiation (GO:0045595)	2.42	4	TNFSF4, ITGB3, LTA, LRP8
negative regulation of transcription, DNA-templated (GO:0045892)	2.75	4	GCLC, ESR1, TNFSF4, LRP8
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	4	GCLC, ESR1, TNFSF4, LRP8
system process (GO:0003008)	2.3	4	GCLC, OLR1, ACE, GCLM
regulation of phosphorylation (GO:0042325)	2.5	4	ITGB3, ESR1, ACE, LRP8
regulation of phosphorus metabolic process (GO:0051174)	2.35	4	ITGB3, ESR1, ACE, LRP8
positive regulation of phosphorylation (GO:0042327)	2.9	4	ITGB3, ESR1, ACE, LRP8
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090)	3.83	4	PSMA6, TNFSF4, ESR1, LRP8
organonitrogen compound metabolic process (GO:1901564)	2.32	4	GCLC, ACE, GCLM, F7
negative regulation of signal transduction (GO:0009968)	2.75	4	GCLC, ESR1, PSMA6, GCLM
cellular amide metabolic process (GO:0043603)	3.23	4	GCLC, ACE, GCLM, F7
positive regulation of immune system process (GO:0002684)	2.96	4	PSMA6, F7, TNFSF4, LTA
regulation of response to stress (GO:0080134)	2.53	4	TNFSF4, F7, PSMA6, LTA
regulation of transferase activity (GO:0051338)	2.88	4	ACE, ITGB3, PSMA6, LRP8
positive regulation of protein phosphorylation (GO:0001934)	2.95	4	ITGB3, ESR1, ACE, LRP8
response to lipid (GO:0033993)	3.11	4	LRP8, ESR1, TNFSF4, LTA
peptide metabolic process (GO:0006518)	3.44	4	GCLC, ACE, GCLM, F7
regulation of protein phosphorylation (GO:0001932)	2.57	4	ITGB3, ESR1, ACE, LRP8
negative regulation of RNA metabolic process (GO:0051253)	2.66	4	GCLC, ESR1, TNFSF4, LRP8
regulation of kinase activity (GO:0043549)	3.07	3	ITGB3, ACE, LRP8
hemostasis (GO:0007599)	4.5	3	ITGB3, F13A1, F7
positive regulation of response to external stimulus (GO:0032103)	4.17	3	F7, TNFSF4, LTA
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	3	ESR1, PSMA6, LRP8
regulation of transport (GO:0051049)	2.24	3	ITGB3, ESR1, TNFSF4
blood coagulation (GO:0007596)	4.52	3	ITGB3, F13A1, F7
regulation of homeostatic process (GO:0032844)	3.65	3	ITGB3, GCLC, GCLM
positive regulation of defense response (GO:0031349)	3.83	3	TNFSF4, PSMA6, LTA
vascular process in circulatory system (GO:0003018)	4.65	3	GCLC, ACE, GCLM
regulation of neuron apoptotic process (GO:0043523)	4.47	3	GCLC, ESR1, GCLM
small molecule metabolic process (GO:0044281)	2.38	3	GCLC, TNFSF4, GCLM
cellular response to chemical stimulus (GO:0070887)	2.57	3	TNFSF4, ESR1, LRP8
tumor necrosis factor-mediated signaling pathway (GO:0033209)	4.96	3	TNFSF4, PSMA6, LTA
single organismal cell-cell adhesion (GO:0016337)	3.69	3	ITGB3, OLR1, TNFSF4
regulation of anatomical structure size (GO:0090066)	3.78	3	GCLC, ACE, GCLM
response to organic cyclic compound (GO:0014070)	3.07	3	F7, ESR1, LRP8
response to endogenous stimulus (GO:0009719)	2.79	3	F7, GCLC, TNFSF4
cellular protein metabolic process (GO:0044267)	1.63	3	F7, F13A1, PSMA6
cellular response to stimulus (GO:0051716)	1.97	3	ESR1, TNFSF4, LRP8
regulation of blood vessel size (GO:0050880)	4.8	3	GCLC, ACE, GCLM
negative regulation of transport (GO:0051051)	3.6	3	ITGB3, TNFSF4, ESR1
cellular developmental process (GO:0048869)	1.82	3	ITGB3, ESR1, ACE
positive regulation of kinase activity (GO:0033674)	3.54	3	ITGB3, ACE, LRP8
regulation of inflammatory response (GO:0050727)	4.03	3	TNFSF4, PSMA6, LTA
