Disease table of LI-FRAUMENI SYNDROME OMIM ID: PS151623

Gene-disease associations table

Gene	Associated with LI-FRAUMENI SYNDROME in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
TP53	ClinVar, OMIM, HUMSAVAR	HGNC link	17p13.1	12	114550, 260500, 605027, PS137800, 614740, 114480, 260350, 607107, 202300, 114500, PS151623, 259500
CDKN2A	HUMSAVAR	HGNC link	9p21.3	4	PS151623, PS155600, 606719, 155755
CHEK2	ClinVar, OMIM, HUMSAVAR	HGNC link	22q12.1	4	PS151623, 176807, 259500, 114480

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
TP53	YES	159	ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING1	2	CHEK2, TP53
HDAC1	NO	64	NFYA, PSIP1, RECK, EIF2AK1, RARB, BIRC3, IGFBP3, CD1D, HSPA5, FOS, CDKN2A, TXNIP, PTGS2, RUNX3, NOS3, RHOB, MICA, EGR1, FAS, KLF4, CLDN7, HMGCS1, CD44, CCND2, MICB, CD82, RECQL4, GRIN2B, SP1, SERPINB5, PHB, BIRC5, COMP, CDC25A, ESR1, FSHR, HOXA9, AR, GAD1, RELN, KLK3, CDH1, SPP1, TP53, PCNA, CXCL8, ICAM1, MGMT, TFF1, EPCAM, STAT3, BRCA2, ABCB1, BCL2A1, SNAI2, HLA-DRA, CDKN1A, MMP28, MMP9, TJP1, TERT, IL2, CCND1, CDKN1B	2	CDKN2A, TP53
HDAC9	NO	22	MYEF2, SOX9, PRL, TP53, DIRAS3, CFLAR, CDKN2A, STAT6, HSPA5, APP, CITED2, IGFBP1, CDKN1A, CLGN, TNFRSF10B, RELA, HPGD, NFKB1, MEF2A, IL18, MMP13, ESR1	2	CDKN2A, TP53
EZH2	NO	31	PCNA, SFRP1, ADRB2, TWIST1, SNAI2, CDKN2B, CDKN2A, APC, RUNX3, PIP5K1C, CCNE1, DACT3, HOXB13, ALDH1A1, BRCA1, FOXC1, CDKN1A, VDR, HDAC1, RPLP0, CDH1, SATB1, TP53, AXL, ADAMTS1, SSTR1, FBXO32, MMP2, PEBP1, CIITA, CCND1	2	CDKN2A, TP53
ETS1	NO	90	PF4, ITGB3, TP53, TBXAS1, GABRE, PTHLH, TNFSF14, CD14, IGFBP1, BAX, SLC26A3, IL2, MGAT5, VWF, HPGD, CA9, MMP3, MMP9, CSF3R, IL2RB, TERT, THY1, FLT1, FGFBP1, CSF2, MYB, FLI1, ANGPT2, GP6, EGR1, TMEM158, CSNK2B, ERG, SQSTM1, WAS, F13A1, CD8A, MMP1, TGFBR2, ABCB1, ATXN2, NDRG1, SPRY2, HSPB8, BMP4, PRL, TBXA2R, CDKN2A, CHUK, NKX3-1, TAF12, MUC4, HSPE1, TRB, AXIN1, BRCA1, LCK, MMP10, SPP1, RHOC, ICAM1, ANPEP, CSNK2A1, IL5, CR1, HSPA6, HMOX1, CASP1, MDM2, PLAU, SNAI1, TFAP2A, CTSB, TRA, CXCR4, ECE1, SRD5A1, HSPA1L, DUSP6, CDKN1A, FOXD1, GRPR, CTGF, PARP1, TNC, HSPA8, IL3, COL1A1, MMP13, CD6	2	CDKN2A, TP53
ETS2	NO	35	CDK1, MDM2, PDE7A, TP53, CSF2, MMP2, MMP9, FLI1, MSR1, CDKN2A, IL12B, ANGPT2, APP, EGR1, TAL1, ERG, CHRNE, CDKN1A, LCK, SPP1, CD163, TLR9, VWF, ICAM1, CGA, ANPEP, TNC, CXCL8, MMP3, DUSP6, MMP1, CSF3R, IL5, TERT, MYC	2	CDKN2A, TP53
E2F1	NO	123	WWOX, DOK1, MEFV, MYBL2, MCM8, FZD1, DIRAS3, PIN1, PCNA, DHFR, ETV4, LRBA, RPA2, FSHR, SERPINB5, PCSK6, TP53, FOXM1, E2F1, IL23A, CD2AP, HMGA1, XRCC1, FHIT, IRF3, ATM, MYC, MT1G, NRIP1, FLT1, RRP1B, MYB, SERPINE1, BMI1, CDKN2A, SKP2, MAPK8, CCNE1, CASP7, CDCA7, HIC1, THBS1, RB1, TNF, IL1B, ULK1, ERCC1, CUX1, TERT, MCL1, AR, KIR3DL1, NPAT, PDK4, DDB2, E2F6, ABCB1, BBC3, AURKA, NOX4, MYCN, CCNB1, TP73, FGFR1, RRM1, RRM2, HSPA5, TLR3, MUC4, CCND1, MCPH1, BRCA1, DRAM1, ERCC5, BIRC5, TYMS, RASGEF1B, MAP1LC3A, VEGFA, RACGAP1, FANCA, UHRF1, CHEK1, MCM5, RASGRP1, APAF1, ISYNA1, ECT2, TNFSF11, AURKB, CDK1, MDM2, DDIT3, MAP3K5, DBF4, PNRC2, KIF2C, POLA1, CTNNBIP1, ELF4, KDR, TP53INP1, ATAD2, CCL3, TK1, ATG5, CDKN1A, SIVA1, PEG10, TOP2A, CDAN1, CHEK2, DUSP1, ASF1B, DAPK2, PTPRO, BCL2, CREBBP, TP53BP2, GINS3, MYH10, PPARG, PPP1R13B	3	CHEK2, CDKN2A, TP53

