Disease table of CONGENITAL DISORDERS OF GLYCOSYLATION, TYPE II OMIM ID: PS212066

Gene-disease associations table

GeneAssociated with CONGENITAL DISORDERS OF GLYCOSYLATION, TYPE II inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
COG8ClinVar, OMIMHGNC link16q22.11PS212066
COG1ClinVar, OMIMHGNC link17q25.11PS212066
CCDC115ClinVar, OMIM, HUMSAVARHGNC link2q21.11PS212066
COG7ClinVar, OMIMHGNC link16p12.21PS212066
COG6ClinVar, OMIM, HUMSAVARHGNC link13q14.112PS212066, 615328
COG5ClinVar, OMIMHGNC link7q22.31PS212066
COG4ClinVar, OMIM, HUMSAVARHGNC link16q22.11PS212066
SLC39A8ClinVar, OMIMHGNC link4q241PS212066
MGAT2ClinVar, OMIM, HUMSAVARHGNC link14q21.31PS212066
TMEM165ClinVar, OMIM, HUMSAVARHGNC link4q121PS212066
SLC35A1OMIMHGNC link6q151PS212066
SLC35A2ClinVar, OMIM, HUMSAVARHGNC linkXp11.232PS212066, PS308350
B4GALT1OMIMHGNC link9p21.11PS212066
TMEM199ClinVar, OMIM, HUMSAVARHGNC link17q11.21PS212066
MOGSClinVar, OMIM, HUMSAVARHGNC link2p13.11PS212066
SLC35C1ClinVar, OMIM, HUMSAVARHGNC link11p11.21PS212066

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
16q22.12COG4, COG8
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
16q222COG4, COG8
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
16q22COG4, COG8
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
4q2TMEM165, SLC39A8
16q2COG4, COG8
17q2COG1, TMEM199
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
172COG1, TMEM199
163COG7, COG4, COG8
22MOGS, CCDC115
42TMEM165, SLC39A8
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC12B4GALT1, SLC39A8
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
SLC39A8YES1SP10
B4GALT1YES1SP10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
COG8COG1Yes7COG5, COG7, COG2, COG4, BSG, COG6, COG3
COG8COG7Yes9COG5, COG2, COG1, VSIG2, CA14, COG6, BSG, COG4, COG3
COG8COG6Yes7COG5, COG7, COG2, COG1, VSIG2, COG4, COG3
COG8COG5Yes8COG7, COG2, COG1, VSIG2, COG6, BSG, COG4, COG3
COG8COG4Yes9COG5, COG7, COG2, COG1, VSIG2, CA14, COG6, BSG, COG3
COG1COG7Yes10COG5, CD274, COG8, COG4, EGFR, NTRK1, COG6, BSG, COG2, COG3
COG1COG6Yes9SCN2B, COG5, COG7, COG8, PARP16, EGFR, COG4, COG2, COG3
COG1COG5Yes11PARP16, COG7, CD274, COG2, COG4, EGFR, NTRK1, COG6, BSG, COG8, COG3
COG1COG4Yes11SCN2B, COG5, COG7, CD274, COG2, EGFR, NTRK1, COG6, BSG, COG8, COG3
COG1TMEM165No1RAB5C
COG1TMEM199No1RAB5C
COG1MOGSNo1NTRK1
CCDC115TMEM199No8TMEM216, ATP6AP2, GOLT1B, TMEM17, TCTN2, TCTN3, TSPAN17, TMED2
COG7COG6Yes9COG5, COG8, COG1, VSIG2, EGFR, COG4, DTNBP1, COG2, COG3
COG7COG5Yes15NEK9, CD274, COG8, VSIG2, COG1, COG4, POC1B, TRAF5, EGFR, NTRK1, COG6, DTNBP1, BSG, COG2, COG3
COG7COG4Yes12EGFR, COG5, CD274, COG8, COG1, VSIG2, CA14, NTRK1, COG6, BSG, COG2, COG3
COG7MOGSNo1NTRK1
COG6COG5Yes10PARP16, COG7, COG2, COG1, VSIG2, EGFR, COG4, DTNBP1, COG8, COG3
COG6COG4Yes9SCN2B, COG5, COG7, COG2, COG1, VSIG2, EGFR, COG8, COG3
COG5COG4Yes13APC, VCP, COG7, CD274, COG2, COG1, VSIG2, EGFR, NTRK1, COG6, BSG, COG8, COG3
COG5MOGSNo1NTRK1
COG4MOGSNo1NTRK1
TMEM165TMEM199No1RAB5C
TMEM199MOGSNo1EVC2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
COG8COG1Yesbinding7COG5, COG7, COG2, COG4, COG6, COG3, GOLGA3
COG8COG7Yesbinding7COG5, COG2, COG1, COG4, COG6, COG3, GOLGA3
COG8COG6Yesbinding7COG5, COG7, COG2, COG1, COG4, GOLGA3, COG3
COG8COG5Yesbinding7COG7, COG2, COG1, COG4, COG6, COG3, GOLGA3
COG8COG4Yesbinding7COG5, COG7, COG2, COG1, COG6, GOLGA3, COG3
COG1COG7Yesbinding7COG5, COG8, COG2, COG4, COG6, COG3, GOLGA3
COG1COG6Yesbinding7COG5, COG7, COG8, COG4, COG2, COG3, GOLGA3
