Disease table of LISSENCEPHALY OMIM ID: PS607432

Gene-disease associations table

GeneAssociated with LISSENCEPHALY inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
ARXClinVar, OMIM, HUMSAVARHGNC linkXp21.35PS607432, PS309510, 300004, PS308350, PS309530
TUBA1AClinVar, OMIM, HUMSAVARHGNC link12q13.121PS607432
KATNB1ClinVar, OMIM, HUMSAVARHGNC link16q211PS607432
RELNClinVar, OMIMHGNC link7q22.12PS600512, PS607432
APOC3ClinVar, OMIM, HUMSAVARHGNC link11q23.31PS607432
DCXClinVar, OMIM, HUMSAVARHGNC linkXq231PS607432
LAMB1ClinVar, OMIMHGNC link7q31.11PS607432
PAFAH1B1ClinVar, OMIM, HUMSAVARHGNC link17p13.31PS607432
CDK5ClinVar, OMIMHGNC link7q36.11PS607432

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
7q32LAMB1, CDK5
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
7q3RELN, LAMB1, CDK5
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
73RELN, LAMB1, CDK5
X2DCX, ARX
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
ARXYES1KDM5C0
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
RELNYES4HDAC1, DNMT1, TBR1, MECP20
APOC3YES10SP1, PPARGC1A, NR2F6, NR2F1, SMAD4, JUN, SMAD3, ATF2, PPARA, HNF4A0
LAMB1YES2SSB, NANOG0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
TUBA1AKATNB1No3SSX2IP, NDEL1, PAFAH1B1
TUBA1ARELNNo1SQSTM1
TUBA1ADCXNo2NTRK1, PAFAH1B1
TUBA1ALAMB1No4NTRK1, UBC, TMEM25, FBXO6
TUBA1APAFAH1B1Yes7NDEL1, PAFAH1B1, HSP90AA1, MAPRE1, IQCB1, CLIP1, NTRK1
TUBA1ACDK5No12CDKN1A, NDEL1, EGFR, MAPT, PARK2, TP53, HSP90AA1, HSP90AB1, NTRK1, UCHL1, TLN1, HTRA2
KATNB1DCXNo1PAFAH1B1
KATNB1PAFAH1B1Yes5DYNC1H1, KATNB1, NDEL1, KATNA1, PAFAH1B1
KATNB1CDK5No1NDEL1
DCXLAMB1No1NTRK1
DCXPAFAH1B1Yes3NTRK1, DCX, PAFAH1B1
DCXCDK5No2NTRK1, APP
LAMB1PAFAH1B1No1NTRK1
LAMB1CDK5No1NTRK1
PAFAH1B1CDK5No4NTRK1, NDEL1, HSP90AA1, CEP128

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
ARXTUBA1AYesbinding0
ARXPAFAH1B1No-1TUBA1A
ARXCDK5No-2MEF2C, MEF2A
TUBA1ARELNNo-1PAFAH1B1
TUBA1AAPOC3No-1PPARA
TUBA1ADCXNo-1PAFAH1B1
TUBA1ALAMB1No-1UBC
TUBA1APAFAH1B1Yesbinding79CEP76, TUBGCP5, CDK1, CDK5RAP2, CEP57, CSNK1E, SSNA1, ACTR1A, YWHAE, CEP152, FGFR1OP, CEP78, ALMS1, CSNK1D, TUBG2, PLK1, TUBG1, TUBA4A, TUBGCP6, PRKACA, TUBA1B, CEP135, CLASP2, SFI1, DCTN2, CEP250, DYNLL1, TUBGCP2, MAPRE1, TUBA1C, TUBB4A, DYNC1H1, OFD1, DYNC1I2, SDCCAG8, CLIP1, YWHAG, ARL6, CEP164, NEDD1, AJUBA, CEP63, DNAH17, CCP110, DCTN3, CKAP5, AZI1, PRKAR2B, MAPRE3, HSP90AA1, ODF2, CENPJ, NINL, KIF19, CEP70, PPP2R1A, DNAH11, BORA, TUBGCP3, CEP290, DNAH9, HAUS2, DYNC1I1, KIF18B, TUBB4B, AURKA, CLASP1, NEK2, CNTRL, TUBGCP4, CEP72, PCM1, DYNC2H1, CEP192, UBC, ARL3, PCNT, PLK4, NDE1
TUBA1ACDK5No-7CDK1, CDK5RAP2, HSP90AA1, CSNK1D, UBC, MYC, PPARA
RELNAPOC3No-3LRP8, APOE, FOXO1
RELNDCXNo-2MAPK8, PAFAH1B1
RELNLAMB1No-19ITGA9, ITGAV, ITGB8, ITGA6, ITGA8, ITGA5, ITGA3, ITGA11, ITGB6, PTK2, ITGA1, ITGA7, ITGA2B, ITGB5, ITGB1, ITGB7, ITGA4, ITGB4, ITGA2
RELNPAFAH1B1Yesactivation, binding6PAFAH1B2, MAP1B, VLDLR, DAB1, AURKB, PAFAH1B3
RELNCDK5No-4FYN, GRIN2B, GRIN2A, ABL1
APOC3LAMB1No-0
APOC3CDK5No-4LPL, INS, LPIN1, PPARA
DCXPAFAH1B1Yesbinding0
DCXCDK5Yesbinding, ptmod2JUN, CDH2
LAMB1PAFAH1B1No-3UBC, RAC1, CDC42
LAMB1CDK5No-4UBC, PXN, PAK1, RAC1
PAFAH1B1CDK5No-10RAC1, NDEL1, CDK5RAP2, CDK1, DCX, CSNK1D, HSP90AA1, UBC, CDC20, NCOR1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
ECM-receptor interactionhsa045126.092LAMB1, RELN
Focal adhesionhsa045104.922LAMB1, RELN
PI3K-Akt signaling pathwayhsa041514.212LAMB1, RELN

NET-GE enrichment

Term New enriched termICP valueGenes
Toxoplasmosis (hsa05145) NEW5.710.005LAMB1, TUBA1A, RELN, CDK5
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Axon guidanceR-HSA-4224753.934DCX, LAMB1, TUBA1A, CDK5
Signal TransductionR-HSA-1625821.784APOC3, TUBA1A, CDK5, PAFAH1B1
Developmental BiologyR-HSA-12667383.484DCX, LAMB1, TUBA1A, CDK5
L1CAM interactionsR-HSA-3737606.193LAMB1, TUBA1A, DCX
Separation of Sister ChromatidsR-HSA-24678135.552TUBA1A, PAFAH1B1
Signaling by Rho GTPasesR-HSA-1943154.432TUBA1A, PAFAH1B1
Loss of Nlp from mitotic centrosomesR-HSA-3802597.032TUBA1A, PAFAH1B1
Cell CycleR-HSA-16401703.892TUBA1A, PAFAH1B1
Assembly of the primary ciliumR-HSA-56178335.442TUBA1A, PAFAH1B1
Factors involved in megakaryocyte development and platelet productionR-HSA-9832315.882TUBA1A, CDK5
Recruitment of mitotic centrosome proteins and complexesR-HSA-3802706.682TUBA1A, PAFAH1B1
Resolution of Sister Chromatid CohesionR-HSA-25002576.182TUBA1A, PAFAH1B1
Mitotic Metaphase and AnaphaseR-HSA-25553965.452TUBA1A, PAFAH1B1
Organelle biogenesis and maintenanceR-HSA-18522414.632TUBA1A, PAFAH1B1
Cell Cycle, MitoticR-HSA-692784.162TUBA1A, PAFAH1B1
G2/M TransitionR-HSA-692756.062TUBA1A, PAFAH1B1
RHO GTPases Activate ForminsR-HSA-56632206.012TUBA1A, PAFAH1B1
Loss of proteins required for interphase microtubule organization from the centrosomeR-HSA-3802847.032TUBA1A, PAFAH1B1
Centrosome maturationR-HSA-3802876.682TUBA1A, PAFAH1B1
Mitotic G2-G2/M phasesR-HSA-4532746.042TUBA1A, PAFAH1B1
M PhaseR-HSA-688864.872TUBA1A, PAFAH1B1
Anchoring of the basal body to the plasma membraneR-HSA-56209126.512TUBA1A, PAFAH1B1
Mitotic AnaphaseR-HSA-688825.462TUBA1A, PAFAH1B1
