Disease table of MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1 OMIM ID: 157300

Gene-disease associations table

GeneAssociated with MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1 inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
EDNRAOMIMHGNC link4q31.222157300, 616367
TNFOMIMHGNC link6p21.333611162, 600807, 157300
ESR1OMIMHGNC link6q25.14608446, 157300, 615363, 114480

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
62ESR1, TNF
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
ESR1YES68UGT2B15, AR, PELP1, EGFR, FLT1, RET, AVP, NRF1, CDK4, SERPINE1, PGR, FOS, VEGFA, CHAT, RUNX2, ZFHX3, CYP19A1, SERPINB9, TYMS, DCT, CXCL12, PTMA, HTRA2, NR5A2, CD24, HSPB1, CYP1B1, CTNNB1, MMP13, BRCA1, CYP2C19, BLM, OXT, TAC3, CCNA2, ZEB1, CDKN1A, STAT5A, TERT, MDM2, PMAIP1, CYP1A1, RARA, TP53, JUN, CDH1, AMH, CRHBP, MYC, TFF1, E2F1, CRH, KDR, BTG2, BCL2, UGT1A4, TGFA, KRT19, F12, FOXP1, ESRRA, GREB1, CTSD, JUNB, ESR1, YWHAQ, CCND1, CDKN1B1ESR1
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC12TNF, ESR1
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
TNFYES21SP1, HMGB2, ETV4, NFAT5, SPI1, HSF1, HDAC11, RELA, JUN, IRF5, EGR1, CEBPB, HDAC3, NR4A1, ATF2, AR, LRRFIP1, CEBPD, E2F1, NFKB1, SIRT10
ESR1YES27MECP2, RUNX2, TWIST1, TFAP2C, PGR, HDAC9, NCOR1, SP1, NKX3-1, ARNT, ID4, HDAC7, MTA1, BRCA1, BARX2, XBP1, STAT5A, LEF1, KDM4B, HDAC1, BARD1, STAT5B, PIAS3, TP53, GATA3, NR2E3, ESR11ESR1
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
EDNRAESR1No4SRC, KAT5, COPS5, HDAC7
TNFESR1No10HNRNPD, POU2F1, TBK1, CAV1, HSPB1, TAB2, RBCK1, RNF31, YWHAQ, CHUK

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
EDNRAESR1No-16NOS3, EGFR, GNAL, GNA11, OXT, GNA15, GNA14, GNG2, GNB1, GNAQ, RHOA, SRC, PTGFR, AKT1, VEGFA, GNAS

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Proteoglycans in cancerhsa052055.022TNF, ESR1

NET-GE enrichment

Term New enriched termICP valueGenes
cGMP-PKG signaling pathway (hsa04022) NEW5.320.012TNF, EDNRA, ESR1
Neuroactive ligand-receptor interaction (hsa04080) NEW4.580.032TNF, EDNRA, ESR1
Chemokine signaling pathway (hsa04062) NEW5.190.014TNF, EDNRA, ESR1
cAMP signaling pathway (hsa04024) NEW5.050.026TNF, EDNRA, ESR1
Proteoglycans in cancer (hsa05205) -5.020.022TNF, EDNRA, ESR1
Rap1 signaling pathway (hsa04015) NEW4.970.036TNF, EDNRA, ESR1
Cell motilityNEW4.90.029TNF, EDNRA, ESR1
Cytokine-cytokine receptor interaction (hsa04060) NEW4.670.049TNF, EDNRA, ESR1
Regulation of actin cytoskeleton (hsa04810) NEW4.90.029TNF, EDNRA, ESR1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signal TransductionR-HSA-1625821.783TNF, EDNRA, ESR1

NET-GE enrichment

Term New enriched termICP valueGenes
Regulation of gene expression in beta cells (R-HSA-210745) NEW8.660.012TNF, ESR1
Regulation of beta-cell development (R-HSA-186712) NEW7.980.046TNF, ESR1
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076) NEW4.690.023TNF, EDNRA, ESR1
Peptide ligand-binding receptors (R-HSA-375276) NEW5.410.005TNF, EDNRA, ESR1
Incretin synthesis, secretion, and inactivation (R-HSA-400508) NEW8.460.016TNF, ESR1
Nuclear signaling by ERBB4 (R-HSA-1251985) NEW7.70.037TNF, ESR1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.183TNF, EDNRA, ESR1
protein binding (GO:0005515) 0.463TNF, EDNRA, ESR1
transcription regulatory region DNA binding (GO:0044212) 3.032TNF, ESR1
signaling receptor activity (GO:0038023) 2.492EDNRA, ESR1
nucleic acid binding (GO:0003676) 1.442TNF, ESR1
organic cyclic compound binding (GO:0097159) 1.052TNF, ESR1
regulatory region DNA binding (GO:0000975) 3.032TNF, ESR1
regulatory region nucleic acid binding (GO:0001067) 3.032TNF, ESR1
enzyme binding (GO:0019899) 2.272TNF, ESR1
molecular transducer activity (GO:0060089) 2.322EDNRA, ESR1
receptor activity (GO:0004872) 2.322EDNRA, ESR1
signal transducer activity (GO:0004871) 2.282EDNRA, ESR1
DNA binding (GO:0003677) 1.922TNF, ESR1
receptor binding (GO:0005102) 2.432TNF, ESR1
heterocyclic compound binding (GO:1901363) 1.062TNF, ESR1
identical protein binding (GO:0042802) 2.632TNF, ESR1

