Disease table of FANCONI ANEMIA OMIM ID: PS227650

Gene-disease associations table

Gene	Associated with FANCONI ANEMIA in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
BRCA1	ClinVar	HGNC link	17q21.31	5	PS227650, 167000, 614320, PS604370, 114480
BRCA2	ClinVar, OMIM, HUMSAVAR	HGNC link	13q13.1	8	PS227650, PS194070, 155255, 114480, 176807, PS137800, 613347, PS604370
FANCA	ClinVar, OMIM, HUMSAVAR	HGNC link	16q24.3	1	PS227650
PALB2	ClinVar, OMIM	HGNC link	16p12.2	3	PS227650, 114480, 613348
ERCC4	ClinVar, OMIM, HUMSAVAR	HGNC link	16p13.12	3	278760, PS227650, 610965
FANCG	ClinVar, OMIM, HUMSAVAR	HGNC link	9p13.3	1	PS227650
FANCF	OMIM	HGNC link	11p14.3	1	PS227650
FANCE	ClinVar, OMIM	HGNC link	6p21.31	1	PS227650
FANCC	ClinVar, OMIM, HUMSAVAR	HGNC link	9q22.32	1	PS227650
FANCB	ClinVar, OMIM	HGNC link	Xp22.2	1	PS227650
FANCD2	ClinVar, OMIM, HUMSAVAR	HGNC link	3p25.3	1	PS227650
BRIP1	ClinVar, OMIM, HUMSAVAR	HGNC link	17q23.2	2	PS227650, 114480
FANCM	ClinVar	HGNC link	14q21.2	1	PS227650
FANCL	ClinVar, OMIM	HGNC link	2p16.1	1	PS227650
RAD51C	ClinVar, OMIM, HUMSAVAR	HGNC link	17q22	2	PS227650, PS604370
UBE2T	ClinVar, OMIM, HUMSAVAR	HGNC link	1q32.1	1	PS227650
FANCI	ClinVar, OMIM, HUMSAVAR	HGNC link	15q26.1	1	PS227650
SLX4	ClinVar, OMIM	HGNC link	16p13.3	1	PS227650

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
16p13	2	SLX4, ERCC4

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
17q2	3	BRCA1, RAD51C, BRIP1
16p1	3	PALB2, SLX4, ERCC4

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
16p	3	PALB2, SLX4, ERCC4
17q	3	BRCA1, RAD51C, BRIP1

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
17	3	BRCA1, RAD51C, BRIP1
16	4	FANCA, PALB2, SLX4, ERCC4
9	2	FANCC, FANCG

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
BRCA1	YES	52	ATM, RNASEL, DDIT3, KRT5, JAK2, MAD2L1, IRF7, EGFR, HSPA5, FOS, XPC, STAT2, EGR1, CCND1, AREG, FST, HNRNPA2B1, STAT1, CASR, E2F6, ESR1, SIRT1, DDB2, CDKN1A, KRT18, CXCL1, FOXC1, FOXC2, IFNA1, CDH3, CYP1A1, CTSD, IGF1, KHSRP, CYP19A1, HMGA2, EP300, KRT17, TFF1, STAT3, BRCA2, ASPM, TP63, IGF1R, GADD45A, JAK1, CDKN1B, CCNB1, MYC, VEGFA, IRF9, HIF1A	1	BRCA2
BRIP1	YES	1	BARD1	0
USF2	NO	42	PF4, FCER1A, CTSB, IGF2R, NR5A1, CEACAM1, MYH9, TRAP, ASPH, CEACAM5, TOP3A, PTGS2, PDX1, CYP19A1, HOXB4, THBS1, CFTR, TCN2, TGFB1, PKLR, FMR1, SLC19A1, APC, CD2, TGFB2, PIGR, CTSD, ASCL2, PTPN6, CXCR4, BRCA1, FBP1, BRCA2, CXCR2, ATP5A1, APOA2, APOA5, B2M, HMOX1, TERT, ABCA1, LIPC	2	BRCA1, BRCA2
TP53	NO	159	ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING1	2	BRCA1, BRCA2
E2F1	NO	123	WWOX, DOK1, MEFV, MYBL2, MCM8, FZD1, DIRAS3, PIN1, PCNA, DHFR, ETV4, LRBA, RPA2, FSHR, SERPINB5, PCSK6, TP53, FOXM1, E2F1, IL23A, CD2AP, HMGA1, XRCC1, FHIT, IRF3, ATM, MYC, MT1G, NRIP1, FLT1, RRP1B, MYB, SERPINE1, BMI1, CDKN2A, SKP2, MAPK8, CCNE1, CASP7, CDCA7, HIC1, THBS1, RB1, TNF, IL1B, ULK1, ERCC1, CUX1, TERT, MCL1, AR, KIR3DL1, NPAT, PDK4, DDB2, E2F6, ABCB1, BBC3, AURKA, NOX4, MYCN, CCNB1, TP73, FGFR1, RRM1, RRM2, HSPA5, TLR3, MUC4, CCND1, MCPH1, BRCA1, DRAM1, ERCC5, BIRC5, TYMS, RASGEF1B, MAP1LC3A, VEGFA, RACGAP1, FANCA, UHRF1, CHEK1, MCM5, RASGRP1, APAF1, ISYNA1, ECT2, TNFSF11, AURKB, CDK1, MDM2, DDIT3, MAP3K5, DBF4, PNRC2, KIF2C, POLA1, CTNNBIP1, ELF4, KDR, TP53INP1, ATAD2, CCL3, TK1, ATG5, CDKN1A, SIVA1, PEG10, TOP2A, CDAN1, CHEK2, DUSP1, ASF1B, DAPK2, PTPRO, BCL2, CREBBP, TP53BP2, GINS3, MYH10, PPARG, PPP1R13B	2	BRCA1, FANCA
CTBP1	NO	4	BRCA2, BRCA1, CLDN7, KRT18	2	BRCA1, BRCA2

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
BRCA1	YES	33	WWP1, RBL2, EZH2, DLX4, CTBP1, SP1, E2F4, ID4, NCOA3, USF2, MTA1, E2F1, FOSL2, RBL1, FOXP3, IFI16, NFE2L2, SP100, TP53, CTCF, EP300, ETS1, E2F6, NR3C1, YY1, JUN, TP53BP1, RB1, HMGA1, ESR1, AHR, CREBBP, FOXA1	0
BRCA2	YES	11	ESR2, CTBP1, HDAC1, ELF1, TP53, USF2, RELA, PARP1, BRCA1, NFKB1, USF1	1	BRCA1
FANCA	YES	1	E2F1	0
ERCC4	YES	1	FOS	0

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
BRCA1	BRCA2	Yes	29	ATM, BRE, FANCD2, SHFM1, H2AFX, CCNA2, SP1, ATR, BACH1, RPA1, STAT5A, SMAD3, BRCA1, RAD21, PALB2, MORF4L1, BARD1, PMS2, TP53, PCNA, SMC3, CHEK2, BRCC3, HNRNPC, CDK2, FLNA, PLK1, POLH, RAD51
BRCA1	FANCA	Yes	15	HSP90AA1, ATR, FANCA, CTNNB1, MSH2, DNAJB1, NPM1, BLM, RPA1, PCNA, CDK1, BRCA1, AKT1, SMARCA4, ENO1
BRCA1	PALB2	Yes	12	HNRNPC, BRCA2, BACH1, MORF4L1, USP2, MORF4L2, HIST1H2BG, POLH, RBBP8, BRCA1, PALB2, RAD51
BRCA1	ERCC4	No	6	FANCA, MSH2, PLK1, POLR2A, ERCC6, SUMO2
BRCA1	FANCG	No	10	CDK1, BRCA2, FANCD2, UIMC1, FANCA, RPA1, FAM175A, BLM, CTNNB1, BRCC3
BRCA1	FANCF	No	1	FANCA
BRCA1	FANCE	No	5	CHEK1, FANCA, BRCA2, FANCD2, PCNA
BRCA1	FANCC	No	9	FANCA, HSPA8, FANCD2, CDK1, HSP90AA1, DNAJB1, NPM1, CTNNB1, STAT1
BRCA1	FANCB	No	1	FANCA
BRCA1	FANCD2	Yes	23	ATM, HNRNPD, TERF1, MDC1, KAT5, ATR, FOXO3, MSH2, RBBP8, BRCA1, UBE2T, NBN, RAD18, REV1, PCNA, H2AFX, POLH, BRCA2, BLM, UBC, MYC, MLH1, RAD51
BRCA1	BRIP1	Yes	9	HNRNPC, TOPBP1, MLH1, BARD1, PMS2, RPA1, BLM, USP37, BRCA1
BRCA1	FANCM	No	6	FANCA, CDKN2AIP, RPA1, BLM, CLK2, UBE2I
BRCA1	FANCL	No	6	FANCA, FANCD2, PCNA, UBE2T, SSX2IP, UBE2W
BRCA1	RAD51C	No	1	RAD51
BRCA1	UBE2T	Yes	5	UBC, BRCA1, UBE2T, FANCD2, GNB2L1
BRCA1	FANCI	No	7	ATM, WDR48, VCP, FANCD2, RAD18, REV1, MYC
BRCA1	SLX4	No	17	MSH6, NBN, TOPBP1, VCP, SUMO1, TERF2, PGAM5, MRE11A, MSH3, RPA1, PLK1, PCNA, UBC, UBE2I, SUMO2, MSH2, DDB1
BRCA2	FANCA	No	6	ATR, RPA1, FANCE, PCNA, BRCA1, FANCG
BRCA2	PALB2	Yes	9	HNRNPC, BACH1, PALB2, USP11, PDS5B, POLH, BRCA1, MORF4L1, RAD51
BRCA2	ERCC4	No	2	FANCG, PLK1
BRCA2	FANCG	Yes	6	FANCD2, RPA1, FANCE, BRCC3, XRCC3, FANCG
BRCA2	FANCF	No	2	FANCE, FANCG
BRCA2	FANCE	Yes	3	FANCD2, FANCG, PCNA
BRCA2	FANCC	No	3	FANCE, FANCD2, FANCG
BRCA2	FANCB	No	1	FANCG
BRCA2	FANCD2	Yes	9	ATM, ATR, FANCE, RAD51, PCNA, BRCA1, POLH, H2AFX, FANCG
BRCA2	BRIP1	No	6	HNRNPC, BARD1, PMS2, RPA1, PMS1, BRCA1
BRCA2	FANCM	No	3	FANCE, RPA1, FANCG
BRCA2	FANCL	No	3	FANCD2, PCNA, FANCG
BRCA2	RAD51C	No	2	RAD51, XRCC3
BRCA2	UBE2T	No	2	BRCA1, FANCD2
BRCA2	FANCI	No	3	ATM, MAGED1, FANCD2
BRCA2	SLX4	No	3	RPA1, PCNA, PLK1
FANCA	PALB2	No	2	BRCA1, CAPN1
FANCA	ERCC4	Yes	5	FANCG, MSH2, FANCA, SPTAN1, SPTA1
FANCA	FANCG	Yes	23	C17ORF70, FANCC, SPTAN1, STRA13, FANCM, APITD1, POLN, TOP3A, RPA1, FANCF, CTNNB1, FANCL, CAPN1, C19ORF40, HES1, FANCB, C1ORF86, CDK1, FANCA, FANCE, ERCC4, BLM, FANCG
FANCA	FANCF	Yes	13	C17ORF70, FANCA, STRA13, FANCC, SPTAN1, HES1, FANCM, APITD1, FANCE, C1ORF86, RMI1, FANCL, FANCG
FANCA	FANCE	Yes	11	C17ORF70, FANCA, PCNA, STRA13, APITD1, FANCM, HES1, FANCF, C1ORF86, FANCC, FANCG
FANCA	FANCC	Yes	23	C17ORF70, SPTAN1, AZIN1, STRA13, FANCE, APITD1, HSP90B1, NPM1, DNAJB1, FANCF, CTNNB1, FANCL, CAPN1, KRT1, HES1, HSP90AA1, TCERG1, C1ORF86, CDK1, FANCA, FANCM, FANCG, RPL18
FANCA	FANCB	Yes	8	C17ORF70, FANCA, APITD1, FANCM, C19ORF40, C1ORF86, FANCL, FANCG
FANCA	FANCD2	No	11	ATR, FANCC, MSH2, BLM, FANCE, P2RY8, PCNA, BRCA1, FANCL, POLN, FANCG
FANCA	BRIP1	No	3	BRCA1, BLM, RPA1
FANCA	FANCM	Yes	18	C17ORF70, FANCA, STRA13, FANCC, FANCE, RPA1, RMI2, FANCM, BLM, FANCF, C19ORF40, C1ORF86, FANCB, TOP3A, FANCL, RMI1, FANCG, APITD1
FANCA	FANCL	Yes	14	C17ORF70, FANCA, C1ORF86, FANCL, STRA13, C19ORF40, FANCM, HES1, FANCF, APITD1, PCNA, FANCB, FANCC, FANCG
FANCA	RAD51C	No	1	BSG
FANCA	UBE2T	No	3	BRCA1, FANCL, RNF4
FANCA	FANCI	No	3	POLN, FANCL, C1ORF86
FANCA	SLX4	No	4	MSH2, ERCC4, RPA1, PCNA
PALB2	FANCG	No	2	CAPN1, BRCA2
PALB2	FANCE	No	1	BRCA2
PALB2	FANCC	No	1	CAPN1
PALB2	FANCD2	No	5	RBBP8, BRCA1, BRCA2, POLH, RAD51
PALB2	BRIP1	No	2	BRCA1, HNRNPC
PALB2	FANCM	No	1	MOV10
PALB2	RAD51C	No	1	RAD51
PALB2	UBE2T	No	1	BRCA1
PALB2	FANCI	No	2	CUL3, MOV10
ERCC4	FANCG	Yes	4	ERCC1, FANCA, SPTAN1, FANCG
ERCC4	FANCF	No	3	FANCA, SPTAN1, FANCG
ERCC4	FANCE	No	2	FANCA, FANCG
ERCC4	FANCC	No	3	FANCA, SPTAN1, FANCG
ERCC4	FANCB	No	2	FANCA, FANCG
ERCC4	FANCD2	No	3	NTRK1, MSH2, FANCG
ERCC4	FANCM	No	2	FANCA, FANCG
ERCC4	FANCL	No	2	FANCA, FANCG
ERCC4	FANCI	No	1	NTRK1
ERCC4	SLX4	Yes	10	ERCC1, SLX1A, MUS81, SLX1B, MSH2, PLK1, VPR, SLX4IP, SUMO2, USP45
FANCG	FANCF	Yes	12	C17ORF70, STRA13, FANCC, SPTAN1, HES1, FANCA, APITD1, FANCM, FANCE, C1ORF86, FANCL, FANCG
FANCG	FANCE	Yes	12	C17ORF70, BRCA2, FANCC, STRA13, FANCD2, FANCA, APITD1, FANCM, HES1, FANCF, C1ORF86, FANCG
FANCG	FANCC	Yes	16	CAPN1, FANCA, STRA13, CTNNB1, SPTAN1, FANCD2, HES1, C17ORF70, APITD1, FANCM, FANCE, FANCF, C1ORF86, CDK1, FANCL, FANCG
FANCG	FANCB	Yes	8	C17ORF70, FANCA, APITD1, FANCM, C19ORF40, C1ORF86, FANCL, FANCG
FANCG	FANCD2	Yes	8	BRCA2, FANCE, BLM, FAN1, FANCC, POLN, FANCL, FANCG
FANCG	BRIP1	No	2	BLM, RPA1
FANCG	FANCM	Yes	16	C17ORF70, FANCA, STRA13, FANCC, FANCE, RPA1, FANCM, BLM, FANCF, C19ORF40, C1ORF86, FANCB, TOP3A, FANCL, FANCG, APITD1
FANCG	FANCL	Yes	14	C17ORF70, STRA13, FANCC, FANCD2, FANCA, C19ORF40, FANCM, HES1, FANCF, APITD1, C1ORF86, FANCB, FANCL, FANCG
FANCG	RAD51C	No	1	XRCC3
FANCG	UBE2T	No	2	FANCD2, FANCL
FANCG	FANCI	No	5	POLN, FANCL, C1ORF86, FAN1, FANCD2
FANCG	SLX4	No	3	ERCC1, RPA1, ERCC4
FANCF	FANCE	Yes	9	C17ORF70, STRA13, FANCC, FANCA, APITD1, FANCM, HES1, C1ORF86, FANCG
FANCF	FANCC	Yes	11	C17ORF70, FANCA, SPTAN1, HES1, STRA13, APITD1, FANCM, FANCE, C1ORF86, FANCL, FANCG
FANCF	FANCB	No	7	C17ORF70, FANCA, APITD1, FANCM, C1ORF86, FANCL, FANCG
FANCF	FANCD2	No	4	FANCE, FANCL, FANCC, FANCG
FANCF	FANCM	Yes	11	C17ORF70, STRA13, C1ORF86, FANCA, APITD1, FANCM, FANCE, FANCC, RMI1, FANCL, FANCG
FANCF	FANCL	Yes	10	C17ORF70, STRA13, FANCC, FANCA, APITD1, FANCM, HES1, C1ORF86, FANCL, FANCG
FANCF	UBE2T	No	1	FANCL
FANCF	FANCI	No	2	FANCL, C1ORF86
FANCE	FANCC	Yes	10	C17ORF70, STRA13, FANCD2, FANCA, APITD1, FANCM, HES1, FANCF, C1ORF86, FANCG
FANCE	FANCB	No	7	C17ORF70, FANCC, FANCA, APITD1, FANCM, C1ORF86, FANCG
FANCE	FANCD2	Yes	5	FANCC, ELAVL1, BRCA2, FANCG, PCNA
FANCE	FANCM	Yes	9	STRA13, FANCA, FANCC, C17ORF70, APITD1, FANCM, FANCF, C1ORF86, FANCG
FANCE	FANCL	No	12	C17ORF70, STRA13, C1ORF86, FANCD2, FANCA, APITD1, FANCM, HES1, FANCF, PCNA, FANCC, FANCG
FANCE	UBE2T	No	1	FANCD2
FANCE	FANCI	No	2	FANCD2, C1ORF86
FANCE	SLX4	No	1	PCNA
FANCC	FANCB	No	7	C17ORF70, FANCA, APITD1, FANCM, C1ORF86, FANCL, FANCG
FANCC	FANCD2	Yes	3	FANCE, FANCL, FANCG
FANCC	FANCM	Yes	10	C17ORF70, FANCA, STRA13, APITD1, FANCM, FANCE, FANCF, C1ORF86, FANCL, FANCG
FANCC	FANCL	Yes	11	C17ORF70, STRA13, FANCD2, FANCA, APITD1, FANCM, HES1, FANCF, C1ORF86, FANCL, FANCG
FANCC	UBE2T	No	2	FANCD2, FANCL
FANCC	FANCI	No	3	FANCD2, FANCL, C1ORF86
FANCB	FANCD2	No	2	FANCL, FANCG
FANCB	FANCM	Yes	8	C17ORF70, FANCA, APITD1, FANCM, C19ORF40, C1ORF86, FANCL, FANCG
FANCB	FANCL	Yes	8	C17ORF70, FANCA, APITD1, FANCM, C19ORF40, C1ORF86, FANCL, FANCG
FANCB	RAD51C	No	1	THBS3
FANCB	UBE2T	No	1	FANCL
FANCB	FANCI	No	2	FANCL, C1ORF86
FANCD2	BRIP1	No	3	BRCA1, BLM, MLH1
FANCD2	FANCM	No	5	FANCC, BLM, FANCL, FANCE, FANCG
FANCD2	FANCL	Yes	6	FANCI, PCNA, UBE2T, FANCC, FANCL, FANCG
FANCD2	RAD51C	No	1	RAD51
FANCD2	UBE2T	Yes	4	UBC, UBE2T, BRCA1, FANCL
FANCD2	FANCI	Yes	9	ATM, CDC5L, RAD18, REV1, NTRK1, POLN, FANCL, MYC, FAN1
FANCD2	SLX4	No	6	NBN, MSH2, DCLRE1B, PCNA, UBC, KPNA1
BRIP1	FANCM	No	2	BLM, RPA1
BRIP1	UBE2T	No	1	BRCA1
BRIP1	FANCI	No	1	MMS19
BRIP1	SLX4	No	2	TOPBP1, RPA1
FANCM	FANCL	Yes	13	C17ORF70, FANCA, FANCC, KIFC3, STRA13, APITD1, FANCM, FANCF, C19ORF40, C1ORF86, FANCB, FANCL, FANCG
FANCM	RAD51C	No	1	APP
FANCM	UBE2T	No	2	FANCL, TRIM27
FANCM	FANCI	No	4	APP, FANCL, MOV10, C1ORF86
FANCM	SLX4	No	3	UBE2I, RPA1, APP
FANCL	UBE2T	Yes	3	UBE2T, FANCD2, FANCL
FANCL	FANCI	Yes	3	FANCD2, FANCL, C1ORF86
FANCL	SLX4	No	1	PCNA
RAD51C	FANCI	No	1	APP
RAD51C	SLX4	No	1	APP
UBE2T	FANCI	No	2	FANCD2, FANCL
UBE2T	SLX4	No	1	UBC
FANCI	SLX4	No	2	APP, VCP

