Disease table of OROFACIAL CLEFT OMIM ID: PS119530

Gene-disease associations table

GeneAssociated with OROFACIAL CLEFT inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
TP63ClinVar, OMIM, HUMSAVARHGNC link3q286106260, 103285, 604292, PS119530, PS183600, 603543
BMP4ClinVar, OMIM, HUMSAVARHGNC link14q22.22PS309800, PS119530
IRF6OMIM, HUMSAVARHGNC link1q32.23PS119530, 119300, 119500
SUMO1OMIMHGNC link2q33.11PS119530
NECTIN1ClinVar, OMIMHGNC link11q23.31PS119530
MSX1ClinVar, OMIM, HUMSAVARHGNC link4p16.23PS106600, PS305100, PS119530

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
TP63YES11BAX, TCF4, VDR, KLF4, CDKN1A, FDXR, EVPL, SMARCD3, XPC, PPARA, DDB20
IRF6YES1NR1H40
MSX1YES6HEY1, DLK1, CGA, DKK1, NOTCH3, ZHX20
GATA4NO22NKX2-5, FGF10, HDAC9, CYP17A1, NOS3, CCND2, BMP4, HESX1, HAMP, FCGR3B, STAR, ERBB2, FABP2, IAPP, NPPA, AMH, SUMO1, NPPB, IL5, SGPL1, FCGR2B, MEF2C2BMP4, SUMO1
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
TP63YES3SATB2, BRCA1, STAT30
BMP4YES4POU5F1, FOXL1, ETS1, GATA40
SUMO1YES4YBX1, STAT5A, BCL6, GATA40
MSX1YES2PHOX2B, FOXE10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
TP63SUMO1Yes14DAXX, TP63, SUMO1, FAS, PML, PSMD2, VCP, TP53, HNRNPK, MDM2, BRCA1, YAP1, HIPK2, UBE2I
IRF6SUMO1No1HHV8GK18_GP81

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
TP63BMP4No-4SHH, FGF8, CDKN1A, EGFR
TP63IRF6Yesactivation, binding1SERPINB5
TP63SUMO1No-6MDM2, UBE2A, TP53, UBC, UBE2I, MDM4
TP63MSX1No-3IRF6, FGF8, TP53
BMP4IRF6No-5ATF2, JUN, ICAM1, EGR1, MSX1
BMP4SUMO1No-14GATA4, PCNA, EGR1, CCND1, MAPK8, SMAD4, JUN, SMAD3, CDH1, MITF, NKX2-5, MYB, PAX6, KLF4
BMP4MSX1Yesactivation, binding11LEF1, RUNX2, FGF4, FGF8, PAX3, WNT1, YBX1, BMP2, MYOD1, PAX9, WNT4
IRF6SUMO1No-11CREBBP, NR3C1, ADAR, IRF1, IRF7, EGR1, JUN, SP100, ISG15, FOS, PML
IRF6MSX1Yesbinding1CREBBP
SUMO1MSX1No-2CREBBP, TP53

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: NET-GE enrichment (no shared terms)

NET-GE enrichment

Term New enriched termICP valueGenes
Infectious diseases: ViralNEW3.290.007BMP4, SUMO1, IRF6, MSX1, TP63, PVRL1
Herpes simplex infection (hsa05168) NEW5.080.011IRF6, TP63, SUMO1, PVRL1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Cytokine Signaling in Immune systemR-HSA-12802153.742IRF6, SUMO1
Interferon SignalingR-HSA-9135314.952IRF6, SUMO1
Interferon gamma signalingR-HSA-8773005.672IRF6, SUMO1
Immune SystemR-HSA-1682562.372IRF6, SUMO1

NET-GE enrichment

Term New enriched termICP valueGenes
Phase 1 - Functionalization of compounds (R-HSA-211945) NEW6.70.019IRF6, BMP4, SUMO1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.186BMP4, SUMO1, IRF6, NECTIN1, MSX1, TP63
protein binding (GO:0005515) 0.466BMP4, SUMO1, IRF6, NECTIN1, MSX1, TP63
organic cyclic compound binding (GO:0097159) 1.054MSX1, IRF6, TP63, SUMO1
heterocyclic compound binding (GO:1901363) 1.064MSX1, IRF6, TP63, SUMO1
nucleic acid binding (GO:0003676) 1.444MSX1, IRF6, TP63, SUMO1
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.653IRF6, TP63, MSX1
DNA binding (GO:0003677) 1.923IRF6, MSX1, TP63
regulatory region nucleic acid binding (GO:0001067) 3.033IRF6, MSX1, TP63
nucleic acid binding transcription factor activity (GO:0001071) 2.653IRF6, TP63, MSX1
regulatory region DNA binding (GO:0000975) 3.033IRF6, TP63, MSX1
identical protein binding (GO:0042802) 2.633NECTIN1, BMP4, TP63
sequence-specific DNA binding (GO:0043565) 2.792TP63, MSX1
receptor binding (GO:0005102) 2.432NECTIN1, BMP4
transcription regulatory region DNA binding (GO:0044212) 3.032MSX1, TP63
protein dimerization activity (GO:0046983) 2.722NECTIN1, BMP4
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228) 3.982TP63, MSX1
double-stranded DNA binding (GO:0003690) 3.092MSX1, TP63
p53 binding (GO:0002039) 5.532MSX1, TP63
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0000982) 3.942TP63, MSX1
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.292TP63, MSX1
protein homodimerization activity (GO:0042803) 3.162NECTIN1, BMP4

