Disease table of SEVERE CUTANEOUS ADVERSE REACTION, SUSCEPTIBILITY TO OMIM ID: 608579

Gene-disease associations table

GeneAssociated with SEVERE CUTANEOUS ADVERSE REACTION, SUSCEPTIBILITY TO inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
HLA-BOMIMHGNC link6p21.332608579, PS106300
HLA-AOMIMHGNC link6p22.11608579

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Common tandem groupNumber of genes in this tandem group associated to this diseaseGenes in this tandem group associated to this disease
Group 2812HLA-A, HLA-B
Cytogenetic band analysis
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
6p22HLA-A, HLA-B
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
6p2HLA-A, HLA-B
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
62HLA-A, HLA-B
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
MYCNNO44MCM8, MCM7, HDAC2, TP53, BIRC5, IFNG, HLA-F, MCM3, LRRN3, BMI1, SKP2, MDM2, ABCB1, MCM2, DDB1, NES, CD44, HLA-C, HLA-G, CDKN1A, TP53INP1, HLA-B, NGFR, HLA-A, CIITA, MCM6, CTSD, ABCC1, LXN, DKK3, BAX, CDK6, HLA-E, NDRG1, TH, EFNB3, ID2, MCM5, MCM10, MYCL, TERT, NTRK1, MCM4, CDKN1B2HLA-B, HLA-A
CIITANO30IRF2, HDAC2, COL1A2, HLA-DRB4, HLA-DRB1, HLA-DRB3, HLA-DRA, IL4, HLA-DMA, HLA-C, SIRT1, HLA-DQB1, HLA-B, SLC26A3, HLA-A, PLXNA1, COL1A1, HLA-DMB, HLA-DRB5, S100A4, MMP9, IRF1, PSMC5, HLA-DOB, HLA-DOA, HLA-DPB1, HLA-G, RAB4B, CREBBP, FASLG2HLA-B, HLA-A
MYCNO102CBFB, PRDX3, CHKA, ATF3, CDK4, PCNA, CEBPA, LDHA, DKK1, MTDH, TFAP4, HLA-G, CDC25A, UBE2C, HLA-B, GATA1, TP53, BAG2, PMAIP1, CDK6, WRN, PGK1, TFAM, IGK, JUNB, ZFP36, HNRNPA1, MYB, SART3, EBNA1BP2, TOP1MT, ST3GAL4, CD33, CCND2, PTBP1, CDCA7, RB1, CCNA2, HLA-C, CYP3A4, FMR1, TERT, NFE2, MME, NDRG1, HDAC2, BRD7, FASLG, CCNB1, TP73, RCC1, SFRP1, HLA-F, CFLAR, BCAT1, CD38, TFRC, CCND1, MTA1, KRAS, HNRNPA2B1, CDC34, ST3GAL3, HLA-A, FUT3, NOL7, FTH1P18, VEGFA, EP300, CDK2, ASS1, SURF1, CDC25C, IER3, ST3GAL1, FOXM1, HSPA4, XPO1, CAD, SHMT1, DDX18, IGF2BP1, BMI1, IPO7, BCL2, CXCR4, SRSF1, TLX1, PRODH, NBN, CDKN1A, IFNA1, TNFRSF10B, ID2, CCNE1, SURF2, HLA-E, CREBBP, MAPK1, IL6, EIF4E, ODC12HLA-B, HLA-A
HIVEP2NO6HLA-E, HLA-B, HLA-A, HLA-F, HLA-C, HLA-G2HLA-B, HLA-A
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
HLA-BYES4CIITA, MYC, HIVEP2, MYCN0
HLA-AYES6IRF1, HIVEP2, RELA, CIITA, MYC, MYCN0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
HLA-BHLA-AYes12TAP2, VCP, HLA-E, HLA-B, LILRB1, TAP1, B2M, ERBB3, CD8A, HLA-C, ENV, MMS19

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
HLA-BHLA-ANo2B2M, TRAC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
HLA-AHLA-Byes, complexThey form a heterodimer of an alpha chain and a beta chain. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Antigen processing and presentationhsa046126.042HLA-B, HLA-A
Herpes simplex infectionhsa051685.082HLA-B, HLA-A
Natural killer cell mediated cytotoxicityhsa046505.532HLA-B, HLA-A
Autoimmune thyroid diseasehsa053206.622HLA-B, HLA-A
Allograft rejectionhsa053306.912HLA-B, HLA-A
Viral carcinogenesishsa052035.082HLA-B, HLA-A
