Gene | Associated with INCLUSION BODY MYOPATHY/PAGET DISEASE/FRONTOTEMPORAL DEMENTIA in | Link to HGNC | Cytogenetic band | Number of associated diseases | Associated diseases |
---|---|---|---|---|---|
VCP | ClinVar, OMIM, HUMSAVAR | HGNC link | 9p13.3 | 3 | PS118220, PS105400, PS167320 |
HNRNPA1 | ClinVar, OMIM, HUMSAVAR | HGNC link | 12q13.13 | 2 | PS167320, PS105400 |
HNRNPA2B1 | ClinVar, OMIM, HUMSAVAR | HGNC link | 7p15.2 | 1 | PS167320 |
Download the disease annotation in CSV format
TF | associated to this disease | # regulated genes | Regulated genes | # regulated genes associated with this disease | Regulated genes associated with this disease |
---|---|---|---|---|---|
MYC | NO | 102 | CBFB, PRDX3, CHKA, ATF3, CDK4, PCNA, CEBPA, LDHA, DKK1, MTDH, TFAP4, HLA-G, CDC25A, UBE2C, HLA-B, GATA1, TP53, BAG2, PMAIP1, CDK6, WRN, PGK1, TFAM, IGK, JUNB, ZFP36, HNRNPA1, MYB, SART3, EBNA1BP2, TOP1MT, ST3GAL4, CD33, CCND2, PTBP1, CDCA7, RB1, CCNA2, HLA-C, CYP3A4, FMR1, TERT, NFE2, MME, NDRG1, HDAC2, BRD7, FASLG, CCNB1, TP73, RCC1, SFRP1, HLA-F, CFLAR, BCAT1, CD38, TFRC, CCND1, MTA1, KRAS, HNRNPA2B1, CDC34, ST3GAL3, HLA-A, FUT3, NOL7, FTH1P18, VEGFA, EP300, CDK2, ASS1, SURF1, CDC25C, IER3, ST3GAL1, FOXM1, HSPA4, XPO1, CAD, SHMT1, DDX18, IGF2BP1, BMI1, IPO7, BCL2, CXCR4, SRSF1, TLX1, PRODH, NBN, CDKN1A, IFNA1, TNFRSF10B, ID2, CCNE1, SURF2, HLA-E, CREBBP, MAPK1, IL6, EIF4E, ODC1 | 2 | HNRNPA2B1, HNRNPA1 |
regulated gene | associated to this disease | # TFs | TFs | # TFs associated with this disease | TFs associated with this disease |
---|---|---|---|---|---|
VCP | YES | 2 | PBX1, ELF2 | 0 | |
HNRNPA1 | YES | 1 | MYC | 0 | |
HNRNPA2B1 | YES | 2 | BRCA1, MYC | 0 |
Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)
Gene1 | Gene2 | Direct Interaction | Interaction mode | Number of shared interactors | Shared genes in interaction |
---|---|---|---|---|---|
VCP | HNRNPA1 | No | - | 3 | UBC, TARDBP, AKT1 |
VCP | HNRNPA2B1 | No | - | 3 | UBC, TARDBP, AKT1 |
HNRNPA1 | HNRNPA2B1 | Yes | binding | 105 | CDC40, TARDBP, HNRNPK, SNRPD2, SNRPD1, RBMX, SNRNP200, RNPS1, SNRPE, POLR2B, DHX9, SNRNP70, SNRPD3, SNRPB, POLR2L, AKT1, PRPF6, DHX38, SNRPB2, SF3A1, POLR2I, CLP1, POLR2A, PHF5A, SF3A3, POLR2G, SRSF4, PCF11, HNRNPD, PRPF8, PARP2, U2AF2, SF3B2, HNRNPL, HNRNPUL1, POLR2H, MAGOH, PTBP1, NCBP2, PCBP2, POLR2K, CPSF2, CPSF3, GTF2F2, SNRPG, DDX23, HNRNPA3, SF3A2, NUDT21, POLR2D, NCBP1, HNRNPM, UBC, EFTUD2, HNRNPR, U2AF1, CSTF3, POLR2J, POLR2F, SNRPA, SRSF6, POLR2C, GTF2F1, SRSF5, SRSF7, HNRNPF, CD2BP2, SUGP1, SRSF11, FUS, HNRNPA0, PRPF4, HNRNPU, CSTF1, SNRPF, SRSF2, NFX1, SRRM1, CSTF2, YBX1, DNAJC8, SF3B1, UPF3B, PAPOLA, SF3B5, SNRPA1, SRSF1, SNRNP40, SRSF9, PCBP1, RBM5, ALYREF, HNRNPH3, PARP1, PRMT1, SF3B3, CCAR1, HNRNPC, PABPN1, TXNL4A, SRSF3, HNRNPH1, CPSF7, POLR2E, NHP2L1 |
Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)
Gene1 | Gene2 | Direct Interaction | Complexes | Number of shared interactors | Shared genes in interaction |
---|---|---|---|---|---|
