Disease table of OSTEOGENIC SARCOMA OMIM ID: 259500

Gene-disease associations table

GeneAssociated with OSTEOGENIC SARCOMA inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
TP53ClinVar, OMIMHGNC link17p13.112114550, 260500, 605027, PS137800, 614740, 114480, 260350, 607107, 202300, 114500, PS151623, 259500
CHEK2ClinVar, OMIMHGNC link22q12.14PS151623, 176807, 259500, 114480
RB1OMIMHGNC link13q14.24109800, 180200, 259500, 182280

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
TP53YES159ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING13CHEK2, RB1, TP53
RB1YES29CDK1, DDIT3, BIRC5, MAP3K5, EBNA1BP2, DNMT3A, FOS, SFTPD, SP1, DHFR, HBP1, BRCA1, CDKN1A, RBL1, TFDP1, CDH1, ATF2, PCNA, E2F2, ELF1, E2F1, WRN, FGFR1, TP53BP2, RB1, IGF1, MYC, PPARG, E2F31RB1
YY1NO74FCER1A, CFTR, EGFR, GDAP1, POSTN, TP53, ATP2C1, IFNG, ADORA2A, KIR3DL1, TOP3A, HBE1, LDLR, SERPINE1, LRIG2, HSPA5, GBP1, HLA-DRA, APC, HAS2, CCL13, SNRPN, FMO3, TFRC, CTCF, FAS, TF, CXCR4, FCGR3B, DNAJB4, HSD3B2, ERBB2, SURF1, TDO2, IVL, BRCA1, DEK, COX7C, CETP, ERCC5, NOS2, BDKRB1, SLC26A3, EPAS1, ACTC1, ZNF175, BAP1, TNFRSF10B, HOXB7, NF1, OPRM1, PCNA, PARP1, PRDM2, VWF, TP73, CCR5, CBX5, SURF2, IL4, NR3C1, PDIA6, CYP3A5, CREBBP, HCFC1, IL5, DBH, RB1, FDPS, FCGR2B, LSS, MYC, HOXB13, COL1A22RB1, TP53
BDP1NO3MYC, RB1, TP532RB1, TP53
MYCNO102CBFB, PRDX3, CHKA, ATF3, CDK4, PCNA, CEBPA, LDHA, DKK1, MTDH, TFAP4, HLA-G, CDC25A, UBE2C, HLA-B, GATA1, TP53, BAG2, PMAIP1, CDK6, WRN, PGK1, TFAM, IGK, JUNB, ZFP36, HNRNPA1, MYB, SART3, EBNA1BP2, TOP1MT, ST3GAL4, CD33, CCND2, PTBP1, CDCA7, RB1, CCNA2, HLA-C, CYP3A4, FMR1, TERT, NFE2, MME, NDRG1, HDAC2, BRD7, FASLG, CCNB1, TP73, RCC1, SFRP1, HLA-F, CFLAR, BCAT1, CD38, TFRC, CCND1, MTA1, KRAS, HNRNPA2B1, CDC34, ST3GAL3, HLA-A, FUT3, NOL7, FTH1P18, VEGFA, EP300, CDK2, ASS1, SURF1, CDC25C, IER3, ST3GAL1, FOXM1, HSPA4, XPO1, CAD, SHMT1, DDX18, IGF2BP1, BMI1, IPO7, BCL2, CXCR4, SRSF1, TLX1, PRODH, NBN, CDKN1A, IFNA1, TNFRSF10B, ID2, CCNE1, SURF2, HLA-E, CREBBP, MAPK1, IL6, EIF4E, ODC12RB1, TP53
PAX5NO20XBP1, BAX, FCER2, LEF1, BLK, BCL2, MET, CCND1, RAG2, CDKN1A, TP53, PRDM1, RB1, CD79A, PRKCE, TIMP1, FHL2, MMP1, MYCN, CD192RB1, TP53
E2F1NO123WWOX, DOK1, MEFV, MYBL2, MCM8, FZD1, DIRAS3, PIN1, PCNA, DHFR, ETV4, LRBA, RPA2, FSHR, SERPINB5, PCSK6, TP53, FOXM1, E2F1, IL23A, CD2AP, HMGA1, XRCC1, FHIT, IRF3, ATM, MYC, MT1G, NRIP1, FLT1, RRP1B, MYB, SERPINE1, BMI1, CDKN2A, SKP2, MAPK8, CCNE1, CASP7, CDCA7, HIC1, THBS1, RB1, TNF, IL1B, ULK1, ERCC1, CUX1, TERT, MCL1, AR, KIR3DL1, NPAT, PDK4, DDB2, E2F6, ABCB1, BBC3, AURKA, NOX4, MYCN, CCNB1, TP73, FGFR1, RRM1, RRM2, HSPA5, TLR3, MUC4, CCND1, MCPH1, BRCA1, DRAM1, ERCC5, BIRC5, TYMS, RASGEF1B, MAP1LC3A, VEGFA, RACGAP1, FANCA, UHRF1, CHEK1, MCM5, RASGRP1, APAF1, ISYNA1, ECT2, TNFSF11, AURKB, CDK1, MDM2, DDIT3, MAP3K5, DBF4, PNRC2, KIF2C, POLA1, CTNNBIP1, ELF4, KDR, TP53INP1, ATAD2, CCL3, TK1, ATG5, CDKN1A, SIVA1, PEG10, TOP2A, CDAN1, CHEK2, DUSP1, ASF1B, DAPK2, PTPRO, BCL2, CREBBP, TP53BP2, GINS3, MYH10, PPARG, PPP1R13B3CHEK2, RB1, TP53
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
