Disease table of OBESITY OMIM ID: 601665

Gene-disease associations table

GeneAssociated with OBESITY inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
SIM1OMIMHGNC link6q16.31601665
GHRLOMIMHGNC link3p25.31601665
NR0B2OMIMHGNC link1p36.111601665
SDC3OMIMHGNC link1p35.21601665
AGRPOMIMHGNC link16q22.11601665
ENPP1OMIMHGNC link6q23.25615522, PS193100, 125853, 601665, PS208000
PPARGOMIM, HUMSAVARHGNC link3p25.25601665, PS137800, 125853, 609338, PS151660
ADRB2OMIMHGNC link5q322600807, 601665
ADRB3OMIMHGNC link8p11.231601665
PPARGC1BOMIMHGNC link5q321601665
POMCOMIMHGNC link2p23.32609734, 601665
CARTPTOMIMHGNC link5q13.21601665
UCP1OMIMHGNC link4q31.11601665
UCP3OMIM, HUMSAVARHGNC link11q13.41601665
MC4ROMIM, HUMSAVARHGNC link18q21.322181500, 601665

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
5q322ADRB2, PPARGC1B
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
5q322ADRB2, PPARGC1B
3p252PPARG, GHRL
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
3p22PPARG, GHRL
1p32NR0B2, SDC3
5q32ADRB2, PPARGC1B
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
1p2NR0B2, SDC3
3p2PPARG, GHRL
5q3ADRB2, CARTPT, PPARGC1B
6q2SIM1, ENPP1
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
12NR0B2, SDC3
32PPARG, GHRL
53ADRB2, CARTPT, PPARGC1B
62SIM1, ENPP1
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
NR0B2YES9PTGS2, CYP7A1, CYP27A1, CYP8B1, SMAD3, PCK2, SERPINE1, E2F1, G6PC0
PPARGYES69BCL2L1, EGFR, PLIN2, TNFRSF11B, CPT1B, DEFB103A, NOTCH4, VLDLR, SAT1, TP53, DBI, CAV1, CIDEA, PDK2, SERPINE1, CFLAR, ATP2A2, STAT6, ICAM1, TXNIP, FABP4, PTGS2, JAG1, CCNE1, GDF15, CEBPA, KLF5, GK, APOBR, ERO1L, RETN, CD83, TG, AGER, CAT, CSF1, POU2F1, BCL2, REN, UGT1A9, CDKN1A, CLDN2, ERP44, RARB, ANGPTL4, ADIPOQ, SOCS7, PTEN, BAD, SLC2A4, FGF1, SLC9A1, CD36, ABCG2, MMP1, BRS3, NR1H3, TSHR, LIPE, SLC5A5, ACAT1, MMP9, APOB, HMOX1, CIITA, MYC, CCND1, KLF4, FASLG0
SREBF1NO27AR, FABP6, LPIN1, BCL2L1, CAV1, ACACB, SCD, THRSP, CIC, PDX1, SCD5, FAS, PCSK9, LDLR, FDPS, LRP1, IRS2, PCK1, FDFT1, HK2, NR0B2, ACLY, FASN, APOA5, CETP, HMOX1, PPARG2PPARG, NR0B2
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
NR0B2YES4CLOCK, EP300, SREBF1, ATF60
PPARGYES14NCOR1, UHRF1, SREBF1, EGR1, SREBF2, CDX1, RB1, CEBPD, SIRT1, NR4A3, KLF2, E2F1, GATA2, STAT10
ADRB2YES1EZH20
ADRB3YES1SP10
CARTPTYES1REST0
UCP1YES1PPARA0
PTGS2NO41AR, ING4, TFAP2A, TCF7L2, CREB1, PGR, JUND, FOS, NFATC4, SP1, ETV4, STAT2, EGR1, STAT6, USF2, DR1, CTNNB1, HMGA1, PPARA, APC, EP300, HDAC1, STAT3, ATF2, JUN, RELA, HDAC4, SETBP1, NFKB1, STAT1, ELF3, NR0B2, CREBBP, NFIL3, CDX1, CEBPB, CEBPD, CDX2, JUNB, PPARG, USF12PPARG, NR0B2
SERPINE1NO23SRF, PARP1, SP1, HSF1, KLF5, SMAD3, E2F1, PPARA, TGIF1, ESR2, NR4A1, SMAD4, RELA, EPAS1, ARNTL2, NFKB1, NR0B2, YY1, KLF10, HIF1A, ESR1, PPARG, USF12PPARG, NR0B2
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
NR0B2PPARGYes8MDM2, VDR, HDAC1, NCOA3, HDAC3, RXRA, PPARG, RXRG
NR0B2ADRB2No2HDAC6, MDM2
NR0B2PPARGC1BNo4NR1H2, PPARG, ESR1, HNF4A
SDC3ADRB2No3TUBB2A, ARRB2, TUBB
AGRPPOMCNo1MC4R
AGRPMC4RYes0
ENPP1ADRB2No1PON2
PPARGADRB2No6MDM2, KCTD13, PHB2, SERPINH1, UBC, NEDD4
PPARGPPARGC1BYes3PIAS1, PPARG, ZBTB9
PPARGPOMCNo1APP
PPARGUCP3No1YWHAB
ADRB2ADRB3No2SRC, ARRDC3
ADRB2PPARGC1BNo1SRC
ADRB2CARTPTNo1CEACAM1
ADRB3PPARGC1BNo1SRC
POMCMC4RYes0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
SIM1GHRLNo-2LEP, OXT
SIM1AGRPNo-1LEP
SIM1PPARGNo-1LEP
SIM1POMCNo-1LEP
SIM1CARTPTNo-1LEP
SIM1UCP1No-1LEP
SIM1UCP3No-1LEP
SIM1MC4RNo-1LEP
GHRLSDC3No-2POMC, IL8
GHRLAGRPNo-3LEP, FOS, POMC
GHRLPPARGNo-5INS, LEP, FOS, UCP2, UCP1
GHRLADRB2No-3GHRH, POMC, GCG
GHRLADRB3No-3GHRH, POMC, GCG
GHRLPOMCYesactivation9GHRH, HSPA4, PPY, INS, IL8, LEP, FOS, NPY, GCG
GHRLCARTPTNo-1LEP
GHRLUCP1Yesexpression4INS, LEP, UCP2, NPY
GHRLUCP3No-4INS, LEP, UCP2, UCP1
GHRLMC4RNo-4LEP, POMC, GHRH, GCG
NR0B2SDC3No-1SRC
NR0B2AGRPNo-1SIRT1
NR0B2PPARGYesbinding42RARB, RORC, NR2C2, NR5A1, ESRRG, NR2F1, PGR, NR1H2, RXRG, RORA, NR2C2AP, ESR2, PPARD, NR2C1, RORB, THRB, HDAC3, RARG, HNF4G, NRBP1, PPARA, NR4A2, SIRT1, PPARGC1A, THRA, VDR, AR, HDAC1, RARA, NFE2L2, NR4A1, TP53, NR2E1, ESRRB, NR1D1, NR2F6, MED1, ESRRA, ESR1, UBC, NR1D2, HNF4A
NR0B2ADRB2No-2SRC, UBC
NR0B2ADRB3No-3SRC, PPARA, PPARG
NR0B2PPARGC1BNo-5MED1, PPARA, ESRRG, ESR1, ESRRA
NR0B2POMCNo-2NR1H3, NR4A1
NR0B2UCP1No-3PPARA, PPARGC1A, PPARG
NR0B2UCP3No-4NR4A1, PPARG, SIRT1, PPARA
SDC3AGRPYesbinding, expression2MC4R, POMC
SDC3ENPP1No-2FGF2, FGF13
SDC3PPARGNo-1APOE
SDC3ADRB2No-3SRC, MC4R, POMC
SDC3ADRB3No-3SRC, MC4R, POMC
SDC3POMCYesactivation, binding6AGRP, APOE, FGF13, MC4R, IL8, FGF2
SDC3MC4RYesbinding2AGRP, POMC
AGRPPPARGNo-4LEP, FOS, FOXO1, SIRT1
AGRPADRB2No-4MC4R, POMC, MC3R, BDNF
AGRPADRB3No-3MC4R, POMC, MC3R
AGRPPOMCYesbinding, activation, expression6SDC3, MC3R, MC4R, FOXO1, LEP, FOS
AGRPCARTPTNo-1LEP
AGRPUCP1No-1LEP
AGRPUCP3No-4ATIC, LEP, SIRT1, C10ORF10
AGRPMC4RYesbinding, expression6SDC3, TRH, BDNF, POMC, MC3R, LEP
ENPP1POMCNo-2FGF2, FGF13
PPARGADRB2No-2UBC, ADRB3
PPARGADRB3Yesbinding1PPARA
PPARGPPARGC1BNo-27NCOA6, MED24, MED26, ESRRG, HELZ2, CDK8, MED8, MED20, MED13, MED6, NCOA2, PPARA, MED18, ESRRA, MED17, MED30, MED1, NCOA1, MED12, MED14, MED4, MED29, MED16, MED21, ESR1, MED11, CREBBP
PPARGPOMCNo-14SP1, IL2, FOXO1, APOE, CCR2, ADRB3, INS, SCARB1, NR4A1, HMOX1, IL4, LEP, FOS, VEGFA
PPARGCARTPTNo-1LEP
PPARGUCP1Yesactivation, binding7PPARGC1A, NRIP1, UCP2, INS, UCP3, LEP, PPARA
PPARGUCP3Yesactivation, binding10SLC2A4, UCP2, PRKAA2, INS, PRKAA1, NR4A1, UCP1, LEP, PPARA, SIRT1
PPARGMC4RNo-2LEP, ADRB3
ADRB2ADRB3Yesbinding71DRD5, MC3R, GNG2, GRK1, MC4R, RXFP2, CRHR2, TAAR1, ADORA2A, TSHR, MC1R, ADCYAP1R1, HTR4, ADM2, ADRBK2, NPSR1, CRH, GCG, ADM, PTH, IAPP, HTR7, CALCB, GRK4, PTH1R, GLP1R, CALCR, ARRB2, PTHLH, POMC, GRK6, ADCYAP1, ARRB1, ADRBK1, SCT, PTGDR, GCGR, GIP, VIPR2, ADORA2B, AVP, FSHR, NPS, GHRHR, GNAL, GRK5, GHRH, HRH2, GRK7, GNAS, SRC, RXFP1, GLP2R, SCTR, ADRB1, GPBAR1, MC2R, MC5R, PTGER4, DRD1, PTGIR, VIPR1, PTGER2, HTR6, GNAI3, VIP, GNB1, LHCGR, PTH2R, GIPR, PTH2
ADRB2POMCYesreaction, activation, binding64DRD5, MC3R, GNG2, MC1R, RXFP2, CRHR2, TAAR1, ADORA2A, TSHR, CXCL12, AGT, HTR4, ADM2, NPSR1, CRH, GCG, ADM, PTH, PTH2R, HTR7, CALCB, FSHR, PTH1R, IAPP, CALCR, GIPR, PTHLH, SCTR, ADCYAP1, GLP1R, NPS, SCT, PTGIR, GCGR, GIP, MC5R, ADORA2B, AVP, GHRHR, VIPR2, ADRB3, PTGDR, HRH2, CCR3, GNAS, CCR5, RXFP1, GLP2R, GHRH, ADRB1, GPBAR1, MC2R, PTGER4, DRD1, VIPR1, PTGER2, HTR6, GNAI3, VIP, GNB1, LHCGR, ADCYAP1R1, MC4R, PTH2
ADRB2MC4RYesreaction, binding60DRD5, MC3R, GNG2, MC1R, RXFP2, CRHR2, TAAR1, ADORA2A, PTGER2, ADCYAP1R1, HTR4, ADM2, NPSR1, CRH, GCG, ADM, IAPP, HTR7, CALCB, FSHR, PTH1R, CALCR, RXFP1, PTHLH, POMC, SCTR, ADCYAP1, PTGIR, NPS, SCT, GLP1R, GCGR, GIP, MC5R, ADORA2B, AVP, GHRHR, VIPR2, ADRB3, PTGDR, BDNF, HRH2, PTGER4, GNAS, GLP2R, GHRH, ADRB1, GPBAR1, MC2R, DRD1, VIPR1, TSHR, HTR6, PTH, VIP, GNB1, LHCGR, PTH2R, GIPR, PTH2
ADRB3PPARGC1BNo-1PPARA
ADRB3POMCYesreaction, activation60DRD5, MC3R, GNG2, MC1R, RXFP2, CRHR2, TAAR1, ADORA2A, PTGER2, ADCYAP1R1, HTR4, ADM2, NPSR1, CRH, GCG, ADM, PTH, IAPP, HTR7, CALCB, FSHR, PTH1R, CALCR, GIPR, PTHLH, SCTR, ADCYAP1, GLP1R, NPS, SCT, PTGDR, GCGR, GIP, MC5R, ADORA2B, AVP, ADRB2, GHRHR, VIPR2, GHRH, HRH2, GNAS, RXFP1, GLP2R, ADRB1, GPBAR1, MC2R, PTGER4, DRD1, PTGIR, VIPR1, TSHR, HTR6, GNAI3, VIP, GNB1, LHCGR, PTH2R, MC4R, PTH2
ADRB3UCP1No-2PPARA, PPARG
ADRB3UCP3No-2PPARA, PPARG
ADRB3MC4RYesreaction59DRD5, MC3R, GNG2, MC1R, RXFP2, CRHR2, TAAR1, ADORA2A, PTGER2, ADCYAP1R1, HTR4, ADM2, NPSR1, CRH, GCG, ADM, IAPP, HTR7, CALCB, FSHR, PTH1R, CALCR, GIPR, PTHLH, POMC, SCTR, ADCYAP1, PTGIR, NPS, SCT, GLP1R, GCGR, GIP, MC5R, ADORA2B, AVP, ADRB2, GHRHR, VIPR2, PTGDR, HRH2, PTGER4, GNAS, GLP2R, GHRH, ADRB1, GPBAR1, MC2R, DRD1, VIPR1, TSHR, HTR6, PTH, VIP, GNB1, LHCGR, PTH2R, RXFP1, PTH2
PPARGC1BUCP1No-1PPARA
PPARGC1BUCP3No-1PPARA
POMCCARTPTNo-1LEP
POMCUCP1No-5INS, IL6, LEP, NPY, GHRL
POMCUCP3No-3INS, LEP, NR4A1
POMCMC4RYesactivation, binding62GLP1R, DRD5, MC3R, GNG2, MC1R, RXFP2, CRHR2, TAAR1, ADORA2A, PTGER2, ADCYAP1R1, HTR4, ADM2, NPSR1, PTGER4, GCG, ADM, SDC3, HTR7, CALCB, FSHR, PTH1R, IAPP, CALCR, GIPR, PTHLH, SCTR, ADCYAP1, PTGIR, NPS, SCT, PTGDR, GCGR, GIP, MC5R, ADORA2B, AVP, ADRB2, GHRHR, VIPR2, ADRB3, CRH, HRH2, GNAS, LEP, AGRP, GLP2R, GHRH, ADRB1, GPBAR1, MC2R, DRD1, VIPR1, TSHR, HTR6, PTH, VIP, GNB1, LHCGR, PTH2R, RXFP1, PTH2
CARTPTUCP1No-1LEP
CARTPTUCP3No-1LEP
CARTPTMC4RNo-1LEP
UCP1UCP3Yesbinding5INS, PPARA, LEP, PPARG, UCP2
UCP1MC4RNo-1LEP
UCP3MC4RNo-1LEP

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Neuroactive ligand-receptor interactionhsa040804.583ADRB2, ADRB3, MC4R
Salivary secretionhsa049706.232ADRB2, ADRB3
cGMP-PKG signaling pathwayhsa040225.322ADRB2, ADRB3
Calcium signaling pathwayhsa040205.222ADRB2, ADRB3
PPAR signaling pathwayhsa033206.562PPARG, UCP1
cAMP signaling pathwayhsa040245.052ADRB2, GHRL
Endocytosishsa041444.922ADRB2, ADRB3
Huntington's diseasehsa050165.172PPARG, UCP1
Adipocytokine signaling pathwayhsa049206.62AGRP, POMC

NET-GE enrichment

Term New enriched termICP valueGenes
Bile secretion (hsa04976) NEW6.560.005PPARG, ADRB2, NR0B2, POMC
Neuroactive ligand-receptor interaction (hsa04080) -4.580.047ADRB3, ADRB2, POMC, PPARG, MC4R
Endocrine systemNEW3.260.009ADRB2, NR0B2, MC4R, ADRB3, AGRP, GHRL, POMC, PPARG, UCP1