NET-GE enrichment

Term New enriched termICP valueGenes
G-protein coupled peptide receptor activity (GO:0008528) NEW4.860.001TNF, EDNRA, ESR1
cytokine activity (GO:0005125) NEW4.340.014TNF, EDNRA, ESR1
growth factor activity (GO:0008083) NEW4.660.007TNF, EDNRA, ESR1
amide binding (GO:0033218) NEW4.140.017TNF, EDNRA, ESR1
receptor activator activity (GO:0030546) NEW6.270.021TNF, ESR1
peptide receptor activity (GO:0001653) NEW4.840.001TNF, EDNRA, ESR1
peptide binding (GO:0042277) NEW4.220.017TNF, EDNRA, ESR1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of phosphate metabolic process (GO:0019220) 2.353TNF, EDNRA, ESR1
regulation of primary metabolic process (GO:0080090) 1.083TNF, EDNRA, ESR1
regulation of metabolic process (GO:0019222) 1.023TNF, EDNRA, ESR1
regulation of transport (GO:0051049) 2.243TNF, EDNRA, ESR1
positive regulation of response to stimulus (GO:0048584) 2.183TNF, EDNRA, ESR1
regulation of response to stimulus (GO:0048583) 1.543TNF, EDNRA, ESR1
signal transduction (GO:0007165) 1.283TNF, EDNRA, ESR1
cellular response to stimulus (GO:0051716) 1.973TNF, EDNRA, ESR1
positive regulation of macromolecule metabolic process (GO:0010604) 1.813TNF, EDNRA, ESR1
regulation of signal transduction (GO:0009966) 1.843TNF, EDNRA, ESR1
positive regulation of signal transduction (GO:0009967) 2.53TNF, EDNRA, ESR1
animal organ development (GO:0048513) 2.533TNF, EDNRA, ESR1
positive regulation of molecular function (GO:0044093) 2.233TNF, EDNRA, ESR1
positive regulation of biological process (GO:0048518) 1.23TNF, EDNRA, ESR1
negative regulation of biological process (GO:0048519) 1.333TNF, EDNRA, ESR1
regulation of cell proliferation (GO:0042127) 2.413TNF, EDNRA, ESR1
regulation of macromolecule metabolic process (GO:0060255) 1.083TNF, EDNRA, ESR1
negative regulation of cell death (GO:0060548) 2.953TNF, EDNRA, ESR1
response to organic substance (GO:0010033) 2.23TNF, EDNRA, ESR1
regulation of phosphorylation (GO:0042325) 2.53TNF, EDNRA, ESR1
positive regulation of phosphorylation (GO:0042327) 2.93TNF, EDNRA, ESR1
single-multicellular organism process (GO:0044707) 1.783TNF, EDNRA, ESR1
negative regulation of metabolic process (GO:0009892) 1.933TNF, EDNRA, ESR1
positive regulation of metabolic process (GO:0009893) 1.743TNF, EDNRA, ESR1
negative regulation of biosynthetic process (GO:0009890) 2.473TNF, EDNRA, ESR1
positive regulation of biosynthetic process (GO:0009891) 2.293TNF, EDNRA, ESR1
regulation of apoptotic process (GO:0042981) 2.53TNF, EDNRA, ESR1
regulation of biological process (GO:0050789) 0.453TNF, EDNRA, ESR1
regulation of cell communication (GO:0010646) 1.733TNF, EDNRA, ESR1
positive regulation of hydrolase activity (GO:0051345) 2.913TNF, EDNRA, ESR1
biological regulation (GO:0065007) 0.393TNF, EDNRA, ESR1
single-organism process (GO:0044699) 0.483TNF, EDNRA, ESR1
regulation of molecular function (GO:0065009) 1.783TNF, EDNRA, ESR1
regulation of biological quality (GO:0065008) 1.683TNF, EDNRA, ESR1
positive regulation of catalytic activity (GO:0043085) 2.43TNF, EDNRA, ESR1
regulation of developmental process (GO:0050793) 2.13TNF, EDNRA, ESR1
regulation of catalytic activity (GO:0050790) 1.973TNF, EDNRA, ESR1
regulation of biosynthetic process (GO:0009889) 1.373TNF, EDNRA, ESR1
regulation of cellular process (GO:0050794) 0.53TNF, EDNRA, ESR1
positive regulation of MAPK cascade (GO:0043410) 3.573TNF, EDNRA, ESR1
regulation of multicellular organismal process (GO:0051239) 1.873TNF, EDNRA, ESR1
positive regulation of intracellular signal transduction (GO:1902533) 2.953TNF, EDNRA, ESR1
regulation of intracellular signal transduction (GO:1902531) 2.313TNF, EDNRA, ESR1