regulation of cellular component movement (GO:0051270)	3.08	3	ITGB3, F7, ACE
cellular response to organic substance (GO:0071310)	2.78	3	ESR1, TNFSF4, LRP8
regulation of defense response (GO:0031347)	3.11	3	TNFSF4, PSMA6, LTA
negative regulation of molecular function (GO:0044092)	2.74	3	ESR1, PSMA6, TNFSF4
regulation of cell migration (GO:0030334)	3.23	3	ITGB3, F7, ACE
biological adhesion (GO:0022610)	2.81	3	ITGB3, OLR1, TNFSF4
regulation of tube size (GO:0035150)	4.79	3	GCLC, ACE, GCLM
single organism cell adhesion (GO:0098602)	3.63	3	ITGB3, OLR1, TNFSF4
regulation of immune response (GO:0050776)	2.98	3	TNFSF4, PSMA6, LTA
regulation of body fluid levels (GO:0050878)	3.76	3	ITGB3, F13A1, F7
cell proliferation (GO:0008283)	3.23	3	ESR1, ACE, TNFSF4
cell-cell adhesion (GO:0098609)	3.34	3	ITGB3, OLR1, TNFSF4
negative regulation of cell death (GO:0060548)	2.95	3	GCLC, ESR1, GCLM
positive regulation of protein kinase activity (GO:0045860)	3.61	3	ITGB3, ACE, LRP8
regulation of protein kinase activity (GO:0045859)	3.15	3	ITGB3, ACE, LRP8
cellular response to lipid (GO:0071396)	3.96	3	ESR1, TNFSF4, LRP8
negative regulation of protein metabolic process (GO:0051248)	2.82	3	ITGB3, GCLC, PSMA6
cellular protein modification process (GO:0006464)	1.79	3	F7, F13A1, PSMA6
response to hormone (GO:0009725)	3.33	3	GCLC, F7, TNFSF4
defense response (GO:0006952)	2.78	3	OLR1, TNFSF4, LTA
single-organism transport (GO:0044765)	2.18	3	ITGB3, F13A1, ACE
coagulation (GO:0050817)	4.51	3	ITGB3, F13A1, F7
cell adhesion (GO:0007155)	2.82	3	ITGB3, OLR1, TNFSF4
secretion (GO:0046903)	3.38	3	ITGB3, F13A1, ACE
regulation of neuron death (GO:1901214)	4.19	3	GCLC, ESR1, GCLM
negative regulation of neuron death (GO:1901215)	4.57	3	GCLC, ESR1, GCLM
response to oxidative stress (GO:0006979)	3.9	3	GCLC, OLR1, GCLM
single-organism localization (GO:1902578)	2.09	3	ITGB3, F13A1, ACE
multi-organism process (GO:0051704)	2.65	3	ITGB3, TNFSF4, LTA
positive regulation of cell differentiation (GO:0045597)	3.01	3	TNFSF4, LTA, LRP8
cellular response to oxygen-containing compound (GO:1901701)	3.22	3	TNFSF4, ESR1, LRP8
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091)	4.29	3	ESR1, PSMA6, LRP8
regulation of locomotion (GO:0040012)	3.12	3	ITGB3, F7, ACE
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	3	GCLC, ESR1, GCLM
response to external stimulus (GO:0009605)	2.55	3	F7, TNFSF4, LTA
cellular biosynthetic process (GO:0044249)	1.37	3	GCLC, ESR1, GCLM
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731)	4.62	3	ITGB3, ACE, LRP8
regulation of peptidyl-tyrosine phosphorylation (GO:0050730)	4.35	3	ITGB3, ACE, LRP8
biosynthetic process (GO:0009058)	1.32	3	GCLC, ESR1, GCLM
positive regulation of developmental process (GO:0051094)	2.77	3	TNFSF4, LRP8, LTA
response to drug (GO:0042493)	3.71	3	LRP8, GCLM, LTA
macromolecule modification (GO:0043412)	1.73	3	F7, F13A1, PSMA6
protein modification process (GO:0036211)	1.79	3	F7, F13A1, PSMA6
regulation of cell motility (GO:2000145)	3.16	3	ITGB3, F7, ACE
positive regulation of immune response (GO:0050778)	3.4	3	TNFSF4, PSMA6, LTA
organic substance biosynthetic process (GO:1901576)	1.34	3	GCLC, ESR1, GCLM
negative regulation of apoptotic signaling pathway (GO:2001234)	4.42	2	GCLC, GCLM
regulation of extrinsic apoptotic signaling pathway (GO:2001236)	4.69	2	GCLC, GCLM