TP53YES50ATM, RELA, ERCC2, ETS2, ELF4, EZH2, HDAC9, FOS, PAX5, MCM4, RUVBL1, ZBTB2, EGR1, KLF4, MCM2, AATF, PAX2, TFDP1, STAT1, IRF1, PAX8, HIPK2, HDAC1, SIRT1, MDM4, VHL, ESR1, ING1, IFI16, STAT3, JUN, TP53, ABL1, NUPR1, NFKB1, E2F1, ETS1, CREBBP, HOXA10, NR3C1, YY1, NF1, ING4, HMGA1, SOX6, BDP1, MYC, PPARG, PML, MYCN1TP53
CHEK2YES2E2F1, TP531TP53
RB1YES19KAT2B, MYC, UHRF1, BDP1, RB1CC1, YY1, MYF6, RB1, HCFC1, MYOG, ID2, DNMT1, TP53, CTNNB1, MYOD1, DNMT3A, MYF5, E2F1, PAX52RB1, TP53
BRCA1NO33WWP1, RBL2, EZH2, DLX4, CTBP1, SP1, E2F4, ID4, NCOA3, USF2, MTA1, E2F1, FOSL2, RBL1, FOXP3, IFI16, NFE2L2, SP100, TP53, CTCF, EP300, ETS1, E2F6, NR3C1, YY1, JUN, TP53BP1, RB1, HMGA1, ESR1, AHR, CREBBP, FOXA12RB1, TP53
WRNNO5SP1, RB1, MYC, SIRT1, TP532RB1, TP53
CDKN1ANO118ABL1, TFAP4, TP53, MYF5, TCF3, HDAC9, PAX5, ZBTB2, LCOR, E2F3, ZBTB5, HSF1, ELL, TSC22D3, NCOA1, TAF1, RELA, MYOD1, STAT1, PTTG1, KLF16, ESR1, JUNB, MYCN, KAT2B, AR, BCL6, KLF10, EZH2, ARID1A, JUND, SP1, CEBPB, ZFHX3, ZNF300, EGR1, KLF4, AATF, HDAC7, HBP1, SMARCA4, ESR2, FOXP3, RARA, NELFCD, ING4, HDAC4, TBX2, IRF1, HDAC2, ETV6, SIRT2, MYOG, KLF6, TP73, SOX6, ATM, ERCC2, SMAD4, ETS2, NUPR1, PTMA, MLLT10, SMAD3, ETS1, CBX8, BRCA1, HIPK2, SIRT1, WT1, ZNF76, HDAC1, SMAD2, MLLT3, TFAP2A, EP300, FHL2, TP63, IRF9, EHMT2, TFAP2C, NFIX, RUNX3, RB1, HNF4A, NFIB, TAF5, SOX9, TBP, EAPP, ZBTB17, TAF4, REL, RELB, PML, SMAD7, NPM1, POU5F1, E2F1, TBX3, FOXG1, MYF6, NFIA, ATF2, PARP1, NFKB1, STAT3, GFI1, NR3C1, CREBBP, MTA1, JUN, KLF2, CDX2, SP3, MYC, PPARG, ING12RB1, TP53
CDK1NO9PTTG1, IRF1, ETS2, RB1, TFDP1, TP53, E2F1, TP73, E2F32RB1, TP53
MYCNO66E2F4, LEF1, PGR, FOXM1, TBP, FUBP1, TP53, MYBL2, SMAD4, MXI1, MYB, AATF, ZNF382, FOS, ZBTB7A, SP1, E2F5, RBL1, TCF4, TBL1X, EP300, SMAD7, HDAC3, TCF3, SRSF1, SMAD3, CNBP, TLX1, ESR1, SIRT1, WT1, APC, CTNNB1, CEBPE, PRDM1, IFI16, DLX5, HDAC10, ZNF300, JUN, ETS2, RELA, BCL6, NFKB1, BRCA1, E2F1, STAT3, HDAC11, CEBPA, HOXA1, PTTG1, PPARG, YY1, MTA1, HDAC2, NF1, SNIP1, RUNX3, RB1, CTCF, ENO1, BDP1, AHR, STAT4, RFX1, HNF4A2RB1, TP53
BIRC5NO25ILF3, E2F4, TP53, TCF7L2, SP1, TCF4, NFKB1, KLF4, DNMT1, CTNNB1, FOXO3, APC, LEF1, HDAC1, RELA, EP300, E2F1, STAT3, SP4, EHMT2, RB1, SP3, TP73, KLF5, MYCN2RB1, TP53
E2F3NO6KLF5, TP53, BRD7, RB1, TRIM28, HIF1A2RB1, TP53
E2F1NO27KAT2B, EIF2AK2, E2F7, POLR1A, PGR, SP1, NFKB1, YBX1, PAX8, NR2F2, E2F8, SIN3A, TRIM16, NR4A1, TP53, RELA, PARP1, PA2G4, E2F1, E2F6, NR0B2, IRF1, HES1, HCFC1, RB1, ESR1, TP732RB1, TP53
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
TP53CHEK2Yes36ATM, KAT2B, MDC1, VCP, SRPK1, MAPK3, TP53, DAPK3, TP53BP1, RNF20, ATR, MDM2, MSH2, RCHY1, BRCA1, PPP2R5C, SIRT1, VHL, CUL4A, PRKDC, FOXK2, ELAVL1, NR4A1, TRIM28, PPP2R1A, PSME3, FOXK1, UBR5, BRCA2, PLK3, MAPK1, PLK1, RB1, CHEK2, PML, MDM4
TP53RB1Yes77KAT2B, CDK1, RBBP5, RUNX2, TBP, CHEK1, DNAJA2, POLA1, FOXA3, RBBP7, PRDM2, SKI, KAT5, CTBP1, CDK5, BCR, KDM1A, TAF1, MAPK8, FOXO3, UBR4, MDM2, CASP8, TP73, EP300, PML, BRCA1, UHRF2, RFC1, MDM4, FZR1, BRF1, DNMT1, ZBTB7A, LMNA, SNW1, MAPK14, SP1, TFDP1, SIRT1, CCNA2, UBE2I, CDKN1A, TRIM27, VDR, SIN3A, HDAC1, FOXK2, HMGB1, AURKB, TP53, RING1, TOP2A, TFAP2A, ABL1, NPM1, CHEK2, L3MBTL1, PSMD10, MYC, FOXK1, USP7, UHRF1, CDK2, YY1, PHB, HDAC2, PPP1CA, MRPS18B, SMYD2, SMARCA4, RBBP6, MNAT1, RBBP4, GTF2H1, HIF1A, E4F1
CHEK2RB1Yes14KAT2B, FOXM1, PRMT2, PML, FOXK2, TP53, AATF, MDM2, SIRT1, BRCA1, FOS, CHEK2, FOXK1, MDM4