regulation of hydrolase activity (GO:0051336) 2.533TNF, EDNRA, ESR1
single-organism developmental process (GO:0044767) 1.493TNF, EDNRA, ESR1
response to stimulus (GO:0050896) 1.223TNF, EDNRA, ESR1
positive regulation of protein modification process (GO:0031401) 2.73TNF, EDNRA, ESR1
cellular developmental process (GO:0048869) 1.823TNF, EDNRA, ESR1
positive regulation of signaling (GO:0023056) 2.413TNF, EDNRA, ESR1
regulation of signaling (GO:0023051) 1.723TNF, EDNRA, ESR1
positive regulation of cell communication (GO:0010647) 2.413TNF, EDNRA, ESR1
anatomical structure morphogenesis (GO:0009653) 2.533TNF, EDNRA, ESR1
response to organic cyclic compound (GO:0014070) 3.073TNF, EDNRA, ESR1
regulation of MAPK cascade (GO:0043408) 3.223TNF, EDNRA, ESR1
positive regulation of phosphorus metabolic process (GO:0010562) 2.783TNF, EDNRA, ESR1
regulation of anatomical structure morphogenesis (GO:0022603) 2.793TNF, EDNRA, ESR1
regulation of protein metabolic process (GO:0051246) 1.933TNF, EDNRA, ESR1
positive regulation of protein metabolic process (GO:0051247) 2.433TNF, EDNRA, ESR1
positive regulation of cellular protein metabolic process (GO:0032270) 2.493TNF, EDNRA, ESR1
regulation of protein modification process (GO:0031399) 2.323TNF, EDNRA, ESR1
positive regulation of cell proliferation (GO:0008284) 3.013TNF, EDNRA, ESR1
multicellular organismal process (GO:0032501) 1.453TNF, EDNRA, ESR1
cell proliferation (GO:0008283) 3.233TNF, EDNRA, ESR1
cellular process (GO:0009987) 0.263TNF, EDNRA, ESR1
regulation of localization (GO:0032879) 1.943TNF, EDNRA, ESR1
regulation of cellular protein metabolic process (GO:0032268) 1.993TNF, EDNRA, ESR1
positive regulation of ERK1 and ERK2 cascade (GO:0070374) 4.563TNF, EDNRA, ESR1
regulation of ERK1 and ERK2 cascade (GO:0070372) 4.233TNF, EDNRA, ESR1
developmental process (GO:0032502) 1.363TNF, EDNRA, ESR1
positive regulation of cellular biosynthetic process (GO:0031328) 2.33TNF, EDNRA, ESR1
negative regulation of cellular biosynthetic process (GO:0031327) 2.493TNF, EDNRA, ESR1
regulation of cellular biosynthetic process (GO:0031326) 1.383TNF, EDNRA, ESR1
positive regulation of cellular metabolic process (GO:0031325) 1.813TNF, EDNRA, ESR1
negative regulation of cellular metabolic process (GO:0031324) 2.013TNF, EDNRA, ESR1
regulation of cellular metabolic process (GO:0031323) 1.073TNF, EDNRA, ESR1
regulation of cell death (GO:0010941) 2.433TNF, EDNRA, ESR1
response to lipid (GO:0033993) 3.113TNF, EDNRA, ESR1
regulation of programmed cell death (GO:0043067) 2.493TNF, EDNRA, ESR1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.353TNF, EDNRA, ESR1
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.553TNF, EDNRA, ESR1
positive regulation of phosphate metabolic process (GO:0045937) 2.783TNF, EDNRA, ESR1
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433TNF, EDNRA, ESR1
regulation of phosphorus metabolic process (GO:0051174) 2.353TNF, EDNRA, ESR1
single-organism cellular process (GO:0044763) 0.653TNF, EDNRA, ESR1
regulation of nitrogen compound metabolic process (GO:0051171) 1.363TNF, EDNRA, ESR1
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.473TNF, EDNRA, ESR1
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.293TNF, EDNRA, ESR1
response to chemical (GO:0042221) 1.983TNF, EDNRA, ESR1
localization (GO:0051179) 1.43TNF, EDNRA, ESR1
response to oxygen-containing compound (GO:1901700) 2.573TNF, EDNRA, ESR1
anatomical structure development (GO:0048856) 1.583TNF, EDNRA, ESR1
regulation of multicellular organismal development (GO:2000026) 2.313TNF, EDNRA, ESR1
regulation of organ morphogenesis (GO:2000027) 4.223TNF, EDNRA, ESR1
regulation of protein phosphorylation (GO:0001932) 2.573TNF, EDNRA, ESR1
