Disease table of ASTHMA, SUSCEPTIBILITY TO OMIM ID: 600807

Gene-disease associations table

Gene	Associated with ASTHMA, SUSCEPTIBILITY TO in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
CCL11	ClinVar, OMIM	HGNC link	17q12	2	600807, 609423
PHF11	OMIM	HGNC link	13q14.2	2	147050, 600807
MUC7	OMIM	HGNC link	4q13.3	1	600807
ALOX5	OMIM	HGNC link	10q11.21	1	600807
IL13	ClinVar, OMIM	HGNC link	5q31.1	2	607154, 600807
HLA-G	OMIM	HGNC link	6p22.1	1	600807
SCGB3A2	ClinVar, OMIM	HGNC link	5q32	1	600807
PLA2G7	OMIM	HGNC link	6p12.3	3	600807, 147050, 614278
ADRB2	OMIM	HGNC link	5q32	2	600807, 601665
TNF	ClinVar, OMIM	HGNC link	6p21.33	3	611162, 600807, 157300
SPINK5	ClinVar	HGNC link	5q32	3	256500, 600807, 147050
SCGB1A1	ClinVar	HGNC link	11q12.3	1	600807
HNMT	ClinVar, OMIM	HGNC link	2q22.1	2	PS249500, 600807

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
5q32	3	ADRB2, SPINK5, SCGB3A2

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
5q32	3	ADRB2, SPINK5, SCGB3A2

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
6p2	2	HLA-G, TNF
5q3	4	ADRB2, SCGB3A2, IL13, SPINK5

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
5q	4	ADRB2, SCGB3A2, IL13, SPINK5
6p	3	PLA2G7, HLA-G, TNF

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
5	4	ADRB2, SCGB3A2, IL13, SPINK5
6	3	PLA2G7, HLA-G, TNF

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
HSF1	NO	26	GUCA2B, MAP3K14, STIP1, HSPA4, HSPA1A, SERPINE1, UBB, MICA, ABCB1, LDHA, TNF, BAG3, IL1B, HLA-G, CDKN1A, NAT1, HOPX, RELA, NFKB1, MICB, FKBP4, HSPA1B, SESN3, POLK, HSD17B6, ATG7	2	TNF, HLA-G
HDAC3	NO	19	TNF, GAS2, LGALS9, ATF2, CXCR4, JUN, ALOX5, CDH1, MMP2, PRAM1, ULBP1, GCM1, EGFR, LSS, IFNA1, CDKN2A, GTF2I, MYC, CDKN1B	2	TNF, ALOX5
STAT6	NO	38	BCL2L1, CCL11, CYP2E1, ORMDL3, ALOX15, ITGA2B, ADRA2B, EGLN3, FOS, IL13, PTGS2, SELE, EGR1, ALOX12, NCOA3, SOCS1, CYSLTR1, STAT1, SIDT1, CCL26, COL1A2, HSD3B2, FOSB, CNR1, CISH, SELP, OPRM1, CXCL8, CD40, DUSP1, IL24, FCER2, IRF4, IL1R1, CCL17, IL4, RHOA, COL1A1	2	IL13, CCL11
EGR1	NO	90	ATF3, PTEN, IFNG, EGFR, PDGFB, RAG2, SLC9A3, IMPDH2, SYN1, TP53, FCER2, IL2, SYN2, FAP, CHGA, GGPS1, PSEN2, SOX18, AR, GDF15, SLC4A2, LMTK2, TFPI2, MYB, TMPO, POR, FGF2, PTP4A1, PTGS2, CCND2, IL2RB, TNF, PCSK2, ALOX5, HSD11B2, ACHE, TNFSF10, TOE1, DMRT1, LHB, F3, ABCB1, STMN1, PLAUR, BCAR1, TP73, HIF1A, TGFBR2, ID3, AKR1B1, RBL2, TBXA2R, HYAL1, CACNA1H, LTB, CDK5R1, CD28, TCF4, CCND1, LDLR, MMP14, KLK3, GDNF, EAPP, PTGES, STIM1, SPRY1, VEGFA, EP300, CXCL8, NAB2, IGF2, FLT1, PDGFC, HPSE, WNT4, FN1, PLAU, ACE, UBE2S, FAS, CYP2B6, CDKN1A, SOD1, FASLG, NFKB1, IL3, IL6, LAT, PPARG	2	TNF, ALOX5
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	3	TNF, CCL11, ALOX5
CEBPB	NO	60	GADD45G, BCL2L1, IRF4, GOT1, PRL, DDIT3, CDKN1A, SMAD4, S100A9, SAA2, PTPN13, MMP1, F8, IL5RA, TFF3, ADM, CYP19A1, INSR, SFTPD, IL6, STAR, TNF, SMAD3, PCK2, IL1B, GNLY, FURIN, SAA1, SLC19A1, PTGS2, XBP1, HSF1, PRDM1, TNFAIP6, HP, IL24, IL10, SLC10A1, DAPK1, CSH2, OXTR, IL13, MAD1L1, CRP, CXCL8, SLC5A8, CSH1, HBB, ASNS, ALB, CSF3R, IL5, IL3, PRSS50, ABCB1, TOP1, GFER, IL4, CSRP1, FASLG	2	TNF, IL13
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	3	TNF, HLA-G, ALOX5
RELA	NO	302	NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC6	3	TNF, CCL11, ALOX5

regulated gene	associated to this disease	# TFs	TFs
CCL11	YES	4	STAT6, STAT3, NFKB1, RELA
ALOX5	YES	10	SP1, MBD2, EGR1, MBD1, HDAC2, MECP2, HDAC3, TP53, RELA, NFKB1
IL13	YES	6	E2F6, LEF1, CEBPB, TBX21, STAT6, AHR
HLA-G	YES	7	SP1, HSF1, IRF1, HIVEP2, CIITA, MYC, MYCN
ADRB2	YES	1	EZH2
TNF	YES	21	SP1, HMGB2, ETV4, NFAT5, SPI1, HSF1, HDAC11, RELA, JUN, IRF5, EGR1, CEBPB, HDAC3, NR4A1, ATF2, AR, LRRFIP1, CEBPD, E2F1, NFKB1, SIRT1

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
ALOX5	ADRB2	No	2	GRB2, REL
HLA-G	ADRB2	No	1	HLA-C
ADRB2	TNF	No	5	SEC61A1, UBC, CAPNS1, RAB18, TMEM259

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
CCL11	ALOX5	No	-	1	SRC
CCL11	IL13	Yes	activation, binding	4	IL9, EZR, STAT6, IL4
CCL11	SCGB3A2	No	-	1	OSM
CCL11	ADRB2	Yes	binding	26	GNG2, AGT, EZR, PRKAR2A, CFTR, ARRB1, CCR5, ADRBK1, GNGT1, GNB1, CHRM1, F2, PRKAR2B, PRKAR1A, PRKACG, PTGER1, SRC, P2RY2, EDN1, SLC9A3R1, ADRA1B, GNAS, PRKAR1B, PRKACB, CCR3, CXCL12
MUC7	IL13	No	-	2	MUC2, MUC5AC
ALOX5	IL13	No	-	2	IL6, CSF2
ALOX5	ADRB2	No	-	1	SRC
IL13	ADRB2	No	-	2	EZR, CCL11

