Disease table of STROKE, ISCHEMIC OMIM ID: 601367

Gene-disease associations table

GeneAssociated with STROKE, ISCHEMIC inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
PRKCHOMIMHGNC link14q23.11601367
F2OMIMHGNC link11p11.24613679, PS188050, 614390, 601367
ALOX5APOMIMHGNC link13q12.31601367
F5OMIMHGNC link1q24.25227400, PS188050, 614389, 601367, 600880
NOS3OMIMHGNC link7q36.14145500, PS189800, 104300, 601367

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
NFKB1NO306NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC62NOS3, ALOX5AP
RELANO302NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC62NOS3, ALOX5AP
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
ALOX5APYES3NFKB1, HIF1A, RELA0
NOS3YES11SP1, GATA4, HDAC1, DDIT3, ATF2, JUN, RELA, SP3, NFKB1, GATA2, KLF20
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
PRKCHNOS3No1HSP90AA1
F2F5Yes1F5
F2NOS3No1ST13

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
PRKCHF2No-3SRC, HRAS, MAPK1
PRKCHNOS3No-6PRKCD, PTK2B, VCAM1, SRC, ICAM1, RHOA
F2F5Yesactivation, binding11FN1, VWF, PROC, F13A1, F3, IGF2, F10, PROS1, SERPINE1, A2M, IGF1
F2NOS3No-12ANGPT1, ESR1, CXCL12, BDNF, DNM1, IGFBP3, RAF1, EDN1, IGF1, SRC, GNAI1, GNB1
ALOX5APNOS3No-1HIF1A
F5NOS3No-4TGFB1, KNG1, VEGFA, IGF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
F2F5Yes2F2, F5

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Complement and coagulation cascadeshsa046106.582F2, F5

NET-GE enrichment

Term New enriched termICP valueGenes
Complement and coagulation cascades (hsa04610) -6.580.02F2, F5
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
HemostasisR-HSA-1095823.984PRKCH, F2, F5, NOS3
Platelet activation, signaling and aggregationR-HSA-760025.153PRKCH, F2, F5
Signal TransductionR-HSA-1625821.783PRKCH, F2, NOS3
Signaling by GPCRR-HSA-3727902.682PRKCH, F2
GPCR downstream signalingR-HSA-3883963.072PRKCH, F2
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.262PRKCH, F2
G alpha (q) signalling eventsR-HSA-4164765.422PRKCH, F2
MetabolismR-HSA-14307282.342NOS3, ALOX5AP
Common Pathway of Fibrin Clot FormationR-HSA-1408758.522F2, F5
Formation of Fibrin Clot (Clotting Cascade)R-HSA-1408777.72F2, F5