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
TP53	YES	50	ATM, RELA, ERCC2, ETS2, ELF4, EZH2, HDAC9, FOS, PAX5, MCM4, RUVBL1, ZBTB2, EGR1, KLF4, MCM2, AATF, PAX2, TFDP1, STAT1, IRF1, PAX8, HIPK2, HDAC1, SIRT1, MDM4, VHL, ESR1, ING1, IFI16, STAT3, JUN, TP53, ABL1, NUPR1, NFKB1, E2F1, ETS1, CREBBP, HOXA10, NR3C1, YY1, NF1, ING4, HMGA1, SOX6, BDP1, MYC, PPARG, PML, MYCN	1	TP53
CDKN2A	YES	24	FOXM1, EAPP, ETS2, EZH2, DNMT3A, HDAC9, ZBTB7A, SP1, HDAC3, MTA1, DNMT1, TBX2, E2F1, SMARCB1, TBX3, ZNF148, HDAC1, HDAC4, ETS1, SMARCA1, TBX5, SMARCA4, SP3, JUNB	0
CHEK2	YES	2	E2F1, TP53	1	TP53

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
TP53	CDKN2A	Yes	70	BCL2L1, AURKA, RNF2, ING4, EPHA3, ACTB, HSPA4, PDCD6, ZBTB17, PIAS2, MAPK10, TUBB, HSP90AB1, TAT, PCNA, KAT5, SP1, IQGAP1, EEF2, MDM2, EGR1, MAPK8, UBE4B, UCHL1, PSMC3, TUBA1C, HNRNPA2B1, TUBA1A, COPS5, BRCA1, WRN, NCL, VHL, HSPA9, SIVA1, SENP3, GAPDH, ING1, HDAC1, CCNG1, ATR, TRIM28, HSP90AA1, IKBKB, TP53, RELA, NPM1, RPL11, PSME3, TOP1, DAXX, UBE2I, MOV10, MYO1C, PPP1CC, HSPA8, ACTBL2, TP63, YY1, TUBB4B, HUWE1, ZNF420, GNL3, HNRNPU, MDM4, SMARCA4, MYC, UBE2A, HIF1A, E4F1
TP53	CHEK2	Yes	36	ATM, KAT2B, MDC1, VCP, SRPK1, MAPK3, TP53, DAPK3, TP53BP1, RNF20, ATR, MDM2, MSH2, RCHY1, BRCA1, PPP2R5C, SIRT1, VHL, CUL4A, PRKDC, FOXK2, ELAVL1, NR4A1, TRIM28, PPP2R1A, PSME3, FOXK1, UBR5, BRCA2, PLK3, MAPK1, PLK1, RB1, CHEK2, PML, MDM4
CDKN2A	CHEK2	No	9	VHL, ATR, PSME3, MDM2, TRIM28, MDM4, TP53, BRCA1, WHSC1L1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
TP53	CHEK2	Yes	activation, binding	33	KAT2B, PLK3, TREX1, MDM2, CHEK1, CDC25A, TP53BP1, ATR, FOXM1, MSH2, PPM1D, RCHY1, BRCA1, YWHAZ, VHL, CDKN1A, ELAVL1, TOP2A, H2AFX, BRCA2, TP63, WRN, CABIN1, ASF1A, PLK1, KPNA2, RB1, MDM4, SFN, UBC, TP73, PML, CDC25C

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

Gene1	Gene2	Direct interaction	More information
CHEK2	TP53	yes, they interact	TP53 is phosphorylated on Ser-20 by CHEK2 in response to DNA damage. [UniProt]

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
HTLV-I infection	hsa05166	4.59	3	CDKN2A, CHEK2, TP53
Cell cycle	hsa04110	5.68	3	CDKN2A, CHEK2, TP53
p53 signaling pathway	hsa04115	6.56	3	CHEK2, CDKN2A, TP53
Melanoma	hsa05218	6.56	2	CDKN2A, TP53
Bladder cancer	hsa05219	7.38	2	CDKN2A, TP53
Pancreatic cancer	hsa05212	6.56	2	CDKN2A, TP53
MicroRNAs in cancer	hsa05206	5.38	2	CDKN2A, TP53
Pathways in cancer	hsa05200	3.98	2	CDKN2A, TP53
Glioma	hsa05214	6.66	2	CDKN2A, TP53
Non-small cell lung cancer	hsa05223	6.88	2	CDKN2A, TP53
Viral carcinogenesis	hsa05203	5.08	2	CDKN2A, TP53
Chronic myeloid leukemia	hsa05220	6.48	2	CDKN2A, TP53

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Melanoma (hsa05218)	-	6.56	0.0	CDKN2A, TP53
Bladder cancer (hsa05219)	-	7.38	0.0	CDKN2A, TP53
Pancreatic cancer (hsa05212)	-	6.56	0.001	CDKN2A, TP53
Infectious diseases: Viral	NEW	3.29	0.005	CHEK2, CDKN2A, TP53
MicroRNAs in cancer (hsa05206)	-	5.38	0.003	CDKN2A, TP53
Pathways in cancer (hsa05200)	-	3.98	0.045	CDKN2A, TP53
Viral carcinogenesis (hsa05203)	-	5.08	0.005	CDKN2A, TP53
Cell growth and death	NEW	4.41	0.004	CHEK2, CDKN2A, TP53
Cancers: Specific types	NEW	4.1	0.036	CDKN2A, TP53
Non-small cell lung cancer (hsa05223)	-	6.88	0.0	CDKN2A, TP53
Glioma (hsa05214)	-	6.66	0.0	CDKN2A, TP53
Chronic myeloid leukemia (hsa05220)	-	6.48	0.002	CDKN2A, TP53
HTLV-I infection (hsa05166)	-	4.59	0.005	CDKN2A, CHEK2, TP53
p53 signaling pathway (hsa04115)	-	6.56	0.0	CHEK2, CDKN2A, TP53
Cell cycle (hsa04110)	-	5.68	0.0	CDKN2A, CHEK2, TP53

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Cell Cycle	R-HSA-1640170	3.89	3	CHEK2, CDKN2A, TP53
Oncogene Induced Senescence	R-HSA-2559585	8.03	2	CDKN2A, TP53
G1/S DNA Damage Checkpoints	R-HSA-69615	7.08	2	CHEK2, TP53
Oxidative Stress Induced Senescence	R-HSA-2559580	6.51	2	CDKN2A, TP53
Cellular Senescence	R-HSA-2559583	5.7	2	CDKN2A, TP53
Cellular responses to stress	R-HSA-2262752	4.56	2	CDKN2A, TP53
Cell Cycle Checkpoints	R-HSA-69620	5.64	2	CHEK2, TP53

