Disease table of LEUKEMIA, ACUTE LYMPHOBLASTIC OMIM ID: 613065

Gene-disease associations table

Gene	Associated with LEUKEMIA, ACUTE LYMPHOBLASTIC in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
TAL1	OMIM	HGNC link	1p33	1	613065
TCF3	OMIM	HGNC link	19p13.3	1	613065
TAL2	OMIM	HGNC link	9q31.2	1	613065
BAX	OMIM	HGNC link	19q13.33	2	114500, 613065
PAX5	HUMSAVAR	HGNC link	9p13.2	2	615545, 613065
NBN	OMIM	HGNC link	8q21.3	4	609135, 613065, 114480, 251260
NUP214	OMIM	HGNC link	9q34.13	2	601626, 613065
FLT3	ClinVar, OMIM	HGNC link	13q12.2	2	601626, 613065
BCR	OMIM	HGNC link	22q11.23	2	608232, 613065

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
9q3	2	NUP214, TAL2

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
9q	2	NUP214, TAL2

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
19	2	TCF3, BAX
9	3	PAX5, NUP214, TAL2

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
TAL1	YES	8	CD34, MYB, EPOR, TERT, ERG, ANGPT2, NFKB1, KRT7	0
TCF3	YES	14	AICDA, CDKN1A, CDK6, BBC3, CD4, INSM1, RAG1, CDH1, INS, POU5F1, EXO1, IL5RA, MYC, CR2	0
PAX5	YES	20	XBP1, BAX, FCER2, LEF1, BLK, BCL2, MET, CCND1, RAG2, CDKN1A, TP53, PRDM1, RB1, CD79A, PRKCE, TIMP1, FHL2, MMP1, MYCN, CD19	1	BAX
PML	NO	18	CDKN1A, IFNB1, FLT3, TNFSF10, EP300, UBA7, PML, BAX, TP53, HCK, CASP3, HBD, CCNT1, NR4A1, EGFR, EAF2, HIPK2, CCND1	2	BAX, FLT3
TP53	NO	159	ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING1	2	BAX, PAX5

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
TAL1	YES	2	GATA1, ETS2	0
TCF3	YES	3	LMX1B, LDB1, LEF1	0
BAX	YES	25	ATM, ING4, ERCC2, TP53, MYCN, PAX5, SP1, GFI1, PML, ABL1, AATF, MLLT10, ETS1, WWTR1, ELL, MLLT3, PER1, RELA, NFKB1, STAT1, TP63, NR3C1, ING1, TP73, HIF1A	1	PAX5
PAX5	YES	1	TP53	0
NBN	YES	2	MYC, SIRT1	0
FLT3	YES	2	PML, STAT3	0
CDKN1A	NO	118	ABL1, TFAP4, TP53, MYF5, TCF3, HDAC9, PAX5, ZBTB2, LCOR, E2F3, ZBTB5, HSF1, ELL, TSC22D3, NCOA1, TAF1, RELA, MYOD1, STAT1, PTTG1, KLF16, ESR1, JUNB, MYCN, KAT2B, AR, BCL6, KLF10, EZH2, ARID1A, JUND, SP1, CEBPB, ZFHX3, ZNF300, EGR1, KLF4, AATF, HDAC7, HBP1, SMARCA4, ESR2, FOXP3, RARA, NELFCD, ING4, HDAC4, TBX2, IRF1, HDAC2, ETV6, SIRT2, MYOG, KLF6, TP73, SOX6, ATM, ERCC2, SMAD4, ETS2, NUPR1, PTMA, MLLT10, SMAD3, ETS1, CBX8, BRCA1, HIPK2, SIRT1, WT1, ZNF76, HDAC1, SMAD2, MLLT3, TFAP2A, EP300, FHL2, TP63, IRF9, EHMT2, TFAP2C, NFIX, RUNX3, RB1, HNF4A, NFIB, TAF5, SOX9, TBP, EAPP, ZBTB17, TAF4, REL, RELB, PML, SMAD7, NPM1, POU5F1, E2F1, TBX3, FOXG1, MYF6, NFIA, ATF2, PARP1, NFKB1, STAT3, GFI1, NR3C1, CREBBP, MTA1, JUN, KLF2, CDX2, SP3, MYC, PPARG, ING1	2	TCF3, PAX5

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
TAL1	TCF3	Yes	19	KDM1A, KAT2B, TRIM33, RCOR1, CBFA2T3, TCF4, EP300, TCF12, SSBP1, HDAC2, RB1, TCF3, TRRAP, TAL1, SKP2, PARP1, LDB1, LYL1, RUNX1
TAL1	TAL2	No	5	TCF12, LMO2, CBFA2T2, LMO1, TCF4
TAL1	BAX	No	1	XRCC6
TAL1	PAX5	No	3	RUNX1, RB1, EP300
TAL1	NBN	No	2	EP300, SKP2
TAL1	BCR	No	3	UBC, RB1, STUB1
TCF3	TAL2	No	3	RUNX1T1, TCF12, TCF4
TCF3	BAX	No	4	SLC25A4, YY1, PCBP1, SERPINH1
TCF3	PAX5	No	5	ID3, EP300, DAXX, RUNX1, RB1
TCF3	NBN	No	2	EP300, SKP2
TCF3	NUP214	No	3	UBE2I, XPO1, SOX2
TCF3	BCR	No	2	RB1, XPO1
BAX	NBN	No	3	HSPA4, XRCC5, LIG3
BAX	BCR	No	3	HSPD1, HSPA4, TP53
PAX5	NBN	No	1	EP300
PAX5	BCR	No	1	RB1
NBN	NUP214	No	1	IPO5
NBN	BCR	No	1	HSPA4
NUP214	BCR	No	2	NTRK1, XPO1
FLT3	BCR	No	3	GRB2, CBL, HSP90AA1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
TAL1	TCF3	Yes	binding	10	GATA3, EP300, TCF12, HDAC2, LDB2, SIN3A, UBC, LMO2, RUNX1, LDB1
TAL1	TAL2	No	-	4	LMO2, LMO1, TCF3, TCF4
TAL1	BAX	No	-	4	UBC, RB1, EP300, AKT1
TAL1	PAX5	No	-	5	EP300, RB1, RUNX1, TCF3, ETS1
TAL1	NUP214	No	-	1	HDAC1
TAL1	FLT3	No	-	2	UBC, AKT1
TAL1	BCR	No	-	3	UBC, KIT, AKT1
TCF3	TAL2	Yes	binding	1	LMO2
TCF3	BAX	No	-	4	UBC, IL6, EP300, CREBBP
TCF3	PAX5	Yes	activation, binding	4	KAT2B, RUNX1, EBF1, EP300
TCF3	NUP214	No	-	1	UBE2I
TCF3	FLT3	No	-	3	UBC, NCOR1, CTNNB1
TCF3	BCR	No	-	3	UBC, PAX2, PAX5
TAL2	PAX5	No	-	1	TCF3
BAX	PAX5	No	-	4	MYC, EP300, RB1, TP53
BAX	NUP214	No	-	1	MAPK8
BAX	FLT3	No	-	4	UBC, STAT3, SIRT1, AKT1
BAX	BCR	No	-	5	BCL2L11, UBC, BCL2L1, PTEN, AKT1
PAX5	NUP214	No	-	0
PAX5	FLT3	No	-	4	STAT5B, MYB, STAT5A, SPI1
PAX5	BCR	Yes	binding, activation, expression	2	STAT5B, STAT5A
NUP214	BCR	No	-	0
FLT3	BCR	No	-	9	PIK3CG, CBL, STAT5A, PIK3CA, STAT5B, HSP90AA1, AKT1, UBC, GRB2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
TAL1	TCF3	Yes	Rb-tal-1-E2A-Lmo2-Ldb1 complex	3	LMO2, RB1, LDB1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
TAL1	TCF3	Yes	2	TCF3, TAL1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Pathways in cancer	hsa05200	3.98	3	BAX, FLT3, BCR
Transcriptional misregulation in cancer	hsa05202	5.21	3	FLT3, PAX5, TCF3
HTLV-I infection	hsa05166	4.59	2	BAX, TCF3