COG1COG5Yesbinding8COG7, COG8, COG2, UBC, COG4, COG6, COG3, GOLGA3
COG1COG4Yesbinding8COG5, COG7, COG8, UBC, COG6, COG2, COG3, GOLGA3
COG1TMEM165No-1UBC
COG1MOGSNo-1UBC
COG7COG6Yesbinding7COG5, COG8, COG1, COG4, COG2, COG3, GOLGA3
COG7COG5Yesbinding7COG8, COG1, COG6, COG4, COG2, COG3, GOLGA3
COG7COG4Yesbinding8COG5, COG2, COG1, COG6, SCFD1, COG8, COG3, GOLGA3
COG6COG5Yesbinding7COG7, COG8, COG1, COG4, COG2, COG3, GOLGA3
COG6COG4Yesbinding7COG5, COG7, COG8, COG1, GOLGA3, COG2, COG3
COG5COG4Yesbinding8COG7, COG8, COG1, UBC, COG6, COG2, COG3, GOLGA3
COG5TMEM165No-1UBC
COG5MOGSNo-1UBC
COG4TMEM165No-1UBC
COG4MOGSNo-1UBC
TMEM165MOGSNo-1UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
COG8COG1YesConserved oligomeric Golgi (COG) complex;COG1-COG8 subcomplex;COG1-COG8-COG5-COG6-COG7 subcomplex;COG1-COG8-COG2-COG3-COG4 subcomplex;COG complex6COG5, COG7, COG2, COG4, COG6, COG3
COG8COG7YesConserved oligomeric Golgi (COG) complex;COG1-COG8-COG5-COG6-COG7 subcomplex;Tetrameric COG subcomplex;COG complex6COG5, COG2, COG1, COG4, COG6, COG3
COG8COG6YesConserved oligomeric Golgi (COG) complex;COG1-COG8-COG5-COG6-COG7 subcomplex;Tetrameric COG subcomplex;COG complex6COG5, COG7, COG2, COG1, COG4, COG3
COG8COG5YesConserved oligomeric Golgi (COG) complex;COG1-COG8-COG5-COG6-COG7 subcomplex;Tetrameric COG subcomplex;COG complex6COG7, COG2, COG1, COG4, COG6, COG3
COG8COG4YesConserved oligomeric Golgi (COG) complex;COG1-COG8-COG2-COG3-COG4 subcomplex;COG complex6COG5, COG7, COG2, COG1, COG6, COG3
COG1COG7YesConserved oligomeric Golgi (COG) complex;COG1-COG8-COG5-COG6-COG7 subcomplex;COG complex6COG5, COG8, COG2, COG4, COG6, COG3
COG1COG6YesConserved oligomeric Golgi (COG) complex;COG1-COG8-COG5-COG6-COG7 subcomplex;COG complex6COG5, COG7, COG8, COG4, COG2, COG3
COG1COG5YesConserved oligomeric Golgi (COG) complex;COG1-COG8-COG5-COG6-COG7 subcomplex;COG complex6COG7, COG8, COG2, COG4, COG6, COG3
COG1COG4YesConserved oligomeric Golgi (COG) complex;COG1-COG8-COG2-COG3-COG4 subcomplex;COG complex6COG5, COG7, COG8, COG6, COG2, COG3
COG7COG6YesConserved oligomeric Golgi (COG) complex;Ternary COG subcomplex;COG5-COG6-COG7 subcomplex;Tetrameric COG subcomplex;COG complex;COG1-COG8-COG5-COG6-COG7 subcomplex6COG5, COG8, COG1, COG4, COG2, COG3
COG7COG5YesConserved oligomeric Golgi (COG) complex;Ternary COG subcomplex;COG5-COG6-COG7 subcomplex;Tetrameric COG subcomplex;Binary COG subcomplex;COG complex;COG1-COG8-COG5-COG6-COG7 subcomplex6COG8, COG1, COG6, COG4, COG2, COG3
COG7COG4YesConserved oligomeric Golgi (COG) complex;COG complex6COG5, COG8, COG1, COG6, COG2, COG3
COG6COG5YesConserved oligomeric Golgi (COG) complex;Ternary COG subcomplex;COG5-COG6-COG7 subcomplex;Tetrameric COG subcomplex;COG complex;COG1-COG8-COG5-COG6-COG7 subcomplex6COG7, COG8, COG1, COG4, COG2, COG3
COG6COG4YesConserved oligomeric Golgi (COG) complex;COG complex6COG5, COG7, COG8, COG1, COG2, COG3
COG5COG4YesConserved oligomeric Golgi (COG) complex;COG complex6COG7, COG8, COG1, COG6, COG2, COG3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
COG8COG1Yes6COG5, COG7, COG2, COG4, COG6, COG3
COG8COG7Yes6COG5, COG2, COG1, COG4, COG6, COG3
COG8COG6Yes5COG2, COG7, COG1, COG3, COG5
COG8COG5Yes6COG7, COG2, COG1, COG4, COG6, COG3
COG8COG4Yes4COG7, COG1, COG3, COG5
COG1COG7Yes6COG5, COG8, COG2, COG4, COG6, COG3
COG1COG6Yes5COG2, COG7, COG8, COG3, COG5
COG1COG5Yes6COG7, COG8, COG2, COG4, COG6, COG3
COG1COG4Yes4COG8, COG7, COG3, COG5
COG7COG6Yes5COG8, COG2, COG1, COG3, COG5
COG7COG5Yes6COG8, COG1, COG6, COG4, COG2, COG3
COG7COG4Yes4COG8, COG1, COG3, COG5
