Disease table of RUBINSTEIN-TAYBI SYNDROME OMIM ID: PS180849

Gene-disease associations table

GeneAssociated with RUBINSTEIN-TAYBI SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
EP300ClinVar, OMIMHGNC link22q13.22114500, PS180849
CREBBPClinVar, OMIM, HUMSAVARHGNC link16p13.32PS142623, PS180849

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
EP300YES56ALOX15, PCNA, MDM2, VCAM1, EIF2AK1, PTGS2, BIRC5, IFNG, EPO, PARP1, TBXAS1, BGLAP, CDKN2B, IL12B, RS1, LDHA, CCNE1, ABCB1, TP73, KLF5, LAMA3, HINFP, THBD, ERBB2, DNMT1, BRCA1, WT1, CCNB2, CDKN1A, ZEB1, GFAP, TRIM22, SPP1, CYBB, RELA, NPAS2, CXCL8, VEGFA, NFKB1, CRABP1, CA9, NR0B2, NR1H4, CREBBP, CLOCK, IGFBP3, IL5, IL6, SLC9A2, MMP9, IGF1, KRT16, MYC, CCND1, PML, RAD511CREBBP
CREBBPYES27ALOX15, CLOCK, CSF2, TP53, CREB1, EGFR, PTGS2, IL4, LDHA, INSM1, HOXA9, CCK, ONECUT1, BRCA1, PPARA, RS1, CDKN1A, RARA, TRIM22, NPAS2, EP300, PCK2, HOXA10, IRF1, PSMC5, HINFP, RAD511EP300
MYCNO102CBFB, PRDX3, CHKA, ATF3, CDK4, PCNA, CEBPA, LDHA, DKK1, MTDH, TFAP4, HLA-G, CDC25A, UBE2C, HLA-B, GATA1, TP53, BAG2, PMAIP1, CDK6, WRN, PGK1, TFAM, IGK, JUNB, ZFP36, HNRNPA1, MYB, SART3, EBNA1BP2, TOP1MT, ST3GAL4, CD33, CCND2, PTBP1, CDCA7, RB1, CCNA2, HLA-C, CYP3A4, FMR1, TERT, NFE2, MME, NDRG1, HDAC2, BRD7, FASLG, CCNB1, TP73, RCC1, SFRP1, HLA-F, CFLAR, BCAT1, CD38, TFRC, CCND1, MTA1, KRAS, HNRNPA2B1, CDC34, ST3GAL3, HLA-A, FUT3, NOL7, FTH1P18, VEGFA, EP300, CDK2, ASS1, SURF1, CDC25C, IER3, ST3GAL1, FOXM1, HSPA4, XPO1, CAD, SHMT1, DDX18, IGF2BP1, BMI1, IPO7, BCL2, CXCR4, SRSF1, TLX1, PRODH, NBN, CDKN1A, IFNA1, TNFRSF10B, ID2, CCNE1, SURF2, HLA-E, CREBBP, MAPK1, IL6, EIF4E, ODC12CREBBP, EP300
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
EP300YES7CREBBP, AR, NUPR1, EGR1, PML, MYC, BRCA11CREBBP
CREBBPYES7YY1, CLOCK, BCL11B, CIITA, MYC, EP300, E2F11EP300
HINFPNO2CREBBP, EP3002CREBBP, EP300
CLOCKNO4KAT2B, EP300, CREBBP, NCOA32CREBBP, EP300
CDKN1ANO118ABL1, TFAP4, TP53, MYF5, TCF3, HDAC9, PAX5, ZBTB2, LCOR, E2F3, ZBTB5, HSF1, ELL, TSC22D3, NCOA1, TAF1, RELA, MYOD1, STAT1, PTTG1, KLF16, ESR1, JUNB, MYCN, KAT2B, AR, BCL6, KLF10, EZH2, ARID1A, JUND, SP1, CEBPB, ZFHX3, ZNF300, EGR1, KLF4, AATF, HDAC7, HBP1, SMARCA4, ESR2, FOXP3, RARA, NELFCD, ING4, HDAC4, TBX2, IRF1, HDAC2, ETV6, SIRT2, MYOG, KLF6, TP73, SOX6, ATM, ERCC2, SMAD4, ETS2, NUPR1, PTMA, MLLT10, SMAD3, ETS1, CBX8, BRCA1, HIPK2, SIRT1, WT1, ZNF76, HDAC1, SMAD2, MLLT3, TFAP2A, EP300, FHL2, TP63, IRF9, EHMT2, TFAP2C, NFIX, RUNX3, RB1, HNF4A, NFIB, TAF5, SOX9, TBP, EAPP, ZBTB17, TAF4, REL, RELB, PML, SMAD7, NPM1, POU5F1, E2F1, TBX3, FOXG1, MYF6, NFIA, ATF2, PARP1, NFKB1, STAT3, GFI1, NR3C1, CREBBP, MTA1, JUN, KLF2, CDX2, SP3, MYC, PPARG, ING12CREBBP, EP300
ALOX15NO4STAT6, CREBBP, EP300, SPI12CREBBP, EP300
RS1NO3CRX, EP300, CREBBP2CREBBP, EP300
NPAS2NO4KAT2B, EP300, CREBBP, NCOA32CREBBP, EP300
BRCA1NO33WWP1, RBL2, EZH2, DLX4, CTBP1, SP1, E2F4, ID4, NCOA3, USF2, MTA1, E2F1, FOSL2, RBL1, FOXP3, IFI16, NFE2L2, SP100, TP53, CTCF, EP300, ETS1, E2F6, NR3C1, YY1, JUN, TP53BP1, RB1, HMGA1, ESR1, AHR, CREBBP, FOXA12CREBBP, EP300
TRIM22NO4IRF1, EP300, CREBBP, TP532CREBBP, EP300
PTGS2NO41AR, ING4, TFAP2A, TCF7L2, CREB1, PGR, JUND, FOS, NFATC4, SP1, ETV4, STAT2, EGR1, STAT6, USF2, DR1, CTNNB1, HMGA1, PPARA, APC, EP300, HDAC1, STAT3, ATF2, JUN, RELA, HDAC4, SETBP1, NFKB1, STAT1, ELF3, NR0B2, CREBBP, NFIL3, CDX1, CEBPB, CEBPD, CDX2, JUNB, PPARG, USF12CREBBP, EP300
LDHANO9SP1, HSF1, CREBBP, CREB1, JUN, ATF1, MYC, EP300, HIF1A2CREBBP, EP300
RAD51NO4CREBBP, EP300, RBL2, E2F42CREBBP, EP300
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
EP300CREBBPYes179DDX5, TGS1, NCOA6, PCNA, TDG, MYBL2, TP53, MYOD1, TCF3, KLF2, RUNX1, KLF13, NCOA3, KAT6A, C3ORF62, PIAS3, NR3C2, SS18L1, FHL2, CTNNB1, FOXO3, BCL6, FOSB, FHL1, TRIP4, SMARCA2, NFYB, JUN, GATA1, ETS2, AKT1, EPAS1, TACC2, STAT1, CDK2, ANAPC2, YY1, CLOCK, CRTC1, KPNA2, POLR2A, NUP98, ESR1, JUNB, IRF3, KAT2B, MDC1, HIST3H3, RUNX2, KLF1, HBP1, HOXD10, MYB, EWSR1, HIST1H3A, KAT5, SP1, CITED1, CARM1, EGR1, FOS, KLF4, EID1, NFATC2, HDAC3, NCOR1, NCOA2, TCF12, PLAGL1, PPARGC1A, MAML2, ESR2, MED23, RARA, CDH1, KLF8, ETS1, IRF1, HHV8GK18_GP81, SNIP1, SMAD1, TP73, HIF1A, PELP1, ATF4, AR, SMAD4, NPAS2, FOSL1, IRF7, ARNTL, HIST4H4, TBX21, STAT6, CHUK, FOXO1, GTF2B, VIRF-3, KLF5, CREB1, SERTAD1, BMI1, PTMA, SMAD3, BRMS1, BRCA1, HIPK2, ELK1, CCNA2, ANAPC5, ACTA2, SNAI1, HDAC1, STAT3, SMAD2, PPP1R13L, EP300, GRIP1, E2F1, MGMT, UBE2D1, CDC20, WDR5, N4BP2, XRCC6, MAP3K5, CEBPB, HIST1H2BB, ZEB1, COPS2, MAML1, SREBF2, PTMS, IRF5, MDM2, TBP, MAPK1, HCVGP1, DDIT3, SETD1A, CDC16, RPS6KA5, HOXD4, DYRK1B, REL, CTBP1, TAT, HIST1H4A, STAT2, SREBF1, CITED2, NCOR2, SRCAP, DEK, TRERF1, CDKN1A, VDR, VIRF-1, HIST2H2BE, ATF2, PARP1, HNF1A, MSH6, ATXN3, MYC, ANAPC7, NR3C1, DDX17, MAF, CREBBP, RELA, CEBPD, MTF1, DYRK1A, SP3, NCOA1, UBE2I, PPARG, ING1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
EP300CREBBPNo8RELA, TCF3, TP53, CTNNB1, MYOD1, BRCA1, STAT6, NEUROG1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