NET-GE enrichment

Term New enriched termICP valueGenes
sequence-specific DNA binding (GO:0043565) -2.790.026TP63, BMP4, MSX1, SUMO1, IRF6
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription (GO:0001227) NEW4.610.0BMP4, MSX1, SUMO1, TP63
activating transcription factor binding (GO:0033613) NEW5.680.001BMP4, MSX1, SUMO1
transcription regulatory region DNA binding (GO:0044212) -3.030.005MSX1, BMP4, TP63, SUMO1, IRF6
regulatory region nucleic acid binding (GO:0001067) -3.030.005MSX1, BMP4, TP63, SUMO1, IRF6
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001228) -3.980.007BMP4, MSX1, SUMO1, TP63
RNA polymerase II transcription factor binding transcription factor activity (GO:0001076) NEW4.840.029BMP4, MSX1, SUMO1
regulatory region DNA binding (GO:0000975) -3.030.005TP63, BMP4, MSX1, SUMO1, IRF6
p53 binding (GO:0002039) -5.530.01MSX1, TP63, SUMO1
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity (GO:0000982) -3.940.007BMP4, MSX1, SUMO1, TP63
sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0000981) -3.290.002TP63, BMP4, MSX1, SUMO1, IRF6
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
developmental process (GO:0032502) 1.366BMP4, SUMO1, IRF6, NECTIN1, MSX1, TP63
anatomical structure development (GO:0048856) 1.586BMP4, SUMO1, IRF6, NECTIN1, MSX1, TP63
cellular process (GO:0009987) 0.266BMP4, SUMO1, IRF6, NECTIN1, MSX1, TP63
regulation of cellular process (GO:0050794) 0.56BMP4, SUMO1, IRF6, NECTIN1, MSX1, TP63
biological regulation (GO:0065007) 0.396BMP4, SUMO1, IRF6, NECTIN1, MSX1, TP63
regulation of biological process (GO:0050789) 0.456BMP4, SUMO1, IRF6, NECTIN1, MSX1, TP63
positive regulation of metabolic process (GO:0009893) 1.745MSX1, BMP4, TP63, SUMO1, IRF6
regulation of metabolic process (GO:0019222) 1.025MSX1, BMP4, TP63, SUMO1, IRF6
regulation of cellular biosynthetic process (GO:0031326) 1.385MSX1, BMP4, TP63, SUMO1, IRF6
positive regulation of cellular metabolic process (GO:0031325) 1.815MSX1, BMP4, TP63, SUMO1, IRF6
regulation of cellular metabolic process (GO:0031323) 1.075MSX1, BMP4, TP63, SUMO1, IRF6
regulation of cellular component organization (GO:0051128) 2.015BMP4, NECTIN1, MSX1, SUMO1, TP63
metabolic process (GO:0008152) 0.585TP63, BMP4, MSX1, SUMO1, IRF6
signal transduction (GO:0007165) 1.285IRF6, NECTIN1, BMP4, MSX1, TP63
single-organism process (GO:0044699) 0.485IRF6, NECTIN1, MSX1, BMP4, TP63
regulation of primary metabolic process (GO:0080090) 1.085MSX1, BMP4, TP63, SUMO1, IRF6
positive regulation of macromolecule metabolic process (GO:0010604) 1.815TP63, BMP4, MSX1, SUMO1, IRF6
cellular macromolecule metabolic process (GO:0044260) 0.935MSX1, BMP4, TP63, SUMO1, IRF6
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.465TP63, BMP4, MSX1, SUMO1, IRF6
cellular component organization (GO:0016043) 1.245BMP4, NECTIN1, MSX1, SUMO1, TP63
organic substance metabolic process (GO:0071704) 0.635TP63, BMP4, MSX1, SUMO1, IRF6
cellular component organization or biogenesis (GO:0071840) 1.225MSX1, NECTIN1, BMP4, SUMO1, TP63
positive regulation of biological process (GO:0048518) 1.25MSX1, BMP4, TP63, SUMO1, IRF6
negative regulation of biological process (GO:0048519) 1.335TP63, BMP4, MSX1, SUMO1, IRF6
regulation of gene expression (GO:0010468) 1.375MSX1, BMP4, TP63, SUMO1, IRF6
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.435TP63, BMP4, MSX1, SUMO1, IRF6
regulation of biosynthetic process (GO:0009889) 1.375MSX1, BMP4, TP63, SUMO1, IRF6
regulation of nucleic acid-templated transcription (GO:1903506) 1.555MSX1, BMP4, TP63, SUMO1, IRF6
single-organism developmental process (GO:0044767) 1.495MSX1, IRF6, NECTIN1, BMP4, TP63
single-organism cellular process (GO:0044763) 0.655MSX1, IRF6, NECTIN1, BMP4, TP63
regulation of nitrogen compound metabolic process (GO:0051171) 1.365TP63, BMP4, MSX1, SUMO1, IRF6
regulation of multicellular organismal process (GO:0051239) 1.875BMP4, NECTIN1, MSX1, SUMO1, TP63
regulation of RNA biosynthetic process (GO:2001141) 1.555MSX1, BMP4, TP63, SUMO1, IRF6
primary metabolic process (GO:0044238) 0.695MSX1, BMP4, TP63, SUMO1, IRF6
regulation of macromolecule metabolic process (GO:0060255) 1.085MSX1, BMP4, TP63, SUMO1, IRF6
regulation of RNA metabolic process (GO:0051252) 1.525TP63, BMP4, MSX1, SUMO1, IRF6
cellular metabolic process (GO:0044237) 0.695MSX1, BMP4, TP63, SUMO1, IRF6
macromolecule metabolic process (GO:0043170) 0.835TP63, BMP4, MSX1, SUMO1, IRF6
regulation of transcription, DNA-templated (GO:0006355) 1.565TP63, BMP4, MSX1, SUMO1, IRF6
regulation of macromolecule biosynthetic process (GO:0010556) 1.435TP63, BMP4, MSX1, SUMO1, IRF6
negative regulation of cellular process (GO:0048523) 1.415MSX1, BMP4, TP63, SUMO1, IRF6