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
TP53CHEK2Yesactivation, binding33KAT2B, PLK3, TREX1, MDM2, CHEK1, CDC25A, TP53BP1, ATR, FOXM1, MSH2, PPM1D, RCHY1, BRCA1, YWHAZ, VHL, CDKN1A, ELAVL1, TOP2A, H2AFX, BRCA2, TP63, WRN, CABIN1, ASF1A, PLK1, KPNA2, RB1, MDM4, SFN, UBC, TP73, PML, CDC25C
TP53RB1Yesactivation, binding87AKT1, TAF1, DNMT3A, PCNA, PRDM2, PAX5, MAPK14, BAX, TFDP1, JUN, CDK4, ABL1, HMGA2, PSMD10, YY1, HMGA1, TERT, KAT2B, AR, RUNX2, CHEK1, ACTL6A, PAX2, ARID1A, SKP2, SP1, KDM1A, TICAM2, SMARCA4, CDH1, SP100, HSP90AA1, TMED7, CABIN1, HDAC2, CCNE2, MDM4, UBC, TP73, E2F4, NFYA, FOS, CCNA2, PHB, CCND1, TBP, SOCS1, RAF1, BRCA1, SIRT1, SMARCB1, STAT3, UBN1, EP300, SMARCD1, CDK2, ASF1A, MNAT1, SMYD2, CDK1, MDM2, MET, CCNA1, RB1CC1, CTBP1, CDK5, PML, PPP2R4, NPM1, CDK9, DNMT1, DNAJA3, HDAC1, CDKN1A, NFYC, ID2, TOP2A, H1F0, CHEK2, DUSP1, NFYB, CREBBP, MAPK1, UHRF2, SP3, MYC, PPARG
CHEK2RB1Yesbinding18KAT2B, MCM4, CDKN1A, MCM5, MDM2, ASF1A, CABIN1, MCM2, CHEK1, MCM3, PPP2CA, PML, TOP2A, TP53, UBC, BRCA1, TP73, MDM4