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Cancers: Overview	NEW	2.72	0.023	NBN, BAX, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
Cancers: Specific types	NEW	4.1	0.006	NBN, BAX, TCF3, PAX5, FLT3, BCR
Acute myeloid leukemia (hsa05221)	NEW	6.74	0.0	BCR, FLT3, TCF3, PAX5
Transcriptional misregulation in cancer (hsa05202)	-	5.21	0.006	TAL2, BAX, FLT3, PAX5, TCF3

REACTOME pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Cell Cycle	R-HSA-1640170	3.89	2	NBN, NUP214
Cellular responses to stress	R-HSA-2262752	4.56	2	NBN, NUP214
Disease	R-HSA-1643685	3.33	2	BCR, NUP214

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	9	NBN, BAX, NUP214, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
protein binding (GO:0005515)	0.46	9	NBN, BAX, NUP214, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
organic cyclic compound binding (GO:0097159)	1.05	7	NBN, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
heterocyclic compound binding (GO:1901363)	1.06	7	NBN, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
protein dimerization activity (GO:0046983)	2.72	5	BAX, FLT3, TAL1, TCF3, TAL2
nucleic acid binding (GO:0003676)	1.44	5	NBN, TAL2, TAL1, PAX5, TCF3
DNA binding (GO:0003677)	1.92	5	NBN, TAL2, TAL1, PAX5, TCF3
transcription regulatory region DNA binding (GO:0044212)	3.03	4	TAL2, TAL1, PAX5, TCF3
sequence-specific double-stranded DNA binding (GO:1990837)	3.2	4	TAL2, TAL1, PAX5, TCF3
sequence-specific DNA binding (GO:0043565)	2.79	4	TAL2, TAL1, PAX5, TCF3
transcription factor activity, sequence-specific DNA binding (GO:0003700)	2.65	4	TAL2, TAL1, PAX5, TCF3
regulatory region nucleic acid binding (GO:0001067)	3.03	4	TAL2, TAL1, PAX5, TCF3
RNA polymerase II regulatory region DNA binding (GO:0001012)	3.36	4	TAL2, TAL1, PAX5, TCF3
transcription regulatory region sequence-specific DNA binding (GO:0000976)	3.24	4	TAL2, TAL1, PAX5, TCF3
nucleic acid binding transcription factor activity (GO:0001071)	2.65	4	TAL2, TAL1, PAX5, TCF3
regulatory region DNA binding (GO:0000975)	3.03	4	TAL2, TAL1, PAX5, TCF3
double-stranded DNA binding (GO:0003690)	3.09	4	TAL2, TAL1, PAX5, TCF3
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981)	3.29	4	TAL2, TAL1, PAX5, TCF3
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)	3.37	4	TAL2, TAL1, PAX5, TCF3
transcription factor binding (GO:0008134)	3.46	3	NBN, TCF3, TAL1
enzyme binding (GO:0019899)	2.27	3	BCR, TAL1, TCF3
catalytic activity (GO:0003824)	1.05	3	NBN, BCR, FLT3
macromolecular complex binding (GO:0044877)	2.61	3	BAX, FLT3, TAL1
protein heterodimerization activity (GO:0046982)	3.64	3	BAX, TCF3, TAL1
identical protein binding (GO:0042802)	2.63	3	BAX, FLT3, TCF3
protein homodimerization activity (GO:0042803)	3.16	3	BAX, FLT3, TCF3
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	2	BCR, FLT3
core promoter proximal region DNA binding (GO:0001159)	3.82	2	TCF3, PAX5
protein kinase activity (GO:0004672)	3.27	2	BCR, FLT3
purine nucleoside binding (GO:0001883)	2.22	2	BCR, FLT3
E-box binding (GO:0070888)	6.21	2	TCF3, TAL1
nucleoside phosphate binding (GO:1901265)	1.96	2	BCR, FLT3
nucleoside binding (GO:0001882)	2.21	2	BCR, FLT3
nucleotide binding (GO:0000166)	1.96	2	BCR, FLT3
transferase activity (GO:0016740)	1.95	2	BCR, FLT3
protein tyrosine kinase activity (GO:0004713)	4.54	2	BCR, FLT3
ribonucleoside binding (GO:0032549)	2.22	2	BCR, FLT3
protein complex binding (GO:0032403)	3.09	2	BAX, FLT3
purine nucleotide binding (GO:0017076)	2.19	2	BCR, FLT3
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0000982)	3.94	2	TCF3, PAX5
ATP binding (GO:0005524)	2.43	2	BCR, FLT3
transporter activity (GO:0005215)	2.57	2	BAX, NUP214
kinase activity (GO:0016301)	2.93	2	BCR, FLT3
small molecule binding (GO:0036094)	1.89	2	BCR, FLT3
core promoter proximal region sequence-specific DNA binding (GO:0000987)	3.83	2	TCF3, PAX5
enhancer binding (GO:0035326)	5.21	2	TCF3, TAL1
adenyl nucleotide binding (GO:0030554)	2.4	2	BCR, FLT3
carbohydrate derivative binding (GO:0097367)	2.03	2	BCR, FLT3
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	2	BCR, FLT3
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	2	BCR, FLT3
adenyl ribonucleotide binding (GO:0032559)	2.41	2	BCR, FLT3
purine ribonucleotide binding (GO:0032555)	2.2	2	BCR, FLT3
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978)	3.88	2	TCF3, PAX5
purine ribonucleoside binding (GO:0032550)	2.22	2	BCR, FLT3
ribonucleotide binding (GO:0032553)	2.19	2	BCR, FLT3