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Oncogene Induced Senescence (R-HSA-2559585)	-	8.03	0.0	CDKN2A, TP53
Oxidative Stress Induced Senescence (R-HSA-2559580)	-	6.51	0.004	CDKN2A, TP53
Cellular Senescence (R-HSA-2559583)	-	5.7	0.001	CDKN2A, TP53
Cellular responses to stress (R-HSA-2262752)	-	4.56	0.014	CHEK2, CDKN2A, TP53
G1/S DNA Damage Checkpoints (R-HSA-69615)	-	7.08	0.015	CHEK2, TP53
G1 Phase (R-HSA-69236)	NEW	7.73	0.042	CDKN2A, TP53
Cyclin D associated events in G1 (R-HSA-69231)	NEW	7.73	0.042	CDKN2A, TP53

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
organic cyclic compound binding (GO:0097159)	1.05	3	CHEK2, CDKN2A, TP53
enzyme binding (GO:0019899)	2.27	3	CHEK2, CDKN2A, TP53
protein kinase binding (GO:0019901)	3.44	3	CDKN2A, CHEK2, TP53
kinase binding (GO:0019900)	3.32	3	CHEK2, CDKN2A, TP53
binding (GO:0005488)	0.18	3	CDKN2A, CHEK2, TP53
protein binding (GO:0005515)	0.46	3	CHEK2, CDKN2A, TP53
heterocyclic compound binding (GO:1901363)	1.06	3	CHEK2, CDKN2A, TP53
ubiquitin-like protein ligase binding (GO:0044389)	4.15	2	CHEK2, TP53
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	2	CHEK2, TP53
nucleic acid binding (GO:0003676)	1.44	2	CDKN2A, TP53
DNA binding (GO:0003677)	1.92	2	CDKN2A, TP53
nucleotide binding (GO:0000166)	1.96	2	CHEK2, TP53
nucleoside phosphate binding (GO:1901265)	1.96	2	CHEK2, TP53
nucleoside binding (GO:0001882)	2.21	2	CHEK2, TP53
cation binding (GO:0043169)	1.4	2	CHEK2, TP53
ion binding (GO:0043167)	1.36	2	CHEK2, TP53
transferase activity (GO:0016740)	1.95	2	CDKN2A, CHEK2
purine nucleoside binding (GO:0001883)	2.22	2	CHEK2, TP53
ribonucleoside binding (GO:0032549)	2.22	2	CHEK2, TP53
purine nucleotide binding (GO:0017076)	2.19	2	CHEK2, TP53
metal ion binding (GO:0046872)	1.41	2	CHEK2, TP53
identical protein binding (GO:0042802)	2.63	2	CHEK2, TP53
transcription factor binding (GO:0008134)	3.46	2	CDKN2A, TP53
kinase activity (GO:0016301)	2.93	2	CDKN2A, CHEK2
small molecule binding (GO:0036094)	1.89	2	CHEK2, TP53
catalytic activity (GO:0003824)	1.05	2	CDKN2A, CHEK2
ubiquitin protein ligase binding (GO:0031625)	4.17	2	CHEK2, TP53
adenyl nucleotide binding (GO:0030554)	2.4	2	CHEK2, TP53
carbohydrate derivative binding (GO:0097367)	2.03	2	CHEK2, TP53
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	2	CDKN2A, CHEK2
adenyl ribonucleotide binding (GO:0032559)	2.41	2	CHEK2, TP53
ATP binding (GO:0005524)	2.43	2	CHEK2, TP53
purine ribonucleotide binding (GO:0032555)	2.2	2	CHEK2, TP53
protein dimerization activity (GO:0046983)	2.72	2	CHEK2, TP53
p53 binding (GO:0002039)	5.53	2	CDKN2A, TP53
purine ribonucleoside binding (GO:0032550)	2.22	2	CHEK2, TP53
ribonucleotide binding (GO:0032553)	2.19	2	CHEK2, TP53

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
enzyme regulator activity (GO:0030234)	NEW	2.85	0.047	CDKN2A, TP53
protein C-terminus binding (GO:0008022)	NEW	4.5	0.047	CHEK2, CDKN2A, TP53
phosphatidylinositol-4-phosphate binding (GO:0070273)	NEW	6.74	0.006	CDKN2A, TP53
cyclin-dependent protein serine/threonine kinase regulator activity (GO:0016538)	NEW	6.41	0.01	CDKN2A, TP53
MDM2/MDM4 family protein binding (GO:0097371)	NEW	7.95	0.0	CDKN2A, TP53
transcription factor binding (GO:0008134)	-	3.46	0.01	CDKN2A, CHEK2, TP53
core promoter proximal region DNA binding (GO:0001159)	NEW	3.82	0.04	CHEK2, CDKN2A, TP53
enhancer sequence-specific DNA binding (GO:0001158)	NEW	5.36	0.001	CDKN2A, CHEK2, TP53
protein kinase binding (GO:0019901)	-	3.44	0.005	CHEK2, CDKN2A, TP53
kinase binding (GO:0019900)	-	3.32	0.007	CHEK2, CDKN2A, TP53
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001077)	NEW	4.31	0.027	CDKN2A, CHEK2, TP53
enhancer binding (GO:0035326)	NEW	5.21	0.002	CDKN2A, CHEK2, TP53
RNA polymerase II activating transcription factor binding (GO:0001102)	NEW	6.13	0.047	CDKN2A, TP53
core promoter proximal region sequence-specific DNA binding (GO:0000987)	NEW	3.83	0.039	CHEK2, CDKN2A, TP53
p53 binding (GO:0002039)	-	5.53	0.005	CDKN2A, TP53
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978)	NEW	3.88	0.036	CHEK2, CDKN2A, TP53