Graft-versus-host diseasehsa053326.842HLA-B, HLA-A
Cell adhesion molecules (CAMs)hsa045145.362HLA-B, HLA-A
Phagosomehsa041455.272HLA-B, HLA-A
Endocytosishsa041444.922HLA-B, HLA-A
Type I diabetes mellitushsa049406.792HLA-B, HLA-A
HTLV-I infectionhsa051664.592HLA-B, HLA-A
Viral myocarditishsa054166.452HLA-B, HLA-A
Epstein-Barr virus infectionhsa051694.972HLA-B, HLA-A

NET-GE enrichment

Term New enriched termICP valueGenes
Antigen processing and presentation (hsa04612) -6.040.0HLA-B, HLA-A
Natural killer cell mediated cytotoxicity (hsa04650) -5.530.0HLA-B, HLA-A
Allograft rejection (hsa05330) -6.910.0HLA-B, HLA-A
Graft-versus-host disease (hsa05332) -6.840.0HLA-B, HLA-A
Cell adhesion molecules (CAMs) (hsa04514) -5.360.0HLA-B, HLA-A
Phagosome (hsa04145) -5.270.0HLA-B, HLA-A
Endocytosis (hsa04144) -4.920.0HLA-B, HLA-A
Immune systemNEW2.920.004HLA-B, HLA-A
Type I diabetes mellitus (hsa04940) -6.790.0HLA-B, HLA-A
Viral myocarditis (hsa05416) -6.450.0HLA-B, HLA-A
Herpes simplex infection (hsa05168) -5.080.0HLA-B, HLA-A
Epstein-Barr virus infection (hsa05169) -4.970.0HLA-B, HLA-A
HTLV-I infection (hsa05166) -4.590.0HLA-B, HLA-A
Infectious diseases: ViralNEW3.290.044HLA-B, HLA-A
Immune diseasesNEW4.470.0HLA-B, HLA-A
Cancers: OverviewNEW2.720.002HLA-B, HLA-A
Endocrine and metabolic diseasesNEW4.750.0HLA-B, HLA-A
Cardiovascular diseasesNEW5.060.0HLA-B, HLA-A
Autoimmune thyroid disease (hsa05320) -6.620.0HLA-B, HLA-A
Viral carcinogenesis (hsa05203) -5.080.0HLA-B, HLA-A
Signaling molecules and interactionNEW3.090.034HLA-B, HLA-A
Transport and catabolismNEW3.490.0HLA-B, HLA-A
Cellular ProcessesNEW2.220.012HLA-B, HLA-A
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Antigen processing-Cross presentationR-HSA-12369755.882HLA-B, HLA-A
Immune SystemR-HSA-1682562.372HLA-B, HLA-A
ER-Phagosome pathwayR-HSA-12369746.082HLA-B, HLA-A
Endosomal/Vacuolar pathwayR-HSA-12369776.922HLA-B, HLA-A
Cytokine Signaling in Immune systemR-HSA-12802153.742HLA-B, HLA-A
Interferon SignalingR-HSA-9135314.952HLA-B, HLA-A
Class I MHC mediated antigen processing & presentationR-HSA-9831694.652HLA-B, HLA-A
Interferon gamma signalingR-HSA-8773005.672HLA-B, HLA-A
Interferon alpha/beta signalingR-HSA-9097336.042HLA-B, HLA-A
Antigen Presentation: Folding, assembly and peptide loading of class I MHCR-HSA-9831706.642HLA-B, HLA-A
Adaptive Immune SystemR-HSA-12802183.192HLA-B, HLA-A
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellR-HSA-1989334.72HLA-B, HLA-A

NET-GE enrichment

Term New enriched termICP valueGenes
Antigen processing-Cross presentation (R-HSA-1236975) -5.880.0HLA-B, HLA-A
Immune System (R-HSA-168256) -2.370.0HLA-B, HLA-A
ER-Phagosome pathway (R-HSA-1236974) -6.080.0HLA-B, HLA-A
Endosomal/Vacuolar pathway (R-HSA-1236977) -6.920.0HLA-B, HLA-A
Cytokine Signaling in Immune system (R-HSA-1280215) -3.740.0HLA-B, HLA-A
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (R-HSA-983170) -6.640.0HLA-B, HLA-A
Class I MHC mediated antigen processing & presentation (R-HSA-983169) -4.650.0HLA-B, HLA-A
