Disease table of IMMUNODEFICIENCY WITH HYPER-IGM OMIM ID: PS308230

Gene-disease associations table

Gene	Associated with IMMUNODEFICIENCY WITH HYPER-IGM in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
UNG	ClinVar, OMIM, HUMSAVAR	HGNC link	12q24.11	1	PS308230
CD40LG	ClinVar, OMIM, HUMSAVAR	HGNC link	Xq26.3	1	PS308230
AICDA	ClinVar, OMIM, HUMSAVAR	HGNC link	12p13.31	1	PS308230
CD40	ClinVar, OMIM, HUMSAVAR	HGNC link	20q13.12	1	PS308230

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
12	2	AICDA, UNG

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
STAT1	NO	79	CFTR, IFNG, NOS2, MET, TP53, CTSB, STRA13, TNFSF13B, S100A10, FCGR1A, FGF2, NOX1, EGFR, IL1B, GAST, ICAM1, TBX21, MVP, PTGS2, FGFR3, OPRM1, STAT2, XAF1, IRF8, HMOX1, FAS, UPP1, CXCL9, IRF7, PIM1, SOCS1, EDN1, KRT17, TLR3, IRF1, IL27, CEBPD, CTSL, CCL2, CDKN1A, IFNB1, CXCL10, CEBPE, PSMB9, FOXP3, IFNA1, NR1H4, FCGRT, TAP1, EGR1, HSP90AA1, PDCD1, JAK2, IVL, IL2RA, CD40, CCL3, CCR1, GLS, STAT3, MMP9, BAX, CD40LG, CD86, IL1R1, SCARB1, NOX4, NOX5, ACAT1, IL6, MUC4, MMP13, LY96, IFIT3, CD22, CIITA, IFNLR1, PPARG, PML	2	CD40, CD40LG
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	2	CD40, CD40LG
RELA	NO	302	NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC6	2	CD40, CD40LG

regulated gene	associated to this disease	# TFs	TFs
CD40LG	YES	7	GATA3, FOS, RELA, JUND, NFKB1, REL, STAT1
AICDA	YES	1	TCF3
CD40	YES	14	XRCC5, RELA, SPI1, NR3C2, NFKB1, IRF1, XRCC6, NFKBIA, MCM6, SPIB, RELB, STAT6, TRERF1, STAT1

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
UNG	AICDA	No	3	RPA1, APP, PCNA
CD40LG	CD40	Yes	4	BIRC2, CD40, TRAF1, TRAF2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
CD40LG	CD40	Yes	2	CD40, CD40LG

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Primary immunodeficiency	hsa05340	7.52	4	AICDA, UNG, CD40, CD40LG
Intestinal immune network for IgA production	hsa04672	6.79	3	AICDA, CD40, CD40LG
Systemic lupus erythematosus	hsa05322	5.95	2	CD40, CD40LG
Autoimmune thyroid disease	hsa05320	6.62	2	CD40, CD40LG
Toxoplasmosis	hsa05145	5.71	2	CD40, CD40LG
Allograft rejection	hsa05330	6.91	2	CD40, CD40LG
Cell adhesion molecules (CAMs)	hsa04514	5.36	2	CD40, CD40LG
Viral myocarditis	hsa05416	6.45	2	CD40, CD40LG
Malaria	hsa05144	7.15	2	CD40, CD40LG
Asthma	hsa05310	7.34	2	CD40, CD40LG
NF-kappa B signaling pathway	hsa04064	6.21	2	CD40, CD40LG
Cytokine-cytokine receptor interaction	hsa04060	4.67	2	CD40, CD40LG

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Immune diseases	NEW	4.47	0.0	AICDA, UNG, CD40, CD40LG
Systemic lupus erythematosus (hsa05322)	-	5.95	0.049	CD40, CD40LG
Autoimmune thyroid disease (hsa05320)	-	6.62	0.019	CD40, CD40LG
Allograft rejection (hsa05330)	-	6.91	0.013	CD40, CD40LG
Intestinal immune network for IgA production (hsa04672)	-	6.79	0.0	AICDA, CD40, CD40LG
Malaria (hsa05144)	-	7.15	0.009	CD40, CD40LG
Asthma (hsa05310)	-	7.34	0.026	CD40, CD40LG
Primary immunodeficiency (hsa05340)	-	7.52	0.0	AICDA, UNG, CD40, CD40LG
NF-kappa B signaling pathway (hsa04064)	-	6.21	0.034	CD40, CD40LG
Viral myocarditis (hsa05416)	-	6.45	0.025	CD40, CD40LG