RHO GTPase EffectorsR-HSA-1952584.942TUBA1A, PAFAH1B1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-25659426.662TUBA1A, PAFAH1B1
HemostasisR-HSA-1095823.982TUBA1A, CDK5
Mitotic PrometaphaseR-HSA-688776.082TUBA1A, PAFAH1B1

NET-GE enrichment

Term New enriched termICP valueGenes
Axon guidance (R-HSA-422475) -3.930.018DCX, LAMB1, TUBA1A, CDK5
RHO GTPases Activate Formins (R-HSA-5663220) -6.010.034TUBA1A, CDK5, PAFAH1B1
L1CAM interactions (R-HSA-373760) -6.190.004DCX, LAMB1, TUBA1A, PAFAH1B1, CDK5
DARPP-32 events (R-HSA-180024) NEW8.40.029CDK5, PAFAH1B1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.188PAFAH1B1, KATNB1, DCX, APOC3, TUBA1A, ARX, CDK5, RELN
protein binding (GO:0005515) 0.467PAFAH1B1, KATNB1, DCX, APOC3, TUBA1A, CDK5, RELN
catalytic activity (GO:0003824) 1.056PAFAH1B1, KATNB1, DCX, TUBA1A, CDK5, RELN
hydrolase activity (GO:0016787) 1.94TUBA1A, RELN, KATNB1, PAFAH1B1
organic cyclic compound binding (GO:0097159) 1.054APOC3, TUBA1A, CDK5, ARX
cytoskeletal protein binding (GO:0008092) 3.024DCX, KATNB1, CDK5, PAFAH1B1
tubulin binding (GO:0015631) 4.13KATNB1, DCX, PAFAH1B1
carbohydrate derivative binding (GO:0097367) 2.033TUBA1A, CDK5, PAFAH1B1
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.773CDK5, DCX, RELN
microtubule binding (GO:0008017) 4.423KATNB1, DCX, PAFAH1B1
kinase activity (GO:0016301) 2.933CDK5, DCX, RELN
enzyme binding (GO:0019899) 2.273CDK5, DCX, PAFAH1B1
small molecule binding (GO:0036094) 1.893APOC3, TUBA1A, CDK5
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.083CDK5, DCX, RELN
transferase activity (GO:0016740) 1.953CDK5, DCX, RELN
protein kinase activity (GO:0004672) 3.273CDK5, RELN, DCX
receptor binding (GO:0005102) 2.433APOC3, CDK5, RELN
heterocyclic compound binding (GO:1901363) 1.063TUBA1A, CDK5, ARX
purine ribonucleoside triphosphate binding (GO:0035639) 2.222TUBA1A, CDK5
macromolecular complex binding (GO:0044877) 2.612PAFAH1B1, ARX
nucleotide binding (GO:0000166) 1.962TUBA1A, CDK5
purine nucleoside binding (GO:0001883) 2.222TUBA1A, CDK5
nucleoside binding (GO:0001882) 2.212TUBA1A, CDK5
molecular function regulator (GO:0098772) 2.512APOC3, CDK5
dynein binding (GO:0045502) 6.442KATNB1, PAFAH1B1
structural molecule activity (GO:0005198) 3.12LAMB1, TUBA1A
protein serine/threonine kinase activity (GO:0004674) 3.642CDK5, DCX
nucleoside phosphate binding (GO:1901265) 1.962TUBA1A, CDK5
ribonucleoside binding (GO:0032549) 2.222TUBA1A, CDK5
purine nucleotide binding (GO:0017076) 2.192TUBA1A, CDK5
lipoprotein particle receptor binding (GO:0070325) 6.652APOC3, RELN
nucleoside-triphosphatase activity (GO:0017111) 3.092TUBA1A, KATNB1
protein kinase binding (GO:0019901) 3.442CDK5, DCX
kinase binding (GO:0019900) 3.322CDK5, DCX
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 3.032TUBA1A, KATNB1
hydrolase activity, acting on acid anhydrides (GO:0016817) 3.032TUBA1A, KATNB1
pyrophosphatase activity (GO:0016462) 3.042TUBA1A, KATNB1
purine ribonucleotide binding (GO:0032555) 2.22TUBA1A, CDK5
protein dimerization activity (GO:0046983) 2.722KATNB1, PAFAH1B1
purine ribonucleoside binding (GO:0032550) 2.222TUBA1A, CDK5
ribonucleotide binding (GO:0032553) 2.192TUBA1A, CDK5

NET-GE enrichment

Term New enriched termICP valueGenes
tubulin binding (GO:0015631) -4.10.026DCX, TUBA1A, KATNB1, PAFAH1B1, CDK5
lipoprotein particle receptor binding (GO:0070325) -6.650.004APOC3, RELN
microtubule binding (GO:0008017) -4.420.01DCX, TUBA1A, KATNB1, PAFAH1B1, CDK5
histone kinase activity (GO:0035173) NEW6.790.016TUBA1A, CDK5
protein complex binding (GO:0032403) NEW3.090.046DCX, LAMB1, KATNB1, PAFAH1B1
dynein binding (GO:0045502) -6.440.018KATNB1, PAFAH1B1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.269PAFAH1B1, KATNB1, DCX, APOC3, TUBA1A, ARX, CDK5, LAMB1, RELN
single-organism cellular process (GO:0044763) 0.659PAFAH1B1, KATNB1, DCX, APOC3, TUBA1A, ARX, CDK5, LAMB1, RELN
single-organism process (GO:0044699) 0.489PAFAH1B1, KATNB1, DCX, APOC3, TUBA1A, ARX, CDK5, LAMB1, RELN
biological regulation (GO:0065007) 0.398PAFAH1B1, KATNB1, DCX, APOC3, ARX, CDK5, LAMB1, RELN
regulation of biological process (GO:0050789) 0.458PAFAH1B1, KATNB1, DCX, APOC3, ARX, CDK5, LAMB1, RELN
regulation of cellular process (GO:0050794) 0.58PAFAH1B1, KATNB1, DCX, APOC3, ARX, CDK5, LAMB1, RELN
positive regulation of biological process (GO:0048518) 1.27PAFAH1B1, KATNB1, APOC3, ARX, CDK5, LAMB1, RELN
cellular component organization (GO:0016043) 1.247PAFAH1B1, KATNB1, DCX, APOC3, CDK5, LAMB1, RELN
cellular component organization or biogenesis (GO:0071840) 1.227PAFAH1B1, KATNB1, DCX, APOC3, CDK5, LAMB1, RELN
developmental process (GO:0032502) 1.366PAFAH1B1, LAMB1, DCX, ARX, CDK5, RELN
primary metabolic process (GO:0044238) 0.696PAFAH1B1, DCX, APOC3, ARX, CDK5, RELN
multicellular organismal process (GO:0032501) 1.456PAFAH1B1, DCX, APOC3, ARX, CDK5, RELN
metabolic process (GO:0008152) 0.586PAFAH1B1, DCX, APOC3, ARX, CDK5, RELN
single-multicellular organism process (GO:0044707) 1.786PAFAH1B1, DCX, APOC3, ARX, CDK5, RELN
cellular developmental process (GO:0048869) 1.826PAFAH1B1, LAMB1, DCX, ARX, CDK5, RELN
cell differentiation (GO:0030154) 2.146PAFAH1B1, LAMB1, DCX, ARX, CDK5, RELN