Interferon gamma signaling (R-HSA-877300) -5.670.0HLA-B, HLA-A
Interferon alpha/beta signaling (R-HSA-909733) -6.040.0HLA-B, HLA-A
Interferon Signaling (R-HSA-913531) -4.950.0HLA-B, HLA-A
Adaptive Immune System (R-HSA-1280218) -3.190.0HLA-B, HLA-A
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (R-HSA-198933) -4.70.0HLA-B, HLA-A
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
peptide binding (GO:0042277) 4.222HLA-B, HLA-A
antigen binding (GO:0003823) 5.022HLA-B, HLA-A
peptide antigen binding (GO:0042605) 6.182HLA-B, HLA-A
amide binding (GO:0033218) 4.142HLA-B, HLA-A
binding (GO:0005488) 0.182HLA-B, HLA-A
protein binding (GO:0005515) 0.462HLA-B, HLA-A
TAP binding (GO:0046977) 7.792HLA-B, HLA-A
receptor binding (GO:0005102) 2.432HLA-B, HLA-A

NET-GE enrichment

Term New enriched termICP valueGenes
peptide antigen binding (GO:0042605) -6.180.0HLA-B, HLA-A
amide binding (GO:0033218) -4.140.0HLA-B, HLA-A
binding (GO:0005488) -0.180.0HLA-B, HLA-A
antigen binding (GO:0003823) -5.020.0HLA-B, HLA-A
TAP binding (GO:0046977) -7.790.0HLA-B, HLA-A
peptide binding (GO:0042277) -4.220.0HLA-B, HLA-A
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
detection of biotic stimulus (GO:0009595) 6.552HLA-B, HLA-A
cytokine-mediated signaling pathway (GO:0019221) 3.62HLA-B, HLA-A
negative regulation of response to stimulus (GO:0048585) 2.522HLA-B, HLA-A
positive regulation of response to stimulus (GO:0048584) 2.182HLA-B, HLA-A
regulation of response to stimulus (GO:0048583) 1.542HLA-B, HLA-A
negative regulation of lymphocyte mediated immunity (GO:0002707) 6.152HLA-B, HLA-A
negative regulation of defense response (GO:0031348) 4.752HLA-B, HLA-A
positive regulation of leukocyte mediated immunity (GO:0002705) 5.322HLA-B, HLA-A
negative regulation of leukocyte mediated immunity (GO:0002704) 5.882HLA-B, HLA-A
regulation of leukocyte mediated immunity (GO:0002703) 4.72HLA-B, HLA-A
signal transduction (GO:0007165) 1.282HLA-B, HLA-A
cell surface receptor signaling pathway (GO:0007166) 2.092HLA-B, HLA-A
regulation of cell killing (GO:0031341) 5.62HLA-B, HLA-A
positive regulation of cell killing (GO:0031343) 6.092HLA-B, HLA-A
negative regulation of cell killing (GO:0031342) 6.842HLA-B, HLA-A
regulation of T cell mediated immunity (GO:0002709) 5.762HLA-B, HLA-A
positive regulation of lymphocyte mediated immunity (GO:0002708) 5.492HLA-B, HLA-A
response to external biotic stimulus (GO:0043207) 3.132HLA-B, HLA-A
response to bacterium (GO:0009617) 4.182HLA-B, HLA-A
interspecies interaction between organisms (GO:0044419) 3.082HLA-B, HLA-A
positive regulation of biological process (GO:0048518) 1.22HLA-B, HLA-A
biological regulation (GO:0065007) 0.392HLA-B, HLA-A
negative regulation of immune system process (GO:0002683) 3.852HLA-B, HLA-A
detection of external biotic stimulus (GO:0098581) 6.682HLA-B, HLA-A
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002824) 5.482HLA-B, HLA-A
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002822) 4.992HLA-B, HLA-A