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Cytokine-cytokine receptor interaction	hsa04060	4.67	3	TNF, IL13, CCL11
Asthma	hsa05310	7.34	3	TNF, IL13, CCL11
Salivary secretion	hsa04970	6.23	2	ADRB2, MUC7
Antigen processing and presentation	hsa04612	6.04	2	TNF, HLA-G
Natural killer cell mediated cytotoxicity	hsa04650	5.53	2	TNF, HLA-G
Metabolic pathways	hsa01100	2.49	2	PLA2G7, ALOX5
Inflammatory bowel disease (IBD)	hsa05321	6.43	2	TNF, IL13
Allograft rejection	hsa05330	6.91	2	TNF, HLA-G
Graft-versus-host disease	hsa05332	6.84	2	TNF, HLA-G
Herpes simplex infection	hsa05168	5.08	2	TNF, HLA-G
Endocytosis	hsa04144	4.92	2	ADRB2, HLA-G
Toxoplasmosis	hsa05145	5.71	2	TNF, ALOX5
Type I diabetes mellitus	hsa04940	6.79	2	TNF, HLA-G
HTLV-I infection	hsa05166	4.59	2	TNF, HLA-G
Fc epsilon RI signaling pathway	hsa04664	6.6	2	TNF, IL13

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Salivary secretion (hsa04970)	-	6.23	0.009	TNF, IL13, ADRB2, MUC7
Immune diseases	NEW	4.47	0.04	TNF, IL13, CCL11, HLA-G
Fc epsilon RI signaling pathway (hsa04664)	-	6.6	0.047	TNF, IL13, ADRB2
Asthma (hsa05310)	-	7.34	0.002	TNF, IL13, CCL11

REACTOME pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Signal Transduction	R-HSA-162582	1.78	3	TNF, ADRB2, CCL11
Signaling by GPCR	R-HSA-372790	2.68	2	ADRB2, CCL11
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	4.69	2	ADRB2, CCL11
Immune System	R-HSA-168256	2.37	2	TNF, HLA-G
Metabolism of proteins	R-HSA-392499	3.41	2	PLA2G7, MUC7
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	2	TNF, HLA-G
GPCR ligand binding	R-HSA-500792	4.19	2	ADRB2, CCL11

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	10	SCGB1A1, ADRB2, CCL11, ALOX5, TNF, MUC7, PHF11, IL13, PLA2G7, HLA-G
protein binding (GO:0005515)	0.46	8	SCGB1A1, ADRB2, CCL11, MUC7, TNF, ALOX5, IL13, HLA-G
receptor binding (GO:0005102)	2.43	5	TNF, IL13, CCL11, ADRB2, HLA-G
cytokine receptor binding (GO:0005126)	4.14	3	TNF, IL13, CCL11
cytokine activity (GO:0005125)	4.34	3	TNF, IL13, CCL11
organic cyclic compound binding (GO:0097159)	1.05	3	TNF, SCGB1A1, ADRB2
catalytic activity (GO:0003824)	1.05	3	PLA2G7, HNMT, ALOX5
molecular function regulator (GO:0098772)	2.51	3	SCGB1A1, SPINK5, ADRB2
identical protein binding (GO:0042802)	2.63	3	TNF, ADRB2, HLA-G
cation binding (GO:0043169)	1.4	2	PHF11, ALOX5
transition metal ion binding (GO:0046914)	2.48	2	PHF11, ALOX5
enzyme regulator activity (GO:0030234)	2.85	2	SCGB1A1, SPINK5
enzyme binding (GO:0019899)	2.27	2	TNF, ADRB2
ion binding (GO:0043167)	1.36	2	PHF11, ALOX5
G-protein coupled receptor binding (GO:0001664)	4.18	2	ADRB2, CCL11
enzyme inhibitor activity (GO:0004857)	3.78	2	SCGB1A1, SPINK5
metal ion binding (GO:0046872)	1.41	2	PHF11, ALOX5
protein dimerization activity (GO:0046983)	2.72	2	ADRB2, HLA-G
protein homodimerization activity (GO:0042803)	3.16	2	ADRB2, HLA-G

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
cytokine receptor binding (GO:0005126)	-	4.14	0.032	TNF, IL13, CCL11
cytokine activity (GO:0005125)	-	4.34	0.027	TNF, IL13, CCL11