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
TNFR2 non-canonical NF-kB pathway	R-HSA-5668541	6.4	2	CD40, CD40LG
Immune System	R-HSA-168256	2.37	2	CD40, CD40LG
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	2	CD40, CD40LG
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	R-HSA-5676594	8.89	2	CD40, CD40LG
Adaptive Immune System	R-HSA-1280218	3.19	2	CD40, CD40LG
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	R-HSA-198933	4.7	2	CD40, CD40LG

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
TNFR2 non-canonical NF-kB pathway (R-HSA-5668541)	-	6.4	0.006	AICDA, CD40, CD40LG
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (R-HSA-5676594)	-	8.89	0.0	CD40, CD40LG
TNFs bind their physiological receptors (R-HSA-5669034)	NEW	8.34	0.008	CD40, CD40LG

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	4	AICDA, UNG, CD40, CD40LG
protein binding (GO:0005515)	0.46	4	AICDA, UNG, CD40, CD40LG
enzyme binding (GO:0019899)	2.27	3	AICDA, UNG, CD40
hydrolase activity (GO:0016787)	1.9	2	AICDA, UNG
ubiquitin protein ligase binding (GO:0031625)	4.17	2	AICDA, CD40
ubiquitin-like protein ligase binding (GO:0044389)	4.15	2	AICDA, CD40
catalytic activity (GO:0003824)	1.05	2	AICDA, UNG

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
tumor necrosis factor receptor superfamily binding (GO:0032813)	NEW	5.89	0.016	CD40, CD40LG
small conjugating protein ligase binding (GO:0044389)	-	4.15	0.019	AICDA, CD40
tumor necrosis factor receptor binding (GO:0005164)	NEW	6.3	0.007	CD40, CD40LG
ubiquitin protein ligase binding (GO:0031625)	-	4.17	0.019	AICDA, CD40

