Disease table of COFFIN-SIRIS SYNDROME OMIM ID: PS135900

Gene-disease associations table

Gene	Associated with COFFIN-SIRIS SYNDROME in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
ARID1B	ClinVar, OMIM	HGNC link	6q25.3	2	PS156200, PS135900
ARID1A	ClinVar, OMIM	HGNC link	1p36.11	2	PS156200, PS135900
SMARCA4	ClinVar, OMIM, HUMSAVAR	HGNC link	19p13.2	3	PS156200, PS135900, PS609322
SMARCE1	ClinVar	HGNC link	17q21.2	3	607174, PS135900, PS156200
SMARCB1	ClinVar, OMIM, HUMSAVAR	HGNC link	22q11.23	4	PS156200, PS609322, PS135900, PS162091

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes
ARID1B	YES	1	IGH
ARID1A	YES	3	IGH, CDKN1A, SMAD3
SMARCA4	YES	9	CDKN1A, CCND1, CDH1, CD44, CAD, MECOM, CDKN2A, FOS, ABCG2
SMARCB1	YES	2	CD44, CDKN2A

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
SMARCB1	YES	1	PARP1	0
CDKN2A	NO	24	FOXM1, EAPP, ETS2, EZH2, DNMT3A, HDAC9, ZBTB7A, SP1, HDAC3, MTA1, DNMT1, TBX2, E2F1, SMARCB1, TBX3, ZNF148, HDAC1, HDAC4, ETS1, SMARCA1, TBX5, SMARCA4, SP3, JUNB	2	SMARCB1, SMARCA4
CD44	NO	12	SP1, SMARCA1, TWIST2, SMARCA4, HDAC1, SNAI2, TWIST1, IKBKB, HMGA1, CTNNB1, SMARCB1, MYCN	2	SMARCB1, SMARCA4
CDKN1A	NO	118	ABL1, TFAP4, TP53, MYF5, TCF3, HDAC9, PAX5, ZBTB2, LCOR, E2F3, ZBTB5, HSF1, ELL, TSC22D3, NCOA1, TAF1, RELA, MYOD1, STAT1, PTTG1, KLF16, ESR1, JUNB, MYCN, KAT2B, AR, BCL6, KLF10, EZH2, ARID1A, JUND, SP1, CEBPB, ZFHX3, ZNF300, EGR1, KLF4, AATF, HDAC7, HBP1, SMARCA4, ESR2, FOXP3, RARA, NELFCD, ING4, HDAC4, TBX2, IRF1, HDAC2, ETV6, SIRT2, MYOG, KLF6, TP73, SOX6, ATM, ERCC2, SMAD4, ETS2, NUPR1, PTMA, MLLT10, SMAD3, ETS1, CBX8, BRCA1, HIPK2, SIRT1, WT1, ZNF76, HDAC1, SMAD2, MLLT3, TFAP2A, EP300, FHL2, TP63, IRF9, EHMT2, TFAP2C, NFIX, RUNX3, RB1, HNF4A, NFIB, TAF5, SOX9, TBP, EAPP, ZBTB17, TAF4, REL, RELB, PML, SMAD7, NPM1, POU5F1, E2F1, TBX3, FOXG1, MYF6, NFIA, ATF2, PARP1, NFKB1, STAT3, GFI1, NR3C1, CREBBP, MTA1, JUN, KLF2, CDX2, SP3, MYC, PPARG, ING1	2	ARID1A, SMARCA4
IGH	NO	3	ARID1A, POU2AF1, ARID1B	2	ARID1A, ARID1B

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
ARID1B	ARID1A	Yes	19	SMARCC1, SMARCE1, BCL7C, BCL7B, SMARCA4, DPF3, BCL7A, SMARCD1, SMARCB1, SMARCA2, DPF2, SMARCD2, SMARCC2, SMAD2, SMARCD3, ACTL6A, CUL2, YAP1, SS18
ARID1B	SMARCA4	Yes	22	ACTL6A, ARID1A, SMARCD2, HIST2H2BE, BCL7A, DPF2, SMARCE1, SMARCC2, SMARCD3, SMARCA1, BCL7B, SMARCB1, PRMT5, BCL7C, SMAD2, EPAS1, SMARCD1, SMARCC1, SMARCA2, DPF3, CAND1, SS18
ARID1B	SMARCE1	Yes	17	SMARCC1, BCL7C, BCL7B, SMARCA4, DPF3, SMARCD1, SMARCB1, PRMT5, SMARCA2, CAND1, SMARCD2, SMARCC2, DPF2, SMARCD3, ARID1A, ACTL6A, SS18
ARID1B	SMARCB1	Yes	20	SMARCC1, SMARCD2, SMARCA2, SMARCD3, BCL7B, BCL7A, DPF3, SMARCD1, SMARCB1, PRMT5, BCL7C, DPF2, SMARCE1, SMARCC2, CAND1, SMARCA4, EPAS1, ARID1A, ACTL6A, SS18
ARID1A	SMARCA4	Yes	33	CDC5L, KLF1, TP53, DPF2, TAT, SMARCD2, ADNP, CARM1, BCL7A, PBRM1, SIRT7, SMARCE1, SMARCC2, SMAD3, SS18, SMARCD3, ACTL6A, PHF10, BCL7B, ARID1B, EED, SMARCB1, BCL7C, SMAD2, CHD7, GATA1, SMARCD1, SMARCC1, SMARCA2, DPF3, CUL3, ESR1, ING1
ARID1A	SMARCE1	Yes	31	RARB, KLF1, ESR1, PGR, EWSR1, NXF1, ARID1B, CARM1, DPF3, PBRM1, DPF2, SMARCD2, SMARCC2, SMARCD1, SMARCD3, TFAP4, PHF10, BCL7B, ITCH, ACTL6A, SMARCB1, BCL7C, CHD7, NCOA1, MOV10, SMARCC1, SMARCA2, CUL3, SMARCA4, GATA1, SS18
ARID1A	SMARCB1	Yes	28	KLF1, TP53, ACTL6A, TAT, SMARCE1, CARM1, BCL7A, PBRM1, DPF2, SMARCD2, SMARCC2, SMARCD3, TFAP4, PHF10, BCL7B, ARID1B, SMARCB1, BCL7C, SOX2, GATA1, SMARCD1, SMARCC1, SMARCA2, DPF3, SS18, SMARCA4, CUL3, ING1
SMARCA4	SMARCE1	Yes	52	AR, SIN3B, MDM2, KLF1, WWOX, REST, SS18, BRD7, SMARCAD1, ARID1A, HDAC1, ARID1B, RELB, HIST1H3E, CARM1, DPF3, CAND1, TOP2B, PBRM1, SMARCC2, DPF2, SMARCD2, BCL7C, SS18L1, NCOR1, DPF1, SMARCB1, PHF10, BCL7B, SMARCD3, ACTL6A, SIN3A, CHD4, PRMT5, SMARCA2, RNF2, CHD7, GATA1, ZMIZ2, STAT2, ARID2, RCOR1, SMARCC1, HMGB1, NR3C1, SMARCD1, HDAC2, ACTB, UL29, CUL3, ESR1, IKZF1
SMARCA4	SMARCB1	Yes	56	CHFR, KLF1, TP53, RPS6KA5, SS18, DPF2, SMARCAD1, TAT, HDAC1, ARID1A, NCOR1, SMARCD2, CARM1, DPF3, ARID1B, RUNX1, TOP2B, PBRM1, MCPH1, NONO, SMARCE1, CDK8, SMARCC2, COPS5, RELB, CDYL, BRCA1, ACTL6A, PHF10, SMARCD3, BCL7B, DPF1, HSF1, PRMT5, SMARCB1, SIN3A, BCL7C, NFATC1, GATA1, EPAS1, CCNE1, ARID2, SMARCD1, SMARCC1, SMARCA2, BCL7A, HDAC2, CAND1, CEBPB, POLR2A, SIN3B, CDX2, MYC, RBBP4, CUL3, ING1
SMARCE1	SMARCB1	Yes	40	SMARCAD1, KLF1, XPO1, TFAP4, ACTL6A, ARID1A, HDAC1, ARID1B, NCOR1, CARM1, DPF3, TOP2B, PBRM1, DPF2, SMARCD2, SMARCC2, RELB, DPF1, SS18, PHF10, BCL7B, SMARCD3, FOXN1, PRMT5, SMARCB1, SIN3A, BCL7C, JUN, GATA1, MECP2, ARID2, SMARCD1, SMARCC1, SMARCA2, NR0B2, HDAC2, CAND1, CUL3, SMARCA4, SIN3B

