Disease table of BARE LYMPHOCYTE SYNDROME, TYPE I OMIM ID: 604571

Gene-disease associations table

GeneAssociated with BARE LYMPHOCYTE SYNDROME, TYPE I inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
TAP1ClinVar, OMIMHGNC link6p21.321604571
TAPBPOMIMHGNC link6p21.321604571
TAP2ClinVar, OMIMHGNC link6p21.321604571

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Common tandem groupNumber of genes in this tandem group associated to this diseaseGenes in this tandem group associated to this disease
Group 2932TAP1, TAP2
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
6p21.323TAP1, TAPBP, TAP2
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
6p213TAP1, TAPBP, TAP2
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
6p23TAP1, TAPBP, TAP2
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
6p3TAP1, TAPBP, TAP2
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
63TAP1, TAPBP, TAP2
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
IRF1NO51EIF2AK2, IFNA13, PSMB10, IL12A, NCF2, CEACAM1, MMP9, MYB, PSMB9, IL12B, TAP2, CCNE1, CCL5, SOCS2, VCAM1, TNFSF10, SOCS1, MAPK14, IFNA1, HLA-G, CASP7, CDKN1A, IFNB1, CCNB1, FOXP3, OGN, PIGR, IL10, TAP1, TP53, TRIM22, HLA-A, DDX58, CD40, ERAP2, IL27, CDK1, E2F1, TAPBP, CYBB, CDK2, BCL2, CDK4, CXCL10, SLPI, IRF2, DST, IFIT3, CIITA, IFNG, FASLG3TAPBP, TAP2, TAP1
RELANO302NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC63TAPBP, TAP2, TAP1
NFKB1NO306NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC63TAPBP, TAP2, TAP1
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
TAP1YES5NFKB1, IRF2, STAT1, IRF1, RELA0
TAPBPYES3IRF1, NFKB1, RELA0
TAP2YES3IRF1, NFKB1, RELA0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
TAP1TAPBPYes7TAP2, COPG1, CALR, HLA-A, B2M, COPB1, PDIA3
TAP1TAP2Yes7TAPBP, TCTN3, HLA-A, B2M, HLA-G, PSMB8, ATL3
TAPBPTAP2Yes3B2M, HLA-A, TAP1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
TAP1TAP2yes, complexTAP1 and TAP2 form a heterodimer. [UniProt]
TAP1TAPBPyes, they interactHeterodimer of TAP1 and TAP2 interacts with�TAPBP. [UniProt]
TAP2TAPBPyes, they interactHeterodimer of TAP1 and TAP2 interacts with�TAPBP. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Antigen processing and presentationhsa046126.043TAPBP, TAP2, TAP1
Primary immunodeficiencyhsa053407.522TAP2, TAP1
ABC transportershsa020107.282TAP2, TAP1
Phagosomehsa041455.272TAP2, TAP1
Herpes simplex infectionhsa051685.082TAP2, TAP1

NET-GE enrichment

Term New enriched termICP valueGenes
ABC transporters (hsa02010) -7.280.003TAP2, TAP1
Antigen processing and presentation (hsa04612) -6.040.0TAPBP, TAP2, TAP1
Membrane transportNEW7.280.002TAP2, TAP1
Phagosome (hsa04145) -5.270.03TAP2, TAP1
Immune systemNEW2.920.034TAPBP, TAP2, TAP1
Primary immunodeficiency (hsa05340) -7.520.001TAP2, TAP1
Herpes simplex infection (hsa05168) -5.080.038TAP2, TAP1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Immune SystemR-HSA-1682562.373TAPBP, TAP2, TAP1
Antigen processing-Cross presentationR-HSA-12369755.883TAPBP, TAP2, TAP1
ER-Phagosome pathwayR-HSA-12369746.083TAPBP, TAP2, TAP1
Class I MHC mediated antigen processing & presentationR-HSA-9831694.653TAPBP, TAP2, TAP1
Antigen Presentation: Folding, assembly and peptide loading of class I MHCR-HSA-9831706.643TAPBP, TAP2, TAP1
Adaptive Immune SystemR-HSA-12802183.193TAPBP, TAP2, TAP1