cellular metabolic process (GO:0044237) 0.696PAFAH1B1, DCX, APOC3, ARX, CDK5, RELN
movement of cell or subcellular component (GO:0006928) 2.616PAFAH1B1, KATNB1, DCX, ARX, CDK5, RELN
single-organism developmental process (GO:0044767) 1.496PAFAH1B1, LAMB1, DCX, ARX, CDK5, RELN
organic substance metabolic process (GO:0071704) 0.636PAFAH1B1, DCX, APOC3, ARX, CDK5, RELN
regulation of multicellular organismal process (GO:0051239) 1.876PAFAH1B1, KATNB1, APOC3, ARX, CDK5, RELN
localization (GO:0051179) 1.46PAFAH1B1, KATNB1, APOC3, TUBA1A, CDK5, RELN
positive regulation of cellular process (GO:0048522) 1.36PAFAH1B1, KATNB1, APOC3, CDK5, LAMB1, RELN
regulation of primary metabolic process (GO:0080090) 1.085APOC3, CDK5, RELN, PAFAH1B1, ARX
regulation of metabolic process (GO:0019222) 1.025APOC3, CDK5, RELN, PAFAH1B1, ARX
cell projection organization (GO:0030030) 3.145DCX, LAMB1, RELN, PAFAH1B1, CDK5
regulation of cellular metabolic process (GO:0031323) 1.075APOC3, CDK5, PAFAH1B1, RELN, ARX
regulation of cellular component organization (GO:0051128) 2.015APOC3, KATNB1, RELN, PAFAH1B1, CDK5
neuron migration (GO:0001764) 5.05DCX, CDK5, RELN, PAFAH1B1, ARX
anatomical structure morphogenesis (GO:0009653) 2.535DCX, LAMB1, RELN, PAFAH1B1, CDK5
cellular component morphogenesis (GO:0032989) 3.55DCX, LAMB1, RELN, PAFAH1B1, CDK5
negative regulation of biological process (GO:0048519) 1.335APOC3, KATNB1, PAFAH1B1, ARX, CDK5
macromolecule localization (GO:0033036) 2.345APOC3, KATNB1, PAFAH1B1, RELN, CDK5
regulation of developmental process (GO:0050793) 2.15KATNB1, RELN, PAFAH1B1, ARX, CDK5
transport (GO:0006810) 1.515APOC3, TUBA1A, KATNB1, PAFAH1B1, CDK5
establishment of localization (GO:0051234) 1.485APOC3, TUBA1A, KATNB1, PAFAH1B1, CDK5
single-organism localization (GO:1902578) 2.095APOC3, KATNB1, RELN, CDK5, PAFAH1B1
cellular localization (GO:0051641) 2.325TUBA1A, RELN, KATNB1, PAFAH1B1, CDK5
locomotion (GO:0040011) 2.915DCX, CDK5, RELN, PAFAH1B1, ARX
cell migration (GO:0016477) 3.125DCX, CDK5, RELN, PAFAH1B1, ARX
cell motility (GO:0048870) 3.025DCX, CDK5, RELN, PAFAH1B1, ARX
anatomical structure development (GO:0048856) 1.585DCX, CDK5, RELN, PAFAH1B1, ARX
macromolecule metabolic process (GO:0043170) 0.835APOC3, CDK5, RELN, DCX, ARX
system development (GO:0048731) 2.925DCX, CDK5, RELN, PAFAH1B1, ARX
negative regulation of cellular process (GO:0048523) 1.415APOC3, KATNB1, PAFAH1B1, ARX, CDK5
protein localization (GO:0008104) 2.364KATNB1, RELN, PAFAH1B1, CDK5
negative regulation of metabolic process (GO:0009892) 1.934APOC3, CDK5, PAFAH1B1, ARX
positive regulation of metabolic process (GO:0009893) 1.744APOC3, CDK5, RELN, ARX
regulation of cellular biosynthetic process (GO:0031326) 1.384APOC3, CDK5, RELN, ARX
negative regulation of cellular metabolic process (GO:0031324) 2.014APOC3, CDK5, PAFAH1B1, ARX
regulation of response to stimulus (GO:0048583) 1.544APOC3, CDK5, RELN, PAFAH1B1
negative regulation of cellular component organization (GO:0051129) 3.354APOC3, KATNB1, CDK5, PAFAH1B1
hippocampus development (GO:0021766) 5.64DCX, CDK5, RELN, PAFAH1B1
regulation of signaling (GO:0023051) 1.724APOC3, CDK5, RELN, PAFAH1B1
regulation of phosphate metabolic process (GO:0019220) 2.354APOC3, CDK5, RELN, PAFAH1B1
regulation of cell communication (GO:0010646) 1.734APOC3, CDK5, RELN, PAFAH1B1
regulation of cell projection organization (GO:0031344) 3.384KATNB1, RELN, PAFAH1B1, CDK5
cell division (GO:0051301) 3.684TUBA1A, KATNB1, PAFAH1B1, CDK5
regulation of neurogenesis (GO:0050767) 3.214KATNB1, RELN, CDK5, PAFAH1B1
regulation of localization (GO:0032879) 1.944APOC3, LAMB1, CDK5, RELN
cellular macromolecule metabolic process (GO:0044260) 0.934CDK5, RELN, DCX, ARX
regulation of signal transduction (GO:0009966) 1.844APOC3, CDK5, RELN, PAFAH1B1
positive regulation of multicellular organismal process (GO:0051240) 2.494KATNB1, RELN, PAFAH1B1, ARX
regulation of cell development (GO:0060284) 3.014KATNB1, RELN, CDK5, PAFAH1B1
multicellular organism development (GO:0007275) 2.544DCX, RELN, PAFAH1B1, ARX
regulation of neuron differentiation (GO:0045664) 3.394KATNB1, RELN, PAFAH1B1, CDK5
organic substance transport (GO:0071702) 2.154APOC3, KATNB1, CDK5, PAFAH1B1
regulation of molecular function (GO:0065009) 1.784APOC3, CDK5, PAFAH1B1, RELN
anatomical structure formation involved in morphogenesis (GO:0048646) 3.014CDK5, RELN, DCX, PAFAH1B1
positive regulation of cellular component organization (GO:0051130) 2.684KATNB1, RELN, PAFAH1B1, CDK5
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.434APOC3, CDK5, RELN, ARX
regulation of catalytic activity (GO:0050790) 1.974APOC3, CDK5, RELN, PAFAH1B1
regulation of biosynthetic process (GO:0009889) 1.374APOC3, CDK5, RELN, ARX
layer formation in cerebral cortex (GO:0021819) 7.244DCX, CDK5, RELN, PAFAH1B1
establishment of protein localization (GO:0045184) 2.534APOC3, KATNB1, CDK5, PAFAH1B1
regulation of cell differentiation (GO:0045595) 2.424KATNB1, RELN, PAFAH1B1, CDK5
regulation of nitrogen compound metabolic process (GO:0051171) 1.364APOC3, CDK5, RELN, ARX
regulation of neuron projection development (GO:0010975) 3.694KATNB1, RELN, PAFAH1B1, CDK5
establishment of localization in cell (GO:0051649) 2.474TUBA1A, KATNB1, PAFAH1B1, CDK5