positive regulation of protein phosphorylation (GO:0001934) 2.953TNF, EDNRA, ESR1
negative regulation of cellular process (GO:0048523) 1.413TNF, EDNRA, ESR1
positive regulation of cellular process (GO:0048522) 1.33TNF, EDNRA, ESR1
protein localization (GO:0008104) 2.362TNF, ESR1
positive regulation of monooxygenase activity (GO:0032770) 6.472TNF, ESR1
negative regulation of response to stimulus (GO:0048585) 2.522TNF, ESR1
cell development (GO:0048468) 3.282EDNRA, ESR1
positive regulation of homeostatic process (GO:0032846) 4.382TNF, EDNRA
regulation of homeostatic process (GO:0032844) 3.652TNF, EDNRA
positive regulation of defense response (GO:0031349) 3.832TNF, EDNRA
calcium ion homeostasis (GO:0055074) 3.972EDNRA, ESR1
inorganic ion homeostasis (GO:0098771) 3.432EDNRA, ESR1
regulation of defense response (GO:0031347) 3.112TNF, EDNRA
positive regulation of inflammatory response (GO:0050729) 4.982TNF, EDNRA
negative regulation of macromolecule metabolic process (GO:0010605) 2.012TNF, ESR1
response to external biotic stimulus (GO:0043207) 3.132TNF, EDNRA
cellular macromolecule localization (GO:0070727) 3.12TNF, ESR1
posttranscriptional regulation of gene expression (GO:0010608) 3.642TNF, ESR1
regulation of inflammatory response (GO:0050727) 4.032TNF, EDNRA
negative regulation of lipid metabolic process (GO:0045833) 5.332TNF, ESR1
morphogenesis of a branching epithelium (GO:0061138) 4.772EDNRA, ESR1
negative regulation of molecular function (GO:0044092) 2.742TNF, ESR1
macromolecule localization (GO:0033036) 2.342TNF, ESR1
positive regulation of reactive oxygen species biosynthetic process (GO:1903428) 5.862TNF, ESR1
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122) 4.272TNF, ESR1
cellular homeostasis (GO:0019725) 3.232EDNRA, ESR1
negative regulation of transport (GO:0051051) 3.62TNF, ESR1
positive regulation of transport (GO:0051050) 2.92TNF, EDNRA
regulation of phospholipase C activity (GO:1900274) 6.072EDNRA, ESR1
regulation of RNA biosynthetic process (GO:2001141) 1.552TNF, ESR1
response to abiotic stimulus (GO:0009628) 2.82TNF, EDNRA
single organism reproductive process (GO:0044702) 2.732EDNRA, ESR1
response to biotic stimulus (GO:0009607) 3.092TNF, EDNRA
response to external stimulus (GO:0009605) 2.552TNF, EDNRA
response to organonitrogen compound (GO:0010243) 3.22TNF, EDNRA
positive regulation of cytosolic calcium ion concentration (GO:0007204) 4.562EDNRA, ESR1
chemical homeostasis (GO:0048878) 2.972EDNRA, ESR1
negative regulation of gene expression (GO:0010629) 2.482TNF, ESR1
morphogenesis of a branching structure (GO:0001763) 4.712EDNRA, ESR1
negative regulation of glucose import (GO:0046325) 7.092TNF, ESR1
(GO:1905330) 4.562TNF, ESR1
positive regulation of phospholipase C activity (GO:0010863) 6.152EDNRA, ESR1
positive regulation of oxidoreductase activity (GO:0051353) 5.942TNF, ESR1
organic substance biosynthetic process (GO:1901576) 1.342TNF, ESR1
regulation of oxidoreductase activity (GO:0051341) 5.272TNF, ESR1
regulation of smooth muscle cell proliferation (GO:0048660) 5.12TNF, ESR1
cellular macromolecule metabolic process (GO:0044260) 0.932TNF, ESR1
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242TNF, ESR1
negative regulation of phosphate metabolic process (GO:0045936) 3.452TNF, EDNRA
cellular component organization (GO:0016043) 1.242TNF, ESR1
positive regulation of leukocyte migration (GO:0002687) 5.052TNF, EDNRA
positive regulation of immune system process (GO:0002684) 2.962TNF, EDNRA
regulation of leukocyte migration (GO:0002685) 4.722TNF, EDNRA
regulation of immune system process (GO:0002682) 2.52TNF, EDNRA
cellular component organization or biogenesis (GO:0071840) 1.222TNF, ESR1