NET-GE enrichment

Term New enriched termICP valueGenes
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (R-HSA-983170) -6.640.0TAPBP, TAP2, TAP1
Class I MHC mediated antigen processing & presentation (R-HSA-983169) -4.650.0TAPBP, TAP2, TAP1
Antigen processing-Cross presentation (R-HSA-1236975) -5.880.0TAPBP, TAP2, TAP1
ER-Phagosome pathway (R-HSA-1236974) -6.080.0TAPBP, TAP2, TAP1
Adaptive Immune System (R-HSA-1280218) -3.190.009TAPBP, TAP2, TAP1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
peptide-transporting ATPase activity (GO:0015440) 8.133TAPBP, TAP2, TAP1
binding (GO:0005488) 0.183TAPBP, TAP2, TAP1
ATPase activity (GO:0016887) 3.653TAPBP, TAP2, TAP1
TAP binding (GO:0046977) 7.793TAPBP, TAP2, TAP1
TAP1 binding (GO:0046978) 8.353TAPBP, TAP2, TAP1
ATPase activity, coupled to transmembrane movement of substances (GO:0042626) 5.063TAPBP, TAP2, TAP1
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances (GO:0016820) 5.033TAPBP, TAP2, TAP1
ATPase activity, coupled (GO:0042623) 3.973TAPBP, TAP2, TAP1
primary active transmembrane transporter activity (GO:0015399) 4.983TAPBP, TAP2, TAP1
MHC protein binding (GO:0042287) 6.183TAPBP, TAP2, TAP1
active transmembrane transporter activity (GO:0022804) 3.853TAPBP, TAP2, TAP1
hydrolase activity (GO:0016787) 1.93TAPBP, TAP2, TAP1
transporter activity (GO:0005215) 2.573TAPBP, TAP2, TAP1
nucleoside-triphosphatase activity (GO:0017111) 3.093TAPBP, TAP2, TAP1
catalytic activity (GO:0003824) 1.053TAPBP, TAP2, TAP1
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 3.033TAPBP, TAP2, TAP1
ATPase activity, coupled to movement of substances (GO:0043492) 4.933TAPBP, TAP2, TAP1
hydrolase activity, acting on acid anhydrides (GO:0016817) 3.033TAPBP, TAP2, TAP1
pyrophosphatase activity (GO:0016462) 3.043TAPBP, TAP2, TAP1
transmembrane transporter activity (GO:0022857) 2.823TAPBP, TAP2, TAP1
protein binding (GO:0005515) 0.463TAPBP, TAP2, TAP1
receptor binding (GO:0005102) 2.433TAPBP, TAP2, TAP1
P-P-bond-hydrolysis-driven transmembrane transporter activity (GO:0015405) 4.983TAPBP, TAP2, TAP1
purine ribonucleoside triphosphate binding (GO:0035639) 2.222TAP2, TAP1
TAP2 binding (GO:0046979) 8.642TAPBP, TAP1
heterocyclic compound binding (GO:1901363) 1.062TAP2, TAP1
nucleoside phosphate binding (GO:1901265) 1.962TAP2, TAP1
nucleoside binding (GO:0001882) 2.212TAP2, TAP1
peptide binding (GO:0042277) 4.222TAPBP, TAP1
peptide antigen-transporting ATPase activity (GO:0015433) 9.052TAPBP, TAP2
peptide antigen binding (GO:0042605) 6.182TAPBP, TAP1
nucleotide binding (GO:0000166) 1.962TAP2, TAP1
purine nucleoside binding (GO:0001883) 2.222TAP2, TAP1
ribonucleoside binding (GO:0032549) 2.222TAP2, TAP1
purine nucleotide binding (GO:0017076) 2.192TAP2, TAP1
ATP binding (GO:0005524) 2.432TAP2, TAP1
MHC class I protein binding (GO:0042288) 6.852TAPBP, TAP1
amide binding (GO:0033218) 4.142TAPBP, TAP1
small molecule binding (GO:0036094) 1.892TAP2, TAP1
antigen binding (GO:0003823) 5.022TAPBP, TAP1
peptide transporter activity (GO:0015197) 7.442TAP2, TAP1
MHC class Ib protein binding (GO:0023029) 8.352TAP2, TAP1
substrate-specific transporter activity (GO:0022892) 2.722TAP2, TAP1
adenyl nucleotide binding (GO:0030554) 2.42TAP2, TAP1
carbohydrate derivative binding (GO:0097367) 2.032TAP2, TAP1
organic cyclic compound binding (GO:0097159) 1.052TAP2, TAP1
adenyl ribonucleotide binding (GO:0032559) 2.412TAP2, TAP1
purine ribonucleotide binding (GO:0032555) 2.22TAP2, TAP1
tapasin binding (GO:0046980) 9.052TAP2, TAP1
purine ribonucleoside binding (GO:0032550) 2.222TAP2, TAP1
ribonucleotide binding (GO:0032553) 2.192TAP2, TAP1

