Disease table of WILMS TUMOR OMIM ID: PS194070

Gene-disease associations table

GeneAssociated with WILMS TUMOR inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
H19ClinVar, OMIMHGNC link11p15.53130650, PS194070, 180860
BRCA2ClinVar, OMIMHGNC link13q13.18PS227650, PS194070, 155255, 114480, 176807, PS137800, 613347, PS604370
WT1ClinVar, OMIM, HUMSAVARHGNC link11p136194080, PS194070, PS256300, 608978, 156240, 136680
RESTClinVar, OMIMHGNC link4q121PS194070
POU6F2ClinVar, OMIM, HUMSAVARHGNC link7p14.11PS194070
GPC3ClinVar, OMIMHGNC linkXq26.22312870, PS194070

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
11p12WT1, H19
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
11p2WT1, H19
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
112WT1, H19
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
WT1YES51MYC, NR5A1, CTGF, AR, CD97, TBXA2R, MYB, EGFR, HBEGF, DNMT3A, ITGAX, CCNE1, ABCB1, EREG, THBS1, CIAO1, NOV, NDRG2, SMAD3, CD14, SNAI2, NPHS1, CDKN1A, PDGFA, TERT, IRF8, VDR, PODXL, CDH1, STIM1, JUN, CKM, AMH, CYP19A1, VEGFA, VEGFB, ODC1, ETS1, KLK3, JUNB, BCL2, IGF1R, PAX2, IGF2, IL2RB, MYCN, IGF1, SRY, UBE2I, CX3CL1, CAMP0
RESTYES29SCG3, KCNN4, TPH2, NRP1, AVP, GLRA1, TUBB3, CACNA1H, OPRM1, CARTPT, SYN1, CHGA, GABRB3, CD59, GRIN2B, KCNQ3, TAC3, VGF, VIP, BDNF, LIN28A, CHGB, GJD2, PCSK1, PENK, TAC1, GRIN1, DYRK1A, KCNQ20
NFKB1NO306NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC62WT1, BRCA2
RELANO302NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC62WT1, BRCA2
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
BRCA2YES11ESR2, CTBP1, HDAC1, ELF1, TP53, USF2, RELA, PARP1, BRCA1, NFKB1, USF10
WT1YES10ZHX3, EP300, IFI16, PAX2, TFCP2, GATA1, RELA, PAX8, NFKB1, GATA20
RESTYES1SP10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
BRCA2WT1No1TP53
BRCA2RESTNo2SP1, PLK1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
BRCA2WT1No-1TP53
WT1GPC3No-6IGF1R, PTCH1, IGF2, SDC1, MYC, WNT4

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
BRCA2RESTNo-1RCOR1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.185WT1, REST, BRCA2, GPC3, POU6F2
protein binding (GO:0005515) 0.464WT1, REST, BRCA2, GPC3
organic cyclic compound binding (GO:0097159) 1.054WT1, REST, BRCA2, POU6F2
heterocyclic compound binding (GO:1901363) 1.064WT1, REST, BRCA2, POU6F2
nucleic acid binding (GO:0003676) 1.444WT1, REST, BRCA2, POU6F2
DNA binding (GO:0003677) 1.924WT1, REST, BRCA2, POU6F2
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.653WT1, REST, POU6F2
nucleic acid binding transcription factor activity (GO:0001071) 2.653WT1, REST, POU6F2
transcription regulatory region DNA binding (GO:0044212) 3.032WT1, REST
sequence-specific DNA binding (GO:0043565) 2.792WT1, REST
regulatory region nucleic acid binding (GO:0001067) 3.032WT1, REST
cation binding (GO:0043169) 1.42WT1, REST
ion binding (GO:0043167) 1.362WT1, REST
catalytic activity (GO:0003824) 1.052REST, BRCA2
regulatory region DNA binding (GO:0000975) 3.032WT1, REST
metal ion binding (GO:0046872) 1.412WT1, REST
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0000982) 3.942WT1, REST
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.292WT1, REST
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228) 3.982WT1, REST
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of primary metabolic process (GO:0080090) 1.085WT1, REST, BRCA2, GPC3, POU6F2
regulation of metabolic process (GO:0019222) 1.025WT1, REST, BRCA2, GPC3, POU6F2
regulation of cellular biosynthetic process (GO:0031326) 1.385WT1, REST, BRCA2, GPC3, POU6F2
