Disease table of STROKE, ISCHEMIC OMIM ID: 601367

Gene-disease associations table

Gene	Associated with STROKE, ISCHEMIC in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
PRKCH	OMIM	HGNC link	14q23.1	1	601367
F2	OMIM	HGNC link	11p11.2	4	613679, PS188050, 614390, 601367
ALOX5AP	OMIM	HGNC link	13q12.3	1	601367
F5	OMIM	HGNC link	1q24.2	5	227400, PS188050, 614389, 601367, 600880
NOS3	OMIM	HGNC link	7q36.1	4	145500, PS189800, 104300, 601367

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	2	NOS3, ALOX5AP
RELA	NO	302	NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC6	2	NOS3, ALOX5AP

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
ALOX5AP	YES	3	NFKB1, HIF1A, RELA	0
NOS3	YES	11	SP1, GATA4, HDAC1, DDIT3, ATF2, JUN, RELA, SP3, NFKB1, GATA2, KLF2	0

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
PRKCH	NOS3	No	1	HSP90AA1
F2	F5	Yes	1	F5
F2	NOS3	No	1	ST13

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
PRKCH	F2	No	-	3	SRC, HRAS, MAPK1
PRKCH	NOS3	No	-	6	PRKCD, PTK2B, VCAM1, SRC, ICAM1, RHOA
F2	F5	Yes	activation, binding	11	FN1, VWF, PROC, F13A1, F3, IGF2, F10, PROS1, SERPINE1, A2M, IGF1
F2	NOS3	No	-	12	ANGPT1, ESR1, CXCL12, BDNF, DNM1, IGFBP3, RAF1, EDN1, IGF1, SRC, GNAI1, GNB1
ALOX5AP	NOS3	No	-	1	HIF1A
F5	NOS3	No	-	4	TGFB1, KNG1, VEGFA, IGF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
F2	F5	Yes	2	F2, F5

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Complement and coagulation cascades	hsa04610	6.58	2	F2, F5

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Complement and coagulation cascades (hsa04610)	-	6.58	0.02	F2, F5

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Hemostasis	R-HSA-109582	3.98	4	PRKCH, F2, F5, NOS3
Platelet activation, signaling and aggregation	R-HSA-76002	5.15	3	PRKCH, F2, F5
Signal Transduction	R-HSA-162582	1.78	3	PRKCH, F2, NOS3
Signaling by GPCR	R-HSA-372790	2.68	2	PRKCH, F2
GPCR downstream signaling	R-HSA-388396	3.07	2	PRKCH, F2
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26	2	PRKCH, F2
G alpha (q) signalling events	R-HSA-416476	5.42	2	PRKCH, F2
Metabolism	R-HSA-1430728	2.34	2	NOS3, ALOX5AP
Common Pathway of Fibrin Clot Formation	R-HSA-140875	8.52	2	F2, F5
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	7.7	2	F2, F5

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Gamma-carboxylation of protein precursors (R-HSA-159740)	NEW	9.81	0.002	F2, F5
Platelet degranulation (R-HSA-114608)	NEW	6.68	0.01	F2, F5, NOS3
Platelet activation, signaling and aggregation (R-HSA-76002)	-	5.15	0.011	PRKCH, F2, F5, NOS3
Stimuli-sensing channels (R-HSA-2672351)	NEW	6.28	0.015	PRKCH, F2, NOS3
Response to elevated platelet cytosolic Ca2+ (R-HSA-76005)	NEW	6.59	0.013	F2, F5, NOS3
Hemostasis (R-HSA-109582)	-	3.98	0.004	PRKCH, F2, F5, NOS3
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (R-HSA-159854)	NEW	9.52	0.003	F2, F5
Removal of aminoterminal propeptides from gamma-carboxylated proteins (R-HSA-159782)	NEW	9.81	0.002	F2, F5
Intrinsic Pathway of Fibrin Clot Formation (R-HSA-140837)	NEW	8.52	0.013	F2, F5
Common Pathway of Fibrin Clot Formation (R-HSA-140875)	-	8.52	0.021	F2, F5
Formation of Fibrin Clot (Clotting Cascade) (R-HSA-140877)	-	7.7	0.011	F2, F5
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus (R-HSA-159763)	NEW	9.98	0.002	F2, F5