negative regulation of extrinsic apoptotic signaling pathway (GO:2001237)	5.13	2	GCLC, GCLM
regulation of apoptotic signaling pathway (GO:2001233)	3.83	2	GCLC, GCLM
regulation of lymphocyte mediated immunity (GO:0002706)	4.99	2	TNFSF4, LTA
positive regulation of leukocyte mediated immunity (GO:0002705)	5.32	2	TNFSF4, LTA
regulation of leukocyte mediated immunity (GO:0002703)	4.7	2	TNFSF4, LTA
mitochondrion organization (GO:0007005)	3.69	2	GCLC, GCLM
positive regulation of lymphocyte mediated immunity (GO:0002708)	5.49	2	TNFSF4, LTA
hormone metabolic process (GO:0042445)	4.64	2	ESR1, ACE
positive regulation of inflammatory response (GO:0050729)	4.98	2	TNFSF4, LTA
response to external biotic stimulus (GO:0043207)	3.13	2	TNFSF4, LTA
regulation of hemopoiesis (GO:1903706)	4.0	2	TNFSF4, ACE
peptide biosynthetic process (GO:0043043)	3.73	2	GCLC, GCLM
response to wounding (GO:0009611)	4.39	2	ITGB3, F13A1
interspecies interaction between organisms (GO:0044419)	3.08	2	ITGB3, TNFSF4
rhythmic process (GO:0048511)	4.02	2	F7, ESR1
nonribosomal peptide biosynthetic process (GO:0019184)	6.84	2	GCLC, GCLM
positive regulation of cell development (GO:0010720)	3.57	2	LTA, LRP8
positive regulation of interferon-gamma production (GO:0032729)	5.59	2	TNFSF4, LTA
cellular homeostasis (GO:0019725)	3.23	2	GCLC, ESR1
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002824)	5.48	2	TNFSF4, LTA
sulfur amino acid metabolic process (GO:0000096)	6.47	2	GCLC, GCLM
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002822)	4.99	2	TNFSF4, LTA
negative regulation of cellular protein metabolic process (GO:0032269)	2.88	2	GCLC, PSMA6
positive regulation of adaptive immune response (GO:0002821)	5.42	2	TNFSF4, LTA
regulation of proteolysis (GO:0030162)	3.2	2	GCLC, PSMA6
protein catabolic process (GO:0030163)	3.93	2	ACE, PSMA6
oxoacid metabolic process (GO:0043436)	3.12	2	GCLC, GCLM
response to inorganic substance (GO:0010035)	3.56	2	OLR1, TNFSF4
response to other organism (GO:0051707)	3.48	2	TNFSF4, LTA
negative regulation of sequence-specific DNA binding transcription factor activity (GO:0043433)	4.82	2	TNFSF4, ESR1
dicarboxylic acid metabolic process (GO:0043648)	5.3	2	GCLC, GCLM
single organism reproductive process (GO:0044702)	2.73	2	ESR1, ACE
response to biotic stimulus (GO:0009607)	3.09	2	TNFSF4, LTA
cellular modified amino acid metabolic process (GO:0006575)	4.69	2	GCLC, GCLM
organonitrogen compound biosynthetic process (GO:1901566)	2.85	2	GCLC, GCLM
cell motility (GO:0048870)	3.02	2	ITGB3, OLR1
response to nutrient levels (GO:0031667)	3.77	2	F7, LTA
negative regulation of neuron apoptotic process (GO:0043524)	4.82	2	GCLC, GCLM
positive regulation of catabolic process (GO:0009896)	3.94	2	GCLC, PSMA6
regulation of membrane potential (GO:0042391)	3.89	2	GCLC, GCLM
regulation of catabolic process (GO:0009894)	3.52	2	GCLC, PSMA6
cellular modified amino acid biosynthetic process (GO:0042398)	6.07	2	GCLC, GCLM
regulation of interferon-gamma production (GO:0032649)	5.21	2	TNFSF4, LTA
movement of cell or subcellular component (GO:0006928)	2.61	2	ITGB3, OLR1
mononuclear cell proliferation (GO:0032943)	5.32	2	TNFSF4, ACE
secretion by cell (GO:0032940)	3.59	2	ITGB3, F13A1
(GO:1905330)	4.56	2	ESR1, PSMA6