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
positive regulation of metabolic process (GO:0009893)	1.74	4	AICDA, UNG, CD40, CD40LG
regulation of metabolic process (GO:0019222)	1.02	4	AICDA, UNG, CD40, CD40LG
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	4	AICDA, UNG, CD40, CD40LG
regulation of cellular metabolic process (GO:0031323)	1.07	4	UNG, AICDA, CD40, CD40LG
response to stimulus (GO:0050896)	1.22	4	AICDA, UNG, CD40, CD40LG
cellular process (GO:0009987)	0.26	4	AICDA, UNG, CD40, CD40LG
regulation of primary metabolic process (GO:0080090)	1.08	4	AICDA, UNG, CD40, CD40LG
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	4	AICDA, UNG, CD40, CD40LG
positive regulation of cellular metabolic process (GO:0031325)	1.81	4	AICDA, UNG, CD40, CD40LG
regulation of cellular process (GO:0050794)	0.5	4	UNG, AICDA, CD40, CD40LG
immune system process (GO:0002376)	2.29	4	AICDA, UNG, CD40, CD40LG
regulation of macromolecule metabolic process (GO:0060255)	1.08	4	AICDA, UNG, CD40, CD40LG
single-organism cellular process (GO:0044763)	0.65	4	AICDA, UNG, CD40, CD40LG
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	4	AICDA, UNG, CD40, CD40LG
positive regulation of biological process (GO:0048518)	1.2	4	UNG, AICDA, CD40, CD40LG
biological regulation (GO:0065007)	0.39	4	AICDA, UNG, CD40, CD40LG
regulation of biological process (GO:0050789)	0.45	4	AICDA, UNG, CD40, CD40LG
single-organism process (GO:0044699)	0.48	4	AICDA, UNG, CD40, CD40LG
positive regulation of cellular process (GO:0048522)	1.3	4	AICDA, UNG, CD40, CD40LG
metabolic process (GO:0008152)	0.58	3	AICDA, UNG, CD40LG
regulation of cell activation (GO:0050865)	3.53	3	UNG, CD40, CD40LG
regulation of cellular biosynthetic process (GO:0031326)	1.38	3	AICDA, CD40, CD40LG
positive regulation of cell activation (GO:0050867)	3.97	3	UNG, CD40, CD40LG
positive regulation of response to stimulus (GO:0048584)	2.18	3	UNG, CD40, CD40LG
regulation of response to stimulus (GO:0048583)	1.54	3	UNG, CD40, CD40LG
B cell activation (GO:0042113)	4.84	3	AICDA, CD40, CD40LG
nucleic acid metabolic process (GO:0090304)	1.46	3	AICDA, UNG, CD40LG
leukocyte activation (GO:0045321)	3.76	3	AICDA, CD40, CD40LG
cellular nitrogen compound metabolic process (GO:0034641)	1.22	3	AICDA, UNG, CD40LG
nitrogen compound metabolic process (GO:0006807)	1.13	3	AICDA, UNG, CD40LG
regulation of production of molecular mediator of immune response (GO:0002700)	5.1	3	UNG, CD40, CD40LG
regulation of cell death (GO:0010941)	2.43	3	UNG, CD40, CD40LG
regulation of apoptotic process (GO:0042981)	2.5	3	UNG, CD40, CD40LG
organic cyclic compound metabolic process (GO:1901360)	1.26	3	AICDA, UNG, CD40LG
nucleobase-containing compound metabolic process (GO:0006139)	1.35	3	AICDA, UNG, CD40LG
cellular response to stimulus (GO:0051716)	1.97	3	UNG, AICDA, CD40
regulation of lymphocyte activation (GO:0051249)	3.73	3	UNG, CD40, CD40LG
cellular macromolecule metabolic process (GO:0044260)	0.93	3	AICDA, UNG, CD40LG
regulation of transcription, DNA-templated (GO:0006355)	1.56	3	AICDA, CD40, CD40LG
positive regulation of multicellular organismal process (GO:0051240)	2.49	3	UNG, CD40, CD40LG
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	3	AICDA, CD40, CD40LG
positive regulation of immune system process (GO:0002684)	2.96	3	UNG, CD40, CD40LG
organic substance metabolic process (GO:0071704)	0.63	3	AICDA, UNG, CD40LG
regulation of programmed cell death (GO:0043067)	2.49	3	UNG, CD40, CD40LG
positive regulation of leukocyte activation (GO:0002696)	4.0	3	UNG, CD40, CD40LG
regulation of immune system process (GO:0002682)	2.5	3	UNG, CD40, CD40LG
negative regulation of biological process (GO:0048519)	1.33	3	AICDA, UNG, CD40LG
somatic diversification of immune receptors (GO:0002200)	5.92	3	AICDA, UNG, CD40LG
regulation of gene expression (GO:0010468)	1.37	3	AICDA, CD40, CD40LG
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	3	AICDA, UNG, CD40
regulation of DNA metabolic process (GO:0051052)	3.87	3	AICDA, UNG, CD40
primary metabolic process (GO:0044238)	0.69	3	AICDA, UNG, CD40LG
cellular aromatic compound metabolic process (GO:0006725)	1.3	3	AICDA, UNG, CD40LG
regulation of biosynthetic process (GO:0009889)	1.37	3	AICDA, CD40, CD40LG
single-organism metabolic process (GO:0044710)	1.63	3	AICDA, UNG, CD40LG
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	3	AICDA, CD40, CD40LG
regulation of immunoglobulin production (GO:0002637)	5.86	3	UNG, CD40, CD40LG
response to stress (GO:0006950)	1.8	3	UNG, CD40, CD40LG
lymphocyte activation (GO:0046649)	3.96	3	AICDA, CD40, CD40LG
regulation of multicellular organismal process (GO:0051239)	1.87	3	UNG, CD40, CD40LG