regulation of intracellular signal transduction (GO:1902531) 2.314APOC3, CDK5, RELN, PAFAH1B1
regulation of phosphorylation (GO:0042325) 2.54APOC3, CDK5, RELN, PAFAH1B1
regulation of phosphorus metabolic process (GO:0051174) 2.354APOC3, CDK5, RELN, PAFAH1B1
nervous system development (GO:0007399) 3.534DCX, CDK5, PAFAH1B1, ARX
intracellular transport (GO:0046907) 2.674TUBA1A, KATNB1, PAFAH1B1, CDK5
positive regulation of developmental process (GO:0051094) 2.774KATNB1, RELN, PAFAH1B1, ARX
regulation of macromolecule metabolic process (GO:0060255) 1.084CDK5, RELN, PAFAH1B1, ARX
response to stimulus (GO:0050896) 1.224APOC3, CDK5, RELN, DCX
phosphate-containing compound metabolic process (GO:0006796) 2.164DCX, CDK5, RELN, PAFAH1B1
regulation of nervous system development (GO:0051960) 3.14KATNB1, RELN, PAFAH1B1, CDK5
regulation of multicellular organismal development (GO:2000026) 2.314KATNB1, RELN, PAFAH1B1, CDK5
phosphorus metabolic process (GO:0006793) 2.154DCX, CDK5, RELN, PAFAH1B1
single-organism cellular localization (GO:1902580) 3.164KATNB1, RELN, CDK5, PAFAH1B1
regulation of transport (GO:0051049) 2.243APOC3, CDK5, RELN
cell development (GO:0048468) 3.283CDK5, DCX, PAFAH1B1
behavior (GO:0007610) 3.473CDK5, RELN, PAFAH1B1
learning or memory (GO:0007611) 4.333CDK5, RELN, PAFAH1B1
membrane organization (GO:0061024) 3.043CDK5, RELN, PAFAH1B1
signal transduction (GO:0007165) 1.283APOC3, DCX, RELN
establishment of organelle localization (GO:0051656) 4.153KATNB1, CDK5, PAFAH1B1
positive regulation of cell projection organization (GO:0031346) 3.993KATNB1, RELN, PAFAH1B1
negative regulation of macromolecule metabolic process (GO:0010605) 2.013CDK5, PAFAH1B1, ARX
positive regulation of macromolecule metabolic process (GO:0010604) 1.813CDK5, RELN, ARX
regulation of cytoskeleton organization (GO:0051493) 3.723KATNB1, CDK5, PAFAH1B1
peptidyl-amino acid modification (GO:0018193) 2.983CDK5, DCX, RELN
regulation of dendritic spine development (GO:0060998) 5.73CDK5, RELN, PAFAH1B1
positive regulation of neuron differentiation (GO:0045666) 3.983KATNB1, RELN, PAFAH1B1
positive regulation of cell development (GO:0010720) 3.573KATNB1, RELN, PAFAH1B1
positive regulation of neuron projection development (GO:0010976) 4.263KATNB1, RELN, PAFAH1B1
regulation of RNA biosynthetic process (GO:2001141) 1.553CDK5, RELN, ARX
neuron projection guidance (GO:0097485) 4.433CDK5, RELN, ARX
system process (GO:0003008) 2.33CDK5, RELN, PAFAH1B1
animal organ development (GO:0048513) 2.533DCX, RELN, PAFAH1B1
protein metabolic process (GO:0019538) 1.453CDK5, RELN, DCX
single-organism behavior (GO:0044708) 3.793CDK5, RELN, PAFAH1B1
regulation of cell morphogenesis (GO:0022604) 3.43CDK5, RELN, PAFAH1B1
cellular component assembly (GO:0022607) 2.143APOC3, CDK5, PAFAH1B1
negative regulation of biosynthetic process (GO:0009890) 2.473APOC3, CDK5, ARX
regulation of anatomical structure morphogenesis (GO:0022603) 2.793CDK5, RELN, PAFAH1B1
regulation of dendritic spine morphogenesis (GO:0061001) 6.333CDK5, RELN, PAFAH1B1
neuron projection development (GO:0031175) 4.583LAMB1, CDK5, RELN
cellular protein metabolic process (GO:0044267) 1.633CDK5, RELN, DCX
organic substance catabolic process (GO:1901575) 2.453APOC3, CDK5, PAFAH1B1
regulation of biological quality (GO:0065008) 1.683APOC3, CDK5, RELN
response to stress (GO:0006950) 1.83APOC3, CDK5, RELN
protein modification process (GO:0036211) 1.793CDK5, RELN, DCX
single-organism membrane organization (GO:0044802) 3.193CDK5, RELN, PAFAH1B1
brain development (GO:0007420) 4.243DCX, RELN, PAFAH1B1
cognition (GO:0050890) 4.23CDK5, RELN, PAFAH1B1
macromolecule modification (GO:0043412) 1.733CDK5, DCX, RELN
regulation of transcription, DNA-templated (GO:0006355) 1.563CDK5, RELN, ARX
neuron projection morphogenesis (GO:0048812) 4.343CDK5, DCX, PAFAH1B1
regulation of cell motility (GO:2000145) 3.163LAMB1, CDK5, RELN
regulation of dendrite morphogenesis (GO:0048814) 5.413CDK5, RELN, PAFAH1B1
regulation of developmental growth (GO:0048638) 4.043CDK5, PAFAH1B1, ARX
regulation of organelle organization (GO:0033043) 2.723KATNB1, CDK5, PAFAH1B1
phosphorylation (GO:0016310) 2.633CDK5, DCX, RELN
axon guidance (GO:0007411) 4.443CDK5, RELN, ARX
cell cycle (GO:0007049) 3.143KATNB1, CDK5, PAFAH1B1
negative regulation of multicellular organismal process (GO:0051241) 2.843APOC3, CDK5, PAFAH1B1
regulation of protein metabolic process (GO:0051246) 1.933CDK5, RELN, PAFAH1B1
positive regulation of neurogenesis (GO:0050769) 3.773KATNB1, RELN, PAFAH1B1
regulation of cell morphogenesis involved in differentiation (GO:0010769) 3.913CDK5, RELN, PAFAH1B1
regulation of protein modification process (GO:0031399) 2.323CDK5, RELN, PAFAH1B1
biological adhesion (GO:0022610) 2.813LAMB1, CDK5, RELN
cell proliferation (GO:0008283) 3.233CDK5, PAFAH1B1, ARX
neurological system process (GO:0050877) 2.643CDK5, RELN, PAFAH1B1
regulation of nucleic acid-templated transcription (GO:1903506) 1.553CDK5, RELN, ARX
positive regulation of cell differentiation (GO:0045597) 3.013KATNB1, RELN, PAFAH1B1
regulation of locomotion (GO:0040012) 3.123LAMB1, CDK5, RELN
axonogenesis (GO:0007409) 4.743CDK5, DCX, PAFAH1B1