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
BRCA1	BRCA2	Yes	binding	32	AR, TREX1, H2AFX, FANCD2, SHFM1, TEX15, HIST3H3, RPA3, RAD51B, ATR, MLH1, RAD51, RPA1, STAT5A, SMAD3, RPA2, PALB2, FANCI, DMC1, TP53, PSMC3IP, BRIP1, FANCA, CDK2, CDK4, BUB1B, PLK1, BLM, FANCG, MND1, CHEK2, RAD51C
BRCA1	FANCA	Yes	activation, binding	25	ATRIP, CDK1, PCNA, FANCD2, TOPBP1, FANCE, ATR, MSH2, RPA1, FANCF, RPA2, FANCL, CDKN1A, BARD1, FAH, HSP90AA1, AKT1, BRCA2, FANCI, UBE2T, BLM, SMARCA4, UBC, FANCC, FANCG
BRCA1	PALB2	Yes	binding	8	FANCI, BRCA2, MORF4L1, RBBP8, RAD51C, BRIP1, FANCD2, RAD51
BRCA1	ERCC4	No	-	16	MSH3, FANCA, RPA2, MSH2, ATR, RPA1, MNAT1, BLM, XRCC5, ERCC6, POLR2A, RPA3, MSH6, SUMO2, MLH1, FANCG
BRCA1	FANCG	Yes	activation, binding	18	ATRIP, FANCA, UBE2T, BRCA2, BLM, FANCL, FANCD2, BARD1, TOPBP1, RPA1, ATR, FANCI, FANCE, FANCF, RPA2, UBC, FAH, FANCC
BRCA1	FANCF	Yes	activation, binding	16	ATRIP, FANCA, FANCI, FANCC, UBE2T, FANCD2, BARD1, TOPBP1, RPA1, ATR, BLM, RPA2, UBC, FANCL, FANCG, FANCE
BRCA1	FANCE	Yes	activation, binding	16	ATRIP, TOPBP1, FANCI, FANCC, UBE2T, FANCD2, BARD1, FANCA, RPA1, ATR, BLM, FANCF, RPA2, UBC, FANCL, FANCG
BRCA1	FANCC	Yes	activation, binding	18	ATRIP, TOPBP1, HSPA8, UBE2T, FANCD2, BARD1, FANCA, RPA1, ATR, FANCI, BLM, FANCF, RPA2, CDK1, UBC, FANCL, FANCG, FANCE
BRCA1	FANCB	No	-	16	ATRIP, TOPBP1, FANCI, FANCC, UBE2T, FANCD2, FANCE, FANCA, RPA1, ATR, BLM, FANCF, RPA2, UBC, FANCL, FANCG
BRCA1	FANCD2	Yes	activation, binding	28	ATRIP, FANCC, PALB2, FANCI, FANCE, RAD50, UBE2W, ATR, MSH2, RPA1, RBBP8, RPA2, FANCF, FANCL, TOPBP1, RAD18, BARD1, PCNA, BRCA2, H2AFX, FANCA, CLSPN, UBE2T, BLM, UBC, POLH, MLH1, FANCG
BRCA1	BRIP1	Yes	binding	8	TOPBP1, BRCA2, PALB2, RPA1, BLM, PLK1, UBC, MLH1
BRCA1	FANCM	No	-	17	ATRIP, MSH3, FANCI, UBE2T, MSH2, FANCE, FANCA, RPA1, ATR, BLM, FANCF, FANCC, UBC, MSH6, FANCL, FANCD2, FANCG
BRCA1	FANCL	Yes	activation, binding	18	ATRIP, TOPBP1, FANCI, RPA2, UBE2T, FANCD2, BARD1, FANCA, RPA1, ATR, BLM, FANCF, UBE2W, PCNA, UBC, FANCC, FANCG, FANCE
BRCA1	RAD51C	Yes	activation, binding	15	ACACA, BRCA2, RPA2, RAD51B, PALB2, RPA1, PSMC3IP, DMC1, CDK4, MND1, RPA3, HIST3H3, H2AFX, MLH1, RAD51
BRCA1	UBE2T	Yes	binding	16	ATRIP, TOPBP1, FANCI, FANCC, FANCL, FANCD2, FANCE, FANCA, RPA1, ATR, BLM, FANCF, RPA2, UBC, SUMO2, FANCG
BRCA1	FANCI	Yes	activation, binding	17	ATRIP, TOPBP1, BRCA2, FANCC, UBE2T, PALB2, FANCA, RPA1, ATR, FANCE, FANCF, RPA2, UBC, H2AFX, FANCL, FANCD2, FANCG
BRCA1	SLX4	No	-	4	UBC, TERF2, MSH2, PLK1
BRCA2	FANCA	Yes	binding	10	ATR, FANCD2, CHEK1, FANCI, RPA1, BLM, RPA2, BRCA1, TOP3A, FANCG
BRCA2	PALB2	Yes	binding	6	FANCI, FANCD2, RAD51, BRCA1, BRIP1, RAD51C
BRCA2	ERCC4	No	-	10	ATR, MLH1, FANCA, RPA1, BLM, MLH3, RPA2, RPA3, TOP3A, FANCG
BRCA2	FANCG	Yes	binding	11	ATR, FANCI, XRCC3, FANCD2, CHEK1, FANCA, RPA1, BLM, RPA2, BRCA1, TOP3A
BRCA2	FANCF	No	-	11	FANCA, FANCI, FANCD2, CHEK1, ATR, RPA1, BLM, RPA2, BRCA1, TOP3A, FANCG
BRCA2	FANCE	No	-	11	ATR, FANCI, FANCD2, CHEK1, FANCA, RPA1, BLM, RPA2, BRCA1, TOP3A, FANCG
BRCA2	FANCC	No	-	11	ATR, FANCI, FANCD2, CHEK1, FANCA, RPA1, BLM, RPA2, BRCA1, TOP3A, FANCG
BRCA2	FANCB	No	-	10	ATR, FANCI, FANCD2, CHEK1, FANCA, RPA1, BLM, RPA2, TOP3A, FANCG
BRCA2	FANCD2	Yes	activation, binding	13	ATR, FANCI, XRCC3, PALB2, CHEK1, FANCA, RPA1, BLM, RPA2, BRCA1, H2AFX, FANCG, MLH1
BRCA2	BRIP1	Yes	binding	7	PALB2, RPA1, BLM, PLK1, BRCA1, TOP3A, MLH1
BRCA2	FANCM	No	-	8	FANCA, FANCI, FANCD2, ATR, RPA1, BLM, TOP3A, FANCG
BRCA2	FANCL	No	-	11	ATR, FANCI, FANCD2, CHEK1, FANCA, RPA1, BLM, RPA2, BRCA1, TOP3A, FANCG
BRCA2	RAD51C	Yes	activation, binding	17	XRCC3, HIST3H3, RPA2, RAD51D, H2AFX, PALB2, RAD51, RPA1, RAD51B, PSMC3IP, DMC1, CDK4, MND1, RPA3, BRCA1, MLH1, MLH3
BRCA2	UBE2T	No	-	11	ATR, FANCI, FANCD2, CHEK1, FANCA, RPA1, BLM, RPA2, BRCA1, TOP3A, FANCG
BRCA2	FANCI	Yes	binding	9	FANCA, PALB2, ATR, RPA1, RPA2, BRCA1, H2AFX, FANCG, FANCD2
BRCA2	SLX4	No	-	1	PLK1
FANCA	PALB2	No	-	4	BRCA1, BRCA2, FANCD2, FANCI
FANCA	ERCC4	Yes	binding	12	ATR, RAD1, SPTAN1, FEN1, MSH2, FANCM, RPA1, BLM, C19ORF40, RPA2, TOP3A, FANCG
FANCA	FANCG	Yes	binding	43	ATRIP, C17ORF70, FANCC, SPTAN1, FANCD2, RPA1, TOPBP1, STRA13, FANCM, APITD1, RMI1, TOP3A, UBB, RPS27A, RAD9A, RAD17, BLM, RFC5, FANCF, RPA2, BRCA1, FANCL, UBA52, FANCI, PRDX3, CYP2E1, RAD1, RFC3, BARD1, ATR, C19ORF40, HES1, FANCB, C1ORF86, FAH, BRCA2, UBE2T, CHEK1, FANCE, ERCC4, HUS1, RFC4, UBC
FANCA	FANCF	Yes	binding	37	ATRIP, C17ORF70, FANCC, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCE, APITD1, RMI1, TOP3A, UBB, RPS27A, RAD17, BLM, RFC5, RPA2, BRCA1, FANCL, UBA52, FANCI, RAD1, RFC3, BARD1, ATR, C19ORF40, HES1, FANCB, C1ORF86, UBE2T, CHEK1, FANCM, HUS1, RFC4, UBC, FANCG
FANCA	FANCE	Yes	binding	37	ATRIP, C17ORF70, FANCC, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCM, APITD1, RMI1, TOP3A, UBB, RPS27A, RAD17, BLM, RFC5, FANCF, RPA2, BRCA1, FANCL, UBA52, FANCI, RAD1, RFC3, BARD1, ATR, C19ORF40, HES1, FANCB, C1ORF86, UBE2T, CHEK1, HUS1, RFC4, UBC, FANCG
FANCA	FANCC	Yes	binding	43	ATRIP, C17ORF70, C1ORF86, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCE, APITD1, RMI1, TOP3A, SNX5, RPS27A, SPTAN1, RAD17, BLM, RFC5, FANCF, RPA2, BRCA1, FANCL, UBA52, FANCI, CYP2E1, RAD1, RFC3, BARD1, ATR, C19ORF40, HES1, FANCB, PRDX3, GSTP1, CDK1, UBB, UBE2T, CHEK1, FANCM, HUS1, RFC4, UBC, FANCG
FANCA	FANCB	Yes	binding	35	ATRIP, C17ORF70, FANCC, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCE, APITD1, RMI1, TOP3A, UBB, RPS27A, RAD17, BLM, RFC5, FANCF, RPA2, FANCL, UBA52, FANCI, RAD1, RFC3, ATR, C19ORF40, HES1, C1ORF86, UBE2T, CHEK1, FANCM, HUS1, RFC4, UBC, FANCG
FANCA	FANCD2	Yes	activation, binding	38	ATRIP, C17ORF70, FANCC, RAD9A, RPA1, TOPBP1, STRA13, FANCE, APITD1, UBB, PCNA, RPS27A, RAD17, BLM, RFC5, FANCF, RPA2, BRCA1, FANCL, UBA52, FANCI, RAD1, RFC3, BARD1, ATR, C19ORF40, HES1, FANCB, C1ORF86, BRCA2, UBE2T, CHEK1, FANCM, HUS1, RFC4, UBC, MSH2, FANCG
FANCA	BRIP1	No	-	8	TOPBP1, BRCA2, RPA1, RMI1, BLM, UBC, BRCA1, TOP3A
FANCA	FANCM	Yes	activation, binding	30	ATRIP, C17ORF70, FANCC, FANCD2, STRA13, FANCE, APITD1, RMI1, TOP3A, UBB, RPS27A, FEN1, MSH2, RPA1, FANCF, FANCL, FANCI, RAD1, UBA52, ATR, C19ORF40, HES1, FANCB, C1ORF86, MUS81, UBE2T, ERCC4, BLM, UBC, FANCG
FANCA	FANCL	Yes	binding	38	ATRIP, C17ORF70, FANCC, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCE, APITD1, RMI1, TOP3A, PCNA, UBB, RPS27A, RAD17, BLM, RFC5, FANCF, RPA2, BRCA1, UBE2T, UBA52, FANCI, RAD1, RFC3, BARD1, ATR, C19ORF40, HES1, FANCB, C1ORF86, CHEK1, FANCM, HUS1, RFC4, UBC, FANCG
FANCA	RAD51C	No	-	4	BRCA1, BRCA2, RPA2, RPA1
FANCA	UBE2T	Yes	binding	32	ATRIP, C17ORF70, RAD9A, FANCD2, TOPBP1, FANCE, RPA1, RMI1, TOP3A, ATR, RAD17, BLM, RFC5, FANCF, RPA2, BRCA1, FANCL, APITD1, FANCI, STRA13, RAD1, RFC3, C19ORF40, HES1, FANCB, FANCC, CHEK1, FANCM, HUS1, RFC4, UBC, FANCG
FANCA	FANCI	Yes	activation, binding	32	ATRIP, C17ORF70, RAD9A, FANCD2, RPA1, TOPBP1, FANCE, APITD1, UBB, RPS27A, RAD17, RFC5, FANCF, RPA2, BRCA1, FANCL, UBA52, STRA13, RAD1, RFC3, ATR, C19ORF40, HES1, FANCB, FANCC, BRCA2, UBE2T, FANCM, HUS1, RFC4, UBC, FANCG
FANCA	SLX4	No	-	4	MUS81, UBC, MSH2, ERCC4
PALB2	FANCG	No	-	4	BRCA1, BRCA2, FANCD2, FANCI
PALB2	FANCF	No	-	3	BRCA1, FANCI, FANCD2
PALB2	FANCE	No	-	3	BRCA1, FANCI, FANCD2
PALB2	FANCC	No	-	3	BRCA1, FANCI, FANCD2
PALB2	FANCB	No	-	2	FANCD2, FANCI
PALB2	FANCD2	Yes	binding	4	RBBP8, BRCA1, BRCA2, FANCI
PALB2	BRIP1	Yes	binding	2	BRCA1, BRCA2
PALB2	FANCM	No	-	2	FANCD2, FANCI
PALB2	FANCL	No	-	3	BRCA1, FANCI, FANCD2
PALB2	RAD51C	Yes	activation, binding	3	BRCA1, BRCA2, RAD51
PALB2	UBE2T	No	-	3	BRCA1, FANCI, FANCD2
PALB2	FANCI	Yes	binding	3	BRCA1, BRCA2, FANCD2
ERCC4	FANCG	Yes	binding	11	ERCC1, FANCA, SPTAN1, RAD1, ATR, RPA1, FANCM, BLM, C19ORF40, RPA2, TOP3A
ERCC4	FANCF	No	-	10	FANCA, RAD1, ATR, RPA1, FANCM, BLM, C19ORF40, RPA2, TOP3A, FANCG
ERCC4	FANCE	No	-	10	ATR, RAD1, FANCA, RPA1, FANCM, BLM, C19ORF40, RPA2, TOP3A, FANCG
ERCC4	FANCC	No	-	11	ATR, RAD1, SPTAN1, FANCA, RPA1, FANCM, BLM, C19ORF40, RPA2, TOP3A, FANCG
ERCC4	FANCB	No	-	10	ATR, RAD1, FANCA, RPA1, FANCM, BLM, C19ORF40, RPA2, TOP3A, FANCG
ERCC4	FANCD2	No	-	11	ATR, RAD1, MSH2, FANCA, RPA1, FANCM, BLM, C19ORF40, RPA2, MLH1, FANCG
ERCC4	BRIP1	No	-	7	POLD1, PMS2, ERCC2, MLH1, RPA1, BLM, TOP3A
ERCC4	FANCM	Yes	binding	26	ERCC5, TOP3A, XPA, POLD1, ATR, POLE, MSH2, RPA1, RECQL, REV3L, ERCC1, GEN1, RAD1, FANCA, C19ORF40, TOP3B, EXO1, MSH6, UBE2B, MSH3, FEN1, WRN, XRCC6, BLM, UBE2A, FANCG
ERCC4	FANCL	No	-	10	ATR, RAD1, FANCA, RPA1, FANCM, BLM, C19ORF40, RPA2, TOP3A, FANCG
ERCC4	RAD51C	No	-	5	RPA3, MLH1, RPA1, MLH3, RPA2
ERCC4	UBE2T	No	-	11	ATR, RAD1, FANCA, RPA1, FANCM, BLM, C19ORF40, RPA2, TOP3A, SUMO2, FANCG
ERCC4	FANCI	No	-	8	FANCA, RAD1, ATR, RPA1, FANCM, C19ORF40, RPA2, FANCG
ERCC4	SLX4	Yes	binding	4	ERCC1, MSH2, DDB1, SLX1A
FANCG	FANCF	Yes	binding	37	ATRIP, C17ORF70, FANCC, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCE, APITD1, RMI1, TOP3A, UBB, RPS27A, RAD17, BLM, RFC5, RPA2, BRCA1, FANCL, UBA52, FANCI, RAD1, RFC3, BARD1, ATR, C19ORF40, HES1, FANCB, C1ORF86, FANCA, UBE2T, CHEK1, FANCM, HUS1, RFC4, UBC
FANCG	FANCE	Yes	binding	37	ATRIP, C17ORF70, FANCC, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCM, APITD1, RMI1, TOP3A, UBB, RPS27A, RAD17, BLM, RFC5, FANCF, RPA2, BRCA1, FANCL, UBA52, FANCI, RAD1, RFC3, BARD1, ATR, C19ORF40, HES1, FANCB, C1ORF86, FANCA, UBE2T, CHEK1, HUS1, RFC4, UBC
FANCG	FANCC	Yes	binding	40	ATRIP, C17ORF70, PRDX3, SPTAN1, FANCD2, RPA1, TOPBP1, STRA13, FANCE, APITD1, RMI1, TOP3A, UBB, RPS27A, RAD9A, RAD17, BLM, RFC5, FANCF, RPA2, BRCA1, FANCL, UBA52, FANCI, CYP2E1, RAD1, RFC3, BARD1, ATR, C19ORF40, HES1, FANCB, C1ORF86, FANCA, UBE2T, CHEK1, FANCM, HUS1, RFC4, UBC
FANCG	FANCB	Yes	binding	35	ATRIP, C17ORF70, FANCC, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCE, APITD1, RMI1, TOP3A, UBB, RPS27A, RAD17, BLM, RFC5, FANCF, RPA2, FANCL, UBA52, FANCI, RAD1, RFC3, ATR, C19ORF40, HES1, C1ORF86, FANCA, UBE2T, CHEK1, FANCM, HUS1, RFC4, UBC
FANCG	FANCD2	Yes	activation, binding	37	ATRIP, C17ORF70, FANCC, RAD9A, RPA1, TOPBP1, STRA13, FANCE, APITD1, XRCC3, UBB, RPS27A, RAD17, BLM, RFC5, FANCF, RPA2, BRCA1, FANCL, UBA52, FANCI, RAD1, RFC3, BARD1, ATR, C19ORF40, HES1, FANCB, C1ORF86, FANCA, BRCA2, UBE2T, CHEK1, FANCM, HUS1, RFC4, UBC
FANCG	BRIP1	No	-	8	TOPBP1, BRCA2, RPA1, RMI1, BLM, UBC, BRCA1, TOP3A
FANCG	FANCM	Yes	activation, binding	28	ATRIP, C17ORF70, C1ORF86, FANCD2, STRA13, FANCE, APITD1, RMI1, TOP3A, UBB, RPS27A, RPA1, FANCF, FANCL, ERCC1, FANCI, RAD1, UBA52, ATR, C19ORF40, HES1, FANCB, FANCC, FANCA, UBE2T, ERCC4, BLM, UBC
FANCG	FANCL	Yes	binding	37	ATRIP, C17ORF70, FANCC, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCE, APITD1, RMI1, TOP3A, UBB, RPS27A, RAD17, BLM, RFC5, FANCF, RPA2, BRCA1, UBE2T, UBA52, FANCI, RAD1, RFC3, BARD1, ATR, C19ORF40, HES1, FANCB, C1ORF86, FANCA, CHEK1, FANCM, HUS1, RFC4, UBC
FANCG	RAD51C	No	-	5	BRCA1, BRCA2, RPA1, XRCC3, RPA2
FANCG	UBE2T	Yes	binding	32	ATRIP, C17ORF70, RAD9A, FANCD2, TOPBP1, FANCE, RPA1, RMI1, TOP3A, ATR, RAD17, BLM, RFC5, FANCF, RPA2, BRCA1, FANCL, APITD1, FANCI, STRA13, RAD1, RFC3, C19ORF40, HES1, FANCB, FANCC, FANCA, CHEK1, FANCM, HUS1, RFC4, UBC
FANCG	FANCI	Yes	activation, binding	32	ATRIP, C17ORF70, RAD9A, FANCD2, RPA1, TOPBP1, FANCE, APITD1, UBB, RPS27A, RAD17, RFC5, FANCF, RPA2, BRCA1, FANCL, UBA52, STRA13, RAD1, RFC3, ATR, C19ORF40, HES1, FANCB, FANCC, FANCA, BRCA2, UBE2T, FANCM, HUS1, RFC4, UBC
FANCG	SLX4	No	-	3	ERCC1, UBC, ERCC4
FANCF	FANCE	Yes	binding	37	ATRIP, C17ORF70, FANCC, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCM, APITD1, RMI1, TOP3A, UBB, RPS27A, RAD17, BLM, RFC5, RPA2, BRCA1, FANCL, UBA52, FANCI, RAD1, RFC3, BARD1, ATR, C19ORF40, HES1, FANCB, C1ORF86, FANCA, UBE2T, CHEK1, HUS1, RFC4, UBC, FANCG
FANCF	FANCC	Yes	binding	37	ATRIP, C17ORF70, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCE, APITD1, RMI1, TOP3A, UBB, RPS27A, RAD17, BLM, RFC5, RPA2, BRCA1, FANCL, UBA52, FANCI, RAD1, RFC3, BARD1, ATR, C19ORF40, HES1, FANCB, C1ORF86, FANCA, UBE2T, CHEK1, FANCM, HUS1, RFC4, UBC, FANCG
FANCF	FANCB	Yes	binding	35	ATRIP, C17ORF70, FANCC, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCE, APITD1, RMI1, TOP3A, UBB, RPS27A, RAD17, BLM, RFC5, RPA2, FANCL, UBA52, FANCI, RAD1, RFC3, ATR, C19ORF40, HES1, C1ORF86, FANCA, UBE2T, CHEK1, FANCM, HUS1, RFC4, UBC, FANCG
FANCF	FANCD2	Yes	activation, binding	35	ATRIP, C17ORF70, FANCC, RAD9A, RPA1, TOPBP1, STRA13, FANCE, APITD1, UBB, RPS27A, RAD17, BLM, RFC5, RPA2, BRCA1, FANCL, UBA52, FANCI, RAD1, RFC3, BARD1, ATR, C19ORF40, HES1, FANCB, C1ORF86, FANCA, UBE2T, CHEK1, FANCM, HUS1, RFC4, UBC, FANCG
FANCF	BRIP1	No	-	7	TOPBP1, RPA1, RMI1, BLM, UBC, BRCA1, TOP3A
FANCF	FANCM	Yes	activation, binding	26	ATRIP, C17ORF70, C1ORF86, FANCD2, STRA13, FANCE, RPA1, UBB, TOP3A, RMI1, ATR, APITD1, FANCL, FANCI, RAD1, UBA52, RPS27A, C19ORF40, HES1, FANCB, FANCC, FANCA, UBE2T, BLM, UBC, FANCG
FANCF	FANCL	Yes	binding	37	ATRIP, C17ORF70, FANCC, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCE, APITD1, RMI1, TOP3A, UBB, RPS27A, RAD17, BLM, RFC5, RPA2, BRCA1, UBE2T, UBA52, FANCI, RAD1, RFC3, BARD1, ATR, C19ORF40, HES1, FANCB, C1ORF86, FANCA, CHEK1, FANCM, HUS1, RFC4, UBC, FANCG
FANCF	RAD51C	No	-	3	BRCA1, RPA2, RPA1
FANCF	UBE2T	Yes	binding	32	ATRIP, C17ORF70, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCE, APITD1, RMI1, TOP3A, ATR, RAD17, BLM, RFC5, RPA2, BRCA1, FANCL, FANCI, RAD1, RFC3, C19ORF40, HES1, FANCB, FANCC, FANCA, CHEK1, FANCM, HUS1, RFC4, UBC, FANCG
FANCF	FANCI	Yes	activation, binding	31	ATRIP, C17ORF70, RAD9A, FANCD2, RPA1, TOPBP1, FANCE, APITD1, UBB, RPS27A, RAD17, RFC5, RPA2, BRCA1, FANCL, UBA52, STRA13, RAD1, RFC3, ATR, C19ORF40, HES1, FANCB, FANCC, FANCA, UBE2T, FANCM, HUS1, RFC4, UBC, FANCG
FANCF	SLX4	No	-	1	UBC
FANCE	FANCC	Yes	binding	37	ATRIP, C17ORF70, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCM, APITD1, RMI1, TOP3A, UBB, RPS27A, RAD17, BLM, RFC5, FANCF, RPA2, BRCA1, FANCL, UBA52, FANCI, RAD1, RFC3, BARD1, ATR, C19ORF40, HES1, FANCB, C1ORF86, FANCA, UBE2T, CHEK1, HUS1, RFC4, UBC, FANCG
FANCE	FANCB	Yes	binding	35	ATRIP, C17ORF70, FANCC, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCM, APITD1, RMI1, TOP3A, UBB, RPS27A, RAD17, BLM, RFC5, FANCF, RPA2, FANCL, UBA52, FANCI, RAD1, RFC3, ATR, C19ORF40, HES1, C1ORF86, FANCA, UBE2T, CHEK1, HUS1, RFC4, UBC, FANCG
FANCE	FANCD2	Yes	activation, binding	35	ATRIP, C17ORF70, FANCC, RAD9A, RPA1, TOPBP1, STRA13, FANCM, APITD1, UBB, RPS27A, RAD17, BLM, RFC5, FANCF, RPA2, BRCA1, FANCL, UBA52, FANCI, RAD1, RFC3, BARD1, ATR, C19ORF40, HES1, FANCB, C1ORF86, FANCA, UBE2T, CHEK1, HUS1, RFC4, UBC, FANCG