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
CHEK2RB1No-11HIST1H3E, HIST1H3B, HIST1H3G, HIST1H3J, HIST1H3H, HIST1H3A; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J, HIST1H3F, HIST1H3I, HIST1H3C, HIST1H3A, HIST1H3D

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
CHEK2RB1yes, they interactCHEK2 phosphorylates RB1. [UniProt]
CHEK2TP53yes, they interactTP53 is phosphorylated on Ser-20 by CHEK2 in response to DNA damage. [UniProt]
RB1TP53No
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
HTLV-I infectionhsa051664.593CHEK2, RB1, TP53
Cell cyclehsa041105.683CHEK2, RB1, TP53
Melanomahsa052186.562RB1, TP53
Bladder cancerhsa052197.382RB1, TP53
Pancreatic cancerhsa052126.562RB1, TP53
Pathways in cancerhsa052003.982RB1, TP53
Gliomahsa052146.662RB1, TP53
Prostate cancerhsa052156.112RB1, TP53
Non-small cell lung cancerhsa052236.882RB1, TP53
Epstein-Barr virus infectionhsa051694.972RB1, TP53
Chronic myeloid leukemiahsa052206.482RB1, TP53
Viral carcinogenesishsa052035.082RB1, TP53
p53 signaling pathwayhsa041156.562CHEK2, TP53
Hepatitis Bhsa051615.522RB1, TP53
Small cell lung cancerhsa052226.172RB1, TP53

NET-GE enrichment

Term New enriched termICP valueGenes
Signaling pathways regulating pluripotency of stem cells (hsa04550) NEW5.60.007CHEK2, RB1, TP53
Bladder cancer (hsa05219) -7.380.021RB1, TP53
Pancreatic cancer (hsa05212) -6.560.016RB1, TP53
Cell cycle (hsa04110) -5.680.0CHEK2, RB1, TP53
Melanoma (hsa05218) -6.560.016RB1, TP53
Glioma (hsa05214) -6.660.014RB1, TP53
Prostate cancer (hsa05215) -6.110.029RB1, TP53
Non-small cell lung cancer (hsa05223) -6.880.01RB1, TP53
Small cell lung cancer (hsa05222) -6.170.027RB1, TP53
Chronic myeloid leukemia (hsa05220) -6.480.017RB1, TP53
HTLV-I infection (hsa05166) -4.590.003CHEK2, RB1, TP53
p53 signaling pathway (hsa04115) -6.560.016CHEK2, TP53
Cell growth and deathNEW4.410.005CHEK2, RB1, TP53
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Cell CycleR-HSA-16401703.893CHEK2, RB1, TP53
Formation of Senescence-Associated Heterochromatin Foci (SAHF)R-HSA-25595848.982RB1, TP53
DNA Damage/Telomere Stress Induced SenescenceR-HSA-25595867.152RB1, TP53
Cellular SenescenceR-HSA-25595835.72RB1, TP53
Cellular responses to stressR-HSA-22627524.562RB1, TP53
Cell Cycle CheckpointsR-HSA-696205.642CHEK2, TP53
G1/S DNA Damage CheckpointsR-HSA-696157.082CHEK2, TP53

NET-GE enrichment

Term New enriched termICP valueGenes
Formation of Senescence-Associated Heterochromatin Foci (SAHF) (R-HSA-2559584) -8.980.005RB1, TP53
Reproduction (R-HSA-1474165) NEW8.280.027RB1, TP53
RNA Polymerase III Abortive And Retractive Initiation (R-HSA-749476) NEW7.660.021RB1, TP53
DNA Damage/Telomere Stress Induced Senescence (R-HSA-2559586) -7.150.008RB1, TP53
G1/S DNA Damage Checkpoints (R-HSA-69615) -7.080.009CHEK2, TP53
G1 Phase (R-HSA-69236) NEW7.730.022RB1, TP53
Fertilization (R-HSA-1187000) NEW8.280.027RB1, TP53
Cyclin D associated events in G1 (R-HSA-69231) NEW7.730.022RB1, TP53
Cell Cycle (R-HSA-1640170) -3.890.018CHEK2, RB1, TP53
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (R-HSA-2173793) NEW7.560.048RB1, TP53
RNA Polymerase III Transcription (R-HSA-74158) NEW7.660.021RB1, TP53
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (R-HSA-2173796) NEW8.030.024RB1, TP53
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
ubiquitin protein ligase binding (GO:0031625) 4.173CHEK2, RB1, TP53
ubiquitin-like protein ligase binding (GO:0044389) 4.153CHEK2, RB1, TP53
organic cyclic compound binding (GO:0097159) 1.053CHEK2, RB1, TP53
enzyme binding (GO:0019899) 2.273CHEK2, RB1, TP53
kinase binding (GO:0019900) 3.323CHEK2, RB1, TP53
binding (GO:0005488) 0.183CHEK2, RB1, TP53
protein binding (GO:0005515) 0.463CHEK2, RB1, TP53
heterocyclic compound binding (GO:1901363) 1.063CHEK2, RB1, TP53
identical protein binding (GO:0042802) 2.633CHEK2, RB1, TP53
purine ribonucleoside triphosphate binding (GO:0035639) 2.222CHEK2, TP53
nucleic acid binding transcription factor activity (GO:0001071) 2.652RB1, TP53
nucleic acid binding (GO:0003676) 1.442RB1, TP53
DNA binding (GO:0003677) 1.922RB1, TP53
ion binding (GO:0043167) 1.362CHEK2, TP53
purine nucleoside binding (GO:0001883) 2.222CHEK2, TP53
nucleoside binding (GO:0001882) 2.212CHEK2, TP53
cation binding (GO:0043169) 1.42CHEK2, TP53
nucleotide binding (GO:0000166) 1.962CHEK2, TP53
nucleoside phosphate binding (GO:1901265) 1.962CHEK2, TP53
ribonucleoside binding (GO:0032549) 2.222CHEK2, TP53
purine nucleotide binding (GO:0017076) 2.192CHEK2, TP53
metal ion binding (GO:0046872) 1.412CHEK2, TP53
ATP binding (GO:0005524) 2.432CHEK2, TP53
transcription factor binding (GO:0008134) 3.462RB1, TP53
regulatory region nucleic acid binding (GO:0001067) 3.032RB1, TP53
small molecule binding (GO:0036094) 1.892CHEK2, TP53
core promoter binding (GO:0001047) 4.712RB1, TP53
receptor binding (GO:0005102) 2.432RB1, TP53
RNA polymerase II transcription factor binding (GO:0001085) 5.082RB1, TP53
transcription regulatory region DNA binding (GO:0044212) 3.032RB1, TP53
adenyl nucleotide binding (GO:0030554) 2.42CHEK2, TP53
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.652RB1, TP53
carbohydrate derivative binding (GO:0097367) 2.032CHEK2, TP53
adenyl ribonucleotide binding (GO:0032559) 2.412CHEK2, TP53
ribonucleotide binding (GO:0032553) 2.192CHEK2, TP53
regulatory region DNA binding (GO:0000975) 3.032RB1, TP53
purine ribonucleotide binding (GO:0032555) 2.22CHEK2, TP53
protein dimerization activity (GO:0046983) 2.722CHEK2, TP53
purine ribonucleoside binding (GO:0032550) 2.222CHEK2, TP53
protein kinase binding (GO:0019901) 3.442CHEK2, TP53

