Disease table of TUBEROUS SCLEROSIS OMIM ID: PS191100

Gene-disease associations table

GeneAssociated with TUBEROUS SCLEROSIS inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
IFNGOMIMHGNC link12q155609135, PS191100, 609532, 607948, 609423
TSC1ClinVar, OMIM, HUMSAVARHGNC link9q34.133607341, 606690, PS191100
TSC2ClinVar, OMIM, HUMSAVARHGNC link16p13.33PS191100, PS142623, 606690
SERPINC1ClinVarHGNC link1q25.12PS191100, PS188050

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
ARNO83UGT2B15, PTPN1, CDH11, AKR1C3, USP26, FOLH1, CCR2, CDK20, CDK6, PNRC1, ARG1, XIAP, VIM, ARG2, EGFR, CFLAR, ETV1, BSG, IGF1R, MUC1, WEE1, PTGS2, NKX3-1, AKT1, NRAS, CDH1, EP300, KLF5, ACTA1, CLK3, FN1, TNF, PRL, ERBB2, ERBB3, CRISP3, CTNNB1, PTEN, CRISP1, SERPINB5, TSC2, NAT1, CDKN1A, GREB1, SEPT7, IFI16, PIGR, KLK3, PC, STIM1, SRD5A3, TCF7L2, JUN, TMPRSS2, RELA, TJP1, BTG1, VEGFA, NFKB1, HMMR, FKBP5, KLK4, CRH, CDH2, BTG2, TGFA, SESN1, CDC6, TH, ALDH1A3, KISS1, KISS1R, PEBP1, KLK2, ATAD2, HMOX1, TSC1, WNT7B, PEG10, TRPS1, CCND1, PIP, FOXA12TSC1, TSC2
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
IFNGYES29BCL6, TFAP4, NFATC2, TBX21, EGR1, NFKB1, CREB1, STAT5A, NFATC1, JUN, GATA1, ATF2, RELA, PARP1, GATA3, EP300, STAT1, STAT3, PROX1, RFX5, EOMES, YY1, NFIL3, STAT5B, MSC, MYCN, STAT4, IRF1, USF10
TSC1YES1AR0
TSC2YES1AR0
SERPINC1YES7CEBPA, THRA, NR2F1, FOXA2, HNF4A, RXRA, FOXA10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
TSC1TSC2Yes20FBXW5, RRAGC, GSK3B, CDKN1B, PAM, TBC1D7, YWHAE, DAPK1, PTK2, RPS6KA1, TSC1, AXIN1, YWHAZ, ESR1, YWHAB, RHEB, AKT1, PLK1, RRAGA, CIAO1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
IFNGTSC1No-4MAPK3, MAPK1, PIK3CA, CDKN1B
IFNGTSC2No-4MAPK1, MAPK3, CDKN1B, SIRT1
TSC1TSC2Yesbinding40PRKAA2, MAPK1, YWHAE, PRKAG1, AKT3, DEPTOR, TBC1D7, PRKAB1, YWHAH, MLST8, YWHAB, RHEB, RPS6KB2, YWHAZ, AKT2, SFN, PRKAA1, RPS6KA3, PRKAG2, RPS6KB1, PRR5, AKT1, GSK3B, CDK1, FBXW5, DDIT4, RPS6KA6, RPS6KA2, RICTOR, MAPK3, IKBKB, MTOR, RPS6KA1, PRKAG3, YWHAG, SGK1, MAPKAP1, UBC, YWHAQ, CDKN1B
TSC1SERPINC1No-1UBC
TSC2SERPINC1No-1UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
TSC1TSC2YesTSC1-TSC2 complex0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Insulin signaling pathwayhsa049105.552TSC1, TSC2
AMPK signaling pathwayhsa041525.82TSC1, TSC2
Choline metabolism in cancerhsa052316.092TSC1, TSC2
mTOR signaling pathwayhsa041506.722TSC1, TSC2
PI3K-Akt signaling pathwayhsa041514.212TSC1, TSC2