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
biological regulation (GO:0065007)	0.39	11	SCGB1A1, ADRB2, CCL11, ALOX5, TNF, SPINK5, HNMT, PHF11, PLA2G7, IL13, HLA-G
regulation of biological process (GO:0050789)	0.45	11	SCGB1A1, ADRB2, CCL11, ALOX5, TNF, SPINK5, HNMT, PHF11, PLA2G7, IL13, HLA-G
cellular process (GO:0009987)	0.26	10	ADRB2, CCL11, MUC7, TNF, SPINK5, ALOX5, HNMT, PHF11, PLA2G7, IL13
single-organism process (GO:0044699)	0.48	10	SCGB1A1, ADRB2, CCL11, MUC7, TNF, SPINK5, ALOX5, HNMT, PLA2G7, IL13
regulation of cellular process (GO:0050794)	0.5	10	SCGB1A1, ADRB2, CCL11, TNF, SPINK5, HNMT, PHF11, IL13, PLA2G7, HLA-G
single-organism cellular process (GO:0044763)	0.65	9	ADRB2, CCL11, MUC7, TNF, SPINK5, ALOX5, HNMT, PLA2G7, IL13
regulation of multicellular organismal process (GO:0051239)	1.87	8	SCGB1A1, ADRB2, CCL11, ALOX5, TNF, SPINK5, IL13, HLA-G
response to stimulus (GO:0050896)	1.22	8	SCGB1A1, ADRB2, CCL11, ALOX5, TNF, HNMT, IL13, HLA-G
regulation of response to stimulus (GO:0048583)	1.54	8	SCGB1A1, ADRB2, CCL11, TNF, SPINK5, IL13, PLA2G7, HLA-G
response to stress (GO:0006950)	1.8	8	SCGB1A1, ADRB2, CCL11, ALOX5, TNF, HNMT, IL13, HLA-G
metabolic process (GO:0008152)	0.58	8	ADRB2, CCL11, MUC7, TNF, ALOX5, HNMT, PHF11, PLA2G7
positive regulation of biological process (GO:0048518)	1.2	8	ADRB2, CCL11, ALOX5, TNF, HNMT, PLA2G7, IL13, HLA-G
primary metabolic process (GO:0044238)	0.69	7	CCL11, MUC7, TNF, ALOX5, HNMT, PHF11, PLA2G7
single-organism metabolic process (GO:0044710)	1.63	7	ADRB2, CCL11, MUC7, TNF, ALOX5, HNMT, PLA2G7
multicellular organismal process (GO:0032501)	1.45	7	SCGB1A1, ADRB2, CCL11, ALOX5, TNF, HNMT, PLA2G7
regulation of primary metabolic process (GO:0080090)	1.08	7	SCGB1A1, ADRB2, CCL11, TNF, SPINK5, PHF11, IL13
regulation of metabolic process (GO:0019222)	1.02	7	SCGB1A1, ADRB2, CCL11, TNF, SPINK5, PHF11, IL13
regulation of macromolecule metabolic process (GO:0060255)	1.08	7	SCGB1A1, ADRB2, CCL11, TNF, SPINK5, PHF11, IL13
regulation of cellular metabolic process (GO:0031323)	1.07	7	SCGB1A1, ADRB2, CCL11, TNF, SPINK5, PHF11, IL13
cellular metabolic process (GO:0044237)	0.69	7	CCL11, MUC7, TNF, ALOX5, HNMT, PHF11, PLA2G7
organic substance metabolic process (GO:0071704)	0.63	7	CCL11, MUC7, TNF, ALOX5, HNMT, PHF11, PLA2G7
response to chemical (GO:0042221)	1.98	7	SCGB1A1, ADRB2, CCL11, ALOX5, TNF, HNMT, IL13
positive regulation of cellular process (GO:0048522)	1.3	7	ADRB2, CCL11, TNF, HNMT, IL13, PLA2G7, HLA-G
regulation of cell proliferation (GO:0042127)	2.41	6	SCGB1A1, ADRB2, CCL11, TNF, IL13, HLA-G
response to abiotic stimulus (GO:0009628)	2.8	6	ADRB2, CCL11, ALOX5, TNF, HNMT, IL13
negative regulation of multicellular organismal process (GO:0051241)	2.84	6	SCGB1A1, ADRB2, TNF, SPINK5, IL13, HLA-G
regulation of biological quality (GO:0065008)	1.68	6	SCGB1A1, ADRB2, CCL11, ALOX5, TNF, IL13
single-multicellular organism process (GO:0044707)	1.78	6	ADRB2, CCL11, ALOX5, TNF, HNMT, PLA2G7
regulation of response to external stimulus (GO:0032101)	3.06	6	SCGB1A1, ADRB2, CCL11, TNF, SPINK5, PLA2G7
regulation of developmental process (GO:0050793)	2.1	6	ADRB2, CCL11, TNF, SPINK5, IL13, HLA-G
positive regulation of multicellular organismal process (GO:0051240)	2.49	6	ADRB2, CCL11, ALOX5, TNF, IL13, HLA-G
regulation of catalytic activity (GO:0050790)	1.97	6	SCGB1A1, ADRB2, CCL11, TNF, SPINK5, IL13
regulation of response to stress (GO:0080134)	2.53	6	SCGB1A1, ADRB2, CCL11, TNF, SPINK5, PLA2G7
regulation of multicellular organismal development (GO:2000026)	2.31	6	ADRB2, CCL11, TNF, SPINK5, IL13, HLA-G
negative regulation of cellular process (GO:0048523)	1.41	6	SCGB1A1, ADRB2, TNF, SPINK5, IL13, HLA-G
negative regulation of biological process (GO:0048519)	1.33	6	SCGB1A1, ADRB2, TNF, SPINK5, IL13, HLA-G
regulation of immune system process (GO:0002682)	2.5	6	SCGB1A1, TNF, SPINK5, IL13, PLA2G7, HLA-G
regulation of molecular function (GO:0065009)	1.78	6	SCGB1A1, ADRB2, CCL11, TNF, SPINK5, IL13
regulation of localization (GO:0032879)	1.94	6	ADRB2, CCL11, TNF, HNMT, IL13, PLA2G7
response to organic substance (GO:0010033)	2.2	6	SCGB1A1, ADRB2, CCL11, TNF, HNMT, IL13
regulation of defense response (GO:0031347)	3.11	6	SCGB1A1, ADRB2, CCL11, TNF, SPINK5, PLA2G7
signal transduction (GO:0007165)	1.28	6	SCGB1A1, ADRB2, CCL11, TNF, IL13, HLA-G
response to oxygen-containing compound (GO:1901700)	2.57	5	TNF, SCGB1A1, IL13, ADRB2, HNMT
response to endogenous stimulus (GO:0009719)	2.79	5	SCGB1A1, TNF, ADRB2, IL13, HNMT
regulation of cellular protein metabolic process (GO:0032268)	1.99	5	TNF, IL13, SPINK5, CCL11, ADRB2
response to biotic stimulus (GO:0009607)	3.09	5	TNF, SCGB1A1, IL13, CCL11, HNMT
negative regulation of developmental process (GO:0051093)	3.17	5	TNF, SPINK5, ADRB2, IL13, HLA-G
response to external stimulus (GO:0009605)	2.55	5	SCGB1A1, TNF, IL13, CCL11, ALOX5
positive regulation of developmental process (GO:0051094)	2.77	5	TNF, IL13, CCL11, ADRB2, HLA-G
regulation of cell activation (GO:0050865)	3.53	5	SCGB1A1, IL13, SPINK5, ADRB2, HLA-G
response to lipid (GO:0033993)	3.11	5	SCGB1A1, TNF, IL13, ADRB2, HNMT
regulation of cell adhesion (GO:0030155)	3.27	5	SCGB1A1, TNF, ADRB2, SPINK5, HLA-G
positive regulation of response to stimulus (GO:0048584)	2.18	5	TNF, PLA2G7, IL13, CCL11, ADRB2
regulation of protein metabolic process (GO:0051246)	1.93	5	TNF, ADRB2, SPINK5, CCL11, IL13
regulation of inflammatory response (GO:0050727)	4.03	5	TNF, SCGB1A1, PLA2G7, CCL11, ADRB2
cellular component organization (GO:0016043)	1.24	5	TNF, PLA2G7, ADRB2, CCL11, SPINK5
macromolecule metabolic process (GO:0043170)	0.83	5	TNF, PHF11, PLA2G7, CCL11, MUC7
defense response (GO:0006952)	2.78	5	TNF, IL13, CCL11, HLA-G, ALOX5
regulation of cell-cell adhesion (GO:0022407)	3.79	5	TNF, SCGB1A1, ADRB2, SPINK5, HLA-G
cellular component organization or biogenesis (GO:0071840)	1.22	5	TNF, PLA2G7, SPINK5, CCL11, ADRB2
negative regulation of molecular function (GO:0044092)	2.74	5	TNF, SCGB1A1, IL13, ADRB2, SPINK5
response to organic cyclic compound (GO:0014070)	3.07	5	SCGB1A1, TNF, ADRB2, IL13, HNMT
developmental process (GO:0032502)	1.36	4	TNF, ADRB2, CCL11, HNMT
response to nitrogen compound (GO:1901698)	3.12	4	TNF, IL13, ADRB2, HNMT
response to glucocorticoid (GO:0051384)	4.63	4	SCGB1A1, TNF, ADRB2, HNMT
negative regulation of metabolic process (GO:0009892)	1.93	4	TNF, SCGB1A1, IL13, SPINK5
positive regulation of metabolic process (GO:0009893)	1.74	4	TNF, IL13, CCL11, ADRB2
regulation of organelle organization (GO:0033043)	2.72	4	TNF, ADRB2, CCL11, HNMT