positive regulation of cellular process (GO:0048522) 1.35TP63, BMP4, MSX1, SUMO1, IRF6
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.564IRF6, BMP4, MSX1, TP63
negative regulation of metabolic process (GO:0009892) 1.934BMP4, MSX1, SUMO1, TP63
negative regulation of biosynthetic process (GO:0009890) 2.474MSX1, BMP4, TP63, SUMO1
positive regulation of biosynthetic process (GO:0009891) 2.294MSX1, IRF6, BMP4, TP63
negative regulation of cellular biosynthetic process (GO:0031327) 2.494MSX1, BMP4, TP63, SUMO1
cell differentiation (GO:0030154) 2.144IRF6, BMP4, MSX1, TP63
regulation of response to stimulus (GO:0048583) 1.544MSX1, BMP4, TP63, SUMO1
nucleic acid metabolic process (GO:0090304) 1.464MSX1, IRF6, TP63, SUMO1
negative regulation of gene expression (GO:0010629) 2.484MSX1, BMP4, TP63, SUMO1
positive regulation of gene expression (GO:0010628) 2.354IRF6, BMP4, MSX1, TP63
cell surface receptor signaling pathway (GO:0007166) 2.094MSX1, IRF6, BMP4, TP63
regulation of signaling (GO:0023051) 1.724MSX1, BMP4, TP63, SUMO1
anatomical structure morphogenesis (GO:0009653) 2.534MSX1, NECTIN1, TP63, BMP4
organic cyclic compound metabolic process (GO:1901360) 1.264MSX1, IRF6, TP63, SUMO1
nucleobase-containing compound metabolic process (GO:0006139) 1.354MSX1, IRF6, TP63, SUMO1
regulation of cell communication (GO:0010646) 1.734BMP4, MSX1, SUMO1, TP63
negative regulation of macromolecule metabolic process (GO:0010605) 2.014MSX1, BMP4, TP63, SUMO1
regulation of signal transduction (GO:0009966) 1.844BMP4, MSX1, SUMO1, TP63
cellular developmental process (GO:0048869) 1.824MSX1, IRF6, BMP4, TP63
positive regulation of cellular biosynthetic process (GO:0031328) 2.34MSX1, IRF6, BMP4, TP63
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.64MSX1, BMP4, TP63, SUMO1
localization (GO:0051179) 1.44BMP4, NECTIN1, MSX1, SUMO1
animal organ development (GO:0048513) 2.534MSX1, IRF6, BMP4, TP63
regulation of molecular function (GO:0065009) 1.784BMP4, MSX1, SUMO1, TP63
regulation of biological quality (GO:0065008) 1.684MSX1, BMP4, TP63, SUMO1
regulation of cell proliferation (GO:0042127) 2.414IRF6, BMP4, MSX1, TP63
organ morphogenesis (GO:0009887) 3.554MSX1, NECTIN1, BMP4, TP63
negative regulation of cellular metabolic process (GO:0031324) 2.014MSX1, BMP4, TP63, SUMO1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.354IRF6, BMP4, MSX1, TP63
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.554MSX1, BMP4, TP63, SUMO1
cell proliferation (GO:0008283) 3.234MSX1, IRF6, BMP4, TP63
regulation of developmental process (GO:0050793) 2.14NECTIN1, BMP4, MSX1, TP63
cellular aromatic compound metabolic process (GO:0006725) 1.34IRF6, MSX1, SUMO1, TP63
tissue development (GO:0009888) 3.274NECTIN1, BMP4, MSX1, TP63
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.714BMP4, MSX1, SUMO1, TP63
negative regulation of RNA biosynthetic process (GO:1902679) 2.74BMP4, MSX1, SUMO1, TP63
negative regulation of transcription, DNA-templated (GO:0045892) 2.754MSX1, BMP4, TP63, SUMO1
positive regulation of transcription, DNA-templated (GO:0045893) 2.564MSX1, IRF6, BMP4, TP63
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.474MSX1, BMP4, TP63, SUMO1
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.294MSX1, IRF6, BMP4, TP63
cellular nitrogen compound metabolic process (GO:0034641) 1.224IRF6, MSX1, SUMO1, TP63
negative regulation of RNA metabolic process (GO:0051253) 2.664BMP4, MSX1, SUMO1, TP63
heterocycle metabolic process (GO:0046483) 1.314IRF6, MSX1, SUMO1, TP63
regulation of cell cycle (GO:0051726) 2.934MSX1, IRF6, BMP4, TP63
response to stimulus (GO:0050896) 1.224BMP4, NECTIN1, TP63, SUMO1
positive regulation of RNA metabolic process (GO:0051254) 2.514IRF6, BMP4, MSX1, TP63
positive regulation of RNA biosynthetic process (GO:1902680) 2.544IRF6, BMP4, MSX1, TP63
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.394MSX1, IRF6, BMP4, TP63
nitrogen compound metabolic process (GO:0006807) 1.134IRF6, MSX1, SUMO1, TP63
regulation of multicellular organismal development (GO:2000026) 2.314MSX1, NECTIN1, BMP4, TP63
positive regulation of cellular component organization (GO:0051130) 2.684BMP4, MSX1, SUMO1, TP63
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.534MSX1, BMP4, TP63, SUMO1
protein localization to nucleus (GO:0034504) 4.93BMP4, MSX1, SUMO1
protein localization (GO:0008104) 2.363BMP4, MSX1, SUMO1
RNA biosynthetic process (GO:0032774) 1.843IRF6, TP63, MSX1
embryonic limb morphogenesis (GO:0030326) 5.243MSX1, BMP4, TP63
regulation of organelle organization (GO:0033043) 2.723MSX1, BMP4, TP63
regulation of transport (GO:0051049) 2.243BMP4, TP63, SUMO1
positive regulation of response to stimulus (GO:0048584) 2.183MSX1, BMP4, TP63