NET-GE enrichment

Term New enriched termICP valueGenes
mTOR signaling pathway (hsa04150) -6.720.029TSC1, TSC2
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
MacroautophagyR-HSA-16328526.922TSC1, TSC2
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.852TSC1, TSC2
Inhibition of TSC complex formation by PKBR-HSA-16518111.42TSC1, TSC2
Energy dependent regulation of mTOR by LKB1-AMPKR-HSA-3809728.182TSC1, TSC2
Transcriptional Regulation by TP53R-HSA-37009896.732TSC1, TSC2
Generic Transcription PathwayR-HSA-2124363.862TSC1, TSC2
Gene ExpressionR-HSA-741602.722TSC1, TSC2
Immune SystemR-HSA-1682562.372TSC2, IFNG
Cellular responses to stressR-HSA-22627524.562TSC1, TSC2
IRS-mediated signallingR-HSA-1123994.872TSC1, TSC2
PI3K CascadeR-HSA-1097046.682TSC1, TSC2
IGF1R signaling cascadeR-HSA-24289244.852TSC1, TSC2
PKB-mediated eventsR-HSA-1097037.662TSC1, TSC2
IRS-related events triggered by IGF1RR-HSA-24289284.852TSC1, TSC2
TP53 Regulates Metabolic GenesR-HSA-56288976.732TSC1, TSC2
mTOR signallingR-HSA-1651597.72TSC1, TSC2
Signaling by Insulin receptorR-HSA-747524.732TSC1, TSC2
Signal TransductionR-HSA-1625821.782TSC1, TSC2
Insulin receptor signalling cascadeR-HSA-747514.852TSC1, TSC2

NET-GE enrichment

Term New enriched termICP valueGenes
Macroautophagy (R-HSA-1632852) -6.920.027TSC1, TSC2
Transcriptional Regulation by TP53 (R-HSA-3700989) -6.730.035TSC1, TSC2
Inhibition of TSC complex formation by PKB (R-HSA-165181) -11.40.0TSC1, TSC2
Energy dependent regulation of mTOR by LKB1-AMPK (R-HSA-380972) -8.180.015TSC1, TSC2
mTOR signalling (R-HSA-165159) -7.70.009TSC1, TSC2
PI3K Cascade (R-HSA-109704) -6.680.037TSC1, TSC2
PKB-mediated events (R-HSA-109703) -7.660.031TSC1, TSC2
TP53 Regulates Metabolic Genes (R-HSA-5628897) -6.730.035TSC1, TSC2
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.184TSC2, TSC1, SERPINC1, IFNG
protein binding (GO:0005515) 0.464TSC2, TSC1, SERPINC1, IFNG
enzyme regulator activity (GO:0030234) 2.853TSC2, TSC1, SERPINC1
molecular function regulator (GO:0098772) 2.513TSC2, TSC1, SERPINC1
GTPase regulator activity (GO:0030695) 4.012TSC1, TSC2
nucleoside-triphosphatase regulator activity (GO:0060589) 3.922TSC1, TSC2
enzyme binding (GO:0019899) 2.272SERPINC1, TSC2

