Disease table of THREE M SYNDROME OMIM ID: PS273750

Gene-disease associations table

GeneAssociated with THREE M SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
CCDC8ClinVar, OMIMHGNC link19q13.321PS273750
CUL7ClinVar, OMIM, HUMSAVARHGNC link6p21.11PS273750
OBSL1ClinVar, OMIMHGNC link2q351PS273750

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
CCDC8CUL7Yes254SF1, ARHGDIA, DDX5, KRT14, STIP1, GART, NOC2L, ILF3, TP53, MARS, PPP2R1A, IGF2BP3, RPL8, SNRNP200, ATP2A2, ACTN4, CCT6A, RTCB, VCP, LDHA, RAB14, SYNCRIP, DHX9, STOML2, NPEPPS, TPR, MAPK14, MATR3, PFKL, MKI67, SMC1A, PFKP, SLC3A2, HSD17B4, OBSL1, PDIA6, ELAVL1, GCN1L1, HNRNPA1, SMC3, TMOD3, RPL11, TIMM50, ZNF326, EPRS, FBXW8, SND1, SLC1A5, FLOT2, FBL, FLNA, ANXA2, TJP1, KPNA2, POLR2A, YWHAG, FLNB, NCL, TRIM25, HNRNPA0, RPL7, CANX, PRPF8, NOP2, BAZ1B, RPS8, NUMA1, RRP1B, MCM7, MAP1B, RPS4X, FASN, HSP90AB1, SEC22B, EWSR1, SF3B1, NUP93, TMPO, HSP90B1, LMNB1, CCT3, TNPO1, PCBP2, RPL6, SRSF9, DYNC1H1, FXR1, HLA-C, CLTC, RPS14, RAB1A, ZC3H14, HSPA9, CPSF6, DSG2, RPL10A, GAPDH, RPLP0, IQGAP1, MDN1, SART1, CEP250, ETFA, RUVBL2, ANKRA2, HSPD1, IMMT, HIST1H4L, STAU1, SMARCA5, SMCHD1, RPL7A, IARS, RCC2, PDIA4, RPS3A, PPP1CA, CAPZA2, EEF1A1, CUL7, ATP5F1, NONO, UBC, TOP2A, EIF4A1, YWHAQ, MLLT4, RPL18, HNRNPR, ATAD3A, TUFM, RBM14, PABPC1, TPI1, HNRNPU, ACSL3, RPA1, PHGDH, CDK1, CASQ2, HSPA5, HNRNPL, LIMA1, PHB, RPS18, SFPQ, MAPK11, RBMX, HNRNPF, CCT8, TCP1, PLEC, RALA, COPA, MYBBP1A, LRPPRC, EEF1G, ENO1, GNA13, UBA1, MACF1, RPL14, SF3B3, YWHAE, DDX21, PRKDC, CCT2, CAPZB, HIST1H1E, GOLGB1, SLC12A2, FLOT1, LMNB2, ATP1A1, RPL3, DRG1, PRPF6, GRN, CHCHD3, EMD, HADHA, DDX3X, CCT7, XRCC6, ATP5A1, CCDC8, LMNA, DDX17, MTHFD1, PKM, ILF2, PABPC4, XRCC5, NUP155, ATP5B, TUBB6, NOP58, QARS, HDAC2, CKAP4, TRAP1, KRT5, RPS3, CAD, LRRC59, HEATR1, POLDIP3, IGF2BP1, AURKB, NUP205, USP39, AHNAK, DDX50, PSMD2, PGRMC1, NPM1, KHDRBS1, RPL9, PDCD11, KPNB1, P4HB, MDH2, EIF4G1, SERPINH1, DARS, CHD4, KRT18, RUVBL1, RAB5C, PRKAR1A, JUP, KHSRP, TRIM28, HNRNPH3, PARP1, PA2G4, DSP, LGALS3BP, NNT, CKB, PTBP1, ACLY, ZFR, MYO1B, EPPK1, YBX1, PDIA3, HNRNPH1, NOP56, EFTUD2, RANBP2, POLR2E, HLA-A, RPS2
CCDC8OBSL1Yes239SF1, DDX5, KRT14, NOC2L, TRIM28, HNRNPR, TP53, DDX21, IGF2BP3, ITPR3, RPL6, SNRNP200, NOP58, ACTN4, HNRNPL, RTCB, VCP, RPL5, MLLT4, SYNCRIP, DHX9, RPL3, STOML2, TPR, MAPK14, MATR3, MKI67, DHX30, PDIA3, OBSL1, SND1, UTRN, GCN1L1, SMC3, RPL11, UHRF1, ZNF326, SCIN, FBXW8, FLNB, EP400, SNRPB2, FLOT2, FBL, FLNA, ANXA2, TJP1, MCM3, KPNA2, PCBP2, CHTOP, DST, RPS2, HNRNPA0, RPL7, ATAD3A, PRPF8, MCM5, NOP2, BAZ1B, RPS8, NUMA1, SRSF9, MCM7, NDC1, HDLBP, FASN, HSP90AB1, SEC22B, EWSR1, SF3B1, NUP93, KRT5, TMPO, HSP90B1, LMNB1, GTF3C1, TNPO1, POLR2A, RPL8, DYNC1H1, SMARCC2, LMNA, CLTC, EIF3A, ZC3H14, HSPA9, CPSF6, DSG2, SUGP2, RPL10A, GAPDH, RPLP0, HERC2, IQGAP1, SART1, RCC2, CGN, MDN1, RUVBL2, ANKRA2, HSPD1, IMMT, HIST1H4L, ALB, SMCHD1, RPL7A, TUFM, SCRIB, PDIA6, NEFL, PDIA4, JUP, LRRC59, CAPZA2, CUL7, ATP5A1, DDX50, UBC, KHSRP, EIF4A1, YWHAQ, LDHA, EFTUD2, TRIP12, RBM14, PABPC1, TPI1, ACSL3, CCT6A, PHGDH, HNRNPA1, HSPA5, LIMA1, ILF3, CTNNA1, TRA2B, PHB, SFPQ, MAPK11, RBMX, MCM2, CCT8, TCP1, PLEC, MYBBP1A, EEF1G, ENO1, UBA1, MACF1, CTNNB1, AHNAK, SF3B3, YWHAE, PRKDC, NIPBL, CCT2, CAPZB, HNRNPF, GOLGB1, PPP2R1A, FLOT1, LMNB2, EEF1A1, PCM1, PRPF6, POLDIP3, CHCHD3, EMD, DDX3X, XRCC6, RPS4X, CCDC8, DDX17, HNRNPU, PKM, ILF2, NONO, XRCC5, NUP155, ATP5B, CDK1, EPPK1, HDAC2, CKAP4, TRAP1, SMC1A, XPO1, CAD, PPP1CA, HEATR1, IGF2BP1, MCM6, NUP