appendage morphogenesis (GO:0035107) 5.053BMP4, MSX1, TP63
positive regulation of signaling (GO:0023056) 2.413MSX1, BMP4, TP63
cellular biosynthetic process (GO:0044249) 1.373IRF6, TP63, MSX1
negative regulation of molecular function (GO:0044092) 2.743BMP4, MSX1, SUMO1
limb morphogenesis (GO:0035108) 5.053BMP4, MSX1, TP63
cellular macromolecule biosynthetic process (GO:0034645) 1.663IRF6, TP63, MSX1
regulation of cell differentiation (GO:0045595) 2.423MSX1, BMP4, TP63
organic substance biosynthetic process (GO:1901576) 1.343IRF6, MSX1, TP63
positive regulation of cell communication (GO:0010647) 2.413MSX1, BMP4, TP63
regulation of cell death (GO:0010941) 2.433BMP4, MSX1, TP63
organic cyclic compound biosynthetic process (GO:1901362) 1.663IRF6, MSX1, TP63
multicellular organism development (GO:0007275) 2.543MSX1, BMP4, TP63
nucleic acid-templated transcription (GO:0097659) 1.913IRF6, MSX1, TP63
regulation of protein localization (GO:0032880) 2.883BMP4, TP63, SUMO1
pattern specification process (GO:0007389) 3.793BMP4, MSX1, TP63
cellular response to stimulus (GO:0051716) 1.973BMP4, TP63, SUMO1
regulation of localization (GO:0032879) 1.943BMP4, TP63, SUMO1
negative regulation of cell cycle (GO:0045786) 3.673IRF6, BMP4, TP63
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.123BMP4, MSX1, TP63
positive regulation of signal transduction (GO:0009967) 2.53MSX1, BMP4, TP63
regulation of apoptotic process (GO:0042981) 2.53BMP4, MSX1, TP63
regulation of cell cycle process (GO:0010564) 3.53BMP4, MSX1, TP63
regulation of programmed cell death (GO:0043067) 2.493MSX1, BMP4, TP63
positive regulation of apoptotic process (GO:0043065) 3.383BMP4, MSX1, TP63
negative regulation of developmental process (GO:0051093) 3.173MSX1, BMP4, TP63
regulation of protein metabolic process (GO:0051246) 1.933BMP4, TP63, SUMO1
negative regulation of apoptotic process (GO:0043066) 3.043MSX1, BMP4, TP63
tissue morphogenesis (GO:0048729) 3.873MSX1, BMP4, TP63
epithelial cell differentiation (GO:0030855) 3.983IRF6, BMP4, TP63
positive regulation of cell death (GO:0010942) 3.323MSX1, BMP4, TP63
macromolecule localization (GO:0033036) 2.343BMP4, MSX1, SUMO1
negative regulation of programmed cell death (GO:0043069) 3.023BMP4, MSX1, TP63
positive regulation of programmed cell death (GO:0043068) 3.383BMP4, MSX1, TP63
heterocycle biosynthetic process (GO:0018130) 1.73IRF6, TP63, MSX1
embryonic morphogenesis (GO:0048598) 3.723BMP4, MSX1, TP63
negative regulation of cell proliferation (GO:0008285) 3.263IRF6, BMP4, MSX1
regulation of catalytic activity (GO:0050790) 1.973BMP4, TP63, SUMO1
positive regulation of transport (GO:0051050) 2.93BMP4, TP63, SUMO1
negative regulation of cell death (GO:0060548) 2.953BMP4, MSX1, TP63
multicellular organismal process (GO:0032501) 1.453MSX1, BMP4, TP63
cellular protein localization (GO:0034613) 3.113BMP4, MSX1, SUMO1
cell development (GO:0048468) 3.283IRF6, BMP4, TP63
negative regulation of cell differentiation (GO:0045596) 3.333BMP4, MSX1, TP63
response to stress (GO:0006950) 1.83BMP4, TP63, SUMO1
macromolecule biosynthetic process (GO:0009059) 1.613IRF6, MSX1, TP63
regionalization (GO:0003002) 4.243MSX1, BMP4, TP63
embryonic appendage morphogenesis (GO:0035113) 5.243BMP4, MSX1, TP63
nucleobase-containing compound biosynthetic process (GO:0034654) 1.723IRF6, MSX1, TP63
odontogenesis of dentin-containing tooth (GO:0042475) 5.523MSX1, BMP4, TP63
regulation of intracellular signal transduction (GO:1902531) 2.313BMP4, MSX1, TP63
cellular localization (GO:0051641) 2.323BMP4, MSX1, SUMO1
RNA metabolic process (GO:0016070) 1.593IRF6, MSX1, TP63
cellular nitrogen compound biosynthetic process (GO:0044271) 1.593IRF6, MSX1, TP63
single-multicellular organism process (GO:0044707) 1.783BMP4, MSX1, TP63
odontogenesis (GO:0042476) 5.193MSX1, BMP4, TP63
regulation of response to stress (GO:0080134) 2.533MSX1, TP63, SUMO1
regulation of binding (GO:0051098) 4.083BMP4, MSX1, SUMO1
biosynthetic process (GO:0009058) 1.323IRF6, TP63, MSX1
epithelial cell proliferation (GO:0050673) 5.213IRF6, BMP4, TP63
cellular macromolecule localization (GO:0070727) 3.13BMP4, MSX1, SUMO1
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.243MSX1, BMP4, TP63
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.813BMP4, MSX1, TP63
transcription, DNA-templated (GO:0006351) 1.913IRF6, TP63, MSX1
cellular response to stress (GO:0033554) 2.513BMP4, TP63, SUMO1
protein localization to organelle (GO:0033365) 3.573BMP4, MSX1, SUMO1
aromatic compound biosynthetic process (GO:0019438) 1.73IRF6, TP63, MSX1
positive regulation of apoptotic signaling pathway (GO:2001235) 4.582TP63, MSX1
regulation of apoptotic signaling pathway (GO:2001233) 3.832TP63, MSX1