glutamine family amino acid metabolic process (GO:0009064)	5.52	2	GCLC, GCLM
antigen processing and presentation of peptide antigen (GO:0048002)	4.56	2	ACE, PSMA6
serine family amino acid metabolic process (GO:0009069)	6.02	2	GCLC, GCLM
organic substance catabolic process (GO:1901575)	2.45	2	ACE, PSMA6
exocytosis (GO:0006887)	4.11	2	ITGB3, F13A1
regulated exocytosis (GO:0045055)	4.44	2	ITGB3, F13A1
organic cyclic compound metabolic process (GO:1901360)	1.26	2	TNFSF4, ESR1
regulation of protein tyrosine kinase activity (GO:0061097)	5.59	2	ACE, LRP8
positive regulation of protein tyrosine kinase activity (GO:0061098)	6.07	2	ACE, LRP8
cell migration (GO:0016477)	3.12	2	ITGB3, OLR1
antigen processing and presentation (GO:0019882)	4.36	2	ACE, PSMA6
lipid metabolic process (GO:0006629)	2.68	2	TNFSF4, LRP8
wound healing (GO:0042060)	5.13	2	ITGB3, F13A1
regulation of immunoglobulin mediated immune response (GO:0002889)	6.04	2	TNFSF4, LTA
cell activation (GO:0001775)	3.47	2	ITGB3, TNFSF4
inflammatory response (GO:0006954)	3.64	2	OLR1, TNFSF4
immune response (GO:0006955)	2.86	2	TNFSF4, LTA
positive regulation of intracellular signal transduction (GO:1902533)	2.95	2	F7, ESR1
regulation of intracellular signal transduction (GO:1902531)	2.31	2	F7, ESR1
endocytosis (GO:0006897)	3.69	2	OLR1, LRP8
protein maturation (GO:0051604)	4.48	2	F7, ACE
sulfur compound biosynthetic process (GO:0044272)	4.5	2	GCLC, GCLM
negative regulation of protein modification process (GO:0031400)	3.4	2	GCLC, PSMA6
receptor-mediated endocytosis (GO:0006898)	4.31	2	OLR1, LRP8
positive regulation of nervous system development (GO:0051962)	3.64	2	LTA, LRP8
regulation of immune effector process (GO:0002697)	3.71	2	TNFSF4, LTA
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	2	ESR1, LRP8
positive regulation of cell motility (GO:2000147)	3.74	2	ITGB3, F7
posttranscriptional regulation of gene expression (GO:0010608)	3.64	2	ESR1, PSMA6
glutathione biosynthetic process (GO:0006750)	6.9	2	GCLC, GCLM
leukocyte cell-cell adhesion (GO:0007159)	4.26	2	OLR1, TNFSF4
positive regulation of immune effector process (GO:0002699)	4.69	2	TNFSF4, LTA
regulation of fibroblast proliferation (GO:0048145)	5.32	2	ESR1, LTA
cell differentiation (GO:0030154)	2.14	2	ITGB3, ACE
regulation of adaptive immune response (GO:0002819)	4.91	2	TNFSF4, LTA
regulation of cellular component organization (GO:0051128)	2.01	2	ACE, LRP8
cellular catabolic process (GO:0044248)	2.62	2	ACE, PSMA6
regulation of protein catabolic process (GO:0042176)	3.83	2	GCLC, PSMA6
regulation of nervous system development (GO:0051960)	3.1	2	LTA, LRP8
anatomical structure morphogenesis (GO:0009653)	2.53	2	ITGB3, ESR1
positive regulation of immunoglobulin mediated immune response (GO:0002891)	6.47	2	TNFSF4, LTA
regulation of neurogenesis (GO:0050767)	3.21	2	LRP8, LTA
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	3.12	2	ESR1, LRP8
regulation of cell development (GO:0060284)	3.01	2	LRP8, LTA
positive regulation of neurogenesis (GO:0050769)	3.77	2	LRP8, LTA
regulation of protein modification by small protein conjugation or removal (GO:1903320)	4.14	2	GCLC, PSMA6
negative regulation of protein modification by small protein conjugation or removal (GO:1903321)	4.8	2	GCLC, PSMA6