205, USP39, RPL14, COPA, PSMD2, TIMM50, NPM1, KHDRBS1, ABCF1, PDCD11, KPNB1, NCL, MDH2, CHAF1B, RRP1B, UTP20, SERPINH1, CHD4, CASQ2, KRT18, RUVBL1, SPTBN2, SMARCA5, RPS3A, TOP2A, ELAVL1, HNRNPH3, PARP1, PA2G4, DSP, LGALS3BP, NUP188, CKB, PTBP1, ACLY, ZFR, HIST1H1E, YBX1, HNRNPH1, NOP56, RPL18, RANBP2, POLR2E, PCNT, CCT3, CCAR2
CUL7OBSL1Yes441EIF4A3, KRT14, CDC5L, UBTF, DDB1, PSIP1, RNPS1, ANXA1, DDX27, SYNCRIP, CCT8, STOML2, MAPK14, LMNA, SNRPD3, SUPT6H, TEX10, SNRPB, CPSF1, TP53, PCNA, H2AFV, RBM15, POLR2A, NUP98, GANAB, CSNK2A1, ATAD3A, HIST4H4, BAZ1B, RPS4X, ARPC3, EWSR1, SNW1, RPL10A, ACTR3, MDH2, SEC23A, NOC2L, RPL8, LBR, HSPA9, NIFK, GAPDH, MDN1, RBM14-RBM4, LGALS3BP, WDR75, WDR36, KRT17, SMCHD1, RPL7A, HIST1H4D, ADAR, HIST1H4F, HIST2H2AA3, SRRT, HNRNPR, VCP, U2AF2, DHX16, CIT, NOL11, CPSF6, THOC2, LUC7L3, ILF2, OBSL1, RPL14, DDX1, CAPZB, HNRNPF, SF3A3, CCDC8, RSL1D1, HIST1H4J, NUP155, DDX18, PDIA4, SAFB2, KRT5, CAD, IGF2BP1, TLN1, HIST2H4A, DKC1, GPI, EIF6, CAPZA1, HIST2H3C, RPSA, U2SURP, DEK, NIPSNAP1, SPEN, RPS3A, TOP2A, ELAVL1, PARP1, PA2G4, DDX56, PPIA, ACLY, GCN1L1, CBX3, HNRNPDL, RPL18, CPSF7, RALY, SF1, PSMD2, DDX21, NONO, LMNB1, NOLC1, KHDRBS1, CENPF, DHX9, MAPK11, HIST2H2AA4, PHIP, TOP1, MKI67, SMC1A, SRSF10, TUBB2B, SND1, BAG2, FUBP3, RRP15, FBXW8, ACSL3, HIST1H2BN, FLOT2, FBL, KPNB1, DDX42, KPNA2, SUPT5H, PHGDH, NOP2, PRDX1, SF3B2, RRP1B, RPF2, ATP5A1, BOP1, C1QBP, ANKRA2, HSP90B1, GSN, CSNK2B, XRN2, HIST2H4B, CHD4, FLNB, PFN1, DYNC1H1, RPLP0, HNRNPA3, CCT6A, NUDT21, TUFM, PDIA6, RBM14, JUP, RPL7, RBM4, YWHAQ, EFTUD2, PABPC1, U2AF1, MDC1, RANGAP1, NUP160, HIST1H4I, CASQ2, GNL2, SNRPA, SUMO1, MYBBP1A, YBX1, PCMT1, FIP1L1, AHNAK, RPL7L1, SAFB, DAZAP1, PSPC1, PRPF6, ACIN1, DSG2, PKM, CUL7, ATP5B, CDK1, NOP58, SLC25