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
sequence-specific DNA binding (GO:0043565)	-	2.79	0.024	NBN, TCF3, TAL1, FLT3, TAL2, PAX5
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)	-	3.37	0.028	TAL1, PAX5, TCF3
sequence-specific DNA binding transcription factor activity (GO:0003700)	-	2.65	0.013	NBN, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
transcription factor binding (GO:0008134)	-	3.46	0.043	NBN, TAL1, PAX5, NUP214, TCF3
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978)	-	3.88	0.018	FLT3, TAL1, PAX5, TCF3
RNA polymerase II regulatory region DNA binding (GO:0001012)	-	3.36	0.029	TAL1, PAX5, TCF3
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001228)	NEW	3.98	0.001	NBN, FLT3, TAL1, PAX5, TCF3
enzyme binding (GO:0019899)	-	2.27	0.008	NBN, BAX, NUP214, TCF3, BCR, TAL1, FLT3, PAX5
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001077)	NEW	4.31	0.012	FLT3, TAL1, PAX5, TCF3
transcription regulatory region sequence-specific DNA binding (GO:0000976)	-	3.24	0.048	TAL1, PAX5, TCF3
nucleic acid binding transcription factor activity (GO:0001071)	-	2.65	0.013	NBN, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
core promoter proximal region sequence-specific DNA binding (GO:0000987)	-	3.83	0.02	FLT3, TAL1, PAX5, TCF3
E-box binding (GO:0070888)	-	6.21	0.01	TCF3, TAL1
protein dimerization activity (GO:0046983)	-	2.72	0.008	BAX, FLT3, TAL1, TCF3, TAL2
protein heterodimerization activity (GO:0046982)	-	3.64	0.005	BAX, TCF3, TAL1, FLT3, TAL2, PAX5
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity (GO:0000982)	-	3.94	0.002	NBN, FLT3, TAL1, PAX5, TCF3
core promoter proximal region DNA binding (GO:0001159)	-	3.82	0.02	FLT3, TAL1, PAX5, TCF3
sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0000981)	-	3.29	0.026	NBN, FLT3, TAL1, PAX5, TCF3