positive regulation of adaptive immune response (GO:0002821) 5.422HLA-B, HLA-A
response to other organism (GO:0051707) 3.482HLA-B, HLA-A
multi-organism process (GO:0051704) 2.652HLA-B, HLA-A
response to biotic stimulus (GO:0009607) 3.092HLA-B, HLA-A
response to external stimulus (GO:0009605) 2.552HLA-B, HLA-A
regulation of lymphocyte mediated immunity (GO:0002706) 4.992HLA-B, HLA-A
immune system process (GO:0002376) 2.292HLA-B, HLA-A
positive regulation of leukocyte mediated cytotoxicity (GO:0001912) 6.232HLA-B, HLA-A
negative regulation of leukocyte mediated cytotoxicity (GO:0001911) 6.962HLA-B, HLA-A
regulation of leukocyte mediated cytotoxicity (GO:0001910) 5.782HLA-B, HLA-A
positive regulation of T cell mediated cytotoxicity (GO:0001916) 6.962HLA-B, HLA-A
regulation of T cell mediated cytotoxicity (GO:0001914) 6.592HLA-B, HLA-A
antigen processing and presentation of peptide antigen (GO:0048002) 4.562HLA-B, HLA-A
regulation of biological process (GO:0050789) 0.452HLA-B, HLA-A
detection of bacterium (GO:0016045) 7.332HLA-B, HLA-A
positive regulation of immune system process (GO:0002684) 2.962HLA-B, HLA-A
negative regulation of innate immune response (GO:0045824) 6.122HLA-B, HLA-A
regulation of immune system process (GO:0002682) 2.52HLA-B, HLA-A
regulation of defense response (GO:0031347) 3.112HLA-B, HLA-A
antigen processing and presentation (GO:0019882) 4.362HLA-B, HLA-A
antigen processing and presentation of endogenous antigen (GO:0019883) 6.842HLA-B, HLA-A
antigen processing and presentation of exogenous antigen (GO:0019884) 4.592HLA-B, HLA-A
antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) 7.092HLA-B, HLA-A
regulation of cellular process (GO:0050794) 0.52HLA-B, HLA-A
defense response (GO:0006952) 2.782HLA-B, HLA-A
response to stress (GO:0006950) 1.82HLA-B, HLA-A
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (GO:0002480) 7.532HLA-B, HLA-A
regulation of multicellular organismal process (GO:0051239) 1.872HLA-B, HLA-A
immune response (GO:0006955) 2.862HLA-B, HLA-A
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway (GO:0002484) 7.432HLA-B, HLA-A
detection of stimulus (GO:0051606) 3.222HLA-B, HLA-A
regulation of natural killer cell mediated cytotoxicity (GO:0042269) 6.232HLA-B, HLA-A
interferon-gamma-mediated signaling pathway (GO:0060333) 5.482HLA-B, HLA-A
regulation of response to stress (GO:0080134) 2.532HLA-B, HLA-A
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent (GO:0002486) 8.632HLA-B, HLA-A
regulation of immune effector process (GO:0002697) 3.712HLA-B, HLA-A
positive regulation of immune effector process (GO:0002699) 4.692HLA-B, HLA-A
negative regulation of immune effector process (GO:0002698) 5.12HLA-B, HLA-A
type I interferon signaling pathway (GO:0060337) 5.592HLA-B, HLA-A
antigen processing and presentation of endogenous peptide antigen (GO:0002483) 7.022HLA-B, HLA-A
regulation of adaptive immune response (GO:0002819) 4.912HLA-B, HLA-A
protection from natural killer cell mediated cytotoxicity (GO:0042270) 7.942HLA-B, HLA-A
cellular process (GO:0009987) 0.262HLA-B, HLA-A
