Disease table of OSTEOGENESIS IMPERFECTA OMIM ID: PS166200

Gene-disease associations table

Gene	Associated with OSTEOGENESIS IMPERFECTA in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
TMEM38B	OMIM	HGNC link	9q31.2	1	PS166200
IFITM5	ClinVar, OMIM, HUMSAVAR	HGNC link	11p15.5	1	PS166200
BMP1	ClinVar, OMIM, HUMSAVAR	HGNC link	8p21.3	1	PS166200
WNT1	ClinVar, OMIM, HUMSAVAR	HGNC link	12q13.12	3	166710, 615221, PS166200
FKBP10	ClinVar, OMIM	HGNC link	17q21.2	2	259450, PS166200
SPARC	OMIM, HUMSAVAR	HGNC link	5q33.1	1	PS166200
COL1A2	ClinVar, OMIM, HUMSAVAR	HGNC link	7q21.3	4	166710, PS166200, 225320, 130060
P3H1	ClinVar, OMIM	HGNC link	1p34.2	1	PS166200
COL1A1	ClinVar, OMIM, HUMSAVAR	HGNC link	17q21.33	5	166710, 130000, PS166200, 114000, 130060
SERPINF1	ClinVar, OMIM	HGNC link	17p13.3	1	PS166200
SERPINH1	ClinVar, OMIM, HUMSAVAR	HGNC link	11q13.5	2	PS166200, 610504
SP7	OMIM	HGNC link	12q13.13	1	PS166200
PPIB	ClinVar, OMIM, HUMSAVAR	HGNC link	15q22.31	1	PS166200
CRTAP	ClinVar, OMIM, HUMSAVAR	HGNC link	3p22.3	1	PS166200

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
12q13	2	WNT1, SP7
17q21	2	COL1A1, FKBP10

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
17q2	2	COL1A1, FKBP10
12q1	2	WNT1, SP7

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
12q	2	WNT1, SP7
17q	2	COL1A1, FKBP10

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
11	2	SERPINH1, IFITM5
12	2	WNT1, SP7
17	3	SERPINF1, COL1A1, FKBP10

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
SP7	YES	1	COL11A2	0
STAT6	NO	38	BCL2L1, CCL11, CYP2E1, ORMDL3, ALOX15, ITGA2B, ADRA2B, EGLN3, FOS, IL13, PTGS2, SELE, EGR1, ALOX12, NCOA3, SOCS1, CYSLTR1, STAT1, SIDT1, CCL26, COL1A2, HSD3B2, FOSB, CNR1, CISH, SELP, OPRM1, CXCL8, CD40, DUSP1, IL24, FCER2, IRF4, IL1R1, CCL17, IL4, RHOA, COL1A1	2	COL1A2, COL1A1
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	2	COL1A2, COL1A1
RELA	NO	302	NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC6	2	COL1A2, COL1A1
MYB	NO	33	COL1A2, MYB, COL1A1, IL7, CEBPA, CTSG, GSTM1, IL15, SIM2, ERBB2, RAG2, TK1, WAS, CLEC4G, CDO1, LCK, DHRS2, CD34, GATA1, ICAM1, ANPEP, GATA3, BCL2, NR3C1, CD4, CCNA1, CSF3R, ELANE, SP3, NMU, MYC, MAT2A, PRTN3	2	COL1A2, COL1A1
CIITA	NO	30	IRF2, HDAC2, COL1A2, HLA-DRB4, HLA-DRB1, HLA-DRB3, HLA-DRA, IL4, HLA-DMA, HLA-C, SIRT1, HLA-DQB1, HLA-B, SLC26A3, HLA-A, PLXNA1, COL1A1, HLA-DMB, HLA-DRB5, S100A4, MMP9, IRF1, PSMC5, HLA-DOB, HLA-DOA, HLA-DPB1, HLA-G, RAB4B, CREBBP, FASLG	2	COL1A2, COL1A1

regulated gene	associated to this disease	# TFs	TFs
SPARC	YES	2	VHL, SATB1
COL1A2	YES	9	RFX5, STAT6, YY1, CEBPZ, MYB, RELA, CIITA, NFKB1, SIRT1
COL1A1	YES	12	SP1, RELA, NFKB1, MYBL2, TFAP2A, SP3, MYB, NFIC, MKL1, CIITA, STAT6, ETS1
SERPINF1	YES	2	PARP1, MITF
SP7	YES	1	RUNX2

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
TMEM38B	COL1A1	No	1	ELAVL1
TMEM38B	SERPINH1	No	2	ENV, ELAVL1
TMEM38B	PPIB	No	1	TCTN3
BMP1	SERPINH1	No	1	TP53
WNT1	SERPINF1	No	1	LRP6
FKBP10	P3H1	Yes	7	SLC2A4, ZPR1, TCTN1, PPME1, LPP, HSPBP1, H2AFX
FKBP10	SERPINH1	No	2	SLC2A4, TCTN1
FKBP10	PPIB	No	1	TCTN1
FKBP10	CRTAP	No	1	P3H1
SPARC	COL1A2	No	3	PDGFB, COL1A1, UBQLN1
SPARC	COL1A1	Yes	2	PDGFB, COL1A1
SPARC	PPIB	No	1	UBQLN1
COL1A2	COL1A1	Yes	5	CAMKMT, ERAL1, PDGFA, PDGFB, COL1A1
COL1A2	SERPINF1	No	1	MYOC
COL1A2	PPIB	No	2	UBQLN1, SGTA
P3H1	SERPINH1	No	7	SLC2A4, PDIA6, TCTN1, FBXO6, NTRK1, MYC, P4HB
P3H1	PPIB	No	7	VHL, WDR48, TCTN1, WWOX, FBXO6, NTRK1, P4HB
P3H1	CRTAP	Yes	17	EDA, VHL, TOM1L1, VPS26A, WDR48, SF3A1, SRSF1, MBIP, TSC22D4, ACTR2, COL8A2, FBXO6, RNPS1, GPN1, NUDT21, SURF2, MIA3
COL1A1	SERPINH1	No	1	ELAVL1
SERPINH1	PPIB	No	16	OBSL1, SUGP1, ESR1, CDK2, TIMM44, MCM2, TCTN1, ZC3H11A, CUL7, UBQLN4, OS9, FBXO6, NTRK1, HSPA5, UBL4A, P4HB
SERPINH1	CRTAP	No	1	FBXO6
PPIB	CRTAP	No	3	VHL, WDR48, FBXO6

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
TMEM38B	SERPINH1	No	-	1	UBC
BMP1	WNT1	No	-	1	SFRP2
BMP1	SPARC	No	-	1	IGF1
BMP1	SP7	No	-	2	PTH, IGF1
WNT1	SPARC	No	-	1	SERPINE1
WNT1	SERPINF1	No	-	1	LRP6
WNT1	SP7	No	-	7	BMP2, LRP5, MYF5, SMAD4, SOST, DKK1, NOG
SPARC	SERPINF1	No	-	2	ALB, VEGFA
SPARC	SP7	No	-	1	IGF1
SERPINF1	SERPINH1	No	-	1	TP53
SERPINF1	SP7	No	-	1	TP53
SERPINH1	SP7	No	-	2	TP53, AKT1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
SERPINH1	PPIB	No	6	SUGP1, ZC3H11A, P4HB, HSPA5, UBL4A, TIMM44

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
COL1A2	COL1A1	Yes	5	COL9A2, COL9A3, COL1A2, COL9A1, COL1A1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Platelet activation	hsa04611	5.66	2	COL1A2, COL1A1
Protein digestion and absorption	hsa04974	6.2	2	COL1A2, COL1A1
ECM-receptor interaction	hsa04512	6.09	2	COL1A2, COL1A1
Focal adhesion	hsa04510	4.92	2	COL1A2, COL1A1
Amoebiasis	hsa05146	5.82	2	COL1A2, COL1A1
PI3K-Akt signaling pathway	hsa04151	4.21	2	COL1A2, COL1A1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Protein digestion and absorption (hsa04974)	-	6.2	0.016	COL1A2, COL1A1
ECM-receptor interaction (hsa04512)	-	6.09	0.026	COL1A2, COL1A1, SERPINH1
Focal adhesion (hsa04510)	-	4.92	0.048	SPARC, COL1A1, COL1A2, SERPINH1
Cellular community	NEW	3.57	0.018	WNT1, COL1A1, COL1A2
Amoebiasis (hsa05146)	-	5.82	0.027	COL1A2, COL1A1
Platelet activation (hsa04611)	-	5.66	0.035	COL1A2, COL1A1