cell part morphogenesis (GO:0032990) 3.993CDK5, DCX, PAFAH1B1
regulation of cellular protein metabolic process (GO:0032268) 1.993CDK5, RELN, PAFAH1B1
regulation of dendrite development (GO:0050773) 4.933CDK5, RELN, PAFAH1B1
microtubule-based process (GO:0007017) 3.543TUBA1A, KATNB1, PAFAH1B1
regulation of RNA metabolic process (GO:0051252) 1.523CDK5, RELN, ARX
negative regulation of cellular biosynthetic process (GO:0031327) 2.493APOC3, CDK5, ARX
positive regulation of cellular metabolic process (GO:0031325) 1.813APOC3, CDK5, RELN
mitotic cell cycle process (GO:1903047) 3.123TUBA1A, KATNB1, PAFAH1B1
cell cycle process (GO:0022402) 2.753TUBA1A, KATNB1, PAFAH1B1
cerebral cortex development (GO:0021987) 5.573CDK5, RELN, PAFAH1B1
positive regulation of nervous system development (GO:0051962) 3.643KATNB1, RELN, PAFAH1B1
regulation of growth (GO:0040008) 3.263CDK5, PAFAH1B1, ARX
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.463CDK5, RELN, ARX
regulation of macromolecule biosynthetic process (GO:0010556) 1.433CDK5, RELN, ARX
regulation of gene expression (GO:0010468) 1.373CDK5, RELN, ARX
neuron development (GO:0048666) 4.83CDK5, DCX, PAFAH1B1
protein phosphorylation (GO:0006468) 2.893CDK5, DCX, RELN
regulation of cell migration (GO:0030334) 3.233LAMB1, CDK5, RELN
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.553APOC3, CDK5, ARX
cellular protein modification process (GO:0006464) 1.793CDK5, RELN, DCX
single-organism transport (GO:0044765) 2.183APOC3, CDK5, PAFAH1B1
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.473APOC3, CDK5, ARX
cell adhesion (GO:0007155) 2.823LAMB1, CDK5, RELN
catabolic process (GO:0009056) 2.383APOC3, CDK5, PAFAH1B1
organelle localization (GO:0051640) 3.943KATNB1, CDK5, PAFAH1B1
organelle organization (GO:0006996) 2.023KATNB1, CDK5, PAFAH1B1
regulation of cellular component movement (GO:0051270) 3.083LAMB1, CDK5, RELN
cell projection morphogenesis (GO:0048858) 4.053CDK5, DCX, PAFAH1B1
forebrain development (GO:0030900) 5.483CDK5, RELN, ARX
protein transport (GO:0015031) 2.623KATNB1, CDK5, PAFAH1B1
regulation of protein phosphorylation (GO:0001932) 2.573CDK5, RELN, PAFAH1B1
axon extension (GO:0048675) 6.122CDK5, DCX
response to abiotic stimulus (GO:0009628) 2.82CDK5, DCX
developmental growth (GO:0048589) 4.052CDK5, DCX
developmental cell growth (GO:0048588) 5.372CDK5, DCX
G2/M transition of mitotic cell cycle (GO:0000086) 4.842TUBA1A, PAFAH1B1
positive regulation of response to stimulus (GO:0048584) 2.182RELN, PAFAH1B1
learning (GO:0007612) 4.852CDK5, RELN
neuron differentiation (GO:0030182) 4.172CDK5, PAFAH1B1
regulation of extent of cell growth (GO:0061387) 5.092CDK5, PAFAH1B1
negative regulation of cell projection organization (GO:0031345) 4.722CDK5, PAFAH1B1
establishment of vesicle localization (GO:0051650) 4.912CDK5, PAFAH1B1
single-organism catabolic process (GO:0044712) 3.212APOC3, PAFAH1B1
single-organism metabolic process (GO:0044710) 1.632APOC3, PAFAH1B1
cellular macromolecule localization (GO:0070727) 3.12CDK5, RELN
positive regulation of signal transduction (GO:0009967) 2.52RELN, PAFAH1B1
positive regulation of cytoskeleton organization (GO:0051495) 4.582KATNB1, CDK5
telencephalon cell migration (GO:0022029) 5.992RELN, ARX
negative regulation of neuron differentiation (GO:0045665) 4.452CDK5, PAFAH1B1
positive regulation of dendritic spine development (GO:0060999) 6.172RELN, PAFAH1B1
positive regulation of molecular function (GO:0044093) 2.232CDK5, RELN
negative regulation of cell development (GO:0010721) 4.022CDK5, PAFAH1B1
regulation of cell proliferation (GO:0042127) 2.412LAMB1, ARX
regulation of small GTPase mediated signal transduction (GO:0051056) 4.082APOC3, RELN
cell-substrate adhesion (GO:0031589) 4.752LAMB1, CDK5
neuron projection extension (GO:1990138) 5.742CDK5, DCX
negative regulation of transport (GO:0051051) 3.62APOC3, CDK5
positive regulation of transport (GO:0051050) 2.92CDK5, RELN
regulation of protein kinase activity (GO:0045859) 3.152CDK5, RELN
negative regulation of neuron projection development (GO:0010977) 4.882CDK5, PAFAH1B1
protein localization to membrane (GO:0072657) 3.952CDK5, RELN
localization within membrane (GO:0051668) 5.622CDK5, RELN
regulation of axon extension (GO:0030516) 5.242CDK5, PAFAH1B1
glycerolipid metabolic process (GO:0046486) 3.912APOC3, PAFAH1B1
response to organic substance (GO:0010033) 2.22APOC3, CDK5
single organism signaling (GO:0044700) 3.252CDK5, PAFAH1B1
positive regulation of phosphorylation (GO:0042327) 2.92CDK5, RELN
negative regulation of phosphorylation (GO:0042326) 3.72APOC3, PAFAH1B1
peptidyl-serine modification (GO:0018209) 4.722CDK5, DCX
response to organonitrogen compound (GO:0010243) 3.22APOC3, CDK5
positive regulation of organelle organization (GO:0010638) 3.382KATNB1, CDK5
anterograde trans-synaptic signaling (GO:0098916) 3.982CDK5, PAFAH1B1
regulation of microtubule cytoskeleton organization (GO:0070507) 4.982KATNB1, PAFAH1B1
regulation of membrane potential (GO:0042391) 3.892CDK5, RELN
glial cell differentiation (GO:0010001) 5.482CDK5, RELN
positive regulation of kinase activity (GO:0033674) 3.542CDK5, RELN
