Disease table of BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO OMIM ID: PS604370

Gene-disease associations table

GeneAssociated with BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
BRCA1ClinVar, OMIM, HUMSAVARHGNC link17q21.315PS227650, 167000, 614320, PS604370, 114480
RAD51DClinVar, OMIMHGNC link17q121PS604370
BRCA2ClinVar, OMIMHGNC link13q13.18PS227650, PS194070, 155255, 114480, 176807, PS137800, 613347, PS604370
RAD51CClinVar, OMIM, HUMSAVARHGNC link17q222PS227650, PS604370

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
17q22BRCA1, RAD51C
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
17q3BRCA1, RAD51D, RAD51C
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
173BRCA1, RAD51D, RAD51C
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
BRCA1YES52ATM, RNASEL, DDIT3, KRT5, JAK2, MAD2L1, IRF7, EGFR, HSPA5, FOS, XPC, STAT2, EGR1, CCND1, AREG, FST, HNRNPA2B1, STAT1, CASR, E2F6, ESR1, SIRT1, DDB2, CDKN1A, KRT18, CXCL1, FOXC1, FOXC2, IFNA1, CDH3, CYP1A1, CTSD, IGF1, KHSRP, CYP19A1, HMGA2, EP300, KRT17, TFF1, STAT3, BRCA2, ASPM, TP63, IGF1R, GADD45A, JAK1, CDKN1B, CCNB1, MYC, VEGFA, IRF9, HIF1A1BRCA2
USF2NO42PF4, FCER1A, CTSB, IGF2R, NR5A1, CEACAM1, MYH9, TRAP, ASPH, CEACAM5, TOP3A, PTGS2, PDX1, CYP19A1, HOXB4, THBS1, CFTR, TCN2, TGFB1, PKLR, FMR1, SLC19A1, APC, CD2, TGFB2, PIGR, CTSD, ASCL2, PTPN6, CXCR4, BRCA1, FBP1, BRCA2, CXCR2, ATP5A1, APOA2, APOA5, B2M, HMOX1, TERT, ABCA1, LIPC2BRCA1, BRCA2
TP53NO159ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING12BRCA1, BRCA2
CTBP1NO4BRCA2, BRCA1, CLDN7, KRT182BRCA1, BRCA2
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
BRCA1YES33WWP1, RBL2, EZH2, DLX4, CTBP1, SP1, E2F4, ID4, NCOA3, USF2, MTA1, E2F1, FOSL2, RBL1, FOXP3, IFI16, NFE2L2, SP100, TP53, CTCF, EP300, ETS1, E2F6, NR3C1, YY1, JUN, TP53BP1, RB1, HMGA1, ESR1, AHR, CREBBP, FOXA10
BRCA2YES11ESR2, CTBP1, HDAC1, ELF1, TP53, USF2, RELA, PARP1, BRCA1, NFKB1, USF11BRCA1
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
BRCA1RAD51DNo4BLM, HUWE1, CEP57L1, RAD51
BRCA1BRCA2Yes29ATM, BRE, FANCD2, SHFM1, H2AFX, CCNA2, SP1, ATR, BACH1, RPA1, STAT5A, SMAD3, BRCA1, RAD21, PALB2, MORF4L1, BARD1, PMS2, TP53, PCNA, SMC3, CHEK2, BRCC3, HNRNPC, CDK2, FLNA, PLK1, POLH, RAD51
BRCA1RAD51CNo1RAD51
RAD51DBRCA2No1RAD51
RAD51DRAD51CYes5XRCC2, RAD51B, HHV8GK18_GP81, SWSAP1, RAD51
BRCA2RAD51CNo2RAD51, XRCC3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
BRCA1RAD51DNo-11MSH3, BRCA2, MSH2, ACACA, RPA1, BLM, TP53BP1, RAD51B, UBE2I, MSH6, RAD51C
BRCA1BRCA2Yesbinding32AR, TREX1, H2AFX, FANCD2, SHFM1, TEX15, HIST3H3, RPA3, RAD51B, ATR, MLH1, RAD51, RPA1, STAT5A, SMAD3, RPA2, PALB2, FANCI, DMC1, TP53, PSMC3IP, BRIP1, FANCA, CDK2, CDK4, BUB1B, PLK1, BLM, FANCG, MND1, CHEK2, RAD51C
BRCA1RAD51CYesactivation, binding15ACACA, BRCA2, RPA2, RAD51B, PALB2, RPA1, PSMC3IP, DMC1, CDK4, MND1, RPA3, HIST3H3, H2AFX, MLH1, RAD51
RAD51DBRCA2Yesactivation, binding6RPA1, BLM, XRCC3, RAD51B, TOP3A, RAD51C
RAD51DRAD51CYesactivation, binding13ACACA, BRCA2, XRCC3, XRCC2, RPA1, RAD54B, ACACB, SWI5, SFR1, RAD52, RAD54L, RAD51B, HELQ
BRCA2RAD51CYesactivation, binding17XRCC3, HIST3H3, RPA2, RAD51D, H2AFX, PALB2, RAD51, RPA1, RAD51B, PSMC3IP, DMC1, CDK4, MND1, RPA3, BRCA1, MLH1, MLH3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
BRCA1RAD51DNo-1BLM