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Extracellular matrix organization	R-HSA-1474244	4.91	8	SPARC, CRTAP, BMP1, SERPINH1, COL1A1, PPIB, COL1A2, P3H1
Collagen biosynthesis and modifying enzymes	R-HSA-1650814	6.98	7	COL1A2, CRTAP, BMP1, P3H1, SERPINH1, COL1A1, PPIB
Collagen formation	R-HSA-1474290	6.56	7	COL1A2, CRTAP, BMP1, P3H1, SERPINH1, COL1A1, PPIB
Platelet activation, signaling and aggregation	R-HSA-76002	5.15	3	SPARC, COL1A1, COL1A2
Anchoring fibril formation	R-HSA-2214320	9.08	3	COL1A2, COL1A1, BMP1
Crosslinking of collagen fibrils	R-HSA-2243919	9.52	3	COL1A2, COL1A1, BMP1
Degradation of the extracellular matrix	R-HSA-1474228	6.11	3	COL1A2, COL1A1, BMP1
ECM proteoglycans	R-HSA-3000178	6.75	3	SPARC, COL1A1, COL1A2
Assembly of collagen fibrils and other multimeric structures	R-HSA-2022090	7.2	3	COL1A2, COL1A1, BMP1
Hemostasis	R-HSA-109582	3.98	3	SPARC, COL1A1, COL1A2
Binding and Uptake of Ligands by Scavenger Receptors	R-HSA-2173782	5.38	3	SPARC, COL1A1, COL1A2
Vesicle-mediated transport	R-HSA-5653656	4.33	3	SPARC, COL1A1, COL1A2
Integrin cell surface interactions	R-HSA-216083	6.57	2	COL1A2, COL1A1
GPVI-mediated activation cascade	R-HSA-114604	7.18	2	COL1A2, COL1A1
Collagen degradation	R-HSA-1442490	7.03	2	COL1A2, COL1A1
Syndecan interactions	R-HSA-3000170	8.23	2	COL1A2, COL1A1
Scavenging by Class A Receptors	R-HSA-3000480	8.73	2	COL1A2, COL1A1
Non-integrin membrane-ECM interactions	R-HSA-3000171	7.1	2	COL1A2, COL1A1
Cell surface interactions at the vascular wall	R-HSA-202733	6.32	2	COL1A2, COL1A1
Platelet Adhesion to exposed collagen	R-HSA-75892	9.08	2	COL1A2, COL1A1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)	-	5.38	0.042	SPARC, COL1A1, COL1A2
Anchoring fibril formation (R-HSA-2214320)	-	9.08	0.0	COL1A2, COL1A1, BMP1
Crosslinking of collagen fibrils (R-HSA-2243919)	-	9.52	0.0	COL1A2, COL1A1, BMP1
Degradation of the extracellular matrix (R-HSA-1474228)	-	6.11	0.007	SPARC, COL1A1, COL1A2, BMP1
ECM proteoglycans (R-HSA-3000178)	-	6.75	0.003	SPARC, COL1A1, COL1A2, SERPINH1
Scavenging by Class A Receptors (R-HSA-3000480)	-	8.73	0.008	COL1A2, COL1A1
Extracellular matrix organization (R-HSA-1474244)	-	4.91	0.0	SPARC, CRTAP, BMP1, SERPINH1, COL1A1, PPIB, COL1A2, P3H1
Collagen formation (R-HSA-1474290)	-	6.56	0.0	COL1A2, CRTAP, BMP1, P3H1, SERPINH1, COL1A1, PPIB
Platelet Adhesion to exposed collagen (R-HSA-75892)	-	9.08	0.014	COL1A2, COL1A1
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)	-	6.98	0.0	COL1A2, CRTAP, BMP1, P3H1, SERPINH1, COL1A1, PPIB
Syndecan interactions (R-HSA-3000170)	-	8.23	0.04	COL1A2, COL1A1
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)	-	7.2	0.013	COL1A2, COL1A1, BMP1

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	12	SP7, P3H1, SPARC, CRTAP, WNT1, FKBP10, BMP1, SERPINH1, COL1A1, PPIB, COL1A2, SERPINF1
protein binding (GO:0005515)	0.46	11	SP7, SPARC, CRTAP, WNT1, BMP1, P3H1, SERPINH1, COL1A1, PPIB, COL1A2, SERPINF1
cation binding (GO:0043169)	1.4	7	SP7, COL1A2, FKBP10, BMP1, COL1A1, SPARC, P3H1
metal ion binding (GO:0046872)	1.41	7	SP7, COL1A2, FKBP10, BMP1, COL1A1, SPARC, P3H1
ion binding (GO:0043167)	1.36	7	SP7, COL1A2, FKBP10, BMP1, COL1A1, SPARC, P3H1
protein complex binding (GO:0032403)	3.09	5	CRTAP, SPARC, P3H1, PPIB, SERPINH1
organic cyclic compound binding (GO:0097159)	1.05	5	SP7, FKBP10, WNT1, PPIB, SERPINH1
macromolecular complex binding (GO:0044877)	2.61	5	CRTAP, SPARC, P3H1, PPIB, SERPINH1
heterocyclic compound binding (GO:1901363)	1.06	5	SP7, FKBP10, WNT1, PPIB, SERPINH1
catalytic activity (GO:0003824)	1.05	4	FKBP10, PPIB, P3H1, BMP1
collagen binding (GO:0005518)	5.58	4	SPARC, P3H1, PPIB, SERPINH1
nucleic acid binding (GO:0003676)	1.44	4	SP7, WNT1, PPIB, SERPINH1
molecular function regulator (GO:0098772)	2.51	3	WNT1, SERPINH1, SERPINF1
calcium ion binding (GO:0005509)	3.17	3	SPARC, FKBP10, BMP1
extracellular matrix structural constituent (GO:0005201)	5.37	2	COL1A2, COL1A1
cytokine activity (GO:0005125)	4.34	2	WNT1, BMP1
peptidase inhibitor activity (GO:0030414)	4.55	2	SERPINF1, SERPINH1
enzyme binding (GO:0019899)	2.27	2	SP7, PPIB
DNA binding (GO:0003677)	1.92	2	SP7, WNT1
enzyme inhibitor activity (GO:0004857)	3.78	2	SERPINF1, SERPINH1
transition metal ion binding (GO:0046914)	2.48	2	BMP1, P3H1
growth factor binding (GO:0019838)	4.89	2	COL1A2, COL1A1
unfolded protein binding (GO:0051082)	5.13	2	PPIB, SERPINH1
structural molecule activity (GO:0005198)	3.1	2	COL1A2, COL1A1
peptidyl-prolyl cis-trans isomerase activity (GO:0003755)	5.87	2	FKBP10, PPIB
enzyme regulator activity (GO:0030234)	2.85	2	SERPINF1, SERPINH1
identical protein binding (GO:0042802)	2.63	2	COL1A2, COL1A1
endopeptidase regulator activity (GO:0061135)	4.57	2	SERPINF1, SERPINH1
peptidase regulator activity (GO:0061134)	4.37	2	SERPINF1, SERPINH1
poly(A) RNA binding (GO:0044822)	2.69	2	PPIB, SERPINH1
endopeptidase inhibitor activity (GO:0004866)	4.6	2	SERPINF1, SERPINH1
serine-type endopeptidase inhibitor activity (GO:0004867)	5.16	2	SERPINF1, SERPINH1
isomerase activity (GO:0016853)	4.62	2	FKBP10, PPIB
cis-trans isomerase activity (GO:0016859)	5.83	2	FKBP10, PPIB
RNA binding (GO:0003723)	2.36	2	PPIB, SERPINH1
platelet-derived growth factor binding (GO:0048407)	7.34	2	COL1A2, COL1A1
receptor binding (GO:0005102)	2.43	2	WNT1, BMP1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
sulfur compound binding (GO:1901681)	NEW	4.32	0.014	SP7, SPARC, COL1A1, COL1A2, BMP1
L-ascorbic acid binding (GO:0031418)	NEW	6.69	0.047	COL1A1, P3H1
endopeptidase regulator activity (GO:0061135)	-	4.57	0.003	COL1A2, BMP1, COL1A1, SERPINH1, SERPINF1
peptidase regulator activity (GO:0061134)	-	4.37	0.009	COL1A2, BMP1, COL1A1, SERPINH1, SERPINF1
glycosaminoglycan binding (GO:0005539)	NEW	4.42	0.009	SP7, SPARC, COL1A1, COL1A2, BMP1
monosaccharide binding (GO:0048029)	NEW	5.85	0.0	COL1A2, COL1A1, P3H1, SERPINH1
peptidyl-prolyl cis-trans isomerase activity (GO:0003755)	-	5.87	0.05	FKBP10, PPIB
protein complex binding (GO:0032403)	-	3.09	0.015	SPARC, CRTAP, BMP1, SERPINH1, COL1A1, PPIB, COL1A2, P3H1
platelet-derived growth factor binding (GO:0048407)	-	7.34	0.002	COL1A2, COL1A1
collagen binding (GO:0005518)	-	5.58	0.0	COL1A2, BMP1, COL1A1, SPARC, SERPINH1
heparin binding (GO:0008201)	NEW	4.68	0.003	SP7, SPARC, COL1A1, COL1A2, BMP1