regulation of RNA biosynthetic process (GO:2001141)	1.55	3	AICDA, CD40, CD40LG
heterocycle metabolic process (GO:0046483)	1.31	3	AICDA, UNG, CD40LG
DNA recombination (GO:0006310)	4.39	3	AICDA, UNG, CD40LG
somatic diversification of immune receptors via germline recombination within a single locus (GO:0002562)	6.23	3	AICDA, UNG, CD40LG
regulation of immune response (GO:0050776)	2.98	3	UNG, CD40, CD40LG
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	3	AICDA, UNG, CD40
positive regulation of lymphocyte activation (GO:0051251)	4.07	3	UNG, CD40, CD40LG
regulation of RNA metabolic process (GO:0051252)	1.52	3	AICDA, CD40, CD40LG
cell activation (GO:0001775)	3.47	3	AICDA, CD40, CD40LG
cellular metabolic process (GO:0044237)	0.69	3	AICDA, UNG, CD40LG
macromolecule metabolic process (GO:0043170)	0.83	3	AICDA, UNG, CD40LG
regulation of leukocyte activation (GO:0002694)	3.6	3	UNG, CD40, CD40LG
regulation of immune effector process (GO:0002697)	3.71	3	UNG, CD40, CD40LG
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	3	AICDA, CD40, CD40LG
negative regulation of cellular process (GO:0048523)	1.41	3	AICDA, UNG, CD40LG
immune effector process (GO:0002252)	3.58	3	AICDA, CD40, CD40LG
DNA metabolic process (GO:0006259)	3.09	3	AICDA, UNG, CD40LG
somatic diversification of immunoglobulins (GO:0016445)	6.26	3	AICDA, UNG, CD40LG
somatic cell DNA recombination (GO:0016444)	6.23	3	AICDA, UNG, CD40LG
somatic recombination of immunoglobulin gene segments (GO:0016447)	6.68	3	AICDA, UNG, CD40LG
regulation of phosphate metabolic process (GO:0019220)	2.35	2	CD40, CD40LG
cytokine-mediated signaling pathway (GO:0019221)	3.6	2	CD40, CD40LG
regulation of secretion (GO:0051046)	3.2	2	CD40, CD40LG
regulation of transport (GO:0051049)	2.24	2	CD40, CD40LG
regulation of lymphocyte mediated immunity (GO:0002706)	4.99	2	UNG, CD40
positive regulation of leukocyte mediated immunity (GO:0002705)	5.32	2	UNG, CD40
regulation of leukocyte mediated immunity (GO:0002703)	4.7	2	UNG, CD40
signal transduction (GO:0007165)	1.28	2	CD40, CD40LG
cell surface receptor signaling pathway (GO:0007166)	2.09	2	CD40, CD40LG
positive regulation of lymphocyte mediated immunity (GO:0002708)	5.49	2	UNG, CD40
single-organism catabolic process (GO:0044712)	3.21	2	AICDA, UNG
leukocyte proliferation (GO:0070661)	5.25	2	CD40, CD40LG
DNA modification (GO:0006304)	5.36	2	AICDA, UNG
response to external biotic stimulus (GO:0043207)	3.13	2	AICDA, CD40
regulation of signal transduction (GO:0009966)	1.84	2	CD40, CD40LG
cellular developmental process (GO:0048869)	1.82	2	AICDA, CD40LG
cell activation involved in immune response (GO:0002263)	4.86	2	AICDA, CD40LG
cellular response to organic substance (GO:0071310)	2.78	2	AICDA, CD40
interspecies interaction between organisms (GO:0044419)	3.08	2	UNG, CD40
leukocyte activation involved in immune response (GO:0002366)	4.88	2	AICDA, CD40LG
nucleobase-containing small molecule metabolic process (GO:0055086)	3.59	2	AICDA, UNG
positive regulation of molecular function (GO:0044093)	2.23	2	CD40, CD40LG
regulation of cell proliferation (GO:0042127)	2.41	2	CD40, CD40LG
positive regulation of DNA metabolic process (GO:0051054)	4.49	2	UNG, CD40
positive regulation of epithelial cell apoptotic process (GO:1904037)	6.55	2	CD40, CD40LG
negative regulation of cell death (GO:0060548)	2.95	2	UNG, CD40LG
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002824)	5.48	2	UNG, CD40
regulation of protein kinase activity (GO:0045859)	3.15	2	CD40, CD40LG
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002822)	4.99	2	UNG, CD40
positive regulation of adaptive immune response (GO:0002821)	5.42	2	UNG, CD40
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090)	3.83	2	CD40, CD40LG
organonitrogen compound metabolic process (GO:1901564)	2.32	2	AICDA, UNG
response to organic substance (GO:0010033)	2.2	2	AICDA, CD40
platelet activation (GO:0030168)	4.96	2	CD40, CD40LG
multi-organism process (GO:0051704)	2.65	2	UNG, CD40
regulation of phosphorylation (GO:0042325)	2.5	2	CD40, CD40LG
cellular catabolic process (GO:0044248)	2.62	2	AICDA, UNG
positive regulation of phosphorylation (GO:0042327)	2.9	2	CD40, CD40LG
response to biotic stimulus (GO:0009607)	3.09	2	AICDA, CD40
organonitrogen compound catabolic process (GO:1901565)	3.91	2	AICDA, UNG
response to external stimulus (GO:0009605)	2.55	2	AICDA, CD40
positive regulation of developmental process (GO:0051094)	2.77	2	UNG, CD40
regulation of DNA recombination (GO:0000018)	5.65	2	UNG, CD40
aromatic compound catabolic process (GO:0019439)	3.79	2	AICDA, UNG
positive regulation of production of molecular mediator of immune response (GO:0002702)	5.55	2	UNG, CD40