FANCE	BRIP1	No	-	7	TOPBP1, RPA1, RMI1, BLM, UBC, BRCA1, TOP3A
FANCE	FANCM	Yes	activation, binding	26	ATRIP, C17ORF70, C1ORF86, FANCD2, STRA13, TOP3A, RPA1, UBB, RMI1, ATR, APITD1, FANCF, FANCL, FANCI, RAD1, UBA52, RPS27A, C19ORF40, HES1, FANCB, FANCC, FANCA, UBE2T, BLM, UBC, FANCG
FANCE	FANCL	Yes	binding	37	ATRIP, C17ORF70, FANCC, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCM, APITD1, RMI1, TOP3A, UBB, RPS27A, RAD17, BLM, RFC5, FANCF, RPA2, BRCA1, UBE2T, UBA52, FANCI, RAD1, RFC3, BARD1, ATR, C19ORF40, HES1, FANCB, C1ORF86, FANCA, CHEK1, HUS1, RFC4, UBC, FANCG
FANCE	RAD51C	No	-	3	BRCA1, RPA2, RPA1
FANCE	UBE2T	Yes	binding	32	ATRIP, C17ORF70, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCM, APITD1, RMI1, TOP3A, ATR, RAD17, BLM, RFC5, FANCF, RPA2, BRCA1, FANCL, FANCI, RAD1, RFC3, C19ORF40, HES1, FANCB, FANCC, FANCA, CHEK1, HUS1, RFC4, UBC, FANCG
FANCE	FANCI	Yes	activation, binding	31	ATRIP, C17ORF70, RAD9A, FANCD2, RPA1, TOPBP1, FANCM, APITD1, UBB, RPS27A, RAD17, RFC5, FANCF, RPA2, BRCA1, FANCL, UBA52, STRA13, RAD1, RFC3, ATR, C19ORF40, HES1, FANCB, FANCC, FANCA, UBE2T, HUS1, RFC4, UBC, FANCG
FANCE	SLX4	No	-	1	UBC
FANCC	FANCB	Yes	binding	35	ATRIP, C17ORF70, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCE, APITD1, RMI1, TOP3A, UBB, RPS27A, RAD17, BLM, RFC5, FANCF, RPA2, FANCL, UBA52, FANCI, RAD1, RFC3, ATR, C19ORF40, HES1, C1ORF86, FANCA, UBE2T, CHEK1, FANCM, HUS1, RFC4, UBC, FANCG
FANCC	FANCD2	Yes	activation, binding	36	ATRIP, C17ORF70, RAD9A, RPA1, TOPBP1, STRA13, FANCE, APITD1, UBB, RPS27A, RAD17, BLM, RFC5, ZBTB32, FANCF, RPA2, BRCA1, FANCL, UBA52, FANCI, RAD1, RFC3, BARD1, ATR, C19ORF40, HES1, FANCB, C1ORF86, FANCA, UBE2T, CHEK1, FANCM, HUS1, RFC4, UBC, FANCG
FANCC	BRIP1	No	-	7	TOPBP1, RPA1, RMI1, BLM, UBC, BRCA1, TOP3A
FANCC	FANCM	Yes	activation, binding	26	ATRIP, C17ORF70, FANCD2, STRA13, FANCE, RPA1, UBB, TOP3A, RMI1, ATR, APITD1, FANCF, FANCL, FANCI, RAD1, UBA52, RPS27A, C19ORF40, HES1, FANCB, C1ORF86, FANCA, UBE2T, BLM, UBC, FANCG
FANCC	FANCL	Yes	binding	37	ATRIP, C17ORF70, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCE, APITD1, RMI1, TOP3A, UBB, RPS27A, RAD17, BLM, RFC5, FANCF, RPA2, BRCA1, UBE2T, UBA52, FANCI, RAD1, RFC3, BARD1, ATR, C19ORF40, HES1, FANCB, C1ORF86, FANCA, CHEK1, FANCM, HUS1, RFC4, UBC, FANCG
FANCC	RAD51C	No	-	3	BRCA1, RPA2, RPA1
FANCC	UBE2T	Yes	binding	32	ATRIP, C17ORF70, RAD9A, FANCD2, TOPBP1, FANCE, RPA1, RMI1, TOP3A, ATR, RAD17, BLM, RFC5, FANCF, RPA2, BRCA1, FANCL, APITD1, FANCI, STRA13, RAD1, RFC3, C19ORF40, HES1, FANCB, FANCA, CHEK1, FANCM, HUS1, RFC4, UBC, FANCG
FANCC	FANCI	Yes	activation, binding	32	ATRIP, C17ORF70, RAD9A, FANCD2, TOPBP1, FANCE, RPA1, UBB, RPS27A, RAD17, RFC5, ZBTB32, FANCF, RPA2, BRCA1, FANCL, UBA52, APITD1, STRA13, RAD1, RFC3, ATR, C19ORF40, HES1, FANCB, FANCA, UBE2T, FANCM, HUS1, RFC4, UBC, FANCG
FANCC	SLX4	No	-	1	UBC
FANCB	FANCD2	Yes	activation, binding	33	ATRIP, C17ORF70, FANCC, RAD9A, RPA1, TOPBP1, STRA13, FANCE, APITD1, UBB, RPS27A, RAD17, BLM, RFC5, FANCF, RPA2, FANCL, UBA52, FANCI, RAD1, RFC3, ATR, C19ORF40, HES1, C1ORF86, FANCA, UBE2T, CHEK1, FANCM, HUS1, RFC4, UBC, FANCG
FANCB	BRIP1	No	-	6	TOPBP1, RPA1, BLM, UBC, TOP3A, RMI1
FANCB	FANCM	Yes	activation, binding	26	ATRIP, C17ORF70, C1ORF86, FANCD2, STRA13, FANCE, RPA1, UBB, TOP3A, RMI1, ATR, APITD1, FANCF, FANCL, FANCI, RAD1, UBA52, RPS27A, C19ORF40, HES1, FANCC, FANCA, UBE2T, BLM, UBC, FANCG
FANCB	FANCL	Yes	binding	35	ATRIP, C17ORF70, FANCC, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCE, APITD1, RMI1, TOP3A, UBB, RPS27A, RAD17, BLM, RFC5, FANCF, RPA2, UBE2T, UBA52, FANCI, RAD1, RFC3, ATR, C19ORF40, HES1, C1ORF86, FANCA, CHEK1, FANCM, HUS1, RFC4, UBC, FANCG
FANCB	RAD51C	No	-	2	RPA2, RPA1
FANCB	UBE2T	Yes	binding	31	ATRIP, C17ORF70, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCE, APITD1, RMI1, TOP3A, ATR, RAD17, BLM, RFC5, FANCF, RPA2, FANCL, FANCI, RAD1, RFC3, C19ORF40, HES1, FANCC, FANCA, CHEK1, FANCM, HUS1, RFC4, UBC, FANCG
FANCB	FANCI	Yes	activation, binding	30	ATRIP, C17ORF70, RAD9A, FANCD2, RPA1, TOPBP1, FANCE, APITD1, UBB, RPS27A, RAD17, RFC5, FANCF, RPA2, FANCL, UBA52, STRA13, RAD1, RFC3, ATR, C19ORF40, HES1, FANCC, FANCA, UBE2T, FANCM, HUS1, RFC4, UBC, FANCG
FANCB	SLX4	No	-	1	UBC
FANCD2	BRIP1	No	-	8	TOPBP1, BRCA2, PALB2, RPA1, BLM, UBC, BRCA1, MLH1
FANCD2	FANCM	Yes	activation, binding	25	ATRIP, C17ORF70, C1ORF86, STRA13, FANCE, RPA1, UBB, ATR, MSH2, APITD1, FANCF, FANCL, FANCI, RAD1, UBA52, RPS27A, C19ORF40, HES1, FANCB, FANCC, FANCA, UBE2T, BLM, UBC, FANCG
FANCD2	FANCL	Yes	activation, binding	39	ATRIP, C17ORF70, FANCC, RAD9A, RPA1, TOPBP1, STRA13, FANCE, APITD1, UBB, PCNA, UBE2W, RPS27A, RAD17, BLM, RFC5, FANCF, RPA2, BRCA1, UBE2T, UBA52, FANCI, RAD1, RFC3, BARD1, ATR, C19ORF40, FANCM, HES1, FANCB, C1ORF86, FANCA, CHEK1, WDR48, HUS1, USP1, RFC4, UBC, FANCG
FANCD2	RAD51C	No	-	9	BRCA2, XRCC3, PALB2, RPA1, RPA2, BRCA1, H2AFX, HELQ, MLH1
FANCD2	UBE2T	Yes	activation, binding	30	ATRIP, C17ORF70, RAD9A, TOPBP1, FANCE, RPA1, ATR, RAD17, BLM, RFC5, FANCF, RPA2, BRCA1, FANCL, APITD1, FANCI, STRA13, RAD1, RFC3, C19ORF40, HES1, FANCB, FANCC, FANCA, CHEK1, FANCM, HUS1, RFC4, UBC, FANCG
FANCD2	FANCI	Yes	activation, binding	40	ATRIP, C17ORF70, RAD9A, PALB2, RPA1, TOPBP1, FANCE, APITD1, POLN, UBB, HELQ, RPS27A, RAD17, RFC5, ZBTB32, FANCF, RPA2, BRCA1, FANCL, UBA52, STRA13, RAD1, RFC3, ATR, C19ORF40, FANCM, HES1, FANCB, FANCC, H2AFX, FAN1, FANCA, BRCA2, UBE2T, WDR48, HUS1, USP1, RFC4, UBC, FANCG
FANCD2	SLX4	No	-	3	UBC, MSH2, DCLRE1B
BRIP1	FANCM	No	-	6	POLD1, RPA1, BLM, UBC, RMI1, TOP3A
BRIP1	FANCL	No	-	7	TOPBP1, RPA1, RMI1, BLM, UBC, BRCA1, TOP3A
BRIP1	RAD51C	No	-	5	BRCA1, BRCA2, PALB2, RPA1, MLH1
BRIP1	UBE2T	No	-	7	TOPBP1, RPA1, RMI1, BLM, UBC, BRCA1, TOP3A
BRIP1	FANCI	No	-	6	TOPBP1, BRCA2, PALB2, RPA1, UBC, BRCA1
BRIP1	SLX4	No	-	2	UBC, PLK1
FANCM	FANCL	Yes	activation, binding	26	ATRIP, C17ORF70, C1ORF86, FANCD2, STRA13, FANCE, RPA1, UBB, TOP3A, RMI1, ATR, APITD1, FANCF, UBE2T, FANCI, RAD1, UBA52, RPS27A, C19ORF40, HES1, FANCB, FANCC, FANCA, BLM, UBC, FANCG
FANCM	RAD51C	No	-	3	RAD54L, RAD54B, RPA1
FANCM	UBE2T	Yes	activation, binding	22	ATRIP, C17ORF70, FANCD2, STRA13, FANCE, APITD1, RMI1, TOP3A, ATR, RPA1, FANCF, FANCL, FANCI, RAD1, C19ORF40, HES1, FANCB, FANCC, FANCA, BLM, UBC, FANCG
FANCM	FANCI	Yes	activation, binding	22	ATRIP, C17ORF70, FANCD2, FANCE, APITD1, UBB, RPS27A, RPA1, FANCF, UBE2T, STRA13, RAD1, UBA52, ATR, C19ORF40, HES1, FANCB, FANCC, FANCA, FANCL, UBC, FANCG
FANCM	SLX4	No	-	5	MUS81, UBC, MSH2, ERCC1, ERCC4
FANCL	RAD51C	No	-	3	BRCA1, RPA2, RPA1
FANCL	UBE2T	Yes	binding	32	ATRIP, C17ORF70, RAD9A, FANCD2, RPA1, TOPBP1, STRA13, FANCE, APITD1, RMI1, TOP3A, ATR, RAD17, BLM, RFC5, FANCF, RPA2, BRCA1, FANCI, RAD1, RFC3, C19ORF40, HES1, FANCB, FANCC, FANCA, CHEK1, FANCM, HUS1, RFC4, UBC, FANCG
FANCL	FANCI	Yes	activation, binding	33	ATRIP, C17ORF70, RAD9A, FANCD2, TOPBP1, FANCE, RPA1, UBB, RPS27A, RAD17, RFC5, FANCF, RPA2, BRCA1, UBE2T, UBA52, APITD1, STRA13, RAD1, RFC3, ATR, C19ORF40, FANCM, HES1, FANCB, FANCC, FANCA, WDR48, HUS1, FANCG, RFC4, UBC, USP1
FANCL	SLX4	No	-	1	UBC
RAD51C	UBE2T	No	-	3	BRCA1, RPA2, RPA1
RAD51C	FANCI	No	-	7	BRCA2, PALB2, RPA1, RPA2, BRCA1, H2AFX, HELQ
UBE2T	FANCI	Yes	activation, binding	28	ATRIP, C17ORF70, RAD9A, FANCD2, RPA1, TOPBP1, FANCE, APITD1, ATR, RAD17, RFC5, FANCF, RPA2, BRCA1, FANCL, STRA13, RAD1, RFC3, C19ORF40, HES1, FANCB, FANCC, FANCA, FANCM, HUS1, RFC4, UBC, FANCG
UBE2T	SLX4	No	-	1	UBC
FANCI	SLX4	No	-	1	UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
BRCA1	BRCA2	Yes	BRCC complex;BRCA1-BARD1-BRCA2-DNA damage complex III	6	BRE, HDAC2, HDAC1, BARD1, BRCC3, RAD51
BRCA1	FANCA	No	-	2	BLM, MLH1
BRCA1	ERCC4	No	-	1	MSH2
BRCA1	FANCG	No	-	2	BLM, MLH1
BRCA1	FANCF	No	-	2	BLM, MLH1
BRCA1	FANCE	No	-	2	BLM, MLH1
BRCA1	FANCC	No	-	2	BLM, MLH1
BRCA1	FANCB	No	-	1	BLM
BRCA1	FANCD2	No	-	4	ATM, NBN, MRE11A, RAD50
BRCA1	BRIP1	Yes	BRCA1-BACH1 complex	0
BRCA1	FANCL	No	-	2	BLM, MLH1
BRCA2	BRIP1	No	-	1	BRCA1
FANCA	FANCG	Yes	FA core complex (Fanconi anemia core complex);Nucleic and chromatin Fanconi complex;FA core complex 1 (Fanconi anemia core complex 1);FA complex (Fanconi anemia complex);BRAFT complex;FA complex (Fanconi anemia complex), cytoplasmic	14	FANCM, FANCC, MLH1, FANCE, RPA1, RMI1, BLM, FANCF, RPA2, FANCB, FAAP100, TOP3A, FANCL, RPA3
FANCA	FANCF	Yes	FA core complex (Fanconi anemia core complex);Nucleic and chromatin Fanconi complex;FA core complex 1 (Fanconi anemia core complex 1);FA complex (Fanconi anemia complex);BRAFT complex;FA complex (Fanconi anemia complex), cytoplasmic	14	FANCM, FANCC, MLH1, FANCE, RPA1, RMI1, BLM, FANCB, RPA2, FAAP100, TOP3A, FANCL, RPA3, FANCG
FANCA	FANCE	Yes	Nucleic and chromatin Fanconi complex;BRAFT complex;FA core complex (Fanconi anemia core complex);FA complex (Fanconi anemia complex);FA core complex 1 (Fanconi anemia core complex 1)	14	FANCC, MLH1, FANCM, RPA1, RMI1, BLM, FANCF, RPA2, FANCB, FAAP100, TOP3A, FANCL, RPA3, FANCG
FANCA	FANCC	Yes	FA core complex (Fanconi anemia core complex);Nucleic and chromatin Fanconi complex;FA core complex 1 (Fanconi anemia core complex 1);FA complex (Fanconi anemia complex);BRAFT complex;FA complex (Fanconi anemia complex), cytoplasmic	14	FANCM, MLH1, FANCE, RPA1, RMI1, BLM, FANCF, RPA2, FANCB, FAAP100, TOP3A, FANCL, RPA3, FANCG
FANCA	FANCB	Yes	FA complex (Fanconi anemia complex);FA core complex (Fanconi anemia core complex)	11	FANCM, FANCE, RPA1, RMI1, BLM, FANCF, FANCC, FAAP100, FANCL, TOP3A, FANCG
FANCA	FANCM	Yes	FA complex (Fanconi anemia complex);FA core complex (Fanconi anemia core complex)	7	FANCE, FANCB, FANCC, FANCF, FAAP100, FANCL, FANCG
FANCA	FANCL	Yes	BRAFT complex;FA core complex (Fanconi anemia core complex);FA complex (Fanconi anemia complex)	14	FANCM, FANCC, MLH1, FANCE, RPA1, RMI1, BLM, FANCF, RPA2, FANCB, FAAP100, TOP3A, RPA3, FANCG
FANCG	FANCF	Yes	FA core complex (Fanconi anemia core complex);Nucleic and chromatin Fanconi complex;FA core complex 1 (Fanconi anemia core complex 1);FA complex (Fanconi anemia complex);BRAFT complex;FA complex (Fanconi anemia complex), cytoplasmic	14	FANCA, RMI1, FANCC, MLH1, BLM, RPA1, FANCM, FANCE, FANCB, RPA2, FAAP100, TOP3A, FANCL, RPA3
FANCG	FANCE	Yes	Nucleic and chromatin Fanconi complex;BRAFT complex;FA core complex (Fanconi anemia core complex);FA complex (Fanconi anemia complex);FA core complex 1 (Fanconi anemia core complex 1)	14	FANCA, FANCC, MLH1, FANCM, RPA1, RMI1, BLM, FANCF, RPA2, FANCB, FAAP100, TOP3A, FANCL, RPA3
FANCG	FANCC	Yes	FA core complex (Fanconi anemia core complex);Nucleic and chromatin Fanconi complex;FA core complex 1 (Fanconi anemia core complex 1);FA complex (Fanconi anemia complex);BRAFT complex;FA complex (Fanconi anemia complex), cytoplasmic	14	FANCA, RMI1, MLH1, FANCE, RPA1, FANCM, BLM, FANCF, RPA2, FANCB, FAAP100, TOP3A, FANCL, RPA3
FANCG	FANCB	Yes	FA complex (Fanconi anemia complex);FA core complex (Fanconi anemia core complex)	11	FANCA, RMI1, FANCE, RPA1, FANCM, BLM, FANCF, FANCC, FAAP100, FANCL, TOP3A
FANCG	FANCM	Yes	FA complex (Fanconi anemia complex);FA core complex (Fanconi anemia core complex)	7	FANCA, FANCE, FANCB, FANCC, FANCF, FAAP100, FANCL
FANCG	FANCL	Yes	BRAFT complex;FA core complex (Fanconi anemia core complex);FA complex (Fanconi anemia complex)	14	FANCA, RMI1, FANCC, MLH1, FANCE, RPA1, FANCM, BLM, FANCF, RPA2, FANCB, FAAP100, TOP3A, RPA3
FANCF	FANCE	Yes	Nucleic and chromatin Fanconi complex;BRAFT complex;FA core complex (Fanconi anemia core complex);FA complex (Fanconi anemia complex);FA core complex 1 (Fanconi anemia core complex 1)	14	FANCA, FANCC, MLH1, FANCM, RPA1, RMI1, BLM, FANCB, RPA2, FAAP100, TOP3A, FANCL, RPA3, FANCG
FANCF	FANCC	Yes	FA core complex (Fanconi anemia core complex);Nucleic and chromatin Fanconi complex;FA core complex 1 (Fanconi anemia core complex 1);FA complex (Fanconi anemia complex);BRAFT complex;FA complex (Fanconi anemia complex), cytoplasmic	14	FANCA, RMI1, MLH1, FANCE, RPA1, FANCM, BLM, FANCB, RPA2, FAAP100, TOP3A, FANCL, RPA3, FANCG
FANCF	FANCB	Yes	FA complex (Fanconi anemia complex);FA core complex (Fanconi anemia core complex)	11	FANCA, RMI1, FANCE, RPA1, FANCM, BLM, FANCC, FAAP100, FANCL, TOP3A, FANCG
FANCF	FANCM	Yes	FA complex (Fanconi anemia complex);FA core complex (Fanconi anemia core complex)	7	FANCA, FANCE, FANCB, FANCC, FAAP100, FANCL, FANCG
FANCF	FANCL	Yes	BRAFT complex;FA core complex (Fanconi anemia core complex);FA complex (Fanconi anemia complex)	14	FANCA, RMI1, FANCC, MLH1, FANCE, RPA1, FANCM, BLM, FANCB, RPA2, FAAP100, TOP3A, RPA3, FANCG
FANCE	FANCC	Yes	Nucleic and chromatin Fanconi complex;BRAFT complex;FA core complex (Fanconi anemia core complex);FA complex (Fanconi anemia complex);FA core complex 1 (Fanconi anemia core complex 1)	14	FANCA, MLH1, FANCM, RPA1, RMI1, BLM, FANCF, RPA2, FANCB, FAAP100, TOP3A, FANCL, RPA3, FANCG
FANCE	FANCB	Yes	FA complex (Fanconi anemia complex);FA core complex (Fanconi anemia core complex)	11	FANCA, FANCM, RPA1, RMI1, BLM, FANCF, FANCC, FAAP100, FANCL, TOP3A, FANCG
FANCE	FANCM	Yes	FA complex (Fanconi anemia complex);FA core complex (Fanconi anemia core complex)	7	FANCA, FANCB, FANCC, FANCF, FAAP100, FANCL, FANCG
FANCE	FANCL	Yes	BRAFT complex;FA core complex (Fanconi anemia core complex);FA complex (Fanconi anemia complex)	14	FANCA, FANCC, MLH1, FANCM, RPA1, RMI1, BLM, FANCF, RPA2, FANCB, FAAP100, TOP3A, RPA3, FANCG
FANCC	FANCB	Yes	FA complex (Fanconi anemia complex);FA core complex (Fanconi anemia core complex)	11	FANCA, FANCE, RPA1, FANCM, BLM, FANCF, RMI1, FAAP100, FANCL, TOP3A, FANCG
FANCC	FANCM	Yes	FA complex (Fanconi anemia complex);FA core complex (Fanconi anemia core complex)	7	FANCA, FANCE, FANCB, FANCF, FAAP100, FANCL, FANCG
FANCC	FANCL	Yes	BRAFT complex;FA core complex (Fanconi anemia core complex);FA complex (Fanconi anemia complex)	14	FANCA, RMI1, MLH1, FANCE, RPA1, FANCM, BLM, FANCF, RPA2, FANCB, FAAP100, TOP3A, RPA3, FANCG
FANCB	FANCM	Yes	FA complex (Fanconi anemia complex);FA core complex (Fanconi anemia core complex)	7	FANCA, FANCE, FANCF, FANCC, FAAP100, FANCL, FANCG
FANCB	FANCL	Yes	FA complex (Fanconi anemia complex);FA core complex (Fanconi anemia core complex)	11	FANCA, RMI1, FANCE, RPA1, FANCM, BLM, FANCF, FANCC, FAAP100, TOP3A, FANCG
FANCM	FANCL	Yes	FA complex (Fanconi anemia complex);FA core complex (Fanconi anemia core complex)	7	FANCA, FANCE, FANCB, FANCC, FANCF, FAAP100, FANCG