positive regulation of dendritic spine morphogenesis (GO:0061003) 7.092RELN, PAFAH1B1
negative regulation of gene expression (GO:0010629) 2.482CDK5, ARX
nitrogen compound metabolic process (GO:0006807) 1.132PAFAH1B1, ARX
actin filament-based process (GO:0030029) 3.942CDK5, PAFAH1B1
mitotic nuclear division (GO:0007067) 4.052KATNB1, PAFAH1B1
protein localization to synapse (GO:0035418) 6.962CDK5, RELN
cell morphogenesis involved in differentiation (GO:0000904) 4.672LAMB1, RELN
positive regulation of transferase activity (GO:0051347) 3.312CDK5, RELN
cell morphogenesis (GO:0000902) 4.352LAMB1, RELN
intracellular protein transport (GO:0006886) 3.22KATNB1, CDK5
regulation of kinase activity (GO:0043549) 3.072CDK5, RELN
lipid catabolic process (GO:0016042) 4.212APOC3, PAFAH1B1
positive regulation of catalytic activity (GO:0043085) 2.42CDK5, RELN
positive regulation of receptor activity (GO:2000273) 5.972CDK5, RELN
negative regulation of developmental process (GO:0051093) 3.172CDK5, PAFAH1B1
organ morphogenesis (GO:0009887) 3.552LAMB1, PAFAH1B1
lipid metabolic process (GO:0006629) 2.682APOC3, PAFAH1B1
associative learning (GO:0008306) 5.442CDK5, RELN
secretion by cell (GO:0032940) 3.592CDK5, PAFAH1B1
regulation of hydrolase activity (GO:0051336) 2.532APOC3, PAFAH1B1
secretion (GO:0046903) 3.382CDK5, PAFAH1B1
positive regulation of protein kinase activity (GO:0045860) 3.612CDK5, RELN
negative regulation of protein modification process (GO:0031400) 3.42CDK5, PAFAH1B1
positive regulation of protein modification process (GO:0031401) 2.72CDK5, RELN
regulation of transferase activity (GO:0051338) 2.882CDK5, RELN
dendrite morphogenesis (GO:0048813) 6.262CDK5, DCX
positive regulation of cell motility (GO:2000147) 3.742LAMB1, RELN
negative regulation of nervous system development (GO:0051961) 4.152CDK5, PAFAH1B1
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532CDK5, ARX
synaptic signaling (GO:0099536) 3.982CDK5, PAFAH1B1
trans-synaptic signaling (GO:0099537) 3.982CDK5, PAFAH1B1
positive regulation of developmental growth (GO:0048639) 4.672PAFAH1B1, ARX
regulation of synapse structure or activity (GO:0050803) 4.772CDK5, RELN
modulation of synaptic transmission (GO:0050804) 4.092CDK5, RELN
positive regulation of signaling (GO:0023056) 2.412RELN, PAFAH1B1
signaling (GO:0023052) 3.252CDK5, PAFAH1B1
forebrain cell migration (GO:0021885) 5.922RELN, ARX
cell communication (GO:0007154) 3.042CDK5, PAFAH1B1
regulation of microtubule-based process (GO:0032886) 4.792KATNB1, PAFAH1B1
positive regulation of cell communication (GO:0010647) 2.412RELN, PAFAH1B1
protein autophosphorylation (GO:0046777) 4.462CDK5, DCX
response to organic cyclic compound (GO:0014070) 3.072APOC3, CDK5
central nervous system development (GO:0007417) 4.842DCX, RELN
response to endogenous stimulus (GO:0009719) 2.792APOC3, CDK5
negative regulation of protein metabolic process (GO:0051248) 2.822CDK5, PAFAH1B1
positive regulation of phosphorus metabolic process (GO:0010562) 2.782CDK5, RELN
negative regulation of phosphorus metabolic process (GO:0010563) 3.452APOC3, PAFAH1B1
nuclear division (GO:0000280) 3.852KATNB1, PAFAH1B1
positive regulation of protein metabolic process (GO:0051247) 2.432CDK5, RELN
negative regulation of neurogenesis (GO:0050768) 4.222CDK5, PAFAH1B1
cytoskeleton-dependent intracellular transport (GO:0030705) 4.962TUBA1A, PAFAH1B1
positive regulation of cellular protein metabolic process (GO:0032270) 2.492CDK5, RELN
central nervous system neuron axonogenesis (GO:0021955) 6.512DCX, PAFAH1B1
central nervous system neuron development (GO:0021954) 6.262CDK5, DCX
developmental growth involved in morphogenesis (GO:0060560) 5.152CDK5, DCX
cerebral cortex cell migration (GO:0021795) 6.362RELN, ARX
central nervous system projection neuron axonogenesis (GO:0021952) 6.732DCX, PAFAH1B1
positive regulation of cellular component movement (GO:0051272) 3.712LAMB1, RELN
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712CDK5, ARX
negative regulation of cell differentiation (GO:0045596) 3.332CDK5, PAFAH1B1
regulation of cell growth (GO:0001558) 3.752CDK5, PAFAH1B1
negative regulation of transcription, DNA-templated (GO:0045892) 2.752CDK5, ARX
cellular lipid metabolic process (GO:0044255) 2.922APOC3, PAFAH1B1
positive regulation of dendrite morphogenesis (GO:0050775) 6.262RELN, PAFAH1B1
negative regulation of cellular protein metabolic process (GO:0032269) 2.882CDK5, PAFAH1B1
regulation of axonogenesis (GO:0050770) 4.592CDK5, PAFAH1B1
negative regulation of RNA metabolic process (GO:0051253) 2.662CDK5, ARX
regulation of synaptic plasticity (GO:0048167) 4.782CDK5, RELN
positive regulation of cell morphogenesis involved in differentiation (GO:0010770) 4.652RELN, PAFAH1B1
cerebral cortex tangential migration (GO:0021800) 7.782RELN, ARX
response to nitrogen compound (GO:1901698) 3.122APOC3, CDK5
peptidyl-serine phosphorylation (GO:0018105) 4.822CDK5, DCX
positive regulation of growth (GO:0045927) 4.252PAFAH1B1, ARX
cell cycle G2/M phase transition (GO:0044839) 4.822TUBA1A, PAFAH1B1
actin cytoskeleton organization (GO:0030036) 4.12CDK5, PAFAH1B1
cell cycle phase transition (GO:0044770) 4.242TUBA1A, PAFAH1B1
mitotic cell cycle phase transition (GO:0044772) 4.272TUBA1A, PAFAH1B1