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
ARID1B	ARID1A	Yes	binding	16	SMARCC1, SMARCD2, SMARCA2, SMARCD3, DPF3, HELLS, ACTL6B, RB1, SMARCE1, SMARCC2, SMARCD1, DPF1, ACTL6A, SMARCA4, SMARCB1, PHF10
ARID1B	SMARCA4	Yes	activation, binding	15	SMARCC1, SMARCD2, SMARCA2, SMARCD3, DPF3, ACTL6B, RB1, SMARCE1, SMARCC2, SMARCD1, DPF1, ACTL6A, ARID1A, SMARCB1, PHF10
ARID1B	SMARCE1	Yes	binding	16	SMARCC1, SMARCA2, SMARCD3, DPF3, HELLS, ACTL6B, RB1, SMARCD2, SMARCC2, SMARCD1, DPF1, ACTL6A, SMARCA4, ARID1A, SMARCB1, PHF10
ARID1B	SMARCB1	Yes	binding	16	SMARCC1, SMARCD2, SMARCA2, SMARCD3, DPF3, HELLS, ACTL6B, RB1, SMARCE1, SMARCC2, SMARCD1, DPF1, ACTL6A, ARID1A, SMARCA4, PHF10
ARID1A	SMARCA4	Yes	activation, binding	42	KAT2B, IRF2, GTF2B, ACTL6A, IRF5, TP53, GTF2A1, ARID1B, TOP2B, SMARCD2, DPF3, PBRM1, POLR2A, IRF7, SMARCE1, SMARCC2, CHAF1A, ACTL6B, PHF10, GTF3A, SMARCD3, IFNB1, DPF1, GTF2E1, VDR, SMARCB1, SMARCA2, SUPT16H, JUN, ATF2, RELA, SMARCD1, SMARCC1, CREBBP, HMGB1, IRF4, NR3C1, IRF1, RB1, GTF2F1, IRF6, IRF3
ARID1A	SMARCE1	Yes	binding	42	KAT2B, IRF2, GTF2B, HELLS, ACTL6A, IRF5, GTF2A1, ARID1B, TOP2B, DPF3, PBRM1, POLR2A, IRF7, SMARCD2, SMARCC2, CHAF1A, ACTL6B, PHF10, GTF3A, SMARCD3, IFNB1, DPF1, GTF2E1, VDR, SMARCB1, SMARCA2, SUPT16H, JUN, ATF2, RELA, SMARCD1, SMARCC1, CREBBP, HMGB1, IRF4, NR3C1, IRF1, RB1, GTF2F1, SMARCA4, IRF6, IRF3
ARID1A	SMARCB1	Yes	binding	39	KAT2B, IRF2, GTF2B, HELLS, ACTL6A, IRF5, TP53, GTF2A1, SMARCD2, DPF3, PBRM1, POLR2A, IRF7, SMARCE1, SMARCC2, DPF1, PHF10, GTF3A, SMARCD3, IFNB1, ARID1B, GTF2E1, ACTL6B, SMARCA2, ATF2, JUN, RELA, SMARCD1, SMARCC1, CREBBP, HMGB1, IRF4, NR3C1, IRF1, RB1, GTF2F1, SMARCA4, IRF6, IRF3
SMARCA4	SMARCE1	Yes	activation, binding	53	KAT2B, AR, IRF4, GTF2B, ACTL6A, IRF2, IRF5, IRF7, GTF2A1, ARID1A, ARID1B, TOP2B, CARM1, ESR2, DPF3, PBRM1, SMARCC2, DPF2, SMARCD2, ZNF14, GTF2F1, SMARCD3, SMARCB1, PHF10, BANF1, GTF3A, IFNB1, CHAF1A, GTF2E1, VDR, CHD4, ACTL6B, SMARCA2, SUPT16H, JUN, ATF2, RELA, ZMIZ2, ARID2, SMARCD1, SMARCC1, CREBBP, HMGB1, POLR2A, NR3C1, IRF1, RB1, IRF3, ESR1, UBC, IRF6, MYOG, DPF1
SMARCA4	SMARCB1	Yes	activation, binding	63	KAT2B, KAT2A, IRF5, GTF2B, SMARCC2, KLF1, IRF2, TP53, GTF2A1, GTF3A, ARID1A, XPC, PHF7, YEATS4, SMARCD2, RAD52, ESR2, DPF3, CCND1, PBRM1, POLR2A, IRF7, SMARCE1, ZNF14, DPF1, BRCA1, ACTL6A, PHF10, SMARCC1, CDKN1A, IFNB1, SMARCD3, GTF2E1, ACTL6B, HDAC1, SIN3A, SMARCA2, ATF2, UBC, JUN, ARID1B, RELA, ASH1L, ARID2, MYC, SMARCD1, SMARCA1, CREBBP, HMGB1, IRF4, NR3C1, RBBP4, IRF6, HDAC2, MYSM1, CEBPB, RB1, GTF2F1, PHF11, JUNB, MLLT1, IRF1, IRF3
SMARCE1	SMARCB1	Yes	binding	42	KAT2B, IRF2, IRF4, GTF2B, HELLS, ACTL6A, IRF5, GTF2A1, ARID1A, ESR2, DPF3, PBRM1, SMARCC2, IRF7, SMARCD2, ZNF14, DPF1, PHF10, GTF3A, SMARCD3, IFNB1, ARID1B, GTF2E1, ACTL6B, SMARCA2, ATF2, JUN, RELA, ARID2, SMARCD1, SMARCC1, CREBBP, HMGB1, POLR2A, NR3C1, IRF1, RB1, GTF2F1, SMARCA4, UBC, IRF6, IRF3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
ARID1B	ARID1A	Yes	BAF complex;SWI-SNF chromatin remodeling-related-BRCA1 complex	15	SMARCC1, SMARCD2, SMARCA2, ACTL6A, SMARCB1, ACTG1, ACTB, SMARCE1, SMARCC2, SMARCA4, CREBBP, BRCA1, MLLT1, ACTL6B, SMARCD1
ARID1B	SMARCA4	Yes	BAF complex;SWI-SNF chromatin remodeling-related-BRCA1 complex	20	SMARCC1, ACTL6B, TRIM33, NCOA3, SMARCB1, SMARCA2, ACTG1, ACTB, SMAD4, SMARCE1, SMARCC2, SMAD3, SMAD2, ACTL6A, CREBBP, ARID1A, MLLT1, BRCA1, SMARCD1, SMARCD2
ARID1B	SMARCE1	Yes	EBAFb complex	14	SMARCC1, ACTL6B, SMARCA2, ACTL6A, SMARCB1, ACTG1, ACTB, SMARCD2, SMARCC2, SMARCA4, BRCA1, MLLT1, ARID1A, SMARCD1
ARID1B	SMARCB1	Yes	BAF complex;SWI-SNF chromatin remodeling-related-BRCA1 complex	15	SMARCC1, SMARCD2, SMARCA2, ACTL6A, ACTL6B, ACTG1, ACTB, SMARCE1, SMARCC2, SMARCA4, CREBBP, BRCA1, MLLT1, ARID1A, SMARCD1
ARID1A	SMARCA4	Yes	BAF complex;SWI-SNF chromatin remodeling-related-BRCA1 complex	41	MBD2, HDAC2, ACTL6A, SMARCB1, SAP30, PRMT5, RBBP7, TOP2B, SMARCD2, CARM1, MBD3, SMARCA2, DPF2, SMARCE1, SMARCC2, CHAF1A, BAZ1B, BRCA1, HDAC1, ACTL6B, SMARCD3, VDR, SIN3A, CHD4, ACTG1, ARID4B, SUPT16H, ACTB, MTA2, EP300, SMARCD1, SMARCC1, HNRNPC, RBBP4, CREBBP, SCYL1, GATAD2B, ARID1B, SAP18, MLLT1, ING1
ARID1A	SMARCE1	Yes	BAF complex;SWI-SNF chromatin remodeling-related-BRCA1 complex	34	MBD2, HDAC2, ACTL6A, SMARCB1, TOP2B, CHD4, CARM1, SIN3A, DPF2, SMARCD2, SMARCC2, CHAF1A, BAZ1B, BRCA1, HDAC1, SMARCD3, VDR, PRMT5, ACTL6B, ACTG1, HNRNPC, SUPT16H, ACTB, MTA2, SMARCD1, SMARCC1, SMARCA2, RBBP4, SCYL1, GATAD2B, MBD3, SMARCA4, MLLT1, ARID1B
ARID1A	SMARCB1	Yes	BAF complex;SWI-SNF chromatin remodeling-related-BRCA1 complex	41	HNRNPC, MBD2, HDAC2, ACTL6A, SAP30, PRMT5, RBBP7, TOP2B, SMARCD2, CARM1, MBD3, DPF2, SMARCE1, SMARCC2, CHAF1A, BAZ1B, BRCA1, HDAC1, ACTL6B, SMARCD3, SMARCA4, VDR, SIN3A, CHD4, ACTG1, SMARCA2, SUPT16H, ACTB, MTA2, EP300, SMARCD1, SMARCC1, ARID4B, RBBP4, CREBBP, SCYL1, GATAD2B, ARID1B, SAP18, MLLT1, ING1
SMARCA4	SMARCE1	Yes	BAF complex	39	MBD2, HDAC2, ACTL6A, SMARCB1, PRMT5, GATAD2B, ARID1A, TOP2B, CHD4, CARM1, PBRM1, CCNC, DPF2, SMARCD2, SMARCC2, CHAF1A, BAZ1B, BRCA1, HDAC1, SMARCD3, VDR, SIN3A, ACTL6B, ACTG1, HNRNPC, SUPT16H, ACTB, MTA2, ARID2, SMARCD1, SMARCC1, SMARCA2, RBBP4, SCYL1, CDK8, MED21, MBD3, MLLT1, ARID1B
SMARCA4	SMARCB1	Yes	SWI-SNF chromatin remodeling-related-BRCA1 complex;EBAFa complex;PBAF complex (Polybromo- and BAF containing complex);NUMAC complex (nucleosomal methylation activator complex);SIN3-ING1b complex II;WINAC complex;ETS2-SMARCA4-INI1 complex;EBAFb complex;RNA polymerase II complex, chromatin structure modifying;Brg1-associated complex I;BRG1-associated complex;Brg1-associated complex II;BRG1-SIN3A complex;NCOR1 complex;BAF complex;p300-CBP-p270-SWI/SNF complex;BRG1-SIN3A-HDAC containing SWI/SNF remodeling complex I;LARC complex (LCR-associated remodeling complex)	64	KAT2B, HNRNPC, MBD2, GTF2B, RBBP4, TBP, HDAC2, ACTL6A, TRIM28, ETS2, ING1, PRMT5, RBBP7, ARID1A, NCOR1, SMARCD2, CARM1, CCNC, ARID2, GTF2H1, PBRM1, SMARCC2, DPF2, SMARCE1, CDK8, HDAC3, TOP2B, CHAF1A, BAZ1B, BRCA1, HDAC1, GTF2F1, MBD3, ACTL6B, SMARCD3, ARID1B, GTF2E1, VDR, SIN3A, CHD4, ACTG1, ARID4B, SUPT16H, DRAP1, SAP30, MTA2, ERCC3, SRCAP, SF3B3, SMARCC1, SMARCA2, EP300, POLR2A, SF3A1, SMARCD1, CREBBP, SCYL1, ACTB, GATAD2B, MED21, PCSK4, SAP18, MLLT1, GTF2H3
SMARCE1	SMARCB1	Yes	SWI-SNF chromatin remodeling-related-BRCA1 complex;EBAFa complex;PBAF complex (Polybromo- and BAF containing complex);NUMAC complex (nucleosomal methylation activator complex);WINAC complex;BRM-associated complex;EBAFb complex;RNA polymerase II complex, chromatin structure modifying;Brm-associated complex;Brg1-associated complex I;BRG1-associated complex;BRG1-SIN3A complex;BRM-SIN3A complex;BAF complex;BRM-SIN3A-HDAC complex;BRG1-SIN3A-HDAC containing SWI/SNF remodeling complex I;LARC complex (LCR-associated remodeling complex)	39	MBD2, HDAC2, ACTL6A, PRMT5, GATAD2B, ARID1A, TOP2B, CHD4, CARM1, PBRM1, CCNC, DPF2, SMARCD2, SMARCC2, CHAF1A, BAZ1B, BRCA1, ACTL6B, SMARCD3, VDR, SIN3A, HDAC1, ACTG1, HNRNPC, SUPT16H, ACTB, MTA2, ARID2, SMARCD1, SMARCC1, SMARCA2, RBBP4, SCYL1, CDK8, MED21, MBD3, SMARCA4, MLLT1, ARID1B