NET-GE enrichment

Term New enriched termICP valueGenes
histone-lysine N-methyltransferase activity (GO:0018024) NEW5.930.02RB1, TP53
histone methyltransferase activity (GO:0042054) NEW5.680.033RB1, TP53
small conjugating protein ligase binding (GO:0044389) -4.150.004CHEK2, RB1, TP53
RNA polymerase II activating transcription factor binding (GO:0001102) NEW6.130.023RB1, TP53
activating transcription factor binding (GO:0033613) NEW5.680.044RB1, TP53
RNA polymerase II regulatory region DNA binding (GO:0001012) NEW3.360.042CHEK2, RB1, TP53
carbohydrate binding (GO:0030246) NEW4.170.028CHEK2, RB1, TP53
lysine N-methyltransferase activity (GO:0016278) NEW5.70.031RB1, TP53
protein-lysine N-methyltransferase activity (GO:0016279) NEW5.710.031RB1, TP53
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001077) NEW4.310.007CHEK2, RB1, TP53
structure-specific DNA binding (GO:0043566) NEW4.980.022CHEK2, RB1, TP53
ligase activity (GO:0016874) NEW3.720.041CHEK2, RB1, TP53
transcription corepressor activity (GO:0003714) NEW4.330.017CHEK2, RB1, TP53
transcription coactivator activity (GO:0003713) NEW4.040.036CHEK2, RB1, TP53
core promoter proximal region sequence-specific DNA binding (GO:0000987) NEW3.830.01CHEK2, RB1, TP53
core promoter proximal region DNA binding (GO:0001159) NEW3.820.01CHEK2, RB1, TP53
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity (GO:0000982) NEW3.940.017CHEK2, RB1, TP53
identical protein binding (GO:0042802) -2.630.018CHEK2, RB1, TP53
kinase binding (GO:0019900) -3.320.002CHEK2, RB1, TP53
cofactor binding (GO:0048037) NEW4.160.025CHEK2, RB1, TP53
enzyme binding (GO:0019899) -2.270.039CHEK2, RB1, TP53
core promoter binding (GO:0001047) -4.710.009RB1, TP53
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001205) NEW6.480.014RB1, TP53
enhancer sequence-specific DNA binding (GO:0001158) NEW5.360.0CHEK2, RB1, TP53
ubiquitin-protein transferase activity (GO:0004842) NEW3.730.011CHEK2, RB1, TP53
RNA polymerase II transcription factor binding (GO:0001085) -5.080.007CHEK2, RB1, TP53
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription (GO:0001227) NEW4.610.001CHEK2, RB1, TP53
ubiquitin protein ligase binding (GO:0031625) -4.170.004CHEK2, RB1, TP53
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (GO:0016811) NEW5.280.049RB1, TP53
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001228) NEW3.980.016CHEK2, RB1, TP53
glycosaminoglycan binding (GO:0005539) NEW4.420.015CHEK2, RB1, TP53
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) NEW3.370.041CHEK2, RB1, TP53
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978) NEW3.880.009CHEK2, RB1, TP53
p53 binding (GO:0002039) NEW5.530.036RB1, TP53
enhancer binding (GO:0035326) NEW5.210.001CHEK2, RB1, TP53
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of phosphate metabolic process (GO:0019220) 2.353CHEK2, RB1, TP53
regulation of primary metabolic process (GO:0080090) 1.083CHEK2, RB1, TP53
regulation of metabolic process (GO:0019222) 1.023CHEK2, RB1, TP53
regulation of response to stimulus (GO:0048583) 1.543CHEK2, RB1, TP53
signal transduction (GO:0007165) 1.283CHEK2, RB1, TP53
organic cyclic compound biosynthetic process (GO:1901362) 1.663CHEK2, RB1, TP53
organic cyclic compound metabolic process (GO:1901360) 1.263CHEK2, RB1, TP53
cellular response to stimulus (GO:0051716) 1.973CHEK2, RB1, TP53
negative regulation of cell cycle (GO:0045786) 3.673CHEK2, RB1, TP53
positive regulation of cell cycle (GO:0045787) 3.943CHEK2, RB1, TP53
regulation of signal transduction (GO:0009966) 1.843CHEK2, RB1, TP53
cellular developmental process (GO:0048869) 1.823CHEK2, RB1, TP53
positive regulation of biological process (GO:0048518) 1.23CHEK2, RB1, TP53
negative regulation of biological process (GO:0048519) 1.333CHEK2, RB1, TP53
regulation of macromolecule metabolic process (GO:0060255) 1.083CHEK2, RB1, TP53
regulation of RNA biosynthetic process (GO:2001141) 1.553CHEK2, RB1, TP53
heterocycle metabolic process (GO:0046483) 1.313CHEK2, RB1, TP53
regulation of phosphorylation (GO:0042325) 2.53CHEK2, RB1, TP53
aromatic compound biosynthetic process (GO:0019438) 1.73CHEK2, RB1, TP53
negative regulation of metabolic process (GO:0009892) 1.933CHEK2, RB1, TP53
positive regulation of metabolic process (GO:0009893) 1.743CHEK2, RB1, TP53
negative regulation of biosynthetic process (GO:0009890) 2.473CHEK2, RB1, TP53
positive regulation of biosynthetic process (GO:0009891) 2.293CHEK2, RB1, TP53
positive regulation of gene expression (GO:0010628) 2.353CHEK2, RB1, TP53
intracellular signal transduction (GO:0035556) 2.393CHEK2, RB1, TP53
macromolecule metabolic process (GO:0043170) 0.833CHEK2, RB1, TP53
regulation of biological process (GO:0050789) 0.453CHEK2, RB1, TP53
nucleic acid-templated transcription (GO:0097659) 1.913CHEK2, RB1, TP53
positive regulation of cell cycle process (GO:0090068) 4.253CHEK2, RB1, TP53
regulation of mitotic cell cycle (GO:0007346) 3.713CHEK2, RB1, TP53
cellular macromolecule metabolic process (GO:0044260) 0.933CHEK2, RB1, TP53
cellular component organization (GO:0016043) 1.243CHEK2, RB1, TP53
biological regulation (GO:0065007) 0.393CHEK2, RB1, TP53
cellular component organization or biogenesis (GO:0071840) 1.223CHEK2, RB1, TP53
heterocycle biosynthetic process (GO:0018130) 1.73CHEK2, RB1, TP53
regulation of biosynthetic process (GO:0009889) 1.373CHEK2, RB1, TP53
regulation of cellular process (GO:0050794) 0.53CHEK2, RB1, TP53
programmed cell death (GO:0012501) 3.13CHEK2, RB1, TP53
metabolic process (GO:0008152) 0.583CHEK2, RB1, TP53
nucleobase-containing compound biosynthetic process (GO:0034654) 1.723CHEK2, RB1, TP53
negative regulation of G1/S transition of mitotic cell cycle (GO:2000134) 5.173CHEK2, RB1, TP53
negative regulation of cell cycle phase transition (GO:1901988) 4.743CHEK2, RB1, TP53
positive regulation of macromolecule metabolic process (GO:0010604) 1.813CHEK2, RB1, TP53
RNA metabolic process (GO:0016070) 1.593CHEK2, RB1, TP53
single-organism developmental process (GO:0044767) 1.493CHEK2, RB1, TP53
cellular nitrogen compound biosynthetic process (GO:0044271) 1.593CHEK2, RB1, TP53
regulation of cell cycle phase transition (GO:1901987) 4.153CHEK2, RB1, TP53
response to stimulus (GO:0050896) 1.223CHEK2, RB1, TP53
regulation of transcription, DNA-templated (GO:0006355) 1.563CHEK2, RB1, TP53