NET-GE enrichment

Term New enriched termICP valueGenes
Gamma-carboxylation of protein precursors (R-HSA-159740) NEW9.810.002F2, F5
Platelet degranulation (R-HSA-114608) NEW6.680.01F2, F5, NOS3
Platelet activation, signaling and aggregation (R-HSA-76002) -5.150.011PRKCH, F2, F5, NOS3
Stimuli-sensing channels (R-HSA-2672351) NEW6.280.015PRKCH, F2, NOS3
Response to elevated platelet cytosolic Ca2+ (R-HSA-76005) NEW6.590.013F2, F5, NOS3
Hemostasis (R-HSA-109582) -3.980.004PRKCH, F2, F5, NOS3
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (R-HSA-159854) NEW9.520.003F2, F5
Removal of aminoterminal propeptides from gamma-carboxylated proteins (R-HSA-159782) NEW9.810.002F2, F5
Intrinsic Pathway of Fibrin Clot Formation (R-HSA-140837) NEW8.520.013F2, F5
Common Pathway of Fibrin Clot Formation (R-HSA-140875) -8.520.021F2, F5
Formation of Fibrin Clot (Clotting Cascade) (R-HSA-140877) -7.70.011F2, F5
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus (R-HSA-159763) NEW9.980.002F2, F5
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.185PRKCH, F2, F5, ALOX5AP, NOS3
protein binding (GO:0005515) 0.465PRKCH, F2, F5, ALOX5AP, NOS3
ion binding (GO:0043167) 1.365PRKCH, F2, F5, ALOX5AP, NOS3
catalytic activity (GO:0003824) 1.054PRKCH, F2, ALOX5AP, NOS3
metal ion binding (GO:0046872) 1.414PRKCH, F2, F5, NOS3
cation binding (GO:0043169) 1.44PRKCH, F2, F5, NOS3
anion binding (GO:0043168) 4.172NOS3, ALOX5AP
transition metal ion binding (GO:0046914) 2.482NOS3, F5
carbohydrate derivative binding (GO:0097367) 2.032PRKCH, NOS3
organic cyclic compound binding (GO:0097159) 1.052PRKCH, NOS3
carboxylic acid binding (GO:0031406) 4.642NOS3, ALOX5AP
enzyme binding (GO:0019899) 2.272PRKCH, ALOX5AP
nucleotide binding (GO:0000166) 1.962PRKCH, NOS3
small molecule binding (GO:0036094) 1.892PRKCH, NOS3
transferase activity (GO:0016740) 1.952PRKCH, ALOX5AP
ribonucleotide binding (GO:0032553) 2.192PRKCH, NOS3
heterocyclic compound binding (GO:1901363) 1.062PRKCH, NOS3
nucleoside phosphate binding (GO:1901265) 1.962PRKCH, NOS3
oxidoreductase activity (GO:0016491) 3.122NOS3, ALOX5AP