cAMP signaling pathway (hsa04024) -5.050.035ADRB3, POMC, PPARG, ADRB2, GHRL
Adipocytokine signaling pathway (hsa04920) -6.60.0GHRL, POMC, PPARG, AGRP, UCP1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
MetabolismR-HSA-14307282.347SDC3, ENPP1, UCP3, POMC, PPARGC1B, PPARG, UCP1
Signal TransductionR-HSA-1625821.786ADRB2, MC4R, SDC3, ADRB3, POMC, GHRL
GPCR downstream signalingR-HSA-3883963.075ADRB2, MC4R, ADRB3, GHRL, POMC
Class A/1 (Rhodopsin-like receptors)R-HSA-3730764.695GHRL, MC4R, ADRB3, ADRB2, POMC
GPCR ligand bindingR-HSA-5007924.195ADRB2, MC4R, ADRB3, GHRL, POMC
Signaling by GPCRR-HSA-3727902.685POMC, MC4R, ADRB3, ADRB2, GHRL
G alpha (s) signalling eventsR-HSA-4185555.994ADRB2, POMC, ADRB3, MC4R
Metabolism of lipids and lipoproteinsR-HSA-5568333.793PPARGC1B, PPARG, POMC
Peptide ligand-binding receptorsR-HSA-3752765.413POMC, MC4R, GHRL
Nuclear Receptor transcription pathwayR-HSA-3832807.312NR0B2, PPARG
PPARA activates gene expressionR-HSA-19897816.182PPARGC1B, PPARG
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.R-HSA-1632006.122UCP3, UCP1
Amine ligand-binding receptorsR-HSA-3752807.592ADRB2, ADRB3
Gene ExpressionR-HSA-741602.722NR0B2, PPARG
Generic Transcription PathwayR-HSA-2124363.862NR0B2, PPARG
The citric acid (TCA) cycle and respiratory electron transportR-HSA-14285175.712UCP3, UCP1
The fatty acid cycling modelR-HSA-16782610.662UCP3, UCP1
The proton buffering modelR-HSA-16782710.662UCP3, UCP1
Peptide hormone metabolismR-HSA-29807366.612POMC, GHRL
Mitochondrial Uncoupling ProteinsR-HSA-16618710.662UCP3, UCP1
Metabolism of proteinsR-HSA-3924993.412GHRL, POMC
Fatty acid, triacylglycerol, and ketone body metabolismR-HSA-5357345.442PPARGC1B, PPARG
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)R-HSA-4002066.142PPARGC1B, PPARG
AdrenoceptorsR-HSA-3906969.812ADRB2, ADRB3
DiseaseR-HSA-16436853.332SDC3, POMC

NET-GE enrichment

Term New enriched termICP valueGenes
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076) -4.690.004ADRB2, MC4R, ADRB3, POMC, GHRL, PPARG
The proton buffering model (R-HSA-167827) -10.660.006UCP3, UCP1
Adrenoceptors (R-HSA-390696) -9.810.021ADRB2, ADRB3
Mitochondrial Uncoupling Proteins (R-HSA-166187) -10.660.006UCP3, UCP1
Metabolism (R-HSA-1430728) -2.340.0SDC3, NR0B2, ADRB3, MC4R, ENPP1, AGRP, SIM1, ADRB2, GHRL, UCP3, PPARGC1B, POMC, PPARG, UCP1
GPCR ligand binding (R-HSA-500792) -4.190.019ADRB2, MC4R, ADRB3, POMC, GHRL
G alpha (s) signalling events (R-HSA-418555) -5.990.002ADRB3, ADRB2, POMC, PPARG, MC4R
The fatty acid cycling model (R-HSA-167826) -10.660.006UCP3, UCP1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.1814SDC3, NR0B2, CARTPT, ADRB3, MC4R, ENPP1, AGRP, SIM1, ADRB2, GHRL, UCP3, PPARGC1B, POMC, PPARG
protein binding (GO:0005515) 0.4614SDC3, NR0B2, CARTPT, ADRB3, MC4R, ENPP1, AGRP, SIM1, ADRB2, GHRL, UCP3, PPARGC1B, POMC, PPARG
receptor binding (GO:0005102) 2.439ADRB2, NR0B2, ADRB3, ENPP1, AGRP, GHRL, PPARGC1B, POMC, PPARG
organic cyclic compound binding (GO:0097159) 1.057ADRB2, NR0B2, ADRB3, ENPP1, SIM1, PPARGC1B, PPARG
molecular transducer activity (GO:0060089) 2.326ADRB2, NR0B2, ENPP1, MC4R, ADRB3, PPARG
receptor activity (GO:0004872) 2.326ADRB2, NR0B2, ENPP1, MC4R, ADRB3, PPARG
signaling receptor activity (GO:0038023) 2.495PPARG, ADRB3, ADRB2, NR0B2, MC4R
nucleic acid binding (GO:0003676) 1.445ENPP1, PPARGC1B, NR0B2, PPARG, SIM1
signal transducer activity (GO:0004871) 2.285ADRB3, ADRB2, PPARG, MC4R, NR0B2
protein dimerization activity (GO:0046983) 2.725ADRB3, ADRB2, NR0B2, SIM1, ENPP1
heterocyclic compound binding (GO:1901363) 1.065PPARG, PPARGC1B, NR0B2, SIM1, ENPP1
identical protein binding (GO:0042802) 2.635ADRB3, ENPP1, ADRB2, NR0B2, PPARG
G-protein coupled receptor activity (GO:0004930) 2.954ADRB3, ADRB2, PPARG, MC4R
transmembrane signaling receptor activity (GO:0004888) 2.574ADRB3, ADRB2, PPARG, MC4R
macromolecular complex binding (GO:0044877) 2.614PPARG, ADRB2, NR0B2, ENPP1
G-protein coupled receptor binding (GO:0001664) 4.184ADRB2, ADRB3, POMC, GHRL
transmembrane receptor activity (GO:0099600) 2.534ADRB3, ADRB2, PPARG, MC4R
protein homodimerization activity (GO:0042803) 3.164ADRB3, ADRB2, NR0B2, ENPP1
hormone activity (GO:0005179) 4.953GHRL, POMC, AGRP
transcription factor binding (GO:0008134) 3.463PPARG, PPARGC1B, NR0B2
DNA binding (GO:0003677) 1.923PPARG, NR0B2, SIM1
nuclear hormone receptor binding (GO:0035257) 4.73PPARG, PPARGC1B, NR0B2
transcription cofactor activity (GO:0003712) 3.443PPARG, PPARGC1B, NR0B2
enzyme binding (GO:0019899) 2.273ADRB2, PPARG, MC4R
transcription factor activity, transcription factor binding (GO:0000989) 3.363NR0B2, PPARGC1B, PPARG
transcription factor activity, protein binding (GO:0000988) 3.353PPARG, PPARGC1B, NR0B2
protein complex binding (GO:0032403) 3.093ENPP1, ADRB2, NR0B2
hormone receptor binding (GO:0051427) 4.573PPARG, PPARGC1B, NR0B2
molecular function regulator (GO:0098772) 2.513ADRB2, PPARGC1B, GHRL
(GO:0051380) 8.352ADRB2, ADRB3
drug binding (GO:0008144) 5.032ADRB2, PPARG
zinc ion binding (GO:0008270) 2.662ENPP1, PPARG
ion binding (GO:0043167) 1.362ENPP1, PPARG
nucleoside phosphate binding (GO:1901265) 1.962PPARGC1B, ENPP1
cation binding (GO:0043169) 1.42ENPP1, PPARG
transition metal ion binding (GO:0046914) 2.482ENPP1, PPARG
adrenergic receptor activity (GO:0004935) 6.972ADRB2, ADRB3
(GO:0004939) 8.642ADRB2, ADRB3
transcription coactivator activity (GO:0003713) 4.042PPARGC1B, PPARG
nucleotide binding (GO:0000166) 1.962PPARGC1B, ENPP1
structural constituent of ribosome (GO:0003735) 4.322UCP3, UCP1
oxidative phosphorylation uncoupler activity (GO:0017077) 9.052UCP3, UCP1
metal ion binding (GO:0046872) 1.412ENPP1, PPARG
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.292PPARG, SIM1
steroid hormone receptor binding (GO:0035258) 5.322PPARGC1B, PPARG
structural molecule activity (GO:0005198) 3.12UCP3, UCP1
estrogen receptor binding (GO:0030331) 6.052PPARGC1B, PPARG
transporter activity (GO:0005215) 2.572UCP3, UCP1
ligand-dependent nuclear receptor transcription coactivator activity (GO:0030374) 5.772PPARGC1B, PPARG
small molecule binding (GO:0036094) 1.892PPARGC1B, ENPP1
retinoid X receptor binding (GO:0046965) 6.792NR0B2, PPARG
protein domain specific binding (GO:0019904) 3.322PPARGC1B, NR0B2
G-protein coupled amine receptor activity (GO:0008227) 5.832ADRB2, ADRB3
(GO:0051379) 7.952ADRB2, ADRB3
neuropeptide hormone activity (GO:0005184) 6.342AGRP, POMC
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.652PPARG, SIM1
catecholamine binding (GO:1901338) 6.972ADRB2, ADRB3
steroid hormone receptor activity (GO:0003707) 5.662PPARG, NR0B2
transmembrane transporter activity (GO:0022857) 2.822UCP3, UCP1
retinoic acid receptor binding (GO:0042974) 5.832NR0B2, PPARG
nucleic acid binding transcription factor activity (GO:0001071) 2.652PPARG, SIM1

NET-GE enrichment

Term New enriched termICP valueGenes
norepinephrine binding (GO:0051380) -8.350.001ADRB2, POMC
beta-3 adrenergic receptor binding (GO:0031699) NEW9.050.001ADRB2, ADRB3
direct ligand regulated sequence-specific DNA binding transcription factor activity (GO:0098531) NEW5.870.011NR0B2, POMC, PPARG
receptor activity (GO:0004872) -2.320.012SDC3, NR0B2, ADRB3, MC4R, ENPP1, ADRB2, SIM1, GHRL, POMC, PPARG
G-protein coupled receptor binding (GO:0001664) -4.180.002ADRB2, MC4R, ADRB3, POMC, GHRL, PPARG
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0004879) NEW5.870.011NR0B2, POMC, PPARG
adrenergic receptor activity (GO:0004935) -6.970.011ADRB2, ADRB3
beta-adrenergic receptor activity (GO:0004939) -8.640.001ADRB2, ADRB3
oxidative phosphorylation uncoupler activity (GO:0017077) -9.050.0UCP3, PPARG, UCP1
protein homodimerization activity (GO:0042803) -3.160.032ADRB2, NR0B2, ADRB3, ENPP1, SDC3, POMC, PPARG, UCP1
hormone activity (GO:0005179) -4.950.0POMC, MC4R, SDC3, GHRL, AGRP
nuclear hormone receptor binding (GO:0035257) -4.70.029PPARG, PPARGC1B, NR0B2
retinoid X receptor binding (GO:0046965) -6.790.012NR0B2, PPARG
neuropeptide receptor binding (GO:0071855) NEW6.370.002MC4R, ADRB3, POMC
hormone receptor binding (GO:0051427) -4.570.043ADRB2, NR0B2, ADRB3, POMC, PPARGC1B, PPARG
G-protein coupled amine receptor activity (GO:0008227) -5.830.004ADRB2, ADRB3, POMC
epinephrine binding (GO:0051379) -7.950.003POMC, ADRB3
catecholamine binding (GO:1901338) -6.970.033ADRB2, ADRB3
steroid hormone receptor activity (GO:0003707) -5.660.018PPARG, POMC, NR0B2
protein binding (GO:0005515) -0.460.039SDC3, NR0B2, CARTPT, ADRB3, MC4R, ENPP1, AGRP, SIM1, ADRB2, GHRL, UCP3, PPARGC1B, POMC, PPARG
receptor binding (GO:0005102) -2.430.0SDC3, NR0B2, ADRB3, MC4R, ENPP1, ADRB2, SIM1, GHRL, PPARGC1B, POMC, PPARG, UCP1, AGRP
prostaglandin receptor activity (GO:0004955) NEW7.540.041ADRB3, PPARG
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
single-organism process (GO:0044699) 0.4815SDC3, NR0B2, CARTPT, ADRB3, MC4R, ENPP1, ADRB2, SIM1, GHRL, UCP3, PPARGC1B, POMC, PPARG, UCP1, AGRP
cellular process (GO:0009987) 0.2614SDC3, NR0B2, CARTPT, ADRB3, MC4R, ENPP1, ADRB2, SIM1, GHRL, UCP3, PPARGC1B, POMC, PPARG, UCP1
biological regulation (GO:0065007) 0.3913AGRP, NR0B2, CARTPT, ADRB3, MC4R, ENPP1, ADRB2, SIM1, GHRL, PPARGC1B, POMC, PPARG, UCP1
regulation of biological process (GO:0050789) 0.4513AGRP, NR0B2, CARTPT, ADRB3, MC4R, ENPP1, ADRB2, SIM1, GHRL, PPARGC1B, POMC, PPARG, UCP1