detection of other organism (GO:0098543) 7.242HLA-B, HLA-A
negative regulation of biological process (GO:0048519) 1.332HLA-B, HLA-A
negative regulation of immune response (GO:0050777) 4.942HLA-B, HLA-A
regulation of immune response (GO:0050776) 2.982HLA-B, HLA-A
positive regulation of immune response (GO:0050778) 3.42HLA-B, HLA-A
regulation of cytokine production (GO:0001817) 3.42HLA-B, HLA-A
response to stimulus (GO:0050896) 1.222HLA-B, HLA-A
antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) 5.542HLA-B, HLA-A
antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) 5.192HLA-B, HLA-A
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:0002479) 5.592HLA-B, HLA-A
antigen processing and presentation of exogenous peptide antigen (GO:0002478) 4.632HLA-B, HLA-A
negative regulation of natural killer cell mediated cytotoxicity (GO:0045953) 7.242HLA-B, HLA-A
regulation of innate immune response (GO:0045088) 3.862HLA-B, HLA-A
positive regulation of T cell mediated immunity (GO:0002711) 6.232HLA-B, HLA-A
multi-organism cellular process (GO:0044764) 3.142HLA-B, HLA-A
regulation of natural killer cell mediated immunity (GO:0002715) 6.22HLA-B, HLA-A
negative regulation of natural killer cell mediated immunity (GO:0002716) 7.242HLA-B, HLA-A
viral process (GO:0016032) 3.152HLA-B, HLA-A
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.152HLA-B, HLA-A

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of immune system process (GO:0002682) -2.50.0HLA-B, HLA-A
cytokine-mediated signaling pathway (GO:0019221) -3.60.0HLA-B, HLA-A
negative regulation of leukocyte mediated cytotoxicity (GO:0001911) -6.960.027HLA-B, HLA-A
positive regulation of response to stimulus (GO:0048584) -2.180.0HLA-B, HLA-A
regulation of response to stimulus (GO:0048583) -1.540.0HLA-B, HLA-A
regulation of adaptive immune response (GO:0002819) -4.910.0HLA-B, HLA-A
regulation of lymphocyte mediated immunity (GO:0002706) -4.990.0HLA-B, HLA-A
antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) -5.540.0HLA-B, HLA-A
regulation of leukocyte mediated immunity (GO:0002703) -4.70.0HLA-B, HLA-A
signal transduction (GO:0007165) -1.280.0HLA-B, HLA-A
cellular response to chemical stimulus (GO:0070887) NEW2.570.0HLA-B, HLA-A
antigen processing and presentation of peptide antigen (GO:0048002) -4.560.0HLA-B, HLA-A
positive regulation of cell killing (GO:0031343) -6.090.0HLA-B, HLA-A
negative regulation of cell killing (GO:0031342) -6.840.027HLA-B, HLA-A
regulation of biological process (GO:0050789) -0.450.0HLA-B, HLA-A
regulation of T cell mediated immunity (GO:0002709) -5.760.0HLA-B, HLA-A
response to cytokine (GO:0034097) NEW3.840.0HLA-B, HLA-A
antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) -5.190.0HLA-B, HLA-A
positive regulation of leukocyte mediated immunity (GO:0002705) -5.320.0HLA-B, HLA-A
protection from natural killer cell mediated cytotoxicity (GO:0042270) -7.940.003HLA-B, HLA-A
regulation of cell killing (GO:0031341) -5.60.0HLA-B, HLA-A
cellular response to type I interferon (GO:0071357) NEW9.730.0HLA-B, HLA-A