NET-GE enrichment

Term New enriched termICP valueGenes
serine-type endopeptidase activity (GO:0004252) NEW4.40.036F2, F5, NOS3
enzyme activator activity (GO:0008047) NEW3.560.035PRKCH, F2, ALOX5AP, NOS3
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
biological regulation (GO:0065007) 0.395PRKCH, F2, F5, ALOX5AP, NOS3
cellular process (GO:0009987) 0.265PRKCH, F2, NOS3, ALOX5AP, F5
single-organism cellular process (GO:0044763) 0.655PRKCH, F2, NOS3, ALOX5AP, F5
single-organism process (GO:0044699) 0.485PRKCH, F2, F5, ALOX5AP, NOS3
primary metabolic process (GO:0044238) 0.694PRKCH, F2, ALOX5AP, NOS3
multicellular organismal process (GO:0032501) 1.454F2, NOS3, ALOX5AP, F5
single-multicellular organism process (GO:0044707) 1.784F2, F5, ALOX5AP, NOS3
regulation of response to stimulus (GO:0048583) 1.544PRKCH, F2, ALOX5AP, NOS3
cellular metabolic process (GO:0044237) 0.694PRKCH, F2, ALOX5AP, NOS3
organic substance metabolic process (GO:0071704) 0.634PRKCH, F2, ALOX5AP, NOS3
metabolic process (GO:0008152) 0.584PRKCH, F2, ALOX5AP, NOS3
positive regulation of biological process (GO:0048518) 1.24PRKCH, F2, ALOX5AP, NOS3
regulation of biological process (GO:0050789) 0.454PRKCH, F2, ALOX5AP, NOS3
regulation of primary metabolic process (GO:0080090) 1.083PRKCH, F2, NOS3
regulation of metabolic process (GO:0019222) 1.023PRKCH, F2, NOS3
regulation of response to external stimulus (GO:0032101) 3.063F2, ALOX5AP, NOS3
positive regulation of response to stimulus (GO:0048584) 2.183PRKCH, F2, ALOX5AP
regulation of cellular metabolic process (GO:0031323) 1.073PRKCH, F2, NOS3
signal transduction (GO:0007165) 1.283PRKCH, F2, NOS3
regulation of signaling (GO:0023051) 1.723PRKCH, F2, NOS3
regulation of cell communication (GO:0010646) 1.733PRKCH, F2, NOS3
cellular component organization or biogenesis (GO:0071840) 1.223F5, ALOX5AP, NOS3
regulation of signal transduction (GO:0009966) 1.843PRKCH, F2, NOS3
positive regulation of multicellular organismal process (GO:0051240) 2.493PRKCH, F2, NOS3
cellular component organization (GO:0016043) 1.243F5, ALOX5AP, NOS3
positive regulation of molecular function (GO:0044093) 2.233PRKCH, NOS3, ALOX5AP
negative regulation of biological process (GO:0048519) 1.333PRKCH, F2, NOS3
regulation of molecular function (GO:0065009) 1.783PRKCH, NOS3, ALOX5AP
regulation of biological quality (GO:0065008) 1.683F2, F5, NOS3
regulation of cell proliferation (GO:0042127) 2.413PRKCH, F2, NOS3
regulation of body fluid levels (GO:0050878) 3.763F2, F5, NOS3
regulation of developmental process (GO:0050793) 2.13PRKCH, F2, NOS3
regulation of biosynthetic process (GO:0009889) 1.373PRKCH, F2, NOS3
regulation of cellular process (GO:0050794) 0.53PRKCH, F2, NOS3
cell activation (GO:0001775) 3.473PRKCH, F2, F5
regulation of multicellular organismal process (GO:0051239) 1.873PRKCH, F2, NOS3
platelet activation (GO:0030168) 4.963PRKCH, F2, F5
response to stimulus (GO:0050896) 1.223F2, ALOX5AP, NOS3
regulation of multicellular organismal development (GO:2000026) 2.313PRKCH, F2, NOS3
regulation of response to stress (GO:0080134) 2.533F2, ALOX5AP, NOS3
negative regulation of cellular process (GO:0048523) 1.413PRKCH, F2, NOS3
positive regulation of cellular process (GO:0048522) 1.33PRKCH, F2, NOS3
hemostasis (GO:0007599) 4.52F2, F5
regulation of transport (GO:0051049) 2.242F2, NOS3