metabolic process (GO:0008152) 0.5813SDC3, NR0B2, ADRB3, MC4R, ENPP1, ADRB2, SIM1, GHRL, UCP3, PPARGC1B, POMC, PPARG, UCP1
regulation of cellular process (GO:0050794) 0.513AGRP, NR0B2, CARTPT, ADRB3, MC4R, ENPP1, ADRB2, SIM1, GHRL, PPARGC1B, POMC, PPARG, UCP1
regulation of cellular metabolic process (GO:0031323) 1.0712ADRB2, NR0B2, CARTPT, ADRB3, MC4R, ENPP1, POMC, SIM1, GHRL, PPARGC1B, PPARG, UCP1
single-organism cellular process (GO:0044763) 0.6512ADRB2, CARTPT, ADRB3, MC4R, ENPP1, SDC3, SIM1, GHRL, UCP3, POMC, PPARG, UCP1
regulation of primary metabolic process (GO:0080090) 1.0812ADRB2, NR0B2, CARTPT, ADRB3, MC4R, ENPP1, POMC, SIM1, GHRL, PPARGC1B, PPARG, UCP1
regulation of metabolic process (GO:0019222) 1.0212ADRB2, NR0B2, CARTPT, ADRB3, MC4R, ENPP1, POMC, SIM1, GHRL, PPARGC1B, PPARG, UCP1
primary metabolic process (GO:0044238) 0.6911SDC3, NR0B2, ADRB3, ENPP1, POMC, SIM1, GHRL, UCP3, PPARGC1B, PPARG, UCP1
regulation of macromolecule metabolic process (GO:0060255) 1.0811ADRB2, NR0B2, CARTPT, ADRB3, ENPP1, POMC, SIM1, GHRL, PPARGC1B, PPARG, UCP1
regulation of cellular biosynthetic process (GO:0031326) 1.3811ADRB2, NR0B2, ADRB3, MC4R, ENPP1, POMC, SIM1, GHRL, PPARGC1B, PPARG, UCP1
response to stimulus (GO:0050896) 1.2211ADRB2, NR0B2, CARTPT, ADRB3, MC4R, ENPP1, AGRP, GHRL, UCP3, PPARGC1B, PPARG
regulation of biosynthetic process (GO:0009889) 1.3711ADRB2, NR0B2, ADRB3, MC4R, ENPP1, POMC, SIM1, GHRL, PPARGC1B, PPARG, UCP1
cellular metabolic process (GO:0044237) 0.6911SDC3, NR0B2, ADRB3, MC4R, ENPP1, UCP3, SIM1, POMC, PPARGC1B, PPARG, UCP1
organic substance metabolic process (GO:0071704) 0.6311SDC3, NR0B2, ADRB3, ENPP1, POMC, SIM1, GHRL, UCP3, PPARGC1B, PPARG, UCP1
positive regulation of biological process (GO:0048518) 1.210ADRB2, NR0B2, CARTPT, MC4R, ADRB3, AGRP, GHRL, PPARGC1B, POMC, PPARG
response to chemical (GO:0042221) 1.9810ADRB2, NR0B2, ADRB3, MC4R, ENPP1, AGRP, GHRL, UCP3, PPARGC1B, PPARG
regulation of biological quality (GO:0065008) 1.6810ADRB2, NR0B2, CARTPT, ADRB3, MC4R, ENPP1, POMC, GHRL, PPARGC1B, PPARG
signal transduction (GO:0007165) 1.2810ADRB2, NR0B2, CARTPT, MC4R, ADRB3, AGRP, GHRL, PPARGC1B, POMC, PPARG
negative regulation of biological process (GO:0048519) 1.3310ADRB2, NR0B2, CARTPT, ADRB3, MC4R, ENPP1, POMC, GHRL, PPARGC1B, PPARG
developmental process (GO:0032502) 1.369ADRB2, NR0B2, ADRB3, ENPP1, UCP3, SIM1, GHRL, PPARGC1B, PPARG
single-organism metabolic process (GO:0044710) 1.639ADRB2, NR0B2, ADRB3, MC4R, ENPP1, SDC3, GHRL, UCP3, PPARG
establishment of localization (GO:0051234) 1.489ADRB2, CARTPT, ENPP1, MC4R, ADRB3, UCP3, GHRL, PPARG, UCP1
positive regulation of metabolic process (GO:0009893) 1.749ADRB2, NR0B2, CARTPT, MC4R, ADRB3, POMC, GHRL, PPARGC1B, PPARG
single-multicellular organism process (GO:0044707) 1.789ADRB2, CARTPT, MC4R, ADRB3, AGRP, SIM1, GHRL, UCP3, PPARGC1B
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.439ADRB2, NR0B2, MC4R, ADRB3, SIM1, POMC, PPARGC1B, PPARG, UCP1
multicellular organismal process (GO:0032501) 1.459ADRB2, CARTPT, MC4R, ADRB3, AGRP, SIM1, GHRL, UCP3, PPARGC1B
transport (GO:0006810) 1.519ADRB2, CARTPT, ENPP1, MC4R, ADRB3, UCP3, GHRL, PPARG, UCP1
macromolecule metabolic process (GO:0043170) 0.839SDC3, NR0B2, ENPP1, UCP3, SIM1, POMC, PPARGC1B, PPARG, UCP1
regulation of macromolecule biosynthetic process (GO:0010556) 1.439ADRB2, NR0B2, ENPP1, POMC, SIM1, GHRL, PPARGC1B, PPARG, UCP1
nitrogen compound metabolic process (GO:0006807) 1.139SDC3, NR0B2, ENPP1, UCP3, SIM1, POMC, PPARGC1B, PPARG, UCP1
regulation of nitrogen compound metabolic process (GO:0051171) 1.369ADRB2, NR0B2, MC4R, ADRB3, SIM1, POMC, PPARGC1B, PPARG, UCP1
regulation of multicellular organismal process (GO:0051239) 1.879ADRB2, CARTPT, ENPP1, MC4R, ADRB3, POMC, GHRL, PPARGC1B, PPARG
regulation of signaling (GO:0023051) 1.729ADRB2, NR0B2, CARTPT, ADRB3, ENPP1, POMC, GHRL, PPARGC1B, PPARG
localization (GO:0051179) 1.49ADRB2, CARTPT, ENPP1, MC4R, ADRB3, UCP3, GHRL, PPARG, UCP1
regulation of cell communication (GO:0010646) 1.739ADRB2, NR0B2, CARTPT, ADRB3, ENPP1, POMC, GHRL, PPARGC1B, PPARG
response to organic substance (GO:0010033) 2.29ADRB2, NR0B2, MC4R, ENPP1, AGRP, GHRL, UCP3, PPARGC1B, PPARG
positive regulation of cellular process (GO:0048522) 1.39ADRB2, NR0B2, CARTPT, MC4R, ADRB3, POMC, GHRL, PPARGC1B, PPARG
response to oxygen-containing compound (GO:1901700) 2.578ADRB2, NR0B2, MC4R, ENPP1, AGRP, UCP3, PPARGC1B, PPARG
response to endogenous stimulus (GO:0009719) 2.798ADRB2, MC4R, ENPP1, AGRP, GHRL, UCP3, PPARGC1B, PPARG
positive regulation of macromolecule metabolic process (GO:0010604) 1.818ADRB2, NR0B2, CARTPT, ADRB3, POMC, GHRL, PPARGC1B, PPARG
response to hormone (GO:0009725) 3.338ADRB2, MC4R, ENPP1, AGRP, GHRL, UCP3, PPARGC1B, PPARG
positive regulation of cellular metabolic process (GO:0031325) 1.818ADRB2, CARTPT, MC4R, ADRB3, POMC, GHRL, PPARGC1B, PPARG
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.468ADRB2, NR0B2, ENPP1, SIM1, POMC, PPARGC1B, PPARG, UCP1
single-organism developmental process (GO:0044767) 1.498ADRB2, NR0B2, ADRB3, UCP3, SIM1, GHRL, PPARGC1B, PPARG
cellular nitrogen compound metabolic process (GO:0034641) 1.228NR0B2, ENPP1, UCP3, SIM1, POMC, PPARGC1B, PPARG, UCP1
G-protein coupled receptor signaling pathway (GO:0007186) 2.648ADRB2, CARTPT, MC4R, ADRB3, POMC, GHRL, PPARG, AGRP
regulation of gene expression (GO:0010468) 1.378ADRB2, NR0B2, CARTPT, SIM1, POMC, PPARGC1B, PPARG, UCP1
negative regulation of cellular process (GO:0048523) 1.418ADRB2, NR0B2, CARTPT, ADRB3, ENPP1, GHRL, PPARGC1B, PPARG
regulation of phosphorus metabolic process (GO:0051174) 2.357ADRB2, CARTPT, ENPP1, MC4R, ADRB3, GHRL, PPARGC1B
regulation of phosphate metabolic process (GO:0019220) 2.357ADRB2, CARTPT, ENPP1, MC4R, ADRB3, GHRL, PPARGC1B
regulation of transcription, DNA-templated (GO:0006355) 1.567ADRB2, NR0B2, SIM1, POMC, PPARGC1B, PPARG, UCP1
regulation of developmental process (GO:0050793) 2.17ADRB2, CARTPT, ENPP1, ADRB3, GHRL, PPARGC1B, PPARG
regulation of transport (GO:0051049) 2.247ADRB2, NR0B2, CARTPT, ENPP1, POMC, GHRL, PPARG
response to organonitrogen compound (GO:0010243) 3.27AGRP, MC4R, ENPP1, ADRB2, UCP3, PPARGC1B, PPARG
regulation of RNA metabolic process (GO:0051252) 1.527ADRB2, NR0B2, SIM1, POMC, PPARGC1B, PPARG, UCP1
regulation of response to stimulus (GO:0048583) 1.547ADRB2, CARTPT, ENPP1, ADRB3, GHRL, PPARGC1B, PPARG
regulation of nucleic acid-templated transcription (GO:1903506) 1.557ADRB2, NR0B2, SIM1, POMC, PPARGC1B, PPARG, UCP1
homeostatic process (GO:0042592) 2.617ADRB2, CARTPT, ENPP1, ADRB3, POMC, GHRL, PPARG
regulation of signal transduction (GO:0009966) 1.847ADRB2, CARTPT, ENPP1, ADRB3, GHRL, PPARGC1B, PPARG
biosynthetic process (GO:0009058) 1.327SDC3, NR0B2, SIM1, UCP3, PPARGC1B, PPARG, UCP1
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.247ADRB2, NR0B2, SIM1, POMC, PPARGC1B, PPARG, UCP1
regulation of RNA biosynthetic process (GO:2001141) 1.557ADRB2, NR0B2, SIM1, POMC, PPARGC1B, PPARG, UCP1
organic substance biosynthetic process (GO:1901576) 1.347SDC3, NR0B2, SIM1, UCP3, PPARGC1B, PPARG, UCP1
regulation of molecular function (GO:0065009) 1.787ADRB2, NR0B2, CARTPT, ADRB3, GHRL, PPARGC1B, PPARG
regulation of localization (GO:0032879) 1.947ADRB2, NR0B2, CARTPT, ENPP1, POMC, GHRL, PPARG
macromolecule biosynthetic process (GO:0009059) 1.617SDC3, NR0B2, SIM1, UCP3, PPARGC1B, PPARG, UCP1
response to nitrogen compound (GO:1901698) 3.127ADRB2, MC4R, ENPP1, AGRP, UCP3, PPARGC1B, PPARG
positive regulation of biosynthetic process (GO:0009891) 2.296ADRB2, MC4R, ADRB3, POMC, PPARGC1B, PPARG
negative regulation of response to stimulus (GO:0048585) 2.526ADRB2, CARTPT, ENPP1, ADRB3, GHRL, PPARG
behavior (GO:0007610) 3.476ADRB2, CARTPT, MC4R, ADRB3, AGRP, GHRL
negative regulation of signaling (GO:0023057) 2.656ADRB2, CARTPT, ENPP1, ADRB3, GHRL, PPARG
positive regulation of cellular biosynthetic process (GO:0031328) 2.36ADRB2, MC4R, ADRB3, POMC, PPARGC1B, PPARG
negative regulation of cell communication (GO:0010648) 2.666ADRB2, CARTPT, ENPP1, ADRB3, GHRL, PPARG
cellular macromolecule biosynthetic process (GO:0034645) 1.666NR0B2, SIM1, UCP3, PPARGC1B, PPARG, UCP1
positive regulation of catalytic activity (GO:0043085) 2.46ADRB2, CARTPT, ADRB3, GHRL, PPARGC1B, PPARG
cellular response to stimulus (GO:0051716) 1.976ADRB2, CARTPT, ENPP1, UCP3, PPARGC1B, PPARG
cellular macromolecule metabolic process (GO:0044260) 0.936NR0B2, SIM1, UCP3, PPARGC1B, PPARG, UCP1
positive regulation of phosphorus metabolic process (GO:0010562) 2.786ADRB2, CARTPT, MC4R, ADRB3, GHRL, PPARGC1B
negative regulation of multicellular organismal process (GO:0051241) 2.846ADRB2, CARTPT, ADRB3, POMC, GHRL, PPARG
regulation of protein metabolic process (GO:0051246) 1.936ADRB2, CARTPT, ENPP1, ADRB3, GHRL, PPARG
positive regulation of molecular function (GO:0044093) 2.236ADRB2, CARTPT, ADRB3, GHRL, PPARGC1B, PPARG
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.356ADRB2, MC4R, ADRB3, POMC, PPARGC1B, PPARG
positive regulation of phosphate metabolic process (GO:0045937) 2.786ADRB2, CARTPT, MC4R, ADRB3, GHRL, PPARGC1B
regulation of catalytic activity (GO:0050790) 1.976ADRB2, CARTPT, ADRB3, GHRL, PPARGC1B, PPARG
response to stress (GO:0006950) 1.86ADRB2, CARTPT, ADRB3, UCP3, PPARGC1B, PPARG