BRCA1BRCA2YesBRCC complex;BRCA1-BARD1-BRCA2-DNA damage complex III6BRE, HDAC2, HDAC1, BARD1, BRCC3, RAD51
RAD51DRAD51CYesBCDX2 complex;RAD51B-RAD51C-RAD51D-XRCC2-XRCC3 complex3RAD51B, XRCC2, XRCC3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Homologous recombinationhsa034407.913BRCA2, RAD51C, RAD51D
Fanconi anemia pathwayhsa034607.013BRCA1, BRCA2, RAD51C

NET-GE enrichment

Term New enriched termICP valueGenes
Homologous recombination (hsa03440) -7.910.0BRCA2, RAD51C, RAD51D
Fanconi anemia pathway (hsa03460) -7.010.0BRCA1, BRCA2, RAD51C
Genetic Information ProcessingNEW2.480.017BRCA1, BRCA2, RAD51C, RAD51D
Replication and repairNEW5.410.0BRCA1, BRCA2, RAD51C, RAD51D
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Cell CycleR-HSA-16401703.893BRCA1, BRCA2, RAD51C
MeiosisR-HSA-15006206.593BRCA1, BRCA2, RAD51C
Meiotic recombinationR-HSA-9124467.253BRCA1, BRCA2, RAD51C
DNA RepairR-HSA-738945.82BRCA1, BRCA2
Double-Strand Break RepairR-HSA-738908.462BRCA1, BRCA2
Fanconi Anemia pathwayR-HSA-4195248.42BRCA1, BRCA2
Homologous recombination repair of replication-independent double-strand breaksR-HSA-739518.982BRCA1, BRCA2
Homologous Recombination RepairR-HSA-738888.982BRCA1, BRCA2

NET-GE enrichment

Term New enriched termICP valueGenes
DNA Repair (R-HSA-73894) -5.80.024BRCA1, BRCA2
Homologous recombination repair of replication-independent double-strand breaks (R-HSA-73951) -8.980.0BRCA1, BRCA2
Meiotic recombination (R-HSA-912446) -7.250.0BRCA1, BRCA2, RAD51C
Meiosis (R-HSA-1500620) -6.590.0BRCA1, BRCA2, RAD51C
Cell Cycle (R-HSA-1640170) -3.890.008BRCA1, BRCA2, RAD51C
Homologous Recombination Repair (R-HSA-73888) -8.980.0BRCA1, BRCA2
Double-Strand Break Repair (R-HSA-73890) -8.460.001BRCA1, BRCA2
Fanconi Anemia pathway (R-HSA-419524) -8.40.002BRCA1, BRCA2
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
protein binding (GO:0005515) 0.464BRCA1, BRCA2, RAD51C, RAD51D
organic cyclic compound binding (GO:0097159) 1.054BRCA1, BRCA2, RAD51C, RAD51D
catalytic activity (GO:0003824) 1.054BRCA1, BRCA2, RAD51C, RAD51D
binding (GO:0005488) 0.184BRCA1, BRCA2, RAD51C, RAD51D
nucleic acid binding (GO:0003676) 1.444BRCA1, BRCA2, RAD51C, RAD51D
DNA binding (GO:0003677) 1.924BRCA1, BRCA2, RAD51C, RAD51D
heterocyclic compound binding (GO:1901363) 1.064BRCA1, BRCA2, RAD51C, RAD51D
tubulin binding (GO:0015631) 4.13BRCA1, BRCA2, RAD51D
single-stranded DNA binding (GO:0003697) 5.173BRCA2, RAD51C, RAD51D
cytoskeletal protein binding (GO:0008092) 3.023BRCA1, BRCA2, RAD51D
purine ribonucleoside triphosphate binding (GO:0035639) 2.222RAD51C, RAD51D
enzyme binding (GO:0019899) 2.272BRCA1, BRCA2
ATPase activity (GO:0016887) 3.652RAD51C, RAD51D
nucleoside phosphate binding (GO:1901265) 1.962RAD51C, RAD51D
nucleoside binding (GO:0001882) 2.212RAD51C, RAD51D
structure-specific DNA binding (GO:0043566) 4.982RAD51C, RAD51D
ATPase activity, coupled (GO:0042623) 3.972RAD51C, RAD51D
endodeoxyribonuclease activity (GO:0004520) 5.812RAD51C, RAD51D
nucleotide binding (GO:0000166) 1.962RAD51C, RAD51D
transferase activity (GO:0016740) 1.952BRCA1, BRCA2
purine nucleoside binding (GO:0001883) 2.222RAD51C, RAD51D
ribonucleoside binding (GO:0032549) 2.222RAD51C, RAD51D
purine nucleotide binding (GO:0017076) 2.192RAD51C, RAD51D
double-stranded DNA binding (GO:0003690) 3.092RAD51C, RAD51D
ATP binding (GO:0005524) 2.432RAD51C, RAD51D
hydrolase activity (GO:0016787) 1.92RAD51C, RAD51D