HNRNPA1 | HNRNPA2B1 | Yes | C complex spliceosome | 78 | HNRNPR, WDR83, CRNKL1, PABPC1, SNRPA1, PNN, HNRNPM, U2AF1, SF3B2, HNRNPK, FRG1, GPATCH1, SRRM1, PRPF4B, RBMX, SNRNP200, LSM2, RBM8A, SF3B1, SNRPF, SNW1, SYF2, DDX23, EIF4A3, SKIV2L2, PPIE, SNRPG, CDC5L, SLU7, SRRM2, SNRPD2, SNRPE, HNRNPU, RALY, SYNCRIP, SRSF1, AQR, TFIP11, SNRNP40, PPWD1, RBM22, PPIL3, DDX41, CWC27, CACTIN, PRPF8, PLRG1, SNRPD3, ISY1, SNRPD1, CDC40, HNRNPC, ALYREF, SART1, SF3A2, DDX5, XAB2, SNRPB, MAGOH, LSM3, PPIL1, SF3B3, DHX35, HNRNPA3, ZCCHC8, HNRNPF, PRPF6, PRPF19, CWC22, SF3A1, CWC15, SF3A3, DHX38, HNRNPH1, DHX8, SNRPB2, DGCR14, EFTUD2 |
Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)
Gene1 | Gene2 | Direct Interaction | Number of shared interactors | Shared genes in interaction |
---|---|---|---|---|
HNRNPA1 | HNRNPA2B1 | Yes | 6 | HNRNPL, PTBP1, HNRNPDL, HNRNPD, HNRNPH1, HNRNPH3 |
Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)
REACTOME term | REACTOME term ID | IC | Number of genes with the same term | Genes |
---|---|---|---|---|
Gene Expression | R-HSA-74160 | 2.72 | 2 | HNRNPA2B1, HNRNPA1 |
mRNA Splicing - Major Pathway | R-HSA-72163 | 6.15 | 2 | HNRNPA2B1, HNRNPA1 |
Processing of Capped Intron-Containing Pre-mRNA | R-HSA-72203 | 6.1 | 2 | HNRNPA2B1, HNRNPA1 |
mRNA Splicing | R-HSA-72172 | 6.15 | 2 | HNRNPA2B1, HNRNPA1 |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
DNA Repair (R-HSA-73894) | NEW | 5.8 | 0.001 | HNRNPA2B1, HNRNPA1, VCP |
mRNA Splicing - Major Pathway (R-HSA-72163) | - | 6.15 | 0.05 | HNRNPA2B1, HNRNPA1 |
Processing of Capped Intron-Containing Pre-mRNA (R-HSA-72203) | - | 6.1 | 0.012 | HNRNPA2B1, HNRNPA1 |
mRNA Splicing (R-HSA-72172) | - | 6.15 | 0.05 | HNRNPA2B1, HNRNPA1 |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
structure-specific DNA binding (GO:0043566) | NEW | 4.98 | 0.027 | HNRNPA2B1, HNRNPA1 |
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds (GO:0016810) | NEW | 4.76 | 0.001 | HNRNPA2B1, HNRNPA1, VCP |
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (GO:0016811) | NEW | 5.28 | 0.0 | HNRNPA2B1, HNRNPA1, VCP |
poly(A) RNA binding (GO:0044822) | - | 2.69 | 0.015 | HNRNPA2B1, HNRNPA1, VCP |
phosphatase binding (GO:0019902) | NEW | 4.63 | 0.002 | HNRNPA2B1, HNRNPA1, VCP |
RNA binding (GO:0003723) | - | 2.36 | 0.041 | HNRNPA2B1, HNRNPA1, VCP |
single-stranded DNA binding (GO:0003697) | - | 5.17 | 0.032 | HNRNPA2B1, HNRNPA1 |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
detection of biotic stimulus (GO:0009595) | NEW | 6.55 | 0.0 | HNRNPA2B1, HNRNPA1, VCP |
regulation of natural killer cell activation (GO:0032814) | NEW | 6.4 | 0.038 | HNRNPA2B1, HNRNPA1 |
cellular amide metabolic process (GO:0043603) | NEW | 3.23 | 0.005 | HNRNPA2B1, HNRNPA1, VCP |
detection of bacterium (GO:0016045) | NEW | 7.33 | 0.004 | HNRNPA2B1, HNRNPA1 |
regulation of inflammatory response (GO:0050727) | NEW | 4.03 | 0.041 | HNRNPA2B1, HNRNPA1, VCP |
detection of external biotic stimulus (GO:0098581) | NEW | 6.68 | 0.0 | HNRNPA2B1, HNRNPA1, VCP |
detection of other organism (GO:0098543) | NEW | 7.24 | 0.005 | HNRNPA2B1, HNRNPA1 |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
catalytic step 2 spliceosome (GO:0071013) | - | 5.32 | 0.003 | HNRNPA2B1, HNRNPA1 |
spliceosomal complex (GO:0005681) | - | 4.65 | 0.009 | HNRNPA2B1, HNRNPA1 |
ribonucleoprotein complex (GO:0030529) | - | 3.19 | 0.048 | HNRNPA2B1, HNRNPA1, VCP |