COG6COG5Yes5COG8, COG2, COG7, COG1, COG3
COG6COG4No5COG8, COG7, COG1, COG3, COG5
COG5COG4Yes4COG8, COG7, COG1, COG3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Metabolic pathwayshsa011002.493B4GALT1, MGAT2, MOGS
N-Glycan biosynthesishsa005107.073B4GALT1, MGAT2, MOGS

NET-GE enrichment

Term New enriched termICP valueGenes
Global and overview mapsNEW2.470.032TMEM199, B4GALT1, MGAT2, MOGS, SLC35A2
N-Glycan biosynthesis (hsa00510) -7.070.0B4GALT1, MGAT2, MOGS
Glycan biosynthesis and metabolismNEW4.780.001B4GALT1, MGAT2, MOGS
Metabolic pathways (hsa01100) -2.490.03TMEM199, B4GALT1, MGAT2, MOGS, SLC35A2
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
SLC-mediated transmembrane transportR-HSA-4254074.954SLC35A1, SLC35C1, SLC35A2, SLC39A8
Post-translational protein modificationR-HSA-5975924.544SLC35A1, B4GALT1, MGAT2, MOGS
Metabolism of proteinsR-HSA-3924993.414SLC35A1, B4GALT1, MGAT2, MOGS
Transmembrane transport of small moleculesR-HSA-3825513.794SLC35A1, SLC35C1, SLC35A2, SLC39A8
Asparagine N-linked glycosylationR-HSA-4462036.14SLC35A1, B4GALT1, MGAT2, MOGS
Diseases of glycosylationR-HSA-37818656.893B4GALT1, MGAT2, MOGS
Diseases associated with N-glycosylation of proteinsR-HSA-37818608.893B4GALT1, MGAT2, MOGS
Transport of nucleotide sugarsR-HSA-7278029.813SLC35A1, SLC35C1, SLC35A2
DiseaseR-HSA-16436853.333B4GALT1, MGAT2, MOGS
Transport of vitamins, nucleosides, and related moleculesR-HSA-4253977.733SLC35A1, SLC35C1, SLC35A2
Transport to the Golgi and subsequent modificationR-HSA-9480217.812B4GALT1, MGAT2
N-glycan antennae elongation in the medial/trans-GolgiR-HSA-9755768.662B4GALT1, MGAT2

NET-GE enrichment

Term New enriched termICP valueGenes
Transport of nucleotide sugars (R-HSA-727802) -9.810.0SLC35A1, SLC35C1, SLC35A2
Transport of vitamins, nucleosides, and related molecules (R-HSA-425397) -7.730.0SLC35A1, SLC35C1, SLC35A2
Transmembrane transport of small molecules (R-HSA-382551) -3.790.033SLC35A1, SLC35C1, SLC35A2, SLC39A8
Asparagine N-linked glycosylation (R-HSA-446203) -6.10.0SLC35A1, B4GALT1, MGAT2, MOGS
Diseases of glycosylation (R-HSA-3781865) -6.890.001B4GALT1, MGAT2, MOGS
SLC-mediated transmembrane transport (R-HSA-425407) -4.950.009SLC35A1, SLC35C1, SLC35A2, SLC39A8
Post-translational protein modification (R-HSA-597592) -4.540.029SLC35A1, B4GALT1, MGAT2, MOGS
Transport to the Golgi and subsequent modification (R-HSA-948021) -7.810.016B4GALT1, MGAT2
Diseases associated with N-glycosylation of proteins (R-HSA-3781860) -8.890.0B4GALT1, MGAT2, MOGS
N-glycan antennae elongation in the medial/trans-Golgi (R-HSA-975576) -8.660.005B4GALT1, MGAT2
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.189TMEM199, B4GALT1, COG5, COG7, COG8, COG1, SLC35A2, COG4, MGAT2
protein binding (GO:0005515) 0.468TMEM199, B4GALT1, COG5, COG7, COG8, COG1, SLC35A2, COG4
substrate-specific transmembrane transporter activity (GO:0022891) 2.94SLC35A1, SLC35C1, SLC35A2, SLC39A8
transporter activity (GO:0005215) 2.574SLC35A1, SLC35C1, SLC35A2, SLC39A8
transmembrane transporter activity (GO:0022857) 2.824SLC35A1, SLC35C1, SLC35A2, SLC39A8
substrate-specific transporter activity (GO:0022892) 2.724SLC35A1, SLC35C1, SLC35A2, SLC39A8
nucleobase-containing compound transmembrane transporter activity (GO:0015932) 6.343SLC35A1, SLC35C1, SLC35A2
cation transmembrane transporter activity (GO:0008324) 3.323SLC35A1, SLC35A2, SLC39A8
nucleotide-sugar transmembrane transporter activity (GO:0005338) 7.543SLC35A1, SLC35C1, SLC35A2
ion transmembrane transporter activity (GO:0015075) 3.043SLC35A1, SLC35A2, SLC39A8