negative regulation of response to stimulus (GO:0048585) 2.522F2, NOS3
blood coagulation (GO:0007596) 4.522F2, F5
circulatory system process (GO:0003013) 4.382NOS3, F5
small molecule metabolic process (GO:0044281) 2.382NOS3, ALOX5AP
cell surface receptor signaling pathway (GO:0007166) 2.092F2, NOS3
regulation of phosphate metabolic process (GO:0019220) 2.352F2, NOS3
cellular response to stimulus (GO:0051716) 1.972F2, ALOX5AP
positive regulation of signal transduction (GO:0009967) 2.52PRKCH, F2
negative regulation of platelet activation (GO:0010544) 6.842F2, NOS3
peptidyl-amino acid modification (GO:0018193) 2.982PRKCH, F2
regulation of metal ion transport (GO:0010959) 3.942F2, NOS3
cellular homeostasis (GO:0019725) 3.232F2, NOS3
regulation of macromolecule metabolic process (GO:0060255) 1.082PRKCH, F2
negative regulation of cell death (GO:0060548) 2.952PRKCH, NOS3
oxoacid metabolic process (GO:0043436) 3.122NOS3, ALOX5AP
oxidation-reduction process (GO:0055114) 2.912NOS3, ALOX5AP
system process (GO:0003008) 2.32NOS3, F5
organonitrogen compound metabolic process (GO:1901564) 2.322F2, NOS3
vesicle-mediated transport (GO:0016192) 2.722F2, F5
cell motility (GO:0048870) 3.022F2, NOS3
protein metabolic process (GO:0019538) 1.452PRKCH, F2
regulation of blood coagulation (GO:0030193) 5.262F2, NOS3
negative regulation of blood coagulation (GO:0030195) 5.882F2, NOS3
cellular component assembly (GO:0022607) 2.142F5, ALOX5AP
positive regulation of metabolic process (GO:0009893) 1.742F2, NOS3
positive regulation of biosynthetic process (GO:0009891) 2.292F2, NOS3
movement of cell or subcellular component (GO:0006928) 2.612F2, NOS3
nitrogen compound metabolic process (GO:0006807) 1.132F2, NOS3
intracellular signal transduction (GO:0035556) 2.392PRKCH, NOS3
regulation of apoptotic process (GO:0042981) 2.52PRKCH, NOS3
cellular protein metabolic process (GO:0044267) 1.632PRKCH, F2
ER to Golgi vesicle-mediated transport (GO:0006888) 4.72F2, F5
cellular macromolecule metabolic process (GO:0044260) 0.932PRKCH, F2
regulation of gliogenesis (GO:0014013) 5.212PRKCH, F2
macromolecular complex assembly (GO:0065003) 2.552F5, ALOX5AP
regulation of hemostasis (GO:1900046) 5.262F2, NOS3
negative regulation of hemostasis (GO:1900047) 5.882F2, NOS3
regulation of platelet activation (GO:0010543) 6.262F2, NOS3
cell migration (GO:0016477) 3.122F2, NOS3
regulation of anatomical structure morphogenesis (GO:0022603) 2.792F2, NOS3
regulation of catalytic activity (GO:0050790) 1.972NOS3, ALOX5AP
transport (GO:0006810) 1.512F2, F5
single-organism metabolic process (GO:0044710) 1.632NOS3, ALOX5AP
macromolecule modification (GO:0043412) 1.732PRKCH, F2
coagulation (GO:0050817) 4.512F2, F5
establishment of localization (GO:0051234) 1.482F2, F5
regulation of coagulation (GO:0050818) 5.222F2, NOS3
negative regulation of coagulation (GO:0050819) 5.822F2, NOS3
single-organism developmental process (GO:0044767) 1.492F2, NOS3
intracellular transport (GO:0046907) 2.672F2, F5
response to stress (GO:0006950) 1.82F2, NOS3
regulation of nervous system development (GO:0051960) 3.12PRKCH, F2
negative regulation of response to external stimulus (GO:0032102) 4.182F2, NOS3
positive regulation of response to external stimulus (GO:0032103) 4.172F2, ALOX5AP
regulation of cellular component organization (GO:0051128) 2.012PRKCH, F2