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
ARID1B	ARID1A	Yes	8	SMARCC1, SMARCA2, SMARCB1, SMARCE1, SMARCC2, SMARCA4, ACTL6A, SMARCD1
ARID1B	SMARCA4	Yes	8	SMARCC1, SMARCA2, SMARCB1, SMARCE1, SMARCC2, ARID1A, ACTL6A, SMARCD1
ARID1B	SMARCE1	Yes	8	SMARCC1, SMARCA2, ACTL6A, SMARCC2, SMARCA4, ARID1A, SMARCB1, SMARCD1
ARID1B	SMARCB1	Yes	7	SMARCC1, SMARCA2, SMARCE1, SMARCC2, SMARCA4, ARID1A, SMARCD1
ARID1A	SMARCA4	Yes	11	SMARCC1, SMARCD2, SMARCA2, SMARCD1, SMARCB1, SMARCE1, SMARCC2, PHF10, SMARCD3, ACTL6A, ARID1B
ARID1A	SMARCE1	Yes	11	SMARCC1, SMARCA2, SMARCD1, SMARCA4, SMARCB1, SMARCD2, SMARCC2, PHF10, SMARCD3, ACTL6A, ARID1B
ARID1A	SMARCB1	Yes	10	SMARCC1, SMARCE1, SMARCA2, SMARCD1, SMARCA4, SMARCD2, SMARCC2, PHF10, SMARCD3, ARID1B
SMARCA4	SMARCE1	Yes	12	SMARCC1, SMARCA2, SMARCB1, TOP2B, PHF10, SMARCD2, SMARCC2, SMARCD1, SMARCD3, ARID1A, ACTL6A, ARID1B
SMARCA4	SMARCB1	Yes	11	SMARCC1, SMARCE1, SMARCA2, SMARCD1, TOP2B, SMARCD2, SMARCC2, PHF10, SMARCD3, ARID1A, ARID1B
SMARCE1	SMARCB1	Yes	12	SMARCC1, SMARCA2, SMARCD1, SMARCD3, PHF10, SMARCD2, SMARCC2, ARID1B, DPF1, ARID1A, SMARCA4, TOP2B