regulation of transport (GO:0051049)	2.24	4	TNF, IL13, ADRB2, HNMT
negative regulation of response to stimulus (GO:0048585)	2.52	4	TNF, SPINK5, ADRB2, HLA-G
immune response (GO:0006955)	2.86	4	TNF, IL13, CCL11, HLA-G
regulation of cellular biosynthetic process (GO:0031326)	1.38	4	TNF, PHF11, ADRB2, SCGB1A1
regulation of cellular component organization (GO:0051128)	2.01	4	TNF, ADRB2, CCL11, HNMT
positive regulation of signaling (GO:0023056)	2.41	4	TNF, ADRB2, CCL11, IL13
positive regulation of protein phosphorylation (GO:0001934)	2.95	4	TNF, IL13, CCL11, ADRB2
cellular response to chemical stimulus (GO:0070887)	2.57	4	TNF, IL13, CCL11, ADRB2
regulation of signaling (GO:0023051)	1.72	4	TNF, ADRB2, CCL11, IL13
regulation of phosphate metabolic process (GO:0019220)	2.35	4	TNF, ADRB2, CCL11, IL13
positive regulation of cell communication (GO:0010647)	2.41	4	TNF, ADRB2, CCL11, IL13
regulation of cell communication (GO:0010646)	1.73	4	TNF, IL13, CCL11, ADRB2
negative regulation of catalytic activity (GO:0043086)	3.0	4	SCGB1A1, TNF, IL13, SPINK5
cellular response to stimulus (GO:0051716)	1.97	4	TNF, ADRB2, CCL11, IL13
regulation of lymphocyte activation (GO:0051249)	3.73	4	SCGB1A1, IL13, SPINK5, HLA-G
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	4	TNF, ADRB2, CCL11, IL13
response to external biotic stimulus (GO:0043207)	3.13	4	TNF, SCGB1A1, IL13, CCL11
regulation of transcription, DNA-templated (GO:0006355)	1.56	4	SCGB1A1, PHF11, ADRB2, TNF
regulation of signal transduction (GO:0009966)	1.84	4	TNF, IL13, CCL11, ADRB2
positive regulation of signal transduction (GO:0009967)	2.5	4	TNF, ADRB2, CCL11, IL13
cell surface receptor signaling pathway (GO:0007166)	2.09	4	TNF, ADRB2, CCL11, HLA-G
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	4	TNF, ADRB2, CCL11, SPINK5
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	4	TNF, PHF11, ADRB2, SCGB1A1
positive regulation of protein metabolic process (GO:0051247)	2.43	4	TNF, ADRB2, CCL11, IL13
regulation of cytokine production (GO:0001817)	3.4	4	SCGB1A1, TNF, IL13, HLA-G
positive regulation of immune system process (GO:0002684)	2.96	4	TNF, IL13, PLA2G7, HLA-G
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	4	TNF, IL13, CCL11, ADRB2
negative regulation of immune system process (GO:0002683)	3.85	4	TNF, SCGB1A1, SPINK5, HLA-G
regulation of protein modification process (GO:0031399)	2.32	4	TNF, ADRB2, CCL11, IL13
positive regulation of cellular metabolic process (GO:0031325)	1.81	4	TNF, ADRB2, CCL11, IL13
regulation of leukocyte cell-cell adhesion (GO:1903037)	4.01	4	SCGB1A1, TNF, SPINK5, HLA-G
positive regulation of cell proliferation (GO:0008284)	3.01	4	TNF, IL13, CCL11, ADRB2
regulation of hydrolase activity (GO:0051336)	2.53	4	TNF, ADRB2, CCL11, SPINK5
response to cytokine (GO:0034097)	3.84	4	SCGB1A1, IL13, CCL11, HNMT
positive regulation of phosphate metabolic process (GO:0045937)	2.78	4	TNF, IL13, CCL11, ADRB2
positive regulation of transport (GO:0051050)	2.9	4	TNF, ADRB2, IL13, HNMT
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	4	TNF, PHF11, ADRB2, SCGB1A1
response to corticosteroid (GO:0031960)	4.56	4	SCGB1A1, TNF, ADRB2, HNMT
regulation of biosynthetic process (GO:0009889)	1.37	4	SCGB1A1, PHF11, ADRB2, TNF
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	4	SCGB1A1, PHF11, ADRB2, TNF
single-organism developmental process (GO:0044767)	1.49	4	TNF, ADRB2, CCL11, HNMT
regulation of cell differentiation (GO:0045595)	2.42	4	TNF, SPINK5, IL13, HLA-G
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	4	TNF, PHF11, ADRB2, SCGB1A1
inflammatory response (GO:0006954)	3.64	4	TNF, IL13, CCL11, ALOX5
regulation of RNA biosynthetic process (GO:2001141)	1.55	4	TNF, PHF11, ADRB2, SCGB1A1
positive regulation of intracellular signal transduction (GO:1902533)	2.95	4	TNF, IL13, CCL11, ADRB2
regulation of intracellular signal transduction (GO:1902531)	2.31	4	TNF, ADRB2, CCL11, IL13
multi-organism process (GO:0051704)	2.65	4	TNF, SCGB1A1, ADRB2, CCL11
regulation of phosphorylation (GO:0042325)	2.5	4	TNF, ADRB2, CCL11, IL13
regulation of phosphorus metabolic process (GO:0051174)	2.35	4	TNF, ADRB2, CCL11, IL13
positive regulation of phosphorylation (GO:0042327)	2.9	4	TNF, ADRB2, CCL11, IL13
regulation of immune response (GO:0050776)	2.98	4	TNF, SPINK5, IL13, HLA-G
cellular macromolecule metabolic process (GO:0044260)	0.93	4	TNF, PHF11, CCL11, MUC7
response to hormone (GO:0009725)	3.33	4	TNF, SCGB1A1, ADRB2, HNMT
response to organonitrogen compound (GO:0010243)	3.2	4	TNF, ADRB2, IL13, HNMT
regulation of RNA metabolic process (GO:0051252)	1.52	4	TNF, PHF11, ADRB2, SCGB1A1
positive regulation of organelle organization (GO:0010638)	3.38	4	TNF, ADRB2, CCL11, HNMT
regulation of gene expression (GO:0010468)	1.37	4	SCGB1A1, PHF11, ADRB2, TNF
immune system process (GO:0002376)	2.29	4	TNF, IL13, CCL11, HLA-G
regulation of leukocyte activation (GO:0002694)	3.6	4	SCGB1A1, SPINK5, IL13, HLA-G
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	4	TNF, PHF11, ADRB2, SCGB1A1
positive regulation of protein modification process (GO:0031401)	2.7	4	TNF, IL13, CCL11, ADRB2
regulation of protein phosphorylation (GO:0001932)	2.57	4	TNF, IL13, CCL11, ADRB2
positive regulation of cellular component organization (GO:0051130)	2.68	4	TNF, ADRB2, CCL11, HNMT
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	4	TNF, IL13, CCL11, ADRB2
response to steroid hormone (GO:0048545)	4.24	4	TNF, SCGB1A1, ADRB2, HNMT
positive regulation of intracellular transport (GO:0032388)	4.08	3	TNF, IL13, HNMT
positive regulation of response to external stimulus (GO:0032103)	4.17	3	TNF, PLA2G7, CCL11
regulation of cellular localization (GO:0060341)	3.03	3	TNF, IL13, HNMT
macromolecular complex subunit organization (GO:0043933)	2.14	3	TNF, PLA2G7, ADRB2
regulation of intracellular transport (GO:0032386)	3.58	3	TNF, IL13, HNMT
negative regulation of cell activation (GO:0050866)	4.67	3	SCGB1A1, ADRB2, HLA-G
negative regulation of cellular metabolic process (GO:0031324)	2.01	3	TNF, SCGB1A1, SPINK5
positive regulation of cell migration (GO:0030335)	3.77	3	TNF, PLA2G7, CCL11
regulation of T cell activation (GO:0050863)	4.05	3	SCGB1A1, SPINK5, HLA-G
movement of cell or subcellular component (GO:0006928)	2.61	3	TNF, IL13, CCL11
positive regulation of defense response (GO:0031349)	3.83	3	TNF, PLA2G7, CCL11
negative regulation of cell adhesion (GO:0007162)	4.33	3	SCGB1A1, ADRB2, HLA-G
small molecule metabolic process (GO:0044281)	2.38	3	TNF, HNMT, ALOX5