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.393CHEK2, RB1, TP53
regulation of macromolecule biosynthetic process (GO:0010556) 1.433CHEK2, RB1, TP53
transcription, DNA-templated (GO:0006351) 1.913CHEK2, RB1, TP53
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.533CHEK2, RB1, TP53
RNA biosynthetic process (GO:0032774) 1.843CHEK2, RB1, TP53
regulation of protein metabolic process (GO:0051246) 1.933CHEK2, RB1, TP53
cellular biosynthetic process (GO:0044249) 1.373CHEK2, RB1, TP53
cellular nitrogen compound metabolic process (GO:0034641) 1.223CHEK2, RB1, TP53
negative regulation of mitotic cell cycle phase transition (GO:1901991) 4.823CHEK2, RB1, TP53
regulation of mitotic cell cycle phase transition (GO:1901990) 4.233CHEK2, RB1, TP53
cellular response to chemical stimulus (GO:0070887) 2.573CHEK2, RB1, TP53
regulation of signaling (GO:0023051) 1.723CHEK2, RB1, TP53
regulation of cell communication (GO:0010646) 1.733CHEK2, RB1, TP53
single-organism process (GO:0044699) 0.483CHEK2, RB1, TP53
nucleobase-containing compound metabolic process (GO:0006139) 1.353CHEK2, RB1, TP53
regulation of cell cycle process (GO:0010564) 3.53CHEK2, RB1, TP53
regulation of protein modification process (GO:0031399) 2.323CHEK2, RB1, TP53
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.563CHEK2, RB1, TP53
cellular process (GO:0009987) 0.263CHEK2, RB1, TP53
cellular aromatic compound metabolic process (GO:0006725) 1.33CHEK2, RB1, TP53
regulation of nucleic acid-templated transcription (GO:1903506) 1.553CHEK2, RB1, TP53
cellular macromolecule biosynthetic process (GO:0034645) 1.663CHEK2, RB1, TP53
positive regulation of transcription, DNA-templated (GO:0045893) 2.563CHEK2, RB1, TP53
cell cycle (GO:0007049) 3.143CHEK2, RB1, TP53
regulation of cellular protein metabolic process (GO:0032268) 1.993CHEK2, RB1, TP53
regulation of G1/S transition of mitotic cell cycle (GO:2000045) 4.813CHEK2, RB1, TP53
regulation of RNA metabolic process (GO:0051252) 1.523CHEK2, RB1, TP53
positive regulation of RNA metabolic process (GO:0051254) 2.513CHEK2, RB1, TP53
negative regulation of macromolecule metabolic process (GO:0010605) 2.013CHEK2, RB1, TP53
positive regulation of RNA biosynthetic process (GO:1902680) 2.543CHEK2, RB1, TP53
nitrogen compound metabolic process (GO:0006807) 1.133CHEK2, RB1, TP53
developmental process (GO:0032502) 1.363CHEK2, RB1, TP53
positive regulation of cellular biosynthetic process (GO:0031328) 2.33CHEK2, RB1, TP53
negative regulation of cellular biosynthetic process (GO:0031327) 2.493CHEK2, RB1, TP53
regulation of cellular biosynthetic process (GO:0031326) 1.383CHEK2, RB1, TP53
positive regulation of cellular metabolic process (GO:0031325) 1.813CHEK2, RB1, TP53
negative regulation of cellular metabolic process (GO:0031324) 2.013CHEK2, RB1, TP53
regulation of cellular metabolic process (GO:0031323) 1.073CHEK2, RB1, TP53
mitotic cell cycle process (GO:1903047) 3.123CHEK2, RB1, TP53
nucleic acid metabolic process (GO:0090304) 1.463CHEK2, RB1, TP53
negative regulation of cell cycle process (GO:0010948) 4.373CHEK2, RB1, TP53
cell cycle process (GO:0022402) 2.753CHEK2, RB1, TP53
cell death (GO:0008219) 3.053CHEK2, RB1, TP53
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.463CHEK2, RB1, TP53
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.63CHEK2, RB1, TP53
organic substance metabolic process (GO:0071704) 0.633CHEK2, RB1, TP53
regulation of gene expression (GO:0010468) 1.373CHEK2, RB1, TP53
negative regulation of mitotic cell cycle (GO:0045930) 4.453CHEK2, RB1, TP53
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.353CHEK2, RB1, TP53
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.553CHEK2, RB1, TP53
organic substance biosynthetic process (GO:1901576) 1.343CHEK2, RB1, TP53
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433CHEK2, RB1, TP53
apoptotic process (GO:0006915) 3.143CHEK2, RB1, TP53
regulation of phosphorus metabolic process (GO:0051174) 2.353CHEK2, RB1, TP53
biosynthetic process (GO:0009058) 1.323CHEK2, RB1, TP53
macromolecule biosynthetic process (GO:0009059) 1.613CHEK2, RB1, TP53
single-organism cellular process (GO:0044763) 0.653CHEK2, RB1, TP53
regulation of nitrogen compound metabolic process (GO:0051171) 1.363CHEK2, RB1, TP53
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.473CHEK2, RB1, TP53
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.293CHEK2, RB1, TP53
response to chemical (GO:0042221) 1.983CHEK2, RB1, TP53
primary metabolic process (GO:0044238) 0.693CHEK2, RB1, TP53
cell cycle checkpoint (GO:0000075) 4.793CHEK2, RB1, TP53
regulation of cell cycle (GO:0051726) 2.933CHEK2, RB1, TP53
cellular metabolic process (GO:0044237) 0.693CHEK2, RB1, TP53
regulation of cell cycle G1/S phase transition (GO:1902806) 4.743CHEK2, RB1, TP53
negative regulation of cell cycle G1/S phase transition (GO:1902807) 5.143CHEK2, RB1, TP53
regulation of protein phosphorylation (GO:0001932) 2.573CHEK2, RB1, TP53
negative regulation of cellular process (GO:0048523) 1.413CHEK2, RB1, TP53
positive regulation of cellular process (GO:0048522) 1.33CHEK2, RB1, TP53
protein localization (GO:0008104) 2.362RB1, TP53
negative regulation of response to stimulus (GO:0048585) 2.522CHEK2, RB1
signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) 5.592CHEK2, TP53
signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) 5.592CHEK2, TP53
intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) 5.592CHEK2, TP53
positive regulation of apoptotic process (GO:0043065) 3.382CHEK2, TP53
signal transduction involved in DNA damage checkpoint (GO:0072422) 5.552CHEK2, TP53
peptidyl-amino acid modification (GO:0018193) 2.982CHEK2, TP53
interspecies interaction between organisms (GO:0044419) 3.082RB1, TP53
negative regulation of molecular function (GO:0044092) 2.742RB1, TP53
regulation of signal transduction by p53 class mediator (GO:1901796) 4.632CHEK2, TP53
macromolecule localization (GO:0033036) 2.342RB1, TP53
regulation of cell proliferation (GO:0042127) 2.412RB1, TP53
negative regulation of DNA metabolic process (GO:0051053) 4.982CHEK2, TP53
regulation of DNA metabolic process (GO:0051052) 3.872CHEK2, TP53
glial cell apoptotic process (GO:0034349) 7.652RB1, TP53
DNA repair (GO:0006281) 3.592CHEK2, TP53
protein catabolic process (GO:0030163) 3.932CHEK2, TP53
signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) 5.592CHEK2, TP53