NET-GE enrichment

Term New enriched termICP valueGenes
enzyme regulator activity (GO:0030234) -2.850.018TSC2, TSC1, SERPINC1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of hydrolase activity (GO:0051336) 2.534TSC2, TSC1, SERPINC1, IFNG
negative regulation of cellular metabolic process (GO:0031324) 2.014TSC2, TSC1, IFNG, SERPINC1
regulation of cellular protein metabolic process (GO:0032268) 1.994TSC2, TSC1, IFNG, SERPINC1
negative regulation of metabolic process (GO:0009892) 1.934TSC2, TSC1, SERPINC1, IFNG
regulation of primary metabolic process (GO:0080090) 1.084TSC2, TSC1, SERPINC1, IFNG
regulation of metabolic process (GO:0019222) 1.024TSC2, TSC1, SERPINC1, IFNG
regulation of macromolecule metabolic process (GO:0060255) 1.084TSC2, TSC1, IFNG, SERPINC1
regulation of response to stimulus (GO:0048583) 1.544TSC2, TSC1, IFNG, SERPINC1
regulation of cellular metabolic process (GO:0031323) 1.074TSC2, TSC1, SERPINC1, IFNG
regulation of catalytic activity (GO:0050790) 1.974TSC2, TSC1, IFNG, SERPINC1
regulation of protein metabolic process (GO:0051246) 1.934TSC2, TSC1, SERPINC1, IFNG
regulation of cellular process (GO:0050794) 0.54TSC2, TSC1, SERPINC1, IFNG
negative regulation of macromolecule metabolic process (GO:0010605) 2.014TSC2, TSC1, IFNG, SERPINC1
biological regulation (GO:0065007) 0.394TSC2, TSC1, IFNG, SERPINC1
single-organism process (GO:0044699) 0.484TSC2, TSC1, IFNG, SERPINC1
negative regulation of biological process (GO:0048519) 1.334TSC2, TSC1, SERPINC1, IFNG
regulation of molecular function (GO:0065009) 1.784TSC2, TSC1, SERPINC1, IFNG
regulation of biological process (GO:0050789) 0.454TSC2, TSC1, IFNG, SERPINC1
negative regulation of cellular process (GO:0048523) 1.414TSC2, TSC1, SERPINC1, IFNG
regulation of phosphate metabolic process (GO:0019220) 2.353TSC1, TSC2, IFNG
negative regulation of response to stimulus (GO:0048585) 2.523TSC1, TSC2, SERPINC1
regulation of cellular component organization (GO:0051128) 2.013TSC1, TSC2, IFNG
cell cycle process (GO:0022402) 2.753TSC1, TSC2, IFNG
regulation of signaling (GO:0023051) 1.723TSC1, TSC2, IFNG
regulation of cell communication (GO:0010646) 1.733TSC1, TSC2, IFNG
positive regulation of catalytic activity (GO:0043085) 2.43TSC1, TSC2, IFNG
negative regulation of protein metabolic process (GO:0051248) 2.823TSC1, TSC2, SERPINC1
establishment of localization (GO:0051234) 1.483TSC1, TSC2, IFNG
negative regulation of cell cycle (GO:0045786) 3.673TSC1, TSC2, IFNG
positive regulation of hydrolase activity (GO:0051345) 2.913TSC1, TSC2, IFNG
regulation of signal transduction (GO:0009966) 1.843TSC1, TSC2, IFNG
positive regulation of molecular function (GO:0044093) 2.233TSC1, TSC2, IFNG
regulation of protein modification process (GO:0031399) 2.323TSC1, TSC2, IFNG
regulation of biological quality (GO:0065008) 1.683TSC1, IFNG, SERPINC1
regulation of cell proliferation (GO:0042127) 2.413TSC1, TSC2, IFNG
negative regulation of cell proliferation (GO:0008285) 3.263TSC1, TSC2, IFNG
multicellular organismal process (GO:0032501) 1.453TSC1, SERPINC1, IFNG
transport (GO:0006810) 1.513TSC1, TSC2, IFNG
cell cycle arrest (GO:0007050) 4.693TSC1, TSC2, IFNG
organic substance transport (GO:0071702) 2.153TSC1, TSC2, IFNG
establishment of localization in cell (GO:0051649) 2.473TSC1, TSC2, IFNG
response to chemical (GO:0042221) 1.983TSC1, SERPINC1, IFNG
regulation of intracellular signal transduction (GO:1902531) 2.313TSC1, TSC2, IFNG
localization (GO:0051179) 1.43TSC1, TSC2, IFNG
cellular localization (GO:0051641) 2.323TSC1, TSC2, IFNG
regulation of phosphorylation (GO:0042325) 2.53TSC1, TSC2, IFNG