regulation of cellular metabolic process (GO:0031323) 1.075WT1, REST, BRCA2, GPC3, POU6F2
nitrogen compound metabolic process (GO:0006807) 1.135WT1, GPC3, BRCA2, REST, POU6F2
regulation of biological process (GO:0050789) 0.455WT1, GPC3, BRCA2, REST, POU6F2
single-organism process (GO:0044699) 0.485WT1, REST, BRCA2, GPC3, POU6F2
organic substance biosynthetic process (GO:1901576) 1.345WT1, REST, BRCA2, GPC3, POU6F2
cellular developmental process (GO:0048869) 1.825WT1, REST, BRCA2, GPC3, POU6F2
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.465WT1, GPC3, BRCA2, REST, POU6F2
organic substance metabolic process (GO:0071704) 0.635WT1, GPC3, BRCA2, REST, POU6F2
biological regulation (GO:0065007) 0.395WT1, REST, BRCA2, GPC3, POU6F2
regulation of gene expression (GO:0010468) 1.375WT1, GPC3, BRCA2, REST, POU6F2
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.435WT1, GPC3, BRCA2, REST, POU6F2
cellular process (GO:0009987) 0.265WT1, GPC3, BRCA2, REST, POU6F2
regulation of biosynthetic process (GO:0009889) 1.375WT1, REST, BRCA2, GPC3, POU6F2
regulation of nucleic acid-templated transcription (GO:1903506) 1.555WT1, REST, BRCA2, GPC3, POU6F2
regulation of cellular process (GO:0050794) 0.55WT1, REST, BRCA2, GPC3, POU6F2
biosynthetic process (GO:0009058) 1.325WT1, GPC3, BRCA2, REST, POU6F2
macromolecule biosynthetic process (GO:0009059) 1.615WT1, REST, BRCA2, GPC3, POU6F2
single-organism cellular process (GO:0044763) 0.655WT1, REST, BRCA2, GPC3, POU6F2
regulation of nitrogen compound metabolic process (GO:0051171) 1.365WT1, GPC3, BRCA2, REST, POU6F2
metabolic process (GO:0008152) 0.585WT1, REST, BRCA2, GPC3, POU6F2
regulation of RNA biosynthetic process (GO:2001141) 1.555WT1, REST, BRCA2, GPC3, POU6F2
primary metabolic process (GO:0044238) 0.695WT1, REST, BRCA2, GPC3, POU6F2
regulation of macromolecule metabolic process (GO:0060255) 1.085WT1, REST, BRCA2, GPC3, POU6F2
regulation of RNA metabolic process (GO:0051252) 1.525WT1, GPC3, BRCA2, REST, POU6F2
cellular metabolic process (GO:0044237) 0.695WT1, REST, BRCA2, GPC3, POU6F2
macromolecule metabolic process (GO:0043170) 0.835WT1, GPC3, BRCA2, REST, POU6F2
regulation of transcription, DNA-templated (GO:0006355) 1.565WT1, REST, BRCA2, GPC3, POU6F2
regulation of macromolecule biosynthetic process (GO:0010556) 1.435WT1, GPC3, BRCA2, REST, POU6F2
developmental process (GO:0032502) 1.364WT1, GPC3, BRCA2, POU6F2
negative regulation of metabolic process (GO:0009892) 1.934WT1, GPC3, BRCA2, REST
positive regulation of metabolic process (GO:0009893) 1.744WT1, GPC3, BRCA2, REST
negative regulation of cellular metabolic process (GO:0031324) 2.014WT1, REST, BRCA2, GPC3
nucleic acid metabolic process (GO:0090304) 1.464WT1, REST, BRCA2, POU6F2
cellular biosynthetic process (GO:0044249) 1.374WT1, REST, BRCA2, POU6F2
cellular nitrogen compound metabolic process (GO:0034641) 1.224WT1, REST, BRCA2, POU6F2
cellular macromolecule biosynthetic process (GO:0034645) 1.664WT1, REST, BRCA2, POU6F2
organic cyclic compound biosynthetic process (GO:1901362) 1.664WT1, REST, BRCA2, POU6F2
organic cyclic compound metabolic process (GO:1901360) 1.264WT1, REST, BRCA2, POU6F2
nucleobase-containing compound metabolic process (GO:0006139) 1.354WT1, REST, BRCA2, POU6F2
negative regulation of macromolecule metabolic process (GO:0010605) 2.014WT1, REST, BRCA2, GPC3
positive regulation of macromolecule metabolic process (GO:0010604) 1.814WT1, REST, BRCA2, GPC3
cellular macromolecule metabolic process (GO:0044260) 0.934WT1, REST, BRCA2, POU6F2
positive regulation of biological process (GO:0048518) 1.24WT1, REST, BRCA2, GPC3