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.296ADRB2, MC4R, ADRB3, POMC, PPARGC1B, PPARG
single-organism localization (GO:1902578) 2.096CARTPT, MC4R, UCP3, GHRL, PPARG, UCP1
regulation of phosphorylation (GO:0042325) 2.56ADRB2, CARTPT, ENPP1, ADRB3, GHRL, PPARGC1B
regulation of cellular protein metabolic process (GO:0032268) 1.996ADRB2, CARTPT, ENPP1, ADRB3, GHRL, PPARG
cellular nitrogen compound biosynthetic process (GO:0044271) 1.596NR0B2, SIM1, UCP3, PPARGC1B, PPARG, UCP1
cellular biosynthetic process (GO:0044249) 1.376NR0B2, SIM1, UCP3, PPARGC1B, PPARG, UCP1
anatomical structure development (GO:0048856) 1.586ADRB2, NR0B2, ENPP1, SIM1, GHRL, PPARG
single-organism transport (GO:0044765) 2.186CARTPT, MC4R, UCP3, GHRL, PPARG, UCP1
regulation of multicellular organismal development (GO:2000026) 2.316ADRB2, CARTPT, ENPP1, GHRL, PPARGC1B, PPARG
positive regulation of multicellular organismal process (GO:0051240) 2.496ADRB2, CARTPT, MC4R, GHRL, PPARGC1B, PPARG
feeding behavior (GO:0007631) 5.215AGRP, ADRB3, MC4R, CARTPT, GHRL
negative regulation of metabolic process (GO:0009892) 1.935PPARG, ENPP1, GHRL, NR0B2, PPARGC1B
negative regulation of biosynthetic process (GO:0009890) 2.475PPARG, GHRL, NR0B2, PPARGC1B, ENPP1
negative regulation of cellular biosynthetic process (GO:0031327) 2.495ENPP1, PPARGC1B, PPARG, GHRL, NR0B2
cell differentiation (GO:0030154) 2.145PPARG, ADRB2, ADRB3, SIM1, UCP1
positive regulation of signaling (GO:0023056) 2.415ADRB3, ADRB2, NR0B2, GHRL, CARTPT
positive regulation of gene expression (GO:0010628) 2.355NR0B2, ADRB2, POMC, PPARG, PPARGC1B
regulation of blood pressure (GO:0008217) 4.725ADRB3, ADRB2, PPARG, POMC, CARTPT
small molecule metabolic process (GO:0044281) 2.385ENPP1, UCP3, PPARG, GHRL, NR0B2
cellular response to chemical stimulus (GO:0070887) 2.575PPARGC1B, ADRB2, PPARG, UCP3, ENPP1
response to insulin (GO:0032868) 4.725ENPP1, UCP3, PPARG, MC4R, AGRP
positive regulation of cell communication (GO:0010647) 2.415ADRB3, ADRB2, NR0B2, GHRL, CARTPT
organic cyclic compound metabolic process (GO:1901360) 1.265NR0B2, PPARGC1B, PPARG, SIM1, ENPP1
hormone-mediated signaling pathway (GO:0009755) 4.665NR0B2, GHRL, PPARG, PPARGC1B, AGRP
nucleobase-containing compound metabolic process (GO:0006139) 1.355NR0B2, PPARGC1B, PPARG, SIM1, ENPP1
nucleic acid metabolic process (GO:0090304) 1.465ENPP1, PPARGC1B, NR0B2, PPARG, SIM1
negative regulation of macromolecule metabolic process (GO:0010605) 2.015ENPP1, GHRL, PPARG, PPARGC1B, NR0B2
cellular developmental process (GO:0048869) 1.825PPARG, ADRB2, ADRB3, SIM1, UCP1
regulation of growth (GO:0040008) 3.265ADRB3, ENPP1, ADRB2, PPARG, GHRL
positive regulation of protein metabolic process (GO:0051247) 2.435ADRB3, ADRB2, PPARG, GHRL, CARTPT
positive regulation of cellular protein metabolic process (GO:0032270) 2.495ADRB3, ADRB2, PPARG, GHRL, CARTPT
regulation of protein modification process (GO:0031399) 2.325ENPP1, ADRB2, ADRB3, GHRL, CARTPT
negative regulation of cellular metabolic process (GO:0031324) 2.015ENPP1, PPARGC1B, PPARG, GHRL, NR0B2
positive regulation of transport (GO:0051050) 2.95PPARG, ADRB2, NR0B2, GHRL, CARTPT
cellular aromatic compound metabolic process (GO:0006725) 1.35PPARG, PPARGC1B, NR0B2, SIM1, ENPP1
regulation of hormone levels (GO:0010817) 3.565POMC, NR0B2, MC4R, CARTPT, GHRL
cell communication (GO:0007154) 3.045ADRB3, ADRB2, PPARG, POMC, CARTPT
response to peptide hormone (GO:0043434) 4.065ENPP1, UCP3, MC4R, PPARG, AGRP
heterocycle metabolic process (GO:0046483) 1.315ENPP1, PPARGC1B, NR0B2, PPARG, SIM1
response to abiotic stimulus (GO:0009628) 2.85ADRB3, ADRB2, PPARG, AGRP, UCP3
positive regulation of phosphorylation (GO:0042327) 2.95ADRB2, ADRB3, PPARGC1B, CARTPT, GHRL
organonitrogen compound metabolic process (GO:1901564) 2.325ENPP1, POMC, UCP3, SDC3, UCP1
chemical homeostasis (GO:0048878) 2.975ENPP1, POMC, PPARG, GHRL, CARTPT
response to peptide (GO:1901652) 3.945ENPP1, UCP3, MC4R, PPARG, AGRP
regulation of protein phosphorylation (GO:0001932) 2.575ADRB3, ADRB2, ENPP1, GHRL, CARTPT
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.535NR0B2, GHRL, PPARG, PPARGC1B, ENPP1
negative regulation of growth (GO:0045926) 4.244ADRB3, ADRB2, PPARG, ENPP1
RNA biosynthetic process (GO:0032774) 1.844NR0B2, PPARGC1B, PPARG, SIM1
regulation of secretion (GO:0051046) 3.24POMC, NR0B2, GHRL, CARTPT
regulation of response to external stimulus (GO:0032101) 3.064ADRB2, PPARG, GHRL, CARTPT
positive regulation of response to stimulus (GO:0048584) 2.184ADRB2, ADRB3, GHRL, CARTPT
regulation of cellular component organization (GO:0051128) 2.014ENPP1, ADRB2, PPARG, GHRL
cell-cell signaling (GO:0007267) 3.354ADRB2, ADRB3, POMC, CARTPT
signaling (GO:0023052) 3.254ADRB2, ADRB3, POMC, CARTPT
regulation of secretion by cell (GO:1903530) 3.284POMC, NR0B2, GHRL, CARTPT
fat cell differentiation (GO:0045444) 5.024ADRB3, ADRB2, PPARG, UCP1
negative regulation of response to external stimulus (GO:0032102) 4.184ADRB2, PPARG, GHRL, CARTPT
generation of precursor metabolites and energy (GO:0006091) 4.074ENPP1, POMC, ADRB3, MC4R
organic cyclic compound biosynthetic process (GO:1901362) 1.664PPARG, PPARGC1B, NR0B2, SIM1
response to organic cyclic compound (GO:0014070) 3.074PPARGC1B, ADRB2, PPARG, UCP3
regulation of MAPK cascade (GO:0043408) 3.224ADRB2, ADRB3, GHRL, CARTPT
regulation of intracellular signal transduction (GO:1902531) 2.314ADRB2, ADRB3, GHRL, CARTPT
regulation of system process (GO:0044057) 3.534ADRB2, POMC, CARTPT, GHRL
response to lipid (GO:0033993) 3.114PPARGC1B, ADRB2, PPARG, UCP3
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.64ENPP1, PPARGC1B, NR0B2, PPARG
rhythmic process (GO:0048511) 4.024ADRB2, PPARG, AGRP, CARTPT
animal organ development (GO:0048513) 2.534NR0B2, ADRB2, PPARG, GHRL
nucleic acid-templated transcription (GO:0097659) 1.914NR0B2, PPARGC1B, PPARG, SIM1
negative regulation of molecular function (GO:0044092) 2.744ADRB3, ADRB2, NR0B2, PPARG
heterocycle biosynthetic process (GO:0018130) 1.74PPARG, PPARGC1B, NR0B2, SIM1
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.564ADRB2, POMC, PPARG, PPARGC1B
negative regulation of developmental process (GO:0051093) 3.174ADRB2, ADRB3, GHRL, CARTPT
lipid metabolic process (GO:0006629) 2.684NR0B2, UCP3, PPARG, SDC3
ion transport (GO:0006811) 2.664ENPP1, UCP3, PPARG, UCP1
organic substance transport (GO:0071702) 2.154MC4R, PPARG, GHRL, CARTPT
positive regulation of MAPK cascade (GO:0043410) 3.574ADRB2, ADRB3, GHRL, CARTPT
reproductive process (GO:0022414) 2.554ADRB2, PPARG, AGRP, GHRL
regulation of cell differentiation (GO:0045595) 2.424ENPP1, PPARGC1B, PPARG, CARTPT
regulation of hormone secretion (GO:0046883) 4.184POMC, NR0B2, GHRL, CARTPT
positive regulation of transcription, DNA-templated (GO:0045893) 2.564ADRB2, POMC, PPARG, PPARGC1B
response to temperature stimulus (GO:0009266) 4.714ADRB3, ADRB2, PPARG, UCP3
response to cold (GO:0009409) 5.94ADRB3, ADRB2, PPARG, UCP3
positive regulation of intracellular signal transduction (GO:1902533) 2.954ADRB2, ADRB3, GHRL, CARTPT
regulation of homeostatic process (GO:0032844) 3.654PPARGC1B, MC4R, CARTPT, GHRL
RNA metabolic process (GO:0016070) 1.594PPARG, PPARGC1B, NR0B2, SIM1
single organism signaling (GO:0044700) 3.254ADRB2, ADRB3, POMC, CARTPT
negative regulation of signal transduction (GO:0009968) 2.754ADRB3, ADRB2, PPARG, ENPP1
positive regulation of developmental process (GO:0051094) 2.774ADRB2, PPARG, PPARGC1B, GHRL
protein metabolic process (GO:0019538) 1.454UCP3, PPARG, POMC, UCP1
single-organism behavior (GO:0044708) 3.794ADRB2, AGRP, CARTPT, GHRL
positive regulation of protein modification process (GO:0031401) 2.74ADRB2, ADRB3, GHRL, CARTPT
positive regulation of RNA metabolic process (GO:0051254) 2.514ADRB2, POMC, PPARG, PPARGC1B
regulation of transferase activity (GO:0051338) 2.884ADRB2, PPARG, GHRL, CARTPT
positive regulation of RNA biosynthetic process (GO:1902680) 2.544ADRB2, POMC, PPARG, PPARGC1B
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.394ADRB2, POMC, PPARG, PPARGC1B
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.814ADRB2, POMC, PPARG, PPARGC1B
transcription, DNA-templated (GO:0006351) 1.914PPARG, PPARGC1B, NR0B2, SIM1
cellular response to stress (GO:0033554) 2.514ADRB2, PPARG, PPARGC1B, CARTPT
positive regulation of signal transduction (GO:0009967) 2.54ADRB2, ADRB3, GHRL, CARTPT
aromatic compound biosynthetic process (GO:0019438) 1.74PPARG, PPARGC1B, NR0B2, SIM1
nucleobase-containing compound biosynthetic process (GO:0034654) 1.724PPARG, PPARGC1B, NR0B2, SIM1
positive regulation of protein phosphorylation (GO:0001934) 2.954ADRB2, ADRB3, GHRL, CARTPT
regulation of peptide transport (GO:0090087) 4.373GHRL, NR0B2, CARTPT
positive regulation of secretion (GO:0051047) 3.853GHRL, NR0B2, CARTPT
cellular chemical homeostasis (GO:0055082) 3.43GHRL, ENPP1, CARTPT
positive regulation of homeostatic process (GO:0032846) 4.383PPARGC1B, MC4R, GHRL
negative regulation of defense response (GO:0031348) 4.753ADRB2, PPARG, GHRL
positive regulation of nucleotide metabolic process (GO:0045981) 4.853ADRB2, ADRB3, MC4R
cellular component organization or biogenesis (GO:0071840) 1.223ADRB2, PPARGC1B, GHRL
neuropeptide signaling pathway (GO:0007218) 5.133AGRP, POMC, CARTPT
regulation of inflammatory response (GO:0050727) 4.033ADRB2, PPARG, GHRL