DNA secondary structure binding (GO:0000217) 6.62RAD51C, RAD51D
four-way junction DNA binding (GO:0000400) 7.032RAD51C, RAD51D
hydrolase activity, acting on ester bonds (GO:0016788) 3.12RAD51C, RAD51D
nucleoside-triphosphatase activity (GO:0017111) 3.092RAD51C, RAD51D
small molecule binding (GO:0036094) 1.892RAD51C, RAD51D
nuclease activity (GO:0004518) 4.332RAD51C, RAD51D
DNA-dependent ATPase activity (GO:0008094) 5.312RAD51C, RAD51D
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 3.032RAD51C, RAD51D
adenyl nucleotide binding (GO:0030554) 2.42RAD51C, RAD51D
carbohydrate derivative binding (GO:0097367) 2.032RAD51C, RAD51D
endonuclease activity (GO:0004519) 4.782RAD51C, RAD51D
recombinase activity (GO:0000150) 7.662RAD51C, RAD51D
hydrolase activity, acting on acid anhydrides (GO:0016817) 3.032RAD51C, RAD51D
deoxyribonuclease activity (GO:0004536) 5.482RAD51C, RAD51D
adenyl ribonucleotide binding (GO:0032559) 2.412RAD51C, RAD51D
purine ribonucleotide binding (GO:0032555) 2.22RAD51C, RAD51D
gamma-tubulin binding (GO:0043015) 6.562BRCA2, RAD51D
pyrophosphatase activity (GO:0016462) 3.042RAD51C, RAD51D
purine ribonucleoside binding (GO:0032550) 2.222RAD51C, RAD51D
ribonucleotide binding (GO:0032553) 2.192RAD51C, RAD51D

NET-GE enrichment

Term New enriched termICP valueGenes
DNA-dependent ATPase activity (GO:0008094) -5.310.007RAD51C, RAD51D
tubulin binding (GO:0015631) -4.10.001BRCA1, BRCA2, RAD51D
cytoskeletal protein binding (GO:0008092) -3.020.026BRCA1, BRCA2, RAD51D
DNA binding (GO:0003677) -1.920.03BRCA1, BRCA2, RAD51C, RAD51D
gamma-tubulin binding (GO:0043015) -6.560.001BRCA1, BRCA2, RAD51D
single-stranded DNA binding (GO:0003697) -5.170.007BRCA2, RAD51D
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
primary metabolic process (GO:0044238) 0.694BRCA1, BRCA2, RAD51C, RAD51D
response to radiation (GO:0009314) 3.694BRCA1, BRCA2, RAD51C, RAD51D
nucleic acid metabolic process (GO:0090304) 1.464BRCA1, BRCA2, RAD51C, RAD51D
cellular biosynthetic process (GO:0044249) 1.374BRCA1, BRCA2, RAD51C, RAD51D
cellular nitrogen compound metabolic process (GO:0034641) 1.224BRCA1, BRCA2, RAD51C, RAD51D
nitrogen compound metabolic process (GO:0006807) 1.134BRCA1, BRCA2, RAD51C, RAD51D
cell cycle process (GO:0022402) 2.754BRCA1, BRCA2, RAD51C, RAD51D
strand displacement (GO:0000732) 6.474BRCA1, BRCA2, RAD51C, RAD51D
cellular macromolecule biosynthetic process (GO:0034645) 1.664BRCA1, BRCA2, RAD51C, RAD51D
organic substance biosynthetic process (GO:1901576) 1.344BRCA1, BRCA2, RAD51C, RAD51D
organic cyclic compound biosynthetic process (GO:1901362) 1.664BRCA1, BRCA2, RAD51C, RAD51D
regulation of biological process (GO:0050789) 0.454BRCA1, BRCA2, RAD51C, RAD51D
cellular component organization or biogenesis (GO:0071840) 1.224BRCA1, BRCA2, RAD51C, RAD51D
nucleobase-containing compound metabolic process (GO:0006139) 1.354BRCA1, BRCA2, RAD51C, RAD51D
cellular response to stimulus (GO:0051716) 1.974BRCA1, BRCA2, RAD51C, RAD51D
response to ionizing radiation (GO:0010212) 4.744BRCA1, BRCA2, RAD51C, RAD51D
double-strand break repair (GO:0006302) 4.734BRCA1, BRCA2, RAD51C, RAD51D
cellular macromolecule metabolic process (GO:0044260) 0.934BRCA1, BRCA2, RAD51C, RAD51D
double-strand break repair via homologous recombination (GO:0000724) 5.384BRCA1, BRCA2, RAD51C, RAD51D
cellular component organization (GO:0016043) 1.244BRCA1, BRCA2, RAD51C, RAD51D