EP300CREBBPYesbinding281IRF2, KRT14, AKT1, NCOA6, FABP1, GTF3A, TP53, MYOD1, ME1, MAML3, MED15, CREB3L4, MED8, RUNX1, VEGFA, FABP4, HES5, FOXO3, ETS2, CSF2, KAT6A, LPL, MTF1, PPARD, NCOA3, HDAC7, IRF7, CDK8, ARNT, ADIPOQ, EDN1, ANAPC5, CREB3L1, MAPK14, PPARA, CAMK2G, BAX, IFNB1, NCOA2, CREB5, MYBL2, TFDP1, E2F5, HES1, SMARCA2, COL4A6, NFYB, MED29, MED11, SMAD4, RELA, EPAS1, TFDP2, HNF1A, E2F1, MED19, CREB3L3, CA9, PITX2, CD36, YY1, TERT, FOSL1, APOA2, POLR2A, HSD17B4, NCL, MAML2, ANGPTL4, JUNB, PRKACB, TGS1, IRF9, IRF3, KAT2B, MYC, AR, NRIP1, SRA1, RUNX2, HDAC9, MED10, PLIN1, CDKN1A, IL8, PRKX, EPO, TCF7L2, MYB, NR1H3, BDKRB2, APOA1, UBB, MED27, HIF3A, SP1, CITED1, CCND2, SPI1, CAMK2A, FOS, KLF4, MED13, TCF3, CCNC, FOXO4, IL1B, HDAC5, MYF6, HIST1H1E, NOTCH1, PPARGC1A, ESR1, ESR2, MED23, HDAC10, DEDD2, MAX, RARA, MED25, ETS1, CNTN2, TCF7, CEBPA, CABIN1, CAMK4, PRKACG, SNIP1, GADD45A, MED21, RAC3, SERPINH1, UBC, SMARCA4, MEF2C, HEY1, SKIL, PELP1, MED24, ATF4, CDK19, NFYA, CRYBA4, HIST1H3A, UBE2D1, SRC, SLC2A1, PTGES2, ARNTL, CAMK2B, HDAC2, KAT5, CRTC2, NCOR1, STAT5B, MEF2A, MRPL18, FOXO1, EHHADH, GCK, EIF2S1, CCND1, KLF5, MED31, STAT5A, CREB1, PRMT1, PTMA, SMAD3, MED12, SMARCD3, GLI3, BRCA1, HIPK2, H2AFZ, CITED2, MED17, CTNNB1, LEF1, DNAJB1, CREB3, TCF7L1, FKBP4, SMAD2, MED1, PRKACA, CPT1A, CAMK2D, LEP, GRIP1, MED13L, FOXM1, FHL2, MED14, CDK2, GML, STAT6, MED4, NFATC2, RBPJ, CEBPB, RB1, HSPA6, GTF2F1, MAML1, SREBF2, MED7, NCOA1, MDM2, TBP, JMY, MED26, MED16, RPS6KA5, HELZ2, CCNE2, GTF2A1, ODC1, JUN, CTBP1, REL, HIST1H4A, MED20, NPAS2, LDHA, STAT2, GTF2E1, SREBF1, TP73, TNFRSF21, MEF2D, THRB, GTF2B, NCOR2, CHD9, SKP2, MYBL1, HDAC3, IRF1, SRCAP, HDAC1, RXRG, MED9, THRA, VDR, CREB3L2, MED30, ACOX1, BNIP3L, SMAD1, JUP, MED18, TRERF1, ATF2, SNW1, NR4A1, PARP1, CARM1, MUC2, NFKB1, HEYL, MED6, STAT3, NMI, HSPA8, EGR1, NR3C1, BCL2, STAT4, SNAPC4, RBPJL, RLN1, HEY2, PCK1, HIF1A, PPARG, HSPH1, DNAJB6, MAF, PML, SGK1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
EP300CREBBPYesp300-CBP-p270 complex;p300-CBP-p270-SWI/SNF complex;Multisubunit ACTR coactivator complex;HES1 promoter corepressor complex17SMARCC1, KAT2B, RBPJ, SMARCA4, TCF4, SMARCB1, NCOA3, POLR2A, CDK8, SMAD1, SMARCC2, SMAD3, SUPT6H, CTNNB1, MYOD1, ARID1A, CDK7

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
EP300CREBBPNo1TP53

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Renal cell carcinomahsa052116.62CREBBP, EP300
cAMP signaling pathwayhsa040245.052CREBBP, EP300
Prostate cancerhsa052156.112CREBBP, EP300
Long-term potentiationhsa047206.642CREBBP, EP300
FoxO signaling pathwayhsa040685.632CREBBP, EP300
HIF-1 signaling pathwayhsa040665.92CREBBP, EP300
Thyroid hormone signaling pathwayhsa049195.822CREBBP, EP300
Notch signaling pathwayhsa043307.122CREBBP, EP300
Herpes simplex infectionhsa051685.082CREBBP, EP300
Epstein-Barr virus infectionhsa051694.972CREBBP, EP300
Influenza Ahsa051645.212CREBBP, EP300
HTLV-I infectionhsa051664.592CREBBP, EP300
Wnt signaling pathwayhsa043105.492CREBBP, EP300
Hepatitis Bhsa051615.522CREBBP, EP300
TGF-beta signaling pathwayhsa043506.412CREBBP, EP300
Cell cyclehsa041105.682CREBBP, EP300
MicroRNAs in cancerhsa052065.382CREBBP, EP300
Pathways in cancerhsa052003.982CREBBP, EP300
Viral carcinogenesishsa052035.082CREBBP, EP300
Adherens junctionhsa045206.262CREBBP, EP300
Melanogenesishsa049165.972CREBBP, EP300
Jak-STAT signaling pathwayhsa046305.442CREBBP, EP300
Tuberculosishsa051525.172CREBBP, EP300
Huntington's diseasehsa050165.172CREBBP, EP300

NET-GE enrichment

Term New enriched termICP valueGenes
Renal cell carcinoma (hsa05211) -6.60.021CREBBP, EP300
cAMP signaling pathway (hsa04024) -5.050.036CREBBP, EP300
Jak-STAT signaling pathway (hsa04630) -5.440.021CREBBP, EP300
Long-term potentiation (hsa04720) -6.640.004CREBBP, EP300
FoxO signaling pathway (hsa04068) -5.630.016CREBBP, EP300
HIF-1 signaling pathway (hsa04066) -5.90.011CREBBP, EP300
Thyroid hormone signaling pathway (hsa04919) -5.820.012CREBBP, EP300
Notch signaling pathway (hsa04330) -7.120.006CREBBP, EP300
Herpes simplex infection (hsa05168) -5.080.034CREBBP, EP300
Epstein-Barr virus infection (hsa05169) -4.970.04CREBBP, EP300
Influenza A (hsa05164) -5.210.028CREBBP, EP300
Wnt signaling pathway (hsa04310) -5.490.019CREBBP, EP300
Hepatitis B (hsa05161) -5.520.018CREBBP, EP300
TGF-beta signaling pathway (hsa04350) -6.410.005CREBBP, EP300
MicroRNAs in cancer (hsa05206) -5.380.023CREBBP, EP300
Cell cycle (hsa04110) -5.680.05CREBBP, EP300
Inflammatory bowel disease (IBD) (hsa05321) NEW6.430.028CREBBP, EP300
Viral carcinogenesis (hsa05203) -5.080.034CREBBP, EP300
Adherens junction (hsa04520) -6.260.007CREBBP, EP300
Melanogenesis (hsa04916) -5.970.01CREBBP, EP300
Acute myeloid leukemia (hsa05221) NEW6.740.015CREBBP, EP300
Chronic myeloid leukemia (hsa05220) NEW6.480.022CREBBP, EP300
Prostate cancer (hsa05215) -6.110.008CREBBP, EP300
Bile secretion (hsa04976) NEW6.560.033CREBBP, EP300
Maturity onset diabetes of the young (hsa04950) NEW8.070.005CREBBP, EP300
Tuberculosis (hsa05152) -5.170.03CREBBP, EP300
Huntington's disease (hsa05016) -5.170.03CREBBP, EP300
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Transcriptional regulation of white adipocyte differentiationR-HSA-3813406.72CREBBP, EP300
Immune SystemR-HSA-1682562.372CREBBP, EP300
Signaling by NOTCHR-HSA-1571186.22CREBBP, EP300
MetabolismR-HSA-14307282.342CREBBP, EP300
Fatty acid, triacylglycerol, and ketone body metabolismR-HSA-5357345.442CREBBP, EP300
Factors involved in megakaryocyte development and platelet productionR-HSA-9832315.882CREBBP, EP300
DiseaseR-HSA-16436853.332CREBBP, EP300
PPARA activates gene expressionR-HSA-19897816.182CREBBP, EP300
TRAF3-dependent IRF activation pathwayR-HSA-9182339.182CREBBP, EP300
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)R-HSA-4002066.142CREBBP, EP300
RORA activates gene expressionR-HSA-13680828.232CREBBP, EP300
Cellular responses to stressR-HSA-22627524.562CREBBP, EP300
HATs acetylate histonesR-HSA-32148476.232CREBBP, EP300
Attenuation phaseR-HSA-33715689.282CREBBP, EP300
Developmental BiologyR-HSA-12667383.482CREBBP, EP300
Metabolism of lipids and lipoproteinsR-HSA-5568333.792CREBBP, EP300
HemostasisR-HSA-1095823.982CREBBP, EP300
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsR-HSA-28948627.152CREBBP, EP300
C-type lectin receptors (CLRs)R-HSA-56214816.062CREBBP, EP300
TRAF6 mediated IRF7 activationR-HSA-9335417.982CREBBP, EP300
Regulation of gene expression by Hypoxia-inducible FactorR-HSA-12341589.812CREBBP, EP300