hormone secretion (GO:0046879) 5.483MC4R, GHRL, CARTPT
regulation of cell proliferation (GO:0042127) 2.413ADRB2, PPARG, GHRL
negative regulation of transport (GO:0051051) 3.63GHRL, ENPP1, CARTPT
organ regeneration (GO:0031100) 5.33PPARG, ADRB2, NR0B2
response to corticosteroid (GO:0031960) 4.563PPARGC1B, ADRB2, UCP3
regulation of protein kinase activity (GO:0045859) 3.153ADRB2, GHRL, CARTPT
activation of protein kinase activity (GO:0032147) 4.083ADRB2, GHRL, CARTPT
regulation of peptide hormone secretion (GO:0090276) 4.413GHRL, NR0B2, CARTPT
oxidation-reduction process (GO:0055114) 2.913ADRB3, MC4R, PPARG
system process (GO:0003008) 2.33ADRB2, ADRB3, GHRL
single organism reproductive process (GO:0044702) 2.733ADRB2, PPARG, AGRP
vesicle-mediated transport (GO:0016192) 2.723ENPP1, ADRB2, ADRB3
organonitrogen compound biosynthetic process (GO:1901566) 2.853SDC3, UCP3, UCP1
positive regulation of purine nucleotide biosynthetic process (GO:1900373) 5.093ADRB2, ADRB3, MC4R
regulation of purine nucleotide biosynthetic process (GO:1900371) 4.83ADRB2, ADRB3, MC4R
positive regulation of kinase activity (GO:0033674) 3.543ADRB2, GHRL, CARTPT
response to nutrient levels (GO:0031667) 3.773UCP3, PPARG, CARTPT
negative regulation of gene expression (GO:0010629) 2.483PPARG, PPARGC1B, NR0B2
regulation of protein transport (GO:0051223) 3.123GHRL, NR0B2, CARTPT
regulation of apoptotic process (GO:0042981) 2.53ADRB2, PPARG, GHRL
peptide hormone secretion (GO:0030072) 5.693MC4R, GHRL, CARTPT
positive regulation of transferase activity (GO:0051347) 3.313ADRB2, GHRL, CARTPT
positive regulation of hydrolase activity (GO:0051345) 2.913ADRB2, PPARG, PPARGC1B
regulation of appetite (GO:0032098) 6.513GHRL, POMC, CARTPT
regulation of kinase activity (GO:0043549) 3.073ADRB2, GHRL, CARTPT
cellular component organization (GO:0016043) 1.243ADRB2, PPARGC1B, GHRL
adenylate cyclase-modulating G-protein coupled receptor signaling pathway (GO:0007188) 4.783ADRB2, ADRB3, MC4R
regulation of bone remodeling (GO:0046850) 5.943MC4R, PPARGC1B, CARTPT
regulation of immune system process (GO:0002682) 2.53PPARGC1B, PPARG, CARTPT
regulation of defense response (GO:0031347) 3.113ADRB2, PPARG, GHRL
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187) 4.63ADRB2, ADRB3, MC4R
positive regulation of cellular component organization (GO:0051130) 2.683ADRB2, PPARG, GHRL
regulation of establishment of protein localization (GO:0070201) 3.023GHRL, NR0B2, CARTPT
tissue development (GO:0009888) 3.273GHRL, ENPP1, SIM1
regulation of behavior (GO:0050795) 5.553AGRP, MC4R, GHRL
regulation of insulin secretion (GO:0050796) 4.573GHRL, NR0B2, CARTPT
regulation of hydrolase activity (GO:0051336) 2.533ADRB2, PPARG, PPARGC1B
secretion (GO:0046903) 3.383MC4R, GHRL, CARTPT
endocytosis (GO:0006897) 3.693ENPP1, ADRB2, ADRB3
regulation of lipid transport (GO:0032368) 5.213GHRL, PPARG, POMC
regulation of response to stress (GO:0080134) 2.533ADRB2, PPARG, GHRL
receptor-mediated endocytosis (GO:0006898) 4.313ENPP1, ADRB2, ADRB3
peptide metabolic process (GO:0006518) 3.443UCP3, POMC, UCP1
regulation of developmental growth (GO:0048638) 4.043ADRB2, ADRB3, GHRL
cellular response to organic substance (GO:0071310) 2.783ENPP1, UCP3, PPARG
response to estrogen (GO:0043627) 5.253ADRB2, PPARG, GHRL
peptide transport (GO:0015833) 5.443MC4R, GHRL, CARTPT
steroid hormone mediated signaling pathway (GO:0043401) 4.93NR0B2, PPARGC1B, PPARG
positive regulation of secretion by cell (GO:1903532) 3.933GHRL, NR0B2, CARTPT
regulation of protein localization (GO:0032880) 2.883GHRL, NR0B2, CARTPT
amide transport (GO:0042886) 5.193MC4R, GHRL, CARTPT
positive regulation of cAMP biosynthetic process (GO:0030819) 5.353ADRB2, ADRB3, MC4R
positive regulation of cAMP metabolic process (GO:0030816) 5.253ADRB2, ADRB3, MC4R
regulation of cAMP biosynthetic process (GO:0030817) 5.013ADRB2, ADRB3, MC4R
regulation of cAMP metabolic process (GO:0030814) 4.883ADRB2, ADRB3, MC4R
regeneration (GO:0031099) 4.73NR0B2, ADRB2, PPARG
positive regulation of nucleotide biosynthetic process (GO:0030810) 5.093ADRB2, ADRB3, MC4R
diet induced thermogenesis (GO:0002024) 7.653ADRB2, ADRB3, MC4R
cellular response to endogenous stimulus (GO:0071495) 3.333ENPP1, UCP3, PPARG
cellular response to oxygen-containing compound (GO:1901701) 3.223ENPP1, PPARGC1B, PPARG
brown fat cell differentiation (GO:0050873) 6.263ADRB2, ADRB3, UCP1
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.713NR0B2, PPARGC1B, PPARG
negative regulation of cell differentiation (GO:0045596) 3.333ENPP1, PPARG, CARTPT
cellular response to hormone stimulus (GO:0032870) 3.993ENPP1, UCP3, PPARG
negative regulation of inflammatory response (GO:0050728) 5.113ADRB2, PPARG, GHRL
negative regulation of transcription, DNA-templated (GO:0045892) 2.753NR0B2, PPARGC1B, PPARG
positive regulation of hormone secretion (GO:0046887) 4.983GHRL, NR0B2, CARTPT
regulation of cyclic nucleotide metabolic process (GO:0030799) 4.693ADRB2, ADRB3, MC4R
cellular lipid metabolic process (GO:0044255) 2.923SDC3, PPARG, UCP3
positive regulation of purine nucleotide metabolic process (GO:1900544) 4.853ADRB2, ADRB3, MC4R
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) 3.833NR0B2, PPARGC1B, PPARG
aging (GO:0007568) 4.163ADRB2, ADRB3, UCP3
regulation of nucleotide biosynthetic process (GO:0030808) 4.793ADRB2, ADRB3, MC4R
cellular amide metabolic process (GO:0043603) 3.233UCP3, POMC, UCP1
positive regulation of cyclic nucleotide biosynthetic process (GO:0030804) 5.143ADRB2, ADRB3, MC4R
negative regulation of RNA metabolic process (GO:0051253) 2.663PPARG, PPARGC1B, NR0B2
positive regulation of cyclic nucleotide metabolic process (GO:0030801) 5.053ADRB2, ADRB3, MC4R
secretion by cell (GO:0032940) 3.593MC4R, GHRL, CARTPT
regulation of cyclic nucleotide biosynthetic process (GO:0030802) 4.853ADRB2, ADRB3, MC4R
positive regulation of protein kinase activity (GO:0045860) 3.613ADRB2, GHRL, CARTPT
response to steroid hormone (GO:0048545) 4.243PPARGC1B, ADRB2, UCP3
cellular homeostasis (GO:0019725) 3.233GHRL, ENPP1, CARTPT
response to extracellular stimulus (GO:0009991) 3.713UCP3, PPARG, CARTPT
response to glucocorticoid (GO:0051384) 4.633PPARGC1B, ADRB2, UCP3
glucose homeostasis (GO:0042593) 4.63POMC, PPARG, CARTPT
multicellular organism metabolic process (GO:0044236) 5.23ADRB2, ADRB3, MC4R
regulation of cell death (GO:0010941) 2.433ADRB2, PPARG, GHRL
carbohydrate homeostasis (GO:0033500) 4.63POMC, PPARG, CARTPT
nitrogen compound transport (GO:0071705) 3.543MC4R, GHRL, CARTPT
regulation of programmed cell death (GO:0043067) 2.493ADRB2, PPARG, GHRL
response to external stimulus (GO:0009605) 2.553UCP3, PPARG, CARTPT
regulation of tissue remodeling (GO:0034103) 5.553MC4R, PPARGC1B, CARTPT
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.553PPARG, PPARGC1B, NR0B2
signal release (GO:0023061) 4.653MC4R, GHRL, CARTPT
negative regulation of RNA biosynthetic process (GO:1902679) 2.73PPARG, PPARGC1B, NR0B2
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.473PPARG, PPARGC1B, NR0B2
adaptive thermogenesis (GO:1990845) 7.533ADRB2, ADRB3, MC4R
regulation of protein secretion (GO:0050708) 3.773GHRL, NR0B2, CARTPT
adult feeding behavior (GO:0008343) 7.433AGRP, GHRL, CARTPT
response to oxygen levels (GO:0070482) 4.023ADRB2, PPARG, UCP3
adult behavior (GO:0030534) 4.793AGRP, GHRL, CARTPT
regulation of purine nucleotide metabolic process (GO:1900542) 4.413ADRB2, ADRB3, MC4R
regulation of multicellular organism growth (GO:0040014) 5.483ADRB2, ADRB3, GHRL
peptide secretion (GO:0002790) 5.673MC4R, GHRL, CARTPT
regulation of peptide secretion (GO:0002791) 4.383GHRL, NR0B2, CARTPT
regulation of bone resorption (GO:0045124) 6.23PPARGC1B, MC4R, CARTPT
hormone transport (GO:0009914) 5.333MC4R, GHRL, CARTPT
regulation of nucleotide metabolic process (GO:0006140) 4.383ADRB2, ADRB3, MC4R
positive regulation of insulin secretion (GO:0032024) 5.572GHRL, NR0B2
negative regulation of secretion (GO:0051048) 4.442GHRL, CARTPT
fatty acid metabolic process (GO:0006631) 4.032UCP3, PPARG
negative regulation of homeostatic process (GO:0032845) 4.912GHRL, CARTPT
oxoacid metabolic process (GO:0043436) 3.122UCP3, PPARG
anion transport (GO:0006820) 3.712ENPP1, PPARG
circulatory system process (GO:0003013) 4.382ADRB2, ADRB3
cell surface receptor signaling pathway (GO:0007166) 2.092ADRB2, NR0B2
regulation of steroid hormone secretion (GO:2000831) 7.022POMC, GHRL
positive regulation of bone resorption (GO:0045780) 7.162MC4R, PPARGC1B
regulation of cyclase activity (GO:0031279) 5.322ADRB2, ADRB3
peptide biosynthetic process (GO:0043043) 3.732UCP3, UCP1
positive regulation of lipid metabolic process (GO:0045834) 4.882ADRB2, PPARG
macromolecule localization (GO:0033036) 2.342MC4R, PPARG
negative regulation of tumor necrosis factor production (GO:0032720) 5.992GHRL, POMC
regulation of feeding behavior (GO:0060259) 6.642MC4R, AGRP
monocarboxylic acid metabolic process (GO:0032787) 3.572UCP3, PPARG
establishment of protein localization (GO:0045184) 2.532MC4R, PPARG
developmental process involved in reproduction (GO:0003006) 3.362GHRL, PPARG
regulation of circadian rhythm (GO:0042752) 5.092GHRL, PPARG
positive regulation of peptide hormone secretion (GO:0090277) 5.262GHRL, NR0B2
eating behavior (GO:0042755) 6.332AGRP, ADRB3