regulation of mononuclear cell proliferation (GO:0032944)	4.45	3	SCGB1A1, IL13, HLA-G
regulation of production of molecular mediator of immune response (GO:0002700)	5.1	3	TNF, SPINK5, IL13
positive regulation of protein transport (GO:0051222)	3.61	3	TNF, IL13, HNMT
regulation of protein transport (GO:0051223)	3.12	3	TNF, IL13, HNMT
regulation of apoptotic process (GO:0042981)	2.5	3	TNF, IL13, ADRB2
response to lipopolysaccharide (GO:0032496)	4.03	3	SCGB1A1, TNF, IL13
negative regulation of cell-cell adhesion (GO:0022408)	4.84	3	SCGB1A1, ADRB2, HLA-G
regulation of protein localization (GO:0032880)	2.88	3	TNF, IL13, HNMT
cellular protein metabolic process (GO:0044267)	1.63	3	TNF, CCL11, MUC7
protein modification process (GO:0036211)	1.79	3	TNF, CCL11, MUC7
positive regulation of inflammatory response (GO:0050729)	4.98	3	TNF, PLA2G7, CCL11
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	3	SCGB1A1, TNF, SPINK5
positive regulation of hydrolase activity (GO:0051345)	2.91	3	TNF, ADRB2, CCL11
cellular developmental process (GO:0048869)	1.82	3	TNF, SPINK5, ADRB2
regulation of leukocyte proliferation (GO:0070663)	4.4	3	SCGB1A1, IL13, HLA-G
regulation of anatomical structure size (GO:0090066)	3.78	3	ADRB2, CCL11, ALOX5
regulation of leukocyte differentiation (GO:1902105)	4.26	3	TNF, SPINK5, HLA-G
cellular response to organic substance (GO:0071310)	2.78	3	TNF, IL13, CCL11
animal organ development (GO:0048513)	2.53	3	TNF, ADRB2, HNMT
positive regulation of catalytic activity (GO:0043085)	2.4	3	TNF, ADRB2, CCL11
positive regulation of molecular function (GO:0044093)	2.23	3	TNF, ADRB2, CCL11
response to molecule of bacterial origin (GO:0002237)	3.99	3	TNF, SCGB1A1, IL13
regulation of MAPK cascade (GO:0043408)	3.22	3	TNF, ADRB2, CCL11
cytokine-mediated signaling pathway (GO:0019221)	3.6	3	TNF, CCL11, HLA-G
regulation of programmed cell death (GO:0043067)	2.49	3	TNF, ADRB2, IL13
regulation of establishment of protein localization (GO:0070201)	3.02	3	TNF, IL13, HNMT
regulation of cell migration (GO:0030334)	3.23	3	TNF, PLA2G7, CCL11
biosynthetic process (GO:0009058)	1.32	3	TNF, PHF11, ALOX5
organic substance biosynthetic process (GO:1901576)	1.34	3	TNF, PHF11, ALOX5
transport (GO:0006810)	1.51	3	TNF, ADRB2, SCGB3A2
cellular protein modification process (GO:0006464)	1.79	3	TNF, CCL11, MUC7
positive regulation of MAPK cascade (GO:0043410)	3.57	3	TNF, ADRB2, CCL11
negative regulation of cell differentiation (GO:0045596)	3.33	3	TNF, IL13, HLA-G
macromolecule modification (GO:0043412)	1.73	3	TNF, CCL11, MUC7
regulation of locomotion (GO:0040012)	3.12	3	TNF, PLA2G7, CCL11
positive regulation of establishment of protein localization (GO:1904951)	3.49	3	TNF, IL13, HNMT
response to alkaloid (GO:0043279)	4.83	3	TNF, IL13, HNMT
establishment of localization (GO:0051234)	1.48	3	TNF, ADRB2, SCGB3A2
regulation of hemopoiesis (GO:1903706)	4.0	3	TNF, SPINK5, HLA-G
localization (GO:0051179)	1.4	3	TNF, ADRB2, SCGB3A2
positive regulation of cell differentiation (GO:0045597)	3.01	3	TNF, IL13, HLA-G
positive regulation of cellular component movement (GO:0051272)	3.71	3	TNF, PLA2G7, CCL11
negative regulation of immune response (GO:0050777)	4.94	3	TNF, SPINK5, HLA-G
regulation of cellular component movement (GO:0051270)	3.08	3	TNF, PLA2G7, CCL11
positive regulation of locomotion (GO:0040017)	3.71	3	TNF, PLA2G7, CCL11
protein metabolic process (GO:0019538)	1.45	3	TNF, CCL11, MUC7
regulation of angiogenesis (GO:0045765)	4.36	3	SPINK5, CCL11, ADRB2
anatomical structure development (GO:0048856)	1.58	3	TNF, ADRB2, HNMT
regulation of lymphocyte proliferation (GO:0050670)	4.46	3	SCGB1A1, IL13, HLA-G
regulation of vasculature development (GO:1901342)	4.26	3	SPINK5, CCL11, ADRB2
regulation of immune effector process (GO:0002697)	3.71	3	TNF, IL13, SPINK5
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	3	TNF, SCGB1A1, ADRB2
regulation of cell motility (GO:2000145)	3.16	3	TNF, PLA2G7, CCL11
positive regulation of cell motility (GO:2000147)	3.74	3	TNF, PLA2G7, CCL11
cell differentiation (GO:0030154)	2.14	3	TNF, SPINK5, ADRB2
regulation of cell death (GO:0010941)	2.43	3	TNF, ADRB2, IL13
negative regulation of cytokine production (GO:0001818)	4.4	3	TNF, SCGB1A1, IL13
positive regulation of cytokine production (GO:0001819)	3.82	3	TNF, IL13, HLA-G
negative regulation of T cell proliferation (GO:0042130)	5.82	2	SCGB1A1, HLA-G
regulation of intracellular protein transport (GO:0033157)	3.8	2	TNF, HNMT
regulation of secretion (GO:0051046)	3.2	2	TNF, IL13
positive regulation of secretion (GO:0051047)	3.85	2	TNF, IL13
activation of protein kinase activity (GO:0032147)	4.08	2	TNF, ADRB2
regulation of homeostatic process (GO:0032844)	3.65	2	TNF, IL13
negative regulation of defense response (GO:0031348)	4.75	2	SPINK5, ADRB2
positive regulation of leukocyte mediated immunity (GO:0002705)	5.32	2	TNF, IL13
circulatory system process (GO:0003013)	4.38	2	ADRB2, ALOX5
regulation of leukocyte mediated immunity (GO:0002703)	4.7	2	TNF, IL13
negative regulation of production of molecular mediator of immune response (GO:0002701)	6.36	2	TNF, SPINK5
vascular process in circulatory system (GO:0003018)	4.65	2	ADRB2, ALOX5
signal transduction by protein phosphorylation (GO:0023014)	3.79	2	TNF, CCL11
single-organism catabolic process (GO:0044712)	3.21	2	PLA2G7, HNMT
negative regulation of signal transduction (GO:0009968)	2.75	2	TNF, ADRB2
positive regulation of cell adhesion (GO:0045785)	3.79	2	TNF, HLA-G
response to virus (GO:0009615)	4.21	2	TNF, CCL11
MAPK cascade (GO:0000165)	3.91	2	TNF, CCL11
interspecies interaction between organisms (GO:0044419)	3.08	2	TNF, CCL11
regulation of epithelial cell differentiation (GO:0030856)	4.96	2	TNF, IL13
positive regulation of cellular catabolic process (GO:0031331)	4.15	2	TNF, ADRB2
negative regulation of cell death (GO:0060548)	2.95	2	TNF, IL13
regulation of protein kinase activity (GO:0045859)	3.15	2	TNF, ADRB2
regulation of T cell proliferation (GO:0042129)	4.74	2	SCGB1A1, HLA-G
positive regulation of homeostatic process (GO:0032846)	4.38	2	TNF, IL13
positive regulation of hemopoiesis (GO:1903708)	4.63	2	TNF, HLA-G
regulation of proteolysis (GO:0030162)	3.2	2	TNF, SPINK5
oxoacid metabolic process (GO:0043436)	3.12	2	HNMT, ALOX5
response to other organism (GO:0051707)	3.48	2	TNF, CCL11
oxidation-reduction process (GO:0055114)	2.91	2	PLA2G7, ALOX5
system process (GO:0003008)	2.3	2	ADRB2, ALOX5
single organism signaling (GO:0044700)	3.25	2	ADRB2, IL13
multi-organism reproductive process (GO:0044703)	4.82	2	SCGB1A1, ADRB2