catalytic activity (GO:0003824) 1.053B4GALT1, MGAT2, MOGS
carbohydrate derivative transporter activity (GO:1901505) 6.183SLC35A1, SLC35C1, SLC35A2
solute:proton symporter activity (GO:0015295) 6.482SLC35A1, SLC35A2
solute:cation symporter activity (GO:0015294) 5.152SLC35A1, SLC35A2
sugar:proton symporter activity (GO:0005351) 7.032SLC35A1, SLC35A2
transferase activity, transferring glycosyl groups (GO:0016757) 4.082B4GALT1, MGAT2
symporter activity (GO:0015293) 4.782SLC35A1, SLC35A2
sugar transmembrane transporter activity (GO:0051119) 6.32SLC35A1, SLC35A2
carbohydrate transporter activity (GO:1901476) 5.952SLC35A1, SLC35A2
transferase activity, transferring hexosyl groups (GO:0016758) 4.432B4GALT1, MGAT2
transferase activity (GO:0016740) 1.952B4GALT1, MGAT2
pyrimidine nucleotide-sugar transmembrane transporter activity (GO:0015165) 7.792SLC35A1, SLC35A2
cation:sugar symporter activity (GO:0005402) 7.032SLC35A1, SLC35A2
secondary active transmembrane transporter activity (GO:0015291) 4.292SLC35A1, SLC35A2
UDP-glycosyltransferase activity (GO:0008194) 4.812B4GALT1, MGAT2
carbohydrate transmembrane transporter activity (GO:0015144) 5.952SLC35A1, SLC35A2
active transmembrane transporter activity (GO:0022804) 3.852SLC35A1, SLC35A2

NET-GE enrichment

Term New enriched termICP valueGenes
solute (GO:0015295) -6.480.007SLC35A1, SLC35A2
nucleobase-containing compound transmembrane transporter activity (GO:0015932) -6.340.008SLC35A1, SLC35A2
sugar (GO:0005351) -7.030.001SLC35A1, SLC35A2
sugar transmembrane transporter activity (GO:0051119) -6.30.005SLC35A1, SLC35A2
carbohydrate transporter activity (GO:1901476) -5.950.02SLC35A1, SLC35A2
nucleotide-sugar transmembrane transporter activity (GO:0005338) -7.540.0SLC35A1, SLC35A2
cation (GO:0005402) -7.030.001SLC35A1, SLC35A2
organophosphate ester transmembrane transporter activity (GO:0015605) NEW7.10.002SLC35A1, SLC35A2
nucleotide transmembrane transporter activity (GO:0015215) NEW7.440.004SLC35A1, SLC35A2
pyrimidine nucleotide-sugar transmembrane transporter activity (GO:0015165) -7.790.0SLC35A1, SLC35A2
carbohydrate derivative transporter activity (GO:1901505) -6.180.008SLC35A1, SLC35A2
phosphate transmembrane transporter activity (GO:1901677) NEW6.690.008SLC35A1, SLC35A2
carbohydrate transmembrane transporter activity (GO:0015144) -5.950.02SLC35A1, SLC35A2
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
transport (GO:0006810) 1.5111COG5, COG7, SLC35C1, COG8, COG1, SLC35A1, SLC35A2, TMEM165, COG4, COG6, SLC39A8
localization (GO:0051179) 1.411COG5, COG7, SLC35C1, COG8, COG1, SLC35A1, SLC35A2, TMEM165, COG4, COG6, SLC39A8
establishment of localization (GO:0051234) 1.4811COG5, COG7, SLC35C1, COG8, COG1, SLC35A1, SLC35A2, TMEM165, COG4, COG6, SLC39A8
cellular process (GO:0009987) 0.2610B4GALT1, MOGS, COG7, SLC35C1, COG1, SLC35A1, TMEM165, COG4, MGAT2, SLC39A8
single-organism process (GO:0044699) 0.4810B4GALT1, MOGS, COG7, SLC35C1, SLC35A1, SLC35A2, TMEM165, COG6, MGAT2, SLC39A8
organic substance metabolic process (GO:0071704) 0.639B4GALT1, MOGS, COG7, SLC35C1, SLC35A1, SLC35A2, TMEM165, COG6, MGAT2
primary metabolic process (GO:0044238) 0.699B4GALT1, MOGS, COG7, SLC35C1, SLC35A1, SLC35A2, TMEM165, COG6, MGAT2
carbohydrate metabolic process (GO:0005975) 3.269B4GALT1, MOGS, COG7, SLC35C1, SLC35A1, SLC35A2, TMEM165, COG6, MGAT2
metabolic process (GO:0008152) 0.589B4GALT1, MOGS, COG7, SLC35C1, SLC35A1, SLC35A2, TMEM165, COG6, MGAT2
organic substance transport (GO:0071702) 2.159COG5, COG7, SLC35C1, COG8, COG1, SLC35A1, SLC35A2, COG4, COG6