negative regulation of biological process (GO:0048519) 1.334WT1, GPC3, BRCA2, REST
heterocycle biosynthetic process (GO:0018130) 1.74WT1, REST, BRCA2, POU6F2
regulation of cell proliferation (GO:0042127) 2.414WT1, GPC3, BRCA2, REST
negative regulation of cell proliferation (GO:0008285) 3.264WT1, GPC3, BRCA2, REST
multicellular organismal process (GO:0032501) 1.454WT1, GPC3, BRCA2, POU6F2
regulation of developmental process (GO:0050793) 2.14WT1, GPC3, BRCA2, REST
cellular aromatic compound metabolic process (GO:0006725) 1.34WT1, REST, BRCA2, POU6F2
single-organism developmental process (GO:0044767) 1.494WT1, GPC3, BRCA2, POU6F2
regulation of multicellular organismal process (GO:0051239) 1.874WT1, REST, BRCA2, GPC3
nucleobase-containing compound biosynthetic process (GO:0034654) 1.724WT1, REST, BRCA2, POU6F2
heterocycle metabolic process (GO:0046483) 1.314WT1, REST, BRCA2, POU6F2
cellular nitrogen compound biosynthetic process (GO:0044271) 1.594WT1, REST, BRCA2, POU6F2
single-multicellular organism process (GO:0044707) 1.784WT1, GPC3, BRCA2, POU6F2
anatomical structure development (GO:0048856) 1.584WT1, GPC3, BRCA2, POU6F2
regulation of multicellular organismal development (GO:2000026) 2.314WT1, GPC3, BRCA2, REST
aromatic compound biosynthetic process (GO:0019438) 1.74WT1, REST, BRCA2, POU6F2
negative regulation of cellular process (GO:0048523) 1.414WT1, REST, BRCA2, GPC3
positive regulation of cellular process (GO:0048522) 1.34WT1, GPC3, BRCA2, REST
RNA biosynthetic process (GO:0032774) 1.843WT1, REST, POU6F2
negative regulation of biosynthetic process (GO:0009890) 2.473WT1, REST, BRCA2
positive regulation of biosynthetic process (GO:0009891) 2.293WT1, REST, BRCA2
negative regulation of cellular biosynthetic process (GO:0031327) 2.493WT1, REST, BRCA2
positive regulation of cellular metabolic process (GO:0031325) 1.813WT1, REST, BRCA2
cell differentiation (GO:0030154) 2.143WT1, GPC3, REST
positive regulation of gene expression (GO:0010628) 2.353WT1, REST, BRCA2
positive regulation of cellular biosynthetic process (GO:0031328) 2.33WT1, REST, BRCA2
nucleic acid-templated transcription (GO:0097659) 1.913WT1, REST, POU6F2
cellular response to stimulus (GO:0051716) 1.973WT1, REST, BRCA2
cellular component organization or biogenesis (GO:0071840) 1.223WT1, REST, BRCA2
negative regulation of multicellular organismal process (GO:0051241) 2.843WT1, REST, BRCA2
regulation of protein metabolic process (GO:0051246) 1.933WT1, GPC3, REST
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.63WT1, REST, BRCA2
cellular component organization (GO:0016043) 1.243WT1, REST, BRCA2
animal organ development (GO:0048513) 2.533WT1, GPC3, BRCA2
response to organic cyclic compound (GO:0014070) 3.073WT1, REST, BRCA2
transcription from RNA polymerase II promoter (GO:0006366) 3.383WT1, REST, POU6F2
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.563WT1, REST, BRCA2
negative regulation of developmental process (GO:0051093) 3.173WT1, REST, BRCA2
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.353WT1, REST, BRCA2
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.553WT1, REST, BRCA2
positive regulation of transcription, DNA-templated (GO:0045893) 2.563WT1, REST, BRCA2
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.473WT1, REST, BRCA2
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.293WT1, REST, BRCA2
response to chemical (GO:0042221) 1.983WT1, REST, BRCA2
response to organic substance (GO:0010033) 2.23WT1, REST, BRCA2
RNA metabolic process (GO:0016070) 1.593WT1, REST, POU6F2
regulation of cellular protein metabolic process (GO:0032268) 1.993WT1, GPC3, REST