glutathione metabolic process (GO:0006749)	5.57	2	GCLC, GCLM
regulation of protein ubiquitination (GO:0031396)	4.22	2	GCLC, PSMA6
negative regulation of protein ubiquitination (GO:0031397)	4.87	2	GCLC, PSMA6
alpha-amino acid metabolic process (GO:1901605)	4.5	2	GCLC, GCLM
negative regulation of cell proliferation (GO:0008285)	3.26	2	ESR1, LTA
multicellular organismal reproductive process (GO:0048609)	3.35	2	ESR1, ACE
response to abiotic stimulus (GO:0009628)	2.8	2	GCLC, LTA
positive regulation of proteolysis involved in cellular protein catabolic process (GO:1903052)	4.6	2	GCLC, PSMA6
positive regulation of cellular catabolic process (GO:0031331)	4.15	2	GCLC, PSMA6
regulation of proteolysis involved in cellular protein catabolic process (GO:1903050)	4.32	2	GCLC, PSMA6
negative regulation of cell differentiation (GO:0045596)	3.33	2	ITGB3, TNFSF4
defense response to other organism (GO:0098542)	3.75	2	TNFSF4, LTA
locomotion (GO:0040011)	2.91	2	ITGB3, OLR1
protein processing (GO:0016485)	4.62	2	F7, ACE
amide biosynthetic process (GO:0043604)	3.6	2	GCLC, GCLM
apoptotic mitochondrial changes (GO:0008637)	5.7	2	GCLC, GCLM
regulation of epithelial cell proliferation (GO:0050678)	4.06	2	ITGB3, ESR1
positive regulation of epithelial cell proliferation (GO:0050679)	4.67	2	ITGB3, ESR1
organic acid metabolic process (GO:0006082)	3.01	2	GCLC, GCLM
cellular response to organic cyclic compound (GO:0071407)	3.93	2	ESR1, LRP8
regulation of membrane depolarization (GO:0003254)	6.04	2	GCLC, GCLM
cysteine metabolic process (GO:0006534)	7.53	2	GCLC, GCLM
regulation of cytokine production (GO:0001817)	3.4	2	TNFSF4, LTA
glutamate metabolic process (GO:0006536)	6.36	2	GCLC, GCLM
response to molecule of bacterial origin (GO:0002237)	3.99	2	TNFSF4, LTA
regulation of mitochondrial depolarization (GO:0051900)	6.84	2	GCLC, GCLM
positive regulation of proteolysis (GO:0045862)	3.86	2	GCLC, PSMA6
response to nitrogen compound (GO:1901698)	3.12	2	F7, TNFSF4
positive regulation of cytokine production (GO:0001819)	3.82	2	TNFSF4, LTA
response to extracellular stimulus (GO:0009991)	3.71	2	F7, LTA
regulation of cellular catabolic process (GO:0031329)	3.83	2	GCLC, PSMA6
carboxylic acid metabolic process (GO:0019752)	3.12	2	GCLC, GCLM
homeostatic process (GO:0042592)	2.61	2	GCLC, ESR1
leukocyte migration (GO:0050900)	4.19	2	ITGB3, OLR1
cell death (GO:0008219)	3.05	2	OLR1, LTA
response to lipopolysaccharide (GO:0032496)	4.03	2	TNFSF4, LTA
antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	5.19	2	ACE, PSMA6
growth (GO:0040007)	3.8	2	ITGB3, ESR1
positive regulation of protein catabolic process (GO:0045732)	4.18	2	GCLC, PSMA6
platelet degranulation (GO:0002576)	5.12	2	ITGB3, F13A1
leukocyte proliferation (GO:0070661)	5.25	2	TNFSF4, ACE
negative regulation of apoptotic process (GO:0043066)	3.04	2	GCLC, GCLM
negative regulation of programmed cell death (GO:0043069)	3.02	2	GCLC, GCLM
positive regulation of cellular protein catabolic process (GO:1903364)	4.52	2	GCLC, PSMA6
positive regulation of cell migration (GO:0030335)	3.77	2	ITGB3, F7
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	2	ESR1, TNFSF4
regulation of cellular protein catabolic process (GO:1903362)	4.23	2	GCLC, PSMA6
response to nutrient (GO:0007584)	4.49	2	F7, LTA