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
RMTs methylate histone arginines	R-HSA-3214858	7.49	5	SMARCE1, SMARCB1, ARID1B, ARID1A, SMARCA4
Chromatin organization	R-HSA-4839726	5.19	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
Chromatin modifying enzymes	R-HSA-3247509	5.19	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B

NET-GE enrichment

Term	New enriched term	IC	Genes
RMTs methylate histone arginines (R-HSA-3214858)	-	7.49	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
Chromatin organization (R-HSA-4839726)	-	5.19	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
Chromatin modifying enzymes (R-HSA-3247509)	-	5.19	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
transcription factor activity, transcription factor binding (GO:0000989)	3.36	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
protein binding (GO:0005515)	0.46	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
organic cyclic compound binding (GO:0097159)	1.05	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
transcription factor activity, protein binding (GO:0000988)	3.35	5	SMARCE1, SMARCB1, ARID1B, ARID1A, SMARCA4
transcription coactivator activity (GO:0003713)	4.04	5	SMARCE1, SMARCB1, ARID1B, ARID1A, SMARCA4
transcription cofactor activity (GO:0003712)	3.44	5	SMARCE1, SMARCB1, SMARCA4, ARID1B, ARID1A
binding (GO:0005488)	0.18	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
nucleic acid binding (GO:0003676)	1.44	5	SMARCE1, SMARCB1, ARID1B, ARID1A, SMARCA4
DNA binding (GO:0003677)	1.92	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
heterocyclic compound binding (GO:1901363)	1.06	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
nucleosome binding (GO:0031491)	5.95	4	SMARCE1, ARID1A, SMARCB1, SMARCA4
protein complex binding (GO:0032403)	3.09	4	SMARCE1, SMARCB1, ARID1A, SMARCA4
chromatin binding (GO:0003682)	3.64	4	SMARCE1, SMARCB1, ARID1A, SMARCA4
macromolecular complex binding (GO:0044877)	2.61	4	SMARCE1, SMARCB1, ARID1A, SMARCA4
transcription regulatory region DNA binding (GO:0044212)	3.03	3	SMARCE1, SMARCB1, SMARCA4
structure-specific DNA binding (GO:0043566)	4.98	3	SMARCE1, SMARCB1, SMARCA4
sequence-specific double-stranded DNA binding (GO:1990837)	3.2	3	SMARCE1, SMARCB1, SMARCA4
enhancer binding (GO:0035326)	5.21	3	SMARCE1, SMARCB1, SMARCA4
sequence-specific DNA binding (GO:0043565)	2.79	3	SMARCE1, SMARCB1, SMARCA4
regulatory region nucleic acid binding (GO:0001067)	3.03	3	SMARCE1, SMARCB1, SMARCA4
RNA polymerase II regulatory region DNA binding (GO:0001012)	3.36	3	SMARCE1, SMARCB1, SMARCA4
receptor binding (GO:0005102)	2.43	3	SMARCE1, ARID1A, SMARCA4
core promoter proximal region DNA binding (GO:0001159)	3.82	3	SMARCE1, SMARCB1, SMARCA4
enhancer sequence-specific DNA binding (GO:0001158)	5.36	3	SMARCE1, SMARCB1, SMARCA4
chromatin DNA binding (GO:0031490)	5.37	3	SMARCE1, SMARCB1, SMARCA4
nucleosomal DNA binding (GO:0031492)	6.37	3	SMARCE1, SMARCB1, SMARCA4
transcription regulatory region sequence-specific DNA binding (GO:0000976)	3.24	3	SMARCE1, SMARCB1, SMARCA4
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)	3.37	3	SMARCE1, SMARCB1, SMARCA4
regulatory region DNA binding (GO:0000975)	3.03	3	SMARCE1, SMARCB1, SMARCA4
core promoter proximal region sequence-specific DNA binding (GO:0000987)	3.83	3	SMARCE1, SMARCB1, SMARCA4
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978)	3.88	3	SMARCE1, SMARCB1, SMARCA4
double-stranded DNA binding (GO:0003690)	3.09	3	SMARCE1, SMARCB1, SMARCA4
RNA polymerase II distal enhancer sequence-specific DNA binding (GO:0000980)	5.58	3	SMARCE1, SMARCB1, SMARCA4
Tat protein binding (GO:0030957)	7.66	2	SMARCB1, SMARCA4
protein N-terminus binding (GO:0047485)	5.11	2	SMARCE1, SMARCA4
p53 binding (GO:0002039)	5.53	2	SMARCB1, SMARCA4
transcription factor binding (GO:0008134)	3.46	2	SMARCB1, SMARCA4
RNA polymerase I regulatory region DNA binding (GO:0001013)	7.54	2	SMARCB1, SMARCA4
RNA polymerase I regulatory region sequence-specific DNA binding (GO:0001163)	7.66	2	SMARCB1, SMARCA4
catalytic activity (GO:0003824)	1.05	2	SMARCE1, SMARCA4
core promoter binding (GO:0001047)	4.71	2	SMARCB1, SMARCA4
core promoter sequence-specific DNA binding (GO:0001046)	5.12	2	SMARCB1, SMARCA4
ligand-dependent nuclear receptor binding (GO:0016922)	6.6	2	SMARCE1, ARID1A
RNA polymerase I CORE element sequence-specific DNA binding (GO:0001164)	7.66	2	SMARCB1, SMARCA4