negative regulation of response to stimulus (GO:0048585) 2.522BMP4, TP63
regulation of reproductive process (GO:2000241) 4.882BMP4, MSX1
skeletal system development (GO:0001501) 4.492BMP4, TP63
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242BMP4, MSX1
positive regulation of transmembrane transport (GO:0034764) 4.992BMP4, SUMO1
regulation of ion transmembrane transport (GO:0034765) 3.772BMP4, SUMO1
regulation of BMP signaling pathway (GO:0030510) 5.362BMP4, MSX1
positive regulation of ion transmembrane transport (GO:0034767) 5.052BMP4, SUMO1
regulation of transmembrane transport (GO:0034762) 3.742BMP4, SUMO1
stem cell differentiation (GO:0048863) 5.722MSX1, TP63
positive regulation of cell cycle (GO:0045787) 3.942MSX1, TP63
regulation of calcium ion transmembrane transporter activity (GO:1901019) 5.492BMP4, SUMO1
interspecies interaction between organisms (GO:0044419) 3.082NECTIN1, SUMO1
regulation of osteoblast differentiation (GO:0045667) 4.992BMP4, TP63
regulation of epithelial cell differentiation (GO:0030856) 4.962BMP4, TP63
positive regulation of molecular function (GO:0044093) 2.232BMP4, SUMO1
regulation of signal transduction by p53 class mediator (GO:1901796) 4.632MSX1, TP63
transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0007178) 4.62BMP4, MSX1
positive regulation of osteoblast differentiation (GO:0045669) 5.622BMP4, TP63
epithelial cell development (GO:0002064) 4.922BMP4, TP63
keratinocyte differentiation (GO:0030216) 5.372IRF6, TP63
developmental process involved in reproduction (GO:0003006) 3.362BMP4, TP63
regulation of proteolysis (GO:0030162) 3.22TP63, SUMO1
positive regulation of BMP signaling pathway (GO:0030513) 6.262BMP4, MSX1
multi-organism process (GO:0051704) 2.652NECTIN1, SUMO1
single organism signaling (GO:0044700) 3.252BMP4, TP63
single organism reproductive process (GO:0044702) 2.732BMP4, TP63
BMP signaling pathway (GO:0030509) 5.332BMP4, MSX1
protein metabolic process (GO:0019538) 1.452BMP4, SUMO1
positive regulation of organelle organization (GO:0010638) 3.382TP63, MSX1
regulation of nuclear division (GO:0051783) 4.672BMP4, MSX1
positive regulation of ion transmembrane transporter activity (GO:0032414) 5.552BMP4, SUMO1
positive regulation of transporter activity (GO:0032411) 5.442BMP4, SUMO1
regulation of ion transmembrane transporter activity (GO:0032412) 4.552BMP4, SUMO1
regulation of anatomical structure morphogenesis (GO:0022603) 2.792BMP4, MSX1
regulation of DNA binding (GO:0051101) 5.212MSX1, SUMO1
negative regulation of binding (GO:0051100) 4.852MSX1, SUMO1
protein stabilization (GO:0050821) 4.862MSX1, SUMO1
positive regulation of cell differentiation (GO:0045597) 3.012BMP4, TP63
cellular protein metabolic process (GO:0044267) 1.632BMP4, SUMO1
regulation of mitotic cell cycle (GO:0007346) 3.712BMP4, TP63
cell morphogenesis involved in differentiation (GO:0000904) 4.672BMP4, MSX1
cell morphogenesis (GO:0000902) 4.352BMP4, MSX1
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090100) 5.122BMP4, MSX1
regulation of immune system process (GO:0002682) 2.52BMP4, SUMO1
positive regulation of catalytic activity (GO:0043085) 2.42BMP4, SUMO1
transcription from RNA polymerase II promoter (GO:0006366) 3.382TP63, MSX1
positive regulation of calcium ion transmembrane transport (GO:1904427) 5.692BMP4, SUMO1
cellular response to abiotic stimulus (GO:0071214) 4.152BMP4, TP63
organ formation (GO:0048645) 6.732BMP4, TP63
anatomical structure formation involved in morphogenesis (GO:0048646) 3.012BMP4, TP63
regulation of establishment of protein localization (GO:0070201) 3.022BMP4, TP63
macromolecule modification (GO:0043412) 1.732BMP4, SUMO1
protein modification process (GO:0036211) 1.792BMP4, SUMO1
negative regulation of DNA binding (GO:0043392) 5.92MSX1, SUMO1
heart development (GO:0007507) 4.242BMP4, MSX1
positive regulation of intracellular signal transduction (GO:1902533) 2.952BMP4, MSX1
regulation of ossification (GO:0030278) 4.532BMP4, TP63
regulation of hydrolase activity (GO:0051336) 2.532TP63, SUMO1
embryonic digit morphogenesis (GO:0042733) 5.692BMP4, MSX1
anterior/posterior pattern specification (GO:0009952) 4.712BMP4, MSX1
regulation of transmembrane transporter activity (GO:0022898) 4.522BMP4, SUMO1
regulation of cellular response to stress (GO:0080135) 3.42TP63, MSX1
regulation of nervous system development (GO:0051960) 3.12NECTIN1, BMP4
regulation of cation channel activity (GO:2001257) 5.272BMP4, SUMO1
cloacal septation (GO:0060197) 8.632BMP4, TP63
regulation of cellular protein localization (GO:1903827) 3.432BMP4, TP63
signaling (GO:0023052) 3.252BMP4, TP63
retina development in camera-type eye (GO:0060041) 5.512NECTIN1, BMP4