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
primary metabolic process (GO:0044238)	0.69	9	NBN, BAX, NUP214, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
cellular process (GO:0009987)	0.26	9	NBN, BAX, NUP214, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
cellular metabolic process (GO:0044237)	0.69	9	NBN, BAX, NUP214, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
regulation of cellular process (GO:0050794)	0.5	9	NBN, BAX, NUP214, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
organic substance metabolic process (GO:0071704)	0.63	9	NBN, BAX, NUP214, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
biological regulation (GO:0065007)	0.39	9	NBN, BAX, NUP214, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
metabolic process (GO:0008152)	0.58	9	NBN, BAX, NUP214, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
regulation of biological process (GO:0050789)	0.45	9	NBN, BAX, NUP214, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
single-organism process (GO:0044699)	0.48	9	NBN, BAX, NUP214, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
developmental process (GO:0032502)	1.36	8	NBN, BAX, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
cellular macromolecule metabolic process (GO:0044260)	0.93	8	NBN, NUP214, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
regulation of metabolic process (GO:0019222)	1.02	8	NBN, BAX, NUP214, TCF3, TAL1, FLT3, TAL2, PAX5
regulation of macromolecule metabolic process (GO:0060255)	1.08	8	NBN, BAX, NUP214, TCF3, TAL1, FLT3, TAL2, PAX5
anatomical structure development (GO:0048856)	1.58	8	NBN, BAX, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
macromolecule metabolic process (GO:0043170)	0.83	8	NBN, NUP214, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
single-organism cellular process (GO:0044763)	0.65	8	NBN, BAX, NUP214, TCF3, BCR, TAL1, FLT3, PAX5
regulation of primary metabolic process (GO:0080090)	1.08	7	NBN, BAX, TCF3, TAL1, FLT3, TAL2, PAX5
regulation of cellular metabolic process (GO:0031323)	1.07	7	NBN, BAX, TCF3, TAL1, FLT3, TAL2, PAX5
single-organism developmental process (GO:0044767)	1.49	7	NBN, BAX, TAL1, BCR, FLT3, TAL2, PAX5
nitrogen compound metabolic process (GO:0006807)	1.13	7	NBN, BAX, NUP214, TCF3, TAL1, TAL2, PAX5
positive regulation of biological process (GO:0048518)	1.2	7	NBN, BAX, TCF3, BCR, TAL1, FLT3, PAX5
negative regulation of biological process (GO:0048519)	1.33	7	NBN, BAX, NUP214, TCF3, BCR, TAL1, PAX5
positive regulation of cellular process (GO:0048522)	1.3	7	NBN, BAX, TCF3, BCR, TAL1, FLT3, PAX5
negative regulation of metabolic process (GO:0009892)	1.93	6	NBN, BAX, NUP214, TCF3, TAL1, PAX5
positive regulation of metabolic process (GO:0009893)	1.74	6	NBN, BAX, TCF3, TAL1, FLT3, PAX5
positive regulation of cellular metabolic process (GO:0031325)	1.81	6	NBN, BAX, TCF3, TAL1, FLT3, PAX5
nucleic acid metabolic process (GO:0090304)	1.46	6	NBN, NUP214, TCF3, TAL1, TAL2, PAX5
cellular biosynthetic process (GO:0044249)	1.37	6	NBN, NUP214, TCF3, TAL1, TAL2, PAX5
cellular nitrogen compound metabolic process (GO:0034641)	1.22	6	NBN, NUP214, TCF3, TAL1, TAL2, PAX5
organic cyclic compound biosynthetic process (GO:1901362)	1.66	6	NBN, NUP214, TCF3, TAL1, TAL2, PAX5
organic cyclic compound metabolic process (GO:1901360)	1.26	6	NBN, NUP214, TCF3, TAL1, TAL2, PAX5
nucleobase-containing compound metabolic process (GO:0006139)	1.35	6	NBN, NUP214, TCF3, TAL1, TAL2, PAX5
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	6	NBN, BAX, NUP214, TCF3, TAL1, PAX5
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	6	NBN, BAX, TCF3, TAL1, FLT3, PAX5
regulation of biological quality (GO:0065008)	1.68	6	NBN, BAX, NUP214, TAL1, FLT3, BCR
heterocycle biosynthetic process (GO:0018130)	1.7	6	NBN, NUP214, TCF3, TAL1, TAL2, PAX5
multicellular organismal process (GO:0032501)	1.45	6	NBN, BAX, TAL1, PAX5, TAL2, BCR
organic substance biosynthetic process (GO:1901576)	1.34	6	NBN, NUP214, TCF3, TAL1, TAL2, PAX5
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	6	NBN, BAX, TCF3, TAL1, TAL2, PAX5
cellular aromatic compound metabolic process (GO:0006725)	1.3	6	NBN, NUP214, TCF3, TAL1, TAL2, PAX5
biosynthetic process (GO:0009058)	1.32	6	NBN, NUP214, TCF3, TAL1, TAL2, PAX5
macromolecule biosynthetic process (GO:0009059)	1.61	6	NBN, NUP214, TCF3, TAL1, TAL2, PAX5
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	6	NBN, BAX, TCF3, TAL1, TAL2, PAX5
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	6	NBN, NUP214, TCF3, TAL1, TAL2, PAX5
heterocycle metabolic process (GO:0046483)	1.31	6	NBN, NUP214, TCF3, TAL1, TAL2, PAX5
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	6	NBN, NUP214, TCF3, TAL1, TAL2, PAX5
regulation of cell cycle (GO:0051726)	2.93	6	NBN, BAX, NUP214, TCF3, TAL1, BCR
aromatic compound biosynthetic process (GO:0019438)	1.7	6	NBN, NUP214, TCF3, TAL1, TAL2, PAX5
negative regulation of cellular process (GO:0048523)	1.41	6	NBN, BAX, TAL1, TCF3, PAX5, BCR
RNA metabolic process (GO:0016070)	1.59	5	TAL2, TAL1, NUP214, PAX5, TCF3
negative regulation of cellular metabolic process (GO:0031324)	2.01	5	NBN, BAX, TAL1, PAX5, TCF3
cell differentiation (GO:0030154)	2.14	5	BAX, FLT3, TAL1, PAX5, TCF3
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	5	NBN, BAX, TAL1, PAX5, TCF3
RNA biosynthetic process (GO:0032774)	1.84	5	TAL2, TAL1, NUP214, PAX5, TCF3
single-multicellular organism process (GO:0044707)	1.78	5	NBN, BAX, TAL1, PAX5, TAL2
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	5	NBN, TAL2, TAL1, PAX5, TCF3
response to stimulus (GO:0050896)	1.22	5	NBN, BAX, FLT3, BCR, PAX5
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	5	NBN, BAX, TAL1, PAX5, TCF3
regulation of biosynthetic process (GO:0009889)	1.37	5	NBN, TAL2, TAL1, PAX5, TCF3
regulation of response to stimulus (GO:0048583)	1.54	5	NBN, BAX, FLT3, BCR, NUP214
regulation of cellular component organization (GO:0051128)	2.01	5	NBN, BCR, BAX, TAL1, PAX5
immune system process (GO:0002376)	2.29	5	NBN, BAX, FLT3, PAX5, TCF3
cellular macromolecule biosynthetic process (GO:0034645)	1.66	5	NBN, TAL2, TAL1, PAX5, TCF3