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
regulation of phosphate metabolic process (GO:0019220)	2.35	3	CHEK2, CDKN2A, TP53
regulation of primary metabolic process (GO:0080090)	1.08	3	CDKN2A, CHEK2, TP53
regulation of metabolic process (GO:0019222)	1.02	3	CDKN2A, CHEK2, TP53
regulation of response to stimulus (GO:0048583)	1.54	3	CHEK2, CDKN2A, TP53
signal transduction (GO:0007165)	1.28	3	CDKN2A, CHEK2, TP53
organic substance biosynthetic process (GO:1901576)	1.34	3	CHEK2, CDKN2A, TP53
organic cyclic compound biosynthetic process (GO:1901362)	1.66	3	CDKN2A, CHEK2, TP53
cellular component organization or biogenesis (GO:0071840)	1.22	3	CDKN2A, CHEK2, TP53
positive regulation of apoptotic process (GO:0043065)	3.38	3	CDKN2A, CHEK2, TP53
cellular response to stimulus (GO:0051716)	1.97	3	CDKN2A, CHEK2, TP53
negative regulation of cell cycle (GO:0045786)	3.67	3	CDKN2A, CHEK2, TP53
positive regulation of cell cycle (GO:0045787)	3.94	3	CDKN2A, CHEK2, TP53
regulation of signal transduction (GO:0009966)	1.84	3	CHEK2, CDKN2A, TP53
cellular developmental process (GO:0048869)	1.82	3	CDKN2A, CHEK2, TP53
peptidyl-amino acid modification (GO:0018193)	2.98	3	CHEK2, CDKN2A, TP53
positive regulation of biological process (GO:0048518)	1.2	3	CDKN2A, CHEK2, TP53
regulation of signal transduction by p53 class mediator (GO:1901796)	4.63	3	CDKN2A, CHEK2, TP53
regulation of DNA metabolic process (GO:0051052)	3.87	3	CDKN2A, CHEK2, TP53
regulation of macromolecule metabolic process (GO:0060255)	1.08	3	CHEK2, CDKN2A, TP53
regulation of RNA biosynthetic process (GO:2001141)	1.55	3	CHEK2, CDKN2A, TP53
heterocycle metabolic process (GO:0046483)	1.31	3	CDKN2A, CHEK2, TP53
regulation of phosphorylation (GO:0042325)	2.5	3	CDKN2A, CHEK2, TP53
protein metabolic process (GO:0019538)	1.45	3	CHEK2, CDKN2A, TP53
regulation of gene expression (GO:0010468)	1.37	3	CDKN2A, CHEK2, TP53
cellular response to stress (GO:0033554)	2.51	3	CDKN2A, CHEK2, TP53
aromatic compound biosynthetic process (GO:0019438)	1.7	3	CHEK2, CDKN2A, TP53
cellular component assembly (GO:0022607)	2.14	3	CDKN2A, CHEK2, TP53
negative regulation of metabolic process (GO:0009892)	1.93	3	CDKN2A, CHEK2, TP53
positive regulation of metabolic process (GO:0009893)	1.74	3	CDKN2A, CHEK2, TP53
negative regulation of biosynthetic process (GO:0009890)	2.47	3	CDKN2A, CHEK2, TP53
positive regulation of biosynthetic process (GO:0009891)	2.29	3	CDKN2A, CHEK2, TP53
positive regulation of gene expression (GO:0010628)	2.35	3	CHEK2, CDKN2A, TP53
intracellular signal transduction (GO:0035556)	2.39	3	CDKN2A, CHEK2, TP53
regulation of apoptotic process (GO:0042981)	2.5	3	CDKN2A, CHEK2, TP53
regulation of biological process (GO:0050789)	0.45	3	CHEK2, CDKN2A, TP53
nucleic acid-templated transcription (GO:0097659)	1.91	3	CHEK2, CDKN2A, TP53
cellular protein metabolic process (GO:0044267)	1.63	3	CHEK2, CDKN2A, TP53
regulation of mitotic cell cycle (GO:0007346)	3.71	3	CDKN2A, CHEK2, TP53
cellular macromolecule metabolic process (GO:0044260)	0.93	3	CDKN2A, CHEK2, TP53
cellular component organization (GO:0016043)	1.24	3	CHEK2, CDKN2A, TP53
biological regulation (GO:0065007)	0.39	3	CHEK2, CDKN2A, TP53
organic cyclic compound metabolic process (GO:1901360)	1.26	3	CHEK2, CDKN2A, TP53
regulation of biological quality (GO:0065008)	1.68	3	CHEK2, CDKN2A, TP53
heterocycle biosynthetic process (GO:0018130)	1.7	3	CDKN2A, CHEK2, TP53
regulation of biosynthetic process (GO:0009889)	1.37	3	CDKN2A, CHEK2, TP53
regulation of cellular process (GO:0050794)	0.5	3	CDKN2A, CHEK2, TP53
programmed cell death (GO:0012501)	3.1	3	CDKN2A, CHEK2, TP53
macromolecule modification (GO:0043412)	1.73	3	CHEK2, CDKN2A, TP53
protein modification process (GO:0036211)	1.79	3	CHEK2, CDKN2A, TP53
metabolic process (GO:0008152)	0.58	3	CDKN2A, CHEK2, TP53
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	3	CDKN2A, CHEK2, TP53
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	3	CHEK2, CDKN2A, TP53
regulation of intracellular signal transduction (GO:1902531)	2.31	3	CDKN2A, CHEK2, TP53
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	3	CDKN2A, CHEK2, TP53
RNA metabolic process (GO:0016070)	1.59	3	CDKN2A, CHEK2, TP53
regulation of phosphorus metabolic process (GO:0051174)	2.35	3	CHEK2, CDKN2A, TP53
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	3	CHEK2, CDKN2A, TP53
regulation of cell cycle phase transition (GO:1901987)	4.15	3	CHEK2, CDKN2A, TP53
response to stimulus (GO:0050896)	1.22	3	CHEK2, CDKN2A, TP53
positive regulation of protein modification process (GO:0031401)	2.7	3	CDKN2A, CHEK2, TP53
response to stress (GO:0006950)	1.8	3	CHEK2, CDKN2A, TP53
regulation of transcription, DNA-templated (GO:0006355)	1.56	3	CDKN2A, CHEK2, TP53
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	3	CHEK2, CDKN2A, TP53
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	3	CDKN2A, CHEK2, TP53
transcription, DNA-templated (GO:0006351)	1.91	3	CHEK2, CDKN2A, TP53
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	3	CDKN2A, CHEK2, TP53
RNA biosynthetic process (GO:0032774)	1.84	3	CDKN2A, CHEK2, TP53
regulation of protein metabolic process (GO:0051246)	1.93	3	CDKN2A, CHEK2, TP53
cellular biosynthetic process (GO:0044249)	1.37	3	CDKN2A, CHEK2, TP53
cellular nitrogen compound metabolic process (GO:0034641)	1.22	3	CDKN2A, CHEK2, TP53
regulation of mitotic cell cycle phase transition (GO:1901990)	4.23	3	CHEK2, CDKN2A, TP53
cellular macromolecule biosynthetic process (GO:0034645)	1.66	3	CDKN2A, CHEK2, TP53
regulation of signaling (GO:0023051)	1.72	3	CDKN2A, CHEK2, TP53
regulation of cell communication (GO:0010646)	1.73	3	CHEK2, CDKN2A, TP53
single-organism process (GO:0044699)	0.48	3	CHEK2, CDKN2A, TP53
nucleobase-containing compound metabolic process (GO:0006139)	1.35	3	CDKN2A, CHEK2, TP53
regulation of cell cycle process (GO:0010564)	3.5	3	CDKN2A, CHEK2, TP53
positive regulation of protein metabolic process (GO:0051247)	2.43	3	CHEK2, CDKN2A, TP53
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	3	CDKN2A, CHEK2, TP53
regulation of protein modification process (GO:0031399)	2.32	3	CDKN2A, CHEK2, TP53
developmental process (GO:0032502)	1.36	3	CHEK2, CDKN2A, TP53
cellular process (GO:0009987)	0.26	3	CHEK2, CDKN2A, TP53