Diseases of signal transductionR-HSA-56632024.892CREBBP, EP300
Signaling by NOTCH1R-HSA-19801436.812CREBBP, EP300
Innate Immune SystemR-HSA-1682493.172CREBBP, EP300
Regulation of Hypoxia-inducible Factor (HIF) by oxygenR-HSA-12341748.42CREBBP, EP300
HSF1-dependent transactivationR-HSA-33715718.592CREBBP, EP300
Signaling by WntR-HSA-1957214.792CREBBP, EP300
NOTCH1 Intracellular Domain Regulates TranscriptionR-HSA-21229477.432CREBBP, EP300
Cytosolic sensors of pathogen-associated DNA R-HSA-18349496.942CREBBP, EP300
Pre-NOTCH Expression and ProcessingR-HSA-19124227.492CREBBP, EP300
BMAL1:CLOCK,NPAS2 activates circadian gene expressionR-HSA-13681087.592CREBBP, EP300
Chromatin modifying enzymesR-HSA-32475095.192CREBBP, EP300
Circadian ClockR-HSA-4002537.032CREBBP, EP300
Cellular response to hypoxiaR-HSA-22627498.42CREBBP, EP300
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN productionR-HSA-313497310.662CREBBP, EP300
formation of the beta-catenin:TCF transactivating complexR-HSA-2017227.182CREBBP, EP300
Signaling by NOTCH1 in CancerR-HSA-26446037.152CREBBP, EP300
Signaling by NOTCH1 PEST Domain Mutants in CancerR-HSA-26446027.152CREBBP, EP300
Constitutive Signaling by NOTCH1 PEST Domain MutantsR-HSA-26446067.152CREBBP, EP300
CD209 (DC-SIGN) signalingR-HSA-56215758.592CREBBP, EP300
Cellular response to heat stressR-HSA-33715566.592CREBBP, EP300
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerR-HSA-28948587.152CREBBP, EP300
Chromatin organizationR-HSA-48397265.192CREBBP, EP300
TCF dependent signaling in response to WNTR-HSA-2016815.362CREBBP, EP300
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysR-HSA-1689286.72CREBBP, EP300
Pre-NOTCH Transcription and TranslationR-HSA-19124088.122CREBBP, EP300
Signal TransductionR-HSA-1625821.782CREBBP, EP300

NET-GE enrichment

Term New enriched termICP valueGenes
Regulation of gene expression in beta cells (R-HSA-210745) NEW8.660.003CREBBP, EP300
Oxidative Stress Induced Senescence (R-HSA-2559580) NEW6.510.042CREBBP, EP300
Transcriptional regulation of white adipocyte differentiation (R-HSA-381340) -6.70.024CREBBP, EP300
Signaling by NOTCH (R-HSA-157118) -6.20.012CREBBP, EP300
Mitochondrial biogenesis (R-HSA-1592230) NEW7.340.022CREBBP, EP300
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways (R-HSA-168928) -6.70.006CREBBP, EP300
deactivation of the beta-catenin transactivating complex (R-HSA-3769402) NEW7.590.009CREBBP, EP300
Fatty acid, triacylglycerol, and ketone body metabolism (R-HSA-535734) -5.440.034CREBBP, EP300
Factors involved in megakaryocyte development and platelet production (R-HSA-983231) -5.880.018CREBBP, EP300
PPARA activates gene expression (R-HSA-1989781) -6.180.012CREBBP, EP300
TRAF3-dependent IRF activation pathway (R-HSA-918233) -9.180.0CREBBP, EP300
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (R-HSA-400206) -6.140.013CREBBP, EP300
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168) NEW7.620.006CREBBP, EP300
HATs acetylate histones (R-HSA-3214847) -6.230.041CREBBP, EP300
Attenuation phase (R-HSA-3371568) -9.280.0CREBBP, EP300
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (R-HSA-2894862) -7.150.014CREBBP, EP300
Signaling by Retinoic Acid (R-HSA-5362517) NEW7.620.009CREBBP, EP300
C-type lectin receptors (CLRs) (R-HSA-5621481) -6.060.014CREBBP, EP300
TRAF6 mediated IRF7 activation (R-HSA-933541) -7.980.001CREBBP, EP300
Regulation of gene expression by Hypoxia-inducible Factor (R-HSA-1234158) -9.810.0CREBBP, EP300
RORA activates gene expression (R-HSA-1368082) -8.230.001CREBBP, EP300
Diseases associated with visual transduction (R-HSA-2474795) NEW9.280.002CREBBP, EP300
Aquaporin-mediated transport (R-HSA-445717) NEW7.310.012CREBBP, EP300
Regulation of Hypoxia-inducible Factor (HIF) by oxygen (R-HSA-1234174) -8.40.001CREBBP, EP300
TCF dependent signaling in response to WNT (R-HSA-201681) -5.360.038CREBBP, EP300
Signaling by NOTCH1 (R-HSA-1980143) -6.810.027CREBBP, EP300
NOTCH1 Intracellular Domain Regulates Transcription (R-HSA-2122947) -7.430.002CREBBP, EP300
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949) -6.940.024CREBBP, EP300
The canonical retinoid cycle in rods (twilight vision) (R-HSA-2453902) NEW8.520.005CREBBP, EP300
Pre-NOTCH Expression and Processing (R-HSA-1912422) -7.490.002CREBBP, EP300
Transcriptional activation of mitochondrial biogenesis (R-HSA-2151201) NEW7.620.012CREBBP, EP300
BMAL1:CLOCK,NPAS2 activates circadian gene expression (R-HSA-1368108) -7.590.002CREBBP, EP300
Chromatin modifying enzymes (R-HSA-3247509) -5.190.048CREBBP, EP300
Circadian Clock (R-HSA-400253) -7.030.004CREBBP, EP300
Cellular response to hypoxia (R-HSA-2262749) -8.40.001CREBBP, EP300
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production (R-HSA-3134973) -10.660.0CREBBP, EP300
formation of the beta-catenin:TCF transactivating complex (R-HSA-201722) -7.180.01CREBBP, EP300
Regulation of beta-cell development (R-HSA-186712) NEW7.980.01CREBBP, EP300
Regulation of cholesterol biosynthesis by SREBP (SREBF) (R-HSA-1655829) NEW7.230.011CREBBP, EP300
Signaling by NOTCH1 in Cancer (R-HSA-2644603) -7.150.014CREBBP, EP300
Signaling by NOTCH1 PEST Domain Mutants in Cancer (R-HSA-2644602) -7.150.014CREBBP, EP300
Constitutive Signaling by NOTCH1 PEST Domain Mutants (R-HSA-2644606) -7.150.014CREBBP, EP300
CD209 (DC-SIGN) signaling (R-HSA-5621575) -8.590.002CREBBP, EP300
Cellular response to heat stress (R-HSA-3371556) -6.590.007CREBBP, EP300
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (R-HSA-2894858) -7.150.014CREBBP, EP300
Chromatin organization (R-HSA-4839726) -5.190.048CREBBP, EP300
Degradation of beta-catenin by the destruction complex (R-HSA-195253) NEW6.640.022CREBBP, EP300