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	5	NBN, TAL2, TAL1, PAX5, TCF3
positive regulation of molecular function (GO:0044093)	2.23	5	NBN, BAX, FLT3, TCF3, BCR
cellular developmental process (GO:0048869)	1.82	5	BAX, FLT3, TAL1, PAX5, TCF3
regulation of gene expression (GO:0010468)	1.37	5	TAL2, TAL1, NUP214, PAX5, TCF3
regulation of molecular function (GO:0065009)	1.78	5	NBN, BAX, FLT3, BCR, TCF3
regulation of cellular biosynthetic process (GO:0031326)	1.38	5	NBN, TAL2, TAL1, PAX5, TCF3
positive regulation of cellular component organization (GO:0051130)	2.68	4	NBN, BAX, TAL1, BCR
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	4	NBN, TAL1, PAX5, TCF3
regulation of organelle organization (GO:0033043)	2.72	4	NBN, BAX, TAL1, PAX5
B cell activation (GO:0042113)	4.84	4	NBN, BAX, FLT3, TCF3
leukocyte activation (GO:0045321)	3.76	4	NBN, BAX, TCF3, FLT3
negative regulation of gene expression (GO:0010629)	2.48	4	TAL1, PAX5, NUP214, TCF3
signal transduction (GO:0007165)	1.28	4	NBN, BAX, FLT3, BCR
regulation of signaling (GO:0023051)	1.72	4	NBN, BAX, FLT3, BCR
regulation of cell communication (GO:0010646)	1.73	4	NBN, BAX, FLT3, BCR
nucleic acid-templated transcription (GO:0097659)	1.91	4	TAL2, TAL1, PAX5, TCF3
regulation of mitotic cell cycle (GO:0007346)	3.71	4	NBN, BAX, TCF3, TAL1
regulation of signal transduction (GO:0009966)	1.84	4	NBN, BAX, FLT3, BCR
regulation of protein metabolic process (GO:0051246)	1.93	4	NBN, BAX, FLT3, PAX5
cellular component organization (GO:0016043)	1.24	4	NBN, BAX, BCR, NUP214
animal organ development (GO:0048513)	2.53	4	BAX, BCR, FLT3, TAL1
regulation of immune system process (GO:0002682)	2.5	4	BAX, BCR, TCF3, TAL1
cellular component organization or biogenesis (GO:0071840)	1.22	4	NBN, BAX, BCR, NUP214
regulation of protein modification process (GO:0031399)	2.32	4	NBN, BAX, FLT3, PAX5
regulation of cell proliferation (GO:0042127)	2.41	4	BAX, FLT3, TAL1, TCF3
positive regulation of catalytic activity (GO:0043085)	2.4	4	NBN, BAX, FLT3, BCR
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	4	NBN, TAL1, PAX5, TCF3
regulation of developmental process (GO:0050793)	2.1	4	BAX, TAL1, BCR, TCF3
regulation of catalytic activity (GO:0050790)	1.97	4	NBN, BAX, FLT3, BCR
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	4	TAL2, TAL1, PAX5, TCF3
cell activation (GO:0001775)	3.47	4	NBN, BAX, TCF3, FLT3
lymphocyte activation (GO:0046649)	3.96	4	NBN, BAX, FLT3, TCF3
regulation of multicellular organismal process (GO:0051239)	1.87	4	BAX, BCR, TAL1, TCF3
regulation of RNA biosynthetic process (GO:2001141)	1.55	4	TAL2, TAL1, PAX5, TCF3
regulation of intracellular signal transduction (GO:1902531)	2.31	4	NBN, BAX, FLT3, BCR
regulation of cellular protein metabolic process (GO:0032268)	1.99	4	NBN, BAX, FLT3, PAX5
regulation of RNA metabolic process (GO:0051252)	1.52	4	TAL2, TAL1, PAX5, TCF3
regulation of transcription, DNA-templated (GO:0006355)	1.56	4	TAL2, TAL1, PAX5, TCF3
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	4	TAL2, TAL1, PAX5, TCF3
transcription, DNA-templated (GO:0006351)	1.91	4	TAL2, TAL1, PAX5, TCF3
regulation of chromosome organization (GO:0033044)	4.11	3	NBN, TAL1, PAX5
regulation of kinase activity (GO:0043549)	3.07	3	NBN, BAX, FLT3
regulation of phosphate metabolic process (GO:0019220)	2.35	3	NBN, BAX, FLT3
negative regulation of biosynthetic process (GO:0009890)	2.47	3	TAL1, PAX5, TCF3
positive regulation of biosynthetic process (GO:0009891)	2.29	3	TAL1, PAX5, TCF3
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	3	TAL1, PAX5, TCF3
regulation of transport (GO:0051049)	2.24	3	BAX, BCR, NUP214
positive regulation of homeostatic process (GO:0032846)	4.38	3	NBN, BAX, TAL1
mitotic cell cycle process (GO:1903047)	3.12	3	NBN, BAX, NUP214
positive regulation of protein metabolic process (GO:0051247)	2.43	3	NBN, BAX, FLT3
homeostatic process (GO:0042592)	2.61	3	NBN, BAX, FLT3
positive regulation of developmental process (GO:0051094)	2.77	3	BAX, TCF3, TAL1
cell cycle process (GO:0022402)	2.75	3	NBN, BAX, NUP214
regulation of mitotic cell cycle phase transition (GO:1901990)	4.23	3	NBN, BAX, TCF3
cell surface receptor signaling pathway (GO:0007166)	2.09	3	BAX, BCR, FLT3
intracellular signal transduction (GO:0035556)	2.39	3	NBN, BAX, BCR
anatomical structure morphogenesis (GO:0009653)	2.53	3	BAX, BCR, PAX5
multicellular organism development (GO:0007275)	2.54	3	NBN, TAL1, PAX5
cellular protein metabolic process (GO:0044267)	1.63	3	BCR, FLT3, NUP214
cellular response to stimulus (GO:0051716)	1.97	3	NBN, BAX, FLT3
regulation of localization (GO:0032879)	1.94	3	BAX, BCR, NUP214
positive regulation of transferase activity (GO:0051347)	3.31	3	NBN, BAX, FLT3
positive regulation of cell cycle (GO:0045787)	3.94	3	BAX, TCF3, TAL1
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	3.12	3	TAL1, PAX5, TCF3
response to lipid (GO:0033993)	3.11	3	BAX, BCR, FLT3
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	3	NBN, BAX, FLT3
positive regulation of kinase activity (GO:0033674)	3.54	3	NBN, BAX, FLT3
regulation of cell cycle process (GO:0010564)	3.5	3	NBN, BAX, TCF3
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	3	TAL1, PAX5, TCF3
peptidyl-amino acid modification (GO:0018193)	2.98	3	BCR, FLT3, NUP214
negative regulation of RNA metabolic process (GO:0051253)	2.66	3	TAL1, PAX5, TCF3
positive regulation of immune system process (GO:0002684)	2.96	3	BAX, TCF3, TAL1
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	3	NBN, BAX, FLT3
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	3	TAL1, PAX5, TCF3
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	3	TAL1, PAX5, TCF3
organelle organization (GO:0006996)	2.02	3	NBN, BAX, BCR
positive regulation of phosphate metabolic process (GO:0045937)	2.78	3	NBN, BAX, FLT3
cell proliferation (GO:0008283)	3.23	3	NBN, BAX, FLT3
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	3	TAL1, PAX5, TCF3
positive regulation of multicellular organismal process (GO:0051240)	2.49	3	BAX, TCF3, TAL1
cellular protein modification process (GO:0006464)	1.79	3	BCR, FLT3, NUP214
negative regulation of nucleic acid-templated transcription (GO:1903507)	2.71	3	TAL1, PAX5, TCF3