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	5	PRKCH, F2, F5, ALOX5AP, NOS3
protein binding (GO:0005515)	0.46	5	PRKCH, F2, F5, ALOX5AP, NOS3
ion binding (GO:0043167)	1.36	5	PRKCH, F2, F5, ALOX5AP, NOS3
catalytic activity (GO:0003824)	1.05	4	PRKCH, F2, ALOX5AP, NOS3
metal ion binding (GO:0046872)	1.41	4	PRKCH, F2, F5, NOS3
cation binding (GO:0043169)	1.4	4	PRKCH, F2, F5, NOS3
anion binding (GO:0043168)	4.17	2	NOS3, ALOX5AP
transition metal ion binding (GO:0046914)	2.48	2	NOS3, F5
carbohydrate derivative binding (GO:0097367)	2.03	2	PRKCH, NOS3
organic cyclic compound binding (GO:0097159)	1.05	2	PRKCH, NOS3
carboxylic acid binding (GO:0031406)	4.64	2	NOS3, ALOX5AP
enzyme binding (GO:0019899)	2.27	2	PRKCH, ALOX5AP
nucleotide binding (GO:0000166)	1.96	2	PRKCH, NOS3
small molecule binding (GO:0036094)	1.89	2	PRKCH, NOS3
transferase activity (GO:0016740)	1.95	2	PRKCH, ALOX5AP
ribonucleotide binding (GO:0032553)	2.19	2	PRKCH, NOS3
heterocyclic compound binding (GO:1901363)	1.06	2	PRKCH, NOS3
nucleoside phosphate binding (GO:1901265)	1.96	2	PRKCH, NOS3
oxidoreductase activity (GO:0016491)	3.12	2	NOS3, ALOX5AP

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
serine-type endopeptidase activity (GO:0004252)	NEW	4.4	0.036	F2, F5, NOS3
enzyme activator activity (GO:0008047)	NEW	3.56	0.035	PRKCH, F2, ALOX5AP, NOS3