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	13	SP7, P3H1, SPARC, CRTAP, WNT1, FKBP10, SERPINF1, SERPINH1, TMEM38B, COL1A1, PPIB, COL1A2, BMP1
single-organism process (GO:0044699)	0.48	13	SP7, IFITM5, P3H1, SPARC, CRTAP, WNT1, SERPINF1, SERPINH1, TMEM38B, COL1A1, PPIB, COL1A2, BMP1
biological regulation (GO:0065007)	0.39	12	SP7, IFITM5, P3H1, SPARC, CRTAP, WNT1, BMP1, SERPINH1, COL1A1, PPIB, COL1A2, SERPINF1
regulation of biological process (GO:0050789)	0.45	12	SP7, IFITM5, P3H1, SPARC, CRTAP, WNT1, BMP1, SERPINH1, COL1A1, PPIB, COL1A2, SERPINF1
regulation of cellular process (GO:0050794)	0.5	11	SP7, SERPINF1, COL1A2, CRTAP, WNT1, BMP1, SERPINH1, COL1A1, PPIB, SPARC, P3H1
developmental process (GO:0032502)	1.36	10	IFITM5, SPARC, WNT1, BMP1, P3H1, SERPINH1, COL1A1, PPIB, COL1A2, SERPINF1
anatomical structure development (GO:0048856)	1.58	10	IFITM5, SPARC, WNT1, BMP1, P3H1, SERPINH1, COL1A1, PPIB, COL1A2, SERPINF1
macromolecule metabolic process (GO:0043170)	0.83	10	SP7, COL1A2, CRTAP, WNT1, FKBP10, BMP1, SERPINH1, COL1A1, PPIB, P3H1
single-organism developmental process (GO:0044767)	1.49	10	IFITM5, SERPINF1, COL1A2, WNT1, BMP1, SERPINH1, COL1A1, PPIB, SPARC, P3H1
organic substance metabolic process (GO:0071704)	0.63	10	SP7, COL1A2, CRTAP, WNT1, FKBP10, BMP1, SERPINH1, COL1A1, PPIB, P3H1
single-organism cellular process (GO:0044763)	0.65	10	SP7, SPARC, CRTAP, WNT1, SERPINF1, SERPINH1, TMEM38B, COL1A1, COL1A2, BMP1
metabolic process (GO:0008152)	0.58	10	SP7, COL1A2, CRTAP, WNT1, FKBP10, BMP1, SERPINH1, COL1A1, PPIB, P3H1
multicellular organismal process (GO:0032501)	1.45	9	IFITM5, SERPINF1, COL1A2, WNT1, BMP1, SERPINH1, COL1A1, SPARC, P3H1
regulation of metabolic process (GO:0019222)	1.02	9	SP7, CRTAP, WNT1, BMP1, SERPINF1, SERPINH1, COL1A1, PPIB, P3H1
single-multicellular organism process (GO:0044707)	1.78	9	IFITM5, SERPINF1, COL1A2, WNT1, BMP1, SERPINH1, COL1A1, SPARC, P3H1
regulation of macromolecule metabolic process (GO:0060255)	1.08	9	SP7, CRTAP, WNT1, BMP1, SERPINF1, SERPINH1, COL1A1, PPIB, P3H1
regulation of cellular metabolic process (GO:0031323)	1.07	9	SP7, CRTAP, WNT1, BMP1, SERPINF1, SERPINH1, COL1A1, PPIB, P3H1
regulation of primary metabolic process (GO:0080090)	1.08	9	SP7, CRTAP, WNT1, BMP1, SERPINF1, SERPINH1, COL1A1, PPIB, P3H1
primary metabolic process (GO:0044238)	0.69	8	SP7, CRTAP, WNT1, FKBP10, BMP1, SERPINH1, PPIB, P3H1
regulation of cellular protein metabolic process (GO:0032268)	1.99	7	SERPINF1, CRTAP, WNT1, BMP1, P3H1, SERPINH1, PPIB
protein metabolic process (GO:0019538)	1.45	7	CRTAP, WNT1, FKBP10, BMP1, P3H1, SERPINH1, PPIB
response to stimulus (GO:0050896)	1.22	7	IFITM5, COL1A2, WNT1, SERPINH1, COL1A1, SPARC, SERPINF1
regulation of protein metabolic process (GO:0051246)	1.93	7	SERPINF1, CRTAP, WNT1, BMP1, P3H1, SERPINH1, PPIB
regulation of developmental process (GO:0050793)	2.1	7	IFITM5, SPARC, WNT1, BMP1, COL1A1, PPIB, SERPINF1
animal organ development (GO:0048513)	2.53	7	SPARC, WNT1, BMP1, P3H1, COL1A1, PPIB, SERPINF1
regulation of multicellular organismal process (GO:0051239)	1.87	7	IFITM5, SPARC, WNT1, BMP1, COL1A1, PPIB, SERPINF1
positive regulation of biological process (GO:0048518)	1.2	7	SP7, SPARC, WNT1, BMP1, COL1A1, PPIB, SERPINF1
negative regulation of biological process (GO:0048519)	1.33	7	SPARC, CRTAP, WNT1, SERPINF1, SERPINH1, COL1A1, P3H1
negative regulation of cellular process (GO:0048523)	1.41	7	SPARC, CRTAP, WNT1, SERPINF1, SERPINH1, COL1A1, P3H1
positive regulation of cellular process (GO:0048522)	1.3	7	SP7, SPARC, WNT1, BMP1, COL1A1, PPIB, SERPINF1
cellular macromolecule metabolic process (GO:0044260)	0.93	6	SP7, CRTAP, WNT1, FKBP10, P3H1, PPIB
positive regulation of multicellular organismal process (GO:0051240)	2.49	6	SPARC, WNT1, BMP1, PPIB, COL1A1, SERPINF1
cellular metabolic process (GO:0044237)	0.69	6	SP7, CRTAP, WNT1, FKBP10, P3H1, PPIB
regulation of multicellular organismal development (GO:2000026)	2.31	6	IFITM5, SPARC, WNT1, BMP1, COL1A1, SERPINF1
cellular component organization (GO:0016043)	1.24	6	COL1A2, WNT1, SERPINH1, COL1A1, SPARC, BMP1
response to chemical (GO:0042221)	1.98	6	SPARC, WNT1, SERPINH1, COL1A1, COL1A2, SERPINF1
regulation of biological quality (GO:0065008)	1.68	6	SERPINF1, COL1A2, CRTAP, P3H1, COL1A1, PPIB
response to organic substance (GO:0010033)	2.2	6	COL1A2, WNT1, SERPINH1, COL1A1, SPARC, SERPINF1
cellular component organization or biogenesis (GO:0071840)	1.22	6	COL1A2, WNT1, SERPINH1, COL1A1, SPARC, BMP1
response to oxygen-containing compound (GO:1901700)	2.57	5	COL1A2, COL1A1, WNT1, SERPINF1, SPARC
response to endogenous stimulus (GO:0009719)	2.79	5	WNT1, COL1A1, COL1A2, SERPINF1, SPARC
cellular response to stimulus (GO:0051716)	1.97	5	SPARC, WNT1, COL1A1, COL1A2, SERPINF1
negative regulation of cellular metabolic process (GO:0031324)	2.01	5	CRTAP, WNT1, P3H1, SERPINH1, SERPINF1
negative regulation of metabolic process (GO:0009892)	1.93	5	CRTAP, WNT1, P3H1, SERPINH1, SERPINF1
negative regulation of cellular protein metabolic process (GO:0032269)	2.88	5	CRTAP, WNT1, P3H1, SERPINF1, SERPINH1
cellular developmental process (GO:0048869)	1.82	5	SP7, COL1A1, BMP1, WNT1, SERPINH1