cell surface receptor signaling pathway (GO:0007166) -2.090.0HLA-B, HLA-A
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:0002479) -5.590.0HLA-B, HLA-A
antigen processing and presentation of exogenous peptide antigen (GO:0002478) -4.630.0HLA-B, HLA-A
cellular response to organic substance (GO:0071310) NEW2.780.0HLA-B, HLA-A
interspecies interaction between organisms (GO:0044419) -3.080.0HLA-B, HLA-A
positive regulation of immune system process (GO:0002684) -2.960.0HLA-B, HLA-A
negative regulation of natural killer cell mediated cytotoxicity (GO:0045953) -7.240.011HLA-B, HLA-A
positive regulation of biological process (GO:0048518) -1.20.0HLA-B, HLA-A
biological regulation (GO:0065007) -0.390.0HLA-B, HLA-A
positive regulation of lymphocyte mediated immunity (GO:0002708) -5.490.0HLA-B, HLA-A
antigen processing and presentation (GO:0019882) -4.360.0HLA-B, HLA-A
antigen processing and presentation of endogenous antigen (GO:0019883) -6.840.005HLA-B, HLA-A
antigen processing and presentation of exogenous antigen (GO:0019884) -4.590.0HLA-B, HLA-A
antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) -7.090.001HLA-B, HLA-A
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002824) -5.480.0HLA-B, HLA-A
cellular process (GO:0009987) -0.260.005HLA-B, HLA-A
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002822) -4.990.0HLA-B, HLA-A
cellular response to stimulus (GO:0051716) NEW1.970.0HLA-B, HLA-A
response to type I interferon (GO:0034340) NEW7.650.0HLA-B, HLA-A
positive regulation of adaptive immune response (GO:0002821) -5.420.0HLA-B, HLA-A
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway (GO:0002484) -7.430.0HLA-B, HLA-A
interferon-gamma-mediated signaling pathway (GO:0060333) -5.480.0HLA-B, HLA-A
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent (GO:0002486) -8.630.0HLA-B, HLA-A
multi-organism cellular process (GO:0044764) -3.140.0HLA-B, HLA-A
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (GO:0002480) -7.530.0HLA-B, HLA-A
type I interferon signaling pathway (GO:0060337) -5.590.0HLA-B, HLA-A
negative regulation of natural killer cell mediated immunity (GO:0002716) -7.240.011HLA-B, HLA-A
antigen processing and presentation of endogenous peptide antigen (GO:0002483) -7.020.0HLA-B, HLA-A
response to chemical (GO:0042221) NEW1.980.0HLA-B, HLA-A
response to interferon-gamma (GO:0034341) NEW5.40.0HLA-B, HLA-A
response to organic substance (GO:0010033) NEW2.20.0HLA-B, HLA-A
regulation of cellular process (GO:0050794) -0.50.0HLA-B, HLA-A
multi-organism process (GO:0051704) -2.650.0HLA-B, HLA-A
regulation of immune response (GO:0050776) -2.980.0HLA-B, HLA-A
positive regulation of T cell mediated immunity (GO:0002711) -6.230.0HLA-B, HLA-A
cellular response to cytokine stimulus (GO:0071345) NEW4.330.0HLA-B, HLA-A
response to stimulus (GO:0050896) -1.220.0HLA-B, HLA-A
cellular response to interferon-gamma (GO:0071346) NEW5.780.0HLA-B, HLA-A
positive regulation of immune response (GO:0050778) -3.40.0HLA-B, HLA-A