mitochondrial transport (GO:0006839) 5.022UCP3, UCP1
regulation of glycogen metabolic process (GO:0070873) 6.172POMC, ENPP1
regulation of hemopoiesis (GO:1903706) 4.02PPARGC1B, CARTPT
cellular response to extracellular stimulus (GO:0031668) 4.572PPARG, CARTPT
cellular response to nutrient levels (GO:0031669) 4.72PPARG, CARTPT
multicellular organismal homeostasis (GO:0048871) 5.072ADRB2, ADRB3
vascular process in circulatory system (GO:0003018) 4.652ADRB2, ADRB3
negative regulation of systemic arterial blood pressure (GO:0003085) 7.332ADRB2, ADRB3
regulation of G-protein coupled receptor protein signaling pathway (GO:0008277) 4.972ADRB2, ADRB3
immune system process (GO:0002376) 2.292ENPP1, PPARG
anterograde trans-synaptic signaling (GO:0098916) 3.982ADRB2, CARTPT
regulation of membrane potential (GO:0042391) 3.892ADRB2, GHRL
regulation of anatomical structure morphogenesis (GO:0022603) 2.792ADRB2, GHRL
negative regulation of binding (GO:0051100) 4.852ADRB2, ADRB3
response to reactive oxygen species (GO:0000302) 4.52UCP3, PPARGC1B
regulation of glucose metabolic process (GO:0010906) 5.082POMC, ENPP1
inorganic ion homeostasis (GO:0098771) 3.432GHRL, ENPP1
regulation of vasculature development (GO:1901342) 4.262ADRB2, GHRL
negative regulation of vasculature development (GO:1901343) 5.322ADRB2, GHRL
negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556) 5.942GHRL, POMC
regulation of tumor necrosis factor superfamily cytokine production (GO:1903555) 5.12POMC, GHRL
vasodilation (GO:0042311) 6.682ADRB2, ADRB3
positive regulation of protein transport (GO:0051222) 3.612GHRL, NR0B2
regulation of protein serine/threonine kinase activity (GO:0071900) 3.582GHRL, CARTPT
regulation of myeloid leukocyte differentiation (GO:0002761) 5.022PPARGC1B, CARTPT
negative regulation of protein binding (GO:0032091) 5.362ADRB2, ADRB3
regulation of fat cell differentiation (GO:0045598) 5.042ENPP1, PPARG
response to hypoxia (GO:0001666) 4.132ADRB2, UCP3
proton transport (GO:0015992) 4.732UCP3, UCP1
regulation of response to food (GO:0032095) 6.782GHRL, CARTPT
positive regulation of lyase activity (GO:0051349) 5.652ADRB2, ADRB3
regulation of lipid metabolic process (GO:0019216) 4.082ADRB2, PPARG
regulation of anatomical structure size (GO:0090066) 3.782ADRB2, ADRB3
positive regulation of bone remodeling (GO:0046852) 7.162PPARGC1B, MC4R
cellular response to oxygen levels (GO:0071453) 4.972ADRB2, PPARG
adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189) 5.522ADRB2, ADRB3
energy reserve metabolic process (GO:0006112) 5.442MC4R, ADRB3
negative regulation of immune system process (GO:0002683) 3.852PPARG, CARTPT
transcription initiation from RNA polymerase II promoter (GO:0006367) 4.72NR0B2, PPARG
negative regulation of developmental growth (GO:0048640) 5.252ADRB2, ADRB3
regulation of tube size (GO:0035150) 4.792ADRB2, ADRB3
hydrogen transport (GO:0006818) 4.722UCP3, UCP1
circadian rhythm (GO:0007623) 4.792AGRP, CARTPT
cation transport (GO:0006812) 3.112UCP3, UCP1
regulation of biomineral tissue development (GO:0070167) 5.412ADRB2, ENPP1
adrenergic receptor signaling pathway (GO:0071875) 6.592ADRB2, ADRB3
regulation of protein binding (GO:0043393) 4.62ADRB2, ADRB3
immune response (GO:0006955) 2.862ENPP1, PPARG
excitatory postsynaptic potential (GO:0060079) 6.432ADRB2, GHRL
regulation of postsynaptic membrane potential (GO:0060078) 5.722ADRB2, GHRL
regulation of ossification (GO:0030278) 4.532ADRB2, ENPP1
energy derivation by oxidation of organic compounds (GO:0015980) 4.932MC4R, ADRB3
positive regulation of protein secretion (GO:0050714) 4.392GHRL, NR0B2
regulation of neurological system process (GO:0031644) 5.522ADRB2, CARTPT
response to decreased oxygen levels (GO:0036293) 4.092ADRB2, UCP3
cellular response to nitrogen compound (GO:1901699) 3.792ENPP1, PPARG
regulation of lyase activity (GO:0051339) 5.32ADRB2, ADRB3
positive regulation of nervous system development (GO:0051962) 3.642GHRL, PPARG
regulation of nervous system development (GO:0051960) 3.12GHRL, PPARG
DNA-templated transcription, initiation (GO:0006352) 4.492PPARG, NR0B2
activation of adenylate cyclase activity (GO:0007190) 6.122ADRB2, ADRB3
regulation of carbohydrate metabolic process (GO:0006109) 4.572POMC, ENPP1
regulation of myeloid cell differentiation (GO:0045637) 4.562PPARGC1B, CARTPT
synaptic signaling (GO:0099536) 3.982ADRB2, CARTPT
trans-synaptic signaling (GO:0099537) 3.982ADRB2, CARTPT
positive regulation of developmental growth (GO:0048639) 4.672ADRB2, GHRL
regulation of response to nutrient levels (GO:0032107) 6.512GHRL, CARTPT
regulation of response to extracellular stimulus (GO:0032104) 6.512GHRL, CARTPT
negative regulation of cell growth (GO:0030308) 4.582ENPP1, PPARG
lipid transport (GO:0006869) 4.242GHRL, PPARG
ion homeostasis (GO:0050801) 3.422GHRL, ENPP1
regulation of MAP kinase activity (GO:0043405) 3.952GHRL, CARTPT
negative regulation of secretion by cell (GO:1903531) 4.552GHRL, CARTPT
response to purine-containing compound (GO:0014074) 4.672PPARGC1B, PPARG
positive regulation of establishment of protein localization (GO:1904951) 3.492GHRL, NR0B2
regulation of polysaccharide metabolic process (GO:0032881) 5.972POMC, ENPP1
positive regulation of cyclase activity (GO:0031281) 5.652ADRB2, ADRB3
negative regulation of protein metabolic process (GO:0051248) 2.822GHRL, ENPP1
regulation of blood vessel size (GO:0050880) 4.82ADRB2, ADRB3
cellular response to peptide hormone stimulus (GO:0071375) 4.632ENPP1, PPARG
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122NR0B2, PPARG
negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744) 6.262ADRB2, ADRB3
(GO:0002025) 8.632ADRB2, ADRB3
adenylate cyclase-activating adrenergic receptor signaling pathway (GO:0071880) 6.682ADRB2, ADRB3
monovalent inorganic cation transport (GO:0015672) 3.742UCP3, UCP1
(GO:0002029) 7.652ADRB2, ADRB3
negative regulation of peptide hormone secretion (GO:0090278) 5.882GHRL, CARTPT
negative regulation of cell proliferation (GO:0008285) 3.262GHRL, PPARG
cellular response to external stimulus (GO:0071496) 4.22PPARG, CARTPT
multicellular organismal reproductive process (GO:0048609) 3.352ADRB2, AGRP
regulation of corticosteroid hormone secretion (GO:2000846) 7.242POMC, GHRL
positive regulation of cell differentiation (GO:0045597) 3.012PPARGC1B, PPARG
regulation of cell growth (GO:0001558) 3.752ENPP1, PPARG
regulation of cellular carbohydrate metabolic process (GO:0010675) 4.812POMC, ENPP1
negative regulation of hormone secretion (GO:0046888) 5.412GHRL, CARTPT
temperature homeostasis (GO:0001659) 6.472ADRB2, ADRB3
response to oxidative stress (GO:0006979) 3.92UCP3, PPARGC1B
heat generation (GO:0031649) 8.122ADRB2, ADRB3
amide biosynthetic process (GO:0043604) 3.62UCP3, UCP1
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091) 4.292PPARGC1B, PPARG
regulation of endocrine process (GO:0044060) 5.972POMC, GHRL
organic acid metabolic process (GO:0006082) 3.012UCP3, PPARG
carbohydrate derivative metabolic process (GO:1901135) 3.072SDC3, ENPP1
regulation of binding (GO:0051098) 4.082ADRB2, ADRB3
regulation of cytokine production (GO:0001817) 3.42GHRL, POMC
cellular response to organonitrogen compound (GO:0071417) 3.872ENPP1, PPARG
(GO:0002032) 8.632ADRB2, ADRB3
negative regulation of cytokine production (GO:0001818) 4.42GHRL, POMC
negative regulation of angiogenesis (GO:0016525) 5.422ADRB2, GHRL
adaptation of signaling pathway (GO:0023058) 7.432ADRB2, ADRB3
negative regulation of blood vessel morphogenesis (GO:2000181) 5.382ADRB2, GHRL
positive regulation of growth (GO:0045927) 4.252ADRB2, GHRL
regulation of glucocorticoid secretion (GO:2000849) 7.432POMC, GHRL
carboxylic acid metabolic process (GO:0019752) 3.122UCP3, PPARG
positive regulation of cell death (GO:0010942) 3.322ADRB2, PPARG
response to starvation (GO:0042594) 4.692PPARG, CARTPT
(GO:0022401) 7.652ADRB2, ADRB3
cellular response to insulin stimulus (GO:0032869) 5.292ENPP1, PPARG
carbohydrate metabolic process (GO:0005975) 3.262GHRL, ADRB3
intracellular receptor signaling pathway (GO:0030522) 4.62PPARGC1B, PPARG
regulation of generation of precursor metabolites and energy (GO:0043467) 5.242POMC, ENPP1
regulation of adenylate cyclase activity (GO:0045761) 5.512ADRB2, ADRB3
positive regulation of adenylate cyclase activity (GO:0045762) 5.92ADRB2, ADRB3
regulation of angiogenesis (GO:0045765) 4.362ADRB2, GHRL
positive regulation of apoptotic process (GO:0043065) 3.382ADRB2, PPARG
regulation of bone mineralization (GO:0030500) 5.492ADRB2, ENPP1
positive regulation of programmed cell death (GO:0043068) 3.382ADRB2, PPARG
positive regulation of tissue remodeling (GO:0034105) 6.472PPARGC1B, MC4R
cellular protein metabolic process (GO:0044267) 1.632UCP3, UCP1
response to nutrient (GO:0007584) 4.492UCP3, PPARG
respiratory gaseous exchange (GO:0007585) 5.862ADRB2, UCP3
organic substance catabolic process (GO:1901575) 2.452SDC3, ENPP1
response to ketone (GO:1901654) 4.532ADRB2, PPARG
cellular ion homeostasis (GO:0006873) 3.572GHRL, ENPP1
chemical synaptic transmission (GO:0007268) 3.982ADRB2, CARTPT
catabolic process (GO:0009056) 2.382SDC3, ENPP1
actin filament organization (GO:0007015) 4.542PPARGC1B, GHRL
negative regulation of multicellular organism growth (GO:0040015) 7.242ADRB2, ADRB3
negative regulation of blood pressure (GO:0045776) 5.992ADRB2, ADRB3