response to stimulus (GO:0050896) 1.223WT1, REST, BRCA2
positive regulation of RNA metabolic process (GO:0051254) 2.513WT1, REST, BRCA2
positive regulation of RNA biosynthetic process (GO:1902680) 2.543WT1, REST, BRCA2
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.393WT1, REST, BRCA2
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.243WT1, GPC3, REST
transcription, DNA-templated (GO:0006351) 1.913WT1, REST, POU6F2
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.533WT1, REST, BRCA2
negative regulation of growth (GO:0045926) 4.242WT1, GPC3
regulation of anatomical structure morphogenesis (GO:0022603) 2.792WT1, GPC3
macromolecular complex subunit organization (GO:0043933) 2.142REST, BRCA2
regulation of transport (GO:0051049) 2.242GPC3, REST
cellular response to organic substance (GO:0071310) 2.782WT1, REST
cellular response to hormone stimulus (GO:0032870) 3.992WT1, REST
negative regulation of epithelial cell proliferation (GO:0050680) 4.982GPC3, BRCA2
branching morphogenesis of an epithelial tube (GO:0048754) 4.932WT1, GPC3
regulation of cellular component organization (GO:0051128) 2.012WT1, GPC3
negative regulation of signaling (GO:0023057) 2.652GPC3, REST
negative regulation of gene expression (GO:0010629) 2.482WT1, REST
morphogenesis of a branching structure (GO:0001763) 4.712WT1, GPC3
morphogenesis of a branching epithelium (GO:0061138) 4.772WT1, GPC3
cellular response to chemical stimulus (GO:0070887) 2.572WT1, REST
regulation of signaling (GO:0023051) 1.722GPC3, REST
positive regulation of cell death (GO:0010942) 3.322WT1, REST
reproductive structure development (GO:0048608) 4.082WT1, BRCA2
anatomical structure morphogenesis (GO:0009653) 2.532WT1, GPC3
regulation of apoptotic process (GO:0042981) 2.52WT1, REST
multicellular organism development (GO:0007275) 2.542BRCA2, POU6F2
response to endogenous stimulus (GO:0009719) 2.792WT1, REST
cellular protein metabolic process (GO:0044267) 1.632REST, BRCA2
negative regulation of protein metabolic process (GO:0051248) 2.822WT1, GPC3
regulation of localization (GO:0032879) 1.942GPC3, REST
regulation of cell communication (GO:0010646) 1.732GPC3, REST
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122WT1, REST
chromatin organization (GO:0006325) 3.282REST, BRCA2
response to lipid (GO:0033993) 3.112REST, BRCA2
regulation of growth (GO:0040008) 3.262WT1, GPC3
regulation of peptidase activity (GO:0052547) 3.752GPC3, REST
gonad development (GO:0008406) 4.922WT1, BRCA2
positive regulation of protein metabolic process (GO:0051247) 2.432GPC3, REST
positive regulation of apoptotic process (GO:0043065) 3.382WT1, REST
regulation of programmed cell death (GO:0043067) 2.492WT1, REST
histone modification (GO:0016570) 3.912REST, BRCA2
tissue morphogenesis (GO:0048729) 3.872WT1, GPC3
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.812WT1, REST
regulation of molecular function (GO:0065009) 1.782GPC3, REST
regulation of biological quality (GO:0065008) 1.682REST, BRCA2
positive regulation of programmed cell death (GO:0043068) 3.382WT1, REST
cellular response to endogenous stimulus (GO:0071495) 3.332WT1, REST
regulation of hydrolase activity (GO:0051336) 2.532GPC3, REST
tube morphogenesis (GO:0035239) 4.352WT1, GPC3
cell proliferation (GO:0008283) 3.232GPC3, BRCA2
morphogenesis of an epithelium (GO:0002009) 4.082WT1, GPC3
regulation of catalytic activity (GO:0050790) 1.972GPC3, REST
tissue development (GO:0009888) 3.272WT1, GPC3
cellular protein modification process (GO:0006464) 1.792REST, BRCA2
regulation of vesicle-mediated transport (GO:0060627) 3.632GPC3, REST