A5, NUP214, CKAP4, WDR18, CSTF2, GNB2L1, WDR43, HIST1H4A, SRSF7, RUVBL1, SNRPA1, SRSF1, HIST1H4H, HNRNPL, PCBP1, KRT18, NUP93, ALYREF, RPL23A, CKB, PPAN, POLDIP3, ZFR, SMU1, PDIA3, POLR2E, ILF3, SON, ZC3H11A, IGF2BP3, RPL6, H2AFY2, TOP2B, SNRPE, TAGLN2, RPL3, TPR, EEF1A1, NCOA5, TAF15, RAN, SNRNP70, MRE11A, CBX5, TRIM28, RPL15, EPPK1, DHX15, SMC3, RPL11, ZNF326, ACTBL2, CORO1C, SF3A1, TJP1, GNL3, PCBP2, BCLAF1, SRSF3, ATP5O, HNRNPA1, XRCC6, RPS8, YWHAE, CALD1, TPM3, EBNA1BP2, HIST2H2BE, PRMT1, PTBP1, ACTN4, SEC22B, H2AFY, ZC3H14, RRP9, SART1, HP1BP3, HIST1H4K, HSPD1, NUP35, HIST1H4L, ACTR2, HDAC2, SF3A2, LRRC59, TBL3, HBA1, SERPINH1, UBC, EIF4A1, RBBP4, LDHA, MYEF2, RTCB, TPI1, HNRNPH2, RPL19, HSPA5, LIMA1, CBX1, PHB, SFPQ, IMMT, HNRNPA2B1, INA, RBM10, ENO1, UBA1, MACF1, TRAP1, PRKDC, CCT2, SYNE2, HIST1H1E, PRDX3, PPP2R1A, EMD, HNRNPA0, HNRNPU, DDX46, RBM39, PUF60, PLEC, SSRP1, RPS9, PPP1CA, HEATR1, TUBA1B, BRIX1, HBA2, USP39, IK, SHMT2, CAPZA2, NPM1, SNRNP40, RPL13, NCL, SRSF9, AAAS, NUP107, IGHG1, SUPT16H, SMARCA5, KHSRP, HNRNPH3, DDX50, PRPF19, TIAL1, PTPLAD1, TCOF1, RANBP2, RPS2, DDX5, WDR3, HIST2H3D, SNRNP200, DDX23, MLLT4, ACTA1, RAE1, LAS1L, LMNB2, PPIB, GTPBP4, FASN, FLNA, ANXA2, HMGA1, HIST1H4E, HNRNPD, PRPF8, HIST1H4C, RIF1, MCM7, ACTN1, HIST1H4B, SF3B1, CHD1, CLTC, NAT10, CCT3, TNPO1, HIST2H3A, IQGAP1, NUP210, TUBA4A, RUVBL2, RCC2, TIMM50, HNRNPK, PELP1, RCC1, MATR3, DDX6, RPS6, ZNF638, HSD17B10, CCT5, SRSF6, TCP1, HNRNPAB, DSP, HNRNPUL2, HSP90AB1, EEF1G, PES1, NUMA1, RRS1, HNRNPUL1, GOLGB1, FLOT1, RPL12, CHCHD3, FUS, DDX3X, TUBB4B, FUBP1, THRAP3, TMPO, RRP12, DDX47, PNN, RAD50, SRRM2, EZR, NUP205, DDX39B, COPA, CIZ1, RBMX, PWP2, PDCD11, YWHAZ, PRPF40A, SF3B3, ARPC2, HNRNPC, XRCC5, H1FX, DDX17, RBM25, HNRNPH1, NOP56