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
BRCA1	BRIP1	Yes	2	BRCA1, BRIP1
BRCA2	PALB2	Yes	2	PALB2, BRCA2
FANCL	UBE2T	Yes	2	UBE2T, FANCL

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Fanconi anemia pathway	hsa03460	7.01	18	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, FANCD2, FANCG
Homologous recombination	hsa03440	7.91	2	BRCA2, RAD51C
Ubiquitin mediated proteolysis	hsa04120	5.63	2	BRCA1, FANCL

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Homologous recombination (hsa03440)	-	7.91	0.042	BRCA2, RAD51C
Fanconi anemia pathway (hsa03460)	-	7.01	0.0	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, FANCD2, FANCG
Genetic Information Processing	NEW	2.48	0.0	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG, FANCD2
Replication and repair	NEW	5.41	0.0	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG, FANCD2

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
DNA Repair	R-HSA-73894	5.8	16	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, FANCC, FANCB, BRCA1, BRIP1, FANCD2, FANCG
Fanconi Anemia pathway	R-HSA-419524	8.4	14	FANCA, BRCA2, UBE2T, FANCD2, FANCM, FANCI, FANCE, FANCF, FANCC, FANCB, BRCA1, FANCL, PALB2, FANCG
Double-Strand Break Repair	R-HSA-73890	8.46	3	BRCA2, BRCA1, BRIP1
Meiotic recombination	R-HSA-912446	7.25	3	BRCA1, BRCA2, RAD51C
Meiosis	R-HSA-1500620	6.59	3	BRCA1, BRCA2, RAD51C
Homologous Recombination Repair	R-HSA-73888	8.98	3	BRCA2, BRCA1, BRIP1
Cell Cycle	R-HSA-1640170	3.89	3	BRCA1, BRCA2, RAD51C
Homologous recombination repair of replication-independent double-strand breaks	R-HSA-73951	8.98	3	BRCA2, BRCA1, BRIP1
Regulation of the Fanconi anemia pathway	R-HSA-419552	9.66	2	FANCI, FANCD2
Homologous DNA Pairing and Strand Exchange	R-HSA-76010	10.18	2	BRCA2, BRIP1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Regulation of the Fanconi anemia pathway (R-HSA-419552)	-	9.66	0.011	FANCI, FANCD2
DNA Repair (R-HSA-73894)	-	5.8	0.0	FANCA, UBE2T, BRCA2, FANCL, FANCD2, FANCM, ERCC4, FANCI, FANCE, FANCF, FANCC, FANCB, BRCA1, BRIP1, PALB2, FANCG
Homologous recombination repair of replication-independent double-strand breaks (R-HSA-73951)	-	8.98	0.0	BRCA2, BRCA1, BRIP1
Homologous DNA Pairing and Strand Exchange (R-HSA-76010)	-	10.18	0.003	BRCA2, BRIP1
Meiotic recombination (R-HSA-912446)	-	7.25	0.006	BRCA1, BRCA2, RAD51C
Meiosis (R-HSA-1500620)	-	6.59	0.023	BRCA1, BRCA2, RAD51C
Cell Cycle, Mitotic (R-HSA-69278)	NEW	4.16	0.012	FANCA, BRCA2, FANCM, FANCF, FANCC, BRCA1, FANCG
Homologous Recombination Repair (R-HSA-73888)	-	8.98	0.0	BRCA2, BRCA1, BRIP1
Cell Cycle (R-HSA-1640170)	-	3.89	0.007	FANCA, BRCA2, FANCM, FANCF, RAD51C, FANCC, BRCA1, FANCG
Double-Strand Break Repair (R-HSA-73890)	-	8.46	0.001	BRCA2, BRCA1, BRIP1
Fanconi Anemia pathway (R-HSA-419524)	-	8.4	0.0	FANCA, BRCA2, UBE2T, PALB2, FANCM, FANCI, FANCE, FANCF, FANCC, FANCB, BRCA1, FANCL, FANCD2, FANCG

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	17	FANCD2, UBE2T, BRCA2, FANCL, PALB2, FANCA, ERCC4, FANCI, FANCM, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG
protein binding (GO:0005515)	0.46	17	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCI, ERCC4, FANCM, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG, FANCD2
catalytic activity (GO:0003824)	1.05	10	UBE2T, BRCA2, FANCL, ERCC4, FANCM, FANCF, BRCA1, BRIP1, SLX4, RAD51C
heterocyclic compound binding (GO:1901363)	1.06	10	FANCI, BRCA2, UBE2T, PALB2, ERCC4, FANCM, RAD51C, BRCA1, BRIP1, FANCG
organic cyclic compound binding (GO:0097159)	1.05	10	FANCI, BRCA2, UBE2T, PALB2, ERCC4, FANCM, RAD51C, BRCA1, BRIP1, FANCG
nucleic acid binding (GO:0003676)	1.44	9	FANCI, BRCA2, PALB2, ERCC4, FANCM, RAD51C, BRCA1, BRIP1, FANCG
DNA binding (GO:0003677)	1.92	9	FANCI, BRCA2, PALB2, ERCC4, FANCM, RAD51C, BRCA1, BRIP1, FANCG
enzyme binding (GO:0019899)	2.27	6	FANCI, BRCA2, UBE2T, FANCD2, BRCA1, FANCL
hydrolase activity (GO:0016787)	1.9	5	SLX4, FANCM, BRIP1, ERCC4, RAD51C
transferase activity (GO:0016740)	1.95	5	BRCA2, BRCA1, UBE2T, FANCL, FANCF
ubiquitin-like protein transferase activity (GO:0019787)	3.69	4	FANCL, BRCA1, UBE2T, FANCF
nuclease activity (GO:0004518)	4.33	4	SLX4, FANCM, RAD51C, ERCC4
adenyl nucleotide binding (GO:0030554)	2.4	4	UBE2T, FANCM, BRIP1, RAD51C
carbohydrate derivative binding (GO:0097367)	2.03	4	UBE2T, FANCM, BRIP1, RAD51C
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	4	UBE2T, FANCM, BRIP1, RAD51C
hydrolase activity, acting on ester bonds (GO:0016788)	3.1	4	SLX4, FANCM, RAD51C, ERCC4
nucleotide binding (GO:0000166)	1.96	4	UBE2T, FANCM, BRIP1, RAD51C
small molecule binding (GO:0036094)	1.89	4	UBE2T, FANCM, BRIP1, RAD51C
ribonucleotide binding (GO:0032553)	2.19	4	UBE2T, FANCM, BRIP1, RAD51C
adenyl ribonucleotide binding (GO:0032559)	2.41	4	UBE2T, FANCM, BRIP1, RAD51C
nucleoside phosphate binding (GO:1901265)	1.96	4	UBE2T, FANCM, BRIP1, RAD51C
purine nucleoside binding (GO:0001883)	2.22	4	UBE2T, FANCM, BRIP1, RAD51C
ribonucleoside binding (GO:0032549)	2.22	4	UBE2T, FANCM, BRIP1, RAD51C
purine ribonucleotide binding (GO:0032555)	2.2	4	UBE2T, FANCM, BRIP1, RAD51C
purine nucleotide binding (GO:0017076)	2.19	4	UBE2T, FANCM, BRIP1, RAD51C
ubiquitin-protein transferase activity (GO:0004842)	3.73	4	FANCL, BRCA1, UBE2T, FANCF
purine ribonucleoside binding (GO:0032550)	2.22	4	UBE2T, FANCM, BRIP1, RAD51C
ATP binding (GO:0005524)	2.43	4	UBE2T, FANCM, BRIP1, RAD51C
nucleoside binding (GO:0001882)	2.21	4	UBE2T, FANCM, BRIP1, RAD51C
cation binding (GO:0043169)	1.4	3	FANCL, BRCA1, BRIP1
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	3	FANCM, BRIP1, RAD51C
ubiquitin protein ligase binding (GO:0031625)	4.17	3	UBE2T, BRCA1, FANCL
ubiquitin-like protein ligase binding (GO:0044389)	4.15	3	UBE2T, BRCA1, FANCL
ion binding (GO:0043167)	1.36	3	FANCL, BRCA1, BRIP1
deoxyribonuclease activity (GO:0004536)	5.48	3	SLX4, RAD51C, ERCC4
endonuclease activity (GO:0004519)	4.78	3	SLX4, RAD51C, ERCC4
nucleoside-triphosphatase activity (GO:0017111)	3.09	3	FANCM, BRIP1, RAD51C
chromatin binding (GO:0003682)	3.64	3	BRCA1, UBE2T, FANCM
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	3	FANCM, BRIP1, RAD51C
endodeoxyribonuclease activity (GO:0004520)	5.81	3	SLX4, ERCC4, RAD51C
pyrophosphatase activity (GO:0016462)	3.04	3	FANCM, BRIP1, RAD51C
macromolecular complex binding (GO:0044877)	2.61	3	BRCA1, UBE2T, FANCM
damaged DNA binding (GO:0003684)	5.58	3	BRCA1, ERCC4, FANCG
metal ion binding (GO:0046872)	1.41	3	FANCL, BRCA1, BRIP1
ubiquitin protein ligase activity (GO:0061630)	4.47	3	FANCL, UBE2T, FANCF
single-stranded DNA binding (GO:0003697)	5.17	3	BRCA2, RAD51C, ERCC4
ubiquitin-like protein ligase activity (GO:0061659)	4.44	3	FANCL, UBE2T, FANCF
tubulin binding (GO:0015631)	4.1	2	BRCA1, BRCA2
DNA-dependent ATPase activity (GO:0008094)	5.31	2	BRIP1, RAD51C
DNA polymerase binding (GO:0070182)	7.25	2	FANCI, FANCD2
ATPase activity (GO:0016887)	3.65	2	BRIP1, RAD51C
cytoskeletal protein binding (GO:0008092)	3.02	2	BRCA1, BRCA2
ATPase activity, coupled (GO:0042623)	3.97	2	BRIP1, RAD51C
structure-specific DNA binding (GO:0043566)	4.98	2	ERCC4, RAD51C
helicase activity (GO:0004386)	4.69	2	FANCM, BRIP1
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters (GO:0016894)	6.74	2	SLX4, RAD51C
endodeoxyribonuclease activity, producing 3'-phosphomonoesters (GO:0016889)	7.54	2	SLX4, RAD51C
crossover junction endodeoxyribonuclease activity (GO:0008821)	7.79	2	SLX4, RAD51C
ligase activity (GO:0016874)	3.72	2	BRCA1, FANCL