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Tat protein binding (GO:0030957)	-	7.66	0.0	SMARCB1, SMARCA4
chromatin binding (GO:0003682)	-	3.64	0.014	SMARCE1, ARID1A, SMARCB1, SMARCA4
protein N-terminus binding (GO:0047485)	-	5.11	0.015	SMARCE1, SMARCA4
ligand-dependent nuclear receptor binding (GO:0016922)	-	6.6	0.0	SMARCE1, ARID1A, SMARCA4
histone acetyltransferase activity (GO:0004402)	NEW	5.7	0.021	SMARCE1, SMARCA4
transcription cofactor activity (GO:0003712)	-	3.44	0.001	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
transcription factor binding transcription factor activity (GO:0000989)	-	3.36	0.001	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
protein binding transcription factor activity (GO:0000988)	-	3.35	0.0	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
p53 binding (GO:0002039)	-	5.53	0.006	SMARCB1, SMARCA4
transcription coactivator activity (GO:0003713)	-	4.04	0.0	SMARCE1, SMARCB1, ARID1B, ARID1A, SMARCA4

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
anatomical structure development (GO:0048856)	1.58	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
regulation of primary metabolic process (GO:0080090)	1.08	5	SMARCE1, ARID1A, ARID1B, SMARCB1, SMARCA4
regulation of metabolic process (GO:0019222)	1.02	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
macromolecular complex subunit organization (GO:0043933)	2.14	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
regulation of cellular biosynthetic process (GO:0031326)	1.38	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
regulation of cellular metabolic process (GO:0031323)	1.07	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
regulation of biological process (GO:0050789)	0.45	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
cellular component organization or biogenesis (GO:0071840)	1.22	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
chromatin organization (GO:0006325)	3.28	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
cellular component organization (GO:0016043)	1.24	5	SMARCE1, ARID1A, ARID1B, SMARCB1, SMARCA4
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	5	SMARCE1, ARID1A, ARID1B, SMARCB1, SMARCA4
biological regulation (GO:0065007)	0.39	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
regulation of gene expression (GO:0010468)	1.37	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
developmental process (GO:0032502)	1.36	5	SMARCE1, ARID1A, ARID1B, SMARCB1, SMARCA4
regulation of macromolecule metabolic process (GO:0060255)	1.08	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
cellular process (GO:0009987)	0.26	5	SMARCE1, ARID1A, ARID1B, SMARCB1, SMARCA4
regulation of biosynthetic process (GO:0009889)	1.37	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
regulation of cellular process (GO:0050794)	0.5	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
regulation of RNA biosynthetic process (GO:2001141)	1.55	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
nervous system development (GO:0007399)	3.53	5	SMARCE1, ARID1A, ARID1B, SMARCB1, SMARCA4
chromatin remodeling (GO:0006338)	4.78	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
regulation of RNA metabolic process (GO:0051252)	1.52	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
regulation of transcription, DNA-templated (GO:0006355)	1.56	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
system development (GO:0048731)	2.92	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
chromatin modification (GO:0016568)	4.06	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
nucleosome organization (GO:0034728)	4.79	4	SMARCE1, SMARCB1, ARID1A, SMARCA4
negative regulation of metabolic process (GO:0009892)	1.93	4	SMARCE1, SMARCB1, ARID1A, SMARCA4
positive regulation of metabolic process (GO:0009893)	1.74	4	ARID1A, SMARCB1, SMARCA4, ARID1B
positive regulation of biosynthetic process (GO:0009891)	2.29	4	ARID1A, SMARCB1, SMARCA4, ARID1B
positive regulation of cellular metabolic process (GO:0031325)	1.81	4	ARID1A, SMARCB1, SMARCA4, ARID1B
negative regulation of cellular metabolic process (GO:0031324)	2.01	4	SMARCE1, SMARCB1, ARID1A, SMARCA4
nucleic acid metabolic process (GO:0090304)	1.46	4	ARID1A, SMARCB1, SMARCA4, ARID1B
cellular biosynthetic process (GO:0044249)	1.37	4	ARID1A, SMARCB1, SMARCA4, ARID1B
cellular nitrogen compound metabolic process (GO:0034641)	1.22	4	ARID1A, ARID1B, SMARCB1, SMARCA4
nitrogen compound metabolic process (GO:0006807)	1.13	4	ARID1A, ARID1B, SMARCB1, SMARCA4
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	4	ARID1A, SMARCB1, SMARCA4, ARID1B
cellular macromolecule biosynthetic process (GO:0034645)	1.66	4	ARID1A, ARID1B, SMARCB1, SMARCA4
organic cyclic compound biosynthetic process (GO:1901362)	1.66	4	ARID1A, ARID1B, SMARCB1, SMARCA4
organic cyclic compound metabolic process (GO:1901360)	1.26	4	ARID1A, ARID1B, SMARCB1, SMARCA4
RNA biosynthetic process (GO:0032774)	1.84	4	ARID1A, SMARCB1, SMARCA4, ARID1B
protein-DNA complex subunit organization (GO:0071824)	4.45	4	SMARCE1, SMARCB1, ARID1A, SMARCA4
organic substance biosynthetic process (GO:1901576)	1.34	4	ARID1A, SMARCB1, SMARCA4, ARID1B
macromolecular complex disassembly (GO:0032984)	4.53	4	SMARCE1, ARID1A, SMARCB1, SMARCA4
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	4	SMARCE1, ARID1A, SMARCB1, SMARCA4
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	4	ARID1A, ARID1B, SMARCB1, SMARCA4
cellular macromolecule metabolic process (GO:0044260)	0.93	4	ARID1A, SMARCB1, SMARCA4, ARID1B
cellular developmental process (GO:0048869)	1.82	4	SMARCE1, ARID1A, SMARCB1, SMARCA4
ATP-dependent chromatin remodeling (GO:0043044)	5.6	4	SMARCE1, ARID1A, SMARCB1, SMARCA4
organic substance metabolic process (GO:0071704)	0.63	4	ARID1A, SMARCB1, SMARCA4, ARID1B
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	4	SMARCE1, SMARCB1, ARID1A, SMARCA4
nucleic acid-templated transcription (GO:0097659)	1.91	4	ARID1A, SMARCB1, SMARCA4, ARID1B
positive regulation of biological process (GO:0048518)	1.2	4	ARID1A, ARID1B, SMARCB1, SMARCA4
negative regulation of biological process (GO:0048519)	1.33	4	SMARCE1, SMARCB1, ARID1A, SMARCA4
protein complex disassembly (GO:0043241)	4.58	4	SMARCE1, ARID1A, SMARCB1, SMARCA4
heterocycle biosynthetic process (GO:0018130)	1.7	4	ARID1A, SMARCB1, SMARCA4, ARID1B
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	4	SMARCB1, ARID1B, ARID1A, SMARCA4
protein-DNA complex disassembly (GO:0032986)	6.9	4	SMARCE1, ARID1A, SMARCB1, SMARCA4
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	4	ARID1A, SMARCB1, SMARCA4, ARID1B
nucleobase-containing compound metabolic process (GO:0006139)	1.35	4	ARID1A, SMARCB1, SMARCA4, ARID1B
cellular aromatic compound metabolic process (GO:0006725)	1.3	4	ARID1A, SMARCB1, SMARCA4, ARID1B
biosynthetic process (GO:0009058)	1.32	4	ARID1A, SMARCB1, SMARCA4, ARID1B
macromolecule biosynthetic process (GO:0009059)	1.61	4	ARID1A, SMARCB1, SMARCA4, ARID1B