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.812TNF, ESR1
positive regulation of translation (GO:0045727) 5.142TNF, ESR1
G-protein coupled receptor signaling pathway (GO:0007186) 2.642EDNRA, ESR1
positive regulation of reactive oxygen species metabolic process (GO:2000379) 5.292TNF, ESR1
regulation of monooxygenase activity (GO:0032768) 5.692TNF, ESR1
transport (GO:0006810) 1.512TNF, EDNRA
regulation of reactive oxygen species metabolic process (GO:2000377) 4.712TNF, ESR1
response to stress (GO:0006950) 1.82TNF, EDNRA
metabolic process (GO:0008152) 0.582TNF, ESR1
establishment of localization (GO:0051234) 1.482TNF, EDNRA
primary metabolic process (GO:0044238) 0.692TNF, ESR1
negative regulation of signal transduction (GO:0009968) 2.752TNF, ESR1
regulation of response to stress (GO:0080134) 2.532TNF, EDNRA
regulation of transcription, DNA-templated (GO:0006355) 1.562TNF, ESR1
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392TNF, ESR1
regulation of macromolecule biosynthetic process (GO:0010556) 1.432TNF, ESR1
regulation of cell motility (GO:2000145) 3.162TNF, EDNRA
positive regulation of cell motility (GO:2000147) 3.742TNF, EDNRA
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532TNF, ESR1
positive regulation of cellular amide metabolic process (GO:0034250) 5.02TNF, ESR1
positive regulation of lipase activity (GO:0060193) 5.542EDNRA, ESR1
regulation of lipase activity (GO:0060191) 5.312EDNRA, ESR1
positive regulation of response to external stimulus (GO:0032103) 4.172TNF, EDNRA
regulation of response to external stimulus (GO:0032101) 3.062TNF, EDNRA
ion homeostasis (GO:0050801) 3.422EDNRA, ESR1
negative regulation of signaling (GO:0023057) 2.652TNF, ESR1
positive regulation of nitric oxide biosynthetic process (GO:0045429) 5.992TNF, ESR1
regulation of nitric oxide biosynthetic process (GO:0045428) 5.762TNF, ESR1
negative regulation of cell communication (GO:0010648) 2.662TNF, ESR1
cellular response to chemical stimulus (GO:0070887) 2.572TNF, ESR1
response to endogenous stimulus (GO:0009719) 2.792TNF, EDNRA
divalent inorganic cation homeostasis (GO:0072507) 3.92EDNRA, ESR1
cellular divalent inorganic cation homeostasis (GO:0072503) 3.962EDNRA, ESR1
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122TNF, ESR1
positive regulation of multicellular organismal process (GO:0051240) 2.492TNF, EDNRA
negative regulation of phosphorus metabolic process (GO:0010563) 3.452TNF, EDNRA
regulation of morphogenesis of a branching structure (GO:0060688) 5.762TNF, ESR1
positive regulation of nitric oxide metabolic process (GO:1904407) 5.992TNF, ESR1
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562TNF, ESR1
macromolecule metabolic process (GO:0043170) 0.832TNF, ESR1
tube morphogenesis (GO:0035239) 4.352EDNRA, ESR1
multicellular organismal reproductive process (GO:0048609) 3.352EDNRA, ESR1
cellular response to oxygen-containing compound (GO:1901701) 3.222TNF, ESR1
cellular metal ion homeostasis (GO:0006875) 3.752EDNRA, ESR1
cellular calcium ion homeostasis (GO:0006874) 4.012EDNRA, ESR1
cellular response to lipid (GO:0071396) 3.962TNF, ESR1
cellular ion homeostasis (GO:0006873) 3.572EDNRA, ESR1
regulation of cellular amide metabolic process (GO:0034248) 3.882TNF, ESR1
regulation of cellular component movement (GO:0051270) 3.082TNF, EDNRA
negative regulation of transcription, DNA-templated (GO:0045892) 2.752TNF, ESR1
positive regulation of transcription, DNA-templated (GO:0045893) 2.562TNF, ESR1
cellular cation homeostasis (GO:0030003) 3.62EDNRA, ESR1
cation homeostasis (GO:0055080) 3.462EDNRA, ESR1
response to alkaloid (GO:0043279) 4.832TNF, EDNRA