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	3	TAL1, PAX5, TCF3
reproductive process (GO:0022414)	2.55	3	NBN, BAX, PAX5
macromolecule modification (GO:0043412)	1.73	3	BCR, FLT3, NUP214
protein modification process (GO:0036211)	1.79	3	BCR, FLT3, NUP214
negative regulation of transcription, DNA-templated (GO:0045892)	2.75	3	TAL1, PAX5, TCF3
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	3	TAL1, PAX5, TCF3
response to chemical (GO:0042221)	1.98	3	BAX, FLT3, BCR
regulation of homeostatic process (GO:0032844)	3.65	3	NBN, BAX, TAL1
response to organic substance (GO:0010033)	2.2	3	BAX, BCR, FLT3
leukocyte differentiation (GO:0002521)	4.13	3	FLT3, TAL1, TCF3
regulation of phosphorylation (GO:0042325)	2.5	3	NBN, BAX, FLT3
regulation of phosphorus metabolic process (GO:0051174)	2.35	3	NBN, BAX, FLT3
positive regulation of phosphorylation (GO:0042327)	2.9	3	NBN, BAX, FLT3
single organism reproductive process (GO:0044702)	2.73	3	NBN, BAX, PAX5
nervous system development (GO:0007399)	3.53	3	BAX, TCF3, PAX5
regulation of cell cycle phase transition (GO:1901987)	4.15	3	NBN, BAX, TCF3
protein metabolic process (GO:0019538)	1.45	3	BCR, FLT3, NUP214
regulation of response to stress (GO:0080134)	2.53	3	BAX, BCR, NUP214
positive regulation of protein modification process (GO:0031401)	2.7	3	NBN, BAX, FLT3
positive regulation of organelle organization (GO:0010638)	3.38	3	NBN, BAX, TAL1
positive regulation of RNA metabolic process (GO:0051254)	2.51	3	TAL1, PAX5, TCF3
regulation of transferase activity (GO:0051338)	2.88	3	NBN, BAX, FLT3
positive regulation of protein phosphorylation (GO:0001934)	2.95	3	NBN, BAX, FLT3
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	3	TAL1, PAX5, TCF3
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	3	TAL1, PAX5, TCF3
positive regulation of gene expression (GO:0010628)	2.35	3	TAL1, PAX5, TCF3
regulation of multicellular organismal development (GO:2000026)	2.31	3	BAX, TCF3, TAL1
system development (GO:0048731)	2.92	3	BAX, TCF3, PAX5
regulation of protein phosphorylation (GO:0001932)	2.57	3	NBN, BAX, FLT3
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	3	TAL1, PAX5, TCF3
developmental growth (GO:0048589)	4.05	2	NBN, TAL2
anatomical structure homeostasis (GO:0060249)	4.25	2	NBN, BAX
negative regulation of response to stimulus (GO:0048585)	2.52	2	BAX, BCR
positive regulation of response to stimulus (GO:0048584)	2.18	2	BAX, FLT3
cell development (GO:0048468)	3.28	2	BAX, TAL1
behavior (GO:0007610)	3.47	2	TAL1, PAX5
membrane organization (GO:0061024)	3.04	2	BAX, NUP214
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	2	BCR, FLT3
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	3.54	2	BCR, FLT3
single-organism metabolic process (GO:0044710)	1.63	2	NBN, BAX
negative regulation of cell cycle (GO:0045786)	3.67	2	NBN, BAX
positive regulation of signal transduction (GO:0009967)	2.5	2	BAX, FLT3
peptidyl-tyrosine modification (GO:0018212)	4.47	2	BCR, FLT3
regulation of programmed cell death (GO:0043067)	2.49	2	BAX, FLT3
interspecies interaction between organisms (GO:0044419)	3.08	2	BAX, NUP214
multi-organism process (GO:0051704)	2.65	2	BAX, NUP214
positive regulation of DNA metabolic process (GO:0051054)	4.49	2	NBN, BAX
regulation of DNA metabolic process (GO:0051052)	3.87	2	NBN, BAX
positive regulation of transport (GO:0051050)	2.9	2	BAX, BCR
response to corticosteroid (GO:0031960)	4.56	2	BAX, FLT3
regulation of protein kinase activity (GO:0045859)	3.15	2	BAX, FLT3
establishment of protein localization (GO:0045184)	2.53	2	BAX, NUP214
spermatogenesis (GO:0007283)	3.7	2	BAX, PAX5
system process (GO:0003008)	2.3	2	NBN, BCR
post-embryonic development (GO:0009791)	5.35	2	BAX, TAL2
homeostasis of number of cells (GO:0048872)	4.98	2	BAX, FLT3
response to organonitrogen compound (GO:0010243)	3.2	2	BAX, FLT3
negative regulation of organelle organization (GO:0010639)	4.07	2	NBN, PAX5
cellular response to stress (GO:0033554)	2.51	2	NBN, BAX
somatic diversification of immunoglobulins (GO:0016445)	6.26	2	NBN, TCF3
somatic cell DNA recombination (GO:0016444)	6.23	2	NBN, TCF3
somatic recombination of immunoglobulin gene segments (GO:0016447)	6.68	2	NBN, TCF3
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	2	BAX, BCR
mononuclear cell proliferation (GO:0032943)	5.32	2	BAX, FLT3
lymphocyte proliferation (GO:0046651)	5.35	2	BAX, FLT3
signal transduction by p53 class mediator (GO:0072331)	4.88	2	NBN, BAX
positive regulation of hydrolase activity (GO:0051345)	2.91	2	BAX, BCR
DNA damage response, signal transduction by p53 class mediator (GO:0030330)	5.3	2	NBN, BAX
somatic diversification of immune receptors (GO:0002200)	5.92	2	NBN, TCF3
organ morphogenesis (GO:0009887)	3.55	2	BAX, PAX5
transport (GO:0006810)	1.51	2	BAX, NUP214
cellular response to organic substance (GO:0071310)	2.78	2	BAX, FLT3
leukocyte homeostasis (GO:0001776)	5.72	2	BAX, FLT3
response to stress (GO:0006950)	1.8	2	NBN, BAX
single-organism membrane organization (GO:0044802)	3.19	2	BAX, NUP214
positive regulation of intracellular signal transduction (GO:1902533)	2.95	2	BAX, FLT3
regulation of protein complex assembly (GO:0043254)	3.83	2	BAX, TAL1
establishment of localization (GO:0051234)	1.48	2	BAX, NUP214
negative regulation of cell cycle phase transition (GO:1901988)	4.74	2	NBN, BAX
regulation of hydrolase activity (GO:0051336)	2.53	2	BAX, BCR
cell fate commitment (GO:0045165)	4.72	2	TCF3, TAL1
brain development (GO:0007420)	4.24	2	BAX, BCR
negative regulation of protein modification process (GO:0031400)	3.4	2	BAX, PAX5
regulation of cellular response to stress (GO:0080135)	3.4	2	BAX, NUP214
regulation of leukocyte activation (GO:0002694)	3.6	2	TCF3, BCR
positive regulation of chromosome organization (GO:2001252)	4.76	2	NBN, TAL1
negative regulation of chromosome organization (GO:2001251)	5.17	2	NBN, PAX5
phosphorylation (GO:0016310)	2.63	2	BCR, FLT3
negative regulation of cellular component organization (GO:0051129)	3.35	2	NBN, PAX5
positive regulation of signaling (GO:0023056)	2.41	2	BAX, FLT3
negative regulation of mitotic cell cycle phase transition (GO:1901991)	4.82	2	NBN, BAX
cellular response to chemical stimulus (GO:0070887)	2.57	2	BAX, FLT3