organic substance metabolic process (GO:0071704) 0.634BRCA1, BRCA2, RAD51C, RAD51D
biological regulation (GO:0065007) 0.394BRCA1, BRCA2, RAD51C, RAD51D
organic cyclic compound metabolic process (GO:1901360) 1.264BRCA1, BRCA2, RAD51C, RAD51D
heterocycle biosynthetic process (GO:0018130) 1.74BRCA1, BRCA2, RAD51C, RAD51D
DNA recombination (GO:0006310) 4.394BRCA1, BRCA2, RAD51C, RAD51D
biosynthetic process (GO:0009058) 1.324BRCA1, BRCA2, RAD51C, RAD51D
DNA repair (GO:0006281) 3.594BRCA1, BRCA2, RAD51C, RAD51D
cellular process (GO:0009987) 0.264BRCA1, BRCA2, RAD51C, RAD51D
cellular aromatic compound metabolic process (GO:0006725) 1.34BRCA1, BRCA2, RAD51C, RAD51D
regulation of cellular process (GO:0050794) 0.54BRCA1, BRCA2, RAD51C, RAD51D
cellular response to DNA damage stimulus (GO:0006974) 3.174BRCA1, BRCA2, RAD51C, RAD51D
response to stress (GO:0006950) 1.84BRCA1, BRCA2, RAD51C, RAD51D
macromolecule biosynthetic process (GO:0009059) 1.614BRCA1, BRCA2, RAD51C, RAD51D
metabolic process (GO:0008152) 0.584BRCA1, BRCA2, RAD51C, RAD51D
nucleobase-containing compound biosynthetic process (GO:0034654) 1.724BRCA1, BRCA2, RAD51C, RAD51D
heterocycle metabolic process (GO:0046483) 1.314BRCA1, BRCA2, RAD51C, RAD51D
organelle organization (GO:0006996) 2.024BRCA1, BRCA2, RAD51C, RAD51D
response to abiotic stimulus (GO:0009628) 2.84BRCA1, BRCA2, RAD51C, RAD51D
cellular nitrogen compound biosynthetic process (GO:0044271) 1.594BRCA1, BRCA2, RAD51C, RAD51D
chromosome organization (GO:0051276) 3.794BRCA1, BRCA2, RAD51C, RAD51D
regulation of cell cycle (GO:0051726) 2.934BRCA1, BRCA2, RAD51C, RAD51D
response to stimulus (GO:0050896) 1.224BRCA1, BRCA2, RAD51C, RAD51D
DNA synthesis involved in DNA repair (GO:0000731) 5.424BRCA1, BRCA2, RAD51C, RAD51D
cellular metabolic process (GO:0044237) 0.694BRCA1, BRCA2, RAD51C, RAD51D
macromolecule metabolic process (GO:0043170) 0.834BRCA1, BRCA2, RAD51C, RAD51D
recombinational repair (GO:0000725) 5.374BRCA1, BRCA2, RAD51C, RAD51D
cellular response to stress (GO:0033554) 2.514BRCA1, BRCA2, RAD51C, RAD51D
DNA metabolic process (GO:0006259) 3.094BRCA1, BRCA2, RAD51C, RAD51D
aromatic compound biosynthetic process (GO:0019438) 1.74BRCA1, BRCA2, RAD51C, RAD51D
DNA biosynthetic process (GO:0071897) 4.894BRCA1, BRCA2, RAD51C, RAD51D
telomere maintenance (GO:0000723) 5.373BRCA2, RAD51C, RAD51D
mitotic recombination (GO:0006312) 6.043BRCA2, RAD51C, RAD51D
multicellular organismal process (GO:0032501) 1.453BRCA1, BRCA2, RAD51C
positive regulation of cell cycle (GO:0045787) 3.943BRCA1, BRCA2, RAD51C
single-multicellular organism process (GO:0044707) 1.783BRCA1, BRCA2, RAD51C
anatomical structure homeostasis (GO:0060249) 4.253BRCA2, RAD51C, RAD51D
macromolecular complex subunit organization (GO:0043933) 2.143BRCA2, RAD51C, RAD51D
regulation of cell cycle process (GO:0010564) 3.53BRCA1, BRCA2, RAD51C
telomere organization (GO:0032200) 5.333BRCA2, RAD51C, RAD51D
meiotic cell cycle process (GO:1903046) 4.713BRCA2, RAD51C, RAD51D
homeostatic process (GO:0042592) 2.613BRCA2, RAD51C, RAD51D
reproductive process (GO:0022414) 2.553BRCA2, RAD51C, RAD51D
positive regulation of biological process (GO:0048518) 1.23BRCA1, BRCA2, RAD51C
regulation of biological quality (GO:0065008) 1.683BRCA2, RAD51C, RAD51D
single-organism process (GO:0044699) 0.483BRCA1, BRCA2, RAD51C