single organism reproductive process (GO:0044702)	2.73	2	SCGB1A1, ADRB2
vesicle-mediated transport (GO:0016192)	2.72	2	ADRB2, SCGB3A2
multi-multicellular organism process (GO:0044706)	4.92	2	SCGB1A1, ADRB2
cell motility (GO:0048870)	3.02	2	TNF, CCL11
cell communication (GO:0007154)	3.04	2	ADRB2, IL13
extracellular matrix organization (GO:0030198)	4.01	2	TNF, SPINK5
cellular response to stress (GO:0033554)	2.51	2	TNF, ADRB2
female pregnancy (GO:0007565)	5.08	2	SCGB1A1, ADRB2
regulation of smooth muscle cell proliferation (GO:0048660)	5.1	2	TNF, IL13
negative regulation of cell communication (GO:0010648)	2.66	2	TNF, ADRB2
positive regulation of catabolic process (GO:0009896)	3.94	2	TNF, ADRB2
regulation of catabolic process (GO:0009894)	3.52	2	TNF, ADRB2
cellular component assembly (GO:0022607)	2.14	2	TNF, ADRB2
negative regulation of biosynthetic process (GO:0009890)	2.47	2	TNF, SCGB1A1
positive regulation of biosynthetic process (GO:0009891)	2.29	2	TNF, ADRB2
regulation of interferon-gamma production (GO:0032649)	5.21	2	SCGB1A1, TNF
chronic inflammatory response (GO:0002544)	7.16	2	TNF, CCL11
negative regulation of gene expression (GO:0010629)	2.48	2	TNF, SCGB1A1
negative regulation of vasculature development (GO:1901343)	5.32	2	ADRB2, SPINK5
positive regulation of gene expression (GO:0010628)	2.35	2	TNF, ADRB2
positive regulation of smooth muscle cell proliferation (GO:0048661)	5.6	2	TNF, IL13
negative regulation of mononuclear cell proliferation (GO:0032945)	5.59	2	SCGB1A1, HLA-G
intracellular signal transduction (GO:0035556)	2.39	2	TNF, CCL11
viral process (GO:0016032)	3.15	2	TNF, CCL11
regulation of oxidoreductase activity (GO:0051341)	5.27	2	TNF, IL13
positive regulation of transferase activity (GO:0051347)	3.31	2	TNF, ADRB2
negative regulation of hydrolase activity (GO:0051346)	3.74	2	TNF, SPINK5
positive regulation of blood circulation (GO:1903524)	5.16	2	ADRB2, ALOX5
regulation of kinase activity (GO:0043549)	3.07	2	TNF, ADRB2
macromolecular complex assembly (GO:0065003)	2.55	2	TNF, ADRB2
positive regulation of leukocyte migration (GO:0002687)	5.05	2	TNF, PLA2G7
regulation of leukocyte migration (GO:0002685)	4.72	2	TNF, PLA2G7
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	2	TNF, ADRB2
cell migration (GO:0016477)	3.12	2	TNF, CCL11
G-protein coupled receptor signaling pathway (GO:0007186)	2.64	2	ADRB2, CCL11
regulation of tube size (GO:0035150)	4.79	2	ADRB2, ALOX5
respiratory gaseous exchange (GO:0007585)	5.86	2	ADRB2, HNMT
lipid metabolic process (GO:0006629)	2.68	2	PLA2G7, ALOX5
positive regulation of intracellular protein transport (GO:0090316)	4.19	2	TNF, HNMT
regulation of multi-organism process (GO:0043900)	3.6	2	TNF, SPINK5
negative regulation of multi-organism process (GO:0043901)	4.7	2	TNF, SPINK5
regulation of blood circulation (GO:1903522)	4.05	2	ADRB2, ALOX5
single-organism carbohydrate metabolic process (GO:0044723)	3.42	2	TNF, MUC7
regulation of ossification (GO:0030278)	4.53	2	TNF, ADRB2
negative regulation of ossification (GO:0030279)	5.48	2	TNF, ADRB2
macromolecule biosynthetic process (GO:0009059)	1.61	2	TNF, PHF11
regulation of metal ion transport (GO:0010959)	3.94	2	ADRB2, IL13
positive regulation of protein kinase activity (GO:0045860)	3.61	2	TNF, ADRB2
endocytosis (GO:0006897)	3.69	2	ADRB2, SCGB3A2
intracellular transport (GO:0046907)	2.67	2	TNF, ADRB2
positive regulation of protein secretion (GO:0050714)	4.39	2	TNF, IL13
cellular response to cytokine stimulus (GO:0071345)	4.33	2	IL13, CCL11
receptor-mediated endocytosis (GO:0006898)	4.31	2	ADRB2, SCGB3A2
response to nicotine (GO:0035094)	5.78	2	TNF, IL13
regulation of transferase activity (GO:0051338)	2.88	2	TNF, ADRB2
negative regulation of leukocyte activation (GO:0002695)	4.79	2	SCGB1A1, HLA-G
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	2	TNF, ADRB2
positive regulation of leukocyte activation (GO:0002696)	4.0	2	IL13, HLA-G
posttranscriptional regulation of gene expression (GO:0010608)	3.64	2	TNF, SCGB1A1
positive regulation of immune effector process (GO:0002699)	4.69	2	TNF, IL13
negative regulation of immune effector process (GO:0002698)	5.1	2	TNF, SPINK5
negative regulation of response to external stimulus (GO:0032102)	4.18	2	ADRB2, SPINK5
phosphorylation (GO:0016310)	2.63	2	TNF, CCL11
establishment of localization in cell (GO:0051649)	2.47	2	TNF, ADRB2
regulation of cellular protein localization (GO:1903827)	3.43	2	TNF, HNMT
negative regulation of signaling (GO:0023057)	2.65	2	TNF, ADRB2
signaling (GO:0023052)	3.25	2	ADRB2, IL13
regulation of secretion by cell (GO:1903530)	3.28	2	TNF, IL13
regulation of protein targeting (GO:1903533)	4.0	2	TNF, HNMT
positive regulation of secretion by cell (GO:1903532)	3.93	2	TNF, IL13
negative regulation of blood vessel morphogenesis (GO:2000181)	5.38	2	SPINK5, ADRB2
anatomical structure morphogenesis (GO:0009653)	2.53	2	TNF, CCL11
regulation of protein complex assembly (GO:0043254)	3.83	2	TNF, CCL11
positive regulation of cellular protein localization (GO:1903829)	3.85	2	TNF, HNMT
negative regulation of protein metabolic process (GO:0051248)	2.82	2	TNF, SPINK5
regulation of blood vessel size (GO:0050880)	4.8	2	ADRB2, ALOX5
regulation of system process (GO:0044057)	3.53	2	ADRB2, ALOX5
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	3.12	2	TNF, SCGB1A1
positive regulation of kinase activity (GO:0033674)	3.54	2	TNF, ADRB2
cell adhesion (GO:0007155)	2.82	2	TNF, CCL11
negative regulation of leukocyte cell-cell adhesion (GO:1903038)	5.19	2	SCGB1A1, HLA-G
positive regulation of leukocyte cell-cell adhesion (GO:1903039)	4.35	2	TNF, HLA-G
positive regulation of lipid metabolic process (GO:0045834)	4.88	2	TNF, ADRB2
biological adhesion (GO:0022610)	2.81	2	TNF, CCL11
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	2	TNF, ADRB2
negative regulation of cell proliferation (GO:0008285)	3.26	2	SCGB1A1, HLA-G
neurological system process (GO:0050877)	2.64	2	ADRB2, ALOX5
positive regulation of protein complex assembly (GO:0031334)	4.44	2	TNF, CCL11
regulation of T cell differentiation (GO:0045580)	5.07	2	SPINK5, HLA-G
regulation of vesicle-mediated transport (GO:0060627)	3.63	2	TNF, IL13
positive regulation of ion transport (GO:0043270)	4.36	2	ADRB2, IL13
negative regulation of transcription, DNA-templated (GO:0045892)	2.75	2	SCGB1A1, TNF
response to acid chemical (GO:0001101)	4.05	2	TNF, SCGB1A1
cytoskeleton organization (GO:0007010)	3.22	2	TNF, CCL11
cellular lipid metabolic process (GO:0044255)	2.92	2	PLA2G7, ALOX5