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
biological regulation (GO:0065007)	0.39	5	PRKCH, F2, F5, ALOX5AP, NOS3
cellular process (GO:0009987)	0.26	5	PRKCH, F2, NOS3, ALOX5AP, F5
single-organism cellular process (GO:0044763)	0.65	5	PRKCH, F2, NOS3, ALOX5AP, F5
single-organism process (GO:0044699)	0.48	5	PRKCH, F2, F5, ALOX5AP, NOS3
primary metabolic process (GO:0044238)	0.69	4	PRKCH, F2, ALOX5AP, NOS3
multicellular organismal process (GO:0032501)	1.45	4	F2, NOS3, ALOX5AP, F5
single-multicellular organism process (GO:0044707)	1.78	4	F2, F5, ALOX5AP, NOS3
regulation of response to stimulus (GO:0048583)	1.54	4	PRKCH, F2, ALOX5AP, NOS3
cellular metabolic process (GO:0044237)	0.69	4	PRKCH, F2, ALOX5AP, NOS3
organic substance metabolic process (GO:0071704)	0.63	4	PRKCH, F2, ALOX5AP, NOS3
metabolic process (GO:0008152)	0.58	4	PRKCH, F2, ALOX5AP, NOS3
positive regulation of biological process (GO:0048518)	1.2	4	PRKCH, F2, ALOX5AP, NOS3
regulation of biological process (GO:0050789)	0.45	4	PRKCH, F2, ALOX5AP, NOS3
regulation of primary metabolic process (GO:0080090)	1.08	3	PRKCH, F2, NOS3
regulation of metabolic process (GO:0019222)	1.02	3	PRKCH, F2, NOS3
regulation of response to external stimulus (GO:0032101)	3.06	3	F2, ALOX5AP, NOS3
positive regulation of response to stimulus (GO:0048584)	2.18	3	PRKCH, F2, ALOX5AP
regulation of cellular metabolic process (GO:0031323)	1.07	3	PRKCH, F2, NOS3
signal transduction (GO:0007165)	1.28	3	PRKCH, F2, NOS3
regulation of signaling (GO:0023051)	1.72	3	PRKCH, F2, NOS3
regulation of cell communication (GO:0010646)	1.73	3	PRKCH, F2, NOS3
cellular component organization or biogenesis (GO:0071840)	1.22	3	F5, ALOX5AP, NOS3
regulation of signal transduction (GO:0009966)	1.84	3	PRKCH, F2, NOS3
positive regulation of multicellular organismal process (GO:0051240)	2.49	3	PRKCH, F2, NOS3
cellular component organization (GO:0016043)	1.24	3	F5, ALOX5AP, NOS3
positive regulation of molecular function (GO:0044093)	2.23	3	PRKCH, NOS3, ALOX5AP
negative regulation of biological process (GO:0048519)	1.33	3	PRKCH, F2, NOS3
regulation of molecular function (GO:0065009)	1.78	3	PRKCH, NOS3, ALOX5AP
regulation of biological quality (GO:0065008)	1.68	3	F2, F5, NOS3
regulation of cell proliferation (GO:0042127)	2.41	3	PRKCH, F2, NOS3
regulation of body fluid levels (GO:0050878)	3.76	3	F2, F5, NOS3
regulation of developmental process (GO:0050793)	2.1	3	PRKCH, F2, NOS3
regulation of biosynthetic process (GO:0009889)	1.37	3	PRKCH, F2, NOS3
regulation of cellular process (GO:0050794)	0.5	3	PRKCH, F2, NOS3
cell activation (GO:0001775)	3.47	3	PRKCH, F2, F5
regulation of multicellular organismal process (GO:0051239)	1.87	3	PRKCH, F2, NOS3
platelet activation (GO:0030168)	4.96	3	PRKCH, F2, F5
response to stimulus (GO:0050896)	1.22	3	F2, ALOX5AP, NOS3
regulation of multicellular organismal development (GO:2000026)	2.31	3	PRKCH, F2, NOS3
regulation of response to stress (GO:0080134)	2.53	3	F2, ALOX5AP, NOS3
negative regulation of cellular process (GO:0048523)	1.41	3	PRKCH, F2, NOS3
positive regulation of cellular process (GO:0048522)	1.3	3	PRKCH, F2, NOS3
hemostasis (GO:0007599)	4.5	2	F2, F5
regulation of transport (GO:0051049)	2.24	2	F2, NOS3
negative regulation of response to stimulus (GO:0048585)	2.52	2	F2, NOS3
blood coagulation (GO:0007596)	4.52	2	F2, F5
circulatory system process (GO:0003013)	4.38	2	NOS3, F5
small molecule metabolic process (GO:0044281)	2.38	2	NOS3, ALOX5AP
cell surface receptor signaling pathway (GO:0007166)	2.09	2	F2, NOS3
regulation of phosphate metabolic process (GO:0019220)	2.35	2	F2, NOS3
cellular response to stimulus (GO:0051716)	1.97	2	F2, ALOX5AP
positive regulation of signal transduction (GO:0009967)	2.5	2	PRKCH, F2
negative regulation of platelet activation (GO:0010544)	6.84	2	F2, NOS3
peptidyl-amino acid modification (GO:0018193)	2.98	2	PRKCH, F2
regulation of metal ion transport (GO:0010959)	3.94	2	F2, NOS3
cellular homeostasis (GO:0019725)	3.23	2	F2, NOS3
regulation of macromolecule metabolic process (GO:0060255)	1.08	2	PRKCH, F2
negative regulation of cell death (GO:0060548)	2.95	2	PRKCH, NOS3
oxoacid metabolic process (GO:0043436)	3.12	2	NOS3, ALOX5AP
oxidation-reduction process (GO:0055114)	2.91	2	NOS3, ALOX5AP
system process (GO:0003008)	2.3	2	NOS3, F5
organonitrogen compound metabolic process (GO:1901564)	2.32	2	F2, NOS3
vesicle-mediated transport (GO:0016192)	2.72	2	F2, F5
cell motility (GO:0048870)	3.02	2	F2, NOS3
protein metabolic process (GO:0019538)	1.45	2	PRKCH, F2
regulation of blood coagulation (GO:0030193)	5.26	2	F2, NOS3
negative regulation of blood coagulation (GO:0030195)	5.88	2	F2, NOS3
cellular component assembly (GO:0022607)	2.14	2	F5, ALOX5AP
positive regulation of metabolic process (GO:0009893)	1.74	2	F2, NOS3
positive regulation of biosynthetic process (GO:0009891)	2.29	2	F2, NOS3
movement of cell or subcellular component (GO:0006928)	2.61	2	F2, NOS3
nitrogen compound metabolic process (GO:0006807)	1.13	2	F2, NOS3
intracellular signal transduction (GO:0035556)	2.39	2	PRKCH, NOS3