positive regulation of cellular process (GO:0048522) 1.33BRCA1, BRCA2, RAD51C
regulation of primary metabolic process (GO:0080090) 1.082BRCA1, BRCA2
regulation of metabolic process (GO:0019222) 1.022BRCA1, BRCA2
chromosome breakage (GO:0031052) 8.342BRCA1, BRCA2
signal transduction (GO:0007165) 1.282BRCA1, BRCA2
negative regulation of macromolecule metabolic process (GO:0010605) 2.012BRCA1, BRCA2
positive regulation of macromolecule metabolic process (GO:0010604) 1.812BRCA1, BRCA2
regulation of cellular metabolic process (GO:0031323) 1.072BRCA1, BRCA2
peptidyl-amino acid modification (GO:0018193) 2.982BRCA1, BRCA2
animal organ development (GO:0048513) 2.532BRCA1, BRCA2
negative regulation of biological process (GO:0048519) 1.332BRCA1, BRCA2
regulation of cell proliferation (GO:0042127) 2.412BRCA1, BRCA2
regulation of DNA metabolic process (GO:0051052) 3.872BRCA1, BRCA2
regulation of macromolecule metabolic process (GO:0060255) 1.082BRCA1, BRCA2
centrosome organization (GO:0051297) 5.382BRCA1, BRCA2
nucleotide-excision repair (GO:0006289) 5.052BRCA2, RAD51D
spermatogenesis (GO:0007283) 3.72BRCA2, RAD51C
regulation of RNA biosynthetic process (GO:2001141) 1.552BRCA1, BRCA2
response to organic substance (GO:0010033) 2.22BRCA1, BRCA2
single organism reproductive process (GO:0044702) 2.732BRCA2, RAD51C
response to external stimulus (GO:0009605) 2.552BRCA1, BRCA2
protein metabolic process (GO:0019538) 1.452BRCA1, BRCA2
response to nutrient levels (GO:0031667) 3.772BRCA1, BRCA2
peptidyl-lysine modification (GO:0018205) 3.982BRCA1, BRCA2
cellular component assembly (GO:0022607) 2.142RAD51C, RAD51D
negative regulation of metabolic process (GO:0009892) 1.932BRCA1, BRCA2
positive regulation of metabolic process (GO:0009893) 1.742BRCA1, BRCA2
negative regulation of biosynthetic process (GO:0009890) 2.472BRCA1, BRCA2
positive regulation of biosynthetic process (GO:0009891) 2.292BRCA1, BRCA2
positive regulation of gene expression (GO:0010628) 2.352BRCA1, BRCA2
intracellular signal transduction (GO:0035556) 2.392BRCA1, BRCA2
signal transduction by p53 class mediator (GO:0072331) 4.882BRCA1, BRCA2
cellular protein metabolic process (GO:0044267) 1.632BRCA1, BRCA2
regulation of mitotic cell cycle (GO:0007346) 3.712BRCA2, RAD51C
macromolecular complex assembly (GO:0065003) 2.552RAD51C, RAD51D
response to organic cyclic compound (GO:0014070) 3.072BRCA1, BRCA2
protein-DNA complex assembly (GO:0065004) 4.62RAD51C, RAD51D
regulation of developmental process (GO:0050793) 2.12BRCA1, BRCA2
regulation of biosynthetic process (GO:0009889) 1.372BRCA1, BRCA2
macromolecule modification (GO:0043412) 1.732BRCA1, BRCA2
protein modification process (GO:0036211) 1.792BRCA1, BRCA2
regulation of multicellular organismal process (GO:0051239) 1.872BRCA1, BRCA2
strand invasion (GO:0042148) 7.782RAD51C, RAD51D
brain development (GO:0007420) 4.242BRCA1, BRCA2
DNA recombinase assembly (GO:0000730) 7.532RAD51C, RAD51D
regulation of transcription, DNA-templated (GO:0006355) 1.562BRCA1, BRCA2
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392BRCA1, BRCA2
regulation of macromolecule biosynthetic process (GO:0010556) 1.432BRCA1, BRCA2
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532BRCA1, BRCA2
embryo development (GO:0009790) 4.22BRCA1, BRCA2
embryo development ending in birth or egg hatching (GO:0009792) 4.352BRCA1, BRCA2
cell cycle (GO:0007049) 3.142BRCA1, BRCA2