positive regulation of biosynthetic process (GO:0009891)	2.29	2	AICDA, CD40
regulation of isotype switching (GO:0045191)	6.55	2	UNG, CD40
isotype switching (GO:0045190)	6.96	2	AICDA, CD40LG
positive regulation of immune response (GO:0050778)	3.4	2	UNG, CD40
regulation of immunoglobulin secretion (GO:0051023)	6.9	2	CD40, CD40LG
positive regulation of gene expression (GO:0010628)	2.35	2	AICDA, CD40
positive regulation of mononuclear cell proliferation (GO:0032946)	4.84	2	CD40, CD40LG
regulation of mononuclear cell proliferation (GO:0032944)	4.45	2	CD40, CD40LG
lymphocyte proliferation (GO:0046651)	5.35	2	CD40, CD40LG
positive regulation of protein serine/threonine kinase activity (GO:0071902)	4.06	2	CD40, CD40LG
response to lipopolysaccharide (GO:0032496)	4.03	2	AICDA, CD40
regulation of protein serine/threonine kinase activity (GO:0071900)	3.58	2	CD40, CD40LG
organic substance catabolic process (GO:1901575)	2.45	2	AICDA, UNG
positive regulation of transferase activity (GO:0051347)	3.31	2	CD40, CD40LG
lymphocyte activation involved in immune response (GO:0002285)	5.22	2	AICDA, CD40LG
regulation of kinase activity (GO:0043549)	3.07	2	CD40, CD40LG
regulation of signaling (GO:0023051)	1.72	2	CD40, CD40LG
somatic diversification of immunoglobulins involved in immune response (GO:0002208)	6.96	2	AICDA, CD40LG
regulation of protein secretion (GO:0050708)	3.77	2	CD40, CD40LG
regulation of epithelial cell apoptotic process (GO:1904035)	5.63	2	CD40, CD40LG
positive regulation of catalytic activity (GO:0043085)	2.4	2	CD40, CD40LG
cellular response to molecule of bacterial origin (GO:0071219)	4.88	2	AICDA, CD40
positive regulation of RNA metabolic process (GO:0051254)	2.51	2	AICDA, CD40
cellular response to biotic stimulus (GO:0071216)	4.76	2	AICDA, CD40
positive regulation of DNA recombination (GO:0045911)	6.84	2	UNG, CD40
regulation of protein localization (GO:0032880)	2.88	2	CD40, CD40LG
small molecule metabolic process (GO:0044281)	2.38	2	AICDA, UNG
somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	6.96	2	AICDA, CD40LG
regulation of establishment of protein localization (GO:0070201)	3.02	2	CD40, CD40LG
regulation of developmental process (GO:0050793)	2.1	2	UNG, CD40
regulation of catalytic activity (GO:0050790)	1.97	2	CD40, CD40LG
heterocycle catabolic process (GO:0046700)	3.82	2	AICDA, UNG
positive regulation of MAPK cascade (GO:0043410)	3.57	2	CD40, CD40LG
regulation of immunoglobulin mediated immune response (GO:0002889)	6.04	2	UNG, CD40
macromolecule modification (GO:0043412)	1.73	2	AICDA, UNG
inflammatory response (GO:0006954)	3.64	2	CD40, CD40LG
immune response (GO:0006955)	2.86	2	CD40, CD40LG
nucleobase-containing compound catabolic process (GO:0034655)	3.9	2	AICDA, UNG
regulation of intracellular signal transduction (GO:1902531)	2.31	2	CD40, CD40LG
leukocyte differentiation (GO:0002521)	4.13	2	AICDA, CD40LG
defense response (GO:0006952)	2.78	2	CD40, CD40LG
cellular nitrogen compound catabolic process (GO:0044270)	3.8	2	AICDA, UNG
positive regulation of protein modification process (GO:0031401)	2.7	2	CD40, CD40LG
regulation of transferase activity (GO:0051338)	2.88	2	CD40, CD40LG
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	2	AICDA, CD40
positive regulation of signal transduction (GO:0009967)	2.5	2	CD40, CD40LG
somatic hypermutation of immunoglobulin genes (GO:0016446)	6.9	2	AICDA, UNG
positive regulation of immune effector process (GO:0002699)	4.69	2	UNG, CD40
tumor necrosis factor-mediated signaling pathway (GO:0033209)	4.96	2	CD40, CD40LG
regulation of adaptive immune response (GO:0002819)	4.91	2	UNG, CD40
positive regulation of signaling (GO:0023056)	2.41	2	CD40, CD40LG
positive regulation of MAP kinase activity (GO:0043406)	4.39	2	CD40, CD40LG
regulation of MAP kinase activity (GO:0043405)	3.95	2	CD40, CD40LG
regulation of secretion by cell (GO:1903530)	3.28	2	CD40, CD40LG
cellular response to chemical stimulus (GO:0070887)	2.57	2	AICDA, CD40
positive regulation of intracellular signal transduction (GO:1902533)	2.95	2	CD40, CD40LG
positive regulation of cell communication (GO:0010647)	2.41	2	CD40, CD40LG
regulation of cell communication (GO:0010646)	1.73	2	CD40, CD40LG
positive regulation of immunoglobulin mediated immune response (GO:0002891)	6.47	2	UNG, CD40
regulation of MAPK cascade (GO:0043408)	3.22	2	CD40, CD40LG
positive regulation of isotype switching (GO:0045830)	6.96	2	UNG, CD40
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	2	CD40, CD40LG
positive regulation of kinase activity (GO:0033674)	3.54	2	CD40, CD40LG
regulation of protein metabolic process (GO:0051246)	1.93	2	CD40, CD40LG