regulation of protein modification process (GO:0031399)	2.32	5	CRTAP, WNT1, P3H1, PPIB, BMP1
regulation of response to stimulus (GO:0048583)	1.54	5	COL1A2, BMP1, COL1A1, WNT1, SERPINF1
single-organism metabolic process (GO:0044710)	1.63	5	CRTAP, COL1A1, P3H1, COL1A2, SERPINH1
cellular response to organic substance (GO:0071310)	2.78	5	SPARC, WNT1, COL1A1, COL1A2, SERPINF1
extracellular matrix organization (GO:0030198)	4.01	5	COL1A2, BMP1, COL1A1, SPARC, SERPINH1
cellular response to chemical stimulus (GO:0070887)	2.57	5	WNT1, COL1A1, COL1A2, SERPINF1, SPARC
extracellular structure organization (GO:0043062)	4.0	5	SPARC, BMP1, COL1A1, COL1A2, SERPINH1
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	5	CRTAP, WNT1, P3H1, SERPINF1, SERPINH1
negative regulation of protein metabolic process (GO:0051248)	2.82	5	CRTAP, WNT1, P3H1, SERPINH1, SERPINF1
regulation of gene expression (GO:0010468)	1.37	5	SP7, WNT1, COL1A1, BMP1, SERPINF1
positive regulation of developmental process (GO:0051094)	2.77	5	WNT1, BMP1, COL1A1, PPIB, SERPINF1
cellular response to endogenous stimulus (GO:0071495)	3.33	4	COL1A2, COL1A1, WNT1, SERPINF1
protein folding (GO:0006457)	4.32	4	FKBP10, CRTAP, P3H1, PPIB
positive regulation of metabolic process (GO:0009893)	1.74	4	SP7, WNT1, COL1A1, BMP1
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	4	WNT1, COL1A1, SPARC, SERPINF1
macromolecular complex subunit organization (GO:0043933)	2.14	4	WNT1, COL1A1, COL1A2, SERPINH1
regulation of cellular biosynthetic process (GO:0031326)	1.38	4	SP7, WNT1, COL1A1, BMP1
positive regulation of cellular metabolic process (GO:0031325)	1.81	4	SP7, WNT1, COL1A1, BMP1
cell differentiation (GO:0030154)	2.14	4	SP7, WNT1, COL1A1, BMP1
regulation of cellular component organization (GO:0051128)	2.01	4	SPARC, COL1A1, WNT1, SERPINF1
signal transduction (GO:0007165)	1.28	4	WNT1, COL1A2, BMP1, SPARC
collagen metabolic process (GO:0032963)	5.42	4	COL1A2, COL1A1, P3H1, SERPINH1
anatomical structure morphogenesis (GO:0009653)	2.53	4	IFITM5, WNT1, COL1A1, COL1A2
regulation of cell differentiation (GO:0045595)	2.42	4	SP7, WNT1, COL1A1, SERPINF1
multicellular organism development (GO:0007275)	2.54	4	WNT1, BMP1, IFITM5, SERPINF1
cellular protein metabolic process (GO:0044267)	1.63	4	FKBP10, CRTAP, P3H1, PPIB
regulation of localization (GO:0032879)	1.94	4	SPARC, COL1A1, P3H1, SERPINF1
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	4	SP7, WNT1, COL1A1, BMP1
protein complex subunit organization (GO:0071822)	2.6	4	COL1A2, COL1A1, WNT1, SERPINH1
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	4	SP7, WNT1, COL1A1, BMP1
peptidyl-amino acid modification (GO:0018193)	2.98	4	FKBP10, CRTAP, PPIB, P3H1
response to acid chemical (GO:0001101)	4.05	4	COL1A2, COL1A1, SPARC, SERPINF1
regulation of cell proliferation (GO:0042127)	2.41	4	WNT1, P3H1, SPARC, SERPINF1
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	4	SP7, WNT1, COL1A1, BMP1
regulation of biosynthetic process (GO:0009889)	1.37	4	SP7, WNT1, COL1A1, BMP1
cellular protein modification process (GO:0006464)	1.79	4	FKBP10, CRTAP, PPIB, P3H1
macromolecule modification (GO:0043412)	1.73	4	FKBP10, CRTAP, PPIB, P3H1
protein modification process (GO:0036211)	1.79	4	FKBP10, CRTAP, P3H1, PPIB
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	4	SP7, WNT1, COL1A1, BMP1
multicellular organismal macromolecule metabolic process (GO:0044259)	5.36	4	COL1A2, COL1A1, P3H1, SERPINH1
regulation of RNA biosynthetic process (GO:2001141)	1.55	4	SP7, WNT1, COL1A1, BMP1
bone development (GO:0060348)	5.82	4	WNT1, PPIB, SPARC, P3H1
chaperone-mediated protein folding (GO:0061077)	5.84	4	FKBP10, CRTAP, P3H1, PPIB
cellular response to oxygen-containing compound (GO:1901701)	3.22	4	COL1A2, COL1A1, WNT1, SERPINF1
peptidyl-proline modification (GO:0018208)	5.6	4	FKBP10, CRTAP, P3H1, PPIB
response to hormone (GO:0009725)	3.33	4	WNT1, COL1A1, SPARC, SERPINF1
response to organonitrogen compound (GO:0010243)	3.2	4	SPARC, WNT1, COL1A1, COL1A2
regulation of RNA metabolic process (GO:0051252)	1.52	4	SP7, WNT1, COL1A1, BMP1
response to stress (GO:0006950)	1.8	4	WNT1, COL1A1, SPARC, SERPINH1
multicellular organism metabolic process (GO:0044236)	5.2	4	COL1A2, COL1A1, P3H1, SERPINH1
regulation of transcription, DNA-templated (GO:0006355)	1.56	4	SP7, WNT1, COL1A1, BMP1
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	4	SP7, WNT1, COL1A1, BMP1
response to nitrogen compound (GO:1901698)	3.12	4	SPARC, WNT1, COL1A1, COL1A2
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	4	SP7, WNT1, COL1A1, BMP1
regulation of post-translational protein modification (GO:1901873)	8.63	3	CRTAP, P3H1, PPIB
cellular response to nitrogen compound (GO:1901699)	3.79	3	WNT1, COL1A1, COL1A2
positive regulation of biosynthetic process (GO:0009891)	2.29	3	SP7, WNT1, COL1A1
positive regulation of response to stimulus (GO:0048584)	2.18	3	WNT1, COL1A1, BMP1
cell development (GO:0048468)	3.28	3	WNT1, BMP1, SERPINH1
cellular response to acid chemical (GO:0071229)	4.67	3	COL1A2, COL1A1, SERPINF1
protein stabilization (GO:0050821)	4.86	3	CRTAP, P3H1, PPIB
skeletal system development (GO:0001501)	4.49	3	COL1A2, COL1A1, BMP1
ossification (GO:0001503)	4.86	3	SPARC, COL1A1, BMP1