regulation of phosphorus metabolic process (GO:0051174) 2.353TSC1, TSC2, IFNG
negative regulation of cellular protein metabolic process (GO:0032269) 2.883TSC2, TSC1, SERPINC1
intracellular transport (GO:0046907) 2.673TSC1, TSC2, IFNG
response to external stimulus (GO:0009605) 2.553TSC1, IFNG, SERPINC1
regulation of cell cycle (GO:0051726) 2.933TSC1, TSC2, IFNG
response to stimulus (GO:0050896) 1.223TSC1, IFNG, SERPINC1
cellular process (GO:0009987) 0.263TSC1, TSC2, IFNG
regulation of protein phosphorylation (GO:0001932) 2.573TSC1, TSC2, IFNG
nuclear transport (GO:0051169) 4.22TSC1, TSC2
protein localization (GO:0008104) 2.362TSC2, IFNG
regulation of transport (GO:0051049) 2.242TSC2, IFNG
signal transduction (GO:0007165) 1.282TSC2, IFNG
cell surface receptor signaling pathway (GO:0007166) 2.092TSC2, IFNG
regulation of defense response (GO:0031347) 3.112SERPINC1, IFNG
cellular response to stimulus (GO:0051716) 1.972TSC1, IFNG
negative regulation of signal transduction (GO:0009968) 2.752TSC1, TSC2
positive regulation of cell adhesion (GO:0045785) 3.792TSC1, IFNG
cellular developmental process (GO:0048869) 1.822TSC1, IFNG
cell activation involved in immune response (GO:0002263) 4.862TSC1, IFNG
interspecies interaction between organisms (GO:0044419) 3.082TSC2, IFNG
animal organ development (GO:0048513) 2.532TSC1, TSC2
negative regulation of molecular function (GO:0044092) 2.742SERPINC1, TSC2
positive regulation of biological process (GO:0048518) 1.22TSC1, IFNG
macromolecule localization (GO:0033036) 2.342TSC2, IFNG
chemotaxis (GO:0006935) 4.042TSC2, IFNG
T cell differentiation (GO:0030217) 5.112TSC1, IFNG
regulation of protein kinase activity (GO:0045859) 3.152TSC1, TSC2
establishment of protein localization (GO:0045184) 2.532TSC2, IFNG
lymphocyte activation (GO:0046649) 3.962TSC1, IFNG
regulation of proteolysis (GO:0030162) 3.22SERPINC1, IFNG
response to organic substance (GO:0010033) 2.22TSC1, IFNG
multi-organism process (GO:0051704) 2.652TSC2, IFNG
single-multicellular organism process (GO:0044707) 1.782SERPINC1, TSC1
response to nutrient levels (GO:0031667) 3.772SERPINC1, TSC1
immune system process (GO:0002376) 2.292TSC1, IFNG
negative regulation of cellular response to insulin stimulus (GO:1900077) 6.292TSC1, TSC2
regulation of cellular response to insulin stimulus (GO:1900076) 5.652TSC1, TSC2
T cell aggregation (GO:0070489) 4.452TSC1, IFNG
negative regulation of biosynthetic process (GO:0009890) 2.472TSC1, IFNG
leukocyte activation (GO:0045321) 3.762TSC1, IFNG
negative regulation of gene expression (GO:0010629) 2.482TSC1, IFNG
T cell activation involved in immune response (GO:0002286) 5.762TSC1, IFNG
positive regulation of GTPase activity (GO:0043547) 3.282TSC1, TSC2
lymphocyte activation involved in immune response (GO:0002285) 5.222TSC1, IFNG
intracellular protein transport (GO:0006886) 3.22TSC2, IFNG
regulation of kinase activity (GO:0043549) 3.072TSC1, TSC2
leukocyte activation involved in immune response (GO:0002366) 4.882TSC1, IFNG
neural tube closure (GO:0001843) 5.382TSC1, TSC2
lymphocyte aggregation (GO:0071593) 4.442TSC1, IFNG
anatomical structure formation involved in morphogenesis (GO:0048646) 3.012TSC1, TSC2
positive regulation of cellular component organization (GO:0051130) 2.682TSC1, IFNG
single organism cell adhesion (GO:0098602) 3.632TSC1, IFNG
cell-cell adhesion (GO:0098609) 3.342TSC1, IFNG
regulation of biosynthetic process (GO:0009889) 1.372TSC1, IFNG
tube closure (GO:0060606) 5.362TSC1, TSC2
cell activation (GO:0001775) 3.472TSC1, IFNG
regulation of multicellular organismal process (GO:0051239) 1.872SERPINC1, IFNG
immune response (GO:0006955) 2.862TSC1, IFNG