HSF1-dependent transactivation (R-HSA-3371571) -8.590.001CREBBP, EP300
Pre-NOTCH Transcription and Translation (R-HSA-1912408) -8.120.003CREBBP, EP300
Retinoid cycle disease events (R-HSA-2453864) NEW9.280.002CREBBP, EP300
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
zinc ion binding (GO:0008270) 2.662CREBBP, EP300
peptide N-acetyltransferase activity (GO:0034212) 5.552CREBBP, EP300
activating transcription factor binding (GO:0033613) 5.682CREBBP, EP300
transcription coactivator activity (GO:0003713) 4.042CREBBP, EP300
peptide-lysine-N-acetyltransferase activity (GO:0061733) 5.682CREBBP, EP300
macromolecular complex binding (GO:0044877) 2.612CREBBP, EP300
binding (GO:0005488) 0.182CREBBP, EP300
nucleic acid binding (GO:0003676) 1.442CREBBP, EP300
DNA binding (GO:0003677) 1.922CREBBP, EP300
bHLH transcription factor binding (GO:0043425) 6.412CREBBP, EP300
heterocyclic compound binding (GO:1901363) 1.062CREBBP, EP300
sequence-specific DNA binding (GO:0043565) 2.792CREBBP, EP300
sequence-specific double-stranded DNA binding (GO:1990837) 3.22CREBBP, EP300
N-acetyltransferase activity (GO:0008080) 5.272CREBBP, EP300
histone acetyltransferase activity (GO:0004402) 5.72CREBBP, EP300
transcription cofactor activity (GO:0003712) 3.442CREBBP, EP300
ion binding (GO:0043167) 1.362CREBBP, EP300
transferase activity (GO:0016740) 1.952CREBBP, EP300
transferase activity, transferring acyl groups (GO:0016746) 4.22CREBBP, EP300
transferase activity, transferring acyl groups other than amino-acyl groups (GO:0016747) 4.372CREBBP, EP300
transcription factor activity, transcription factor binding (GO:0000989) 3.362CREBBP, EP300
transcription factor activity, protein binding (GO:0000988) 3.352CREBBP, EP300
core promoter proximal region sequence-specific DNA binding (GO:0000987) 3.832CREBBP, EP300
double-stranded DNA binding (GO:0003690) 3.092CREBBP, EP300
metal ion binding (GO:0046872) 1.412CREBBP, EP300
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.292CREBBP, EP300
N-acyltransferase activity (GO:0016410) 5.082CREBBP, EP300
cation binding (GO:0043169) 1.42CREBBP, EP300
transcription factor binding (GO:0008134) 3.462CREBBP, EP300
regulatory region nucleic acid binding (GO:0001067) 3.032CREBBP, EP300
SMAD binding (GO:0046332) 5.452CREBBP, EP300
catalytic activity (GO:0003824) 1.052CREBBP, EP300
core promoter proximal region DNA binding (GO:0001159) 3.822CREBBP, EP300
RNA polymerase II activating transcription factor binding (GO:0001102) 6.132CREBBP, EP300
RNA polymerase II transcription factor binding (GO:0001085) 5.082CREBBP, EP300
transcription regulatory region DNA binding (GO:0044212) 3.032CREBBP, EP300
transition metal ion binding (GO:0046914) 2.482CREBBP, EP300
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.652CREBBP, EP300
organic cyclic compound binding (GO:0097159) 1.052CREBBP, EP300
acetyltransferase activity (GO:0016407) 5.12CREBBP, EP300
transcription regulatory region sequence-specific DNA binding (GO:0000976) 3.242CREBBP, EP300
protein binding (GO:0005515) 0.462CREBBP, EP300
regulatory region DNA binding (GO:0000975) 3.032CREBBP, EP300
peroxisome proliferator activated receptor binding (GO:0042975) 7.032CREBBP, EP300
receptor binding (GO:0005102) 2.432CREBBP, EP300
chromatin binding (GO:0003682) 3.642CREBBP, EP300
p53 binding (GO:0002039) 5.532CREBBP, EP300
damaged DNA binding (GO:0003684) 5.582CREBBP, EP300
nucleic acid binding transcription factor activity (GO:0001071) 2.652CREBBP, EP300

NET-GE enrichment

Term New enriched termICP valueGenes
core promoter binding (GO:0001047) NEW4.710.05CREBBP, EP300
activating transcription factor binding (GO:0033613) -5.680.01CREBBP, EP300
transcription coactivator activity (GO:0003713) -4.040.017CREBBP, EP300
enhancer sequence-specific DNA binding (GO:0001158) NEW5.360.023CREBBP, EP300
chromatin DNA binding (GO:0031490) NEW5.370.01CREBBP, EP300
bHLH transcription factor binding (GO:0043425) -6.410.002CREBBP, EP300
E-box binding (GO:0070888) NEW6.210.002CREBBP, EP300
RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription (GO:0001190) NEW5.770.007CREBBP, EP300
N-acetyltransferase activity (GO:0008080) -5.270.012CREBBP, EP300
chromatin binding (GO:0003682) -3.640.037CREBBP, EP300
histone acetyltransferase activity (GO:0004402) -5.70.003CREBBP, EP300
transferase activity, transferring acyl groups (GO:0016746) -4.20.012CREBBP, EP300
transferase activity, transferring acyl groups other than amino-acyl groups (GO:0016747) -4.370.008CREBBP, EP300
N-acyltransferase activity (GO:0016410) -5.080.001CREBBP, EP300
anion channel activity (GO:0005253) NEW5.230.021CREBBP, EP300
histone deacetylase binding (GO:0042826) NEW5.080.02CREBBP, EP300
steroid hormone receptor binding (GO:0035258) NEW5.320.018CREBBP, EP300
transcription factor binding (GO:0008134) -3.460.045CREBBP, EP300
translation factor activity, nucleic acid binding (GO:0008135) NEW5.070.018CREBBP, EP300
beta-catenin binding (GO:0008013) NEW5.30.017CREBBP, EP300
SMAD binding (GO:0046332) -5.450.015CREBBP, EP300
RNA polymerase II transcription coactivator activity (GO:0001105) NEW6.150.002CREBBP, EP300
RNA polymerase II activating transcription factor binding (GO:0001102) -6.130.0CREBBP, EP300
histone acetyltransferase binding (GO:0035035) NEW6.410.001CREBBP, EP300
translation regulator activity (GO:0045182) NEW6.150.004CREBBP, EP300
core promoter sequence-specific DNA binding (GO:0001046) NEW5.120.019CREBBP, EP300
steroid binding (GO:0005496) NEW5.240.045CREBBP, EP300
HMG box domain binding (GO:0071837) NEW6.850.001CREBBP, EP300
RNA polymerase II transcription factor binding (GO:0001085) -5.080.042CREBBP, EP300
RNA polymerase II transcription cofactor activity (GO:0001104) NEW5.220.029CREBBP, EP300
selenium binding (GO:0008430) NEW7.660.001CREBBP, EP300