negative regulation of peptide secretion (GO:0002792) 5.842GHRL, CARTPT
positive regulation of peptide secretion (GO:0002793) 5.222GHRL, NR0B2
translation (GO:0006412) 3.792UCP3, UCP1
regulation of tumor necrosis factor production (GO:0032680) 5.132GHRL, POMC
regulation of leukocyte differentiation (GO:1902105) 4.262PPARGC1B, CARTPT
cellular response to peptide (GO:1901653) 4.522ENPP1, PPARG
regulation of osteoclast differentiation (GO:0045670) 5.592PPARGC1B, CARTPT
negative regulation of behavior (GO:0048521) 6.92MC4R, GHRL
positive regulation of behavior (GO:0048520) 6.472AGRP, GHRL

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of peptide transport (GO:0090087) -4.370.012ADRB2, NR0B2, CARTPT, POMC, GHRL, PPARG
positive regulation of insulin secretion (GO:0032024) -5.570.013NR0B2, ADRB2, PPARG, GHRL
negative regulation of secretion (GO:0051048) -4.440.005ADRB2, NR0B2, CARTPT, POMC, GHRL, UCP1
positive regulation of homeostatic process (GO:0032846) -4.380.003ADRB2, MC4R, PPARG, PPARGC1B, POMC
behavior (GO:0007610) -3.470.029ADRB2, CARTPT, MC4R, ADRB3, SDC3, GHRL, POMC, PPARG, AGRP
mitochondrial transport (GO:0006839) -5.020.038UCP3, PPARG, POMC, UCP1
circulatory system process (GO:0003013) -4.380.03ADRB3, ADRB2, PPARG, POMC, UCP1
signal transduction (GO:0007165) -1.280.019SDC3, NR0B2, CARTPT, MC4R, ADRB3, ADRB2, SIM1, GHRL, PPARGC1B, POMC, PPARG, AGRP
temperature homeostasis (GO:0001659) -6.470.0ADRB3, ADRB2, PPARG, POMC, UCP1
sodium ion homeostasis (GO:0055078) NEW6.360.015ADRB3, POMC, PPARG
positive regulation of nucleotide metabolic process (GO:0045981) -4.850.005ADRB3, ADRB2, POMC, PPARG, MC4R
hormone-mediated signaling pathway (GO:0009755) -4.660.0ADRB2, NR0B2, ADRB3, AGRP, GHRL, POMC, PPARG
positive regulation of bone resorption (GO:0045780) -7.160.05MC4R, PPARGC1B
neuropeptide signaling pathway (GO:0007218) -5.130.0SDC3, CARTPT, MC4R, POMC, GHRL, AGRP
hormone secretion (GO:0046879) -5.480.002GHRL, POMC, PPARG, MC4R, CARTPT
rhythmic process (GO:0048511) -4.020.0ADRB2, CARTPT, MC4R, ADRB3, SDC3, SIM1, GHRL, POMC, PPARG, UCP1
diterpenoid metabolic process (GO:0016101) NEW5.170.002ADRB2, MC4R, PPARG, SDC3, POMC
regulation of feeding behavior (GO:0060259) -6.640.05MC4R, AGRP
negative regulation of transport (GO:0051051) -3.60.005ADRB2, NR0B2, CARTPT, ENPP1, POMC, GHRL, PPARG, UCP1
response to corticosteroid (GO:0031960) -4.560.006ADRB2, UCP3, SIM1, POMC, PPARGC1B, PPARG
positive regulation of feeding behavior (GO:2000253) NEW7.780.02AGRP, MC4R
activation of protein kinase activity (GO:0032147) -4.080.037ADRB2, CARTPT, POMC, GHRL, PPARG, UCP1
developmental process involved in reproduction (GO:0003006) -3.360.001ADRB2, NR0B2, MC4R, ADRB3, SDC3, GHRL, UCP3, POMC, PPARG, UCP1
regulation of peptide hormone secretion (GO:0090276) -4.410.011ADRB2, NR0B2, CARTPT, POMC, GHRL, PPARG
positive regulation of peptide hormone secretion (GO:0090277) -5.260.046NR0B2, ADRB2, PPARG, GHRL
negative regulation of homeostatic process (GO:0032845) -4.910.049ADRB2, PPARG, CARTPT
oxoacid metabolic process (GO:0043436) -3.120.001SDC3, NR0B2, MC4R, ENPP1, AGRP, SIM1, ADRB2, GHRL, UCP3, POMC, PPARG
response to peptide hormone (GO:0043434) -4.060.007SDC3, NR0B2, ADRB3, MC4R, ENPP1, AGRP, ADRB2, GHRL, UCP3, POMC, PPARG
single organism reproductive process (GO:0044702) -2.730.007ADRB2, NR0B2, MC4R, ADRB3, SDC3, GHRL, UCP3, POMC, PPARG, UCP1, AGRP
multicellular organismal homeostasis (GO:0048871) -5.070.0PPARG, ADRB2, ADRB3, POMC, UCP1
single-organism behavior (GO:0044708) -3.790.0ADRB2, CARTPT, MC4R, ADRB3, SDC3, GHRL, POMC, PPARG, AGRP
negative regulation of systemic arterial blood pressure (GO:0003085) -7.330.036ADRB2, ADRB3, POMC
positive regulation of purine nucleotide biosynthetic process (GO:1900373) -5.090.026ADRB3, ADRB2, POMC, PPARG, MC4R
chemical homeostasis (GO:0048878) -2.970.022ADRB2, NR0B2, CARTPT, ADRB3, ENPP1, AGRP, GHRL, POMC, PPARG
regulation of lipid storage (GO:0010883) NEW6.020.045POMC, PPARG, UCP1
response to hormone (GO:0009725) -3.330.0SDC3, NR0B2, ADRB3, MC4R, ENPP1, AGRP, SIM1, ADRB2, GHRL, UCP3, PPARGC1B, POMC, PPARG
response to organonitrogen compound (GO:0010243) -3.20.0SDC3, NR0B2, ADRB3, MC4R, ENPP1, ADRB2, GHRL, UCP3, PPARGC1B, POMC, PPARG, AGRP
feeding behavior (GO:0007631) -5.210.0MC4R, ADRB3, AGRP, CARTPT, GHRL
cellular response to stimulus (GO:0051716) -1.970.001SDC3, NR0B2, CARTPT, ADRB3, MC4R, ENPP1, AGRP, SIM1, ADRB2, GHRL, UCP3, PPARGC1B, POMC, PPARG
response to nutrient levels (GO:0031667) -3.770.018CARTPT, ADRB3, POMC, SIM1, GHRL, UCP3, PPARG
vasodilation (GO:0042311) -6.680.041ADRB2, ADRB3, POMC
regulation of purine nucleotide biosynthetic process (GO:1900371) -4.80.006ADRB3, ADRB2, POMC, PPARG, MC4R
peptide hormone secretion (GO:0030072) -5.690.0GHRL, POMC, PPARG, MC4R, CARTPT
regulation of appetite (GO:0032098) -6.510.0GHRL, ADRB3, POMC, CARTPT
positive regulation of bone remodeling (GO:0046852) -7.160.05PPARGC1B, MC4R
regulation of bone remodeling (GO:0046850) -5.940.004MC4R, PPARGC1B, CARTPT
regulation of multicellular organismal metabolic process (GO:0044246) NEW6.090.007ADRB3, ADRB2, PPARG, MC4R
G-protein coupled receptor signaling pathway (GO:0007186) -2.640.001ADRB2, CARTPT, MC4R, ADRB3, SDC3, GHRL, POMC, PPARG, AGRP
regulation of tube size (GO:0035150) -4.790.022ADRB3, ADRB2, PPARG, POMC
circadian rhythm (GO:0007623) -4.790.0SDC3, CARTPT, MC4R, ADRB3, POMC, SIM1, GHRL, PPARG
lipid metabolic process (GO:0006629) -2.680.043ADRB2, NR0B2, MC4R, SDC3, GHRL, UCP3, PPARGC1B, POMC, PPARG, UCP1
regulation of biosynthetic process (GO:0009889) -1.370.033ADRB2, NR0B2, ADRB3, MC4R, ENPP1, POMC, SIM1, GHRL, PPARGC1B, PPARG, UCP1
tissue development (GO:0009888) -3.270.0SDC3, NR0B2, ADRB3, MC4R, ENPP1, ADRB2, SIM1, GHRL, PPARGC1B, POMC, PPARG
regulation of behavior (GO:0050795) -5.550.0ADRB2, MC4R, SDC3, POMC, GHRL, PPARG, UCP1, AGRP
regulation of insulin secretion (GO:0050796) -4.570.005ADRB2, NR0B2, CARTPT, POMC, GHRL, PPARG
positive regulation of MAPK cascade (GO:0043410) -3.570.031ADRB2, NR0B2, ADRB3, POMC, GHRL, PPARG, UCP1
adrenergic receptor signaling pathway (GO:0071875) -6.590.05ADRB2, ADRB3
regulation of multicellular organismal process (GO:0051239) -1.870.008ADRB2, CARTPT, ENPP1, MC4R, ADRB3, POMC, GHRL, PPARGC1B, PPARG
response to temperature stimulus (GO:0009266) -4.710.029ADRB3, ADRB2, POMC, PPARG, UCP3
regulation of ossification (GO:0030278) -4.530.0SDC3, MC4R, ENPP1, ADRB2, SIM1, POMC, PPARG, UCP1
heat generation (GO:0031649) -8.120.012ADRB2, ADRB3, POMC
regulation of lipid transport (GO:0032368) -5.210.033POMC, PPARG, GHRL
response to nitrogen compound (GO:1901698) -3.120.0SDC3, NR0B2, ADRB3, MC4R, ENPP1, AGRP, ADRB2, GHRL, UCP3, PPARGC1B, POMC, PPARG
activation of adenylate cyclase activity (GO:0007190) -6.120.019ADRB2, ADRB3, POMC
positive regulation of multicellular organismal process (GO:0051240) -2.490.004ADRB2, CARTPT, MC4R, ADRB3, SDC3, GHRL, PPARGC1B, POMC, PPARG, UCP1
endoderm development (GO:0007492) NEW6.430.027PPARG, SDC3, NR0B2
peptide transport (GO:0015833) -5.440.0ADRB2, CARTPT, MC4R, POMC, GHRL, PPARG
response to light stimulus (GO:0009416) NEW4.080.023ADRB2, MC4R, SDC3, POMC, GHRL, PPARG, AGRP
regulation of signaling (GO:0023051) -1.720.031ADRB2, NR0B2, CARTPT, ADRB3, ENPP1, POMC, GHRL, PPARGC1B, PPARG
regulation of cell communication (GO:0010646) -1.730.032ADRB2, NR0B2, CARTPT, ADRB3, ENPP1, POMC, GHRL, PPARGC1B, PPARG
response to organic cyclic compound (GO:0014070) -3.070.005ADRB2, NR0B2, ADRB3, POMC, SIM1, GHRL, UCP3, PPARGC1B, PPARG, UCP1
regulation of MAPK cascade (GO:0043408) -3.220.031ADRB2, NR0B2, CARTPT, ADRB3, POMC, GHRL, PPARG, UCP1
response to endogenous stimulus (GO:0009719) -2.790.002AGRP, NR0B2, MC4R, ENPP1, UCP3, GHRL, PPARGC1B, PPARG
amide transport (GO:0042886) -5.190.0ADRB2, CARTPT, MC4R, POMC, GHRL, PPARG
regulation of blood vessel size (GO:0050880) -4.80.017ADRB3, ADRB2, PPARG, POMC
cellular response to peptide hormone stimulus (GO:0071375) -4.630.04ADRB2, NR0B2, ENPP1, ADRB3, POMC, PPARG
positive regulation of cAMP biosynthetic process (GO:0030819) -5.350.016ADRB2, ADRB3, MC4R
positive regulation of cAMP metabolic process (GO:0030816) -5.250.022ADRB2, POMC, ADRB3, MC4R
regulation of cAMP biosynthetic process (GO:0030817) -5.010.035ADRB2, POMC, ADRB3, MC4R
positive regulation of phosphorus metabolic process (GO:0010562) -2.780.034ADRB2, NR0B2, CARTPT, MC4R, ADRB3, AGRP, GHRL, PPARGC1B, POMC, PPARG, UCP1
negative regulation of multicellular organismal process (GO:0051241) -2.840.0ADRB2, CARTPT, ADRB3, MC4R, ENPP1, SDC3, SIM1, GHRL, POMC, PPARG, UCP1
positive regulation of nucleotide biosynthetic process (GO:0030810) -5.090.026ADRB3, ADRB2, POMC, PPARG, MC4R
diet induced thermogenesis (GO:0002024) -7.650.0ADRB2, ADRB3, MC4R
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure (GO:0002025) -8.630.004ADRB2, ADRB3
cellular response to endogenous stimulus (GO:0071495) -3.330.0SDC3, NR0B2, ADRB3, MC4R, ENPP1, AGRP, ADRB2, GHRL, UCP3, POMC, PPARG, UCP1
regulation of glucocorticoid secretion (GO:2000849) -7.430.025POMC, GHRL
reproductive structure development (GO:0048608) NEW4.080.01SDC3, MC4R, ADRB3, ADRB2, POMC, PPARG, UCP1
multicellular organismal reproductive process (GO:0048609) -3.350.009ADRB2, NR0B2, MC4R, SDC3, GHRL, POMC, PPARG, UCP1, AGRP