positive regulation of protein metabolic process (GO:0051247)	2.43	2	CD40, CD40LG
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	2	CD40, CD40LG
regulation of protein modification process (GO:0031399)	2.32	2	CD40, CD40LG
positive regulation of cell proliferation (GO:0008284)	3.01	2	CD40, CD40LG
cell proliferation (GO:0008283)	3.23	2	CD40, CD40LG
positive regulation of interleukin-12 production (GO:0032735)	6.23	2	CD40, CD40LG
cellular response to lipid (GO:0071396)	3.96	2	AICDA, CD40
regulation of endothelial cell apoptotic process (GO:2000351)	5.99	2	CD40, CD40LG
positive regulation of B cell activation (GO:0050871)	5.27	2	UNG, CD40
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	2	AICDA, CD40
regulation of localization (GO:0032879)	1.94	2	CD40, CD40LG
positive regulation of immunoglobulin production (GO:0002639)	6.26	2	UNG, CD40
positive regulation of NF-kappaB transcription factor activity (GO:0051092)	4.85	2	CD40, CD40LG
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091)	4.29	2	CD40, CD40LG
regulation of cellular protein metabolic process (GO:0032268)	1.99	2	CD40, CD40LG
mononuclear cell proliferation (GO:0032943)	5.32	2	CD40, CD40LG
carbohydrate derivative catabolic process (GO:1901136)	4.61	2	AICDA, UNG
carbohydrate derivative metabolic process (GO:1901135)	3.07	2	AICDA, UNG
regulation of lymphocyte proliferation (GO:0050670)	4.46	2	CD40, CD40LG
positive regulation of lymphocyte proliferation (GO:0050671)	4.85	2	CD40, CD40LG
regulation of molecular function (GO:0065009)	1.78	2	CD40, CD40LG
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	2	AICDA, CD40
regulation of cytokine production (GO:0001817)	3.4	2	CD40, CD40LG
response to molecule of bacterial origin (GO:0002237)	3.99	2	AICDA, CD40
lymphocyte differentiation (GO:0030098)	4.49	2	AICDA, CD40LG
positive regulation of protein kinase activity (GO:0045860)	3.61	2	CD40, CD40LG
positive regulation of cytokine production (GO:0001819)	3.82	2	CD40, CD40LG
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	2	AICDA, CD40
cellular response to lipopolysaccharide (GO:0071222)	4.94	2	AICDA, CD40
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	2	AICDA, CD40
regulation of B cell activation (GO:0050864)	4.92	2	UNG, CD40
pyrimidine-containing compound catabolic process (GO:0072529)	6.26	2	AICDA, UNG
regulation of interleukin-12 production (GO:0032655)	5.78	2	CD40, CD40LG
positive regulation of cell death (GO:0010942)	3.32	2	CD40, CD40LG
pyrimidine-containing compound metabolic process (GO:0072527)	5.36	2	AICDA, UNG
regulation of protein transport (GO:0051223)	3.12	2	CD40, CD40LG
response to lipid (GO:0033993)	3.11	2	AICDA, CD40
positive regulation of apoptotic process (GO:0043065)	3.38	2	CD40, CD40LG
regulation of leukocyte proliferation (GO:0070663)	4.4	2	CD40, CD40LG
negative regulation of apoptotic process (GO:0043066)	3.04	2	UNG, CD40LG
positive regulation of leukocyte proliferation (GO:0070665)	4.79	2	CD40, CD40LG
negative regulation of programmed cell death (GO:0043069)	3.02	2	UNG, CD40LG
positive regulation of programmed cell death (GO:0043068)	3.38	2	CD40, CD40LG
positive regulation of phosphate metabolic process (GO:0045937)	2.78	2	CD40, CD40LG
B cell differentiation (GO:0030183)	5.24	2	AICDA, CD40LG
organic cyclic compound catabolic process (GO:1901361)	3.73	2	AICDA, UNG
B cell proliferation (GO:0042100)	6.12	2	CD40, CD40LG
regulation of phosphorus metabolic process (GO:0051174)	2.35	2	CD40, CD40LG
regulation of B cell mediated immunity (GO:0002712)	6.02	2	UNG, CD40
multi-organism cellular process (GO:0044764)	3.14	2	UNG, CD40
positive regulation of B cell mediated immunity (GO:0002714)	6.47	2	UNG, CD40
response to chemical (GO:0042221)	1.98	2	AICDA, CD40
positive regulation of endothelial cell apoptotic process (GO:2000353)	7.02	2	CD40, CD40LG
catabolic process (GO:0009056)	2.38	2	AICDA, UNG
response to oxygen-containing compound (GO:1901700)	2.57	2	AICDA, CD40
cellular response to oxygen-containing compound (GO:1901701)	3.22	2	AICDA, CD40
somatic diversification of immune receptors via somatic mutation (GO:0002566)	6.84	2	AICDA, UNG
regulation of multicellular organismal development (GO:2000026)	2.31	2	UNG, CD40
viral process (GO:0016032)	3.15	2	UNG, CD40
cell differentiation (GO:0030154)	2.14	2	AICDA, CD40LG
symbiosis, encompassing mutualism through parasitism (GO:0044403)	3.15	2	UNG, CD40
regulation of protein phosphorylation (GO:0001932)	2.57	2	CD40, CD40LG
positive regulation of protein phosphorylation (GO:0001934)	2.95	2	CD40, CD40LG
B cell activation involved in immune response (GO:0002312)	6.17	2	AICDA, CD40LG