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
DNA polymerase binding (GO:0070182)	-	7.25	0.002	FANCI, FANCD2
protein heterodimerization activity (GO:0046982)	NEW	3.64	0.008	FANCA, BRCA2, FANCM, ERCC4, FANCE, FANCC, BRCA1, FANCG
adenyl nucleotide binding (GO:0030554)	-	2.4	0.013	FANCA, BRCA2, UBE2T, FANCD2, ERCC4, FANCM, FANCF, RAD51C, FANCC, BRCA1, BRIP1, FANCG
protein binding (GO:0005515)	-	0.46	0.003	FANCD2, UBE2T, BRCA2, FANCL, PALB2, FANCA, ERCC4, FANCI, FANCM, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG
DNA binding (GO:0003677)	-	1.92	0.003	FANCA, BRCA2, UBE2T, FANCD2, FANCI, ERCC4, FANCM, FANCB, RAD51C, FANCC, BRCA1, BRIP1, PALB2, FANCG
chromatin binding (GO:0003682)	-	3.64	0.014	FANCA, FANCE, FANCM, FANCC, BRCA1, UBE2T, FANCG
ubiquitin-protein transferase activity (GO:0004842)	-	3.73	0.014	FANCL, BRCA1, UBE2T, FANCF
damaged DNA binding (GO:0003684)	-	5.58	0.002	BRCA1, ERCC4, FANCG
ATP binding (GO:0005524)	-	2.43	0.01	FANCA, BRCA2, UBE2T, FANCD2, ERCC4, FANCM, FANCF, RAD51C, FANCC, BRCA1, BRIP1, FANCG