multi-organism process (GO:0051704) 2.652RB1, TP53
cellular catabolic process (GO:0044248) 2.622CHEK2, TP53
positive regulation of phosphorylation (GO:0042327) 2.92CHEK2, TP53
protein metabolic process (GO:0019538) 1.452CHEK2, TP53
positive regulation of organelle organization (GO:0010638) 3.382RB1, TP53
cellular response to stress (GO:0033554) 2.512CHEK2, TP53
cellular component assembly (GO:0022607) 2.142CHEK2, TP53
negative regulation of gene expression (GO:0010629) 2.482RB1, TP53
signal transduction by p53 class mediator (GO:0072331) 4.882CHEK2, TP53
signal transduction involved in DNA integrity checkpoint (GO:0072401) 5.552CHEK2, TP53
cellular protein metabolic process (GO:0044267) 1.632CHEK2, TP53
organic substance catabolic process (GO:1901575) 2.452CHEK2, TP53
cellular macromolecule catabolic process (GO:0044265) 3.192CHEK2, TP53
DNA integrity checkpoint (GO:0031570) 5.252CHEK2, TP53
negative regulation of transferase activity (GO:0051348) 3.872RB1, TP53
regulation of molecular function (GO:0065009) 1.782RB1, TP53
regulation of biological quality (GO:0065008) 1.682CHEK2, TP53
positive regulation of cellular component organization (GO:0051130) 2.682RB1, TP53
regulation of catalytic activity (GO:0050790) 1.972RB1, TP53
cell cycle arrest (GO:0007050) 4.692RB1, TP53
response to stress (GO:0006950) 1.82CHEK2, TP53
protein modification process (GO:0036211) 1.792CHEK2, TP53
intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630) 5.442CHEK2, TP53
regulation of intracellular signal transduction (GO:1902531) 2.312CHEK2, TP53
positive regulation of protein modification process (GO:0031401) 2.72CHEK2, TP53
macromolecule modification (GO:0043412) 1.732CHEK2, TP53
regulation of transferase activity (GO:0051338) 2.882RB1, TP53
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242RB1, TP53
positive regulation of chromosome organization (GO:2001252) 4.762RB1, TP53
positive regulation of phosphorus metabolic process (GO:0010562) 2.782CHEK2, TP53
regulation of chromosome organization (GO:0033044) 4.112RB1, TP53
regulation of organelle organization (GO:0033043) 2.722RB1, TP53
response to radiation (GO:0009314) 3.692CHEK2, TP53
cell differentiation (GO:0030154) 2.142RB1, TP53
regulation of cellular component organization (GO:0051128) 2.012RB1, TP53
regulation of cellular protein localization (GO:1903827) 3.432RB1, TP53
negative regulation of catalytic activity (GO:0043086) 3.02RB1, TP53
regulation of protein localization (GO:0032880) 2.882RB1, TP53
response to ionizing radiation (GO:0010212) 4.742CHEK2, TP53
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122RB1, TP53
signal transduction involved in cell cycle checkpoint (GO:0072395) 5.542CHEK2, TP53
positive regulation of protein metabolic process (GO:0051247) 2.432CHEK2, TP53
macromolecule catabolic process (GO:0009057) 3.02CHEK2, TP53
positive regulation of cellular protein metabolic process (GO:0032270) 2.492CHEK2, TP53
negative regulation of cell proliferation (GO:0008285) 3.262RB1, TP53
cellular macromolecule localization (GO:0070727) 3.12RB1, TP53
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712RB1, TP53
cellular response to DNA damage stimulus (GO:0006974) 3.172CHEK2, TP53
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:0006977) 5.62CHEK2, TP53
negative regulation of transcription, DNA-templated (GO:0045892) 2.752RB1, TP53
regulation of localization (GO:0032879) 1.942RB1, TP53
aging (GO:0007568) 4.162CHEK2, TP53
cell aging (GO:0007569) 5.542CHEK2, TP53
negative regulation of RNA metabolic process (GO:0051253) 2.662RB1, TP53
response to drug (GO:0042493) 3.712CHEK2, TP53
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.812RB1, TP53
regulation of cellular localization (GO:0060341) 3.032RB1, TP53
macromolecular complex subunit organization (GO:0043933) 2.142RB1, TP53
apoptotic signaling pathway (GO:0097190) 4.122CHEK2, TP53
intrinsic apoptotic signaling pathway (GO:0097193) 4.692CHEK2, TP53
cell cycle phase transition (GO:0044770) 4.242CHEK2, RB1
mitotic cell cycle phase transition (GO:0044772) 4.272CHEK2, RB1
cellular response to drug (GO:0035690) 5.482CHEK2, TP53
positive regulation of cell death (GO:0010942) 3.322CHEK2, TP53
regulation of cell death (GO:0010941) 2.432CHEK2, TP53
cell division (GO:0051301) 3.682CHEK2, RB1
chromatin organization (GO:0006325) 3.282RB1, TP53
regulation of apoptotic process (GO:0042981) 2.52CHEK2, TP53
response to gamma radiation (GO:0010332) 5.782CHEK2, TP53
positive regulation of cell cycle arrest (GO:0071158) 5.292CHEK2, TP53
regulation of programmed cell death (GO:0043067) 2.492CHEK2, TP53
positive regulation of programmed cell death (GO:0043068) 3.382CHEK2, TP53
regulation of cell cycle arrest (GO:0071156) 5.052CHEK2, TP53
positive regulation of phosphate metabolic process (GO:0045937) 2.782CHEK2, TP53
DNA damage response, signal transduction by p53 class mediator (GO:0030330) 5.32CHEK2, TP53
cellular protein localization (GO:0034613) 3.112RB1, TP53
cellular protein modification process (GO:0006464) 1.792CHEK2, TP53
negative regulation of RNA biosynthetic process (GO:1902679) 2.72RB1, TP53
multi-organism cellular process (GO:0044764) 3.142RB1, TP53
Ras protein signal transduction (GO:0007265) 4.762RB1, TP53
small GTPase mediated signal transduction (GO:0007264) 3.852RB1, TP53
catabolic process (GO:0009056) 2.382CHEK2, TP53
localization (GO:0051179) 1.42RB1, TP53
signal transduction in response to DNA damage (GO:0042770) 5.152CHEK2, TP53
cellular localization (GO:0051641) 2.322RB1, TP53
organelle organization (GO:0006996) 2.022CHEK2, TP53
response to abiotic stimulus (GO:0009628) 2.82CHEK2, TP53
DNA damage checkpoint (GO:0000077) 5.372CHEK2, TP53
signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) 5.592CHEK2, TP53
replicative senescence (GO:0090399) 7.242CHEK2, TP53
anatomical structure development (GO:0048856) 1.582RB1, TP53
regulation of cellular component biogenesis (GO:0044087) 3.082RB1, TP53
single-organism organelle organization (GO:1902589) 2.682CHEK2, TP53
viral process (GO:0016032) 3.152RB1, TP53
DNA metabolic process (GO:0006259) 3.092CHEK2, TP53
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.152RB1, TP53
positive regulation of protein phosphorylation (GO:0001934) 2.952CHEK2, TP53
mitotic cell cycle checkpoint (GO:0007093) 5.312RB1, TP53