retinol binding (GO:0019841) NEW7.170.001CREBBP, EP300
acetyltransferase activity (GO:0016407) -5.10.021CREBBP, EP300
transcription regulatory region sequence-specific DNA binding (GO:0000976) -3.240.022CREBBP, EP300
RNA polymerase II core promoter sequence-specific DNA binding (GO:0000979) NEW5.770.009CREBBP, EP300
p53 binding (GO:0002039) -5.530.008CREBBP, EP300
enhancer binding (GO:0035326) NEW5.210.036CREBBP, EP300
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of primary metabolic process (GO:0080090) 1.082CREBBP, EP300
regulation of metabolic process (GO:0019222) 1.022CREBBP, EP300
protein acetylation (GO:0006473) 4.862CREBBP, EP300
positive regulation of response to stimulus (GO:0048584) 2.182CREBBP, EP300
regulation of response to stimulus (GO:0048583) 1.542CREBBP, EP300
N-terminal protein amino acid acetylation (GO:0006474) 7.022CREBBP, EP300
positive regulation of defense response (GO:0031349) 3.832CREBBP, EP300
signal transduction (GO:0007165) 1.282CREBBP, EP300
cell surface receptor signaling pathway (GO:0007166) 2.092CREBBP, EP300
organic substance biosynthetic process (GO:1901576) 1.342CREBBP, EP300
organic cyclic compound biosynthetic process (GO:1901362) 1.662CREBBP, EP300
cellular component organization or biogenesis (GO:0071840) 1.222CREBBP, EP300
cellular response to stimulus (GO:0051716) 1.972CREBBP, EP300
Notch signaling pathway (GO:0007219) 4.992CREBBP, EP300
negative regulation of macromolecule metabolic process (GO:0010605) 2.012CREBBP, EP300
positive regulation of cell cycle (GO:0045787) 3.942CREBBP, EP300
regulation of signal transduction (GO:0009966) 1.842CREBBP, EP300
peptidyl-amino acid modification (GO:0018193) 2.982CREBBP, EP300
interspecies interaction between organisms (GO:0044419) 3.082CREBBP, EP300
rhythmic process (GO:0048511) 4.022CREBBP, EP300
positive regulation of biological process (GO:0048518) 1.22CREBBP, EP300
negative regulation of biological process (GO:0048519) 1.332CREBBP, EP300
heterocycle metabolic process (GO:0046483) 1.312CREBBP, EP300
histone modification (GO:0016570) 3.912CREBBP, EP300
regulation of macromolecule metabolic process (GO:0060255) 1.082CREBBP, EP300
internal protein amino acid acetylation (GO:0006475) 4.992CREBBP, EP300
response to hypoxia (GO:0001666) 4.132CREBBP, EP300
regulation of RNA biosynthetic process (GO:2001141) 1.552CREBBP, EP300
response to organic substance (GO:0010033) 2.22CREBBP, EP300
multi-organism process (GO:0051704) 2.652CREBBP, EP300
immune response-activating cell surface receptor signaling pathway (GO:0002429) 4.062CREBBP, EP300
protein metabolic process (GO:0019538) 1.452CREBBP, EP300
immune system process (GO:0002376) 2.292CREBBP, EP300
peptidyl-lysine modification (GO:0018205) 3.982CREBBP, EP300
cellular response to stress (GO:0033554) 2.512CREBBP, EP300
aromatic compound biosynthetic process (GO:0019438) 1.72CREBBP, EP300
covalent chromatin modification (GO:0016569) 3.892CREBBP, EP300
cellular component assembly (GO:0022607) 2.142CREBBP, EP300
negative regulation of metabolic process (GO:0009892) 1.932CREBBP, EP300
positive regulation of metabolic process (GO:0009893) 1.742CREBBP, EP300
negative regulation of biosynthetic process (GO:0009890) 2.472CREBBP, EP300
positive regulation of biosynthetic process (GO:0009891) 2.292CREBBP, EP300
cellular response to UV (GO:0034644) 5.522CREBBP, EP300
positive regulation of RNA metabolic process (GO:0051254) 2.512CREBBP, EP300
metabolic process (GO:0008152) 0.582CREBBP, EP300
negative regulation of gene expression (GO:0010629) 2.482CREBBP, EP300
nitrogen compound metabolic process (GO:0006807) 1.132CREBBP, EP300
N-terminal protein amino acid modification (GO:0031365) 6.472CREBBP, EP300
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352CREBBP, EP300
regulation of transcription from RNA polymerase II promoter in response to hypoxia (GO:0061418) 6.262CREBBP, EP300
regulation of biological process (GO:0050789) 0.452CREBBP, EP300
beta-catenin-TCF complex assembly (GO:1904837) 6.332CREBBP, EP300
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.552CREBBP, EP300
cellular protein metabolic process (GO:0044267) 1.632CREBBP, EP300
regulation of mitotic cell cycle (GO:0007346) 3.712CREBBP, EP300
regulation of cell communication (GO:0010646) 1.732CREBBP, EP300
immune response-regulating signaling pathway (GO:0002764) 3.722CREBBP, EP300
cellular macromolecule metabolic process (GO:0044260) 0.932CREBBP, EP300
immune response-regulating cell surface receptor signaling pathway (GO:0002768) 3.962CREBBP, EP300
cellular component organization (GO:0016043) 1.242CREBBP, EP300
macromolecular complex assembly (GO:0065003) 2.552CREBBP, EP300
positive regulation of immune system process (GO:0002684) 2.962CREBBP, EP300
regulation of immune system process (GO:0002682) 2.52CREBBP, EP300
regulation of defense response (GO:0031347) 3.112CREBBP, EP300
histone acetylation (GO:0016573) 5.092CREBBP, EP300
cellular response to abiotic stimulus (GO:0071214) 4.152CREBBP, EP300
heterocycle biosynthetic process (GO:0018130) 1.72CREBBP, EP300
internal peptidyl-lysine acetylation (GO:0018393) 5.052CREBBP, EP300
response to cytokine (GO:0034097) 3.842CREBBP, EP300
peptidyl-lysine acetylation (GO:0018394) 5.032CREBBP, EP300
regulation of biosynthetic process (GO:0009889) 1.372CREBBP, EP300
regulation of cellular process (GO:0050794) 0.52CREBBP, EP300
regulation of cell cycle phase transition (GO:1901987) 4.152CREBBP, EP300
macromolecule modification (GO:0043412) 1.732CREBBP, EP300
protein modification process (GO:0036211) 1.792CREBBP, EP300
regulation of multicellular organismal process (GO:0051239) 1.872CREBBP, EP300
nucleobase-containing compound biosynthetic process (GO:0034654) 1.722CREBBP, EP300