negative regulation of RNA biosynthetic process (GO:1902679) 2.72WT1, REST
reproductive process (GO:0022414) 2.552WT1, BRCA2
macromolecule modification (GO:0043412) 1.732REST, BRCA2
regulation of proteolysis (GO:0030162) 3.22GPC3, REST
negative regulation of transcription, DNA-templated (GO:0045892) 2.752WT1, REST
pattern specification process (GO:0007389) 3.792WT1, GPC3
cellular process involved in reproduction in multicellular organism (GO:0022412) 4.32WT1, BRCA2
branching involved in ureteric bud morphogenesis (GO:0001658) 5.972WT1, GPC3
establishment of localization (GO:0051234) 1.482REST, BRCA2
localization (GO:0051179) 1.42REST, BRCA2
response to oxygen-containing compound (GO:1901700) 2.572WT1, BRCA2
response to abiotic stimulus (GO:0009628) 2.82REST, BRCA2
negative regulation of cellular protein metabolic process (GO:0032269) 2.882WT1, GPC3
single organism reproductive process (GO:0044702) 2.732WT1, BRCA2
regulation of epithelial cell proliferation (GO:0050678) 4.062GPC3, BRCA2
developmental process involved in reproduction (GO:0003006) 3.362WT1, BRCA2
protein metabolic process (GO:0019538) 1.452REST, BRCA2
cellular response to organic cyclic compound (GO:0071407) 3.932WT1, REST
negative regulation of RNA metabolic process (GO:0051253) 2.662WT1, REST
regulation of cell death (GO:0010941) 2.432WT1, REST
kidney development (GO:0001822) 4.792WT1, GPC3
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712WT1, REST
protein modification process (GO:0036211) 1.792REST, BRCA2
negative regulation of cell communication (GO:0010648) 2.662GPC3, REST
regulation of organ morphogenesis (GO:2000027) 4.222WT1, GPC3
response to hormone (GO:0009725) 3.332WT1, REST
system development (GO:0048731) 2.922WT1, POU6F2
gland development (GO:0048732) 4.152WT1, BRCA2
covalent chromatin modification (GO:0016569) 3.892REST, BRCA2

NET-GE enrichment

Term New enriched termICP valueGenes
branching involved in ureteric bud morphogenesis (GO:0001658) -5.970.035WT1, GPC3
cellular developmental process (GO:0048869) -1.820.02WT1, GPC3, BRCA2, REST, POU6F2
regulation of steroid hormone biosynthetic process (GO:0090030) NEW7.530.04WT1, REST
negative regulation of cell proliferation (GO:0008285) -3.260.003WT1, GPC3, BRCA2, REST
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.65WT1, REST, BRCA2, GPC3, POU6F2
cell part (GO:0044464) 0.115WT1, GPC3, BRCA2, REST, POU6F2
intracellular organelle (GO:0043229) 0.515WT1, GPC3, BRCA2, REST, POU6F2
intracellular part (GO:0044424) 0.285WT1, REST, BRCA2, GPC3, POU6F2
membrane-bounded organelle (GO:0043227) 0.475WT1, GPC3, BRCA2, REST, POU6F2
organelle (GO:0043226) 0.45WT1, GPC3, BRCA2, REST, POU6F2
intracellular organelle part (GO:0044446) 0.814WT1, GPC3, BRCA2, REST
nucleus (GO:0005634) 1.074WT1, REST, BRCA2, POU6F2
organelle part (GO:0044422) 0.794WT1, REST, BRCA2, GPC3
nucleoplasm (GO:0005654) 1.893WT1, REST, BRCA2
cytoplasmic part (GO:0044444) 0.823REST, BRCA2, GPC3
nuclear part (GO:0044428) 1.553WT1, REST, BRCA2
cytoplasm (GO:0005737) 1.012WT1, BRCA2
protein complex (GO:0043234) 1.512REST, BRCA2
macromolecular complex (GO:0032991) 1.352REST, BRCA2
vesicle (GO:0031982) 1.642GPC3, BRCA2
intracellular non-membrane-bounded organelle (GO:0043232) 1.762WT1, BRCA2
integral component of membrane (GO:0016021) 1.142GPC3, BRCA2
membrane (GO:0016020) 0.682GPC3, BRCA2
membrane-bounded vesicle (GO:0031988) 1.712GPC3, BRCA2
non-membrane-bounded organelle (GO:0043228) 1.762WT1, BRCA2
membrane part (GO:0044425) 0.952GPC3, BRCA2
chromosomal part (GO:0044427) 3.182REST, BRCA2
intrinsic component of membrane (GO:0031224) 1.132GPC3, BRCA2