single-organism carbohydrate metabolic process (GO:0044723) 3.428B4GALT1, MOGS, COG7, SLC35C1, SLC35A2, TMEM165, COG6, MGAT2
single-organism metabolic process (GO:0044710) 1.638B4GALT1, MOGS, COG7, SLC35C1, SLC35A2, TMEM165, COG6, MGAT2
single-organism cellular process (GO:0044763) 0.657B4GALT1, MOGS, COG7, SLC35C1, TMEM165, MGAT2, SLC39A8
glycosylation (GO:0070085) 4.167B4GALT1, MOGS, COG7, SLC35C1, TMEM165, COG6, MGAT2
cellular metabolic process (GO:0044237) 0.697B4GALT1, MOGS, COG7, SLC35C1, SLC35A1, TMEM165, MGAT2
cellular protein metabolic process (GO:0044267) 1.636B4GALT1, MOGS, COG7, SLC35A1, TMEM165, MGAT2
protein localization (GO:0008104) 2.366COG5, COG7, COG8, COG1, COG4, COG6
ER to Golgi vesicle-mediated transport (GO:0006888) 4.76COG5, COG7, COG8, COG1, COG4, COG6
vesicle-mediated transport (GO:0016192) 2.726COG5, COG7, COG8, COG1, COG4, COG6
cellular macromolecule metabolic process (GO:0044260) 0.936B4GALT1, MOGS, COG7, SLC35A1, TMEM165, MGAT2
Golgi vesicle transport (GO:0048193) 4.076COG5, COG7, COG8, COG1, COG4, COG6
protein metabolic process (GO:0019538) 1.456B4GALT1, MOGS, COG7, SLC35A1, TMEM165, MGAT2
cellular protein modification process (GO:0006464) 1.796B4GALT1, MOGS, COG7, SLC35A1, TMEM165, MGAT2
macromolecule metabolic process (GO:0043170) 0.836B4GALT1, MOGS, COG7, SLC35A1, TMEM165, MGAT2
establishment of protein localization (GO:0045184) 2.536COG5, COG7, COG8, COG1, COG4, COG6
intracellular transport (GO:0046907) 2.676COG5, COG7, COG8, COG1, COG4, COG6
macromolecule modification (GO:0043412) 1.736B4GALT1, MOGS, COG7, SLC35A1, TMEM165, MGAT2
protein modification process (GO:0036211) 1.796B4GALT1, MOGS, COG7, SLC35A1, TMEM165, MGAT2
establishment of localization in cell (GO:0051649) 2.476COG5, COG7, COG8, COG1, COG4, COG6
protein transport (GO:0015031) 2.626COG5, COG7, COG8, COG1, COG4, COG6
macromolecule localization (GO:0033036) 2.346COG5, COG7, COG8, COG1, COG4, COG6
cellular localization (GO:0051641) 2.326COG5, COG7, COG8, COG1, COG4, COG6
intra-Golgi vesicle-mediated transport (GO:0006891) 5.865COG4, COG8, COG6, COG1, COG5
protein glycosylation (GO:0006486) 4.25B4GALT1, MGAT2, COG7, MOGS, TMEM165
cellular component organization (GO:0016043) 1.245SLC35C1, B4GALT1, COG7, COG4, COG1
macromolecule glycosylation (GO:0043413) 4.25B4GALT1, MGAT2, COG7, MOGS, TMEM165
biological regulation (GO:0065007) 0.395SLC35C1, B4GALT1, COG7, SLC39A8, TMEM165
cellular component organization or biogenesis (GO:0071840) 1.225SLC35C1, B4GALT1, COG7, COG4, COG1
organelle organization (GO:0006996) 2.024SLC35C1, COG4, COG7, COG1
cation transport (GO:0006812) 3.114SLC35A1, SLC35A2, TMEM165, SLC39A8
ion transport (GO:0006811) 2.664SLC35A1, SLC35A2, TMEM165, SLC39A8
protein N-linked glycosylation (GO:0006487) 5.654B4GALT1, MGAT2, TMEM165, MOGS
nucleobase-containing compound transport (GO:0015931) 4.423SLC35A1, SLC35C1, SLC35A2
Golgi organization (GO:0007030) 5.33COG4, COG7, COG1
nucleotide-sugar transport (GO:0015780) 7.533SLC35A1, SLC35C1, SLC35A2
oligosaccharide metabolic process (GO:0009311) 5.543B4GALT1, MGAT2, MOGS
carbohydrate transport (GO:0008643) 5.163SLC35A1, SLC35C1, SLC35A2
nitrogen compound transport (GO:0071705) 3.543SLC35A1, SLC35C1, SLC35A2
single-organism transport (GO:0044765) 2.183SLC35A1, SLC35C1, SLC35A2
regulation of biological quality (GO:0065008) 1.683COG7, SLC39A8, TMEM165
single-organism localization (GO:1902578) 2.093SLC35A1, SLC35C1, SLC35A2
carbohydrate derivative transport (GO:1901264) 5.843SLC35A1, SLC35C1, SLC35A2