positive regulation of signaling (GO:0023056) 2.412PRKCH, F2
cellular biosynthetic process (GO:0044249) 1.372NOS3, ALOX5AP
cellular nitrogen compound metabolic process (GO:0034641) 1.222F2, NOS3
positive regulation of cell communication (GO:0010647) 2.412PRKCH, F2
positive regulation of catalytic activity (GO:0043085) 2.42NOS3, ALOX5AP
regulation of neurogenesis (GO:0050767) 3.212PRKCH, F2
positive regulation of phosphorus metabolic process (GO:0010562) 2.782F2, NOS3
negative regulation of multicellular organismal process (GO:0051241) 2.842F2, NOS3
regulation of cell development (GO:0060284) 3.012PRKCH, F2
macromolecular complex subunit organization (GO:0043933) 2.142F5, ALOX5AP
protein modification process (GO:0036211) 1.792PRKCH, F2
regulation of response to wounding (GO:1903034) 4.742F2, NOS3
negative regulation of response to wounding (GO:1903035) 5.542F2, NOS3
developmental process (GO:0032502) 1.362F2, NOS3
locomotion (GO:0040011) 2.912F2, NOS3
regulation of macromolecule biosynthetic process (GO:0010556) 1.432PRKCH, F2
regulation of cell differentiation (GO:0045595) 2.422PRKCH, F2
regulation of localization (GO:0032879) 1.942F2, NOS3
organic acid metabolic process (GO:0006082) 3.012NOS3, ALOX5AP
positive regulation of developmental process (GO:0051094) 2.772PRKCH, NOS3
macromolecule metabolic process (GO:0043170) 0.832PRKCH, F2
positive regulation of cell proliferation (GO:0008284) 3.012PRKCH, F2
anatomical structure development (GO:0048856) 1.582F2, NOS3
regulation of cell activation (GO:0050865) 3.532F2, NOS3
regulation of cellular biosynthetic process (GO:0031326) 1.382PRKCH, NOS3
positive regulation of cellular metabolic process (GO:0031325) 1.812F2, NOS3
negative regulation of cell activation (GO:0050866) 4.672F2, NOS3
carboxylic acid metabolic process (GO:0019752) 3.122NOS3, ALOX5AP
homeostatic process (GO:0042592) 2.612F2, NOS3
regulation of wound healing (GO:0061041) 4.882F2, NOS3
negative regulation of wound healing (GO:0061045) 5.652F2, NOS3
regulation of cell death (GO:0010941) 2.432PRKCH, NOS3
multicellular organism development (GO:0007275) 2.542F2, NOS3
regulation of ion transport (GO:0043269) 3.42F2, NOS3
protein complex subunit organization (GO:0071822) 2.62F5, ALOX5AP
regulation of programmed cell death (GO:0043067) 2.492PRKCH, NOS3
negative regulation of apoptotic process (GO:0043066) 3.042PRKCH, NOS3
negative regulation of programmed cell death (GO:0043069) 3.022PRKCH, NOS3
regulation of gene expression (GO:0010468) 1.372PRKCH, F2
positive regulation of phosphate metabolic process (GO:0045937) 2.782F2, NOS3
Golgi vesicle transport (GO:0048193) 4.072F2, F5
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432PRKCH, NOS3
protein complex assembly (GO:0006461) 2.782F5, ALOX5AP
cellular protein modification process (GO:0006464) 1.792PRKCH, F2
regulation of phosphorus metabolic process (GO:0051174) 2.352F2, NOS3
biosynthetic process (GO:0009058) 1.322NOS3, ALOX5AP
regulation of nitrogen compound metabolic process (GO:0051171) 1.362PRKCH, NOS3
establishment of localization in cell (GO:0051649) 2.472F2, F5
localization (GO:0051179) 1.42F2, F5
cellular localization (GO:0051641) 2.322F2, F5
organelle organization (GO:0006996) 2.022NOS3, F5
response to abiotic stimulus (GO:0009628) 2.82F2, NOS3
regulation of calcium ion transport (GO:0051924) 4.382F2, NOS3