regulation of intracellular signal transduction (GO:1902531) 2.312CREBBP, EP300
positive regulation of macromolecule metabolic process (GO:0010604) 1.812CREBBP, EP300
RNA metabolic process (GO:0016070) 1.592CREBBP, EP300
negative regulation of RNA biosynthetic process (GO:1902679) 2.72CREBBP, EP300
immune response-activating signal transduction (GO:0002757) 3.82CREBBP, EP300
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592CREBBP, EP300
response to decreased oxygen levels (GO:0036293) 4.092CREBBP, EP300
response to stimulus (GO:0050896) 1.222CREBBP, EP300
regulation of cellular response to stress (GO:0080135) 3.42CREBBP, EP300
innate immune response-activating signal transduction (GO:0002758) 4.452CREBBP, EP300
response to stress (GO:0006950) 1.82CREBBP, EP300
regulation of transcription, DNA-templated (GO:0006355) 1.562CREBBP, EP300
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392CREBBP, EP300
regulation of macromolecule biosynthetic process (GO:0010556) 1.432CREBBP, EP300
transcription, DNA-templated (GO:0006351) 1.912CREBBP, EP300
positive regulation of type I interferon production (GO:0032481) 5.482CREBBP, EP300
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532CREBBP, EP300
cellular response to light stimulus (GO:0071482) 5.222CREBBP, EP300
RNA biosynthetic process (GO:0032774) 1.842CREBBP, EP300
response to radiation (GO:0009314) 3.692CREBBP, EP300
cellular biosynthetic process (GO:0044249) 1.372CREBBP, EP300
cellular nitrogen compound metabolic process (GO:0034641) 1.222CREBBP, EP300
response to UV (GO:0009411) 4.882CREBBP, EP300
response to light stimulus (GO:0009416) 4.082CREBBP, EP300
regulation of mitotic cell cycle phase transition (GO:1901990) 4.232CREBBP, EP300
cellular macromolecule biosynthetic process (GO:0034645) 1.662CREBBP, EP300
regulation of signaling (GO:0023051) 1.722CREBBP, EP300
anatomical structure morphogenesis (GO:0009653) 2.532CREBBP, EP300
single-organism process (GO:0044699) 0.482CREBBP, EP300
nucleobase-containing compound metabolic process (GO:0006139) 1.352CREBBP, EP300
cellular response to radiation (GO:0071478) 4.812CREBBP, EP300
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122CREBBP, EP300
positive regulation of multicellular organismal process (GO:0051240) 2.492CREBBP, EP300
regulation of cell cycle process (GO:0010564) 3.52CREBBP, EP300
regulation of transcription from RNA polymerase II promoter in response to stress (GO:0043618) 5.62CREBBP, EP300
negative regulation of cellular biosynthetic process (GO:0031327) 2.492CREBBP, EP300
response to oxygen levels (GO:0070482) 4.022CREBBP, EP300
innate immune response activating cell surface receptor signaling pathway (GO:0002220) 5.072CREBBP, EP300
stimulatory C-type lectin receptor signaling pathway (GO:0002223) 5.092CREBBP, EP300
developmental process (GO:0032502) 1.362CREBBP, EP300
response to abiotic stimulus (GO:0009628) 2.82CREBBP, EP300
positive regulation of cell cycle process (GO:0090068) 4.252CREBBP, EP300
cellular process (GO:0009987) 0.262CREBBP, EP300
cellular aromatic compound metabolic process (GO:0006725) 1.32CREBBP, EP300
regulation of nucleic acid-templated transcription (GO:1903506) 1.552CREBBP, EP300
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712CREBBP, EP300
negative regulation of transcription, DNA-templated (GO:0045892) 2.752CREBBP, EP300
positive regulation of transcription, DNA-templated (GO:0045893) 2.562CREBBP, EP300
regulation of G1/S transition of mitotic cell cycle (GO:2000045) 4.812CREBBP, EP300
nucleic acid metabolic process (GO:0090304) 1.462CREBBP, EP300
regulation of immune response (GO:0050776) 2.982CREBBP, EP300
regulation of biological quality (GO:0065008) 1.682CREBBP, EP300
regulation of cellular response to heat (GO:1900034) 5.412CREBBP, EP300
negative regulation of RNA metabolic process (GO:0051253) 2.662CREBBP, EP300
regulation of RNA metabolic process (GO:0051252) 1.522CREBBP, EP300
positive regulation of immune response (GO:0050778) 3.42CREBBP, EP300
macromolecule biosynthetic process (GO:0009059) 1.612CREBBP, EP300
macromolecule metabolic process (GO:0043170) 0.832CREBBP, EP300
positive regulation of RNA biosynthetic process (GO:1902680) 2.542CREBBP, EP300
regulation of cytokine production (GO:0001817) 3.42CREBBP, EP300
positive regulation of gene expression (GO:0010628) 2.352CREBBP, EP300
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.812CREBBP, EP300
regulation of type I interferon production (GO:0032479) 5.032CREBBP, EP300
regulation of response to stress (GO:0080134) 2.532CREBBP, EP300
positive regulation of cytokine production (GO:0001819) 3.822CREBBP, EP300
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562CREBBP, EP300
positive regulation of cellular biosynthetic process (GO:0031328) 2.32CREBBP, EP300
macromolecular complex subunit organization (GO:0043933) 2.142CREBBP, EP300
regulation of cellular biosynthetic process (GO:0031326) 1.382CREBBP, EP300
positive regulation of cellular metabolic process (GO:0031325) 1.812CREBBP, EP300
negative regulation of cellular metabolic process (GO:0031324) 2.012CREBBP, EP300
regulation of cellular metabolic process (GO:0031323) 1.072CREBBP, EP300
homeostatic process (GO:0042592) 2.612CREBBP, EP300
regulation of cell death (GO:0010941) 2.432CREBBP, EP300
protein complex subunit organization (GO:0071822) 2.62CREBBP, EP300
activation of innate immune response (GO:0002218) 4.412CREBBP, EP300
chromatin organization (GO:0006325) 3.282CREBBP, EP300
regulation of apoptotic process (GO:0042981) 2.52CREBBP, EP300
organic cyclic compound metabolic process (GO:1901360) 1.262CREBBP, EP300
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462CREBBP, EP300
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62CREBBP, EP300