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
CCDC8CUL7No-3MAPK14, OBSL1, TP53
CCDC8OBSL1Yesbinding1MAPK14
CUL7OBSL1Yesbinding2MAPK14, FBXW8

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
CCDC8CUL7yes, complexComponents of the 3M complex, composed of core components CUL7, CCDC8 and OBSL1. [UniProt]
CCDC8OBSL1yes, complexComponents of the 3M complex, composed of core components CUL7, CCDC8 and OBSL1. [UniProt]
CUL7OBSL1yes, complexComponents of the 3M complex, composed of core components CUL7, CCDC8 and OBSL1. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.182OBSL1, CUL7
protein binding (GO:0005515) 0.462OBSL1, CUL7

NET-GE enrichment

Term New enriched termICP valueGenes
protein binding, bridging (GO:0030674) NEW4.680.005OBSL1, CUL7
cytoskeletal adaptor activity (GO:0008093) NEW6.970.022OBSL1, CUL7
binding, bridging (GO:0060090) NEW4.570.006OBSL1, CUL7
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
organelle organization (GO:0006996) 2.023OBSL1, CUL7, CCDC8
regulation of mitotic cell cycle (GO:0007346) 3.713OBSL1, CUL7, CCDC8
regulation of mitotic nuclear division (GO:0007088) 4.833OBSL1, CUL7, CCDC8
cytoskeleton organization (GO:0007010) 3.223OBSL1, CUL7, CCDC8
regulation of organelle organization (GO:0033043) 2.723OBSL1, CUL7, CCDC8
cellular process (GO:0009987) 0.263OBSL1, CUL7, CCDC8
regulation of cell cycle process (GO:0010564) 3.53OBSL1, CUL7, CCDC8
cellular component organization (GO:0016043) 1.243OBSL1, CUL7, CCDC8
regulation of cellular process (GO:0050794) 0.53OBSL1, CUL7, CCDC8
regulation of nuclear division (GO:0051783) 4.673OBSL1, CUL7, CCDC8
single-organism cellular process (GO:0044763) 0.653OBSL1, CUL7, CCDC8
single-organism organelle organization (GO:1902589) 2.683OBSL1, CUL7, CCDC8
microtubule-based process (GO:0007017) 3.543OBSL1, CUL7, CCDC8
biological regulation (GO:0065007) 0.393OBSL1, CUL7, CCDC8
single-organism process (GO:0044699) 0.483OBSL1, CUL7, CCDC8
regulation of cell cycle (GO:0051726) 2.933OBSL1, CUL7, CCDC8
microtubule cytoskeleton organization (GO:0000226) 4.133OBSL1, CUL7, CCDC8
regulation of cellular component organization (GO:0051128) 2.013OBSL1, CUL7, CCDC8
regulation of biological process (GO:0050789) 0.453OBSL1, CUL7, CCDC8
cellular component organization or biogenesis (GO:0071840) 1.223OBSL1, CUL7, CCDC8
regulation of cell morphogenesis (GO:0022604) 3.42OBSL1, CUL7
developmental process (GO:0032502) 1.362OBSL1, CUL7
regulation of multicellular organismal process (GO:0051239) 1.872OBSL1, CUL7
regulation of anatomical structure morphogenesis (GO:0022603) 2.792OBSL1, CUL7
regulation of cell projection organization (GO:0031344) 3.382OBSL1, CUL7
positive regulation of cell projection organization (GO:0031346) 3.992OBSL1, CUL7
regulation of neurogenesis (GO:0050767) 3.212OBSL1, CUL7
positive regulation of dendrite development (GO:1900006) 5.572OBSL1, CUL7
positive regulation of multicellular organismal process (GO:0051240) 2.492OBSL1, CUL7
regulation of cell development (GO:0060284) 3.012OBSL1, CUL7
positive regulation of neurogenesis (GO:0050769) 3.772OBSL1, CUL7
regulation of neuron differentiation (GO:0045664) 3.392OBSL1, CUL7
positive regulation of neuron differentiation (GO:0045666) 3.982OBSL1, CUL7
positive regulation of cell development (GO:0010720) 3.572OBSL1, CUL7
positive regulation of biological process (GO:0048518) 1.22OBSL1, CUL7
positive regulation of cellular component organization (GO:0051130) 2.682OBSL1, CUL7
regulation of developmental process (GO:0050793) 2.12OBSL1, CUL7
single-organism developmental process (GO:0044767) 1.492OBSL1, CUL7
regulation of cell differentiation (GO:0045595) 2.422OBSL1, CUL7
positive regulation of neuron projection development (GO:0010976) 4.262OBSL1, CUL7
regulation of neuron projection development (GO:0010975) 3.692OBSL1, CUL7
regulation of cell morphogenesis involved in differentiation (GO:0010769) 3.912OBSL1, CUL7
positive regulation of dendrite morphogenesis (GO:0050775) 6.262OBSL1, CUL7
positive regulation of cell differentiation (GO:0045597) 3.012OBSL1, CUL7
Golgi organization (GO:0007030) 5.32OBSL1, CUL7
regulation of dendrite development (GO:0050773) 4.932OBSL1, CUL7
positive regulation of developmental process (GO:0051094) 2.772OBSL1, CUL7
positive regulation of nervous system development (GO:0051962) 3.642OBSL1, CUL7
regulation of nervous system development (GO:0051960) 3.12OBSL1, CUL7
regulation of multicellular organismal development (GO:2000026) 2.312OBSL1, CUL7
regulation of dendrite morphogenesis (GO:0048814) 5.412OBSL1, CUL7
positive regulation of cell morphogenesis involved in differentiation (GO:0010770) 4.652OBSL1, CUL7
positive regulation of cellular process (GO:0048522) 1.32OBSL1, CUL7