regulation of apoptotic process (GO:0042981)	2.5	2	PRKCH, NOS3
cellular protein metabolic process (GO:0044267)	1.63	2	PRKCH, F2
ER to Golgi vesicle-mediated transport (GO:0006888)	4.7	2	F2, F5
cellular macromolecule metabolic process (GO:0044260)	0.93	2	PRKCH, F2
regulation of gliogenesis (GO:0014013)	5.21	2	PRKCH, F2
macromolecular complex assembly (GO:0065003)	2.55	2	F5, ALOX5AP
regulation of hemostasis (GO:1900046)	5.26	2	F2, NOS3
negative regulation of hemostasis (GO:1900047)	5.88	2	F2, NOS3
regulation of platelet activation (GO:0010543)	6.26	2	F2, NOS3
cell migration (GO:0016477)	3.12	2	F2, NOS3
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	2	F2, NOS3
regulation of catalytic activity (GO:0050790)	1.97	2	NOS3, ALOX5AP
transport (GO:0006810)	1.51	2	F2, F5
single-organism metabolic process (GO:0044710)	1.63	2	NOS3, ALOX5AP
macromolecule modification (GO:0043412)	1.73	2	PRKCH, F2
coagulation (GO:0050817)	4.51	2	F2, F5
establishment of localization (GO:0051234)	1.48	2	F2, F5
regulation of coagulation (GO:0050818)	5.22	2	F2, NOS3
negative regulation of coagulation (GO:0050819)	5.82	2	F2, NOS3
single-organism developmental process (GO:0044767)	1.49	2	F2, NOS3
intracellular transport (GO:0046907)	2.67	2	F2, F5
response to stress (GO:0006950)	1.8	2	F2, NOS3
regulation of nervous system development (GO:0051960)	3.1	2	PRKCH, F2
negative regulation of response to external stimulus (GO:0032102)	4.18	2	F2, NOS3
positive regulation of response to external stimulus (GO:0032103)	4.17	2	F2, ALOX5AP
regulation of cellular component organization (GO:0051128)	2.01	2	PRKCH, F2
positive regulation of signaling (GO:0023056)	2.41	2	PRKCH, F2
cellular biosynthetic process (GO:0044249)	1.37	2	NOS3, ALOX5AP
cellular nitrogen compound metabolic process (GO:0034641)	1.22	2	F2, NOS3
positive regulation of cell communication (GO:0010647)	2.41	2	PRKCH, F2
positive regulation of catalytic activity (GO:0043085)	2.4	2	NOS3, ALOX5AP
regulation of neurogenesis (GO:0050767)	3.21	2	PRKCH, F2
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	2	F2, NOS3
negative regulation of multicellular organismal process (GO:0051241)	2.84	2	F2, NOS3
regulation of cell development (GO:0060284)	3.01	2	PRKCH, F2
macromolecular complex subunit organization (GO:0043933)	2.14	2	F5, ALOX5AP
protein modification process (GO:0036211)	1.79	2	PRKCH, F2
regulation of response to wounding (GO:1903034)	4.74	2	F2, NOS3
negative regulation of response to wounding (GO:1903035)	5.54	2	F2, NOS3
developmental process (GO:0032502)	1.36	2	F2, NOS3
locomotion (GO:0040011)	2.91	2	F2, NOS3
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	2	PRKCH, F2
regulation of cell differentiation (GO:0045595)	2.42	2	PRKCH, F2
regulation of localization (GO:0032879)	1.94	2	F2, NOS3
organic acid metabolic process (GO:0006082)	3.01	2	NOS3, ALOX5AP
positive regulation of developmental process (GO:0051094)	2.77	2	PRKCH, NOS3
macromolecule metabolic process (GO:0043170)	0.83	2	PRKCH, F2
positive regulation of cell proliferation (GO:0008284)	3.01	2	PRKCH, F2
anatomical structure development (GO:0048856)	1.58	2	F2, NOS3
regulation of cell activation (GO:0050865)	3.53	2	F2, NOS3
regulation of cellular biosynthetic process (GO:0031326)	1.38	2	PRKCH, NOS3
positive regulation of cellular metabolic process (GO:0031325)	1.81	2	F2, NOS3
negative regulation of cell activation (GO:0050866)	4.67	2	F2, NOS3
carboxylic acid metabolic process (GO:0019752)	3.12	2	NOS3, ALOX5AP
homeostatic process (GO:0042592)	2.61	2	F2, NOS3
regulation of wound healing (GO:0061041)	4.88	2	F2, NOS3
negative regulation of wound healing (GO:0061045)	5.65	2	F2, NOS3
regulation of cell death (GO:0010941)	2.43	2	PRKCH, NOS3
multicellular organism development (GO:0007275)	2.54	2	F2, NOS3
regulation of ion transport (GO:0043269)	3.4	2	F2, NOS3
protein complex subunit organization (GO:0071822)	2.6	2	F5, ALOX5AP
regulation of programmed cell death (GO:0043067)	2.49	2	PRKCH, NOS3
negative regulation of apoptotic process (GO:0043066)	3.04	2	PRKCH, NOS3
negative regulation of programmed cell death (GO:0043069)	3.02	2	PRKCH, NOS3
regulation of gene expression (GO:0010468)	1.37	2	PRKCH, F2
positive regulation of phosphate metabolic process (GO:0045937)	2.78	2	F2, NOS3
Golgi vesicle transport (GO:0048193)	4.07	2	F2, F5
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	2	PRKCH, NOS3
protein complex assembly (GO:0006461)	2.78	2	F5, ALOX5AP
cellular protein modification process (GO:0006464)	1.79	2	PRKCH, F2
regulation of phosphorus metabolic process (GO:0051174)	2.35	2	F2, NOS3
biosynthetic process (GO:0009058)	1.32	2	NOS3, ALOX5AP
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	2	PRKCH, NOS3
establishment of localization in cell (GO:0051649)	2.47	2	F2, F5
localization (GO:0051179)	1.4	2	F2, F5
cellular localization (GO:0051641)	2.32	2	F2, F5
organelle organization (GO:0006996)	2.02	2	NOS3, F5
response to abiotic stimulus (GO:0009628)	2.8	2	F2, NOS3
regulation of calcium ion transport (GO:0051924)	4.38	2	F2, NOS3