cellular chemical homeostasis (GO:0055082) 3.42EDNRA, ESR1
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091) 4.292TNF, ESR1
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) 3.832TNF, ESR1
regulation of epithelial cell proliferation (GO:0050678) 4.062EDNRA, ESR1
positive regulation of developmental process (GO:0051094) 2.772TNF, EDNRA
cellular response to organic cyclic compound (GO:0071407) 3.932TNF, ESR1
negative regulation of RNA metabolic process (GO:0051253) 2.662TNF, ESR1
regulation of RNA metabolic process (GO:0051252) 1.522TNF, ESR1
positive regulation of RNA metabolic process (GO:0051254) 2.512TNF, ESR1
epithelial cell proliferation (GO:0050673) 5.212TNF, ESR1
positive regulation of RNA biosynthetic process (GO:1902680) 2.542TNF, ESR1
positive regulation of gene expression (GO:0010628) 2.352TNF, ESR1
response to molecule of bacterial origin (GO:0002237) 3.992TNF, EDNRA
response to nitrogen compound (GO:1901698) 3.122TNF, EDNRA
regulation of glucose import (GO:0046324) 5.632TNF, ESR1
regulation of cellular localization (GO:0060341) 3.032TNF, EDNRA
macromolecular complex subunit organization (GO:0043933) 2.142TNF, ESR1
branching morphogenesis of an epithelial tube (GO:0048754) 4.932EDNRA, ESR1
homeostatic process (GO:0042592) 2.612EDNRA, ESR1
regulation of glucose transport (GO:0010827) 5.122TNF, ESR1
negative regulation of glucose transport (GO:0010829) 6.92TNF, ESR1
intracellular signal transduction (GO:0035556) 2.392TNF, EDNRA
morphogenesis of an epithelium (GO:0002009) 4.082EDNRA, ESR1
regulation of gene expression (GO:0010468) 1.372TNF, ESR1
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462TNF, ESR1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62TNF, ESR1
multicellular organism development (GO:0007275) 2.542TNF, EDNRA
organic substance metabolic process (GO:0071704) 0.632TNF, ESR1
cellular response to organic substance (GO:0071310) 2.782TNF, ESR1
negative regulation of apoptotic process (GO:0043066) 3.042TNF, EDNRA
tissue morphogenesis (GO:0048729) 3.872EDNRA, ESR1
organic substance transport (GO:0071702) 2.152TNF, EDNRA
negative regulation of programmed cell death (GO:0043069) 3.022TNF, EDNRA
regulation of reactive oxygen species biosynthetic process (GO:1903426) 5.552TNF, ESR1
positive regulation of cell migration (GO:0030335) 3.772TNF, EDNRA
regulation of cell migration (GO:0030334) 3.232TNF, EDNRA
response to lipopolysaccharide (GO:0032496) 4.032TNF, EDNRA
regulation of lipid metabolic process (GO:0019216) 4.082TNF, ESR1
cellular protein localization (GO:0034613) 3.112TNF, ESR1
regulation of hormone levels (GO:0010817) 3.562TNF, ESR1
negative regulation of RNA biosynthetic process (GO:1902679) 2.72TNF, ESR1
reproductive process (GO:0022414) 2.552EDNRA, ESR1
biosynthetic process (GO:0009058) 1.322TNF, ESR1
macromolecule biosynthetic process (GO:0009059) 1.612TNF, ESR1
regulation of nucleic acid-templated transcription (GO:1903506) 1.552TNF, ESR1
metal ion homeostasis (GO:0055065) 3.612EDNRA, ESR1
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712TNF, ESR1
single-organism localization (GO:1902578) 2.092TNF, EDNRA
cellular localization (GO:0051641) 2.322TNF, ESR1
positive regulation of cellular component movement (GO:0051272) 3.712TNF, EDNRA
regulation of locomotion (GO:0040012) 3.122TNF, EDNRA
positive regulation of locomotion (GO:0040017) 3.712TNF, EDNRA
regulation of cytosolic calcium ion concentration (GO:0051480) 4.412EDNRA, ESR1
cellular metabolic process (GO:0044237) 0.692TNF, ESR1
positive regulation of phospholipase activity (GO:0010518) 5.762EDNRA, ESR1
regulation of translation (GO:0006417) 3.962TNF, ESR1
regulation of phospholipase activity (GO:0010517) 5.572EDNRA, ESR1