cell surface receptor signaling pathway (GO:0007166)	2.09	3	WNT1, COL1A2, BMP1
regulation of signaling (GO:0023051)	1.72	3	WNT1, COL1A1, BMP1
positive regulation of cell communication (GO:0010647)	2.41	3	WNT1, COL1A1, BMP1
regulation of cell communication (GO:0010646)	1.73	3	WNT1, COL1A1, BMP1
response to organic cyclic compound (GO:0014070)	3.07	3	SPARC, COL1A1, SERPINF1
immune system process (GO:0002376)	2.29	3	WNT1, COL1A1, COL1A2
response to inorganic substance (GO:0010035)	3.56	3	SPARC, COL1A1, SERPINF1
regulation of signal transduction (GO:0009966)	1.84	3	WNT1, COL1A1, BMP1
positive regulation of signal transduction (GO:0009967)	2.5	3	WNT1, COL1A1, BMP1
cellular response to organonitrogen compound (GO:0071417)	3.87	3	WNT1, COL1A1, COL1A2
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	3	SP7, WNT1, COL1A1
response to wounding (GO:0009611)	4.39	3	SPARC, COL1A1, WNT1
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	3	SP7, WNT1, COL1A1
negative regulation of developmental process (GO:0051093)	3.17	3	WNT1, SPARC, SERPINF1
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	3	SP7, WNT1, BMP1
response to peptide (GO:1901652)	3.94	3	SPARC, COL1A1, WNT1
regulation of molecular function (GO:0065009)	1.78	3	WNT1, SERPINH1, SERPINF1
positive regulation of cellular component organization (GO:0051130)	2.68	3	WNT1, COL1A1, SERPINF1
negative regulation of cell proliferation (GO:0008285)	3.26	3	SPARC, P3H1, SERPINF1
organ morphogenesis (GO:0009887)	3.55	3	COL1A2, COL1A1, IFITM5
regulation of cell migration (GO:0030334)	3.23	3	SPARC, COL1A1, SERPINF1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	3	SP7, WNT1, COL1A1
organic substance biosynthetic process (GO:1901576)	1.34	3	SP7, COL1A1, SERPINH1
response to corticosteroid (GO:0031960)	4.56	3	SPARC, COL1A1, SERPINF1
transport (GO:0006810)	1.51	3	TMEM38B, SPARC, COL1A1
biosynthetic process (GO:0009058)	1.32	3	SP7, COL1A1, SERPINH1
cell activation (GO:0001775)	3.47	3	WNT1, COL1A1, COL1A2
regulation of locomotion (GO:0040012)	3.12	3	SPARC, COL1A1, SERPINF1
regulation of proteolysis (GO:0030162)	3.2	3	WNT1, SERPINH1, SERPINF1
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	3	SP7, WNT1, COL1A1
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	3	SP7, WNT1, COL1A1
response to peptide hormone (GO:0043434)	4.06	3	WNT1, COL1A1, SPARC
establishment of localization (GO:0051234)	1.48	3	TMEM38B, SPARC, COL1A1
catabolic process (GO:0009056)	2.38	3	WNT1, COL1A1, COL1A2
localization (GO:0051179)	1.4	3	TMEM38B, SPARC, COL1A1
positive regulation of signaling (GO:0023056)	2.41	3	WNT1, COL1A1, BMP1
positive regulation of cell differentiation (GO:0045597)	3.01	3	SP7, COL1A1, SERPINF1
response to abiotic stimulus (GO:0009628)	2.8	3	SPARC, COL1A1, SERPINF1
regulation of cellular component movement (GO:0051270)	3.08	3	SPARC, COL1A1, SERPINF1
negative regulation of protein modification process (GO:0031400)	3.4	3	WNT1, CRTAP, P3H1
regulation of protein stability (GO:0031647)	4.33	3	CRTAP, P3H1, PPIB
positive regulation of RNA metabolic process (GO:0051254)	2.51	3	SP7, WNT1, COL1A1
macromolecule biosynthetic process (GO:0009059)	1.61	3	SP7, COL1A1, SERPINH1
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	3	SP7, WNT1, COL1A1
collagen fibril organization (GO:0030199)	6.07	3	COL1A2, COL1A1, SERPINH1
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	3	SP7, WNT1, COL1A1
positive regulation of gene expression (GO:0010628)	2.35	3	SP7, WNT1, COL1A1
regulation of cell motility (GO:2000145)	3.16	3	SPARC, COL1A1, SERPINF1
response to lipid (GO:0033993)	3.11	3	SPARC, COL1A1, SERPINF1
system development (GO:0048731)	2.92	3	COL1A2, COL1A1, BMP1
negative regulation of proteolysis (GO:0045861)	3.98	3	WNT1, SERPINH1, SERPINF1
response to steroid hormone (GO:0048545)	4.24	3	SPARC, COL1A1, SERPINF1
hemostasis (GO:0007599)	4.5	2	COL1A2, COL1A1
negative regulation of response to stimulus (GO:0048585)	2.52	2	WNT1, SERPINF1
blood coagulation (GO:0007596)	4.52	2	COL1A2, COL1A1
negative regulation of epithelial cell proliferation (GO:0050680)	4.98	2	SPARC, SERPINF1
negative regulation of cell adhesion (GO:0007162)	4.33	2	WNT1, COL1A1
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	2	COL1A2, BMP1
regulation of phosphate metabolic process (GO:0019220)	2.35	2	WNT1, BMP1
regulation of cell projection organization (GO:0031344)	3.38	2	WNT1, SERPINF1
positive regulation of cell projection organization (GO:0031346)	3.99	2	WNT1, SERPINF1
single-organism catabolic process (GO:0044712)	3.21	2	COL1A2, COL1A1
response to amino acid (GO:0043200)	5.12	2	COL1A2, COL1A1
single-organism biosynthetic process (GO:0044711)	2.8	2	COL1A1, SERPINH1
response to growth factor (GO:0070848)	4.14	2	SPARC, COL1A1
positive regulation of cell development (GO:0010720)	3.57	2	COL1A1, SERPINF1
negative regulation of molecular function (GO:0044092)	2.74	2	SERPINF1, SERPINH1
transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0007178)	4.6	2	COL1A2, BMP1
protein heterooligomerization (GO:0051291)	5.22	2	COL1A2, COL1A1
response to cAMP (GO:0051591)	5.08	2	SPARC, COL1A1
response to metal ion (GO:0010038)	3.91	2	SPARC, SERPINF1
cellular response to growth factor stimulus (GO:0071363)	4.27	2	SPARC, COL1A1