organic substance metabolic process (GO:0071704) 0.632CREBBP, EP300
regulation of programmed cell death (GO:0043067) 2.492CREBBP, EP300
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242CREBBP, EP300
nucleic acid-templated transcription (GO:0097659) 1.912CREBBP, EP300
regulation of gene expression (GO:0010468) 1.372CREBBP, EP300
positive regulation of innate immune response (GO:0045089) 4.222CREBBP, EP300
regulation of innate immune response (GO:0045088) 3.862CREBBP, EP300
protein acylation (GO:0043543) 4.652CREBBP, EP300
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432CREBBP, EP300
N-terminal peptidyl-lysine acetylation (GO:0018076) 8.632CREBBP, EP300
protein complex assembly (GO:0006461) 2.782CREBBP, EP300
cellular protein modification process (GO:0006464) 1.792CREBBP, EP300
single-organism developmental process (GO:0044767) 1.492CREBBP, EP300
biosynthetic process (GO:0009058) 1.322CREBBP, EP300
multi-organism cellular process (GO:0044764) 3.142CREBBP, EP300
single-organism cellular process (GO:0044763) 0.652CREBBP, EP300
regulation of nitrogen compound metabolic process (GO:0051171) 1.362CREBBP, EP300
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472CREBBP, EP300
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292CREBBP, EP300
response to chemical (GO:0042221) 1.982CREBBP, EP300
regulation of DNA-templated transcription in response to stress (GO:0043620) 5.522CREBBP, EP300
primary metabolic process (GO:0044238) 0.692CREBBP, EP300
regulation of cell cycle (GO:0051726) 2.932CREBBP, EP300
biological regulation (GO:0065007) 0.392CREBBP, EP300
activation of immune response (GO:0002253) 3.672CREBBP, EP300
cellular metabolic process (GO:0044237) 0.692CREBBP, EP300
regulation of cell cycle G1/S phase transition (GO:1902806) 4.742CREBBP, EP300
viral process (GO:0016032) 3.152CREBBP, EP300
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.152CREBBP, EP300
negative regulation of cellular process (GO:0048523) 1.412CREBBP, EP300
positive regulation of cellular process (GO:0048522) 1.32CREBBP, EP300

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of histone acetylation (GO:0035065) NEW5.740.044CREBBP, EP300
V(D)J recombination (GO:0033151) NEW6.90.003CREBBP, EP300
bile acid and bile salt transport (GO:0015721) NEW6.360.013CREBBP, EP300
protein acetylation (GO:0006473) -4.860.011CREBBP, EP300
internal protein amino acid acetylation (GO:0006475) -4.990.009CREBBP, EP300
N-terminal protein amino acid acetylation (GO:0006474) -7.020.001CREBBP, EP300
labyrinthine layer blood vessel development (GO:0060716) NEW6.840.015CREBBP, EP300
cartilage condensation (GO:0001502) NEW6.640.013CREBBP, EP300
regulation of histone H3-K4 methylation (GO:0051569) NEW6.360.01CREBBP, EP300
eyelid development in camera-type eye (GO:0061029) NEW7.160.004CREBBP, EP300
Notch signaling pathway (GO:0007219) -4.990.013CREBBP, EP300
stem cell development (GO:0048864) NEW7.940.017CREBBP, EP300
renal water transport (GO:0003097) NEW8.120.001CREBBP, EP300
rhythmic process (GO:0048511) -4.020.043CREBBP, EP300
regulation of stem cell maintenance (GO:2000036) NEW6.90.005CREBBP, EP300
histone H3 acetylation (GO:0043966) NEW5.920.046CREBBP, EP300
histone H4 acetylation (GO:0043967) NEW5.820.042CREBBP, EP300
pigment cell differentiation (GO:0050931) NEW6.640.01CREBBP, EP300
spinal cord development (GO:0021510) NEW6.090.008CREBBP, EP300
response to vitamin A (GO:0033189) NEW6.640.011CREBBP, EP300
noradrenergic neuron differentiation (GO:0003357) NEW8.120.0CREBBP, EP300
interaction with symbiont (GO:0051702) NEW5.760.032CREBBP, EP300
positive regulation of BMP signaling pathway (GO:0030513) NEW6.260.019CREBBP, EP300
cardiac ventricle formation (GO:0003211) NEW7.430.002CREBBP, EP300
peptidyl-lysine modification (GO:0018205) -3.980.018CREBBP, EP300
ventricular septum morphogenesis (GO:0060412) NEW6.590.012CREBBP, EP300
somatic cell DNA recombination (GO:0016444) NEW6.230.021CREBBP, EP300
glial cell development (GO:0021782) NEW5.780.048CREBBP, EP300
heart valve morphogenesis (GO:0003179) NEW6.550.023CREBBP, EP300
sympathetic nervous system development (GO:0048485) NEW6.960.007CREBBP, EP300
N-terminal protein amino acid modification (GO:0031365) -6.470.003CREBBP, EP300
placenta blood vessel development (GO:0060674) NEW6.40.045CREBBP, EP300
regulation of transcription from RNA polymerase II promoter in response to hypoxia (GO:0061418) -6.260.001CREBBP, EP300
intrinsic apoptotic signaling pathway by p53 class mediator (GO:0072332) NEW5.760.035CREBBP, EP300
negative regulation of gliogenesis (GO:0014014) NEW6.090.05CREBBP, EP300
protein acylation (GO:0043543) -4.650.018CREBBP, EP300
cardiac chamber formation (GO:0003207) NEW7.330.003CREBBP, EP300
regulation of erythrocyte differentiation (GO:0045646) NEW6.150.028CREBBP, EP300
cellular response to interleukin-4 (GO:0071353) NEW6.640.009CREBBP, EP300
cellular response to oxygen levels (GO:0071453) NEW4.970.008CREBBP, EP300
histone acetylation (GO:0016573) -5.090.008CREBBP, EP300
cellular response to hypoxia (GO:0071456) NEW5.110.007CREBBP, EP300
somatic diversification of immune receptors (GO:0002200) NEW5.920.026CREBBP, EP300
thyroid gland development (GO:0030878) NEW6.470.016CREBBP, EP300
internal peptidyl-lysine acetylation (GO:0018393) -5.050.008CREBBP, EP300
embryonic digestive tract morphogenesis (GO:0048557) NEW6.90.012CREBBP, EP300
T cell differentiation in thymus (GO:0033077) NEW6.330.032CREBBP, EP300
peptidyl-lysine acetylation (GO:0018394) -5.030.009CREBBP, EP300
peripheral nervous system neuron development (GO:0048935) NEW7.330.002CREBBP, EP300
positive regulation of type I interferon production (GO:0032481) -5.480.004CREBBP, EP300
positive regulation of protein acetylation (GO:1901985) NEW6.150.015CREBBP, EP300
