Disease table of HYPOALPHALIPOPROTEINEMIA, PRIMARY OMIM ID: 604091

Gene-disease associations table

GeneAssociated with HYPOALPHALIPOPROTEINEMIA, PRIMARY inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
APOA1ClinVar, OMIMHGNC link11q23.33205400, 105200, 604091
ABCA1ClinVar, OMIM, HUMSAVARHGNC link9q31.13205400, 143890, 604091

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC12APOA1, ABCA1
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
APOA1YES4SP1, GATA6, FOXA2, HNF4A0
ABCA1YES11SP1, SREBF2, NR1H3, USF2, ZNF202, RELA, SP3, RXRA, NFKB1, NR1H2, USF10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
APOA1ABCA1Yes1APOA1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
APOA1ABCA1Yesbinding20SP1, LRP1, CARM1, SMARCD3, APOE, TBL1XR1, NCOA6, NR1H3, HELZ2, CHD9, TGS1, MED1, NCOA1, PLTP, NCOA2, LRP8, TBL1X, PPARA, CREBBP, APOB

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
ABCA1APOA1yes, they interactThey are in interaction. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Fat digestion and absorptionhsa049757.452APOA1, ABCA1

NET-GE enrichment

Term New enriched termICP valueGenes
Membrane transportNEW7.280.002APOA1, ABCA1
ABC transporters (hsa02010) NEW7.280.002APOA1, ABCA1
Digestive systemNEW4.120.043APOA1, ABCA1
Fat digestion and absorption (hsa04975) -7.450.004APOA1, ABCA1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
PPARA activates gene expressionR-HSA-19897816.182APOA1, ABCA1
Lipoprotein metabolismR-HSA-1748248.232APOA1, ABCA1
HDL-mediated lipid transportR-HSA-1942239.082APOA1, ABCA1
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)R-HSA-4002066.142APOA1, ABCA1
Lipid digestion, mobilization, and transportR-HSA-739237.22APOA1, ABCA1
MetabolismR-HSA-14307282.342APOA1, ABCA1
Fatty acid, triacylglycerol, and ketone body metabolismR-HSA-5357345.442APOA1, ABCA1
Metabolism of lipids and lipoproteinsR-HSA-5568333.792APOA1, ABCA1

NET-GE enrichment

Term New enriched termICP valueGenes
PPARA activates gene expression (R-HSA-1989781) -6.180.005APOA1, ABCA1
Lipoprotein metabolism (R-HSA-174824) -8.230.001APOA1, ABCA1
Metabolism of vitamins and cofactors (R-HSA-196854) NEW6.540.018APOA1, ABCA1
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (R-HSA-400206) -6.140.005APOA1, ABCA1
Lipid digestion, mobilization, and transport (R-HSA-73923) -7.20.001APOA1, ABCA1
ABC transporters in lipid homeostasis (R-HSA-1369062) NEW9.080.0APOA1, ABCA1
Fatty acid, triacylglycerol, and ketone body metabolism (R-HSA-535734) -5.440.014APOA1, ABCA1
HDL-mediated lipid transport (R-HSA-194223) -9.080.0APOA1, ABCA1
Metabolism of water-soluble vitamins and cofactors (R-HSA-196849) NEW6.540.018APOA1, ABCA1
ABC-family proteins mediated transport (R-HSA-382556) NEW7.590.004APOA1, ABCA1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
phospholipid transporter activity (GO:0005548) 5.872APOA1, ABCA1
lipid transporter activity (GO:0005319) 5.032APOA1, ABCA1
sterol binding (GO:0032934) 5.982APOA1, ABCA1
cholesterol binding (GO:0015485) 6.12APOA1, ABCA1
alcohol binding (GO:0043178) 5.532APOA1, ABCA1
organic cyclic compound binding (GO:0097159) 1.052APOA1, ABCA1
phospholipid binding (GO:0005543) 3.912APOA1, ABCA1
lipid binding (GO:0008289) 3.262APOA1, ABCA1
enzyme binding (GO:0019899) 2.272APOA1, ABCA1
small molecule binding (GO:0036094) 1.892APOA1, ABCA1
substrate-specific transporter activity (GO:0022892) 2.722APOA1, ABCA1
binding (GO:0005488) 0.182APOA1, ABCA1
protein binding (GO:0005515) 0.462APOA1, ABCA1
transporter activity (GO:0005215) 2.572APOA1, ABCA1
steroid binding (GO:0005496) 5.242APOA1, ABCA1
sterol transporter activity (GO:0015248) 6.852APOA1, ABCA1
cholesterol transporter activity (GO:0017127) 7.172APOA1, ABCA1
receptor binding (GO:0005102) 2.432APOA1, ABCA1