platelet activation (GO:0030168)	4.96	2	COL1A2, COL1A1
system process (GO:0003008)	2.3	2	COL1A1, SERPINF1
regulation of phosphorylation (GO:0042325)	2.5	2	WNT1, BMP1
positive regulation of phosphorylation (GO:0042327)	2.9	2	WNT1, BMP1
single organism reproductive process (GO:0044702)	2.73	2	CRTAP, SERPINF1
response to biotic stimulus (GO:0009607)	3.09	2	SPARC, IFITM5
response to external stimulus (GO:0009605)	2.55	2	SPARC, COL1A1
regulation of epithelial cell migration (GO:0010632)	4.62	2	SPARC, SERPINF1
response to monosaccharide (GO:0034284)	4.77	2	SPARC, SERPINF1
cell motility (GO:0048870)	3.02	2	COL1A2, COL1A1
response to nutrient levels (GO:0031667)	3.77	2	SPARC, COL1A1
regulation of canonical Wnt signaling pathway (GO:0060828)	4.26	2	WNT1, COL1A1
regulation of cell morphogenesis (GO:0022604)	3.4	2	SPARC, COL1A1
regulation of Wnt signaling pathway (GO:0030111)	3.98	2	WNT1, COL1A1
cellular component assembly (GO:0022607)	2.14	2	COL1A2, COL1A1
negative regulation of post-translational protein modification (GO:1901874)	9.04	2	CRTAP, P3H1
positive regulation of canonical Wnt signaling pathway (GO:0090263)	4.95	2	WNT1, COL1A1
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092)	4.39	2	WNT1, BMP1
movement of cell or subcellular component (GO:0006928)	2.61	2	COL1A2, COL1A1
regulation of vasculature development (GO:1901342)	4.26	2	SPARC, SERPINF1
negative regulation of vasculature development (GO:1901343)	5.32	2	SPARC, SERPINF1
intracellular signal transduction (GO:0035556)	2.39	2	WNT1, COL1A2
protein trimerization (GO:0070206)	6.04	2	COL1A2, COL1A1
negative regulation of hydrolase activity (GO:0051346)	3.74	2	SERPINF1, SERPINH1
blood vessel development (GO:0001568)	4.95	2	COL1A2, COL1A1
macromolecular complex assembly (GO:0065003)	2.55	2	COL1A2, COL1A1
regulation of cell-substrate adhesion (GO:0010810)	4.56	2	WNT1, COL1A1
regulation of immune system process (GO:0002682)	2.5	2	COL1A2, COL1A1
cell migration (GO:0016477)	3.12	2	COL1A2, COL1A1
negative regulation of cell-substrate adhesion (GO:0010812)	5.76	2	WNT1, COL1A1
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	2	WNT1, COL1A1
protein heterotrimerization (GO:0070208)	7.09	2	COL1A2, COL1A1
response to cytokine (GO:0034097)	3.84	2	SPARC, COL1A1
regulation of catalytic activity (GO:0050790)	1.97	2	SERPINF1, SERPINH1
tissue development (GO:0009888)	3.27	2	IFITM5, COL1A1
wound healing (GO:0042060)	5.13	2	SPARC, COL1A1
coagulation (GO:0050817)	4.51	2	COL1A2, COL1A1
regulation of hydrolase activity (GO:0051336)	2.53	2	SERPINF1, SERPINH1
positive regulation of protein modification process (GO:0031401)	2.7	2	WNT1, BMP1
collagen catabolic process (GO:0030574)	5.57	2	COL1A2, COL1A1
protein hydroxylation (GO:0018126)	6.84	2	CRTAP, P3H1
positive regulation of cell motility (GO:2000147)	3.74	2	SPARC, COL1A1
regulation of cell adhesion (GO:0030155)	3.27	2	WNT1, COL1A1
collagen biosynthetic process (GO:0032964)	7.94	2	COL1A1, SERPINH1
cell adhesion (GO:0007155)	2.82	2	WNT1, COL1A1
response to purine-containing compound (GO:0014074)	4.67	2	SPARC, COL1A1
multicellular organism catabolic process (GO:0044243)	5.47	2	COL1A2, COL1A1
negative regulation of catalytic activity (GO:0043086)	3.0	2	SERPINF1, SERPINH1
protein peptidyl-prolyl isomerization (GO:0000413)	5.86	2	FKBP10, PPIB
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	2	WNT1, BMP1
negative regulation of multicellular organismal process (GO:0051241)	2.84	2	SPARC, SERPINF1
positive regulation of protein metabolic process (GO:0051247)	2.43	2	WNT1, BMP1
regulation of cell development (GO:0060284)	3.01	2	COL1A1, SERPINF1
response to vitamin (GO:0033273)	5.11	2	SPARC, COL1A1
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	2	WNT1, BMP1
biological adhesion (GO:0022610)	2.81	2	WNT1, COL1A1
multicellular organismal reproductive process (GO:0048609)	3.35	2	CRTAP, SERPINF1
regulation of body fluid levels (GO:0050878)	3.76	2	COL1A2, COL1A1
cell proliferation (GO:0008283)	3.23	2	WNT1, SERPINF1
neurological system process (GO:0050877)	2.64	2	COL1A1, SERPINF1
cellular response to lipid (GO:0071396)	3.96	2	COL1A1, SERPINF1
cellular response to hormone stimulus (GO:0032870)	3.99	2	WNT1, SERPINF1
proteolysis (GO:0006508)	2.73	2	WNT1, BMP1
response to carbohydrate (GO:0009743)	4.62	2	SPARC, SERPINF1
protein oligomerization (GO:0051259)	3.71	2	COL1A2, COL1A1
regulation of immune response (GO:0050776)	2.98	2	COL1A2, COL1A1
regulation of epithelial cell proliferation (GO:0050678)	4.06	2	SPARC, SERPINF1
cellular response to organic cyclic compound (GO:0071407)	3.93	2	COL1A1, SERPINF1
positive regulation of Wnt signaling pathway (GO:0030177)	4.7	2	WNT1, COL1A1
nitrogen compound metabolic process (GO:0006807)	1.13	2	SP7, CRTAP
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	2	SP7, WNT1
negative regulation of angiogenesis (GO:0016525)	5.42	2	SPARC, SERPINF1
response to extracellular stimulus (GO:0009991)	3.71	2	SPARC, COL1A1
response to glucocorticoid (GO:0051384)	4.63	2	SPARC, SERPINF1
negative regulation of blood vessel morphogenesis (GO:2000181)	5.38	2	SPARC, SERPINF1
leukocyte migration (GO:0050900)	4.19	2	COL1A2, COL1A1
regulation of cell death (GO:0010941)	2.43	2	BMP1, SERPINF1