NET-GE enrichment

Term New enriched termICP valueGenes
peptide-transporting ATPase activity (GO:0015440) -8.130.0TAPBP, TAP2
ATPase activity (GO:0016887) -3.650.001TAPBP, TAP2, TAP1
TAP binding (GO:0046977) -7.790.0TAPBP, TAP2, TAP1
TAP1 binding (GO:0046978) -8.350.0TAPBP, TAP2, TAP1
TAP2 binding (GO:0046979) -8.640.0TAPBP, TAP1
ATPase activity, coupled to transmembrane movement of substances (GO:0042626) -5.060.0TAPBP, TAP2, TAP1
amide transmembrane transporter activity (GO:0042887) NEW6.970.0TAPBP, TAP2
peptide binding (GO:0042277) -4.220.029TAPBP, TAP1
MHC class I protein binding (GO:0042288) -6.850.0TAPBP, TAP1
ATPase activity, coupled (GO:0042623) -3.970.002TAPBP, TAP2, TAP1
primary active transmembrane transporter activity (GO:0015399) -4.980.0TAPBP, TAP2, TAP1
amide binding (GO:0033218) -4.140.031TAPBP, TAP1
active transmembrane transporter activity (GO:0022804) -3.850.0TAPBP, TAP2, TAP1
peptide antigen-transporting ATPase activity (GO:0015433) -9.050.0TAPBP, TAP2
transporter activity (GO:0005215) -2.570.024TAPBP, TAP2, TAP1
nucleoside-triphosphatase activity (GO:0017111) -3.090.005TAPBP, TAP2, TAP1
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances (GO:0016820) -5.030.0TAPBP, TAP2, TAP1
antigen binding (GO:0003823) -5.020.04TAPBP, TAP1
peptide transporter activity (GO:0015197) -7.440.0TAPBP, TAP2, TAP1
MHC class Ib protein binding (GO:0023029) -8.350.0TAP2, TAP1
MHC protein binding (GO:0042287) -6.180.0TAPBP, TAP2, TAP1
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) -3.030.006TAPBP, TAP2, TAP1
substrate-specific transporter activity (GO:0022892) -2.720.012TAPBP, TAP2, TAP1
ATPase activity, coupled to movement of substances (GO:0043492) -4.930.0TAPBP, TAP2, TAP1
peptide antigen binding (GO:0042605) -6.180.008TAPBP, TAP1
hydrolase activity, acting on acid anhydrides (GO:0016817) -3.030.006TAPBP, TAP2, TAP1
pyrophosphatase activity (GO:0016462) -3.040.006TAPBP, TAP2, TAP1
transmembrane transporter activity (GO:0022857) -2.820.011TAPBP, TAP2, TAP1
receptor binding (GO:0005102) -2.430.024TAPBP, TAP2, TAP1
P-P-bond-hydrolysis-driven transmembrane transporter activity (GO:0015405) -4.980.0TAPBP, TAP2, TAP1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) 5.193TAPBP, TAP2, TAP1
antigen processing and presentation (GO:0019882) 4.363TAPBP, TAP2, TAP1
antigen processing and presentation of endogenous antigen (GO:0019883) 6.843TAPBP, TAP2, TAP1
antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) 7.093TAPBP, TAP2, TAP1
response to stimulus (GO:0050896) 1.223TAPBP, TAP2, TAP1
transport (GO:0006810) 1.513TAPBP, TAP2, TAP1
amide transport (GO:0042886) 5.193TAPBP, TAP2, TAP1
localization (GO:0051179) 1.43TAPBP, TAP2, TAP1
immune system process (GO:0002376) 2.293TAPBP, TAP2, TAP1
peptide transport (GO:0015833) 5.443TAPBP, TAP2, TAP1
nitrogen compound transport (GO:0071705) 3.543TAPBP, TAP2, TAP1
biological regulation (GO:0065007) 0.393TAPBP, TAP2, TAP1
organic substance transport (GO:0071702) 2.153TAPBP, TAP2, TAP1
antigen processing and presentation of endogenous peptide antigen (GO:0002483) 7.023TAPBP, TAP2, TAP1
antigen processing and presentation of peptide antigen (GO:0048002) 4.563TAPBP, TAP2, TAP1
cellular process (GO:0009987) 0.263TAPBP, TAP2, TAP1
establishment of localization (GO:0051234) 1.483TAPBP, TAP2, TAP1
regulation of biological process (GO:0050789) 0.453TAPBP, TAP2, TAP1
immune response (GO:0006955) 2.863TAPBP, TAP2, TAP1
symbiont intracellular protein transport in host (GO:0030581) 8.122TAP2, TAP1
intracellular transport of viral protein in host cell (GO:0019060) 8.122TAP2, TAP1