regulation of hormone levels (GO:0010817)	3.56	2	ESR1, ACE
reproductive process (GO:0022414)	2.55	2	ESR1, ACE
regulation of B cell mediated immunity (GO:0002712)	6.02	2	TNFSF4, LTA
multi-organism cellular process (GO:0044764)	3.14	2	ITGB3, TNFSF4
positive regulation of B cell mediated immunity (GO:0002714)	6.47	2	TNFSF4, LTA
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	2	TNFSF4, ESR1
response to estrogen (GO:0043627)	5.25	2	F7, ESR1
response to nitrosative stress (GO:0051409)	7.94	2	GCLC, GCLM
catabolic process (GO:0009056)	2.38	2	ACE, PSMA6
macromolecule catabolic process (GO:0009057)	3.0	2	ACE, PSMA6
cellular localization (GO:0051641)	2.32	2	F7, ESR1
organelle organization (GO:0006996)	2.02	2	GCLC, GCLM
positive regulation of cellular component movement (GO:0051272)	3.71	2	ITGB3, F7
regulation of mitochondrial membrane potential (GO:0051881)	5.72	2	GCLC, GCLM
positive regulation of locomotion (GO:0040017)	3.71	2	ITGB3, F7
response to ketone (GO:1901654)	4.53	2	F7, TNFSF4
regulation of ion homeostasis (GO:2000021)	4.44	2	GCLC, GCLM
sulfur compound metabolic process (GO:0006790)	3.87	2	GCLC, GCLM
regulation of organ morphogenesis (GO:2000027)	4.22	2	ESR1, PSMA6
viral process (GO:0016032)	3.15	2	ITGB3, TNFSF4
symbiosis, encompassing mutualism through parasitism (GO:0044403)	3.15	2	ITGB3, TNFSF4

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
single organismal cell-cell adhesion (GO:0016337)	-	3.69	0.001	ITGB3, LTA, OLR1, F13A1, LGALS2, ESR1, ACE
positive regulation of response to external stimulus (GO:0032103)	-	4.17	0.009	ITGB3, ESR1, LTA, F13A1, F7, TNFSF4
regulation of response to external stimulus (GO:0032101)	-	3.06	0.0	ITGB3, TNFSF4, LTA, F13A1, F7, PSMA6, LGALS2, ACE, ESR1, LRP8
blood coagulation (GO:0007596)	-	4.52	0.007	ITGB3, F13A1, OLR1, LRP8, F7
regulation of adaptive immune response (GO:0002819)	-	4.91	0.019	TNFSF4, LGALS2, ITGB3, ESR1, LTA
single organism cell adhesion (GO:0098602)	-	3.63	0.002	ITGB3, LTA, OLR1, F13A1, LGALS2, ESR1, ACE
response to nitrosative stress (GO:0051409)	-	7.94	0.013	GCLC, GCLM
hemostasis (GO:0007599)	-	4.5	0.007	ITGB3, F13A1, OLR1, LRP8, F7
response to lipopolysaccharide (GO:0032496)	-	4.03	0.0	TNFSF4, LTA, OLR1, F13A1, LGALS2, ESR1, ACE
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090)	-	3.83	0.047	PSMA6, TNFSF4, ESR1, LRP8
positive regulation of immunoglobulin mediated immune response (GO:0002891)	-	6.47	0.034	TNFSF4, LTA
response to external biotic stimulus (GO:0043207)	-	3.13	0.0	ITGB3, TNFSF4, LTA, OLR1, F13A1, LGALS2, PSMA6, GCLC, ESR1, ACE
response to lipid (GO:0033993)	-	3.11	0.041	ITGB3, TNFSF4, LTA, OLR1, F13A1, F7, LGALS2, ACE, ESR1, LRP8
positive regulation of multicellular organismal process (GO:0051240)	-	2.49	0.032	ITGB3, TNFSF4, LTA, F13A1, F7, ACE, ESR1, LRP8
negative regulation of multicellular organismal process (GO:0051241)	NEW	2.84	0.036	ITGB3, TNFSF4, LTA, F13A1, F7, PSMA6, ESR1
regulation of inflammatory response (GO:0050727)	-	4.03	0.013	ITGB3, ESR1, LTA, PSMA6, TNFSF4, ACE
regulation of locomotion (GO:0040012)	-	3.12	0.003	ITGB3, LTA, F13A1, F7, PSMA6, LGALS2, ACE, ESR1, LRP8
regulation of cell motility (GO:2000145)	-	3.16	0.001	ITGB3, LTA, F13A1, F7, PSMA6, LGALS2, ACE, ESR1, LRP8