osteoblast differentiation (GO:0001649)	5.05	2	SP7, COL1A1
regulation of angiogenesis (GO:0045765)	4.36	2	SPARC, SERPINF1
positive regulation of cell migration (GO:0030335)	3.77	2	SPARC, COL1A1
negative regulation of peptidase activity (GO:0010466)	4.22	2	SERPINF1, SERPINH1
response to organophosphorus (GO:0046683)	4.79	2	SPARC, COL1A1
skin morphogenesis (GO:0043589)	7.53	2	COL1A2, COL1A1
response to retinoic acid (GO:0032526)	5.02	2	COL1A1, SERPINF1
cellular response to amino acid stimulus (GO:0071230)	5.7	2	COL1A2, COL1A1
positive regulation of phosphate metabolic process (GO:0045937)	2.78	2	WNT1, BMP1
regulation of peptidase activity (GO:0052547)	3.75	2	SERPINF1, SERPINH1
regulation of endopeptidase activity (GO:0052548)	3.8	2	SERPINF1, SERPINH1
response to nutrient (GO:0007584)	4.49	2	SPARC, COL1A1
protein complex assembly (GO:0006461)	2.78	2	COL1A2, COL1A1
regulation of phosphorus metabolic process (GO:0051174)	2.35	2	WNT1, BMP1
reproductive process (GO:0022414)	2.55	2	CRTAP, SERPINF1
single-organism transport (GO:0044765)	2.18	2	TMEM38B, SPARC
cartilage development (GO:0051216)	5.31	2	COL1A1, BMP1
cellular component disassembly (GO:0022411)	3.52	2	WNT1, BMP1
biomineral tissue development (GO:0031214)	5.41	2	IFITM5, COL1A1
negative regulation of endopeptidase activity (GO:0010951)	4.26	2	SERPINF1, SERPINH1
cell communication (GO:0007154)	3.04	2	WNT1, COL1A1
single-organism localization (GO:1902578)	2.09	2	TMEM38B, SPARC
locomotion (GO:0040011)	2.91	2	COL1A2, COL1A1
positive regulation of cellular component movement (GO:0051272)	3.71	2	SPARC, COL1A1
regulation of endothelial cell migration (GO:0010594)	4.99	2	SPARC, SERPINF1
positive regulation of locomotion (GO:0040017)	3.71	2	SPARC, COL1A1
peptidyl-proline hydroxylation (GO:0019511)	7.16	2	CRTAP, P3H1
cellular response to retinoic acid (GO:0071300)	5.52	2	COL1A1, SERPINF1
regulation of protein phosphorylation (GO:0001932)	2.57	2	WNT1, BMP1
positive regulation of protein phosphorylation (GO:0001934)	2.95	2	WNT1, BMP1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
regulation of post-translational protein modification (GO:1901873)	-	8.63	0.0	CRTAP, P3H1
protein folding (GO:0006457)	-	4.32	0.013	CRTAP, FKBP10, P3H1, COL1A2, PPIB
multicellular organismal macromolecule metabolic process (GO:0044259)	-	5.36	0.0	COL1A2, COL1A1, P3H1, SERPINH1
negative regulation of post-translational protein modification (GO:1901874)	-	9.04	0.0	CRTAP, P3H1
bone development (GO:0060348)	-	5.82	0.0	SPARC, WNT1, P3H1, COL1A1, COL1A2, PPIB
collagen biosynthetic process (GO:0032964)	-	7.94	0.024	COL1A1, SERPINH1
skeletal system development (GO:0001501)	-	4.49	0.003	SP7, COL1A2, WNT1, COL1A1, SPARC, BMP1
ossification (GO:0001503)	-	4.86	0.049	SPARC, COL1A1, BMP1
collagen metabolic process (GO:0032963)	-	5.42	0.008	COL1A2, COL1A1, P3H1, SERPINH1
peptidyl-proline hydroxylation (GO:0019511)	-	7.16	0.022	CRTAP, P3H1, PPIB
negative regulation of peptidase activity (GO:0010466)	-	4.22	0.009	COL1A2, WNT1, BMP1, SERPINH1, COL1A1, SERPINF1
extracellular structure organization (GO:0043062)	-	4.0	0.0	SPARC, CRTAP, BMP1, SERPINH1, COL1A1, PPIB, COL1A2, P3H1
extracellular matrix disassembly (GO:0022617)	NEW	5.38	0.044	COL1A2, BMP1, COL1A1, SPARC, SERPINH1
skin morphogenesis (GO:0043589)	-	7.53	0.01	COL1A2, COL1A1
developmental process (GO:0032502)	-	1.36	0.017	SP7, IFITM5, P3H1, SPARC, WNT1, BMP1, SERPINH1, COL1A1, PPIB, COL1A2, SERPINF1
negative regulation of cell proliferation (GO:0008285)	-	3.26	0.004	SP7, SPARC, WNT1, BMP1, P3H1, SERPINH1, COL1A1, COL1A2, SERPINF1
response to nutrient (GO:0007584)	-	4.49	0.041	SP7, SPARC, BMP1, COL1A1, PPIB
protein heterotrimerization (GO:0070208)	-	7.09	0.019	COL1A2, COL1A1
response to acid chemical (GO:0001101)	-	4.05	0.025	COL1A2, COL1A1, SPARC, SERPINF1
regulation of multicellular organismal process (GO:0051239)	-	1.87	0.027	IFITM5, SPARC, WNT1, BMP1, P3H1, COL1A1, PPIB, SERPINF1
biomineral tissue development (GO:0031214)	-	5.41	0.024	SPARC, COL1A1, IFITM5, SERPINH1
negative regulation of endopeptidase activity (GO:0010951)	-	4.26	0.007	COL1A2, WNT1, BMP1, SERPINH1, COL1A1, SERPINF1
regulation of ossification (GO:0030278)	NEW	4.53	0.002	SP7, IFITM5, COL1A2, BMP1, SERPINH1, P3H1
chaperone-mediated protein folding (GO:0061077)	-	5.84	0.0	FKBP10, CRTAP, P3H1, PPIB
negative regulation of developmental process (GO:0051093)	-	3.17	0.012	SP7, COL1A2, WNT1, SERPINF1, SERPINH1, COL1A1, PPIB, SPARC, BMP1
protein stabilization (GO:0050821)	-	4.86	0.021	CRTAP, P3H1, PPIB
peptidyl-proline modification (GO:0018208)	-	5.6	0.0	COL1A1, PPIB, CRTAP, FKBP10, P3H1
anatomical structure development (GO:0048856)	-	1.58	0.001	IFITM5, SERPINF1, COL1A2, WNT1, BMP1, SERPINH1, COL1A1, PPIB, SPARC, P3H1
multicellular organismal metabolic process (GO:0044236)	-	5.2	0.02	COL1A2, COL1A1, P3H1, SERPINH1
collagen fibril organization (GO:0030199)	-	6.07	0.0	SPARC, P3H1, COL1A2, SERPINH1, COL1A1
extracellular matrix organization (GO:0030198)	-	4.01	0.0	SPARC, CRTAP, BMP1, SERPINH1, COL1A1, PPIB, COL1A2, P3H1
protein hydroxylation (GO:0018126)	-	6.84	0.035	CRTAP, P3H1, PPIB
negative regulation of angiogenesis (GO:0016525)	-	5.42	0.022	COL1A2, COL1A1, SPARC, SERPINF1