NET-GE enrichment

Term New enriched termICP valueGenes
phospholipid transporter activity (GO:0005548) -5.870.002APOA1, ABCA1
lipid transporter activity (GO:0005319) -5.030.014APOA1, ABCA1
cholesterol binding (GO:0015485) -6.10.003APOA1, ABCA1
alcohol binding (GO:0043178) -5.530.002APOA1, ABCA1
phospholipid binding (GO:0005543) -3.910.021APOA1, ABCA1
steroid binding (GO:0005496) -5.240.026APOA1, ABCA1
sterol binding (GO:0032934) -5.980.0APOA1, ABCA1
phosphatidylcholine binding (GO:0031210) NEW6.690.0APOA1, ABCA1
apolipoprotein A-I receptor binding (GO:0034191) NEW8.350.0APOA1, ABCA1
cholesterol transporter activity (GO:0017127) -7.170.0APOA1, ABCA1
monocarboxylic acid binding (GO:0033293) NEW5.610.01APOA1, ABCA1
fatty acid binding (GO:0005504) NEW6.370.003APOA1, ABCA1
sterol transporter activity (GO:0015248) -6.850.0APOA1, ABCA1
apolipoprotein binding (GO:0034185) NEW6.970.0APOA1, ABCA1
apolipoprotein A-I binding (GO:0034186) NEW8.640.0APOA1, ABCA1
apolipoprotein receptor binding (GO:0034190) NEW7.790.0APOA1, ABCA1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of phosphate metabolic process (GO:0019220) 2.352APOA1, ABCA1
regulation of primary metabolic process (GO:0080090) 1.082APOA1, ABCA1
regulation of metabolic process (GO:0019222) 1.022APOA1, ABCA1
regulation of transport (GO:0051049) 2.242APOA1, ABCA1
regulation of response to stimulus (GO:0048583) 1.542APOA1, ABCA1
small molecule metabolic process (GO:0044281) 2.382APOA1, ABCA1
cell surface receptor signaling pathway (GO:0007166) 2.092APOA1, ABCA1
cellular component organization or biogenesis (GO:0071840) 1.222APOA1, ABCA1
cellular response to stimulus (GO:0051716) 1.972APOA1, ABCA1
regulation of signal transduction (GO:0009966) 1.842APOA1, ABCA1
positive regulation of biological process (GO:0048518) 1.22APOA1, ABCA1
negative regulation of biological process (GO:0048519) 1.332APOA1, ABCA1
regulation of small GTPase mediated signal transduction (GO:0051056) 4.082APOA1, ABCA1
secondary alcohol metabolic process (GO:1902652) 5.02APOA1, ABCA1
reverse cholesterol transport (GO:0043691) 6.842APOA1, ABCA1
response to external stimulus (GO:0009605) 2.552APOA1, ABCA1
single-multicellular organism process (GO:0044707) 1.782APOA1, ABCA1
protein metabolic process (GO:0019538) 1.452APOA1, ABCA1
response to nutrient levels (GO:0031667) 3.772APOA1, ABCA1
chemical homeostasis (GO:0048878) 2.972APOA1, ABCA1
signal transduction (GO:0007165) 1.282APOA1, ABCA1
plasma lipoprotein particle assembly (GO:0034377) 6.842APOA1, ABCA1
cellular component assembly (GO:0022607) 2.142APOA1, ABCA1
positive regulation of metabolic process (GO:0009893) 1.742APOA1, ABCA1
sterol transport (GO:0015918) 5.842APOA1, ABCA1
positive regulation of biosynthetic process (GO:0009891) 2.292APOA1, ABCA1
response to stress (GO:0006950) 1.82APOA1, ABCA1
phospholipid transport (GO:0015914) 5.672APOA1, ABCA1
regulation of signaling (GO:0023051) 1.722APOA1, ABCA1
secretion by cell (GO:0032940) 3.592APOA1, ABCA1
lipoprotein metabolic process (GO:0042157) 5.822APOA1, ABCA1
lipoprotein biosynthetic process (GO:0042158) 7.432APOA1, ABCA1
regulation of biological process (GO:0050789) 0.452APOA1, ABCA1
cellular protein metabolic process (GO:0044267) 1.632APOA1, ABCA1
cellular macromolecule metabolic process (GO:0044260) 0.932APOA1, ABCA1
cellular component organization (GO:0016043) 1.242APOA1, ABCA1
macromolecular complex assembly (GO:0065003) 2.552APOA1, ABCA1
biological regulation (GO:0065007) 0.392APOA1, ABCA1
organic cyclic compound metabolic process (GO:1901360) 1.262APOA1, ABCA1
protein-lipid complex assembly (GO:0065005) 6.682APOA1, ABCA1
regulation of biological quality (GO:0065008) 1.682APOA1, ABCA1
G-protein coupled receptor signaling pathway (GO:0007186) 2.642APOA1, ABCA1
(GO:0033700) 7.092APOA1, ABCA1
lipid metabolic process (GO:0006629) 2.682APOA1, ABCA1
transport (GO:0006810) 1.512APOA1, ABCA1
regulation of biosynthetic process (GO:0009889) 1.372APOA1, ABCA1
single-organism metabolic process (GO:0044710) 1.632APOA1, ABCA1