ion homeostasis (GO:0050801) 3.422TMEM165, SLC39A8
retrograde transport, vesicle recycling within Golgi (GO:0000301) 6.552COG4, COG1
oligosaccharide biosynthetic process (GO:0009312) 7.162B4GALT1, MGAT2
homeostatic process (GO:0042592) 2.612TMEM165, SLC39A8
small molecule metabolic process (GO:0044281) 2.382B4GALT1, SLC35A2
inorganic ion homeostasis (GO:0098771) 3.432TMEM165, SLC39A8
carbohydrate biosynthetic process (GO:0016051) 4.932B4GALT1, MGAT2
regulation of biological process (GO:0050789) 0.452SLC35C1, B4GALT1
organic substance biosynthetic process (GO:1901576) 1.342B4GALT1, MGAT2
single-organism biosynthetic process (GO:0044711) 2.82B4GALT1, MGAT2
proton transport (GO:0015992) 4.732SLC35A1, SLC35A2
cellular divalent inorganic cation homeostasis (GO:0072503) 3.962TMEM165, SLC39A8
galactose metabolic process (GO:0006012) 7.092B4GALT1, SLC35A2
negative regulation of biological process (GO:0048519) 1.332SLC35C1, B4GALT1
monovalent inorganic cation transport (GO:0015672) 3.742SLC35A1, SLC35A2
cellular homeostasis (GO:0019725) 3.232TMEM165, SLC39A8
hydrogen transport (GO:0006818) 4.722SLC35A1, SLC35A2
divalent inorganic cation homeostasis (GO:0072507) 3.92TMEM165, SLC39A8
cellular metal ion homeostasis (GO:0006875) 3.752TMEM165, SLC39A8
hexose metabolic process (GO:0019318) 4.642B4GALT1, SLC35A2
cellular ion homeostasis (GO:0006873) 3.572TMEM165, SLC39A8
regulation of cellular process (GO:0050794) 0.52SLC35C1, B4GALT1
regulation of multi-organism process (GO:0043900) 3.62SLC35C1, B4GALT1
metal ion transport (GO:0030001) 3.362TMEM165, SLC39A8
cellular cation homeostasis (GO:0030003) 3.62TMEM165, SLC39A8
metal ion homeostasis (GO:0055065) 3.612TMEM165, SLC39A8
cation homeostasis (GO:0055080) 3.462TMEM165, SLC39A8
divalent metal ion transport (GO:0070838) 4.152TMEM165, SLC39A8
cellular chemical homeostasis (GO:0055082) 3.42TMEM165, SLC39A8
transmembrane transport (GO:0055085) 2.722SLC35A2, SLC39A8
retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) 5.382COG4, COG7
divalent inorganic cation transport (GO:0072511) 4.132TMEM165, SLC39A8
monosaccharide metabolic process (GO:0005996) 4.572B4GALT1, SLC35A2
pyrimidine nucleotide-sugar transport (GO:0015781) 7.652SLC35A1, SLC35A2
biosynthetic process (GO:0009058) 1.322B4GALT1, MGAT2
chemical homeostasis (GO:0048878) 2.972TMEM165, SLC39A8
negative regulation of cellular process (GO:0048523) 1.412SLC35C1, B4GALT1

NET-GE enrichment

Term New enriched termICP valueGenes
nucleotide transport (GO:0006862) NEW6.90.024SLC35A1, SLC35A2
oligosaccharide biosynthetic process (GO:0009312) -7.160.043B4GALT1, MGAT2
protein glycosylation (GO:0006486) -4.20.001B4GALT1, MOGS, COG7, TMEM165, COG6, MGAT2
protein N-linked glycosylation (GO:0006487) -5.650.0MOGS, B4GALT1, MGAT2, TMEM165
peptidyl-asparagine modification (GO:0018196) NEW6.070.013B4GALT1, MGAT2, MOGS
carbohydrate transport (GO:0008643) -5.160.016SLC35A1, SLC35C1, SLC35A2
galactose metabolic process (GO:0006012) -7.090.036B4GALT1, SLC35A2
organic substance transport (GO:0071702) -2.150.0COG5, COG7, SLC35C1, COG8, COG1, SLC35A1, SLC35A2, COG4, COG6
protein N-linked glycosylation via asparagine (GO:0018279) NEW6.090.013B4GALT1, MGAT2, MOGS
Golgi vesicle transport (GO:0048193) -4.070.0COG7, MOGS, COG5, COG1, COG4, COG6
oligosaccharide metabolic process (GO:0009311) -5.540.011B4GALT1, MGAT2, MOGS
transport (GO:0006810) -1.510.001COG5, COG7, SLC35C1, COG8, COG1, SLC35A1, SLC35A2, TMEM165, COG4, COG6, SLC39A8
glycosylation (GO:0070085) -4.160.0B4GALT1, MOGS, COG7, SLC35C1, TMEM165, COG6, MGAT2