NET-GE enrichment

Term New enriched termICP valueGenes
hemostasis (GO:0007599) -4.50.001PRKCH, F2, F5, NOS3
blood coagulation (GO:0007596) -4.520.001PRKCH, F2, F5, NOS3
circulatory system process (GO:0003013) -4.380.002PRKCH, F2, F5, NOS3
protein carboxylation (GO:0018214) NEW7.330.015F2, F5
negative regulation of platelet activation (GO:0010544) -6.840.013F2, NOS3
regulation of hemostasis (GO:1900046) -5.260.032F2, F5, NOS3
negative regulation of hemostasis (GO:1900047) -5.880.002F2, F5, NOS3
regulation of platelet activation (GO:0010543) -6.260.01F2, NOS3
regulation of response to wounding (GO:1903034) -4.740.03F2, ALOX5AP, NOS3
regulation of calcium ion transport into cytosol (GO:0010522) NEW5.230.016PRKCH, F2, NOS3
regulation of body fluid levels (GO:0050878) -3.760.002PRKCH, F2, F5, NOS3
calcium-mediated signaling (GO:0019722) NEW5.240.027PRKCH, F2, NOS3
blood circulation (GO:0008015) NEW5.970.005F2, F5, NOS3
coagulation (GO:0050817) -4.510.001PRKCH, F2, F5, NOS3
response to metal ion (GO:0010038) NEW3.910.032F2, F5, ALOX5AP, NOS3
response to heat (GO:0009408) NEW5.240.024PRKCH, F2, NOS3
response to inorganic substance (GO:0010035) NEW3.560.002PRKCH, F2, F5, ALOX5AP, NOS3
regulation of coagulation (GO:0050818) -5.220.038F2, F5, NOS3
negative regulation of coagulation (GO:0050819) -5.820.023F2, F5, NOS3
platelet activation (GO:0030168) -4.960.006PRKCH, F2, F5, NOS3
peptidyl-glutamic acid carboxylation (GO:0017187) NEW7.330.015F2, F5
protein kinase C signaling (GO:0070528) NEW7.020.032PRKCH, NOS3
regulation of blood coagulation (GO:0030193) -5.260.032F2, F5, NOS3
platelet degranulation (GO:0002576) NEW5.120.017F2, F5, NOS3
negative regulation of blood coagulation (GO:0030195) -5.880.002F2, F5, NOS3
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
membrane (GO:0016020) 0.685PRKCH, F2, NOS3, ALOX5AP, F5
cell part (GO:0044464) 0.115PRKCH, F2, F5, ALOX5AP, NOS3
cytoplasmic part (GO:0044444) 0.825PRKCH, F2, F5, ALOX5AP, NOS3
intracellular part (GO:0044424) 0.285PRKCH, F2, F5, ALOX5AP, NOS3
membrane-bounded organelle (GO:0043227) 0.475PRKCH, F2, NOS3, ALOX5AP, F5
organelle (GO:0043226) 0.45PRKCH, F2, NOS3, ALOX5AP, F5
intracellular organelle part (GO:0044446) 0.814F2, NOS3, ALOX5AP, F5
organelle part (GO:0044422) 0.794F2, F5, ALOX5AP, NOS3
plasma membrane (GO:0005886) 1.394PRKCH, F2, F5, NOS3
intracellular membrane-bounded organelle (GO:0043231) 0.63NOS3, ALOX5AP, F5
extracellular organelle (GO:0043230) 1.893PRKCH, F2, F5
organelle membrane (GO:0031090) 1.973NOS3, ALOX5AP, F5
cytosol (GO:0005829) 1.683PRKCH, NOS3, ALOX5AP
intracellular organelle (GO:0043229) 0.513F5, ALOX5AP, NOS3
membrane-bounded vesicle (GO:0031988) 1.713PRKCH, F2, F5
endoplasmic reticulum part (GO:0044432) 2.733F2, ALOX5AP, F5
Golgi apparatus part (GO:0044431) 3.03F2, F5, NOS3
extracellular vesicle (GO:1903561) 1.893PRKCH, F2, F5
extracellular region part (GO:0044421) 1.573PRKCH, F2, F5
vesicle (GO:0031982) 1.643PRKCH, F2, F5
cytoplasm (GO:0005737) 1.012PRKCH, NOS3
extracellular space (GO:0005615) 2.632F2, F5
organelle lumen (GO:0043233) 3.052F2, F5
nucleus (GO:0005634) 1.072NOS3, ALOX5AP
membrane-enclosed lumen (GO:0031974) 3.052F2, F5
Golgi membrane (GO:0000139) 3.282NOS3, F5
cytoplasmic vesicle part (GO:0044433) 3.412NOS3, F5
intracellular organelle lumen (GO:0070013) 3.052F2, F5
extracellular region (GO:0005576) 2.182F2, F5
endoplasmic reticulum lumen (GO:0005788) 4.52F2, F5
membrane part (GO:0044425) 0.952NOS3, ALOX5AP
bounding membrane of organelle (GO:0098588) 2.392NOS3, F5
extracellular exosome (GO:0070062) 1.892PRKCH, F2

NET-GE enrichment

Term New enriched termICP valueGenes
Golgi lumen (GO:0005796) NEW5.280.003F2, F5, NOS3
vesicle lumen (GO:0031983) NEW5.170.001F2, F5, NOS3
platelet alpha granule lumen (GO:0031093) NEW5.810.018F2, F5
T-tubule (GO:0030315) NEW6.090.04PRKCH, NOS3
membrane region (GO:0098589) NEW3.950.041PRKCH, F2, NOS3, ALOX5AP, F5
blood microparticle (GO:0072562) NEW4.880.017F2, F5, NOS3
endoplasmic reticulum part (GO:0044432) -2.730.01PRKCH, F2, NOS3, ALOX5AP, F5
endoplasmic reticulum lumen (GO:0005788) -4.50.0PRKCH, F2, F5, NOS3
cytoplasmic membrane-bounded vesicle lumen (GO:0060205) NEW5.190.001F2, F5, NOS3
secretory granule lumen (GO:0034774) NEW5.380.049F2, F5