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
hemostasis (GO:0007599)	-	4.5	0.001	PRKCH, F2, F5, NOS3
blood coagulation (GO:0007596)	-	4.52	0.001	PRKCH, F2, F5, NOS3
circulatory system process (GO:0003013)	-	4.38	0.002	PRKCH, F2, F5, NOS3
protein carboxylation (GO:0018214)	NEW	7.33	0.015	F2, F5
negative regulation of platelet activation (GO:0010544)	-	6.84	0.013	F2, NOS3
regulation of hemostasis (GO:1900046)	-	5.26	0.032	F2, F5, NOS3
negative regulation of hemostasis (GO:1900047)	-	5.88	0.002	F2, F5, NOS3
regulation of platelet activation (GO:0010543)	-	6.26	0.01	F2, NOS3
regulation of response to wounding (GO:1903034)	-	4.74	0.03	F2, ALOX5AP, NOS3
regulation of calcium ion transport into cytosol (GO:0010522)	NEW	5.23	0.016	PRKCH, F2, NOS3
regulation of body fluid levels (GO:0050878)	-	3.76	0.002	PRKCH, F2, F5, NOS3
calcium-mediated signaling (GO:0019722)	NEW	5.24	0.027	PRKCH, F2, NOS3
blood circulation (GO:0008015)	NEW	5.97	0.005	F2, F5, NOS3
coagulation (GO:0050817)	-	4.51	0.001	PRKCH, F2, F5, NOS3
response to metal ion (GO:0010038)	NEW	3.91	0.032	F2, F5, ALOX5AP, NOS3
response to heat (GO:0009408)	NEW	5.24	0.024	PRKCH, F2, NOS3
response to inorganic substance (GO:0010035)	NEW	3.56	0.002	PRKCH, F2, F5, ALOX5AP, NOS3
regulation of coagulation (GO:0050818)	-	5.22	0.038	F2, F5, NOS3
negative regulation of coagulation (GO:0050819)	-	5.82	0.023	F2, F5, NOS3
platelet activation (GO:0030168)	-	4.96	0.006	PRKCH, F2, F5, NOS3
peptidyl-glutamic acid carboxylation (GO:0017187)	NEW	7.33	0.015	F2, F5
protein kinase C signaling (GO:0070528)	NEW	7.02	0.032	PRKCH, NOS3
regulation of blood coagulation (GO:0030193)	-	5.26	0.032	F2, F5, NOS3
platelet degranulation (GO:0002576)	NEW	5.12	0.017	F2, F5, NOS3
negative regulation of blood coagulation (GO:0030195)	-	5.88	0.002	F2, F5, NOS3