establishment of protein localization (GO:0045184) -2.530.045COG5, COG7, COG8, COG1, COG4, COG6
single-organism transport (GO:0044765) -2.180.001COG5, COG7, SLC35C1, COG1, SLC35A1, SLC35A2, TMEM165, COG4, COG6, SLC39A8
macromolecule glycosylation (GO:0043413) -4.20.001B4GALT1, MOGS, COG7, TMEM165, COG6, MGAT2
single-organism carbohydrate metabolic process (GO:0044723) -3.420.0B4GALT1, MOGS, COG7, SLC35C1, SLC35A2, TMEM165, COG6, MGAT2
establishment of localization (GO:0051234) -1.480.001COG5, COG7, SLC35C1, COG8, COG1, SLC35A1, SLC35A2, TMEM165, COG4, COG6, SLC39A8
localization (GO:0051179) -1.40.003COG5, COG7, SLC35C1, COG8, COG1, SLC35A1, SLC35A2, TMEM165, COG4, COG6, SLC39A8
nucleotide transmembrane transport (GO:1901679) NEW7.780.016SLC35A1, SLC35A2
intra-Golgi vesicle-mediated transport (GO:0006891) -5.860.001COG6, COG5, COG1
retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) -5.380.045COG4, COG7
carbohydrate metabolic process (GO:0005975) -3.260.001B4GALT1, MOGS, COG7, SLC35C1, SLC35A1, SLC35A2, TMEM165, COG6, MGAT2
intracellular transport (GO:0046907) -2.670.04COG5, COG7, COG1, TMEM165, COG4, COG6
pyrimidine nucleotide-sugar transport (GO:0015781) -7.650.002SLC35A1, SLC35A2
nucleotide-sugar transport (GO:0015780) -7.530.003SLC35A1, SLC35A2
protein transport (GO:0015031) -2.620.033COG5, COG7, COG8, COG1, COG4, COG6
single-organism intracellular transport (GO:1902582) NEW3.590.01MOGS, COG7, COG5, COG8, COG1, SLC35A2, TMEM165, COG4, COG6
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
membrane (GO:0016020) 0.6816TMEM199, B4GALT1, MOGS, COG7, COG5, SLC35C1, COG8, MGAT2, COG1, SLC35A1, SLC35A2, CCDC115, TMEM165, COG6, COG4, SLC39A8
cell part (GO:0044464) 0.1116TMEM199, B4GALT1, COG5, COG7, SLC35C1, MOGS, COG8, MGAT2, COG1, SLC35A1, SLC35A2, CCDC115, TMEM165, COG6, COG4, SLC39A8
organelle part (GO:0044422) 0.7916TMEM199, B4GALT1, COG5, COG7, SLC35C1, MOGS, COG8, MGAT2, COG1, SLC35A1, SLC35A2, CCDC115, TMEM165, COG6, COG4, SLC39A8
intracellular part (GO:0044424) 0.2815TMEM199, B4GALT1, MOGS, COG7, COG5, SLC35C1, COG8, MGAT2, COG1, SLC35A1, SLC35A2, CCDC115, TMEM165, COG6, COG4
intracellular organelle part (GO:0044446) 0.8115TMEM199, B4GALT1, MOGS, COG7, COG5, SLC35C1, COG8, MGAT2, COG1, SLC35A1, SLC35A2, CCDC115, TMEM165, COG6, COG4
cytoplasmic part (GO:0044444) 0.8215TMEM199, B4GALT1, MOGS, COG7, COG5, SLC35C1, COG8, MGAT2, COG1, SLC35A1, SLC35A2, CCDC115, TMEM165, COG6, COG4
membrane-bounded organelle (GO:0043227) 0.4715TMEM199, B4GALT1, MOGS, COG7, COG5, SLC35C1, COG8, MGAT2, COG1, SLC35A1, SLC35A2, CCDC115, TMEM165, COG6, COG4
organelle (GO:0043226) 0.415TMEM199, B4GALT1, MOGS, COG7, COG5, SLC35C1, COG8, MGAT2, COG1, SLC35A1, SLC35A2, CCDC115, TMEM165, COG6, COG4
intracellular organelle (GO:0043229) 0.5114B4GALT1, MOGS, COG7, COG5, SLC35C1, COG8, MGAT2, COG1, SLC35A1, SLC35A2, CCDC115, TMEM165, COG6, COG4
intracellular membrane-bounded organelle (GO:0043231) 0.614B4GALT1, MOGS, COG7, COG5, SLC35C1, COG8, MGAT2, COG1, SLC35A1, SLC35A2, CCDC115, TMEM165, COG6, COG4
organelle membrane (GO:0031090) 1.9714TMEM199, B4GALT1, COG5, COG7, SLC35C1, COG8, MGAT2, COG1, SLC35A1, SLC35A2, TMEM165, COG4, COG6, SLC39A8
Golgi apparatus part (GO:0044431) 3.014TMEM199, B4GALT1, COG5, COG7, SLC35C1, COG8, MGAT2, COG1, SLC35A1, SLC35A2, CCDC115, TMEM165, COG6, COG4
bounding membrane of organelle (GO:0098588) 2.3913TMEM199, B4GALT1, COG5, COG7, SLC35C1, COG8, MGAT2, COG1, SLC35A1, SLC35A2, TMEM165, COG4, COG6