negative regulation of cellular protein metabolic process (GO:0032269)	2.88	2	TNF, SPINK5
organic acid metabolic process (GO:0006082)	3.01	2	HNMT, ALOX5
positive regulation of lymphocyte activation (GO:0051251)	4.07	2	IL13, HLA-G
negative regulation of lymphocyte activation (GO:0051250)	4.95	2	SCGB1A1, HLA-G
negative regulation of RNA metabolic process (GO:0051253)	2.66	2	TNF, SCGB1A1
positive regulation of RNA metabolic process (GO:0051254)	2.51	2	TNF, ADRB2
negative regulation of lymphocyte proliferation (GO:0050672)	5.59	2	SCGB1A1, HLA-G
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	2	TNF, ADRB2
nitrogen compound metabolic process (GO:0006807)	1.13	2	PHF11, HNMT
regulation of humoral immune response (GO:0002920)	5.82	2	TNF, SPINK5
regulation of lymphocyte differentiation (GO:0045619)	4.84	2	SPINK5, HLA-G
positive regulation of ERK1 and ERK2 cascade (GO:0070374)	4.56	2	TNF, CCL11
regulation of ERK1 and ERK2 cascade (GO:0070372)	4.23	2	TNF, CCL11
negative regulation of angiogenesis (GO:0016525)	5.42	2	SPINK5, ADRB2
regulation of cellular response to stress (GO:0080135)	3.4	2	TNF, ADRB2
negative regulation of growth (GO:0045926)	4.24	2	TNF, ADRB2
negative regulation of T cell activation (GO:0050868)	5.26	2	SCGB1A1, HLA-G
regulation of cellular catabolic process (GO:0031329)	3.83	2	TNF, ADRB2
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	2	TNF, ADRB2
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	2	TNF, SCGB1A1
positive regulation of cell activation (GO:0050867)	3.97	2	IL13, HLA-G
carboxylic acid metabolic process (GO:0019752)	3.12	2	HNMT, ALOX5
homeostatic process (GO:0042592)	2.61	2	ADRB2, CCL11
leukocyte migration (GO:0050900)	4.19	2	TNF, CCL11
regulation of mitochondrion organization (GO:0010821)	4.34	2	ADRB2, HNMT
positive regulation of mitochondrion organization (GO:0010822)	4.61	2	ADRB2, HNMT
positive regulation of cell death (GO:0010942)	3.32	2	TNF, ADRB2
regulation of ion transport (GO:0043269)	3.4	2	ADRB2, IL13
positive regulation of cell-cell adhesion (GO:0022409)	4.23	2	TNF, HLA-G
positive regulation of immune response (GO:0050778)	3.4	2	TNF, IL13
protein complex subunit organization (GO:0071822)	2.6	2	TNF, ADRB2
response to interleukin-1 (GO:0070555)	5.07	2	CCL11, HNMT
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	2	SCGB1A1, TNF
positive regulation of apoptotic process (GO:0043065)	3.38	2	TNF, ADRB2
negative regulation of apoptotic process (GO:0043066)	3.04	2	TNF, IL13
negative regulation of leukocyte proliferation (GO:0070664)	5.52	2	SCGB1A1, HLA-G
extracellular structure organization (GO:0043062)	4.0	2	TNF, SPINK5
negative regulation of programmed cell death (GO:0043069)	3.02	2	TNF, IL13
positive regulation of programmed cell death (GO:0043068)	3.38	2	TNF, ADRB2
protein phosphorylation (GO:0006468)	2.89	2	TNF, CCL11
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	2	TNF, ADRB2
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	2	TNF, SCGB1A1
response to oxygen levels (GO:0070482)	4.02	2	ADRB2, ALOX5
regulation of lipid metabolic process (GO:0019216)	4.08	2	TNF, ADRB2
regulation of endopeptidase activity (GO:0052548)	3.8	2	TNF, SPINK5
protein complex assembly (GO:0006461)	2.78	2	TNF, ADRB2
organic substance catabolic process (GO:1901575)	2.45	2	PLA2G7, HNMT
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	2	SCGB1A1, TNF
reproductive process (GO:0022414)	2.55	2	SCGB1A1, ADRB2
multi-organism cellular process (GO:0044764)	3.14	2	TNF, CCL11
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	2	TNF, SCGB1A1
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	2	TNF, ADRB2
cell-cell signaling (GO:0007267)	3.35	2	ADRB2, IL13
regulation of protein secretion (GO:0050708)	3.77	2	TNF, IL13
negative regulation of nucleic acid-templated transcription (GO:1903507)	2.71	2	SCGB1A1, TNF
catabolic process (GO:0009056)	2.38	2	PLA2G7, HNMT
cellular localization (GO:0051641)	2.32	2	TNF, ADRB2
locomotion (GO:0040011)	2.91	2	TNF, CCL11
regulation of immunoglobulin production (GO:0002637)	5.86	2	TNF, IL13
carbohydrate metabolic process (GO:0005975)	3.26	2	TNF, MUC7
organelle organization (GO:0006996)	2.02	2	TNF, CCL11
response to osmotic stress (GO:0006970)	5.57	2	TNF, HNMT
regulation of calcium ion transport (GO:0051924)	4.38	2	ADRB2, IL13
regulation of lipid catabolic process (GO:0050994)	5.8	2	TNF, ADRB2
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	2	SCGB1A1, TNF
positive regulation of leukocyte differentiation (GO:1902107)	4.85	2	TNF, HLA-G
regulation of cellular component biogenesis (GO:0044087)	3.08	2	TNF, CCL11
phosphate-containing compound metabolic process (GO:0006796)	2.16	2	TNF, CCL11
regulation of peptidase activity (GO:0052547)	3.75	2	TNF, SPINK5
phosphorus metabolic process (GO:0006793)	2.15	2	TNF, CCL11
symbiosis, encompassing mutualism through parasitism (GO:0044403)	3.15	2	TNF, CCL11
positive regulation of cellular component biogenesis (GO:0044089)	3.71	2	TNF, CCL11
cellular biosynthetic process (GO:0044249)	1.37	2	PHF11, ALOX5
regulation of growth (GO:0040008)	3.26	2	TNF, ADRB2
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	2	TNF, ADRB2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
regulation of lymphocyte activation (GO:0051249)	-	3.73	0.005	SCGB1A1, ADRB2, CCL11, TNF, SPINK5, IL13, HLA-G
response to biotic stimulus (GO:0009607)	-	3.09	0.042	TNF, SCGB1A1, IL13, CCL11, HNMT
response to cytokine (GO:0034097)	-	3.84	0.001	SCGB1A1, CCL11, TNF, HNMT, IL13, HLA-G
regulation of smooth muscle cell proliferation (GO:0048660)	-	5.1	0.026	TNF, IL13, ADRB2, ALOX5
positive regulation of smooth muscle cell proliferation (GO:0048661)	-	5.6	0.002	TNF, IL13, ADRB2, ALOX5
regulation of cell activation (GO:0050865)	-	3.53	0.023	SCGB1A1, ADRB2, CCL11, TNF, SPINK5, IL13, HLA-G
chronic inflammatory response (GO:0002544)	-	7.16	0.03	TNF, CCL11
regulation of T cell activation (GO:0050863)	-	4.05	0.014	SCGB1A1, CCL11, TNF, SPINK5, IL13, HLA-G
regulation of leukocyte activation (GO:0002694)	-	3.6	0.013	SCGB1A1, ADRB2, CCL11, TNF, SPINK5, IL13, HLA-G
negative regulation of interleukin-5 production (GO:0032714)	NEW	7.78	0.042	SCGB1A1, TNF
negative regulation of interleukin-4 production (GO:0032713)	NEW	7.94	0.042	TNF, SCGB1A1
response to alkaloid (GO:0043279)	-	4.83	0.045	TNF, IL13, HNMT
production of molecular mediator involved in inflammatory response (GO:0002532)	NEW	7.65	0.0	TNF, IL13, ALOX5
tissue homeostasis (GO:0001894)	NEW	4.78	0.013	SCGB1A1, TNF, IL13, ADRB2, MUC7
regulation of defense response (GO:0031347)	-	3.11	0.028	SCGB1A1, ADRB2, SCGB3A2, TNF, ALOX5, PLA2G7, HLA-G