positive regulation of establishment of protein localization (GO:1904951) 3.492BMP4, TP63
positive regulation of cellular protein localization (GO:1903829) 3.852BMP4, TP63
keratinocyte proliferation (GO:0043616) 7.242IRF6, TP63
regulation of cellular response to growth factor stimulus (GO:0090287) 4.292BMP4, MSX1
regulation of odontogenesis (GO:0042481) 6.552BMP4, MSX1
positive regulation of multicellular organismal process (GO:0051240) 2.492BMP4, TP63
negative regulation of multicellular organismal process (GO:0051241) 2.842BMP4, TP63
positive regulation of protein metabolic process (GO:0051247) 2.432BMP4, SUMO1
regulation of transporter activity (GO:0032409) 4.452BMP4, SUMO1
positive regulation of cellular protein metabolic process (GO:0032270) 2.492BMP4, SUMO1
positive regulation of cell proliferation (GO:0008284) 3.012BMP4, TP63
reproductive structure development (GO:0048608) 4.082BMP4, TP63
response to abiotic stimulus (GO:0009628) 2.82BMP4, TP63
epithelium development (GO:0060429) 4.572BMP4, MSX1
positive regulation of ion transport (GO:0043270) 4.362BMP4, SUMO1
regulation of striated muscle cell differentiation (GO:0051153) 5.262BMP4, MSX1
prostate gland epithelium morphogenesis (GO:0060740) 6.732BMP4, TP63
hindlimb morphogenesis (GO:0035137) 6.122BMP4, MSX1
regulation of calcium ion transmembrane transport (GO:1903169) 4.982BMP4, SUMO1
regulation of cellular protein metabolic process (GO:0032268) 1.992BMP4, SUMO1
regulation of epithelial cell proliferation (GO:0050678) 4.062BMP4, TP63
positive regulation of epithelial cell proliferation (GO:0050679) 4.672BMP4, TP63
positive regulation of cation transmembrane transport (GO:1904064) 5.172BMP4, SUMO1
positive regulation of calcium ion transport (GO:0051928) 5.062BMP4, SUMO1
regulation of cation transmembrane transport (GO:1904062) 4.42BMP4, SUMO1
system development (GO:0048731) 2.922BMP4, TP63
gland development (GO:0048732) 4.152BMP4, TP63
regulation of protein stability (GO:0031647) 4.332MSX1, SUMO1
negative regulation of growth (GO:0045926) 4.242BMP4, MSX1
regulation of cellular localization (GO:0060341) 3.032BMP4, TP63
palate development (GO:0060021) 5.382MSX1, SUMO1
negative regulation of cell cycle process (GO:0010948) 4.372BMP4, TP63
cell cycle process (GO:0022402) 2.752IRF6, TP63
regulation of muscle cell differentiation (GO:0051147) 4.682BMP4, MSX1
negative regulation of muscle cell differentiation (GO:0051148) 5.72BMP4, MSX1
tube morphogenesis (GO:0035239) 4.352BMP4, TP63
regulation of ion transport (GO:0043269) 3.42BMP4, SUMO1
morphogenesis of an epithelium (GO:0002009) 4.082BMP4, TP63
regulation of growth (GO:0040008) 3.262BMP4, MSX1
regulation of epidermis development (GO:0045682) 5.572BMP4, TP63
cellular component morphogenesis (GO:0032989) 3.52BMP4, MSX1
regulation of mesenchymal cell proliferation (GO:0010464) 6.172BMP4, TP63
positive regulation of calcium ion transmembrane transporter activity (GO:1901021) 6.362BMP4, SUMO1
mesenchymal cell proliferation (GO:0010463) 7.162BMP4, MSX1
regulation of epidermal cell differentiation (GO:0045604) 5.922BMP4, TP63
sensory organ morphogenesis (GO:0090596) 5.722NECTIN1, BMP4
negative regulation of mitotic cell cycle (GO:0045930) 4.452BMP4, TP63
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092) 4.392BMP4, MSX1
positive regulation of cell cycle process (GO:0090068) 4.252MSX1, TP63
eye morphogenesis (GO:0048592) 5.92NECTIN1, BMP4
camera-type eye morphogenesis (GO:0048593) 6.782NECTIN1, BMP4
smooth muscle tissue development (GO:0048745) 7.022BMP4, TP63
cellular protein modification process (GO:0006464) 1.792BMP4, SUMO1
regulation of metal ion transport (GO:0010959) 3.942BMP4, SUMO1
reproductive process (GO:0022414) 2.552BMP4, TP63
embryonic hindlimb morphogenesis (GO:0035116) 6.362BMP4, MSX1
multi-organism cellular process (GO:0044764) 3.142NECTIN1, SUMO1
cell-cell signaling (GO:0007267) 3.352BMP4, TP63
cell communication (GO:0007154) 3.042BMP4, TP63
organelle organization (GO:0006996) 2.022TP63, SUMO1
cellular response to DNA damage stimulus (GO:0006974) 3.172TP63, SUMO1
regulation of cellular component movement (GO:0051270) 3.082BMP4, SUMO1
positive regulation of ossification (GO:0045778) 5.272BMP4, TP63
epidermal cell differentiation (GO:0009913) 5.132IRF6, TP63
regulation of calcium ion transport (GO:0051924) 4.382BMP4, SUMO1
regulation of cellular component biogenesis (GO:0044087) 3.082NECTIN1, SUMO1
forebrain development (GO:0030900) 5.482BMP4, MSX1
regulation of organ morphogenesis (GO:2000027) 4.222BMP4, MSX1
viral process (GO:0016032) 3.152NECTIN1, SUMO1
muscle tissue development (GO:0060537) 5.12BMP4, TP63
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.152NECTIN1, SUMO1