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
negative regulation of chromatin silencing (GO:0031936)	NEW	7.53	0.007	AICDA, CD40
regulation of chromatin silencing (GO:0031935)	NEW	6.68	0.015	AICDA, CD40
isotype switching (GO:0045190)	-	6.96	0.013	AICDA, CD40LG
B cell activation (GO:0042113)	-	4.84	0.0	AICDA, CD40, CD40LG
mononuclear cell proliferation (GO:0032943)	-	5.32	0.043	CD40, CD40LG
regulation of production of molecular mediator of immune response (GO:0002700)	-	5.1	0.039	CD40, CD40LG
lymphocyte proliferation (GO:0046651)	-	5.35	0.041	CD40, CD40LG
lymphocyte activation involved in immune response (GO:0002285)	-	5.22	0.006	AICDA, CD40, CD40LG
cell activation involved in immune response (GO:0002263)	-	4.86	0.021	AICDA, CD40, CD40LG
leukocyte proliferation (GO:0070661)	-	5.25	0.05	CD40, CD40LG
somatic diversification of immunoglobulins involved in immune response (GO:0002208)	-	6.96	0.013	AICDA, CD40LG
leukocyte activation involved in immune response (GO:0002366)	-	4.88	0.021	AICDA, CD40, CD40LG
somatic diversification of immune receptors (GO:0002200)	-	5.92	0.0	AICDA, UNG, CD40LG
positive regulation of gene expression, epigenetic (GO:0045815)	NEW	5.76	0.02	AICDA, CD40
somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	-	6.96	0.013	AICDA, CD40LG
regulation of interleukin-12 production (GO:0032655)	-	5.78	0.012	CD40, CD40LG
B cell differentiation (GO:0030183)	-	5.24	0.007	AICDA, CD40, CD40LG
positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)	NEW	6.43	0.047	CD40, CD40LG
B cell proliferation (GO:0042100)	-	6.12	0.008	CD40, CD40LG
regulation of endothelial cell apoptotic process (GO:2000351)	-	5.99	0.006	CD40, CD40LG
regulation of immunoglobulin production (GO:0002637)	-	5.86	0.009	CD40, CD40LG
cell activation (GO:0001775)	-	3.47	0.043	AICDA, CD40, CD40LG
lymphocyte activation (GO:0046649)	-	3.96	0.006	AICDA, CD40, CD40LG
regulation of immunoglobulin secretion (GO:0051023)	-	6.9	0.007	CD40, CD40LG
regulation of alpha-beta T cell proliferation (GO:0046640)	NEW	6.51	0.042	CD40, CD40LG
positive regulation of endothelial cell apoptotic process (GO:2000353)	-	7.02	0.001	CD40, CD40LG
negative regulation of gene silencing (GO:0060969)	NEW	6.78	0.012	AICDA, CD40
regulation of gene silencing (GO:0060968)	NEW	5.9	0.049	AICDA, CD40
DNA recombination (GO:0006310)	-	4.39	0.002	UNG, AICDA, CD40, CD40LG
somatic diversification of immune receptors via germline recombination within a single locus (GO:0002562)	-	6.23	0.0	AICDA, UNG, CD40LG
somatic diversification of immune receptors via somatic mutation (GO:0002566)	-	6.84	0.0	AICDA, UNG
leukocyte activation (GO:0045321)	-	3.76	0.011	AICDA, CD40, CD40LG
T cell differentiation (GO:0030217)	NEW	5.11	0.021	AICDA, CD40, CD40LG
immune system process (GO:0002376)	-	2.29	0.04	AICDA, UNG, CD40, CD40LG
B cell activation involved in immune response (GO:0002312)	-	6.17	0.006	AICDA, CD40, CD40LG
immune effector process (GO:0002252)	-	3.58	0.034	AICDA, CD40, CD40LG
positive regulation of interleukin-12 production (GO:0032735)	-	6.23	0.004	CD40, CD40LG
positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)	NEW	6.55	0.03	CD40, CD40LG
somatic diversification of immunoglobulins (GO:0016445)	-	6.26	0.0	AICDA, UNG, CD40LG
somatic cell DNA recombination (GO:0016444)	-	6.23	0.0	AICDA, UNG, CD40LG
somatic recombination of immunoglobulin gene segments (GO:0016447)	-	6.68	0.0	AICDA, UNG, CD40LG
somatic hypermutation of immunoglobulin genes (GO:0016446)	-	6.9	0.0	AICDA, UNG