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
nucleobase-containing compound metabolic process (GO:0006139)	1.35	18	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, FANCD2, FANCG
cellular response to stimulus (GO:0051716)	1.97	18	FANCA, UBE2T, BRCA2, FANCL, FANCD2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, PALB2, FANCG
primary metabolic process (GO:0044238)	0.69	18	FANCA, UBE2T, BRCA2, FANCL, FANCD2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, PALB2, FANCG
metabolic process (GO:0008152)	0.58	18	FANCA, UBE2T, BRCA2, FANCL, FANCD2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, PALB2, FANCG
cellular macromolecule metabolic process (GO:0044260)	0.93	18	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG, FANCD2
DNA repair (GO:0006281)	3.59	18	FANCD2, UBE2T, BRCA2, FANCL, PALB2, FANCA, ERCC4, FANCM, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG
nucleic acid metabolic process (GO:0090304)	1.46	18	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, FANCD2, FANCG
response to stimulus (GO:0050896)	1.22	18	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG, FANCD2
cellular process (GO:0009987)	0.26	18	FANCD2, UBE2T, BRCA2, FANCL, PALB2, FANCA, ERCC4, FANCM, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG
cellular aromatic compound metabolic process (GO:0006725)	1.3	18	FANCA, UBE2T, BRCA2, FANCL, FANCD2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, PALB2, FANCG
cellular nitrogen compound metabolic process (GO:0034641)	1.22	18	FANCA, UBE2T, BRCA2, FANCL, FANCD2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, PALB2, FANCG
cellular metabolic process (GO:0044237)	0.69	18	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG, FANCD2
macromolecule metabolic process (GO:0043170)	0.83	18	FANCD2, UBE2T, BRCA2, FANCL, PALB2, FANCA, ERCC4, FANCM, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG
cellular response to DNA damage stimulus (GO:0006974)	3.17	18	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, FANCD2, FANCG
organic substance metabolic process (GO:0071704)	0.63	18	FANCA, UBE2T, BRCA2, FANCL, FANCD2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, PALB2, FANCG
response to stress (GO:0006950)	1.8	18	FANCA, UBE2T, BRCA2, FANCL, FANCD2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, PALB2, FANCG
nitrogen compound metabolic process (GO:0006807)	1.13	18	FANCA, UBE2T, BRCA2, FANCL, FANCD2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, PALB2, FANCG
cellular response to stress (GO:0033554)	2.51	18	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, FANCD2, FANCG
DNA metabolic process (GO:0006259)	3.09	18	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, FANCD2, FANCG
organic cyclic compound metabolic process (GO:1901360)	1.26	18	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG, FANCD2
heterocycle metabolic process (GO:0046483)	1.31	18	FANCD2, UBE2T, BRCA2, FANCL, PALB2, FANCA, ERCC4, FANCM, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG
interstrand cross-link repair (GO:0036297)	5.99	13	FANCA, FANCI, UBE2T, FANCD2, FANCM, ERCC4, FANCE, FANCF, FANCC, FANCB, SLX4, FANCL, FANCG
organelle organization (GO:0006996)	2.02	12	FANCA, BRCA2, PALB2, ERCC4, FANCF, RAD51C, FANCC, SLX4, BRCA1, BRIP1, FANCD2, FANCG
single-organism process (GO:0044699)	0.48	12	FANCA, BRCA2, FANCL, PALB2, FANCI, FANCF, RAD51C, FANCC, BRCA1, BRIP1, FANCD2, FANCG
cellular component organization or biogenesis (GO:0071840)	1.22	12	FANCA, BRCA2, FANCD2, ERCC4, FANCF, RAD51C, FANCC, SLX4, BRCA1, BRIP1, PALB2, FANCG
cellular component organization (GO:0016043)	1.24	12	FANCA, BRCA2, FANCD2, ERCC4, FANCF, RAD51C, FANCC, SLX4, BRCA1, BRIP1, PALB2, FANCG
biological regulation (GO:0065007)	0.39	10	FANCA, BRCA2, FANCL, PALB2, FANCI, ERCC4, BRCA1, BRIP1, SLX4, RAD51C
cell cycle process (GO:0022402)	2.75	10	FANCA, BRCA2, FANCD2, FANCI, ERCC4, FANCM, RAD51C, BRCA1, BRIP1, FANCG
regulation of biological process (GO:0050789)	0.45	10	FANCA, BRCA2, FANCL, PALB2, FANCI, ERCC4, BRCA1, BRIP1, SLX4, RAD51C
regulation of cellular process (GO:0050794)	0.5	10	FANCA, BRCA2, FANCL, PALB2, FANCI, ERCC4, BRCA1, BRIP1, SLX4, RAD51C
reproductive process (GO:0022414)	2.55	9	FANCA, BRCA2, FANCD2, ERCC4, FANCM, FANCF, RAD51C, FANCL, FANCG
single-organism cellular process (GO:0044763)	0.65	8	FANCI, BRCA2, FANCD2, FANCF, FANCC, BRCA1, BRIP1, FANCG
chromosome organization (GO:0051276)	3.79	8	FANCD2, BRCA2, PALB2, ERCC4, BRCA1, BRIP1, SLX4, RAD51C
single organism reproductive process (GO:0044702)	2.73	7	FANCA, BRCA2, FANCD2, FANCF, RAD51C, FANCL, FANCG
double-strand break repair (GO:0006302)	4.73	7	BRCA2, PALB2, ERCC4, BRCA1, BRIP1, SLX4, RAD51C
regulation of primary metabolic process (GO:0080090)	1.08	6	FANCI, BRCA2, ERCC4, BRCA1, BRIP1, SLX4
regulation of metabolic process (GO:0019222)	1.02	6	FANCI, BRCA2, ERCC4, BRCA1, BRIP1, SLX4
response to radiation (GO:0009314)	3.69	6	BRCA2, FANCD2, ERCC4, FANCG, BRCA1, RAD51C
regulation of cellular metabolic process (GO:0031323)	1.07	6	FANCI, BRCA2, ERCC4, BRCA1, BRIP1, SLX4
meiotic cell cycle process (GO:1903046)	4.71	6	FANCA, BRCA2, FANCD2, ERCC4, FANCM, RAD51C
cellular biosynthetic process (GO:0044249)	1.37	6	BRCA2, PALB2, BRCA1, BRIP1, SLX4, RAD51C
cellular macromolecule biosynthetic process (GO:0034645)	1.66	6	BRCA2, PALB2, BRCA1, BRIP1, SLX4, RAD51C
organic substance biosynthetic process (GO:1901576)	1.34	6	BRCA2, PALB2, BRCA1, BRIP1, SLX4, RAD51C
recombinational repair (GO:0000725)	5.37	6	BRCA2, PALB2, ERCC4, BRCA1, SLX4, RAD51C
double-strand break repair via homologous recombination (GO:0000724)	5.38	6	BRCA2, PALB2, ERCC4, BRCA1, SLX4, RAD51C
positive regulation of biological process (GO:0048518)	1.2	6	FANCI, BRCA2, ERCC4, BRCA1, SLX4, RAD51C
negative regulation of biological process (GO:0048519)	1.33	6	FANCI, BRCA2, PALB2, ERCC4, BRCA1, BRIP1
developmental process (GO:0032502)	1.36	6	FANCA, BRCA2, PALB2, FANCF, BRCA1, FANCG
regulation of macromolecule metabolic process (GO:0060255)	1.08	6	FANCI, BRCA2, ERCC4, BRCA1, BRIP1, SLX4
single-organism developmental process (GO:0044767)	1.49	6	FANCA, BRCA2, PALB2, FANCF, BRCA1, FANCG
biosynthetic process (GO:0009058)	1.32	6	BRCA2, PALB2, BRCA1, BRIP1, SLX4, RAD51C
macromolecule biosynthetic process (GO:0009059)	1.61	6	BRCA2, PALB2, BRCA1, BRIP1, SLX4, RAD51C
DNA recombination (GO:0006310)	4.39	6	BRCA2, PALB2, ERCC4, BRCA1, SLX4, RAD51C
response to abiotic stimulus (GO:0009628)	2.8	6	BRCA2, FANCD2, ERCC4, FANCG, BRCA1, RAD51C
anatomical structure development (GO:0048856)	1.58	6	FANCA, BRCA2, PALB2, FANCF, BRCA1, FANCG
negative regulation of cellular process (GO:0048523)	1.41	6	FANCI, BRCA2, PALB2, ERCC4, BRCA1, BRIP1
positive regulation of cellular process (GO:0048522)	1.3	6	FANCI, BRCA2, ERCC4, BRCA1, SLX4, RAD51C
regulation of cell proliferation (GO:0042127)	2.41	5	BRCA2, BRCA1, FANCL, BRIP1, FANCA
cellular protein metabolic process (GO:0044267)	1.63	5	BRCA2, BRCA1, UBE2T, FANCL, FANCF
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	5	BRCA2, BRCA1, BRIP1, PALB2, RAD51C
multicellular organismal reproductive process (GO:0048609)	3.35	5	BRCA2, FANCD2, FANCL, RAD51C, FANCF
protein metabolic process (GO:0019538)	1.45	5	BRCA2, BRCA1, UBE2T, FANCL, FANCF
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	5	BRCA2, BRCA1, BRIP1, SLX4, ERCC4
DNA synthesis involved in DNA repair (GO:0000731)	5.42	5	BRCA2, BRCA1, BRIP1, PALB2, RAD51C
cellular protein modification process (GO:0006464)	1.79	5	UBE2T, BRCA2, BRCA1, FANCL, FANCF
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	5	BRCA2, BRCA1, BRIP1, SLX4, ERCC4
macromolecule modification (GO:0043412)	1.73	5	UBE2T, BRCA2, BRCA1, FANCL, FANCF
protein modification process (GO:0036211)	1.79	5	BRCA2, BRCA1, UBE2T, FANCL, FANCF
DNA biosynthetic process (GO:0071897)	4.89	5	BRCA2, BRCA1, BRIP1, PALB2, RAD51C
strand displacement (GO:0000732)	6.47	5	BRCA2, BRCA1, BRIP1, PALB2, RAD51C
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	5	BRCA2, BRCA1, BRIP1, PALB2, RAD51C
aromatic compound biosynthetic process (GO:0019438)	1.7	5	BRCA2, BRCA1, BRIP1, PALB2, RAD51C
organic cyclic compound biosynthetic process (GO:1901362)	1.66	5	BRCA2, BRCA1, BRIP1, PALB2, RAD51C
gamete generation (GO:0007276)	3.61	5	BRCA2, FANCD2, FANCL, FANCF, RAD51C
heterocycle biosynthetic process (GO:0018130)	1.7	5	BRCA2, BRCA1, BRIP1, PALB2, RAD51C
positive regulation of metabolic process (GO:0009893)	1.74	4	BRCA1, BRCA2, SLX4, FANCI
anatomical structure homeostasis (GO:0060249)	4.25	4	SLX4, BRCA2, ERCC4, RAD51C
macromolecular complex subunit organization (GO:0043933)	2.14	4	FANCA, BRCA2, RAD51C, FANCC
protein modification by small protein conjugation or removal (GO:0070647)	2.95	4	FANCL, BRCA1, UBE2T, FANCF
positive regulation of cellular metabolic process (GO:0031325)	1.81	4	BRCA1, BRCA2, SLX4, FANCI
homeostatic process (GO:0042592)	2.61	4	SLX4, BRCA2, ERCC4, RAD51C
cell cycle (GO:0007049)	3.14	4	BRCA1, BRCA2, FANCI, FANCD2
telomere maintenance (GO:0000723)	5.37	4	SLX4, BRCA2, ERCC4, RAD51C
response to ionizing radiation (GO:0010212)	4.74	4	BRCA1, BRCA2, FANCD2, RAD51C
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	4	BRCA1, BRCA2, SLX4, FANCI
regulation of cell cycle process (GO:0010564)	3.5	4	BRCA1, BRCA2, FANCI, RAD51C
protein modification by small protein conjugation (GO:0032446)	3.1	4	FANCL, BRCA1, UBE2T, FANCF
animal organ development (GO:0048513)	2.53	4	BRCA1, FANCA, BRCA2, PALB2
regulation of biological quality (GO:0065008)	1.68	4	SLX4, BRCA2, ERCC4, RAD51C
multicellular organismal process (GO:0032501)	1.45	4	BRCA1, BRCA2, PALB2, RAD51C
reproductive structure development (GO:0048608)	4.08	4	BRCA2, FANCA, FANCF, FANCG
regulation of DNA metabolic process (GO:0051052)	3.87	4	BRCA1, BRCA2, SLX4, ERCC4
developmental process involved in reproduction (GO:0003006)	3.36	4	BRCA2, FANCA, FANCF, FANCG
single-multicellular organism process (GO:0044707)	1.78	4	BRCA1, BRCA2, PALB2, RAD51C
cell cycle checkpoint (GO:0000075)	4.79	4	BRCA1, BRIP1, FANCI, FANCG
regulation of cell cycle (GO:0051726)	2.93	4	BRCA1, BRCA2, FANCI, RAD51C
telomere organization (GO:0032200)	5.33	4	SLX4, BRCA2, RAD51C, ERCC4
protein ubiquitination (GO:0016567)	3.28	4	FANCL, BRCA1, UBE2T, FANCF
regulation of chromosome organization (GO:0033044)	4.11	3	BRCA1, SLX4, ERCC4
response to extracellular stimulus (GO:0009991)	3.71	3	BRCA2, BRCA1, BRIP1
cellular component assembly (GO:0022607)	2.14	3	FANCA, FANCC, RAD51C
negative regulation of metabolic process (GO:0009892)	1.93	3	BRCA1, BRCA2, ERCC4
regulation of organelle organization (GO:0033043)	2.72	3	BRCA1, SLX4, ERCC4
nuclear division (GO:0000280)	3.85	3	FANCA, BRCA2, RAD51C
regulation of RNA biosynthetic process (GO:2001141)	1.55	3	BRCA2, BRCA1, BRIP1
macroautophagy (GO:0016236)	4.3	3	FANCL, FANCF, FANCC
regulation of cellular component organization (GO:0051128)	2.01	3	BRCA1, SLX4, ERCC4
embryo development (GO:0009790)	4.2	3	BRCA1, BRCA2, PALB2
chromosome breakage (GO:0031052)	8.34	3	BRCA1, BRCA2, PALB2
multicellular organism development (GO:0007275)	2.54	3	BRCA1, BRCA2, PALB2
mitochondrion organization (GO:0007005)	3.69	3	FANCF, FANCC, FANCG
meiotic nuclear division (GO:0007126)	5.37	3	FANCA, BRCA2, RAD51C
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	3	BRCA1, BRCA2, ERCC4
positive regulation of cell cycle (GO:0045787)	3.94	3	BRCA1, BRCA2, RAD51C
DNA integrity checkpoint (GO:0031570)	5.25	3	BRCA1, BRIP1, FANCI
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	3	BRCA2, BRCA1, BRIP1
macromolecular complex assembly (GO:0065003)	2.55	3	FANCA, RAD51C, FANCC
DNA replication (GO:0006260)	4.51	3	BRCA1, BRIP1, SLX4
regulation of cellular biosynthetic process (GO:0031326)	1.38	3	BRCA2, BRCA1, BRIP1
embryo development ending in birth or egg hatching (GO:0009792)	4.35	3	BRCA1, BRCA2, PALB2
chordate embryonic development (GO:0043009)	4.38	3	BRCA1, BRCA2, PALB2
response to nutrient (GO:0007584)	4.49	3	BRCA2, BRCA1, BRIP1
positive regulation of cellular component organization (GO:0051130)	2.68	3	BRCA1, SLX4, ERCC4
negative regulation of cellular metabolic process (GO:0031324)	2.01	3	BRCA1, BRCA2, ERCC4
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	3	BRCA1, BRCA2, SLX4
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	3	BRCA1, BRCA2, ERCC4
regulation of response to stimulus (GO:0048583)	1.54	3	FANCL, BRCA1, BRIP1
autophagy (GO:0006914)	3.82	3	FANCL, FANCF, FANCC
regulation of biosynthetic process (GO:0009889)	1.37	3	BRCA2, BRCA1, BRIP1
regulation of mitotic cell cycle (GO:0007346)	3.71	3	FANCI, BRCA2, RAD51C
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	3	BRCA2, BRCA1, BRIP1
nucleotide-excision repair (GO:0006289)	5.05	3	SLX4, BRCA2, ERCC4
spermatogenesis (GO:0007283)	3.7	3	BRCA2, FANCF, RAD51C
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	3	BRCA1, BRCA2, SLX4
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	3	BRCA1, BRCA2, ERCC4
male gamete generation (GO:0048232)	3.7	3	BRCA2, FANCF, RAD51C
response to chemical (GO:0042221)	1.98	3	BRCA2, BRCA1, BRIP1
DNA damage checkpoint (GO:0000077)	5.37	3	BRCA1, BRIP1, FANCI
response to external stimulus (GO:0009605)	2.55	3	BRCA2, BRCA1, BRIP1
regulation of RNA metabolic process (GO:0051252)	1.52	3	BRCA2, BRCA1, BRIP1
response to nutrient levels (GO:0031667)	3.77	3	BRCA2, BRCA1, BRIP1
regulation of gene expression (GO:0010468)	1.37	3	BRCA2, BRCA1, BRIP1
regulation of transcription, DNA-templated (GO:0006355)	1.56	3	BRCA2, BRCA1, BRIP1
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	3	BRCA2, BRCA1, BRIP1
organelle fission (GO:0048285)	3.79	3	FANCA, BRCA2, RAD51C
developmental growth (GO:0048589)	4.05	2	PALB2, BRCA2
female gonad development (GO:0008585)	6.64	2	FANCA, BRCA2
regulation of homeostatic process (GO:0032844)	3.65	2	SLX4, ERCC4
mitophagy in response to mitochondrial depolarization (GO:0098779)	4.85	2	FANCF, FANCC
signal transduction (GO:0007165)	1.28	2	BRCA1, BRCA2
multicellular organism growth (GO:0035264)	5.37	2	PALB2, BRCA2
negative regulation of cell cycle (GO:0045786)	3.67	2	BRCA1, FANCI
regulation of signal transduction (GO:0009966)	1.84	2	BRCA1, BRIP1
cellular developmental process (GO:0048869)	1.82	2	BRCA2, FANCG
peptidyl-amino acid modification (GO:0018193)	2.98	2	BRCA1, BRCA2
rhythmic process (GO:0048511)	4.02	2	FANCF, FANCG