telomere maintenance via recombination (GO:0000722) 6.262BRCA2, RAD51C
meiotic nuclear division (GO:0007126) 5.372BRCA2, RAD51C
meiosis I (GO:0007127) 6.472BRCA2, RAD51C
nuclear division (GO:0000280) 3.852BRCA2, RAD51C
chordate embryonic development (GO:0043009) 4.382BRCA1, BRCA2
developmental process (GO:0032502) 1.362BRCA1, BRCA2
microtubule organizing center organization (GO:0031023) 5.262BRCA1, BRCA2
multicellular organismal reproductive process (GO:0048609) 3.352BRCA2, RAD51C
positive regulation of cell cycle process (GO:0090068) 4.252BRCA1, RAD51C
regulation of nucleic acid-templated transcription (GO:1903506) 1.552BRCA1, BRCA2
positive regulation of transcription, DNA-templated (GO:0045893) 2.562BRCA1, BRCA2
male gamete generation (GO:0048232) 3.72BRCA2, RAD51C
reciprocal meiotic recombination (GO:0007131) 6.332RAD51C, RAD51D
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator (GO:0006978) 7.092BRCA1, BRCA2
intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630) 5.442BRCA1, BRCA2
regulation of RNA metabolic process (GO:0051252) 1.522BRCA1, BRCA2
positive regulation of RNA metabolic process (GO:0051254) 2.512BRCA1, BRCA2
positive regulation of RNA biosynthetic process (GO:1902680) 2.542BRCA1, BRCA2
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562BRCA1, BRCA2
response to extracellular stimulus (GO:0009991) 3.712BRCA1, BRCA2
positive regulation of cellular biosynthetic process (GO:0031328) 2.32BRCA1, BRCA2
negative regulation of cellular biosynthetic process (GO:0031327) 2.492BRCA1, BRCA2
regulation of cellular biosynthetic process (GO:0031326) 1.382BRCA1, BRCA2
positive regulation of cellular metabolic process (GO:0031325) 1.812BRCA1, BRCA2
negative regulation of cellular metabolic process (GO:0031324) 2.012BRCA1, BRCA2
apoptotic signaling pathway (GO:0097190) 4.122BRCA1, BRCA2
intrinsic apoptotic signaling pathway (GO:0097193) 4.692BRCA1, BRCA2
cellular macromolecular complex assembly (GO:0034622) 3.182RAD51C, RAD51D
multicellular organism development (GO:0007275) 2.542BRCA1, BRCA2
gamete generation (GO:0007276) 3.612BRCA2, RAD51C
male meiosis I (GO:0007141) 6.92BRCA2, RAD51C
protein-DNA complex subunit organization (GO:0071824) 4.452RAD51C, RAD51D
response to estradiol (GO:0032355) 4.732BRCA1, BRCA2
response to lipid (GO:0033993) 3.112BRCA1, BRCA2
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462BRCA1, BRCA2
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62BRCA1, BRCA2
regulation of gene expression (GO:0010468) 1.372BRCA1, BRCA2
positive regulation of mitotic cell cycle (GO:0045931) 4.982BRCA2, RAD51C
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352BRCA1, BRCA2
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.552BRCA1, BRCA2
DNA damage response, signal transduction by p53 class mediator (GO:0030330) 5.32BRCA1, BRCA2
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432BRCA1, BRCA2
response to nutrient (GO:0007584) 4.492BRCA1, BRCA2
cellular protein modification process (GO:0006464) 1.792BRCA1, BRCA2
single-organism developmental process (GO:0044767) 1.492BRCA1, BRCA2
single-organism cellular process (GO:0044763) 0.652BRCA1, BRCA2
regulation of nitrogen compound metabolic process (GO:0051171) 1.362BRCA1, BRCA2
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472BRCA1, BRCA2
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292BRCA1, BRCA2