cellular aromatic compound metabolic process (GO:0006725)	1.3	3	CDKN2A, CHEK2, TP53
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	3	CHEK2, CDKN2A, TP53
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	3	CDKN2A, CHEK2, TP53
negative regulation of biological process (GO:0048519)	1.33	3	CDKN2A, CHEK2, TP53
cell cycle (GO:0007049)	3.14	3	CDKN2A, CHEK2, TP53
regulation of cellular protein metabolic process (GO:0032268)	1.99	3	CHEK2, CDKN2A, TP53
aging (GO:0007568)	4.16	3	CHEK2, CDKN2A, TP53
cell aging (GO:0007569)	5.54	3	CDKN2A, CHEK2, TP53
regulation of RNA metabolic process (GO:0051252)	1.52	3	CHEK2, CDKN2A, TP53
positive regulation of RNA metabolic process (GO:0051254)	2.51	3	CHEK2, CDKN2A, TP53
macromolecule metabolic process (GO:0043170)	0.83	3	CHEK2, CDKN2A, TP53
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	3	CHEK2, CDKN2A, TP53
nitrogen compound metabolic process (GO:0006807)	1.13	3	CHEK2, CDKN2A, TP53
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	3	CHEK2, CDKN2A, TP53
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	3	CHEK2, CDKN2A, TP53
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	3	CHEK2, CDKN2A, TP53
regulation of cellular biosynthetic process (GO:0031326)	1.38	3	CHEK2, CDKN2A, TP53
positive regulation of cellular metabolic process (GO:0031325)	1.81	3	CDKN2A, CHEK2, TP53
negative regulation of cellular metabolic process (GO:0031324)	2.01	3	CHEK2, CDKN2A, TP53
regulation of cellular metabolic process (GO:0031323)	1.07	3	CDKN2A, CHEK2, TP53
mitotic cell cycle process (GO:1903047)	3.12	3	CDKN2A, CHEK2, TP53
nucleic acid metabolic process (GO:0090304)	1.46	3	CHEK2, CDKN2A, TP53
cell cycle process (GO:0022402)	2.75	3	CHEK2, CDKN2A, TP53
positive regulation of cell death (GO:0010942)	3.32	3	CHEK2, CDKN2A, TP53
cell death (GO:0008219)	3.05	3	CHEK2, CDKN2A, TP53
regulation of cell death (GO:0010941)	2.43	3	CDKN2A, CHEK2, TP53
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	3	CDKN2A, CHEK2, TP53
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	3	CDKN2A, CHEK2, TP53
positive regulation of cell cycle arrest (GO:0071158)	5.29	3	CHEK2, CDKN2A, TP53
organic substance metabolic process (GO:0071704)	0.63	3	CHEK2, CDKN2A, TP53
regulation of programmed cell death (GO:0043067)	2.49	3	CDKN2A, CHEK2, TP53
positive regulation of programmed cell death (GO:0043068)	3.38	3	CDKN2A, CHEK2, TP53
regulation of cell cycle arrest (GO:0071156)	5.05	3	CDKN2A, CHEK2, TP53
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	3	CDKN2A, CHEK2, TP53
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	3	CDKN2A, CHEK2, TP53
positive regulation of cell cycle process (GO:0090068)	4.25	3	CHEK2, CDKN2A, TP53
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	3	CHEK2, CDKN2A, TP53
apoptotic process (GO:0006915)	3.14	3	CDKN2A, CHEK2, TP53
cellular protein modification process (GO:0006464)	1.79	3	CHEK2, CDKN2A, TP53
single-organism developmental process (GO:0044767)	1.49	3	CDKN2A, CHEK2, TP53
biosynthetic process (GO:0009058)	1.32	3	CHEK2, CDKN2A, TP53
macromolecule biosynthetic process (GO:0009059)	1.61	3	CDKN2A, CHEK2, TP53
single-organism cellular process (GO:0044763)	0.65	3	CDKN2A, CHEK2, TP53
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	3	CDKN2A, CHEK2, TP53
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	3	CDKN2A, CHEK2, TP53
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	3	CDKN2A, CHEK2, TP53
organelle organization (GO:0006996)	2.02	3	CHEK2, CDKN2A, TP53
primary metabolic process (GO:0044238)	0.69	3	CDKN2A, CHEK2, TP53
regulation of cell cycle (GO:0051726)	2.93	3	CDKN2A, CHEK2, TP53
replicative senescence (GO:0090399)	7.24	3	CHEK2, CDKN2A, TP53
cellular metabolic process (GO:0044237)	0.69	3	CHEK2, CDKN2A, TP53
single-organism organelle organization (GO:1902589)	2.68	3	CDKN2A, CHEK2, TP53
regulation of protein phosphorylation (GO:0001932)	2.57	3	CHEK2, CDKN2A, TP53
negative regulation of cellular process (GO:0048523)	1.41	3	CDKN2A, CHEK2, TP53
positive regulation of cellular process (GO:0048522)	1.3	3	CHEK2, CDKN2A, TP53
regulation of intracellular protein transport (GO:0033157)	3.8	2	CDKN2A, TP53
regulation of transport (GO:0051049)	2.24	2	CDKN2A, TP53
regulation of intracellular transport (GO:0032386)	3.58	2	CDKN2A, TP53
positive regulation of response to stimulus (GO:0048584)	2.18	2	CDKN2A, TP53
signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	5.59	2	CHEK2, TP53
signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	5.59	2	CHEK2, TP53
intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	5.59	2	CHEK2, TP53
mitochondrion organization (GO:0007005)	3.69	2	CDKN2A, TP53
protein sumoylation (GO:0016925)	4.98	2	CDKN2A, TP53
negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)	5.17	2	CHEK2, TP53
signal transduction involved in DNA damage checkpoint (GO:0072422)	5.55	2	CHEK2, TP53
positive regulation of signal transduction (GO:0009967)	2.5	2	CDKN2A, TP53
protein modification by small protein conjugation or removal (GO:0070647)	2.95	2	CDKN2A, TP53
protein modification by small protein conjugation (GO:0032446)	3.1	2	CDKN2A, TP53
negative regulation of molecular function (GO:0044092)	2.74	2	CDKN2A, TP53
regulation of cell proliferation (GO:0042127)	2.41	2	CDKN2A, TP53
negative regulation of DNA metabolic process (GO:0051053)	4.98	2	CHEK2, TP53
DNA repair (GO:0006281)	3.59	2	CHEK2, TP53
protein catabolic process (GO:0030163)	3.93	2	CHEK2, TP53
regulation of response to DNA damage stimulus (GO:2001020)	4.74	2	CDKN2A, CHEK2
signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	5.59	2	CHEK2, TP53
intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630)	5.44	2	CHEK2, TP53
cellular catabolic process (GO:0044248)	2.62	2	CHEK2, TP53
positive regulation of phosphorylation (GO:0042327)	2.9	2	CHEK2, TP53
peptidyl-lysine modification (GO:0018205)	3.98	2	CDKN2A, TP53
regulation of catabolic process (GO:0009894)	3.52	2	CDKN2A, CHEK2
chromatin assembly (GO:0031497)	6.55	2	CDKN2A, TP53
protein stabilization (GO:0050821)	4.86	2	CDKN2A, CHEK2
negative regulation of gene expression (GO:0010629)	2.48	2	CDKN2A, TP53
regulation of protein transport (GO:0051223)	3.12	2	CDKN2A, TP53
signal transduction by p53 class mediator (GO:0072331)	4.88	2	CHEK2, TP53
signal transduction involved in DNA integrity checkpoint (GO:0072401)	5.55	2	CHEK2, TP53