NET-GE enrichment

Term New enriched termICP valueGenes
protein localization to nucleus (GO:0034504) -4.90.002BMP4, MSX1, SUMO1
positive regulation of apoptotic signaling pathway (GO:2001235) -4.580.007MSX1, BMP4, TP63, SUMO1
limb morphogenesis (GO:0035108) -5.050.002MSX1, BMP4, TP63, SUMO1
cloacal septation (GO:0060197) -8.630.0BMP4, TP63
embryonic limb morphogenesis (GO:0030326) -5.240.002MSX1, BMP4, TP63
regulation of apoptotic signaling pathway (GO:2001233) -3.830.014TP63, BMP4, MSX1, SUMO1, IRF6
regulation of binding (GO:0051098) -4.080.028BMP4, MSX1, SUMO1
appendage morphogenesis (GO:0035107) -5.050.002BMP4, MSX1, SUMO1, TP63
negative regulation of epithelial cell proliferation (GO:0050680) NEW4.980.005BMP4, MSX1, SUMO1, TP63
palate development (GO:0060021) -5.380.001BMP4, MSX1, SUMO1, TP63
skeletal system development (GO:0001501) -4.490.036MSX1, BMP4, TP63, SUMO1
negative regulation of cell cycle process (GO:0010948) -4.370.049MSX1, BMP4, TP63, SUMO1
neuron migration (GO:0001764) NEW5.00.019BMP4, TP63, SUMO1, IRF6
retina development in camera-type eye (GO:0060041) -5.510.047BMP4, SUMO1, PVRL1
axon guidance (GO:0007411) NEW4.440.015MSX1, BMP4, SUMO1, PVRL1, IRF6
pituitary gland development (GO:0021983) NEW6.330.027BMP4, MSX1
developmental growth (GO:0048589) NEW4.050.001TP63, BMP4, MSX1, SUMO1, IRF6
regulation of cell division (GO:0051302) NEW4.880.037BMP4, MSX1, TP63
keratinocyte proliferation (GO:0043616) -7.240.0IRF6, BMP4, TP63
growth (GO:0040007) NEW3.80.025MSX1, BMP4, TP63, SUMO1, IRF6
positive regulation of intrinsic apoptotic signaling pathway (GO:2001244) NEW5.760.011BMP4, MSX1, SUMO1
regulation of odontogenesis (GO:0042481) -6.550.027BMP4, MSX1
regulation of cell projection organization (GO:0031344) NEW3.380.042TP63, BMP4, MSX1, SUMO1, IRF6
mesenchymal cell proliferation (GO:0010463) -7.160.034BMP4, MSX1
transcription from RNA polymerase II promoter (GO:0006366) -3.380.031MSX1, BMP4, TP63, SUMO1, IRF6
regulation of signal transduction by p53 class mediator (GO:1901796) -4.630.004MSX1, SUMO1, TP63
cell surface receptor signaling pathway involved in heart development (GO:0061311) NEW6.960.016BMP4, MSX1
developmental growth involved in morphogenesis (GO:0060560) NEW5.150.001BMP4, MSX1, SUMO1, TP63
forebrain anterior/posterior pattern specification (GO:0021797) NEW7.940.017MSX1, SUMO1
organ formation (GO:0048645) -6.730.012BMP4, TP63
central nervous system neuron differentiation (GO:0021953) NEW5.170.004BMP4, MSX1, SUMO1, TP63
columnar/cuboidal epithelial cell differentiation (GO:0002065) NEW5.840.029BMP4, TP63, SUMO1
keratinocyte differentiation (GO:0030216) -5.370.0BMP4, TP63, SUMO1, IRF6
cell proliferation (GO:0008283) -3.230.017IRF6, BMP4, MSX1, TP63
positive regulation of proteolysis involved in cellular protein catabolic process (GO:1903052) NEW4.60.005BMP4, TP63, SUMO1
BMP signaling pathway involved in heart development (GO:0061312) NEW9.040.001BMP4, MSX1
smooth muscle tissue development (GO:0048745) -7.020.008BMP4, TP63
tissue development (GO:0009888) -3.270.017BMP4, SUMO1, IRF6, MSX1, TP63, PVRL1
regulation of behavior (GO:0050795) NEW5.550.041BMP4, TP63, SUMO1, IRF6
negative regulation of binding (GO:0051100) -4.850.002BMP4, MSX1, SUMO1, IRF6
embryonic hindlimb morphogenesis (GO:0035116) -6.360.034BMP4, MSX1
prostate gland epithelium morphogenesis (GO:0060740) -6.730.023BMP4, TP63
forelimb morphogenesis (GO:0035136) NEW6.040.006BMP4, MSX1, SUMO1
regionalization (GO:0003002) -4.240.041MSX1, BMP4, TP63
embryonic appendage morphogenesis (GO:0035113) -5.240.002BMP4, MSX1, TP63
neuron projection guidance (GO:0097485) NEW4.430.015BMP4, PVRL1, MSX1, SUMO1, IRF6
positive regulation of BMP signaling pathway (GO:0030513) -6.260.029BMP4, MSX1
regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213) NEW7.430.006BMP4, MSX1
locomotion (GO:0040011) NEW2.910.032BMP4, SUMO1, IRF6, MSX1, TP63, PVRL1
odontogenesis of dentin-containing tooth (GO:0042475) -5.520.001BMP4, MSX1, SUMO1, TP63
negative regulation of mesoderm development (GO:2000381) NEW7.780.002BMP4, TP63
odontogenesis (GO:0042476) -5.190.002MSX1, BMP4, TP63, SUMO1
anatomical structure development (GO:0048856) -1.580.008BMP4, SUMO1, IRF6, MSX1, TP63, PVRL1
regulation of DNA replication (GO:0006275) NEW5.020.004BMP4, MSX1, SUMO1, TP63
epithelial cell proliferation (GO:0050673) -5.210.001BMP4, TP63, SUMO1, IRF6
regulation of nervous system development (GO:0051960) -3.10.007BMP4, SUMO1, IRF6, MSX1, TP63, PVRL1
regulation of organ morphogenesis (GO:2000027) -4.220.021BMP4, MSX1, SUMO1, TP63
protein localization to organelle (GO:0033365) -3.570.005BMP4, MSX1, SUMO1
regulation of intrinsic apoptotic signaling pathway (GO:2001242) NEW4.740.006MSX1, BMP4, TP63, SUMO1
mammary gland epithelium development (GO:0061180) NEW7.430.023BMP4, MSX1
hindlimb morphogenesis (GO:0035137) -6.120.01BMP4, MSX1, SUMO1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.286BMP4, SUMO1, IRF6, NECTIN1, MSX1, TP63
cell part (GO:0044464) 0.116BMP4, SUMO1, IRF6, NECTIN1, MSX1, TP63
membrane-bounded organelle (GO:0043227) 0.476BMP4, SUMO1, IRF6, NECTIN1, MSX1, TP63
organelle (GO:0043226) 0.46BMP4, SUMO1, IRF6, NECTIN1, MSX1, TP63
cytoplasm (GO:0005737) 1.015TP63, BMP4, MSX1, SUMO1, IRF6
intracellular organelle (GO:0043229) 0.515IRF6, NECTIN1, MSX1, SUMO1, TP63
intracellular membrane-bounded organelle (GO:0043231) 0.65MSX1, IRF6, NECTIN1, TP63, SUMO1
nucleus (GO:0005634) 1.074IRF6, MSX1, SUMO1, TP63
protein complex (GO:0043234) 1.513NECTIN1, TP63, SUMO1
nucleoplasm (GO:0005654) 1.893MSX1, TP63, SUMO1
macromolecular complex (GO:0032991) 1.353NECTIN1, TP63, SUMO1
intracellular organelle part (GO:0044446) 0.813MSX1, SUMO1, TP63
neuron part (GO:0097458) 2.643NECTIN1, TP63, SUMO1
nuclear part (GO:0044428) 1.553MSX1, TP63, SUMO1
neuron projection (GO:0043005) 3.123NECTIN1, TP63, SUMO1
cell projection (GO:0042995) 2.473NECTIN1, TP63, SUMO1
organelle part (GO:0044422) 0.793MSX1, TP63, SUMO1
vesicle (GO:0031982) 1.642IRF6, BMP4
cytosol (GO:0005829) 1.682IRF6, TP63
membrane (GO:0016020) 0.682NECTIN1, SUMO1
dendrite (GO:0030425) 3.922TP63, SUMO1
membrane-bounded vesicle (GO:0031988) 1.712IRF6, BMP4
plasma membrane protein complex (GO:0098797) 3.552NECTIN1, SUMO1
membrane protein complex (GO:0098796) 2.842NECTIN1, SUMO1
cytoplasmic part (GO:0044444) 0.822IRF6, TP63
extracellular region (GO:0005576) 2.182NECTIN1, BMP4
chromatin (GO:0000785) 3.992TP63, SUMO1
synapse (GO:0045202) 3.582NECTIN1, SUMO1
plasma membrane (GO:0005886) 1.392NECTIN1, SUMO1
membrane part (GO:0044425) 0.952NECTIN1, SUMO1
chromosomal part (GO:0044427) 3.182TP63, SUMO1
plasma membrane part (GO:0044459) 1.952NECTIN1, SUMO1
extracellular region part (GO:0044421) 1.572IRF6, BMP4