NET-GE enrichment

Term New enriched termICP valueGenes
positive regulation of histone acetylation (GO:0035066) NEW6.330.04TNF, ESR1
positive regulation of lipase activity (GO:0060193) -5.540.005TNF, EDNRA, ESR1
positive regulation of homeostatic process (GO:0032846) -4.380.008TNF, EDNRA, ESR1
regulation of lymphocyte mediated immunity (GO:0002706) NEW4.990.022TNF, EDNRA, ESR1
circulatory system process (GO:0003013) NEW4.380.03TNF, EDNRA, ESR1
regulation of leukocyte mediated immunity (GO:0002703) NEW4.70.042TNF, EDNRA, ESR1
positive regulation of chemotaxis (GO:0050921) NEW4.940.013TNF, EDNRA, ESR1
positive regulation of inflammatory response (GO:0050729) -4.980.045TNF, EDNRA
negative regulation of homotypic cell-cell adhesion (GO:0034111) NEW7.020.01TNF, ESR1
MAPK cascade (GO:0000165) NEW3.910.046TNF, EDNRA, ESR1
positive regulation of steroid biosynthetic process (GO:0010893) NEW7.160.023TNF, ESR1
positive regulation of lipid metabolic process (GO:0045834) NEW4.880.01TNF, EDNRA, ESR1
regulation of thymocyte apoptotic process (GO:0070243) NEW7.240.024TNF, ESR1
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002822) NEW4.990.028TNF, EDNRA, ESR1
response to calcium ion (GO:0051592) NEW4.980.01TNF, EDNRA, ESR1
regulation of development, heterochronic (GO:0040034) NEW7.240.02TNF, ESR1
regulation of phospholipase C activity (GO:1900274) -6.070.033EDNRA, ESR1
response to monosaccharide (GO:0034284) NEW4.770.025TNF, EDNRA, ESR1
positive regulation of cytosolic calcium ion concentration (GO:0007204) -4.560.017TNF, EDNRA, ESR1
positive regulation of oxidoreductase activity (GO:0051353) -5.940.01TNF, ESR1
positive regulation of cell division (GO:0051781) NEW5.350.006TNF, EDNRA, ESR1
regulation of chemotaxis (GO:0050920) NEW4.530.036TNF, EDNRA, ESR1
ovulation cycle process (GO:0022602) NEW5.250.006TNF, EDNRA, ESR1
regulation of kidney development (GO:0090183) NEW5.720.002TNF, EDNRA, ESR1
positive regulation of neutrophil migration (GO:1902624) NEW6.430.038TNF, EDNRA
positive regulation of phospholipase C activity (GO:0010863) -6.150.031EDNRA, ESR1
regulation of oxidoreductase activity (GO:0051341) -5.270.042TNF, ESR1
positive regulation of leukocyte migration (GO:0002687) -5.050.006TNF, EDNRA, ESR1
regulation of leukocyte migration (GO:0002685) -4.720.021TNF, EDNRA, ESR1
regulation of leukocyte chemotaxis (GO:0002688) NEW5.170.004TNF, EDNRA, ESR1
regulation of monooxygenase activity (GO:0032768) -5.690.017TNF, ESR1
regulation of symbiosis, encompassing mutualism through parasitism (GO:0043903) NEW3.820.046TNF, EDNRA, ESR1
regulation of dephosphorylation (GO:0035303) NEW4.670.037TNF, EDNRA, ESR1
phosphatidylinositol-mediated signaling (GO:0048015) NEW4.930.012TNF, EDNRA, ESR1
regulation of cytokine biosynthetic process (GO:0042035) NEW5.150.015TNF, EDNRA, ESR1
negative regulation of neurological system process (GO:0031645) NEW7.020.02TNF, ESR1
response to increased oxygen levels (GO:0036296) NEW6.40.036TNF, ESR1
negative regulation of interleukin-5 production (GO:0032714) NEW7.780.002TNF, ESR1
positive regulation of leukocyte chemotaxis (GO:0002690) NEW5.350.002TNF, EDNRA, ESR1
positive regulation of immune effector process (GO:0002699) NEW4.690.041TNF, EDNRA, ESR1
positive regulation of monooxygenase activity (GO:0032770) -6.470.003TNF, ESR1
regulation of lipase activity (GO:0060191) -5.310.019TNF, EDNRA, ESR1
regulation of fibroblast proliferation (GO:0048145) NEW5.320.005TNF, EDNRA, ESR1
fibroblast proliferation (GO:0048144) NEW8.630.001EDNRA, ESR1
regulation of adaptive immune response (GO:0002819) NEW4.910.038TNF, EDNRA, ESR1
positive regulation of nitric oxide biosynthetic process (GO:0045429) -5.990.007TNF, ESR1
regulation of nitric oxide biosynthetic process (GO:0045428) -5.760.014TNF, ESR1
response to organic cyclic compound (GO:0014070) -3.070.048TNF, EDNRA, ESR1
ovulation from ovarian follicle (GO:0001542) NEW7.650.003TNF, ESR1
protein localization to cell surface (GO:0034394) NEW6.640.047TNF, ESR1
granulocyte differentiation (GO:0030851) NEW7.020.024TNF, ESR1
inositol lipid-mediated signaling (GO:0048017) NEW4.910.012TNF, EDNRA, ESR1
regulation of morphogenesis of a branching structure (GO:0060688) -5.760.019TNF, ESR1
positive regulation of response to wounding (GO:1903036) NEW5.760.013TNF, EDNRA, ESR1
cell proliferation (GO:0008283) -3.230.032TNF, EDNRA, ESR1