protein localization (GO:0008104) 2.362TAP2, TAP1
positive regulation of antigen processing and presentation of peptide antigen via MHC class I (GO:0002591) 7.782TAP2, TAP1
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.152TAP2, TAP1
cellular localization (GO:0051641) 2.322TAP2, TAP1
antigen processing and presentation of exogenous antigen (GO:0019884) 4.592TAP2, TAP1
single-organism process (GO:0044699) 0.482TAP2, TAP1
antigen processing and presentation via MHC class Ib (GO:0002475) 6.962TAP2, TAP1
antigen processing and presentation of exogenous peptide antigen via MHC class Ib (GO:0002477) 7.652TAP2, TAP1
antigen processing and presentation of endogenous peptide antigen via MHC class Ib (GO:0002476) 7.652TAP2, TAP1
positive regulation of antigen processing and presentation (GO:0002579) 6.92TAP2, TAP1
establishment of protein localization (GO:0045184) 2.532TAP2, TAP1
intracellular protein transport (GO:0006886) 3.22TAP2, TAP1
regulation of antigen processing and presentation (GO:0002577) 6.552TAP2, TAP1
antigen processing and presentation of exogenous peptide antigen (GO:0002478) 4.632TAP2, TAP1
intracellular transport of virus (GO:0075733) 5.572TAP2, TAP1
interspecies interaction between organisms (GO:0044419) 3.082TAP2, TAP1
positive regulation of immune system process (GO:0002684) 2.962TAP2, TAP1
regulation of immune system process (GO:0002682) 2.52TAP2, TAP1
positive regulation of biological process (GO:0048518) 1.22TAP2, TAP1
transmembrane transport (GO:0055085) 2.722TAP2, TAP1
macromolecule localization (GO:0033036) 2.342TAP2, TAP1
regulation of antigen processing and presentation of peptide antigen via MHC class I (GO:0002589) 7.532TAP2, TAP1
multi-organism intracellular transport (GO:1902583) 5.572TAP2, TAP1
multi-organism process (GO:0051704) 2.652TAP2, TAP1
positive regulation of antigen processing and presentation of peptide antigen (GO:0002585) 7.432TAP2, TAP1
regulation of antigen processing and presentation of peptide antigen (GO:0002583) 7.092TAP2, TAP1
cytosol to ER transport (GO:0046967) 9.042TAP2, TAP1
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent (GO:0002485) 7.782TAP2, TAP1
single-organism transport (GO:0044765) 2.182TAP2, TAP1
intracellular protein transport in other organism involved in symbiotic interaction (GO:0051708) 8.122TAP2, TAP1
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent (GO:0002481) 7.652TAP2, TAP1
establishment of localization in cell (GO:0051649) 2.472TAP2, TAP1
interaction with host (GO:0051701) 4.862TAP2, TAP1
antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway (GO:0002488) 7.782TAP2, TAP1
antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent (GO:0002489) 7.782TAP2, TAP1
single-organism localization (GO:1902578) 2.092TAP2, TAP1
multi-organism localization (GO:1902579) 5.512TAP2, TAP1
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway (GO:0002484) 7.432TAP2, TAP1
antigen processing and presentation of peptide antigen via MHC class Ib (GO:0002428) 7.532TAP2, TAP1
intracellular transport (GO:0046907) 2.672TAP2, TAP1
multi-organism transport (GO:0044766) 5.512TAP2, TAP1
multi-organism cellular process (GO:0044764) 3.142TAP2, TAP1
transport of virus (GO:0046794) 5.522TAP2, TAP1
adaptive immune response (GO:0002250) 4.432TAP2, TAP1
viral process (GO:0016032) 3.152TAP2, TAP1
protein transport (GO:0015031) 2.622TAP2, TAP1
single-organism intracellular transport (GO:1902582) 3.592TAP2, TAP1
(GO:1902581) 5.572TAP2, TAP1
single-organism cellular localization (GO:1902580) 3.162TAP2, TAP1