terpenoid metabolic process (GO:0006721) NEW5.070.003ADRB2, MC4R, PPARG, SDC3, POMC
isoprenoid metabolic process (GO:0006720) NEW4.890.007ADRB2, MC4R, PPARG, SDC3, POMC
brown fat cell differentiation (GO:0050873) -6.260.001PPARG, ADRB2, ADRB3, UCP1
regulation of corticosteroid hormone secretion (GO:2000846) -7.240.036POMC, GHRL
cellular response to hormone stimulus (GO:0032870) -3.990.001SDC3, NR0B2, ADRB3, MC4R, ENPP1, AGRP, ADRB2, GHRL, UCP3, POMC, PPARG
regulation of hormone secretion (GO:0046883) -4.180.027ADRB2, NR0B2, CARTPT, POMC, GHRL, PPARG
positive regulation of hormone secretion (GO:0046887) -4.980.004PPARG, ADRB2, NR0B2, GHRL, CARTPT
response to cold (GO:0009409) -5.90.0ADRB3, ADRB2, POMC, PPARG, UCP3
carbohydrate metabolic process (GO:0005975) -3.260.01ADRB2, NR0B2, MC4R, ADRB3, SDC3, GHRL, POMC, PPARG, UCP1
positive regulation of multicellular organismal metabolic process (GO:0044253) NEW6.590.002ADRB2, ADRB3, MC4R
positive regulation of purine nucleotide metabolic process (GO:1900544) -4.850.005ADRB3, ADRB2, POMC, PPARG, MC4R
regulation of nucleotide biosynthetic process (GO:0030808) -4.790.006ADRB3, ADRB2, POMC, PPARG, MC4R
organic acid metabolic process (GO:0006082) -3.010.001SDC3, NR0B2, MC4R, ENPP1, AGRP, SIM1, ADRB2, GHRL, UCP3, POMC, PPARG
positive regulation of cyclic nucleotide biosynthetic process (GO:0030804) -5.140.017ADRB2, POMC, ADRB3, MC4R
positive regulation of cyclic nucleotide metabolic process (GO:0030801) -5.050.034ADRB2, POMC, ADRB3, MC4R
glucose metabolic process (GO:0006006) NEW4.940.019NR0B2, POMC, PPARG, GHRL, UCP1
response to stimulus (GO:0050896) -1.220.017SDC3, NR0B2, CARTPT, ADRB3, MC4R, ENPP1, AGRP, SIM1, ADRB2, GHRL, UCP3, PPARGC1B, POMC, PPARG
response to steroid hormone (GO:0048545) -4.240.007ADRB2, NR0B2, ADRB3, POMC, SIM1, GHRL, UCP3, PPARGC1B, PPARG
response to extracellular stimulus (GO:0009991) -3.710.029CARTPT, ADRB3, POMC, SIM1, GHRL, UCP3, PPARG
response to glucocorticoid (GO:0051384) -4.630.003ADRB2, UCP3, SIM1, POMC, PPARGC1B, PPARG
negative regulation of growth (GO:0045926) -4.240.018ADRB3, ADRB2, PPARG, ENPP1
regulation of cellular biosynthetic process (GO:0031326) -1.380.03ADRB2, NR0B2, ADRB3, MC4R, ENPP1, POMC, SIM1, GHRL, PPARGC1B, PPARG, UCP1
homeostatic process (GO:0042592) -2.610.009ADRB2, CARTPT, ENPP1, ADRB3, POMC, GHRL, PPARG
glucose homeostasis (GO:0042593) -4.60.002ADRB2, NR0B2, CARTPT, ADRB3, POMC, PPARG
regulation of blood pressure (GO:0008217) -4.720.0ADRB3, ADRB2, PPARG, POMC, CARTPT
response to insulin (GO:0032868) -4.720.0ADRB2, NR0B2, MC4R, ENPP1, AGRP, GHRL, UCP3, POMC, PPARG
fat cell differentiation (GO:0045444) -5.020.008ADRB3, ADRB2, PPARG, MC4R, UCP1
generation of precursor metabolites and energy (GO:0006091) -4.070.001ADRB2, ENPP1, MC4R, ADRB3, UCP3, POMC, PPARG, UCP1
response to lipid (GO:0033993) -3.110.031ADRB2, NR0B2, ADRB3, POMC, SIM1, GHRL, UCP3, PPARGC1B, PPARG
carbohydrate homeostasis (GO:0033500) -4.60.002ADRB2, NR0B2, CARTPT, ADRB3, POMC, PPARG
regulation of tissue remodeling (GO:0034103) -5.550.012MC4R, PPARG, PPARGC1B, CARTPT
positive regulation of phosphate metabolic process (GO:0045937) -2.780.034ADRB2, NR0B2, CARTPT, MC4R, ADRB3, AGRP, GHRL, PPARGC1B, POMC, PPARG, UCP1
signal release (GO:0023061) -4.650.028POMC, PPARG, MC4R, CARTPT, GHRL
regulation of hormone levels (GO:0010817) -3.560.0ADRB2, NR0B2, CARTPT, MC4R, ADRB3, POMC, GHRL, PPARG
regulation of growth hormone secretion (GO:0060123) NEW7.240.001ADRB2, POMC, GHRL
response to estrogen (GO:0043627) -5.250.006ADRB2, ADRB3, POMC, SIM1, GHRL, PPARG
adult feeding behavior (GO:0008343) -7.430.001AGRP, GHRL, CARTPT
response to oxygen-containing compound (GO:1901700) -2.570.014AGRP, NR0B2, MC4R, ENPP1, UCP3, PPARGC1B, PPARG
adult behavior (GO:0030534) -4.790.0SDC3, CARTPT, MC4R, ADRB3, AGRP, GHRL, PPARG
negative regulation of multicellular organism growth (GO:0040015) -7.240.043ADRB2, ADRB3
regulation of multicellular organism growth (GO:0040014) -5.480.021ADRB3, ADRB2, PPARG, GHRL
peptide secretion (GO:0002790) -5.670.01POMC, PPARG, MC4R, CARTPT, GHRL
regulation of peptide secretion (GO:0002791) -4.380.012ADRB2, NR0B2, CARTPT, POMC, GHRL, PPARG
regulation of bone resorption (GO:0045124) -6.20.002PPARGC1B, MC4R, CARTPT
hormone transport (GO:0009914) -5.330.025GHRL, POMC, PPARG, MC4R, CARTPT
response to peptide (GO:1901652) -3.940.009SDC3, NR0B2, ADRB3, MC4R, ENPP1, AGRP, ADRB2, GHRL, UCP3, POMC, PPARG
regulation of osteoclast differentiation (GO:0045670) -5.590.011PPARGC1B, PPARG, POMC, CARTPT
positive regulation of behavior (GO:0048520) -6.470.018POMC, PPARG, AGRP, UCP1, GHRL
eating behavior (GO:0042755) -6.330.023MC4R, ADRB3, AGRP
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.2815SDC3, NR0B2, CARTPT, ADRB3, MC4R, ENPP1, AGRP, SIM1, ADRB2, GHRL, UCP3, PPARGC1B, POMC, PPARG, UCP1
cell part (GO:0044464) 0.1115SDC3, NR0B2, CARTPT, ADRB3, MC4R, ENPP1, ADRB2, SIM1, GHRL, UCP3, PPARGC1B, POMC, PPARG, UCP1, AGRP
intracellular organelle (GO:0043229) 0.5112AGRP, NR0B2, CARTPT, MC4R, ADRB3, ADRB2, SIM1, POMC, UCP3, PPARGC1B, PPARG, UCP1
membrane-bounded organelle (GO:0043227) 0.4712AGRP, NR0B2, CARTPT, MC4R, ADRB3, ADRB2, SIM1, POMC, UCP3, PPARGC1B, PPARG, UCP1
intracellular membrane-bounded organelle (GO:0043231) 0.612AGRP, NR0B2, CARTPT, MC4R, ADRB3, ADRB2, SIM1, POMC, UCP3, PPARGC1B, PPARG, UCP1
organelle (GO:0043226) 0.412AGRP, NR0B2, CARTPT, MC4R, ADRB3, ADRB2, SIM1, POMC, UCP3, PPARGC1B, PPARG, UCP1
cytoplasmic part (GO:0044444) 0.8211ADRB2, CARTPT, ENPP1, SDC3, GHRL, UCP3, PPARGC1B, POMC, PPARG, UCP1, AGRP
intracellular organelle part (GO:0044446) 0.8110SDC3, NR0B2, ENPP1, AGRP, GHRL, UCP3, PPARGC1B, POMC, PPARG, UCP1
organelle part (GO:0044422) 0.7910SDC3, NR0B2, ENPP1, AGRP, GHRL, UCP3, PPARGC1B, POMC, PPARG, UCP1
membrane part (GO:0044425) 0.957SDC3, ENPP1, MC4R, ADRB3, ADRB2, UCP3, UCP1
integral component of membrane (GO:0016021) 1.147SDC3, ENPP1, MC4R, ADRB3, ADRB2, UCP3, UCP1
membrane (GO:0016020) 0.687SDC3, ENPP1, MC4R, ADRB3, ADRB2, UCP3, UCP1
nucleus (GO:0005634) 1.077ADRB2, NR0B2, MC4R, ADRB3, SIM1, PPARGC1B, PPARG
intrinsic component of membrane (GO:0031224) 1.137SDC3, ENPP1, MC4R, ADRB3, ADRB2, UCP3, UCP1
protein complex (GO:0043234) 1.516ADRB2, NR0B2, ADRB3, SDC3, PPARGC1B, PPARG
macromolecular complex (GO:0032991) 1.356ADRB2, NR0B2, ADRB3, SDC3, PPARGC1B, PPARG
cytoplasm (GO:0005737) 1.015NR0B2, ADRB2, POMC, PPARG, GHRL
extracellular region (GO:0005576) 2.185GHRL, POMC, ENPP1, AGRP, CARTPT
extracellular region part (GO:0044421) 1.575POMC, ENPP1, AGRP, CARTPT, GHRL
plasma membrane (GO:0005886) 1.395ENPP1, ADRB2, SDC3, ADRB3, MC4R
extracellular space (GO:0005615) 2.635GHRL, POMC, ENPP1, AGRP, CARTPT
neuron part (GO:0097458) 2.644ADRB2, SDC3, GHRL, AGRP
intracellular organelle lumen (GO:0070013) 3.054GHRL, POMC, SDC3, AGRP
membrane-enclosed lumen (GO:0031974) 3.054GHRL, POMC, SDC3, AGRP
organelle lumen (GO:0043233) 3.054GHRL, POMC, SDC3, AGRP
integral component of plasma membrane (GO:0005887) 2.573ENPP1, ADRB2, ADRB3
vesicle (GO:0031982) 1.643AGRP, POMC, CARTPT
plasma membrane part (GO:0044459) 1.953ENPP1, ADRB2, ADRB3
mitochondrion (GO:0005739) 2.423UCP3, PPARGC1B, UCP1
membrane-bounded vesicle (GO:0031988) 1.713AGRP, POMC, CARTPT
nucleoplasm (GO:0005654) 1.893PPARG, PPARGC1B, NR0B2
nuclear part (GO:0044428) 1.553NR0B2, PPARGC1B, PPARG
neuron projection (GO:0043005) 3.123ADRB2, SDC3, GHRL
axon (GO:0030424) 4.153ADRB2, SDC3, GHRL
cell projection (GO:0042995) 2.473ADRB2, SDC3, GHRL
intrinsic component of plasma membrane (GO:0031226) 2.533ENPP1, ADRB2, ADRB3
organelle membrane (GO:0031090) 1.973UCP3, ENPP1, UCP1
plasma membrane region (GO:0098590) 2.972ADRB2, ENPP1
cytoplasmic membrane-bounded vesicle lumen (GO:0060205) 5.192GHRL, POMC
vesicle lumen (GO:0031983) 5.172GHRL, POMC
cytoplasmic, membrane-bounded vesicle (GO:0016023) 3.122POMC, CARTPT
cytoplasmic vesicle (GO:0031410) 2.872POMC, CARTPT
cytoplasmic vesicle part (GO:0044433) 3.412POMC, GHRL
Golgi apparatus part (GO:0044431) 3.02SDC3, AGRP
synapse part (GO:0044456) 3.422ADRB2, GHRL
vacuolar part (GO:0044437) 3.262SDC3, ENPP1
Golgi apparatus (GO:0005794) 2.72AGRP, PPARG
Golgi lumen (GO:0005796) 5.282SDC3, AGRP
secretory vesicle (GO:0099503) 4.02POMC, CARTPT
secretory granule (GO:0030141) 4.342POMC, CARTPT
cell surface (GO:0009986) 3.442SDC3, ENPP1
mitochondrial membrane (GO:0031966) 3.312UCP3, UCP1
intracellular vesicle (GO:0097708) 2.862POMC, CARTPT
secretory granule lumen (GO:0034774) 5.382POMC, GHRL
receptor complex (GO:0043235) 4.012ADRB2, ADRB3
cytosol (GO:0005829) 1.682GHRL, PPARG
organelle inner membrane (GO:0019866) 3.562UCP3, UCP1
mitochondrial inner membrane (GO:0005743) 3.652UCP3, UCP1
postsynapse (GO:0098794) 4.872ADRB2, GHRL
mitochondrial part (GO:0044429) 2.922UCP3, UCP1

NET-GE enrichment

Term New enriched termICP valueGenes
cytoplasmic vesicle part (GO:0044433) -3.410.047ADRB2, SDC3, POMC, GHRL, UCP3, PPARG, UCP1
endoplasmic reticulum part (GO:0044432) NEW2.730.015ADRB2, NR0B2, MC4R, SDC3, POMC, GHRL, UCP3, PPARG, UCP1
extracellular space (GO:0005615) -2.630.016ADRB2, CARTPT, ADRB3, MC4R, ENPP1, SDC3, GHRL, POMC, PPARG, AGRP
integral component of plasma membrane (GO:0005887) -2.570.047ADRB2, NR0B2, ADRB3, MC4R, ENPP1, SDC3, GHRL, POMC, PPARG