regulation of biological quality (GO:0065008)	-	1.68	0.003	ITGB3, ESR1, OLR1, F13A1, F7, GCLC, ACE, GCLM, LRP8
regulation of response to wounding (GO:1903034)	NEW	4.74	0.0	ITGB3, TNFSF4, LTA, F13A1, F7, PSMA6, LGALS2, ESR1, ACE
multicellular organismal process (GO:0032501)	-	1.45	0.001	ITGB3, GCLM, OLR1, F13A1, F7, GCLC, ACE, ESR1, TNFSF4, LRP8
regulation of body fluid levels (GO:0050878)	-	3.76	0.021	ITGB3, F13A1, OLR1, LRP8, F7
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002822)	-	4.99	0.012	LTA, TNFSF4, LGALS2, ITGB3, ESR1
regulation of cell migration (GO:0030334)	-	3.23	0.001	ITGB3, LTA, F13A1, F7, PSMA6, LGALS2, ACE, ESR1, LRP8
coagulation (GO:0050817)	-	4.51	0.007	ITGB3, F13A1, OLR1, LRP8, F7
defense response to other organism (GO:0098542)	-	3.75	0.038	ITGB3, ESR1, LTA, PSMA6, GCLC, TNFSF4
response to acid chemical (GO:0001101)	NEW	4.05	0.005	ITGB3, TNFSF4, OLR1, PSMA6, ACE, ESR1, LRP8
inflammatory response (GO:0006954)	-	3.64	0.001	ITGB3, TNFSF4, LTA, OLR1, F7, LGALS2, ESR1, LRP8
response to chemical (GO:0042221)	-	1.98	0.02	ITGB3, GCLM, LTA, OLR1, F7, GCLC, ESR1, TNFSF4, LRP8
response to other organism (GO:0051707)	-	3.48	0.002	ITGB3, TNFSF4, LTA, OLR1, F13A1, PSMA6, GCLC, ESR1
response to oxidative stress (GO:0006979)	-	3.9	0.044	ITGB3, GCLM, OLR1, GCLC, ESR1, ACE
response to oxygen-containing compound (GO:1901700)	-	2.57	0.038	F7, ESR1, LTA, OLR1, TNFSF4, LRP8
regulation of cellular component movement (GO:0051270)	-	3.08	0.002	ITGB3, LTA, F13A1, F7, PSMA6, LGALS2, ACE, ESR1, LRP8
response to biotic stimulus (GO:0009607)	-	3.09	0.0	ITGB3, TNFSF4, LTA, OLR1, F13A1, LGALS2, PSMA6, GCLC, ESR1, ACE
single-multicellular organism process (GO:0044707)	-	1.78	0.001	ITGB3, GCLM, OLR1, F13A1, F7, GCLC, ACE, ESR1, TNFSF4, LRP8
cellular amide metabolic process (GO:0043603)	-	3.23	0.007	ACE, GCLC, ESR1, PSMA6, GCLM
response to hormone (GO:0009725)	-	3.33	0.012	ITGB3, TNFSF4, OLR1, F13A1, F7, PSMA6, GCLC, ESR1, ACE
regulation of response to stress (GO:0080134)	-	2.53	0.003	ITGB3, TNFSF4, LTA, F13A1, F7, PSMA6, LGALS2, ACE, ESR1, LRP8
cysteine metabolic process (GO:0006534)	-	7.53	0.01	GCLC, GCLM
response to molecule of bacterial origin (GO:0002237)	-	3.99	0.001	TNFSF4, LTA, OLR1, F13A1, LGALS2, ESR1, ACE
regulation of mitochondrial depolarization (GO:0051900)	-	6.84	0.044	GCLC, ESR1, GCLM
positive regulation of B cell mediated immunity (GO:0002714)	-	6.47	0.034	TNFSF4, LTA
peptide metabolic process (GO:0006518)	-	3.44	0.029	GCLC, ACE, GCLM

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	12	ITGB3, GCLM, LTA, OLR1, F13A1, F7, PSMA6, GCLC, ACE, ESR1, TNFSF4, LRP8
intracellular part (GO:0044424)	0.28	10	ITGB3, ESR1, OLR1, F13A1, F7, PSMA6, GCLC, ACE, GCLM, LRP8
membrane (GO:0016020)	0.68	9	ITGB3, TNFSF4, LTA, OLR1, F7, GCLC, ACE, ESR1, LRP8
cytoplasmic part (GO:0044444)	0.82	8	ITGB3, GCLM, F13A1, F7, PSMA6, GCLC, ESR1, ACE
extracellular region part (GO:0044421)	1.57	8	ITGB3, LTA, OLR1, F13A1, F7, PSMA6, TNFSF4, ACE
plasma membrane (GO:0005886)	1.39	8	ITGB3, TNFSF4, LTA, OLR1, F7, ACE, ESR1, LRP8
protein complex (GO:0043234)	1.51	7	ITGB3, GCLM, OLR1, PSMA6, GCLC, ESR1, LRP8
macromolecular complex (GO:0032991)	1.35	7	ITGB3, GCLM, OLR1, PSMA6, GCLC, ESR1, LRP8
integral component of membrane (GO:0016021)	1.14	7	ITGB3, TNFSF4, OLR1, GCLC, ACE, ESR1, LRP8