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	13	SCGB1A1, ADRB2, CCL11, ALOX5, TNF, SPINK5, MUC7, HNMT, PHF11, IL13, SCGB3A2, PLA2G7, HLA-G
intracellular part (GO:0044424)	0.28	12	SCGB1A1, ADRB2, MUC7, TNF, SPINK5, ALOX5, HNMT, PHF11, IL13, SCGB3A2, PLA2G7, HLA-G
cytoplasmic part (GO:0044444)	0.82	9	SCGB1A1, ADRB2, SCGB3A2, TNF, SPINK5, ALOX5, HNMT, MUC7, HLA-G
extracellular region part (GO:0044421)	1.57	9	SCGB1A1, CCL11, MUC7, TNF, SPINK5, ALOX5, HNMT, PLA2G7, IL13
extracellular region (GO:0005576)	2.18	8	SCGB1A1, CCL11, SCGB3A2, TNF, SPINK5, MUC7, PLA2G7, IL13
membrane-bounded organelle (GO:0043227)	0.47	8	SCGB1A1, ADRB2, MUC7, TNF, SPINK5, ALOX5, HNMT, PHF11
organelle (GO:0043226)	0.4	8	SCGB1A1, ADRB2, MUC7, TNF, SPINK5, ALOX5, HNMT, PHF11
intracellular organelle part (GO:0044446)	0.81	7	SCGB1A1, SCGB3A2, SPINK5, ALOX5, HNMT, MUC7, HLA-G
cytoplasm (GO:0005737)	1.01	7	SCGB1A1, ADRB2, ALOX5, SPINK5, HNMT, IL13, PLA2G7
organelle part (GO:0044422)	0.79	7	SCGB1A1, SCGB3A2, SPINK5, ALOX5, HNMT, MUC7, HLA-G
intracellular organelle (GO:0043229)	0.51	6	SCGB1A1, ADRB2, ALOX5, TNF, SPINK5, PHF11
intracellular membrane-bounded organelle (GO:0043231)	0.6	6	SCGB1A1, ADRB2, ALOX5, TNF, SPINK5, PHF11
extracellular space (GO:0005615)	2.63	6	SCGB1A1, CCL11, ALOX5, TNF, IL13, PLA2G7
membrane part (GO:0044425)	0.95	5	TNF, SPINK5, ADRB2, IL13, HLA-G
membrane (GO:0016020)	0.68	5	TNF, SPINK5, ADRB2, ALOX5, HLA-G
extracellular organelle (GO:0043230)	1.89	4	SCGB1A1, SPINK5, HNMT, MUC7
vesicle (GO:0031982)	1.64	4	SCGB1A1, SPINK5, HNMT, MUC7
membrane-bounded vesicle (GO:0031988)	1.71	4	SCGB1A1, SPINK5, HNMT, MUC7
plasma membrane (GO:0005886)	1.39	4	TNF, ADRB2, ALOX5, HLA-G
extracellular vesicle (GO:1903561)	1.89	4	SCGB1A1, SPINK5, HNMT, MUC7
plasma membrane part (GO:0044459)	1.95	4	TNF, IL13, ADRB2, HLA-G
extracellular exosome (GO:0070062)	1.89	4	SCGB1A1, SPINK5, HNMT, MUC7
macromolecular complex (GO:0032991)	1.35	3	PLA2G7, ADRB2, HLA-G
organelle lumen (GO:0043233)	3.05	3	SCGB3A2, MUC7, ALOX5
integral component of membrane (GO:0016021)	1.14	3	TNF, ADRB2, HLA-G
nucleus (GO:0005634)	1.07	3	PHF11, ADRB2, ALOX5
membrane-enclosed lumen (GO:0031974)	3.05	3	SCGB3A2, MUC7, ALOX5
intracellular (GO:0005622)	2.37	3	TNF, SCGB1A1, CCL11
neuron part (GO:0097458)	2.64	3	ADRB2, HNMT, ALOX5
intracellular organelle lumen (GO:0070013)	3.05	3	SCGB3A2, MUC7, ALOX5
nuclear part (GO:0044428)	1.55	3	SCGB1A1, HNMT, ALOX5
neuron projection (GO:0043005)	3.12	3	ADRB2, HNMT, ALOX5
cell projection (GO:0042995)	2.47	3	ADRB2, HNMT, ALOX5
cytosol (GO:0005829)	1.68	3	SPINK5, HNMT, ALOX5
intrinsic component of membrane (GO:0031224)	1.13	3	TNF, ADRB2, HLA-G
external side of plasma membrane (GO:0009897)	4.46	2	TNF, IL13
endoplasmic reticulum (GO:0005783)	2.56	2	SCGB1A1, SPINK5
dendrite (GO:0030425)	3.92	2	ADRB2, ALOX5
envelope (GO:0031975)	4.62	2	SCGB1A1, ALOX5
side of membrane (GO:0098552)	4.22	2	TNF, IL13
intrinsic component of plasma membrane (GO:0031226)	2.53	2	TNF, ADRB2
organelle membrane (GO:0031090)	1.97	2	HLA-G, ALOX5
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	2	SCGB1A1, SPINK5
cytoplasmic vesicle (GO:0031410)	2.87	2	SCGB1A1, SPINK5
nuclear envelope (GO:0005635)	4.72	2	SCGB1A1, ALOX5
cytoplasmic vesicle part (GO:0044433)	3.41	2	SCGB3A2, HLA-G
endoplasmic reticulum part (GO:0044432)	2.73	2	SPINK5, HLA-G
Golgi apparatus part (GO:0044431)	3.0	2	HLA-G, MUC7
sarcolemma (GO:0042383)	5.2	2	ADRB2, ALOX5
secretory vesicle (GO:0099503)	4.0	2	SCGB1A1, SPINK5
secretory granule (GO:0030141)	4.34	2	SCGB1A1, SPINK5
membrane region (GO:0098589)	3.95	2	TNF, ADRB2
organelle envelope (GO:0031967)	4.63	2	SCGB1A1, ALOX5
intracellular vesicle (GO:0097708)	2.86	2	SCGB1A1, SPINK5
integral component of plasma membrane (GO:0005887)	2.57	2	TNF, ADRB2
protein complex (GO:0043234)	1.51	2	ADRB2, HLA-G
membrane raft (GO:0045121)	4.18	2	TNF, ADRB2
vacuole (GO:0005773)	2.92	2	TNF, ADRB2
membrane microdomain (GO:0098857)	4.17	2	TNF, ADRB2
endosome (GO:0005768)	3.25	2	TNF, ADRB2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
cytoplasmic membrane-bounded vesicle (GO:0016023)	-	3.12	0.023	SCGB1A1, ADRB2, MUC7, TNF, SPINK5, ALOX5, IL13
membrane region (GO:0098589)	-	3.95	0.011	SCGB1A1, ADRB2, CCL11, ALOX5, TNF, SPINK5, MUC7, IL13, HLA-G
extracellular region (GO:0005576)	-	2.18	0.0	SCGB1A1, ADRB2, CCL11, ALOX5, TNF, SPINK5, MUC7, IL13, SCGB3A2, PLA2G7, HLA-G
cell projection membrane (GO:0031253)	NEW	4.11	0.032	TNF, SCGB1A1, ADRB2, ALOX5, HLA-G
extracellular region part (GO:0044421)	-	1.57	0.011	SCGB1A1, CCL11, MUC7, TNF, SPINK5, ALOX5, HNMT, PLA2G7, IL13