response to chemical (GO:0042221) 1.982BRCA1, BRCA2
DNA damage response, signal transduction resulting in transcription (GO:0042772) 7.022BRCA1, BRCA2
signal transduction in response to DNA damage (GO:0042770) 5.152BRCA1, BRCA2
response to oxygen-containing compound (GO:1901700) 2.572BRCA1, BRCA2
anatomical structure development (GO:0048856) 1.582BRCA1, BRCA2
regulation of multicellular organismal development (GO:2000026) 2.312BRCA1, BRCA2
organelle fission (GO:0048285) 3.792BRCA2, RAD51C
reciprocal DNA recombination (GO:0035825) 6.332RAD51C, RAD51D
negative regulation of cellular process (GO:0048523) 1.412BRCA1, BRCA2

NET-GE enrichment

Term New enriched termICP valueGenes
meiotic cell cycle process (GO:1903046) -4.710.0BRCA1, BRCA2, RAD51C, RAD51D
purine ribonucleoside monophosphate metabolic process (GO:0009167) NEW4.70.009BRCA1, BRCA2, RAD51C, RAD51D
purine nucleoside monophosphate catabolic process (GO:0009128) NEW7.940.004BRCA1, BRCA2, RAD51C, RAD51D
cell cycle process (GO:0022402) -2.750.004BRCA1, BRCA2, RAD51C, RAD51D
glutamine family amino acid catabolic process (GO:0009065) NEW6.550.034BRCA1, RAD51D
ribonucleoside monophosphate metabolic process (GO:0009161) NEW4.620.011BRCA1, BRCA2, RAD51C, RAD51D
nucleoside monophosphate metabolic process (GO:0009123) NEW4.540.011BRCA1, BRCA2, RAD51C, RAD51D
purine nucleoside monophosphate metabolic process (GO:0009126) NEW4.690.009BRCA1, BRCA2, RAD51C, RAD51D
purine ribonucleoside monophosphate catabolic process (GO:0009169) NEW8.120.004BRCA1, BRCA2, RAD51C, RAD51D
meiotic nuclear division (GO:0007126) -5.370.011BRCA1, BRCA2, RAD51C
cellular macromolecule catabolic process (GO:0044265) NEW3.190.046BRCA1, BRCA2, RAD51C, RAD51D
double-strand break repair (GO:0006302) -4.730.0BRCA1, BRCA2, RAD51C, RAD51D
recombinational repair (GO:0000725) -5.370.0BRCA1, BRCA2, RAD51C, RAD51D
double-strand break repair via homologous recombination (GO:0000724) -5.380.0BRCA1, BRCA2, RAD51C, RAD51D
DNA damage response, signal transduction resulting in transcription (GO:0042772) -7.020.002BRCA1, BRCA2
male meiosis I (GO:0007141) -6.90.002BRCA1, BRCA2, RAD51C
ribonucleoside monophosphate catabolic process (GO:0009158) NEW8.120.004BRCA1, BRCA2, RAD51C, RAD51D
regulation of cell cycle process (GO:0010564) -3.50.032BRCA1, BRCA2, RAD51C
nucleoside monophosphate catabolic process (GO:0009125) NEW7.650.004BRCA1, BRCA2, RAD51C, RAD51D
positive regulation of mitotic cell cycle (GO:0045931) -4.980.012BRCA2, RAD51C
DNA recombination (GO:0006310) -4.390.0BRCA1, BRCA2, RAD51C, RAD51D
microtubule organizing center organization (GO:0031023) -5.260.043BRCA1, BRCA2
DNA repair (GO:0006281) -3.590.0BRCA1, BRCA2, RAD51C, RAD51D
ATP metabolic process (GO:0046034) NEW4.980.007BRCA1, BRCA2, RAD51C, RAD51D
centrosome organization (GO:0051297) -5.380.035BRCA1, BRCA2
cellular response to DNA damage stimulus (GO:0006974) -3.170.001BRCA1, BRCA2, RAD51C, RAD51D
meiosis I (GO:0007127) -6.470.004BRCA1, BRCA2, RAD51C
reciprocal meiotic recombination (GO:0007131) -6.330.046RAD51C, RAD51D
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator (GO:0006978) -7.090.001BRCA1, BRCA2
organelle organization (GO:0006996) -2.020.049BRCA1, BRCA2, RAD51C, RAD51D
inner cell mass cell proliferation (GO:0001833) NEW7.330.008BRCA1, BRCA2
single-organism organelle organization (GO:1902589) NEW2.680.013BRCA1, BRCA2, RAD51C, RAD51D