single-organism cellular process (GO:0044763)	0.65	4	SMARCE1, ARID1A, SMARCB1, SMARCA4
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	4	ARID1A, SMARCB1, SMARCA4, ARID1B
metabolic process (GO:0008152)	0.58	4	ARID1A, ARID1B, SMARCB1, SMARCA4
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	4	ARID1A, SMARCB1, SMARCA4, ARID1B
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	4	ARID1A, SMARCB1, SMARCA4, ARID1B
heterocycle metabolic process (GO:0046483)	1.31	4	ARID1A, SMARCB1, SMARCA4, ARID1B
RNA metabolic process (GO:0016070)	1.59	4	ARID1A, SMARCB1, SMARCA4, ARID1B
primary metabolic process (GO:0044238)	0.69	4	ARID1A, ARID1B, SMARCB1, SMARCA4
single-organism process (GO:0044699)	0.48	4	SMARCE1, SMARCB1, ARID1A, SMARCA4
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	4	ARID1A, ARID1B, SMARCB1, SMARCA4
protein complex subunit organization (GO:0071822)	2.6	4	SMARCE1, SMARCB1, ARID1A, SMARCA4
nucleosome disassembly (GO:0006337)	6.9	4	SMARCE1, SMARCB1, ARID1A, SMARCA4
positive regulation of RNA metabolic process (GO:0051254)	2.51	4	ARID1A, SMARCB1, SMARCA4, ARID1B
cellular metabolic process (GO:0044237)	0.69	4	ARID1A, SMARCB1, SMARCA4, ARID1B
macromolecule metabolic process (GO:0043170)	0.83	4	ARID1A, SMARCB1, SMARCA4, ARID1B
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	4	ARID1A, SMARCB1, SMARCA4, ARID1B
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	4	ARID1A, SMARCB1, SMARCA4, ARID1B
positive regulation of gene expression (GO:0010628)	2.35	4	ARID1A, SMARCB1, SMARCA4, ARID1B
transcription, DNA-templated (GO:0006351)	1.91	4	ARID1A, SMARCB1, SMARCA4, ARID1B
aromatic compound biosynthetic process (GO:0019438)	1.7	4	ARID1A, SMARCB1, SMARCA4, ARID1B
cellular component disassembly (GO:0022411)	3.52	4	SMARCE1, SMARCB1, ARID1A, SMARCA4
negative regulation of cellular process (GO:0048523)	1.41	4	SMARCE1, ARID1A, SMARCB1, SMARCA4
positive regulation of cellular process (GO:0048522)	1.3	4	ARID1A, ARID1B, SMARCB1, SMARCA4
single-organism developmental process (GO:0044767)	1.49	3	SMARCB1, ARID1A, SMARCA4
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	3	SMARCE1, ARID1A, SMARCA4
negative regulation of biosynthetic process (GO:0009890)	2.47	3	SMARCE1, ARID1A, SMARCA4
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	3	SMARCE1, ARID1A, SMARCA4
negative regulation of RNA metabolic process (GO:0051253)	2.66	3	SMARCE1, ARID1A, SMARCA4
cell differentiation (GO:0030154)	2.14	3	SMARCE1, ARID1A, SMARCB1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	3	SMARCE1, ARID1A, SMARCA4
negative regulation of nucleic acid-templated transcription (GO:1903507)	2.71	3	SMARCE1, ARID1A, SMARCA4
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	3	SMARCE1, ARID1A, SMARCA4
negative regulation of gene expression (GO:0010629)	2.48	3	SMARCE1, ARID1A, SMARCA4
negative regulation of transcription, DNA-templated (GO:0045892)	2.75	3	SMARCE1, ARID1A, SMARCA4
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	3	SMARCE1, ARID1A, SMARCA4
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	3	SMARCE1, ARID1A, SMARCA4
positive regulation of response to stimulus (GO:0048584)	2.18	2	SMARCB1, SMARCA4
regulation of response to stimulus (GO:0048583)	1.54	2	SMARCB1, SMARCA4
positive regulation of homeostatic process (GO:0032846)	4.38	2	SMARCB1, SMARCA4
regulation of homeostatic process (GO:0032844)	3.65	2	SMARCB1, SMARCA4
positive regulation of signaling (GO:0023056)	2.41	2	SMARCB1, SMARCA4
modulation by host of symbiont transcription (GO:0052472)	6.68	2	SMARCB1, SMARCA4
regulation of signaling (GO:0023051)	1.72	2	SMARCB1, SMARCA4
positive regulation of cell communication (GO:0010647)	2.41	2	SMARCB1, SMARCA4
regulation of cell communication (GO:0010646)	1.73	2	SMARCB1, SMARCA4
positive regulation of viral transcription (GO:0050434)	6.07	2	SMARCB1, SMARCA4
reproductive process (GO:0022414)	2.55	2	ARID1A, SMARCA4
positive regulation of glucose mediated signaling pathway (GO:1902661)	8.63	2	SMARCB1, SMARCA4
regulation of viral life cycle (GO:1903900)	4.6	2	SMARCB1, SMARCA4
positive regulation of viral life cycle (GO:1903902)	5.26	2	SMARCB1, SMARCA4
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	3.12	2	ARID1A, SMARCA4
regulation of signal transduction (GO:0009966)	1.84	2	SMARCB1, SMARCA4
positive regulation of signal transduction (GO:0009967)	2.5	2	SMARCB1, SMARCA4
regulation of gene expression, epigenetic (GO:0040029)	4.58	2	ARID1A, ARID1B
modification by host of symbiont morphology or physiology (GO:0051851)	5.8	2	SMARCB1, SMARCA4
interspecies interaction between organisms (GO:0044419)	3.08	2	SMARCB1, SMARCA4
positive regulation of transcription from RNA polymerase I promoter (GO:0045943)	7.09	2	SMARCB1, SMARCA4
modification of morphology or physiology of other organism involved in symbiotic interaction (GO:0051817)	5.27	2	SMARCB1, SMARCA4
regulation of viral transcription (GO:0046782)	5.62	2	SMARCB1, SMARCA4
positive regulation of molecular function (GO:0044093)	2.23	2	SMARCB1, SMARCA4
regulation of molecular function (GO:0065009)	1.78	2	SMARCB1, SMARCA4
regulation of biological quality (GO:0065008)	1.68	2	SMARCB1, SMARCA4
positive regulation of gene expression, epigenetic (GO:0045815)	5.76	2	ARID1A, ARID1B
chromatin-mediated maintenance of transcription (GO:0048096)	7.65	2	ARID1A, ARID1B
regulation of viral process (GO:0050792)	3.89	2	SMARCB1, SMARCA4
positive regulation of multi-organism process (GO:0043902)	4.68	2	SMARCB1, SMARCA4
developmental process involved in reproduction (GO:0003006)	3.36	2	ARID1A, SMARCA4
regulation of multi-organism process (GO:0043900)	3.6	2	SMARCB1, SMARCA4
modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)	6.64	2	SMARCB1, SMARCA4
modulation by host of viral transcription (GO:0043921)	6.68	2	SMARCB1, SMARCA4
positive regulation by host of viral transcription (GO:0043923)	7.24	2	SMARCB1, SMARCA4
interaction with symbiont (GO:0051702)	5.76	2	SMARCB1, SMARCA4
regulation of glucose mediated signaling pathway (GO:1902659)	8.34	2	SMARCB1, SMARCA4
regulation of cellular component organization (GO:0051128)	2.01	2	SMARCB1, SMARCA4
multi-organism process (GO:0051704)	2.65	2	SMARCB1, SMARCA4
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091)	4.29	2	SMARCB1, SMARCA4
single organism reproductive process (GO:0044702)	2.73	2	ARID1A, SMARCA4
regulation of symbiosis, encompassing mutualism through parasitism (GO:0043903)	3.82	2	SMARCB1, SMARCA4
regulation of transcription from RNA polymerase I promoter (GO:0006356)	6.59	2	SMARCB1, SMARCA4
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090)	3.83	2	SMARCB1, SMARCA4
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	2	SMARCB1, SMARCA4
positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter (GO:1901838)	7.94	2	SMARCB1, SMARCA4
regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter (GO:1901836)	7.53	2	SMARCB1, SMARCA4
positive regulation of viral process (GO:0048524)	5.11	2	SMARCB1, SMARCA4
modification of morphology or physiology of other organism (GO:0035821)	5.12	2	SMARCB1, SMARCA4