oligodendrocyte development (GO:0014003) NEW6.510.008CREBBP, EP300
mesenchymal cell development (GO:0014031) NEW6.550.01CREBBP, EP300
modulation of transcription in other organism involved in symbiotic interaction (GO:0052312) NEW6.640.012CREBBP, EP300
response to decreased oxygen levels (GO:0036293) -4.090.043CREBBP, EP300
cellular response to decreased oxygen levels (GO:0036294) NEW5.050.007CREBBP, EP300
renal water absorption (GO:0070295) NEW8.630.0CREBBP, EP300
positive regulation of DNA repair (GO:0045739) NEW6.090.015CREBBP, EP300
endocrine pancreas development (GO:0031018) NEW6.360.047CREBBP, EP300
negative regulation of T cell differentiation (GO:0045581) NEW6.260.023CREBBP, EP300
regulation of transcription from RNA polymerase II promoter in response to stress (GO:0043618) -5.60.001CREBBP, EP300
positive regulation of viral transcription (GO:0050434) NEW6.070.028CREBBP, EP300
response to hypoxia (GO:0001666) -4.130.042CREBBP, EP300
modification by host of symbiont morphology or physiology (GO:0051851) NEW5.80.029CREBBP, EP300
neuroepithelial cell differentiation (GO:0060563) NEW6.510.04CREBBP, EP300
negative regulation of lymphocyte differentiation (GO:0045620) NEW6.040.046CREBBP, EP300
regulation of DNA-templated transcription in response to stress (GO:0043620) -5.520.044CREBBP, EP300
melanocyte differentiation (GO:0030318) NEW6.730.009CREBBP, EP300
somatic diversification of immune receptors via germline recombination within a single locus (GO:0002562) NEW6.230.021CREBBP, EP300
N-terminal peptidyl-lysine acetylation (GO:0018076) -8.630.0CREBBP, EP300
nephron epithelium development (GO:0072009) NEW6.730.015CREBBP, EP300
modulation by host of viral transcription (GO:0043921) NEW6.680.009CREBBP, EP300
positive regulation by host of viral transcription (GO:0043923) NEW7.240.002CREBBP, EP300
somite development (GO:0061053) NEW7.020.003CREBBP, EP300
vascular smooth muscle cell differentiation (GO:0035886) NEW7.940.0CREBBP, EP300
regulation of transcription regulatory region DNA binding (GO:2000677) NEW6.120.01CREBBP, EP300
response to interleukin-4 (GO:0070670) NEW6.40.015CREBBP, EP300
nephron tubule development (GO:0072080) NEW6.90.009CREBBP, EP300
regulation of type I interferon production (GO:0032479) -5.030.008CREBBP, EP300
renal tubule development (GO:0061326) NEW6.780.011CREBBP, EP300
soft palate development (GO:0060023) NEW8.120.001CREBBP, EP300
epithelial tube formation (GO:0072175) NEW6.360.015CREBBP, EP300
modulation by host of symbiont transcription (GO:0052472) NEW6.680.009CREBBP, EP300
lens development in camera-type eye (GO:0002088) NEW6.090.039CREBBP, EP300
pituitary gland development (GO:0021983) NEW6.330.021CREBBP, EP300
regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358) NEW7.240.003CREBBP, EP300
response to cadmium ion (GO:0046686) NEW6.020.036CREBBP, EP300
regulation of mesonephros development (GO:0061217) NEW6.470.016CREBBP, EP300
neuron fate commitment (GO:0048663) NEW6.120.045CREBBP, EP300
response to lithium ion (GO:0010226) NEW6.430.015CREBBP, EP300
response to oxygen levels (GO:0070482) -4.020.048CREBBP, EP300
embryonic epithelial tube formation (GO:0001838) NEW6.40.015CREBBP, EP300
nucleus organization (GO:0006997) NEW5.490.036CREBBP, EP300
positive regulation of peptidyl-lysine acetylation (GO:2000758) NEW6.290.015CREBBP, EP300
apoptotic process involved in development (GO:1902742) NEW6.680.015CREBBP, EP300
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
protein acetyltransferase complex (GO:0031248) 5.212CREBBP, EP300
intracellular organelle (GO:0043229) 0.512CREBBP, EP300
chromatin (GO:0000785) 3.992CREBBP, EP300
membrane-bounded organelle (GO:0043227) 0.472CREBBP, EP300
organelle (GO:0043226) 0.42CREBBP, EP300
cytoplasm (GO:0005737) 1.012CREBBP, EP300
histone acetyltransferase complex (GO:0000123) 5.322CREBBP, EP300
nucleus (GO:0005634) 1.072CREBBP, EP300
nucleoplasm (GO:0005654) 1.892CREBBP, EP300
nucleoplasm part (GO:0044451) 3.222CREBBP, EP300
acetyltransferase complex (GO:1902493) 5.212CREBBP, EP300
catalytic complex (GO:1902494) 2.92CREBBP, EP300
transferase complex (GO:1990234) 3.322CREBBP, EP300
protein complex (GO:0043234) 1.512CREBBP, EP300
macromolecular complex (GO:0032991) 1.352CREBBP, EP300
intracellular membrane-bounded organelle (GO:0043231) 0.62CREBBP, EP300
cell part (GO:0044464) 0.112CREBBP, EP300
intracellular organelle part (GO:0044446) 0.812CREBBP, EP300
nuclear part (GO:0044428) 1.552CREBBP, EP300
transcription factor complex (GO:0005667) 4.12CREBBP, EP300
intracellular part (GO:0044424) 0.282CREBBP, EP300
chromosomal part (GO:0044427) 3.182CREBBP, EP300
organelle part (GO:0044422) 0.792CREBBP, EP300

NET-GE enrichment

Term New enriched termICP valueGenes
protein acetyltransferase complex (GO:0031248) -5.210.001CREBBP, EP300
apical part of cell (GO:0045177) NEW5.340.029CREBBP, EP300
intercellular bridge (GO:0045171) NEW6.020.002CREBBP, EP300
protein-DNA complex (GO:0032993) NEW5.030.05CREBBP, EP300
histone acetyltransferase complex (GO:0000123) -5.320.005CREBBP, EP300
PML body (GO:0016605) NEW5.240.019CREBBP, EP300
transferase complex (GO:1990234) -3.320.02CREBBP, EP300
acetyltransferase complex (GO:1902493) -5.210.001CREBBP, EP300
catalytic complex (GO:1902494) -2.90.047CREBBP, EP300
transport vesicle membrane (GO:0030658) NEW4.860.025CREBBP, EP300
nuclear transcription factor complex (GO:0044798) NEW4.950.007CREBBP, EP300
nucleoplasm part (GO:0044451) -3.220.031CREBBP, EP300
transcription factor complex (GO:0005667) -4.10.006CREBBP, EP300
perikaryon (GO:0043204) NEW5.130.021CREBBP, EP300
chromosome, centromeric region (GO:0000775) NEW4.850.006CREBBP, EP300
kinetochore (GO:0000776) NEW5.050.011CREBBP, EP300
condensed chromosome kinetochore (GO:0000777) NEW5.310.006CREBBP, EP300