organic substance catabolic process (GO:1901575)	2.45	2	CHEK2, TP53
cellular macromolecule catabolic process (GO:0044265)	3.19	2	CHEK2, TP53
DNA integrity checkpoint (GO:0031570)	5.25	2	CHEK2, TP53
negative regulation of transferase activity (GO:0051348)	3.87	2	CDKN2A, TP53
macromolecular complex assembly (GO:0065003)	2.55	2	CDKN2A, TP53
regulation of molecular function (GO:0065009)	1.78	2	CDKN2A, TP53
regulation of execution phase of apoptosis (GO:1900117)	6.55	2	CDKN2A, TP53
regulation of establishment of protein localization (GO:0070201)	3.02	2	CDKN2A, TP53
regulation of catalytic activity (GO:0050790)	1.97	2	CDKN2A, TP53
phosphorylation (GO:0016310)	2.63	2	CDKN2A, CHEK2
cellular senescence (GO:0090398)	6.26	2	CDKN2A, TP53
cell cycle arrest (GO:0007050)	4.69	2	CDKN2A, TP53
positive regulation of intracellular signal transduction (GO:1902533)	2.95	2	CDKN2A, TP53
negative regulation of cell cycle phase transition (GO:1901988)	4.74	2	CHEK2, TP53
regulation of hydrolase activity (GO:0051336)	2.53	2	CDKN2A, TP53
regulation of response to stress (GO:0080134)	2.53	2	CDKN2A, CHEK2
regulation of cellular response to stress (GO:0080135)	3.4	2	CDKN2A, CHEK2
regulation of transferase activity (GO:0051338)	2.88	2	CDKN2A, TP53
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	2	CDKN2A, TP53
regulation of nucleocytoplasmic transport (GO:0046822)	4.33	2	CDKN2A, TP53
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	2	CHEK2, TP53
negative regulation of cell growth (GO:0030308)	4.58	2	CDKN2A, TP53
regulation of organelle organization (GO:0033043)	2.72	2	CDKN2A, TP53
response to radiation (GO:0009314)	3.69	2	CHEK2, TP53
regulation of cellular component organization (GO:0051128)	2.01	2	CDKN2A, TP53
regulation of cellular protein localization (GO:1903827)	3.43	2	CDKN2A, TP53
regulation of protein catabolic process (GO:0042176)	3.83	2	CDKN2A, CHEK2
negative regulation of mitotic cell cycle phase transition (GO:1901991)	4.82	2	CHEK2, TP53
cellular response to chemical stimulus (GO:0070887)	2.57	2	CHEK2, TP53
positive regulation of cell communication (GO:0010647)	2.41	2	CDKN2A, TP53
negative regulation of catalytic activity (GO:0043086)	3.0	2	CDKN2A, TP53
positive regulation of cellular protein localization (GO:1903829)	3.85	2	CDKN2A, TP53
regulation of protein localization (GO:0032880)	2.88	2	CDKN2A, TP53
response to ionizing radiation (GO:0010212)	4.74	2	CHEK2, TP53
signal transduction involved in cell cycle checkpoint (GO:0072395)	5.54	2	CHEK2, TP53
signal transduction in response to DNA damage (GO:0042770)	5.15	2	CHEK2, TP53
negative regulation of cell proliferation (GO:0008285)	3.26	2	CDKN2A, TP53
negative regulation of nucleic acid-templated transcription (GO:1903507)	2.71	2	CDKN2A, TP53
cellular response to DNA damage stimulus (GO:0006974)	3.17	2	CHEK2, TP53
regulation of establishment of protein localization to mitochondrion (GO:1903747)	4.88	2	CDKN2A, TP53
regulation of cell growth (GO:0001558)	3.75	2	CDKN2A, TP53
negative regulation of transcription, DNA-templated (GO:0045892)	2.75	2	CDKN2A, TP53
regulation of localization (GO:0032879)	1.94	2	CDKN2A, TP53
regulation of G1/S transition of mitotic cell cycle (GO:2000045)	4.81	2	CHEK2, TP53
negative regulation of RNA metabolic process (GO:0051253)	2.66	2	CDKN2A, TP53
response to drug (GO:0042493)	3.71	2	CHEK2, TP53
chromatin assembly or disassembly (GO:0006333)	5.52	2	CDKN2A, TP53
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	2	CDKN2A, TP53
regulation of protein stability (GO:0031647)	4.33	2	CDKN2A, CHEK2
negative regulation of growth (GO:0045926)	4.24	2	CDKN2A, TP53
regulation of cellular localization (GO:0060341)	3.03	2	CDKN2A, TP53
macromolecular complex subunit organization (GO:0043933)	2.14	2	CDKN2A, TP53
apoptotic signaling pathway (GO:0097190)	4.12	2	CHEK2, TP53
intrinsic apoptotic signaling pathway (GO:0097193)	4.69	2	CHEK2, TP53
cell cycle phase transition (GO:0044770)	4.24	2	CDKN2A, CHEK2
mitotic cell cycle phase transition (GO:0044772)	4.27	2	CDKN2A, CHEK2
cellular response to drug (GO:0035690)	5.48	2	CHEK2, TP53
regulation of mitochondrion organization (GO:0010821)	4.34	2	CDKN2A, TP53
cell division (GO:0051301)	3.68	2	CDKN2A, CHEK2
chromatin organization (GO:0006325)	3.28	2	CDKN2A, TP53
regulation of growth (GO:0040008)	3.26	2	CDKN2A, TP53
response to gamma radiation (GO:0010332)	5.78	2	CHEK2, TP53
regulation of protein export from nucleus (GO:0046825)	6.23	2	CDKN2A, TP53
negative regulation of cell cycle process (GO:0010948)	4.37	2	CHEK2, TP53
negative regulation of mitotic cell cycle (GO:0045930)	4.45	2	CHEK2, TP53
positive regulation of phosphate metabolic process (GO:0045937)	2.78	2	CHEK2, TP53
DNA damage response, signal transduction by p53 class mediator (GO:0030330)	5.3	2	CHEK2, TP53
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	2	CDKN2A, TP53
response to chemical (GO:0042221)	1.98	2	CHEK2, TP53
Ras protein signal transduction (GO:0007265)	4.76	2	CDKN2A, TP53
small GTPase mediated signal transduction (GO:0007264)	3.85	2	CDKN2A, TP53
catabolic process (GO:0009056)	2.38	2	CHEK2, TP53
macromolecule catabolic process (GO:0009057)	3.0	2	CHEK2, TP53
positive regulation of signaling (GO:0023056)	2.41	2	CDKN2A, TP53
response to abiotic stimulus (GO:0009628)	2.8	2	CHEK2, TP53
DNA damage checkpoint (GO:0000077)	5.37	2	CHEK2, TP53
positive regulation of leukocyte apoptotic process (GO:2000108)	6.33	2	CDKN2A, TP53
cell cycle checkpoint (GO:0000075)	4.79	2	CHEK2, TP53
signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	5.59	2	CHEK2, TP53
regulation of leukocyte apoptotic process (GO:2000106)	5.33	2	CDKN2A, TP53
regulation of cell cycle G1/S phase transition (GO:1902806)	4.74	2	CHEK2, TP53
negative regulation of cell cycle G1/S phase transition (GO:1902807)	5.14	2	CHEK2, TP53
phosphate-containing compound metabolic process (GO:0006796)	2.16	2	CDKN2A, CHEK2
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:0006977)	5.6	2	CHEK2, TP53
regulation of cell cycle G2/M phase transition (GO:1902749)	5.63	2	CDKN2A, TP53
phosphorus metabolic process (GO:0006793)	2.15	2	CDKN2A, CHEK2
DNA metabolic process (GO:0006259)	3.09	2	CHEK2, TP53
positive regulation of protein phosphorylation (GO:0001934)	2.95	2	CHEK2, TP53