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	4	UNG, AICDA, CD40, CD40LG
intracellular part (GO:0044424)	0.28	3	AICDA, UNG, CD40
intracellular organelle (GO:0043229)	0.51	3	AICDA, UNG, CD40
membrane-bounded organelle (GO:0043227)	0.47	3	AICDA, UNG, CD40
organelle (GO:0043226)	0.4	3	AICDA, UNG, CD40
intracellular membrane-bounded organelle (GO:0043231)	0.6	3	UNG, AICDA, CD40
cytoplasm (GO:0005737)	1.01	2	AICDA, CD40
external side of plasma membrane (GO:0009897)	4.46	2	CD40, CD40LG
macromolecular complex (GO:0032991)	1.35	2	AICDA, CD40
extracellular space (GO:0005615)	2.63	2	CD40, CD40LG
plasma membrane part (GO:0044459)	1.95	2	CD40, CD40LG
nucleus (GO:0005634)	1.07	2	AICDA, UNG
membrane (GO:0016020)	0.68	2	CD40, CD40LG
extracellular region part (GO:0044421)	1.57	2	CD40, CD40LG
membrane part (GO:0044425)	0.95	2	CD40, CD40LG
cell surface (GO:0009986)	3.44	2	CD40, CD40LG
extracellular region (GO:0005576)	2.18	2	CD40, CD40LG
integral component of plasma membrane (GO:0005887)	2.57	2	CD40, CD40LG
side of membrane (GO:0098552)	4.22	2	CD40, CD40LG
protein complex (GO:0043234)	1.51	2	AICDA, CD40
plasma membrane (GO:0005886)	1.39	2	CD40, CD40LG
intrinsic component of plasma membrane (GO:0031226)	2.53	2	CD40, CD40LG
integral component of membrane (GO:0016021)	1.14	2	CD40, CD40LG
intrinsic component of membrane (GO:0031224)	1.13	2	CD40, CD40LG

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
external side of plasma membrane (GO:0009897)	-	4.46	0.019	CD40, CD40LG
side of membrane (GO:0098552)	-	4.22	0.028	CD40, CD40LG