immune system process (GO:0002376) -2.290.0HLA-B, HLA-A
positive regulation of leukocyte mediated cytotoxicity (GO:0001912) -6.230.0HLA-B, HLA-A
regulation of immune effector process (GO:0002697) -3.710.0HLA-B, HLA-A
regulation of leukocyte mediated cytotoxicity (GO:0001910) -5.780.0HLA-B, HLA-A
positive regulation of T cell mediated cytotoxicity (GO:0001916) -6.960.0HLA-B, HLA-A
viral process (GO:0016032) -3.150.0HLA-B, HLA-A
regulation of T cell mediated cytotoxicity (GO:0001914) -6.590.0HLA-B, HLA-A
symbiosis, encompassing mutualism through parasitism (GO:0044403) -3.150.0HLA-B, HLA-A
positive regulation of immune effector process (GO:0002699) -4.690.0HLA-B, HLA-A
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
endoplasmic reticulum (GO:0005783) 2.562HLA-B, HLA-A
extracellular region part (GO:0044421) 1.572HLA-B, HLA-A
ER to Golgi transport vesicle membrane (GO:0012507) 5.812HLA-B, HLA-A
organelle (GO:0043226) 0.42HLA-B, HLA-A
intracellular organelle (GO:0043229) 0.512HLA-B, HLA-A
integral component of endoplasmic reticulum membrane (GO:0030176) 5.012HLA-B, HLA-A
macromolecular complex (GO:0032991) 1.352HLA-B, HLA-A
integral component of plasma membrane (GO:0005887) 2.572HLA-B, HLA-A
membrane-bounded vesicle (GO:0031988) 1.712HLA-B, HLA-A
membrane-bounded organelle (GO:0043227) 0.472HLA-B, HLA-A
intrinsic component of endoplasmic reticulum membrane (GO:0031227) 4.972HLA-B, HLA-A
intrinsic component of membrane (GO:0031224) 1.132HLA-B, HLA-A
endosome membrane (GO:0010008) 3.832HLA-B, HLA-A
plasma membrane protein complex (GO:0098797) 3.552HLA-B, HLA-A
endocytic vesicle membrane (GO:0030666) 4.822HLA-B, HLA-A
organelle membrane (GO:0031090) 1.972HLA-B, HLA-A
coated vesicle membrane (GO:0030662) 5.02HLA-B, HLA-A
intrinsic component of plasma membrane (GO:0031226) 2.532HLA-B, HLA-A
integral component of membrane (GO:0016021) 1.142HLA-B, HLA-A
membrane (GO:0016020) 0.682HLA-B, HLA-A
integral component of lumenal side of endoplasmic reticulum membrane (GO:0071556) 6.432HLA-B, HLA-A
vacuolar membrane (GO:0005774) 3.452HLA-B, HLA-A
cytoplasmic vesicle part (GO:0044433) 3.412HLA-B, HLA-A
endoplasmic reticulum part (GO:0044432) 2.732HLA-B, HLA-A
Golgi apparatus part (GO:0044431) 3.02HLA-B, HLA-A
vacuolar part (GO:0044437) 3.262HLA-B, HLA-A
plasma membrane part (GO:0044459) 1.952HLA-B, HLA-A
bounding membrane of organelle (GO:0098588) 2.392HLA-B, HLA-A
early endosome membrane (GO:0031901) 5.062HLA-B, HLA-A
Golgi apparatus (GO:0005794) 2.72HLA-B, HLA-A
cell surface (GO:0009986) 3.442HLA-B, HLA-A
transport vesicle membrane (GO:0030658) 4.862HLA-B, HLA-A
cytoplasmic vesicle membrane (GO:0030659) 3.672HLA-B, HLA-A
vesicle membrane (GO:0012506) 3.632HLA-B, HLA-A
plasma membrane (GO:0005886) 1.392HLA-B, HLA-A
protein complex (GO:0043234) 1.512HLA-B, HLA-A
extracellular vesicle (GO:1903561) 1.892HLA-B, HLA-A
vesicle (GO:0031982) 1.642HLA-B, HLA-A
MHC protein complex (GO:0042611) 6.432HLA-B, HLA-A
MHC class I protein complex (GO:0042612) 7.242HLA-B, HLA-A
extracellular organelle (GO:0043230) 1.892HLA-B, HLA-A