NET-GE enrichment

Term New enriched termICP valueGenes
anchoring junction (GO:0070161) NEW3.610.043BMP4, PVRL1, SUMO1, TP63
transcription factor complex (GO:0005667) NEW4.10.011BMP4, MSX1, SUMO1, TP63
nuclear chromosome part (GO:0044454) NEW3.670.011IRF6, MSX1, SUMO1, TP63
organelle lumen (GO:0043233) NEW3.050.015MSX1, BMP4, TP63, SUMO1, IRF6
membrane-enclosed lumen (GO:0031974) NEW3.050.022MSX1, BMP4, TP63, SUMO1, IRF6
extracellular matrix (GO:0031012) NEW3.810.014BMP4, TP63, SUMO1, IRF6
intracellular organelle lumen (GO:0070013) NEW3.050.01MSX1, BMP4, TP63, SUMO1, IRF6
nuclear chromatin (GO:0000790) NEW4.420.001IRF6, MSX1, SUMO1, TP63
extracellular region (GO:0005576) -2.180.014BMP4, SUMO1, IRF6, MSX1, TP63, PVRL1
chromatin (GO:0000785) -3.990.0TP63, BMP4, MSX1, SUMO1, IRF6
neuron projection (GO:0043005) -3.120.033PVRL1, SUMO1, TP63
chromosomal part (GO:0044427) -3.180.005MSX1, BMP4, TP63, SUMO1, IRF6