negative regulation of intracellular signal transduction (GO:1902532) 3.632TSC1, TSC2
regulation of dephosphorylation (GO:0035303) 4.672TSC1, IFNG
leukocyte differentiation (GO:0002521) 4.132TSC1, IFNG
T cell differentiation involved in immune response (GO:0002292) 6.592TSC1, IFNG
taxis (GO:0042330) 4.032TSC2, IFNG
regulation of response to stress (GO:0080134) 2.532SERPINC1, IFNG
regulation of transferase activity (GO:0051338) 2.882TSC1, TSC2
regulation of macromolecule biosynthetic process (GO:0010556) 1.432TSC1, IFNG
negative regulation of TOR signaling (GO:0032007) 6.172TSC1, TSC2
regulation of TOR signaling (GO:0032006) 5.442TSC1, TSC2
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532TSC1, IFNG
regulation of phosphatase activity (GO:0010921) 4.882TSC1, IFNG
regulation of cell adhesion (GO:0030155) 3.272TSC1, IFNG
cell differentiation (GO:0030154) 2.142TSC1, IFNG
tube formation (GO:0035148) 4.982TSC1, TSC2
negative regulation of signaling (GO:0023057) 2.652TSC1, TSC2
negative regulation of cell communication (GO:0010648) 2.662TSC1, TSC2
cellular response to chemical stimulus (GO:0070887) 2.572TSC1, IFNG
regulation of GTPase activity (GO:0043087) 3.212TSC1, TSC2
negative regulation of catalytic activity (GO:0043086) 3.02SERPINC1, TSC2
biological adhesion (GO:0022610) 2.812TSC1, IFNG
developmental process (GO:0032502) 1.362TSC1, TSC2
locomotion (GO:0040011) 2.912TSC2, IFNG
regulation of vesicle-mediated transport (GO:0060627) 3.632TSC2, IFNG
regulation of localization (GO:0032879) 1.942TSC2, IFNG
lymphocyte differentiation (GO:0030098) 4.492TSC1, IFNG
response to extracellular stimulus (GO:0009991) 3.712SERPINC1, TSC1
single organismal cell-cell adhesion (GO:0016337) 3.692TSC1, IFNG
negative regulation of cellular biosynthetic process (GO:0031327) 2.492TSC1, IFNG
regulation of cellular biosynthetic process (GO:0031326) 1.382TSC1, IFNG
T cell activation (GO:0042110) 4.452TSC1, IFNG
regulation of cell death (GO:0010941) 2.432TSC1, IFNG
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462TSC1, IFNG
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62TSC1, IFNG
regulation of autophagy (GO:0010506) 4.212TSC1, IFNG
regulation of gene expression (GO:0010468) 1.372TSC1, IFNG
nucleocytoplasmic transport (GO:0006913) 4.232TSC1, TSC2
regulation of insulin receptor signaling pathway (GO:0046626) 5.972TSC1, TSC2
negative regulation of insulin receptor signaling pathway (GO:0046627) 6.362TSC1, TSC2
single-organism developmental process (GO:0044767) 1.492TSC1, TSC2
single-organism transport (GO:0044765) 2.182TSC1, TSC2
multi-organism cellular process (GO:0044764) 3.142TSC2, IFNG
single-organism cellular process (GO:0044763) 0.652TSC1, IFNG
regulation of nitrogen compound metabolic process (GO:0051171) 1.362TSC1, IFNG
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472TSC1, IFNG
single-organism intracellular transport (GO:1902582) 3.592TSC1, TSC2
cell adhesion (GO:0007155) 2.822TSC1, IFNG
leukocyte aggregation (GO:0070486) 4.412TSC1, IFNG
leukocyte cell-cell adhesion (GO:0007159) 4.262TSC1, IFNG
single-organism localization (GO:1902578) 2.092TSC1, TSC2
response to oxygen-containing compound (GO:1901700) 2.572TSC1, IFNG
anatomical structure development (GO:0048856) 1.582TSC1, TSC2
adaptive immune response (GO:0002250) 4.432TSC1, IFNG
viral process (GO:0016032) 3.152TSC2, IFNG
immune effector process (GO:0002252) 3.582TSC1, IFNG
protein transport (GO:0015031) 2.622TSC2, IFNG
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.152TSC2, IFNG
single-organism cellular localization (GO:1902580) 3.162TSC1, TSC2
positive regulation of cellular process (GO:0048522) 1.32TSC1, IFNG