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
nucleosome organization (GO:0034728)	-	4.79	0.0	SMARCE1, SMARCB1, ARID1A, SMARCA4
ATP-dependent chromatin remodeling (GO:0043044)	-	5.6	0.0	SMARCE1, SMARCB1, ARID1A, SMARCA4
blastocyst hatching (GO:0001835)	NEW	9.04	0.001	SMARCB1, SMARCA4
positive regulation of gene expression (GO:0010628)	-	2.35	0.038	ARID1A, SMARCB1, SMARCA4, ARID1B
modulation by host of symbiont transcription (GO:0052472)	-	6.68	0.004	SMARCB1, SMARCA4
positive regulation of viral transcription (GO:0050434)	-	6.07	0.029	SMARCB1, SMARCA4
protein complex disassembly (GO:0043241)	-	4.58	0.0	SMARCE1, ARID1A, SMARCB1, SMARCA4
protein-DNA complex disassembly (GO:0032986)	-	6.9	0.0	SMARCE1, SMARCB1, ARID1A, SMARCA4
macromolecular complex disassembly (GO:0032984)	-	4.53	0.0	SMARCE1, SMARCB1, ARID1A, SMARCA4
protein complex subunit organization (GO:0071822)	-	2.6	0.03	SMARCE1, ARID1A, SMARCB1, SMARCA4
chromatin organization (GO:0006325)	-	3.28	0.0	SMARCE1, SMARCB1, ARID1B, ARID1A, SMARCA4
hatching (GO:0035188)	NEW	9.04	0.001	SMARCB1, SMARCA4
single-organism organelle organization (GO:1902589)	NEW	2.68	0.047	SMARCE1, SMARCB1, ARID1A, SMARCA4
modification by host of symbiont morphology or physiology (GO:0051851)	-	5.8	0.008	SMARCB1, SMARCA4
modification of morphology or physiology of other organism involved in symbiotic interaction (GO:0051817)	-	5.27	0.036	SMARCB1, SMARCA4
regulation of gene expression, epigenetic (GO:0040029)	-	4.58	0.001	ARID1A, SMARCB1, SMARCA4, ARID1B
protein-DNA complex subunit organization (GO:0071824)	-	4.45	0.0	SMARCE1, ARID1A, SMARCB1, SMARCA4
chromatin-mediated maintenance of transcription (GO:0048096)	-	7.65	0.003	ARID1A, ARID1B
modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)	-	6.64	0.004	SMARCB1, SMARCA4
cellular component disassembly (GO:0022411)	-	3.52	0.041	SMARCE1, SMARCB1, ARID1A, SMARCA4
modulation by host of viral transcription (GO:0043921)	-	6.68	0.004	SMARCB1, SMARCA4
positive regulation by host of viral transcription (GO:0043923)	-	7.24	0.011	SMARCB1, SMARCA4
interaction with symbiont (GO:0051702)	-	5.76	0.009	SMARCB1, SMARCA4
positive regulation of gene expression, epigenetic (GO:0045815)	-	5.76	0.0	ARID1A, SMARCA4, ARID1B
nervous system development (GO:0007399)	-	3.53	0.011	SMARCE1, SMARCB1, ARID1B
chromatin remodeling (GO:0006338)	-	4.78	0.0	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
nucleosome disassembly (GO:0006337)	-	6.9	0.0	SMARCE1, ARID1A, SMARCB1, SMARCA4
anatomical structure development (GO:0048856)	-	1.58	0.022	SMARCE1, SMARCB1, SMARCA4, ARID1B, ARID1A
organism emergence from protective structure (GO:0071684)	NEW	9.04	0.001	SMARCB1, SMARCA4
positive regulation of RNA metabolic process (GO:0051254)	-	2.51	0.033	SMARCB1, SMARCA4, ARID1B, ARID1A
positive regulation of RNA biosynthetic process (GO:1902680)	-	2.54	0.031	ARID1A, SMARCB1, SMARCA4, ARID1B
positive regulation of macromolecule biosynthetic process (GO:0010557)	-	2.39	0.05	ARID1A, SMARCB1, SMARCA4, ARID1B
forebrain development (GO:0030900)	NEW	5.48	0.027	ARID1A, SMARCA4
chromatin modification (GO:0016568)	-	4.06	0.001	SMARCE1, SMARCB1, SMARCA4, ARID1B, ARID1A
positive regulation of transcription, DNA-templated (GO:0045893)	-	2.56	0.027	ARID1A, SMARCB1, SMARCA4, ARID1B