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
membrane (GO:0016020)	0.68	5	PRKCH, F2, NOS3, ALOX5AP, F5
cell part (GO:0044464)	0.11	5	PRKCH, F2, F5, ALOX5AP, NOS3
cytoplasmic part (GO:0044444)	0.82	5	PRKCH, F2, F5, ALOX5AP, NOS3
intracellular part (GO:0044424)	0.28	5	PRKCH, F2, F5, ALOX5AP, NOS3
membrane-bounded organelle (GO:0043227)	0.47	5	PRKCH, F2, NOS3, ALOX5AP, F5
organelle (GO:0043226)	0.4	5	PRKCH, F2, NOS3, ALOX5AP, F5
intracellular organelle part (GO:0044446)	0.81	4	F2, NOS3, ALOX5AP, F5
organelle part (GO:0044422)	0.79	4	F2, F5, ALOX5AP, NOS3
plasma membrane (GO:0005886)	1.39	4	PRKCH, F2, F5, NOS3
intracellular membrane-bounded organelle (GO:0043231)	0.6	3	NOS3, ALOX5AP, F5
extracellular organelle (GO:0043230)	1.89	3	PRKCH, F2, F5
organelle membrane (GO:0031090)	1.97	3	NOS3, ALOX5AP, F5
cytosol (GO:0005829)	1.68	3	PRKCH, NOS3, ALOX5AP
intracellular organelle (GO:0043229)	0.51	3	F5, ALOX5AP, NOS3
membrane-bounded vesicle (GO:0031988)	1.71	3	PRKCH, F2, F5
endoplasmic reticulum part (GO:0044432)	2.73	3	F2, ALOX5AP, F5
Golgi apparatus part (GO:0044431)	3.0	3	F2, F5, NOS3
extracellular vesicle (GO:1903561)	1.89	3	PRKCH, F2, F5
extracellular region part (GO:0044421)	1.57	3	PRKCH, F2, F5
vesicle (GO:0031982)	1.64	3	PRKCH, F2, F5
cytoplasm (GO:0005737)	1.01	2	PRKCH, NOS3
extracellular space (GO:0005615)	2.63	2	F2, F5
organelle lumen (GO:0043233)	3.05	2	F2, F5
nucleus (GO:0005634)	1.07	2	NOS3, ALOX5AP
membrane-enclosed lumen (GO:0031974)	3.05	2	F2, F5
Golgi membrane (GO:0000139)	3.28	2	NOS3, F5
cytoplasmic vesicle part (GO:0044433)	3.41	2	NOS3, F5
intracellular organelle lumen (GO:0070013)	3.05	2	F2, F5
extracellular region (GO:0005576)	2.18	2	F2, F5
endoplasmic reticulum lumen (GO:0005788)	4.5	2	F2, F5
membrane part (GO:0044425)	0.95	2	NOS3, ALOX5AP
bounding membrane of organelle (GO:0098588)	2.39	2	NOS3, F5
extracellular exosome (GO:0070062)	1.89	2	PRKCH, F2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Golgi lumen (GO:0005796)	NEW	5.28	0.003	F2, F5, NOS3
vesicle lumen (GO:0031983)	NEW	5.17	0.001	F2, F5, NOS3
platelet alpha granule lumen (GO:0031093)	NEW	5.81	0.018	F2, F5
T-tubule (GO:0030315)	NEW	6.09	0.04	PRKCH, NOS3
membrane region (GO:0098589)	NEW	3.95	0.041	PRKCH, F2, NOS3, ALOX5AP, F5
blood microparticle (GO:0072562)	NEW	4.88	0.017	F2, F5, NOS3
endoplasmic reticulum part (GO:0044432)	-	2.73	0.01	PRKCH, F2, NOS3, ALOX5AP, F5
endoplasmic reticulum lumen (GO:0005788)	-	4.5	0.0	PRKCH, F2, F5, NOS3
cytoplasmic membrane-bounded vesicle lumen (GO:0060205)	NEW	5.19	0.001	F2, F5, NOS3
secretory granule lumen (GO:0034774)	NEW	5.38	0.049	F2, F5