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of hydrolase activity (GO:0051336) -2.530.014TSC2, TSC1, IFNG, SERPINC1
negative regulation of cell size (GO:0045792) NEW7.530.007TSC1, TSC2
negative regulation of cell cycle (GO:0045786) -3.670.008TSC1, TSC2, IFNG
posttranscriptional regulation of gene expression (GO:0010608) NEW3.640.03TSC2, TSC1, SERPINC1, IFNG
regulation of cell adhesion (GO:0030155) -3.270.016TSC2, TSC1, SERPINC1, IFNG
regulation of insulin receptor signaling pathway (GO:0046626) -5.970.014TSC1, TSC2
negative regulation of insulin receptor signaling pathway (GO:0046627) -6.360.038TSC1, TSC2
cell cycle arrest (GO:0007050) -4.690.039TSC1, TSC2, IFNG
regulation of cell size (GO:0008361) NEW5.420.011TSC1, TSC2
negative regulation of cellular response to insulin stimulus (GO:1900077) -6.290.009TSC1, TSC2
regulation of cellular response to insulin stimulus (GO:1900076) -5.650.023TSC1, TSC2
negative regulation of TOR signaling (GO:0032007) -6.170.005TSC1, TSC2
regulation of TOR signaling (GO:0032006) -5.440.024TSC1, TSC2
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.114TSC2, TSC1, SERPINC1, IFNG
membrane (GO:0016020) 0.683TSC2, TSC1, SERPINC1
membrane-bounded organelle (GO:0043227) 0.473TSC1, TSC2, SERPINC1
organelle (GO:0043226) 0.43TSC1, TSC2, SERPINC1
TSC1-TSC2 complex (GO:0033596) 8.72TSC1, TSC2
cytoplasm (GO:0005737) 1.012TSC1, TSC2
macromolecular complex (GO:0032991) 1.352TSC1, TSC2
extracellular space (GO:0005615) 2.632SERPINC1, IFNG
cytosolic part (GO:0044445) 4.342TSC1, TSC2
nucleus (GO:0005634) 1.072TSC1, TSC2
cytoplasmic part (GO:0044444) 0.822TSC1, TSC2
extracellular region part (GO:0044421) 1.572SERPINC1, IFNG
intracellular organelle (GO:0043229) 0.512TSC1, TSC2
extracellular region (GO:0005576) 2.182SERPINC1, IFNG
plasma membrane (GO:0005886) 1.392SERPINC1, TSC1
intracellular part (GO:0044424) 0.282TSC1, TSC2
protein complex (GO:0043234) 1.512TSC1, TSC2
perinuclear region of cytoplasm (GO:0048471) 3.352TSC1, TSC2
cytosol (GO:0005829) 1.682TSC1, TSC2
intracellular membrane-bounded organelle (GO:0043231) 0.62TSC1, TSC2

NET-GE enrichment

Term New enriched termICP valueGenes
TSC1-TSC2 complex (GO:0033596) -8.70.0TSC1, TSC2
cytosolic part (GO:0044445) -4.340.024TSC1, TSC2
site of polarized growth (GO:0030427) NEW4.850.01TSC1, TSC2
growth cone (GO:0030426) NEW4.890.01TSC1, TSC2