positive regulation of cell communication (GO:0010647)	2.41	2	BAX, FLT3
protein autophosphorylation (GO:0046777)	4.46	2	BCR, FLT3
response to organic cyclic compound (GO:0014070)	3.07	2	BAX, FLT3
response to endogenous stimulus (GO:0009719)	2.79	2	BAX, FLT3
negative regulation of protein metabolic process (GO:0051248)	2.82	2	BAX, PAX5
neuromuscular process controlling balance (GO:0050885)	5.88	2	NBN, BCR
signal transduction in response to DNA damage (GO:0042770)	5.15	2	NBN, BAX
positive regulation of cell proliferation (GO:0008284)	3.01	2	TCF3, FLT3
DNA recombination (GO:0006310)	4.39	2	NBN, TCF3
multicellular organismal reproductive process (GO:0048609)	3.35	2	BAX, PAX5
somatic diversification of immune receptors via germline recombination within a single locus (GO:0002562)	6.23	2	NBN, TCF3
establishment of protein localization to organelle (GO:0072594)	3.92	2	BAX, NUP214
positive regulation of protein complex assembly (GO:0031334)	4.44	2	BAX, TAL1
cellular response to DNA damage stimulus (GO:0006974)	3.17	2	NBN, BAX
regulation of cell differentiation (GO:0045595)	2.42	2	TCF3, TAL1
male gamete generation (GO:0048232)	3.7	2	BAX, PAX5
negative regulation of cellular protein metabolic process (GO:0032269)	2.88	2	BAX, PAX5
regulation of immune response (GO:0050776)	2.98	2	BAX, BCR
aging (GO:0007568)	4.16	2	BAX, PAX5
regulation of G1/S transition of mitotic cell cycle (GO:2000045)	4.81	2	BAX, TCF3
response to hormone (GO:0009725)	3.33	2	BAX, FLT3
lymphocyte differentiation (GO:0030098)	4.49	2	TCF3, FLT3
hemopoiesis (GO:0030097)	5.07	2	FLT3, TAL1
positive regulation of protein kinase activity (GO:0045860)	3.61	2	BAX, FLT3
response to nitrogen compound (GO:1901698)	3.12	2	BAX, FLT3
response to steroid hormone (GO:0048545)	4.24	2	BAX, FLT3
regulation of chromatin organization (GO:1902275)	4.69	2	TAL1, PAX5
response to glucocorticoid (GO:0051384)	4.63	2	BAX, FLT3
regulation of cell activation (GO:0050865)	3.53	2	TCF3, BCR
apoptotic signaling pathway (GO:0097190)	4.12	2	NBN, BAX
peptidyl-tyrosine phosphorylation (GO:0018108)	4.48	2	BCR, FLT3
intrinsic apoptotic signaling pathway (GO:0097193)	4.69	2	NBN, BAX
negative regulation of cell cycle process (GO:0010948)	4.37	2	NBN, BAX
neuromuscular process (GO:0050905)	5.27	2	NBN, BCR
regulation of cell death (GO:0010941)	2.43	2	BAX, FLT3
cerebral cortex development (GO:0021987)	5.57	2	BAX, PAX5
gamete generation (GO:0007276)	3.61	2	BAX, PAX5
growth (GO:0040007)	3.8	2	NBN, TAL2
regulation of apoptotic process (GO:0042981)	2.5	2	BAX, FLT3
single-organism organelle organization (GO:1902589)	2.68	2	BAX, BCR
leukocyte proliferation (GO:0070661)	5.25	2	BAX, FLT3
hematopoietic progenitor cell differentiation (GO:0002244)	5.23	2	FLT3, TAL1
neurological system process (GO:0050877)	2.64	2	NBN, BCR
hematopoietic or lymphoid organ development (GO:0048534)	4.49	2	FLT3, TAL1
embryonic morphogenesis (GO:0048598)	3.72	2	BCR, PAX5
negative regulation of mitotic cell cycle (GO:0045930)	4.45	2	NBN, BAX
protein phosphorylation (GO:0006468)	2.89	2	BCR, FLT3
regulation of tissue remodeling (GO:0034103)	5.55	2	BAX, BCR
B cell differentiation (GO:0030183)	5.24	2	TCF3, FLT3
multi-organism cellular process (GO:0044764)	3.14	2	BAX, NUP214
establishment of localization in cell (GO:0051649)	2.47	2	BAX, NUP214
localization (GO:0051179)	1.4	2	BAX, NUP214
single-organism localization (GO:1902578)	2.09	2	BAX, NUP214
response to oxygen-containing compound (GO:1901700)	2.57	2	BAX, BCR
positive regulation of cell differentiation (GO:0045597)	3.01	2	TCF3, TAL1
regulation of cell cycle G1/S phase transition (GO:1902806)	4.74	2	BAX, TCF3
regulation of cellular component biogenesis (GO:0044087)	3.08	2	BAX, TAL1
phosphate-containing compound metabolic process (GO:0006796)	2.16	2	BCR, FLT3
viral process (GO:0016032)	3.15	2	BAX, NUP214
phosphorus metabolic process (GO:0006793)	2.15	2	BCR, FLT3
DNA metabolic process (GO:0006259)	3.09	2	NBN, TCF3
symbiosis, encompassing mutualism through parasitism (GO:0044403)	3.15	2	BAX, NUP214
positive regulation of cellular component biogenesis (GO:0044089)	3.71	2	BAX, TAL1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
somatic diversification of immune receptors via germline recombination within a single locus (GO:0002562)	-	6.23	0.005	NBN, TCF3, TAL1
regulation of DNA metabolic process (GO:0051052)	-	3.87	0.028	NBN, BAX, NUP214, PAX5, TCF3
cell proliferation (GO:0008283)	-	3.23	0.02	NBN, BAX, TCF3, BCR, TAL1, FLT3, PAX5
cellular response to cytokine stimulus (GO:0071345)	NEW	4.33	0.001	BAX, NUP214, TCF3, BCR, TAL1, FLT3, PAX5
anatomical structure development (GO:0048856)	-	1.58	0.03	BAX, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
B cell activation (GO:0042113)	-	4.84	0.0	NBN, BAX, FLT3, TCF3, PAX5
T cell activation (GO:0042110)	NEW	4.45	0.012	BCR, FLT3, BAX, TCF3, PAX5
tissue development (GO:0009888)	NEW	3.27	0.021	NBN, BAX, TCF3, BCR, TAL1, FLT3, PAX5
single-organism developmental process (GO:0044767)	-	1.49	0.036	NBN, BAX, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
leukocyte activation (GO:0045321)	-	3.76	0.015	NBN, BAX, TCF3, BCR, TAL1, FLT3, PAX5
cell activation (GO:0001775)	-	3.47	0.005	NBN, BAX, TCF3, BCR, TAL1, FLT3, PAX5
lymphocyte activation (GO:0046649)	-	3.96	0.0	NBN, BAX, TCF3, BCR, TAL1, FLT3, PAX5
regulation of cell cycle (GO:0051726)	-	2.93	0.001	NBN, BAX, NUP214, TCF3, BCR, TAL1, PAX5
leukocyte differentiation (GO:0002521)	-	4.13	0.03	FLT3, BCR, TAL1, TCF3, PAX5
lymphocyte differentiation (GO:0030098)	-	4.49	0.005	FLT3, BCR, TAL1, TCF3, PAX5
transcription from RNA polymerase II promoter (GO:0006366)	NEW	3.38	0.017	NBN, TCF3, TAL1, FLT3, TAL2, PAX5
somatic diversification of immune receptors (GO:0002200)	-	5.92	0.007	NBN, TCF3, TAL1
macromolecular complex assembly (GO:0065003)	NEW	2.55	0.01	BAX, NUP214, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
somatic cell DNA recombination (GO:0016444)	-	6.23	0.005	NBN, TCF3, TAL1
somatic recombination of immunoglobulin gene segments (GO:0016447)	-	6.68	0.044	NBN, TCF3
response to cytokine (GO:0034097)	NEW	3.84	0.005	BAX, NUP214, TCF3, BCR, TAL1, FLT3, PAX5