cortical cytoskeleton organization (GO:0030865) 6.152CDK5, PAFAH1B1
positive regulation of cell death (GO:0010942) 3.322KATNB1, CDK5
regulation of cell death (GO:0010941) 2.432KATNB1, CDK5
growth (GO:0040007) 3.82CDK5, DCX
positive regulation of dendrite development (GO:1900006) 5.572RELN, PAFAH1B1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62CDK5, ARX
neural precursor cell proliferation (GO:0061351) 5.72PAFAH1B1, ARX
regulation of receptor activity (GO:0010469) 4.982CDK5, RELN
positive regulation of cell migration (GO:0030335) 3.772LAMB1, RELN
positive regulation of phosphate metabolic process (GO:0045937) 2.782CDK5, RELN
negative regulation of phosphate metabolic process (GO:0045936) 3.452APOC3, PAFAH1B1
cellular protein localization (GO:0034613) 3.112CDK5, RELN
negative regulation of RNA biosynthetic process (GO:1902679) 2.72CDK5, ARX
vesicle localization (GO:0051648) 4.852CDK5, PAFAH1B1
chemical synaptic transmission (GO:0007268) 3.982CDK5, PAFAH1B1
cell-cell signaling (GO:0007267) 3.352CDK5, PAFAH1B1
response to chemical (GO:0042221) 1.982APOC3, CDK5
regulation of vesicle-mediated transport (GO:0060627) 3.632APOC3, CDK5
cellular catabolic process (GO:0044248) 2.622APOC3, CDK5
response to oxygen-containing compound (GO:1901700) 2.572APOC3, CDK5
adult behavior (GO:0030534) 4.792CDK5, PAFAH1B1
cytoskeleton organization (GO:0007010) 3.222CDK5, PAFAH1B1
positive regulation of locomotion (GO:0040017) 3.712LAMB1, RELN
regulation of cell cycle (GO:0051726) 2.932CDK5, PAFAH1B1
microtubule-based movement (GO:0007018) 4.392KATNB1, PAFAH1B1
single-organism organelle organization (GO:1902589) 2.682CDK5, PAFAH1B1
cell growth (GO:0016049) 4.832CDK5, DCX
organelle fission (GO:0048285) 3.792KATNB1, PAFAH1B1
receptor clustering (GO:0043113) 6.022CDK5, RELN
positive regulation of protein phosphorylation (GO:0001934) 2.952CDK5, RELN

NET-GE enrichment

Term New enriched termICP valueGenes
axon extension (GO:0048675) -6.120.014CDK5, DCX, PAFAH1B1
regulation of neuron projection development (GO:0010975) -3.690.005KATNB1, RELN, PAFAH1B1, CDK5
cell projection organization (GO:0030030) -3.140.003DCX, LAMB1, RELN, CDK5, PAFAH1B1
regulation of dendritic spine morphogenesis (GO:0061001) -6.330.038CDK5, RELN
cellular component movement (GO:0006928) -2.610.0PAFAH1B1, KATNB1, DCX, ARX, CDK5, LAMB1, RELN
hippocampus development (GO:0021766) -5.60.042CDK5, RELN, PAFAH1B1
cerebral cortex cell migration (GO:0021795) -6.360.0TUBA1A, RELN, PAFAH1B1, ARX, CDK5
neuron migration (GO:0001764) -5.00.0PAFAH1B1, DCX, TUBA1A, ARX, CDK5, RELN
forebrain cell migration (GO:0021885) -5.920.0TUBA1A, RELN, PAFAH1B1, ARX, CDK5
neuron projection development (GO:0031175) -4.580.028LAMB1, CDK5, RELN
axon guidance (GO:0007411) -4.440.0PAFAH1B1, LAMB1, DCX, TUBA1A, ARX, CDK5, RELN
regulation of cell projection organization (GO:0031344) -3.380.024PAFAH1B1, KATNB1, TUBA1A, CDK5, LAMB1, RELN
cell division (GO:0051301) -3.680.023TUBA1A, CDK5, PAFAH1B1
positive regulation of cell projection organization (GO:0031346) -3.990.021LAMB1, RELN, KATNB1, PAFAH1B1, CDK5
cell growth (GO:0016049) -4.830.044DCX, LAMB1, CDK5, PAFAH1B1
cellular component morphogenesis (GO:0032989) -3.50.001PAFAH1B1, LAMB1, DCX, TUBA1A, CDK5, RELN
regulation of neuron differentiation (GO:0045664) -3.390.023KATNB1, RELN, CDK5, PAFAH1B1
negative regulation of cellular component organization (GO:0051129) -3.350.042APOC3, KATNB1, CDK5, PAFAH1B1
neural precursor cell proliferation (GO:0061351) -5.70.036TUBA1A, PAFAH1B1, ARX
central nervous system neuron axonogenesis (GO:0021955) -6.510.009CDK5, DCX, PAFAH1B1
cell migration (GO:0016477) -3.120.0PAFAH1B1, LAMB1, DCX, TUBA1A, ARX, CDK5, RELN
anatomical structure formation involved in morphogenesis (GO:0048646) -3.010.044PAFAH1B1, LAMB1, DCX, TUBA1A, ARX, CDK5, RELN
central nervous system projection neuron axonogenesis (GO:0021952) -6.730.004CDK5, DCX, PAFAH1B1
positive regulation of cellular component organization (GO:0051130) -2.680.001PAFAH1B1, LAMB1, DCX, APOC3, TUBA1A, CDK5, KATNB1, RELN
neuron projection extension (GO:1990138) -5.740.025CDK5, DCX, PAFAH1B1
neurological system process (GO:0050877) -2.640.036PAFAH1B1, LAMB1, DCX, TUBA1A, ARX, CDK5, RELN
layer formation in cerebral cortex (GO:0021819) -7.240.0CDK5, RELN, PAFAH1B1
positive regulation of neuron projection development (GO:0010976) -4.260.009KATNB1, RELN, PAFAH1B1, CDK5
axonogenesis (GO:0007409) -4.740.032DCX, TUBA1A, CDK5, PAFAH1B1
system development (GO:0048731) -2.920.037PAFAH1B1, LAMB1, DCX, TUBA1A, ARX, CDK5, RELN
neuron projection guidance (GO:0097485) -4.430.0PAFAH1B1, LAMB1, DCX, TUBA1A, ARX, CDK5, RELN
telencephalon cell migration (GO:0022029) -5.990.0TUBA1A, RELN, PAFAH1B1, ARX, CDK5
locomotion (GO:0040011) -2.910.001PAFAH1B1, LAMB1, DCX, ARX, CDK5, RELN
single organism signaling (GO:0044700) -3.250.015PAFAH1B1, LAMB1, DCX, TUBA1A, ARX, CDK5, RELN
regulation of dendrite development (GO:0050773) -4.930.016LAMB1, RELN, CDK5, PAFAH1B1
nervous system development (GO:0007399) -3.530.0PAFAH1B1, LAMB1, DCX, TUBA1A, ARX, CDK5, RELN
cell motility (GO:0048870) -3.020.0PAFAH1B1, LAMB1, DCX, TUBA1A, ARX, CDK5, RELN