negative regulation of toll-like receptor signaling pathway (GO:0034122) NEW6.430.049TNF, ESR1
negative regulation of platelet aggregation (GO:0090331) NEW7.330.007TNF, ESR1
regulation of platelet aggregation (GO:0090330) NEW6.840.02TNF, ESR1
positive regulation of lipid biosynthetic process (GO:0046889) NEW5.550.001TNF, EDNRA, ESR1
mammary gland alveolus development (GO:0060749) NEW6.960.026TNF, ESR1
epithelial cell proliferation (GO:0050673) -5.210.038TNF, ESR1
positive regulation of ERK1 and ERK2 cascade (GO:0070374) -4.560.014TNF, EDNRA, ESR1
regulation of ERK1 and ERK2 cascade (GO:0070372) -4.230.047TNF, EDNRA, ESR1
activation of MAPK activity (GO:0000187) NEW4.790.025TNF, EDNRA, ESR1
positive regulation of peptidyl-serine phosphorylation (GO:0033138) NEW5.260.004TNF, EDNRA, ESR1
regulation of peptidyl-serine phosphorylation (GO:0033135) NEW4.980.009TNF, EDNRA, ESR1
branching morphogenesis of an epithelial tube (GO:0048754) -4.930.039TNF, EDNRA, ESR1
glucose homeostasis (GO:0042593) NEW4.60.041TNF, EDNRA, ESR1
regulation of blood pressure (GO:0008217) NEW4.720.024TNF, EDNRA, ESR1
regulation of lipid biosynthetic process (GO:0046890) NEW4.870.02TNF, EDNRA, ESR1
response to glucose (GO:0009749) NEW4.860.02TNF, EDNRA, ESR1
response to hyperoxia (GO:0055093) NEW6.40.036TNF, ESR1
positive regulation of neutrophil chemotaxis (GO:0090023) NEW6.590.038TNF, EDNRA
response to lipid (GO:0033993) -3.110.042TNF, EDNRA, ESR1
carbohydrate homeostasis (GO:0033500) NEW4.60.041TNF, EDNRA, ESR1
positive regulation of angiogenesis (GO:0045766) NEW4.930.024TNF, EDNRA, ESR1
lymph node development (GO:0048535) NEW6.90.049TNF, EDNRA
regulation of receptor activity (GO:0010469) NEW4.980.009TNF, EDNRA, ESR1
response to retinoic acid (GO:0032526) NEW5.020.033TNF, EDNRA, ESR1
adult locomotory behavior (GO:0008344) NEW5.30.017TNF, EDNRA, ESR1
response to hexose (GO:0009746) NEW4.820.023TNF, EDNRA, ESR1
response to carbohydrate (GO:0009743) NEW4.620.044TNF, EDNRA, ESR1
cytosolic calcium ion homeostasis (GO:0051480) -4.410.033TNF, EDNRA, ESR1
positive regulation of lipid catabolic process (GO:0050996) NEW6.510.049TNF, ESR1
positive regulation of phospholipase activity (GO:0010518) -5.760.045EDNRA, ESR1
regulation of ion homeostasis (GO:2000021) NEW4.440.039TNF, EDNRA, ESR1
positive regulation of osteoclast differentiation (GO:0045672) NEW6.550.04TNF, ESR1
regulation of organ morphogenesis (GO:2000027) -4.220.0TNF, EDNRA, ESR1
positive regulation of behavior (GO:0048520) NEW6.470.021TNF, EDNRA, ESR1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
integral component of membrane (GO:0016021) 1.143TNF, EDNRA, ESR1
membrane (GO:0016020) 0.683TNF, EDNRA, ESR1
cell part (GO:0044464) 0.113TNF, EDNRA, ESR1
cytoplasmic part (GO:0044444) 0.823TNF, EDNRA, ESR1
plasma membrane (GO:0005886) 1.393TNF, EDNRA, ESR1
intracellular part (GO:0044424) 0.283TNF, EDNRA, ESR1
membrane part (GO:0044425) 0.953TNF, EDNRA, ESR1
plasma membrane part (GO:0044459) 1.953TNF, EDNRA, ESR1
intrinsic component of membrane (GO:0031224) 1.133TNF, EDNRA, ESR1
membrane region (GO:0098589) 3.952TNF, EDNRA
intracellular membrane-bounded organelle (GO:0043231) 0.62TNF, ESR1
T-tubule (GO:0030315) 6.092EDNRA, ESR1
membrane-bounded organelle (GO:0043227) 0.472TNF, ESR1
membrane raft (GO:0045121) 4.182TNF, EDNRA
intracellular organelle part (GO:0044446) 0.812EDNRA, ESR1
intracellular organelle (GO:0043229) 0.512TNF, ESR1
nuclear part (GO:0044428) 1.552EDNRA, ESR1
integral component of plasma membrane (GO:0005887) 2.572TNF, EDNRA
membrane microdomain (GO:0098857) 4.172TNF, EDNRA
intrinsic component of plasma membrane (GO:0031226) 2.532TNF, EDNRA
organelle (GO:0043226) 0.42TNF, ESR1
organelle part (GO:0044422) 0.792EDNRA, ESR1

NET-GE enrichment

Term New enriched termICP valueGenes
rough endoplasmic reticulum (GO:0005791) NEW5.830.02TNF, ESR1
adherens junction (GO:0005912) NEW3.660.042TNF, EDNRA, ESR1
apical plasma membrane (GO:0016324) NEW4.130.021TNF, EDNRA, ESR1
anchoring junction (GO:0070161) NEW3.610.047TNF, EDNRA, ESR1
ciliary membrane (GO:0060170) NEW5.430.042TNF, EDNRA
cell cortex (GO:0005938) NEW4.780.001TNF, EDNRA, ESR1
basal plasma membrane (GO:0009925) NEW6.340.012TNF, ESR1
cell-substrate adherens junction (GO:0005924) NEW3.830.026TNF, EDNRA, ESR1
focal adhesion (GO:0005925) NEW3.830.024TNF, EDNRA, ESR1
cell-substrate junction (GO:0030055) NEW3.820.026TNF, EDNRA, ESR1