intracellular organelle part (GO:0044446)	0.81	7	ITGB3, OLR1, F13A1, F7, PSMA6, ESR1, LRP8
intrinsic component of membrane (GO:0031224)	1.13	7	ITGB3, TNFSF4, OLR1, GCLC, ACE, ESR1, LRP8
membrane part (GO:0044425)	0.95	7	ITGB3, TNFSF4, OLR1, GCLC, ACE, ESR1, LRP8
organelle (GO:0043226)	0.4	7	ITGB3, OLR1, F7, PSMA6, ACE, ESR1, LRP8
organelle part (GO:0044422)	0.79	7	ITGB3, OLR1, F13A1, F7, PSMA6, ESR1, LRP8
plasma membrane part (GO:0044459)	1.95	6	ITGB3, ESR1, OLR1, ACE, TNFSF4, LRP8
intracellular organelle (GO:0043229)	0.51	6	ITGB3, OLR1, PSMA6, ACE, ESR1, LRP8
extracellular region (GO:0005576)	2.18	6	F7, LTA, OLR1, F13A1, ACE, LRP8
membrane-bounded organelle (GO:0043227)	0.47	6	ITGB3, OLR1, F7, PSMA6, ESR1, ACE
vesicle (GO:0031982)	1.64	5	ITGB3, F7, ACE, PSMA6, OLR1
intracellular membrane-bounded organelle (GO:0043231)	0.6	5	ITGB3, ESR1, ACE, PSMA6, OLR1
cytoplasm (GO:0005737)	1.01	4	ESR1, F13A1, ACE, PSMA6
extracellular organelle (GO:0043230)	1.89	4	ACE, ITGB3, OLR1, PSMA6
extracellular exosome (GO:0070062)	1.89	4	ITGB3, ACE, PSMA6, OLR1
membrane-bounded vesicle (GO:0031988)	1.71	4	ITGB3, ACE, PSMA6, OLR1
extracellular vesicle (GO:1903561)	1.89	4	ITGB3, ACE, PSMA6, OLR1
extracellular space (GO:0005615)	2.63	4	ACE, F7, TNFSF4, LTA
receptor complex (GO:0043235)	4.01	3	ITGB3, OLR1, LRP8
cytosol (GO:0005829)	1.68	3	GCLC, PSMA6, GCLM
nucleoplasm (GO:0005654)	1.89	3	OLR1, ESR1, PSMA6
nuclear part (GO:0044428)	1.55	3	OLR1, ESR1, PSMA6
integral component of plasma membrane (GO:0005887)	2.57	3	ITGB3, OLR1, TNFSF4
cell projection (GO:0042995)	2.47	3	ITGB3, ESR1, LRP8
intrinsic component of plasma membrane (GO:0031226)	2.53	3	ITGB3, OLR1, TNFSF4
nucleus (GO:0005634)	1.07	3	ITGB3, ESR1, PSMA6
plasma membrane region (GO:0098590)	2.97	2	ITGB3, LRP8
cell projection part (GO:0044463)	2.97	2	ITGB3, ESR1
catalytic complex (GO:1902494)	2.9	2	GCLC, GCLM
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	2	PSMA6, LRP8
organelle lumen (GO:0043233)	3.05	2	F7, F13A1
glutamate-cysteine ligase complex (GO:0017109)	9.11	2	GCLC, GCLM
membrane region (GO:0098589)	3.95	2	OLR1, LRP8
membrane-enclosed lumen (GO:0031974)	3.05	2	F7, F13A1
cytoplasmic vesicle part (GO:0044433)	3.41	2	ITGB3, F13A1
intracellular organelle lumen (GO:0070013)	3.05	2	F7, F13A1
non-membrane-bounded organelle (GO:0043228)	1.76	2	PSMA6, LRP8
neuron projection (GO:0043005)	3.12	2	ESR1, LRP8
synapse part (GO:0044456)	3.42	2	ESR1, LRP8
membrane microdomain (GO:0098857)	4.17	2	OLR1, LRP8
cell surface (GO:0009986)	3.44	2	ITGB3, TNFSF4
neuron part (GO:0097458)	2.64	2	ESR1, LRP8
membrane raft (GO:0045121)	4.18	2	OLR1, LRP8

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
extracellular space (GO:0005615)	-	2.63	0.002	ITGB3, TNFSF4, LTA, OLR1, F13A1, F7, PSMA6, ACE, ESR1, LRP8
organelle lumen (GO:0043233)	-	3.05	0.028	ITGB3, OLR1, F13A1, F7, PSMA6, ESR1, ACE
glutamate-cysteine ligase complex (GO:0017109)	-	9.11	0.0	GCLC, GCLM
membrane-enclosed lumen (GO:0031974)	-	3.05	0.045	ITGB3, OLR1, F13A1, F7, PSMA6, ESR1, ACE
extracellular region (GO:0005576)	-	2.18	0.036	ITGB3, LTA, OLR1, F13A1, F7, PSMA6, ACE, ESR1, LRP8
extracellular region part (GO:0044421)	-	1.57	0.047	ITGB3, LTA, OLR1, F13A1, F7, PSMA6, TNFSF4, ACE