Golgi apparatus (GO:0005794) 2.712B4GALT1, COG5, COG7, SLC35C1, COG8, MGAT2, COG1, SLC35A1, SLC35A2, TMEM165, COG4, COG6
Golgi membrane (GO:0000139) 3.2812B4GALT1, COG5, COG7, SLC35C1, COG8, MGAT2, COG1, SLC35A1, SLC35A2, TMEM165, COG4, COG6
membrane part (GO:0044425) 0.959TMEM199, B4GALT1, MOGS, SLC35C1, SLC35A1, SLC35A2, TMEM165, MGAT2, SLC39A8
integral component of membrane (GO:0016021) 1.149TMEM199, B4GALT1, MOGS, SLC35C1, SLC35A1, SLC35A2, TMEM165, MGAT2, SLC39A8
intrinsic component of membrane (GO:0031224) 1.139TMEM199, B4GALT1, MOGS, SLC35C1, SLC35A1, SLC35A2, TMEM165, MGAT2, SLC39A8
trans-Golgi network membrane (GO:0032588) 5.47COG5, COG7, COG8, COG1, TMEM165, COG4, COG6
protein complex (GO:0043234) 1.516COG5, COG7, COG8, COG1, COG4, COG6
macromolecular complex (GO:0032991) 1.356COG5, COG7, COG8, COG1, COG4, COG6
(GO:0099023) 5.726COG5, COG7, COG8, COG1, COG4, COG6
Golgi transport complex (GO:0017119) 7.166COG5, COG7, COG8, COG1, COG4, COG6
vesicle (GO:0031982) 1.644TMEM199, B4GALT1, CCDC115, MOGS
plasma membrane part (GO:0044459) 1.953SLC35A1, B4GALT1, SLC39A8
membrane-bounded vesicle (GO:0031988) 1.713B4GALT1, CCDC115, MOGS
endosome (GO:0005768) 3.252CCDC115, TMEM165
organelle subcompartment (GO:0031984) 4.552B4GALT1, MGAT2
extracellular organelle (GO:0043230) 1.892B4GALT1, MOGS
endoplasmic reticulum (GO:0005783) 2.562SLC35A2, MOGS
vacuole (GO:0005773) 2.922CCDC115, TMEM165
cytoplasmic vesicle (GO:0031410) 2.872TMEM199, CCDC115
whole membrane (GO:0098805) 2.852TMEM199, TMEM165
lysosome (GO:0005764) 3.892CCDC115, TMEM165
Golgi subcompartment (GO:0098791) 4.632B4GALT1, MGAT2
nuclear part (GO:0044428) 1.552COG5, COG7
intracellular vesicle (GO:0097708) 2.862TMEM199, CCDC115
integral component of plasma membrane (GO:0005887) 2.572SLC35A1, SLC39A8
plasma membrane (GO:0005886) 1.392B4GALT1, SLC39A8
lytic vacuole (GO:0000323) 3.892CCDC115, TMEM165
extracellular vesicle (GO:1903561) 1.892B4GALT1, MOGS
intrinsic component of plasma membrane (GO:0031226) 2.532SLC35A1, SLC39A8
extracellular region part (GO:0044421) 1.572B4GALT1, MOGS
extracellular exosome (GO:0070062) 1.892B4GALT1, MOGS

NET-GE enrichment

Term New enriched termICP valueGenes
Golgi apparatus (GO:0005794) -2.70.0B4GALT1, COG5, COG7, MOGS, COG1, SLC35A1, SLC35A2, TMEM165, COG4, COG6
Golgi transport complex (GO:0017119) -7.160.0COG5, COG7, COG8, COG1, COG4, COG6
bounding membrane of organelle (GO:0098588) -2.390.0B4GALT1, MOGS, COG7, COG5, SLC35C1, COG8, MGAT2, COG1, SLC35A1, SLC35A2, TMEM165, COG4, COG6
membrane (GO:0016020) -0.680.0B4GALT1, MOGS, COG7, COG5, SLC35C1, COG8, MGAT2, COG1, SLC35A1, SLC35A2, CCDC115, TMEM165, COG6, COG4, SLC39A8
Golgi apparatus part (GO:0044431) -3.00.0B4GALT1, COG5, COG7, SLC35C1, COG8, MGAT2, COG1, SLC35A1, SLC35A2, TMEM165, COG4, COG6
Golgi membrane (GO:0000139) -3.280.0B4GALT1, COG5, COG7, SLC35C1, COG8, MGAT2, COG1, SLC35A1, SLC35A2, TMEM165, COG4, COG6
intracellular organelle part (GO:0044446) -0.810.021B4GALT1, MOGS, COG7, COG5, SLC35C1, COG8, MGAT2, COG1, SLC35A1, SLC35A2, TMEM165, COG4, COG6
cytoplasmic part (GO:0044444) -0.820.007B4GALT1, COG5, COG7, SLC35C1, MOGS, COG8, MGAT2, COG1, SLC35A1, SLC35A2, CCDC115, TMEM165, COG6, COG4
Golgi cisterna membrane (GO:0032580) NEW5.50.036COG4, B4GALT1, COG6
organelle part (GO:0044422) -0.790.003B4GALT1, MOGS, COG7, COG5, SLC35C1, COG8, MGAT2, COG1, SLC35A1, SLC35A2, TMEM165, COG4, COG6, SLC39A8
organelle membrane (GO:0031090) -1.970.0TMEM199, B4GALT1, MOGS, COG7, COG5, SLC35C1, COG8, MGAT2, COG1, SLC35A1, SLC35A2, TMEM165, COG4, COG6, SLC39A8