NET-GE enrichment

Term New enriched termICP valueGenes
symbiont intracellular protein transport in host (GO:0030581) -8.120.0TAP2, TAP1
intracellular transport of viral protein in host cell (GO:0019060) -8.120.0TAP2, TAP1
peptide transport (GO:0015833) -5.440.0TAPBP, TAP2, TAP1
antigen processing and presentation of peptide antigen (GO:0048002) -4.560.003TAPBP, TAP2, TAP1
antigen processing and presentation via MHC class Ib (GO:0002475) -6.960.0TAP2, TAP1
antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) -5.190.0TAPBP, TAP2, TAP1
amide transport (GO:0042886) -5.190.0TAPBP, TAP2, TAP1
antigen processing and presentation of endogenous peptide antigen via MHC class Ib (GO:0002476) -7.650.0TAP2, TAP1
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:0002479) NEW5.590.0TAPBP, TAP2, TAP1
antigen processing and presentation of exogenous peptide antigen (GO:0002478) -4.630.0TAPBP, TAP2, TAP1
intracellular transport of virus (GO:0075733) -5.570.006TAP2, TAP1
nitrogen compound transport (GO:0071705) -3.540.002TAPBP, TAP2, TAP1
antigen processing and presentation (GO:0019882) -4.360.009TAPBP, TAP2, TAP1
antigen processing and presentation of endogenous antigen (GO:0019883) -6.840.0TAPBP, TAP2, TAP1
antigen processing and presentation of exogenous antigen (GO:0019884) -4.590.003TAPBP, TAP2, TAP1
antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) -7.090.0TAPBP, TAP2, TAP1
antigen processing and presentation of exogenous peptide antigen via MHC class Ib (GO:0002477) -7.650.0TAP2, TAP1
cytosol to ER transport (GO:0046967) -9.040.0TAP2, TAP1
multi-organism transport (GO:0044766) -5.510.006TAP2, TAP1
intracellular protein transport in other organism involved in symbiotic interaction (GO:0051708) -8.120.0TAP2, TAP1
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent (GO:0002481) -7.650.0TAP2, TAP1
antigen processing and presentation of endogenous peptide antigen (GO:0002483) -7.020.0TAPBP, TAP2, TAP1
interaction with host (GO:0051701) -4.860.011TAP2, TAP1
antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway (GO:0002488) -7.780.0TAP2, TAP1
antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent (GO:0002489) -7.780.0TAP2, TAP1
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway (GO:0002484) -7.430.0TAP2, TAP1
antigen processing and presentation of peptide antigen via MHC class Ib (GO:0002428) -7.530.0TAP2, TAP1
intracellular transport (GO:0046907) -2.670.044TAPBP, TAP2, TAP1