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
negative regulation of kinase activity (GO:0033673)	NEW	4.22	0.003	CDKN2A, CHEK2, TP53
regulation of cell aging (GO:0090342)	NEW	6.23	0.006	CDKN2A, TP53
positive regulation of cell aging (GO:0090343)	NEW	7.78	0.002	CDKN2A, TP53
chromatin assembly (GO:0031497)	-	6.55	0.005	CDKN2A, TP53
negative regulation of cellular metabolic process (GO:0031324)	-	2.01	0.04	CHEK2, CDKN2A, TP53
negative regulation of binding (GO:0051100)	NEW	4.85	0.037	CDKN2A, CHEK2, TP53
palate development (GO:0060021)	NEW	5.38	0.02	CDKN2A, CHEK2, TP53
protein stabilization (GO:0050821)	-	4.86	0.017	CHEK2, CDKN2A, TP53
spindle assembly involved in mitosis (GO:0090307)	NEW	6.17	0.02	CHEK2, TP53
cell cycle process (GO:0022402)	-	2.75	0.005	CDKN2A, CHEK2, TP53
positive regulation of muscle cell apoptotic process (GO:0010661)	NEW	7.09	0.029	CDKN2A, TP53
regulation of muscle cell apoptotic process (GO:0010660)	NEW	5.94	0.014	CDKN2A, TP53
trigeminal nerve development (GO:0021559)	NEW	8.34	0.002	CHEK2, TP53
negative regulation of protein serine/threonine kinase activity (GO:0071901)	NEW	4.92	0.041	CDKN2A, CHEK2, TP53
mitotic G2/M transition checkpoint (GO:0044818)	NEW	6.84	0.05	CDKN2A, TP53
negative regulation of macromolecule metabolic process (GO:0010605)	-	2.01	0.038	CHEK2, CDKN2A, TP53
detection of temperature stimulus (GO:0016048)	NEW	6.9	0.044	CHEK2, TP53
DNA integrity checkpoint (GO:0031570)	-	5.25	0.012	CDKN2A, CHEK2, TP53
negative regulation of transferase activity (GO:0051348)	-	3.87	0.009	CHEK2, CDKN2A, TP53
regulation of cell cycle process (GO:0010564)	-	3.5	0.045	CHEK2, CDKN2A, TP53
protein polyubiquitination (GO:0000209)	NEW	4.23	0.027	CDKN2A, CHEK2, TP53
regulation of protein sumoylation (GO:0033233)	NEW	6.68	0.05	CDKN2A, TP53
microtubule cytoskeleton organization involved in mitosis (GO:1902850)	NEW	6.17	0.029	CHEK2, TP53
response to gamma radiation (GO:0010332)	-	5.78	0.024	CHEK2, TP53
negative regulation of protein kinase activity (GO:0006469)	NEW	4.29	0.003	CDKN2A, CHEK2, TP53
regulation of DNA metabolic process (GO:0051052)	-	3.87	0.007	CHEK2, CDKN2A, TP53
negative regulation of phosphate metabolic process (GO:0045936)	NEW	3.45	0.049	CHEK2, CDKN2A, TP53
cellular senescence (GO:0090398)	-	6.26	0.008	CDKN2A, TP53
cell cycle arrest (GO:0007050)	-	4.69	0.001	CDKN2A, TP53
regulation of cell cycle phase transition (GO:1901987)	-	4.15	0.007	CDKN2A, CHEK2, TP53
negative regulation of DNA replication (GO:0008156)	NEW	6.17	0.016	CHEK2, TP53
cellular protein catabolic process (GO:0044257)	NEW	6.51	0.044	CHEK2, TP53
aging (GO:0007568)	-	4.16	0.005	CDKN2A, CHEK2, TP53
adult feeding behavior (GO:0008343)	NEW	7.43	0.017	CHEK2, TP53
signal transduction in response to DNA damage (GO:0042770)	-	5.15	0.01	CHEK2, CDKN2A, TP53
positive regulation of leukocyte apoptotic process (GO:2000108)	-	6.33	0.007	CDKN2A, TP53
apoptotic mitochondrial changes (GO:0008637)	NEW	5.7	0.04	CDKN2A, TP53
negative regulation of phosphorylation (GO:0042326)	NEW	3.7	0.025	CHEK2, CDKN2A, TP53
DNA damage checkpoint (GO:0000077)	-	5.37	0.008	CDKN2A, CHEK2, TP53
cell aging (GO:0007569)	-	5.54	0.0	CHEK2, CDKN2A, TP53
cell cycle checkpoint (GO:0000075)	-	4.79	0.002	CDKN2A, CHEK2, TP53
regulation of cell cycle (GO:0051726)	-	2.93	0.003	CHEK2, CDKN2A, TP53
negative regulation of phosphorus metabolic process (GO:0010563)	NEW	3.45	0.049	CHEK2, CDKN2A, TP53
replicative senescence (GO:0090399)	-	7.24	0.0	CDKN2A, CHEK2, TP53
regulation of cellular response to stress (GO:0080135)	-	3.4	0.024	CDKN2A, TP53
chromatin assembly or disassembly (GO:0006333)	-	5.52	0.037	CDKN2A, TP53
dorsal spinal cord development (GO:0021516)	NEW	7.78	0.011	CHEK2, TP53
negative regulation of cell cycle (GO:0045786)	-	3.67	0.007	CHEK2, CDKN2A, TP53
mitotic G2 DNA damage checkpoint (GO:0007095)	NEW	7.24	0.034	CDKN2A, TP53
negative regulation of protein phosphorylation (GO:0001933)	NEW	3.79	0.012	CHEK2, CDKN2A, TP53