protein localization to synapse (GO:0035418) -6.960.024CDK5, RELN
cell proliferation in forebrain (GO:0021846) NEW6.960.001TUBA1A, PAFAH1B1, ARX
dendrite morphogenesis (GO:0048813) -6.260.0DCX, TUBA1A, CDK5, PAFAH1B1
regulation of dendrite morphogenesis (GO:0048814) -5.410.001LAMB1, RELN, CDK5, PAFAH1B1
signaling (GO:0023052) -3.250.015PAFAH1B1, LAMB1, DCX, TUBA1A, ARX, CDK5, RELN
receptor clustering (GO:0043113) -6.020.017CDK5, RELN, PAFAH1B1
cerebral cortex tangential migration (GO:0021800) -7.780.0TUBA1A, RELN, PAFAH1B1, ARX
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.289PAFAH1B1, KATNB1, DCX, APOC3, TUBA1A, ARX, CDK5, LAMB1, RELN
cell part (GO:0044464) 0.119PAFAH1B1, KATNB1, DCX, APOC3, TUBA1A, ARX, CDK5, LAMB1, RELN
membrane-bounded organelle (GO:0043227) 0.478PAFAH1B1, LAMB1, DCX, APOC3, TUBA1A, ARX, CDK5, KATNB1
organelle (GO:0043226) 0.48PAFAH1B1, LAMB1, DCX, APOC3, TUBA1A, ARX, CDK5, KATNB1
cytoplasmic part (GO:0044444) 0.827PAFAH1B1, KATNB1, DCX, APOC3, TUBA1A, CDK5, LAMB1
intracellular organelle (GO:0043229) 0.517PAFAH1B1, KATNB1, DCX, APOC3, TUBA1A, ARX, CDK5
macromolecular complex (GO:0032991) 1.357PAFAH1B1, KATNB1, DCX, APOC3, TUBA1A, CDK5, LAMB1
intracellular membrane-bounded organelle (GO:0043231) 0.67PAFAH1B1, KATNB1, DCX, APOC3, TUBA1A, ARX, CDK5
cytoplasm (GO:0005737) 1.016PAFAH1B1, KATNB1, DCX, TUBA1A, CDK5, RELN
nucleus (GO:0005634) 1.076PAFAH1B1, KATNB1, DCX, TUBA1A, ARX, CDK5
protein complex (GO:0043234) 1.515DCX, LAMB1, KATNB1, PAFAH1B1, CDK5
cytoskeleton (GO:0005856) 2.555DCX, TUBA1A, KATNB1, PAFAH1B1, CDK5
intracellular non-membrane-bounded organelle (GO:0043232) 1.765DCX, TUBA1A, KATNB1, PAFAH1B1, CDK5
intracellular organelle part (GO:0044446) 0.815DCX, TUBA1A, KATNB1, PAFAH1B1, CDK5
neuron part (GO:0097458) 2.645DCX, KATNB1, RELN, PAFAH1B1, CDK5
non-membrane-bounded organelle (GO:0043228) 1.765DCX, TUBA1A, KATNB1, PAFAH1B1, CDK5
neuron projection (GO:0043005) 3.125DCX, KATNB1, RELN, PAFAH1B1, CDK5
cell projection (GO:0042995) 2.475DCX, KATNB1, RELN, PAFAH1B1, CDK5
extracellular region part (GO:0044421) 1.575APOC3, LAMB1, RELN, TUBA1A, PAFAH1B1
organelle part (GO:0044422) 0.795DCX, TUBA1A, KATNB1, PAFAH1B1, CDK5
extracellular organelle (GO:0043230) 1.894APOC3, LAMB1, TUBA1A, PAFAH1B1
polymeric cytoskeletal fiber (GO:0099513) 3.314DCX, TUBA1A, KATNB1, PAFAH1B1
extracellular exosome (GO:0070062) 1.894APOC3, LAMB1, TUBA1A, PAFAH1B1
cytosol (GO:0005829) 1.684DCX, TUBA1A, CDK5, PAFAH1B1
membrane (GO:0016020) 0.684KATNB1, RELN, CDK5, PAFAH1B1
membrane-bounded vesicle (GO:0031988) 1.714APOC3, LAMB1, TUBA1A, PAFAH1B1
cytoskeletal part (GO:0044430) 2.494DCX, TUBA1A, KATNB1, PAFAH1B1
supramolecular fiber (GO:0099512) 3.314DCX, TUBA1A, KATNB1, PAFAH1B1
extracellular vesicle (GO:1903561) 1.894APOC3, LAMB1, TUBA1A, PAFAH1B1
microtubule (GO:0005874) 3.814DCX, TUBA1A, KATNB1, PAFAH1B1
vesicle (GO:0031982) 1.644APOC3, LAMB1, TUBA1A, PAFAH1B1
extracellular space (GO:0005615) 2.633APOC3, LAMB1, RELN
site of polarized growth (GO:0030427) 4.853KATNB1, CDK5, PAFAH1B1
cell projection part (GO:0044463) 2.973KATNB1, CDK5, PAFAH1B1
cell body (GO:0044297) 3.743KATNB1, CDK5, PAFAH1B1
growth cone (GO:0030426) 4.893KATNB1, CDK5, PAFAH1B1
dendrite (GO:0030425) 3.923CDK5, DCX, RELN
axon (GO:0030424) 4.153KATNB1, CDK5, PAFAH1B1
extracellular region (GO:0005576) 2.183APOC3, LAMB1, RELN
plasma membrane (GO:0005886) 1.393KATNB1, CDK5, RELN
neuronal cell body (GO:0043025) 3.93KATNB1, CDK5, PAFAH1B1
microtubule associated complex (GO:0005875) 4.793KATNB1, DCX, PAFAH1B1
spindle (GO:0005819) 4.522KATNB1, PAFAH1B1
vacuole (GO:0005773) 2.922APOC3, TUBA1A
centrosome (GO:0005813) 3.752KATNB1, PAFAH1B1
extracellular matrix (GO:0031012) 3.812LAMB1, RELN
cytoplasmic microtubule (GO:0005881) 5.742TUBA1A, PAFAH1B1
microtubule cytoskeleton (GO:0015630) 4.782KATNB1, PAFAH1B1
nuclear part (GO:0044428) 1.552CDK5, PAFAH1B1
perinuclear region of cytoplasm (GO:0048471) 3.352LAMB1, PAFAH1B1
microtubule organizing center (GO:0005815) 3.422KATNB1, PAFAH1B1
endosome (GO:0005768) 3.252APOC3, TUBA1A
proteinaceous extracellular matrix (GO:0005578) 4.012LAMB1, RELN

NET-GE enrichment

Term New enriched termICP valueGenes
protein-lipid complex (GO:0032994) NEW6.110.002APOC3, CDK5, PAFAH1B1
low-density lipoprotein particle (GO:0034362) NEW7.160.013APOC3, PAFAH1B1
cell body (GO:0044297) -3.740.033KATNB1, CDK5, PAFAH1B1
site of polarized growth (GO:0030427) -4.850.002KATNB1, CDK5, PAFAH1B1
growth cone (GO:0030426) -4.890.002KATNB1, CDK5, PAFAH1B1
cell leading edge (GO:0031252) NEW6.040.033CDK5, PAFAH1B1
cytoplasmic microtubule (GO:0005881) -5.740.023TUBA1A, PAFAH1B1
neuron part (GO:0097458) -2.640.019PAFAH1B1, KATNB1, DCX, TUBA1A, CDK5, LAMB1, RELN
cytoskeletal part (GO:0044430) -2.490.026DCX, TUBA1A, KATNB1, PAFAH1B1, CDK5
neuronal cell body (GO:0043025) -3.90.021KATNB1, CDK5, PAFAH1B1
neuron projection (GO:0043005) -3.120.009PAFAH1B1, KATNB1, DCX, CDK5, LAMB1, RELN
cell projection (GO:0042995) -2.470.007DCX, KATNB1, RELN, PAFAH1B1, CDK5
microtubule (GO:0005874) -3.810.001DCX, TUBA1A, KATNB1, PAFAH1B1, CDK5
microtubule associated complex (GO:0005875) -4.790.0DCX, TUBA1A, KATNB1, PAFAH1B1, CDK5