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent (GO:0002485) -7.780.0TAP2, TAP1
antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) NEW5.540.0TAPBP, TAP2, TAP1
transport of virus (GO:0046794) -5.520.006TAP2, TAP1
multi-organism intracellular transport (GO:1902583) -5.570.001TAP2, TAP1
single-organism intracellular transport (GO:1902582) -3.590.021TAPBP, TAP2, TAP1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
endoplasmic reticulum (GO:0005783) 2.563TAPBP, TAP2, TAP1
endoplasmic reticulum membrane (GO:0005789) 2.953TAPBP, TAP2, TAP1
intracellular organelle (GO:0043229) 0.513TAPBP, TAP2, TAP1
integral component of endoplasmic reticulum membrane (GO:0030176) 5.013TAPBP, TAP2, TAP1
membrane-bounded organelle (GO:0043227) 0.473TAPBP, TAP2, TAP1
organelle (GO:0043226) 0.43TAPBP, TAP2, TAP1
intrinsic component of membrane (GO:0031224) 1.133TAPBP, TAP2, TAP1
integral component of membrane (GO:0016021) 1.143TAPBP, TAP2, TAP1
membrane (GO:0016020) 0.683TAPBP, TAP2, TAP1
intrinsic component of endoplasmic reticulum membrane (GO:0031227) 4.973TAPBP, TAP2, TAP1
endoplasmic reticulum part (GO:0044432) 2.733TAPBP, TAP2, TAP1
TAP complex (GO:0042825) 8.423TAPBP, TAP2, TAP1
protein complex (GO:0043234) 1.513TAPBP, TAP2, TAP1
macromolecular complex (GO:0032991) 1.353TAPBP, TAP2, TAP1
intracellular membrane-bounded organelle (GO:0043231) 0.63TAPBP, TAP2, TAP1
cell part (GO:0044464) 0.113TAPBP, TAP2, TAP1
intracellular organelle part (GO:0044446) 0.813TAPBP, TAP2, TAP1
membrane protein complex (GO:0098796) 2.843TAPBP, TAP2, TAP1
cytoplasmic part (GO:0044444) 0.823TAPBP, TAP2, TAP1
intracellular part (GO:0044424) 0.283TAPBP, TAP2, TAP1
membrane part (GO:0044425) 0.953TAPBP, TAP2, TAP1
organelle part (GO:0044422) 0.793TAPBP, TAP2, TAP1
other organism part (GO:0044217) 6.972TAP2, TAP1
host cell (GO:0043657) 8.192TAP2, TAP1
other organism cell (GO:0044216) 7.722TAP2, TAP1

NET-GE enrichment

Term New enriched termICP valueGenes
bounding membrane of organelle (GO:0098588) NEW2.390.035TAPBP, TAP2, TAP1
membrane region (GO:0098589) NEW3.950.01TAPBP, TAP2, TAP1
endoplasmic reticulum membrane (GO:0005789) -2.950.044TAPBP, TAP2, TAP1
endoplasmic reticulum part (GO:0044432) -2.730.005TAPBP, TAP2, TAP1
integral component of endoplasmic reticulum membrane (GO:0030176) -5.010.0TAPBP, TAP2, TAP1
integral component of organelle membrane (GO:0031301) NEW4.850.001TAPBP, TAP2, TAP1
TAP complex (GO:0042825) -8.420.0TAP2, TAP1