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
intracellular organelle part (GO:0044446)	0.81	3	CDKN2A, CHEK2, TP53
nuclear body (GO:0016604)	3.94	3	CHEK2, CDKN2A, TP53
intracellular membrane-bounded organelle (GO:0043231)	0.6	3	CHEK2, CDKN2A, TP53
nucleus (GO:0005634)	1.07	3	CDKN2A, CHEK2, TP53
cell part (GO:0044464)	0.11	3	CHEK2, CDKN2A, TP53
cytoplasmic part (GO:0044444)	0.82	3	CHEK2, CDKN2A, TP53
nucleoplasm (GO:0005654)	1.89	3	CHEK2, CDKN2A, TP53
intracellular organelle (GO:0043229)	0.51	3	CHEK2, CDKN2A, TP53
nucleoplasm part (GO:0044451)	3.22	3	CHEK2, CDKN2A, TP53
intracellular part (GO:0044424)	0.28	3	CHEK2, CDKN2A, TP53
nuclear part (GO:0044428)	1.55	3	CHEK2, CDKN2A, TP53
chromosomal part (GO:0044427)	3.18	3	CHEK2, CDKN2A, TP53
membrane-bounded organelle (GO:0043227)	0.47	3	CHEK2, CDKN2A, TP53
organelle (GO:0043226)	0.4	3	CHEK2, CDKN2A, TP53
organelle part (GO:0044422)	0.79	3	CDKN2A, CHEK2, TP53
cytoplasm (GO:0005737)	1.01	2	CDKN2A, TP53
protein complex (GO:0043234)	1.51	2	CDKN2A, TP53
PML body (GO:0016605)	5.24	2	CHEK2, TP53
macromolecular complex (GO:0032991)	1.35	2	CDKN2A, TP53
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	2	CDKN2A, TP53
nucleolus (GO:0005730)	3.06	2	CDKN2A, TP53
cytosol (GO:0005829)	1.68	2	CDKN2A, TP53
mitochondrion (GO:0005739)	2.42	2	CDKN2A, TP53
non-membrane-bounded organelle (GO:0043228)	1.76	2	CDKN2A, TP53
chromatin (GO:0000785)	3.99	2	CDKN2A, TP53

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
nucleoplasm (GO:0005654)	-	1.89	0.027	CHEK2, CDKN2A, TP53
PML body (GO:0016605)	-	5.24	0.004	CHEK2, TP53
spindle (GO:0005819)	NEW	4.52	0.006	CDKN2A, CHEK2, TP53
cytoplasmic microtubule (GO:0005881)	NEW	5.74	0.041	CDKN2A, TP53
chromatin (GO:0000785)	-	3.99	0.049	CDKN2A, TP53
germ cell nucleus (GO:0043073)	NEW	6.76	0.015	CHEK2, TP53
nucleolar part (GO:0044452)	NEW	5.68	0.02	CDKN2A, TP53