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
protein complex (GO:0043234)	1.51	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
intracellular organelle part (GO:0044446)	0.81	5	SMARCE1, SMARCB1, ARID1B, ARID1A, SMARCA4
SWI/SNF superfamily-type complex (GO:0070603)	5.5	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
intracellular membrane-bounded organelle (GO:0043231)	0.6	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
nBAF complex (GO:0071565)	7.16	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
nucleus (GO:0005634)	1.07	5	SMARCE1, SMARCB1, ARID1B, ARID1A, SMARCA4
cell part (GO:0044464)	0.11	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
nucleoplasm (GO:0005654)	1.89	5	SMARCE1, SMARCB1, ARID1B, ARID1A, SMARCA4
neuron part (GO:0097458)	2.64	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
intracellular organelle (GO:0043229)	0.51	5	SMARCE1, SMARCB1, ARID1B, ARID1A, SMARCA4
nuclear part (GO:0044428)	1.55	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
SWI/SNF complex (GO:0016514)	7.09	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
intracellular part (GO:0044424)	0.28	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
macromolecular complex (GO:0032991)	1.35	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
BAF-type complex (GO:0090544)	6.67	5	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
membrane-bounded organelle (GO:0043227)	0.47	5	SMARCE1, SMARCB1, SMARCA4, ARID1B, ARID1A
organelle (GO:0043226)	0.4	5	SMARCE1, SMARCB1, SMARCA4, ARID1B, ARID1A
organelle part (GO:0044422)	0.79	5	SMARCE1, SMARCB1, ARID1B, ARID1A, SMARCA4
nuclear chromosome part (GO:0044454)	3.67	4	SMARCE1, SMARCB1, ARID1A, SMARCA4
nuclear chromatin (GO:0000790)	4.42	4	SMARCE1, SMARCB1, ARID1A, SMARCA4
chromosomal part (GO:0044427)	3.18	4	SMARCE1, ARID1A, SMARCB1, SMARCA4
chromatin (GO:0000785)	3.99	4	SMARCE1, SMARCB1, ARID1A, SMARCA4
npBAF complex (GO:0071564)	7.32	4	SMARCE1, SMARCB1, ARID1A, SMARCA4
non-membrane-bounded organelle (GO:0043228)	1.76	3	SMARCE1, SMARCB1, SMARCA4
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	3	SMARCE1, SMARCB1, SMARCA4
nuclear chromosome (GO:0000228)	5.55	2	SMARCE1, SMARCB1
chromosome (GO:0005694)	3.78	2	SMARCE1, SMARCB1
nucleolus (GO:0005730)	3.06	2	SMARCB1, SMARCA4

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
protein complex (GO:0043234)	-	1.51	0.017	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
macromolecular complex (GO:0032991)	-	1.35	0.04	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
neuron part (GO:0097458)	-	2.64	0.001	SMARCE1, ARID1A, SMARCB1, SMARCA4
nBAF complex (GO:0071565)	-	7.16	0.0	SMARCE1, SMARCB1, ARID1A, SMARCA4
nuclear chromosome part (GO:0044454)	-	3.67	0.0	SMARCE1, SMARCB1, ARID1A, SMARCA4
nuclear chromatin (GO:0000790)	-	4.42	0.0	SMARCE1, SMARCB1, ARID1A, SMARCA4
chromatin (GO:0000785)	-	3.99	0.001	SMARCE1, SMARCB1, ARID1A, SMARCA4
npBAF complex (GO:0071564)	-	7.32	0.0	SMARCE1, SMARCB1, ARID1A, SMARCA4
SWI/SNF complex (GO:0016514)	-	7.09	0.0	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
nuclear part (GO:0044428)	-	1.55	0.002	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
nuclear chromosome (GO:0000228)	-	5.55	0.033	SMARCE1, SMARCA4
chromosomal part (GO:0044427)	-	3.18	0.0	SMARCE1, ARID1A, SMARCB1, SMARCA4
chromosome (GO:0005694)	-	3.78	0.01	SMARCE1, SMARCB1, SMARCA4
BAF-type complex (GO:0090544)	-	6.67	0.0	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B
SWI/SNF superfamily-type complex (GO:0070603)	-	5.5	0.0	SMARCE1, ARID1A, SMARCB1, SMARCA4, ARID1B