cellular response to stress (GO:0033554) -2.510.009BRCA1, BRCA2, RAD51C, RAD51D
DNA metabolic process (GO:0006259) -3.090.002BRCA1, BRCA2, RAD51C, RAD51D
reciprocal DNA recombination (GO:0035825) -6.330.046RAD51C, RAD51D
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cytoplasm (GO:0005737) 1.014BRCA1, BRCA2, RAD51C, RAD51D
protein complex (GO:0043234) 1.514BRCA1, BRCA2, RAD51C, RAD51D
macromolecular complex (GO:0032991) 1.354BRCA1, BRCA2, RAD51C, RAD51D
intracellular membrane-bounded organelle (GO:0043231) 0.64BRCA1, BRCA2, RAD51C, RAD51D
intracellular non-membrane-bounded organelle (GO:0043232) 1.764BRCA1, BRCA2, RAD51C, RAD51D
nucleus (GO:0005634) 1.074BRCA1, BRCA2, RAD51C, RAD51D
cell part (GO:0044464) 0.114BRCA1, BRCA2, RAD51C, RAD51D
intracellular organelle part (GO:0044446) 0.814BRCA1, BRCA2, RAD51C, RAD51D
nucleoplasm (GO:0005654) 1.894BRCA1, BRCA2, RAD51C, RAD51D
intracellular organelle (GO:0043229) 0.514BRCA1, BRCA2, RAD51C, RAD51D
non-membrane-bounded organelle (GO:0043228) 1.764BRCA1, BRCA2, RAD51C, RAD51D
nuclear part (GO:0044428) 1.554BRCA1, BRCA2, RAD51C, RAD51D
intracellular part (GO:0044424) 0.284BRCA1, BRCA2, RAD51C, RAD51D
membrane-bounded organelle (GO:0043227) 0.474BRCA1, BRCA2, RAD51C, RAD51D
organelle (GO:0043226) 0.44BRCA1, BRCA2, RAD51C, RAD51D
organelle part (GO:0044422) 0.794BRCA1, BRCA2, RAD51C, RAD51D
cytoplasmic part (GO:0044444) 0.823BRCA1, BRCA2, RAD51C
cytoskeletal part (GO:0044430) 2.493BRCA1, BRCA2, RAD51D
chromosome (GO:0005694) 3.783BRCA1, RAD51C, RAD51D
chromosomal part (GO:0044427) 3.183BRCA2, RAD51C, RAD51D
cytoskeleton (GO:0005856) 2.552BRCA2, RAD51D
Rad51B-Rad51C-Rad51D-XRCC2 complex (GO:0033063) 8.192RAD51C, RAD51D
DNA recombinase mediator complex (GO:0033061) 7.862RAD51C, RAD51D
condensed chromosome (GO:0000793) 5.642BRCA1, RAD51C
centrosome (GO:0005813) 3.752BRCA2, RAD51D
integral component of membrane (GO:0016021) 1.142BRCA1, BRCA2
membrane (GO:0016020) 0.682BRCA1, BRCA2
microtubule organizing center (GO:0005815) 3.422BRCA2, RAD51D
chromosome, telomeric region (GO:0000781) 4.92BRCA2, RAD51D
nuclear chromosome part (GO:0044454) 3.672BRCA2, RAD51D
replication fork (GO:0005657) 6.622RAD51C, RAD51D
chromosomal region (GO:0098687) 4.192BRCA2, RAD51D
condensed nuclear chromosome (GO:0000794) 6.112BRCA1, RAD51C
membrane part (GO:0044425) 0.952BRCA1, BRCA2
nuclear chromosome (GO:0000228) 5.552BRCA1, RAD51C
intrinsic component of membrane (GO:0031224) 1.132BRCA1, BRCA2
nuclear chromosome, telomeric region (GO:0000784) 5.162BRCA2, RAD51D

NET-GE enrichment

Term New enriched termICP valueGenes
Rad51B-Rad51C-Rad51D-XRCC2 complex (GO:0033063) -8.190.0RAD51C, RAD51D
DNA recombinase mediator complex (GO:0033061) -7.860.0RAD51C, RAD51D
microbody membrane (GO:0031903) NEW5.760.01BRCA1, RAD51D
peroxisomal membrane (GO:0005778) NEW5.760.01BRCA1, RAD51D
microtubule organizing center (GO:0005815) -3.420.004BRCA1, BRCA2, RAD51C, RAD51D
nucleoplasm (GO:0005654) -1.890.037BRCA1, BRCA2, RAD51C
replication fork (GO:0005657) -6.620.001RAD51C, RAD51D
nuclear part (GO:0044428) -1.550.018BRCA1, BRCA2, RAD51C, RAD51D
centrosome (GO:0005813) -3.750.001BRCA1, BRCA2, RAD51C, RAD51D
peroxisomal part (GO:0044439) NEW5.280.032BRCA1, RAD51D
microbody part (GO:0044438) NEW5.280.032BRCA1, RAD51D
chromosomal part (GO:0044427) -3.180.005BRCA1, BRCA2, RAD51C, RAD51D