NET-GE enrichment

Term New enriched termICP valueGenes
positive regulation of dendrite morphogenesis (GO:0050775) -6.260.0OBSL1, CUL7
Golgi organization (GO:0007030) -5.30.016OBSL1, CUL7
microtubule-based process (GO:0007017) -3.540.003OBSL1, CUL7, CCDC8
cytoskeleton organization (GO:0007010) -3.220.007OBSL1, CUL7, CCDC8
actomyosin structure organization (GO:0031032) NEW5.40.027OBSL1, CUL7
regulation of dendrite development (GO:0050773) -4.930.012OBSL1, CUL7
regulation of cell cycle (GO:0051726) -2.930.016OBSL1, CUL7, CCDC8
myofibril assembly (GO:0030239) NEW6.430.003OBSL1, CUL7
regulation of cell cycle process (GO:0010564) -3.50.003OBSL1, CUL7, CCDC8
regulation of mitotic cell cycle (GO:0007346) -3.710.031OBSL1, CUL7, CCDC8
positive regulation of neurogenesis (GO:0050769) -3.770.031OBSL1, CUL7
regulation of nuclear division (GO:0051783) -4.670.0OBSL1, CUL7, CCDC8
regulation of organelle organization (GO:0033043) -2.720.012OBSL1, CUL7, CCDC8
cardiac myofibril assembly (GO:0055003) NEW7.020.002OBSL1, CUL7
microtubule cytoskeleton organization (GO:0000226) -4.130.005OBSL1, CUL7, CCDC8
regulation of dendrite morphogenesis (GO:0048814) -5.410.005OBSL1, CUL7
regulation of mitosis (GO:0007088) -4.830.0OBSL1, CUL7, CCDC8
regulation of cell division (GO:0051302) NEW4.880.008OBSL1, CUL7, CCDC8
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cytoskeleton (GO:0005856) 2.553OBSL1, CUL7, CCDC8
cytoplasm (GO:0005737) 1.013OBSL1, CUL7, CCDC8
macromolecular complex (GO:0032991) 1.353OBSL1, CUL7, CCDC8
intracellular non-membrane-bounded organelle (GO:0043232) 1.763OBSL1, CUL7, CCDC8
centrosome (GO:0005813) 3.753OBSL1, CUL7, CCDC8
3M complex (GO:1990393) 8.423OBSL1, CUL7, CCDC8
cell part (GO:0044464) 0.113OBSL1, CUL7, CCDC8
microtubule organizing center (GO:0005815) 3.423OBSL1, CUL7, CCDC8
intracellular organelle part (GO:0044446) 0.813OBSL1, CUL7, CCDC8
intracellular organelle (GO:0043229) 0.513OBSL1, CUL7, CCDC8
non-membrane-bounded organelle (GO:0043228) 1.763OBSL1, CUL7, CCDC8
cytoskeletal part (GO:0044430) 2.493OBSL1, CUL7, CCDC8
intracellular part (GO:0044424) 0.283OBSL1, CUL7, CCDC8
protein complex (GO:0043234) 1.513OBSL1, CUL7, CCDC8
organelle (GO:0043226) 0.43OBSL1, CUL7, CCDC8
organelle part (GO:0044422) 0.793OBSL1, CUL7, CCDC8
Golgi apparatus (GO:0005794) 2.72OBSL1, CUL7
perinuclear region of cytoplasm (GO:0048471) 3.352OBSL1, CUL7
cytoplasmic part (GO:0044444) 0.822OBSL1, CUL7
membrane-bounded organelle (GO:0043227) 0.472OBSL1, CUL7
intracellular membrane-bounded organelle (GO:0043231) 0.62OBSL1, CUL7

NET-GE enrichment

Term New enriched termICP valueGenes
M band (GO:0031430) NEW6.760.001OBSL1, CUL7
centrosome (GO:0005813) -3.750.0OBSL1, CUL7, CCDC8
3M complex (GO:1990393) -8.420.0OBSL1, CUL7, CCDC8
microtubule organizing center (GO:0005815) -3.420.001OBSL1, CUL7, CCDC8
intercalated disc (GO:0014704) NEW5.930.002OBSL1, CUL7
cytoskeletal part (GO:0044430) -2.490.018OBSL1, CUL7, CCDC8
cell-cell contact zone (GO:0044291) NEW5.690.004OBSL1, CUL7
Z disc (GO:0030018) NEW5.110.026OBSL1, CUL7