regulation of apoptotic process (GO:0042981)	2.5	2	BRCA1, PALB2
regulation of signal transduction by p53 class mediator (GO:1901796)	4.63	2	BRCA1, BRIP1
replication fork processing (GO:0031297)	6.68	2	FANCM, BRCA2
positive regulation of DNA metabolic process (GO:0051054)	4.49	2	BRCA1, SLX4
negative regulation of DNA metabolic process (GO:0051053)	4.98	2	BRCA2, ERCC4
negative regulation of cell death (GO:0060548)	2.95	2	BRCA1, PALB2
centrosome organization (GO:0051297)	5.38	2	BRCA1, BRCA2
response to organic substance (GO:0010033)	2.2	2	BRCA1, BRCA2
peptidyl-lysine modification (GO:0018205)	3.98	2	BRCA1, BRCA2
positive regulation of organelle organization (GO:0010638)	3.38	2	BRCA1, SLX4
negative regulation of organelle organization (GO:0010639)	4.07	2	BRCA1, ERCC4
resolution of meiotic recombination intermediates (GO:0000712)	7.43	2	FANCM, ERCC4
protein autoubiquitination (GO:0051865)	5.84	2	BRCA1, UBE2T
DNA-dependent DNA replication maintenance of fidelity (GO:0045005)	6.55	2	FANCM, BRCA2
negative regulation of biosynthetic process (GO:0009890)	2.47	2	BRCA1, BRCA2
positive regulation of biosynthetic process (GO:0009891)	2.29	2	BRCA1, BRCA2
organelle disassembly (GO:1903008)	4.52	2	FANCF, FANCC
positive regulation of gene expression (GO:0010628)	2.35	2	BRCA1, BRCA2
intracellular signal transduction (GO:0035556)	2.39	2	BRCA1, BRCA2
signal transduction by p53 class mediator (GO:0072331)	4.88	2	BRCA1, BRCA2
positive regulation of cell cycle process (GO:0090068)	4.25	2	BRCA1, RAD51C
G2 DNA damage checkpoint (GO:0031572)	6.26	2	BRCA1, FANCI
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	2	BRCA1, BRIP1
gonad development (GO:0008406)	4.92	2	FANCA, BRCA2
regulation of developmental process (GO:0050793)	2.1	2	BRCA1, BRCA2
regulation of cell cycle phase transition (GO:1901987)	4.15	2	FANCI, RAD51C
regulation of multicellular organismal process (GO:0051239)	1.87	2	BRCA1, BRCA2
regulation of intracellular signal transduction (GO:1902531)	2.31	2	BRCA1, BRIP1
ovarian follicle development (GO:0001541)	5.82	2	FANCF, FANCG
brain development (GO:0007420)	4.24	2	BRCA1, BRCA2
regulation of response to stress (GO:0080134)	2.53	2	BRCA1, FANCL
positive regulation of protein modification process (GO:0031401)	2.7	2	BRCA1, FANCI
protein monoubiquitination (GO:0006513)	5.8	2	UBE2T, FANCL
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	2	BRCA1, BRCA2
protein K6-linked ubiquitination (GO:0085020)	7.65	2	BRCA1, UBE2T
positive regulation of chromosome organization (GO:2001252)	4.76	2	BRCA1, SLX4
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	2	BRCA1, BRCA2
negative regulation of chromosome organization (GO:2001251)	5.17	2	BRCA1, ERCC4
negative regulation of cellular component organization (GO:0051129)	3.35	2	BRCA1, ERCC4
response to UV (GO:0009411)	4.88	2	BRCA2, ERCC4
response to light stimulus (GO:0009416)	4.08	2	BRCA2, ERCC4
regulation of mitotic cell cycle phase transition (GO:1901990)	4.23	2	FANCI, RAD51C
cellular response to chemical stimulus (GO:0070887)	2.57	2	BRCA1, BRIP1
regulation of signaling (GO:0023051)	1.72	2	BRCA1, BRIP1
regulation of cell communication (GO:0010646)	1.73	2	BRCA1, BRIP1
protein polyubiquitination (GO:0000209)	4.23	2	BRCA1, UBE2T
response to organic cyclic compound (GO:0014070)	3.07	2	BRCA1, BRCA2
response to endogenous stimulus (GO:0009719)	2.79	2	BRCA1, SLX4
telomere maintenance via recombination (GO:0000722)	6.26	2	BRCA2, RAD51C
meiosis I (GO:0007127)	6.47	2	BRCA2, RAD51C
ovulation cycle process (GO:0022602)	5.25	2	FANCF, FANCG
DNA double-strand break processing (GO:0000729)	6.78	2	BRCA1, SLX4
regulation of protein metabolic process (GO:0051246)	1.93	2	BRCA1, FANCI
positive regulation of protein metabolic process (GO:0051247)	2.43	2	BRCA1, FANCI
regulation of protein modification by small protein conjugation or removal (GO:1903320)	4.14	2	BRCA1, FANCI
positive regulation of protein modification by small protein conjugation or removal (GO:1903322)	4.48	2	BRCA1, FANCI
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	2	BRCA1, FANCI
positive regulation of protein ubiquitination (GO:0031398)	4.55	2	BRCA1, FANCI
regulation of protein modification process (GO:0031399)	2.32	2	BRCA1, FANCI
regulation of protein ubiquitination (GO:0031396)	4.22	2	BRCA1, FANCI
cellular response to endogenous stimulus (GO:0071495)	3.33	2	BRCA1, SLX4
negative regulation of cell proliferation (GO:0008285)	3.26	2	BRCA2, BRIP1
microtubule organizing center organization (GO:0031023)	5.26	2	BRCA1, BRCA2
cell proliferation (GO:0008283)	3.23	2	PALB2, BRCA2
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	2	BRCA1, BRCA2
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator (GO:0006978)	7.09	2	BRCA1, BRCA2
chromosome organization involved in meiotic cell cycle (GO:0070192)	5.9	2	FANCD2, RAD51C
regulation of cellular protein metabolic process (GO:0032268)	1.99	2	BRCA1, FANCI
intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630)	5.44	2	BRCA1, BRCA2
mitophagy (GO:0000422)	4.63	2	FANCF, FANCC
macromitophagy (GO:0000423)	4.85	2	FANCF, FANCC
positive regulation of RNA metabolic process (GO:0051254)	2.51	2	BRCA1, BRCA2
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	2	BRCA1, BRCA2
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	2	BRCA1, BRCA2
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	2	BRCA1, BRCA2
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	2	BRCA1, BRCA2
apoptotic signaling pathway (GO:0097190)	4.12	2	BRCA1, BRCA2
intrinsic apoptotic signaling pathway (GO:0097193)	4.69	2	BRCA1, BRCA2
nucleic acid phosphodiester bond hydrolysis (GO:0090305)	4.12	2	FANCM, ERCC4
negative regulation of cell cycle process (GO:0010948)	4.37	2	BRCA1, FANCI
regulation of cell death (GO:0010941)	2.43	2	BRCA1, PALB2
male meiosis I (GO:0007141)	6.9	2	BRCA2, RAD51C
response to estradiol (GO:0032355)	4.73	2	BRCA1, BRCA2
growth (GO:0040007)	3.8	2	PALB2, BRCA2
protein complex subunit organization (GO:0071822)	2.6	2	FANCA, FANCC
response to lipid (GO:0033993)	3.11	2	BRCA1, BRCA2
response to gamma radiation (GO:0010332)	5.78	2	FANCD2, BRCA2
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	2	BRCA1, BRCA2
regulation of programmed cell death (GO:0043067)	2.49	2	BRCA1, PALB2
negative regulation of apoptotic process (GO:0043066)	3.04	2	BRCA1, PALB2
regulation of cell cycle G2/M phase transition (GO:1902749)	5.63	2	FANCI, RAD51C
negative regulation of programmed cell death (GO:0043069)	3.02	2	BRCA1, PALB2
positive regulation of mitotic cell cycle (GO:0045931)	4.98	2	BRCA2, RAD51C
DNA damage response, signal transduction by p53 class mediator (GO:0030330)	5.3	2	BRCA1, BRCA2
mitochondrion disassembly (GO:0061726)	4.63	2	FANCF, FANCC
protein complex assembly (GO:0006461)	2.78	2	FANCA, FANCC
cellular component disassembly (GO:0022411)	3.52	2	FANCF, FANCC
cellular process involved in reproduction in multicellular organism (GO:0022412)	4.3	2	BRCA2, FANCG
DNA damage response, signal transduction resulting in transcription (GO:0042772)	7.02	2	BRCA1, BRCA2
regulation of G2/M transition of mitotic cell cycle (GO:0010389)	5.76	2	FANCI, RAD51C
signal transduction in response to DNA damage (GO:0042770)	5.15	2	BRCA1, BRCA2
response to oxygen-containing compound (GO:1901700)	2.57	2	BRCA1, BRCA2
mitotic recombination (GO:0006312)	6.04	2	BRCA2, RAD51C
regulation of telomere maintenance (GO:0032204)	5.54	2	SLX4, ERCC4
inner cell mass cell proliferation (GO:0001833)	7.33	2	PALB2, BRCA2
regulation of cellular component biogenesis (GO:0044087)	3.08	2	BRCA1, ERCC4
single-organism organelle organization (GO:1902589)	2.68	2	FANCF, FANCC
regulation of multicellular organismal development (GO:2000026)	2.31	2	BRCA1, BRCA2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
DNA catabolic process, endonucleolytic (GO:0000737)	NEW	6.78	0.021	SLX4, ERCC4, RAD51C
response to radiation (GO:0009314)	-	3.69	0.028	BRCA1, BRCA2, ERCC4, FANCG, FANCD2
meiotic cell cycle process (GO:1903046)	-	4.71	0.0	FANCA, BRCA2, FANCD2, ERCC4, FANCM, FANCC, BRCA1, RAD51C
nucleic acid metabolic process (GO:0090304)	-	1.46	0.0	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG, FANCD2
nucleic acid phosphodiester bond hydrolysis (GO:0090305)	-	4.12	0.047	SLX4, FANCM, RAD51C, ERCC4
cellular nitrogen compound metabolic process (GO:0034641)	-	1.22	0.0	FANCA, UBE2T, BRCA2, FANCL, FANCD2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, PALB2, FANCG
nitrogen compound metabolic process (GO:0006807)	-	1.13	0.0	FANCD2, UBE2T, BRCA2, FANCL, PALB2, FANCA, ERCC4, FANCM, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG
cell cycle process (GO:0022402)	-	2.75	0.001	FANCA, BRCA2, FANCD2, FANCM, ERCC4, FANCI, FANCE, RAD51C, FANCC, BRCA1, BRIP1, FANCG
glutamine family amino acid catabolic process (GO:0009065)	NEW	6.55	0.013	BRCA1, FANCE, FANCC
meiotic chromosome separation (GO:0051307)	NEW	9.04	0.001	FANCM, FANCA, ERCC4
mitotic nuclear division (GO:0007067)	NEW	4.05	0.013	FANCA, FANCE, FANCM, FANCB, FANCC, BRCA1
chromosome separation (GO:0051304)	NEW	7.43	0.005	FANCM, FANCA, ERCC4
cell cycle (GO:0007049)	-	3.14	0.001	FANCA, BRCA2, FANCM, FANCI, FANCE, FANCF, FANCC, BRCA1, FANCG
male meiosis I (GO:0007141)	-	6.9	0.009	BRCA1, BRCA2, RAD51C
nucleobase-containing compound metabolic process (GO:0006139)	-	1.35	0.0	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, FANCD2, FANCG
cellular response to stimulus (GO:0051716)	-	1.97	0.0	FANCA, UBE2T, BRCA2, FANCL, FANCD2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, PALB2, FANCG
meiosis I (GO:0007127)	-	6.47	0.018	BRCA1, BRCA2, RAD51C
double-strand break repair (GO:0006302)	-	4.73	0.0	FANCD2, BRCA2, PALB2, FANCI, ERCC4, RAD51C, BRCA1, BRIP1, SLX4, FANCG
recombinational repair (GO:0000725)	-	5.37	0.0	FANCD2, BRCA2, PALB2, FANCI, ERCC4, RAD51C, BRCA1, SLX4, FANCG
double-strand break repair via homologous recombination (GO:0000724)	-	5.38	0.0	FANCD2, BRCA2, PALB2, FANCI, ERCC4, RAD51C, BRCA1, SLX4, FANCG
organic cyclic compound metabolic process (GO:1901360)	-	1.26	0.0	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG, FANCD2
nuclear division (GO:0000280)	-	3.85	0.014	FANCA, BRCA2, FANCE, FANCM, FANCC, BRCA1, RAD51C
arginine metabolic process (GO:0006525)	NEW	6.84	0.004	BRCA1, FANCE, FANCC
regulation of protein modification by small protein conjugation or removal (GO:1903320)	-	4.14	0.0	FANCA, BRCA2, FANCI, FANCM, FANCC, BRCA1, FANCL, FANCG
organic substance metabolic process (GO:0071704)	-	0.63	0.004	FANCD2, UBE2T, BRCA2, FANCL, PALB2, FANCA, ERCC4, FANCM, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG
positive regulation of protein modification by small protein conjugation or removal (GO:1903322)	-	4.48	0.0	FANCA, FANCI, FANCM, FANCC, BRCA1, FANCG
DNA replication (GO:0006260)	-	4.51	0.003	FANCA, FANCD2, ERCC4, FANCM, SLX4, BRCA1
gamete generation (GO:0007276)	-	3.61	0.015	BRCA2, FANCD2, FANCL, RAD51C, FANCF
positive regulation of protein ubiquitination (GO:0031398)	-	4.55	0.0	FANCA, FANCI, FANCM, FANCC, BRCA1, FANCG
regulation of protein ubiquitination (GO:0031396)	-	4.22	0.0	FANCA, FANCI, FANCM, FANCC, BRCA1, FANCL, FANCG
mitotic cell cycle (GO:0000278)	NEW	5.92	0.032	FANCA, BRCA2, FANCF, FANCC, BRCA1, FANCG
DNA repair (GO:0006281)	-	3.59	0.0	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, FANCD2, FANCG
aromatic compound catabolic process (GO:0019439)	NEW	3.79	0.046	FANCA, BRCA2, ERCC4, FANCM, RAD51C, FANCC, BRCA1, BRIP1, SLX4, FANCG
cellular macromolecule metabolic process (GO:0044260)	-	0.93	0.0	FANCA, UBE2T, BRCA2, FANCL, FANCD2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, PALB2, FANCG
cellular aromatic compound metabolic process (GO:0006725)	-	1.3	0.0	FANCA, UBE2T, BRCA2, FANCL, FANCD2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, PALB2, FANCG
single-organism metabolic process (GO:0044710)	NEW	1.63	0.0	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG, FANCD2
nucleotide-excision repair (GO:0006289)	-	5.05	0.001	SLX4, FANCM, BRCA2, ERCC4, FANCC
cellular response to DNA damage stimulus (GO:0006974)	-	3.17	0.0	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG, FANCD2
reproductive process (GO:0022414)	-	2.55	0.002	FANCA, BRCA2, FANCD2, FANCF, RAD51C, FANCC, FANCL, FANCG
response to stress (GO:0006950)	-	1.8	0.0	FANCD2, UBE2T, BRCA2, FANCL, PALB2, FANCA, ERCC4, FANCM, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG
single-organism cellular process (GO:0044763)	-	0.65	0.004	FANCA, UBE2T, BRCA2, FANCL, FANCD2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, PALB2, FANCG
metabolic process (GO:0008152)	-	0.58	0.042	FANCA, UBE2T, BRCA2, FANCL, FANCD2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, PALB2, FANCG
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator (GO:0006978)	-	7.09	0.044	BRCA1, BRCA2
heterocycle metabolic process (GO:0046483)	-	1.31	0.0	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, FANCD2, FANCG
DNA recombination (GO:0006310)	-	4.39	0.0	FANCD2, BRCA2, PALB2, FANCI, ERCC4, FANCM, RAD51C, BRCA1, SLX4, FANCG
primary metabolic process (GO:0044238)	-	0.69	0.003	FANCA, UBE2T, BRCA2, FANCL, FANCD2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, PALB2, FANCG
single organism reproductive process (GO:0044702)	-	2.73	0.001	FANCA, BRCA2, FANCD2, FANCF, RAD51C, FANCC, FANCL, FANCG
chromosome organization involved in meiosis (GO:0070192)	-	5.9	0.045	BRCA1, FANCD2, RAD51C
resolution of meiotic recombination intermediates (GO:0000712)	-	7.43	0.001	FANCM, FANCA, ERCC4
response to stimulus (GO:0050896)	-	1.22	0.0	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG, FANCD2
inner cell mass cell proliferation (GO:0001833)	-	7.33	0.001	BRCA1, BRCA2, PALB2
cellular metabolic process (GO:0044237)	-	0.69	0.001	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG, FANCD2
macromolecule metabolic process (GO:0043170)	-	0.83	0.0	FANCD2, UBE2T, BRCA2, FANCL, PALB2, FANCA, ERCC4, FANCM, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG
protein K6-linked ubiquitination (GO:0085020)	-	7.65	0.01	BRCA1, UBE2T
organelle fission (GO:0048285)	-	3.79	0.002	FANCA, BRCA2, FANCE, FANCM, FANCC, BRCA1, FANCL, RAD51C
cellular response to stress (GO:0033554)	-	2.51	0.0	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, FANCD2, FANCG
DNA metabolic process (GO:0006259)	-	3.09	0.0	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG, FANCD2