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	14	SP7, IFITM5, SERPINF1, SPARC, CRTAP, FKBP10, WNT1, P3H1, SERPINH1, TMEM38B, COL1A1, PPIB, COL1A2, BMP1
intracellular part (GO:0044424)	0.28	13	SP7, P3H1, SPARC, CRTAP, WNT1, FKBP10, SERPINF1, SERPINH1, TMEM38B, COL1A1, PPIB, COL1A2, BMP1
membrane-bounded organelle (GO:0043227)	0.47	13	SP7, P3H1, SPARC, CRTAP, WNT1, FKBP10, SERPINF1, SERPINH1, TMEM38B, COL1A1, PPIB, COL1A2, BMP1
organelle (GO:0043226)	0.4	13	SP7, P3H1, SPARC, CRTAP, WNT1, FKBP10, SERPINF1, SERPINH1, TMEM38B, COL1A1, PPIB, COL1A2, BMP1
cytoplasmic part (GO:0044444)	0.82	12	P3H1, SPARC, CRTAP, WNT1, FKBP10, BMP1, SERPINH1, TMEM38B, COL1A1, PPIB, COL1A2, SERPINF1
intracellular organelle (GO:0043229)	0.51	11	SP7, P3H1, SPARC, CRTAP, FKBP10, SERPINF1, SERPINH1, TMEM38B, COL1A1, PPIB, BMP1
intracellular membrane-bounded organelle (GO:0043231)	0.6	11	SP7, P3H1, SPARC, CRTAP, FKBP10, SERPINF1, SERPINH1, TMEM38B, COL1A1, PPIB, BMP1
intracellular organelle part (GO:0044446)	0.81	10	COL1A2, CRTAP, WNT1, FKBP10, PPIB, SERPINH1, TMEM38B, COL1A1, SPARC, P3H1
extracellular region part (GO:0044421)	1.57	10	SPARC, CRTAP, WNT1, BMP1, P3H1, SERPINH1, COL1A1, PPIB, COL1A2, SERPINF1
organelle part (GO:0044422)	0.79	10	COL1A2, CRTAP, WNT1, FKBP10, PPIB, SERPINH1, TMEM38B, COL1A1, SPARC, P3H1
vesicle (GO:0031982)	1.64	9	SERPINF1, COL1A2, WNT1, BMP1, SERPINH1, COL1A1, PPIB, SPARC, P3H1
organelle lumen (GO:0043233)	3.05	9	COL1A2, CRTAP, WNT1, FKBP10, PPIB, SERPINH1, COL1A1, SPARC, P3H1
membrane (GO:0016020)	0.68	9	IFITM5, SPARC, FKBP10, WNT1, PPIB, SERPINH1, TMEM38B, COL1A1, P3H1
membrane-enclosed lumen (GO:0031974)	3.05	9	COL1A2, CRTAP, WNT1, FKBP10, PPIB, SERPINH1, COL1A1, SPARC, P3H1
membrane-bounded vesicle (GO:0031988)	1.71	9	SPARC, WNT1, BMP1, P3H1, SERPINH1, COL1A1, PPIB, COL1A2, SERPINF1
endoplasmic reticulum part (GO:0044432)	2.73	9	COL1A2, CRTAP, WNT1, FKBP10, PPIB, SERPINH1, TMEM38B, COL1A1, P3H1
intracellular organelle lumen (GO:0070013)	3.05	9	COL1A2, CRTAP, WNT1, FKBP10, PPIB, SERPINH1, COL1A1, SPARC, P3H1
extracellular region (GO:0005576)	2.18	8	SERPINF1, COL1A2, CRTAP, WNT1, BMP1, COL1A1, SPARC, P3H1
extracellular space (GO:0005615)	2.63	8	COL1A2, CRTAP, WNT1, BMP1, SERPINH1, COL1A1, SPARC, SERPINF1
endoplasmic reticulum lumen (GO:0005788)	4.5	8	COL1A2, CRTAP, WNT1, FKBP10, PPIB, SERPINH1, COL1A1, P3H1
extracellular matrix (GO:0031012)	3.81	8	SPARC, CRTAP, WNT1, BMP1, P3H1, COL1A1, COL1A2, SERPINF1
endoplasmic reticulum (GO:0005783)	2.56	7	CRTAP, FKBP10, P3H1, SERPINH1, TMEM38B, COL1A1, PPIB
proteinaceous extracellular matrix (GO:0005578)	4.01	7	COL1A2, CRTAP, WNT1, BMP1, COL1A1, SPARC, P3H1
macromolecular complex (GO:0032991)	1.35	6	COL1A2, CRTAP, P3H1, SERPINH1, COL1A1, PPIB
extracellular vesicle (GO:1903561)	1.89	6	SERPINF1, COL1A2, WNT1, P3H1, SERPINH1, PPIB
extracellular organelle (GO:0043230)	1.89	6	SERPINF1, COL1A2, WNT1, P3H1, SERPINH1, PPIB
extracellular exosome (GO:0070062)	1.89	6	P3H1, COL1A2, WNT1, PPIB, SERPINH1, SERPINF1
cytoplasm (GO:0005737)	1.01	5	SP7, COL1A1, WNT1, SERPINH1, SPARC
membrane part (GO:0044425)	0.95	5	TMEM38B, FKBP10, COL1A1, IFITM5, SERPINH1
protein complex (GO:0043234)	1.51	4	COL1A2, COL1A1, PPIB, SERPINH1
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	4	SPARC, COL1A1, PPIB, SERPINF1
cytoplasmic vesicle (GO:0031410)	2.87	4	SPARC, COL1A1, PPIB, SERPINF1
nucleus (GO:0005634)	1.07	4	TMEM38B, SP7, SPARC, PPIB
intracellular vesicle (GO:0097708)	2.86	4	SPARC, COL1A1, PPIB, SERPINF1
extracellular matrix component (GO:0044420)	4.97	4	COL1A2, COL1A1, SPARC, SERPINF1
collagen trimer (GO:0005581)	5.21	3	COL1A2, COL1A1, SERPINH1
integral component of membrane (GO:0016021)	1.14	3	TMEM38B, IFITM5, COL1A1
plasma membrane (GO:0005886)	1.39	3	IFITM5, WNT1, SPARC
bounding membrane of organelle (GO:0098588)	2.39	3	TMEM38B, WNT1, SPARC
intrinsic component of membrane (GO:0031224)	1.13	3	TMEM38B, IFITM5, COL1A1
organelle membrane (GO:0031090)	1.97	3	TMEM38B, WNT1, SPARC
collagen type I trimer (GO:0005584)	9.11	2	COL1A2, COL1A1
Golgi apparatus (GO:0005794)	2.7	2	COL1A1, BMP1
melanosome (GO:0042470)	5.22	2	PPIB, SERPINF1
secretory vesicle (GO:0099503)	4.0	2	SPARC, COL1A1
fibrillar collagen trimer (GO:0005583)	7.32	2	COL1A2, COL1A1
secretory granule (GO:0030141)	4.34	2	SPARC, COL1A1
cell surface (GO:0009986)	3.44	2	WNT1, SPARC
pigment granule (GO:0048770)	5.22	2	PPIB, SERPINF1
endoplasmic reticulum membrane (GO:0005789)	2.95	2	TMEM38B, FKBP10
cytoplasmic vesicle part (GO:0044433)	3.41	2	SPARC, WNT1
cytoplasmic vesicle membrane (GO:0030659)	3.67	2	SPARC, WNT1
basement membrane (GO:0005604)	5.34	2	SPARC, SERPINF1
nuclear part (GO:0044428)	1.55	2	TMEM38B, SPARC
vesicle membrane (GO:0012506)	3.63	2	WNT1, SPARC
perinuclear region of cytoplasm (GO:0048471)	3.35	2	PPIB, SERPINF1
whole membrane (GO:0098805)	2.85	2	SPARC, WNT1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
collagen type I trimer (GO:0005584)	-	9.11	0.0	COL1A2, COL1A1
extracellular space (GO:0005615)	-	2.63	0.0	SP7, SERPINF1, COL1A2, CRTAP, WNT1, BMP1, SERPINH1, COL1A1, PPIB, SPARC, P3H1
intracellular organelle lumen (GO:0070013)	-	3.05	0.0	COL1A2, CRTAP, WNT1, FKBP10, PPIB, SERPINH1, COL1A1, SPARC, P3H1
extracellular region part (GO:0044421)	-	1.57	0.002	SERPINF1, COL1A2, CRTAP, WNT1, BMP1, SERPINH1, COL1A1, PPIB, SPARC, P3H1
fibrillar collagen trimer (GO:0005583)	-	7.32	0.007	COL1A2, COL1A1
organelle lumen (GO:0043233)	-	3.05	0.0	COL1A2, CRTAP, WNT1, FKBP10, PPIB, SERPINH1, COL1A1, SPARC, P3H1
membrane-enclosed lumen (GO:0031974)	-	3.05	0.0	COL1A2, CRTAP, WNT1, FKBP10, PPIB, SERPINH1, COL1A1, SPARC, P3H1
extracellular matrix (GO:0031012)	-	3.81	0.0	SP7, COL1A2, CRTAP, WNT1, BMP1, SERPINH1, COL1A1, SPARC, P3H1
endoplasmic reticulum part (GO:0044432)	-	2.73	0.0	COL1A2, CRTAP, WNT1, FKBP10, PPIB, SERPINH1, TMEM38B, COL1A1, SPARC, P3H1
cytoplasmic part (GO:0044444)	-	0.82	0.038	P3H1, SPARC, CRTAP, WNT1, FKBP10, BMP1, SERPINH1, TMEM38B, COL1A1, PPIB, COL1A2, SERPINF1
extracellular region (GO:0005576)	-	2.18	0.045	SP7, COL1A2, WNT1, SERPINF1, SERPINH1, COL1A1, PPIB, SPARC, BMP1
endoplasmic reticulum lumen (GO:0005788)	-	4.5	0.0	COL1A2, CRTAP, WNT1, FKBP10, PPIB, SERPINH1, COL1A1, SPARC, P3H1
extracellular matrix part (GO:0044420)	-	4.97	0.013	SPARC, COL1A1, COL1A2, P3H1
proteinaceous extracellular matrix (GO:0005578)	-	4.01	0.0	SP7, COL1A2, CRTAP, WNT1, BMP1, SERPINH1, COL1A1, SPARC, P3H1
collagen trimer (GO:0005581)	-	5.21	0.001	COL1A2, COL1A1, SPARC, SERPINH1