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
intracellular part (GO:0044424)	0.28	9	NBN, BAX, NUP214, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
cell part (GO:0044464)	0.11	9	NBN, BAX, NUP214, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
intracellular organelle (GO:0043229)	0.51	9	NBN, BAX, NUP214, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
membrane-bounded organelle (GO:0043227)	0.47	9	NBN, BAX, NUP214, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
organelle (GO:0043226)	0.4	9	NBN, BAX, NUP214, TCF3, BCR, TAL1, FLT3, TAL2, PAX5
nucleus (GO:0005634)	1.07	8	NBN, BAX, NUP214, TCF3, TAL1, FLT3, TAL2, PAX5
intracellular membrane-bounded organelle (GO:0043231)	0.6	8	NBN, BAX, NUP214, TCF3, TAL1, FLT3, TAL2, PAX5
protein complex (GO:0043234)	1.51	7	NBN, BAX, NUP214, TCF3, TAL1, FLT3, BCR
macromolecular complex (GO:0032991)	1.35	7	NBN, BAX, NUP214, TCF3, TAL1, FLT3, BCR
intracellular organelle part (GO:0044446)	0.81	6	NBN, BAX, NUP214, TCF3, TAL1, FLT3
organelle part (GO:0044422)	0.79	6	NBN, BAX, NUP214, TCF3, TAL1, FLT3
cytosol (GO:0005829)	1.68	5	NBN, BAX, BCR, FLT3, NUP214
nuclear part (GO:0044428)	1.55	5	NBN, BAX, TAL1, NUP214, TCF3
cytoplasmic part (GO:0044444)	0.82	5	NBN, BAX, BCR, FLT3, NUP214
cytoplasm (GO:0005737)	1.01	4	BAX, FLT3, BCR, TCF3
nucleoplasm (GO:0005654)	1.89	3	NBN, TCF3, NUP214
membrane part (GO:0044425)	0.95	3	BAX, FLT3, BCR
membrane (GO:0016020)	0.68	3	BAX, FLT3, BCR
chromosomal part (GO:0044427)	3.18	3	NBN, TCF3, TAL1
nuclear chromosome part (GO:0044454)	3.67	3	NBN, TCF3, TAL1
extracellular vesicle (GO:1903561)	1.89	2	BAX, BCR
extracellular organelle (GO:0043230)	1.89	2	BAX, BCR
endoplasmic reticulum (GO:0005783)	2.56	2	BAX, FLT3
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	2	NBN, BCR
extracellular exosome (GO:0070062)	1.89	2	BAX, BCR
integral component of membrane (GO:0016021)	1.14	2	BAX, FLT3
membrane-bounded vesicle (GO:0031988)	1.71	2	BAX, BCR
endoplasmic reticulum part (GO:0044432)	2.73	2	BAX, FLT3
nuclear chromatin (GO:0000790)	4.42	2	TCF3, TAL1
non-membrane-bounded organelle (GO:0043228)	1.76	2	NBN, BCR
chromatin (GO:0000785)	3.99	2	TCF3, TAL1
intrinsic component of membrane (GO:0031224)	1.13	2	BAX, FLT3
transcription factor complex (GO:0005667)	4.1	2	TCF3, TAL1
plasma membrane (GO:0005886)	1.39	2	BCR, FLT3
nucleoplasm part (GO:0044451)	3.22	2	NBN, TAL1
intracellular (GO:0005622)	2.37	2	BAX, BCR
plasma membrane part (GO:0044459)	1.95	2	BCR, FLT3
extracellular region part (GO:0044421)	1.57	2	BAX, BCR
cell junction (GO:0030054)	2.75	2	BCR, NUP214
vesicle (GO:0031982)	1.64	2	BAX, BCR

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
pore complex (GO:0046930)	NEW	6.97	0.035	BAX, NUP214
organelle membrane (GO:0031090)	NEW	1.97	0.022	NBN, BAX, NUP214, TCF3, BCR, TAL1, FLT3, PAX5
nuclear chromosome part (GO:0044454)	-	3.67	0.019	NBN, TCF3, TAL1
nucleoplasm part (GO:0044451)	-	3.22	0.033	NBN, TAL1, PAX5, NUP214, TCF3