NET-GE enrichment

Term New enriched termICP valueGenes
G2/M transition of mitotic cell cycle (GO:0000086) NEW4.840.006CHEK2, RB1, TP53
protein acetylation (GO:0006473) NEW4.860.007CHEK2, RB1, TP53
dorsal spinal cord development (GO:0021516) NEW7.780.005CHEK2, TP53
internal protein amino acid acetylation (GO:0006475) NEW4.990.005CHEK2, RB1, TP53
cell maturation (GO:0048469) NEW4.980.03CHEK2, RB1, TP53
female gonad development (GO:0008585) NEW6.640.047CHEK2, TP53
signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) -5.590.025CHEK2, TP53
signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) -5.590.025CHEK2, TP53
reproduction (GO:0000003) NEW7.160.0CHEK2, RB1, TP53
signal transduction involved in DNA damage checkpoint (GO:0072422) -5.550.025CHEK2, TP53
kidney development (GO:0001822) NEW4.790.033CHEK2, RB1, TP53
Ras protein signal transduction (GO:0007265) -4.760.028CHEK2, RB1, TP53
regulation of epithelial cell differentiation (GO:0030856) NEW4.960.027CHEK2, RB1, TP53
negative regulation of DNA metabolic process (GO:0051053) -4.980.003CHEK2, RB1, TP53
histone H3 acetylation (GO:0043966) NEW5.920.0CHEK2, RB1, TP53
trophoblast giant cell differentiation (GO:0060707) NEW7.240.025RB1, TP53
intracellular steroid hormone receptor signaling pathway (GO:0030518) NEW5.470.001CHEK2, RB1, TP53
signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) -5.590.025CHEK2, TP53
cell aging (GO:0007569) -5.540.021CHEK2, RB1, TP53
peptidyl-lysine modification (GO:0018205) NEW3.980.022CHEK2, RB1, TP53
regulation of DNA replication (GO:0006275) NEW5.020.015CHEK2, RB1, TP53
regulation of nuclear division (GO:0051783) NEW4.670.027CHEK2, RB1, TP53
negative regulation of cell division (GO:0051782) NEW7.020.011RB1, TP53
odontogenesis of dentin-containing tooth (GO:0042475) NEW5.520.004CHEK2, RB1, TP53
skeletal system morphogenesis (GO:0048705) NEW4.980.016CHEK2, RB1, TP53
cell differentiation in hindbrain (GO:0021533) NEW6.640.0CHEK2, RB1, TP53
embryonic organ development (GO:0048568) NEW4.860.027CHEK2, RB1, TP53
neuron migration (GO:0001764) NEW5.00.048CHEK2, RB1, TP53
signal transduction involved in DNA integrity checkpoint (GO:0072401) -5.550.025CHEK2, TP53
protein acylation (GO:0043543) NEW4.650.018CHEK2, RB1, TP53
detection of temperature stimulus (GO:0016048) NEW6.90.022CHEK2, TP53
DNA integrity checkpoint (GO:0031570) -5.250.003CHEK2, RB1, TP53
neuron death (GO:0070997) NEW5.860.011RB1, TP53
blood vessel development (GO:0001568) NEW4.950.012CHEK2, RB1, TP53
regulation of JAK-STAT cascade (GO:0046425) NEW4.780.003CHEK2, RB1, TP53
gonad development (GO:0008406) NEW4.920.021CHEK2, RB1, TP53
protein autophosphorylation (GO:0046777) NEW4.460.031CHEK2, RB1, TP53
adult feeding behavior (GO:0008343) NEW7.430.009CHEK2, TP53
histone acetylation (GO:0016573) NEW5.090.004CHEK2, RB1, TP53
sprouting angiogenesis (GO:0002040) NEW6.510.049RB1, TP53
internal peptidyl-lysine acetylation (GO:0018393) NEW5.050.005CHEK2, RB1, TP53
peptidyl-lysine acetylation (GO:0018394) NEW5.030.005CHEK2, RB1, TP53
astrocyte differentiation (GO:0048708) NEW6.780.01RB1, TP53
spindle organization (GO:0007051) NEW5.330.001CHEK2, RB1, TP53
negative regulation of DNA replication (GO:0008156) NEW6.170.007CHEK2, TP53
response to temperature stimulus (GO:0009266) NEW4.710.027CHEK2, RB1, TP53
negative regulation of cell cycle phase transition (GO:1901988) -4.740.001CHEK2, RB1, TP53
double-strand break repair (GO:0006302) NEW4.730.004CHEK2, RB1, TP53
cell fate commitment (GO:0045165) NEW4.720.03CHEK2, RB1, TP53
sensory organ development (GO:0007423) NEW4.820.017CHEK2, RB1, TP53
regulation of cell cycle phase transition (GO:1901987) -4.150.002CHEK2, RB1, TP53
cranial nerve development (GO:0021545) NEW6.680.0CHEK2, RB1, TP53
tube formation (GO:0035148) NEW4.980.016CHEK2, RB1, TP53
trigeminal nerve development (GO:0021559) NEW8.340.001CHEK2, TP53
axis specification (GO:0009798) NEW5.420.004CHEK2, RB1, TP53
protein polyubiquitination (GO:0000209) NEW4.230.007CHEK2, RB1, TP53
signal transduction involved in cell cycle checkpoint (GO:0072395) -5.540.026CHEK2, TP53
regulation of cell cycle process (GO:0010564) -3.50.011CHEK2, RB1, TP53
regulation of cellular ketone metabolic process (GO:0010565) NEW4.670.043CHEK2, RB1, TP53
microtubule cytoskeleton organization involved in mitosis (GO:1902850) NEW6.170.0CHEK2, RB1, TP53
developmental growth involved in morphogenesis (GO:0060560) NEW5.150.007CHEK2, RB1, TP53
central nervous system neuron differentiation (GO:0021953) NEW5.170.014CHEK2, RB1, TP53
regulation of histone H4 acetylation (GO:0090239) NEW7.330.004RB1, TP53
cellular protein catabolic process (GO:0044257) NEW6.510.022CHEK2, TP53
nerve development (GO:0021675) NEW6.290.001CHEK2, RB1, TP53
palate development (GO:0060021) NEW5.380.005CHEK2, RB1, TP53
intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630) -5.440.034CHEK2, TP53
cell cycle G2/M phase transition (GO:0044839) NEW4.820.006CHEK2, RB1, TP53
mitotic cell cycle process (GO:1903047) -3.120.03CHEK2, RB1, TP53
intrinsic apoptotic signaling pathway (GO:0097193) -4.690.018CHEK2, RB1, TP53
negative regulation of cell cycle process (GO:0010948) -4.370.002CHEK2, RB1, TP53
spindle assembly involved in mitosis (GO:0090307) NEW6.170.01CHEK2, TP53
myoblast differentiation (GO:0045445) NEW6.550.043RB1, TP53
cell division (GO:0051301) -3.680.017CHEK2, RB1, TP53
intracellular receptor signaling pathway (GO:0030522) NEW4.60.043CHEK2, RB1, TP53
response to gamma radiation (GO:0010332) -5.780.011CHEK2, TP53
negative regulation of cytokinesis (GO:0032466) NEW7.780.004RB1, TP53
neuron development (GO:0048666) NEW4.80.046CHEK2, RB1, TP53
glial cell apoptotic process (GO:0034349) -7.650.0RB1, TP53
neuron apoptotic process (GO:0051402) NEW6.150.007RB1, TP53
cellular response to oxidative stress (GO:0034599) NEW4.70.028CHEK2, RB1, TP53
signal transduction in response to DNA damage (GO:0042770) -5.150.003CHEK2, RB1, TP53
inner ear morphogenesis (GO:0042472) NEW5.620.003CHEK2, RB1, TP53
DNA damage checkpoint (GO:0000077) -5.370.037CHEK2, RB1, TP53
cell cycle checkpoint (GO:0000075) -4.790.02CHEK2, RB1, TP53
odontogenesis (GO:0042476) NEW5.190.011CHEK2, RB1, TP53
replicative senescence (GO:0090399) -7.240.001CHEK2, TP53
positive regulation of cell cycle (GO:0045787) -3.940.02CHEK2, RB1, TP53
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular organelle part (GO:0044446) 0.813CHEK2, RB1, TP53
PML body (GO:0016605) 5.243CHEK2, RB1, TP53
nuclear body (GO:0016604) 3.943CHEK2, RB1, TP53
intracellular membrane-bounded organelle (GO:0043231) 0.63CHEK2, RB1, TP53
nucleus (GO:0005634) 1.073CHEK2, RB1, TP53
cell part (GO:0044464) 0.113CHEK2, RB1, TP53
nucleoplasm (GO:0005654) 1.893CHEK2, RB1, TP53
intracellular organelle (GO:0043229) 0.513CHEK2, RB1, TP53
nucleoplasm part (GO:0044451) 3.223CHEK2, RB1, TP53
intracellular part (GO:0044424) 0.283CHEK2, RB1, TP53
nuclear part (GO:0044428) 1.553CHEK2, RB1, TP53
chromosomal part (GO:0044427) 3.183CHEK2, RB1, TP53
membrane-bounded organelle (GO:0043227) 0.473CHEK2, RB1, TP53
organelle (GO:0043226) 0.43CHEK2, RB1, TP53
organelle part (GO:0044422) 0.793CHEK2, RB1, TP53
protein complex (GO:0043234) 1.512RB1, TP53
macromolecular complex (GO:0032991) 1.352RB1, TP53
intracellular non-membrane-bounded organelle (GO:0043232) 1.762RB1, TP53
cytoplasmic part (GO:0044444) 0.822CHEK2, TP53
RNA polymerase II transcription factor complex (GO:0090575) 5.182RB1, TP53
nuclear transcription factor complex (GO:0044798) 4.952RB1, TP53
non-membrane-bounded organelle (GO:0043228) 1.762RB1, TP53
chromatin (GO:0000785) 3.992RB1, TP53
transcription factor complex (GO:0005667) 4.12RB1, TP53

NET-GE enrichment

Term New enriched termICP valueGenes
ciliary basal body (GO:0036064) NEW5.360.046CHEK2, TP53
PML body (GO:0016605) -5.240.0CHEK2, RB1, TP53
nuclear body (GO:0016604) -3.940.0CHEK2, RB1, TP53
transcriptional repressor complex (GO:0017053) NEW5.370.036RB1, TP53
RNA polymerase II transcription factor complex (GO:0090575) -5.180.01RB1, TP53
nucleoplasm (GO:0005654) -1.890.008CHEK2, RB1, TP53
nuclear transcription factor complex (GO:0044798) -4.950.035RB1, TP53
spindle (GO:0005819) NEW4.520.001CHEK2, RB1, TP53
chromatin (GO:0000785) -3.990.029RB1, TP53
germ cell nucleus (GO:0043073) NEW6.760.008CHEK2, TP53
transcription factor complex (GO:0005667) -4.10.019CHEK2, RB1, TP53
nucleoplasm part (GO:0044451) -3.220.002CHEK2, RB1, TP53
chromosome, centromeric region (GO:0000775) NEW4.850.028RB1, TP53
endosome membrane (GO:0010008) NEW3.830.044CHEK2, RB1, TP53