intracellular membrane-bounded organelle (GO:0043231) 0.62HLA-B, HLA-A
phagocytic vesicle membrane (GO:0030670) 5.712HLA-B, HLA-A
extracellular exosome (GO:0070062) 1.892HLA-B, HLA-A
cell part (GO:0044464) 0.112HLA-B, HLA-A
Golgi membrane (GO:0000139) 3.282HLA-B, HLA-A
intracellular organelle part (GO:0044446) 0.812HLA-B, HLA-A
membrane protein complex (GO:0098796) 2.842HLA-B, HLA-A
cytoplasmic part (GO:0044444) 0.822HLA-B, HLA-A
endosomal part (GO:0044440) 3.732HLA-B, HLA-A
intracellular part (GO:0044424) 0.282HLA-B, HLA-A
membrane part (GO:0044425) 0.952HLA-B, HLA-A
whole membrane (GO:0098805) 2.852HLA-B, HLA-A
organelle part (GO:0044422) 0.792HLA-B, HLA-A

NET-GE enrichment

Term New enriched termICP valueGenes
endoplasmic reticulum (GO:0005783) -2.560.0HLA-B, HLA-A
plasma membrane (GO:0005886) -1.390.0HLA-B, HLA-A
intracellular organelle (GO:0043229) -0.510.0HLA-B, HLA-A
integral component of endoplasmic reticulum membrane (GO:0030176) -5.010.0HLA-B, HLA-A
integral component of organelle membrane (GO:0031301) NEW4.850.0HLA-B, HLA-A
MHC protein complex (GO:0042611) -6.430.0HLA-B, HLA-A
membrane-bounded organelle (GO:0043227) -0.470.0HLA-B, HLA-A
organelle (GO:0043226) -0.40.0HLA-B, HLA-A
endosome membrane (GO:0010008) -3.830.0HLA-B, HLA-A
endocytic vesicle membrane (GO:0030666) -4.820.0HLA-B, HLA-A
organelle membrane (GO:0031090) -1.970.0HLA-B, HLA-A
coated vesicle membrane (GO:0030662) -5.00.0HLA-B, HLA-A
integral component of membrane (GO:0016021) -1.140.0HLA-B, HLA-A
membrane (GO:0016020) -0.680.0HLA-B, HLA-A
Golgi apparatus part (GO:0044431) -3.00.0HLA-B, HLA-A
cytoplasmic vesicle part (GO:0044433) -3.410.0HLA-B, HLA-A
endoplasmic reticulum part (GO:0044432) -2.730.0HLA-B, HLA-A
integral component of lumenal side of endoplasmic reticulum membrane (GO:0071556) -6.430.0HLA-B, HLA-A
plasma membrane part (GO:0044459) -1.950.0HLA-B, HLA-A
cell surface (GO:0009986) -3.440.0HLA-B, HLA-A
early endosome membrane (GO:0031901) -5.060.0HLA-B, HLA-A
Golgi apparatus (GO:0005794) -2.70.0HLA-B, HLA-A
bounding membrane of organelle (GO:0098588) -2.390.0HLA-B, HLA-A
transport vesicle membrane (GO:0030658) -4.860.0HLA-B, HLA-A
cytoplasmic vesicle membrane (GO:0030659) -3.670.0HLA-B, HLA-A
vesicle membrane (GO:0012506) -3.630.0HLA-B, HLA-A
ER to Golgi transport vesicle membrane (GO:0012507) -5.810.0HLA-B, HLA-A
protein complex (GO:0043234) -1.510.0HLA-B, HLA-A
MHC class I protein complex (GO:0042612) -7.240.0HLA-B, HLA-A
macromolecular complex (GO:0032991) -1.350.0HLA-B, HLA-A
intracellular membrane-bounded organelle (GO:0043231) -0.60.0HLA-B, HLA-A
phagocytic vesicle membrane (GO:0030670) -5.710.0HLA-B, HLA-A
Golgi membrane (GO:0000139) -3.280.0HLA-B, HLA-A
intracellular organelle part (GO:0044446) -0.810.0HLA-B, HLA-A
cytoplasmic part (GO:0044444) -0.820.0HLA-B, HLA-A
endosomal part (GO:0044440) -3.730.0HLA-B, HLA-A
intracellular part (GO:0044424) -0.280.0HLA-B, HLA-A
membrane part (GO:0044425) -0.950.0HLA-B, HLA-A
organelle part (GO:0044422) -0.790.0HLA-B, HLA-A