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
intracellular organelle part (GO:0044446)	0.81	18	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, FANCD2, FANCG
intracellular membrane-bounded organelle (GO:0043231)	0.6	18	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG, FANCD2
nucleus (GO:0005634)	1.07	18	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, FANCD2, FANCG
cell part (GO:0044464)	0.11	18	FANCD2, UBE2T, BRCA2, FANCL, PALB2, FANCA, ERCC4, FANCM, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG
nucleoplasm (GO:0005654)	1.89	18	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG, FANCD2
intracellular organelle (GO:0043229)	0.51	18	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG, FANCD2
nuclear part (GO:0044428)	1.55	18	FANCD2, UBE2T, BRCA2, FANCL, PALB2, FANCA, ERCC4, FANCM, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG
intracellular part (GO:0044424)	0.28	18	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG, FANCD2
membrane-bounded organelle (GO:0043227)	0.47	18	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG, FANCD2
organelle (GO:0043226)	0.4	18	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG, FANCD2
organelle part (GO:0044422)	0.79	18	FANCD2, UBE2T, BRCA2, FANCL, PALB2, FANCA, ERCC4, FANCM, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG
protein complex (GO:0043234)	1.51	13	FANCA, BRCA2, FANCM, ERCC4, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, FANCL, SLX4, FANCG
macromolecular complex (GO:0032991)	1.35	13	FANCA, BRCA2, FANCM, ERCC4, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, FANCL, SLX4, FANCG
cytoplasm (GO:0005737)	1.01	12	FANCA, UBE2T, BRCA2, FANCL, FANCD2, FANCI, RAD51C, FANCC, BRCA1, BRIP1, SLX4, FANCG
nucleoplasm part (GO:0044451)	3.22	9	FANCA, FANCM, ERCC4, FANCE, FANCB, FANCC, FANCF, FANCL, FANCG
Fanconi anaemia nuclear complex (GO:0043240)	7.24	8	FANCA, FANCM, FANCE, FANCB, FANCC, FANCF, FANCL, FANCG
non-membrane-bounded organelle (GO:0043228)	1.76	5	BRCA1, BRCA2, RAD51C, FANCG, FANCD2
membrane (GO:0016020)	0.68	5	BRIP1, BRCA1, BRCA2, FANCI, FANCG
chromosomal part (GO:0044427)	3.18	5	FANCC, SLX4, BRCA2, ERCC4, RAD51C
cytoplasmic part (GO:0044444)	0.82	5	RAD51C, BRCA1, BRCA2, FANCC, FANCG
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	5	BRCA1, BRCA2, RAD51C, FANCG, FANCD2
nuclear chromosome part (GO:0044454)	3.67	3	SLX4, BRCA2, ERCC4
chromosome, telomeric region (GO:0000781)	4.9	3	SLX4, BRCA2, ERCC4
condensed chromosome (GO:0000793)	5.64	3	BRCA1, FANCD2, RAD51C
nuclear chromosome, telomeric region (GO:0000784)	5.16	3	SLX4, BRCA2, ERCC4
chromosome (GO:0005694)	3.78	3	BRCA1, FANCD2, RAD51C
chromosomal region (GO:0098687)	4.19	3	SLX4, BRCA2, ERCC4
nucleotide-excision repair complex (GO:0000109)	7.61	2	SLX4, ERCC4
nucleolus (GO:0005730)	3.06	2	FANCD2, FANCG
DNA repair complex (GO:1990391)	6.14	2	SLX4, ERCC4
integral component of membrane (GO:0016021)	1.14	2	BRCA1, BRCA2
mitochondrion (GO:0005739)	2.42	2	RAD51C, FANCG
cytoskeletal part (GO:0044430)	2.49	2	BRCA1, BRCA2
chromatin (GO:0000785)	3.99	2	SLX4, FANCC
condensed nuclear chromosome (GO:0000794)	6.11	2	BRCA1, RAD51C
plasma membrane (GO:0005886)	1.39	2	BRCA1, FANCG
ERCC4-ERCC1 complex (GO:0070522)	8.7	2	SLX4, ERCC4
membrane part (GO:0044425)	0.95	2	BRCA1, BRCA2
nuclear chromosome (GO:0000228)	5.55	2	BRCA1, RAD51C
Holliday junction resolvase complex (GO:0048476)	8.19	2	SLX4, RAD51C
intrinsic component of membrane (GO:0031224)	1.13	2	BRCA1, BRCA2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
protein complex (GO:0043234)	-	1.51	0.0	FANCA, BRCA2, FANCM, ERCC4, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, FANCL, SLX4, FANCG
nucleoplasm (GO:0005654)	-	1.89	0.0	FANCA, UBE2T, BRCA2, FANCL, FANCD2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, PALB2, FANCG
macromolecular complex (GO:0032991)	-	1.35	0.003	FANCA, BRCA2, FANCM, ERCC4, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, FANCL, SLX4, FANCG
nucleus (GO:0005634)	-	1.07	0.023	FANCA, BRCA2, UBE2T, PALB2, FANCM, ERCC4, FANCE, FANCC, SLX4, BRCA1, BRIP1, FANCD2, RAD51C
intracellular organelle part (GO:0044446)	-	0.81	0.0	FANCA, UBE2T, BRCA2, FANCL, PALB2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, FANCD2, FANCG
nuclear part (GO:0044428)	-	1.55	0.0	FANCD2, UBE2T, BRCA2, FANCL, PALB2, FANCA, ERCC4, FANCM, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, BRIP1, SLX4, FANCG
nucleoplasm part (GO:0044451)	-	3.22	0.0	FANCA, UBE2T, FANCL, FANCM, ERCC4, FANCE, FANCF, FANCC, FANCB, BRCA1, BRIP1, FANCG
chromosomal part (GO:0044427)	-	3.18	0.0	FANCA, BRCA2, FANCM, ERCC4, FANCE, RAD51C, FANCC, BRCA1, SLX4, FANCG
chromosome (GO:0005694)	-	3.78	0.0	FANCA, BRCA2, FANCD2, ERCC4, FANCC, BRCA1, FANCG
Fanconi anaemia nuclear complex (GO:0043240)	-	7.24	0.0	FANCA, FANCM, FANCE, FANCB, FANCC, FANCF, FANCL, FANCG
organelle part (GO:0044422)	-	0.79	0.0	FANCA, UBE2T, BRCA2, FANCL, FANCD2, FANCM, ERCC4, FANCI, FANCE, FANCF, RAD51C, FANCC, FANCB, BRCA1, SLX4, BRIP1, PALB2, FANCG