regulation of cellular process (GO:0050794) 0.52APOA1, ABCA1
macromolecule modification (GO:0043412) 1.732APOA1, ABCA1
protein modification process (GO:0036211) 1.792APOA1, ABCA1
metabolic process (GO:0008152) 0.582APOA1, ABCA1
cholesterol homeostasis (GO:0042632) 5.62APOA1, ABCA1
(GO:0032489) 8.342APOA1, ABCA1
regulation of intracellular signal transduction (GO:1902531) 2.312APOA1, ABCA1
secretion (GO:0046903) 3.382APOA1, ABCA1
regulation of lipid transport (GO:0032368) 5.212APOA1, ABCA1
(GO:0034380) 7.652APOA1, ABCA1
single-organism transport (GO:0044765) 2.182APOA1, ABCA1
organic hydroxy compound metabolic process (GO:1901615) 3.842APOA1, ABCA1
lipid transport (GO:0006869) 4.242APOA1, ABCA1
regulation of Ras protein signal transduction (GO:0046578) 4.492APOA1, ABCA1
cholesterol transport (GO:0030301) 5.882APOA1, ABCA1
cellular biosynthetic process (GO:0044249) 1.372APOA1, ABCA1
cellular macromolecule biosynthetic process (GO:0034645) 1.662APOA1, ABCA1
regulation of Rho protein signal transduction (GO:0035023) 5.022APOA1, ABCA1
regulation of cell communication (GO:0010646) 1.732APOA1, ABCA1
single-organism process (GO:0044699) 0.482APOA1, ABCA1
establishment of localization (GO:0051234) 1.482APOA1, ABCA1
regulation of cholesterol transport (GO:0032374) 6.092APOA1, ABCA1
organic hydroxy compound transport (GO:0015850) 4.962APOA1, ABCA1
regulation of sterol transport (GO:0032371) 6.092APOA1, ABCA1
sterol metabolic process (GO:0016125) 4.922APOA1, ABCA1
cellular process (GO:0009987) 0.262APOA1, ABCA1
lipid homeostasis (GO:0055088) 5.02APOA1, ABCA1
regulation of cell differentiation (GO:0045595) 2.422APOA1, ABCA1
regulation of localization (GO:0032879) 1.942APOA1, ABCA1
transmembrane transport (GO:0055085) 2.722APOA1, ABCA1
steroid metabolic process (GO:0008202) 4.322APOA1, ABCA1
cholesterol metabolic process (GO:0008203) 5.032APOA1, ABCA1
response to drug (GO:0042493) 3.712APOA1, ABCA1
macromolecule metabolic process (GO:0043170) 0.832APOA1, ABCA1
response to stimulus (GO:0050896) 1.222APOA1, ABCA1
response to extracellular stimulus (GO:0009991) 3.712APOA1, ABCA1
positive regulation of cellular biosynthetic process (GO:0031328) 2.32APOA1, ABCA1
macromolecular complex subunit organization (GO:0043933) 2.142APOA1, ABCA1
regulation of cellular biosynthetic process (GO:0031326) 1.382APOA1, ABCA1
positive regulation of cellular metabolic process (GO:0031325) 1.812APOA1, ABCA1
regulation of cellular metabolic process (GO:0031323) 1.072APOA1, ABCA1
homeostatic process (GO:0042592) 2.612APOA1, ABCA1
multicellular organismal process (GO:0032501) 1.452APOA1, ABCA1
sterol homeostasis (GO:0055092) 5.62APOA1, ABCA1
phospholipid homeostasis (GO:0055091) 7.532APOA1, ABCA1
protein-lipid complex subunit organization (GO:0071825) 6.152APOA1, ABCA1
plasma lipoprotein particle organization (GO:0071827) 6.232APOA1, ABCA1
organic substance metabolic process (GO:0071704) 0.632APOA1, ABCA1
organic substance transport (GO:0071702) 2.152APOA1, ABCA1
organic substance biosynthetic process (GO:1901576) 1.342APOA1, ABCA1
response to nutrient (GO:0007584) 4.492APOA1, ABCA1
cellular protein modification process (GO:0006464) 1.792APOA1, ABCA1
regulation of phosphorus metabolic process (GO:0051174) 2.352APOA1, ABCA1
biosynthetic process (GO:0009058) 1.322APOA1, ABCA1
macromolecule biosynthetic process (GO:0009059) 1.612APOA1, ABCA1
single-organism cellular process (GO:0044763) 0.652APOA1, ABCA1
response to chemical (GO:0042221) 1.982APOA1, ABCA1
localization (GO:0051179) 1.42APOA1, ABCA1
single-organism localization (GO:1902578) 2.092APOA1, ABCA1
primary metabolic process (GO:0044238) 0.692APOA1, ABCA1
cellular metabolic process (GO:0044237) 0.692APOA1, ABCA1
alcohol metabolic process (GO:0006066) 4.22APOA1, ABCA1
cholesterol efflux (GO:0033344) 6.472APOA1, ABCA1
organophosphate ester transport (GO:0015748) 5.332APOA1, ABCA1
negative regulation of cellular process (GO:0048523) 1.412APOA1, ABCA1
positive regulation of cellular process (GO:0048522) 1.32APOA1, ABCA1

NET-GE enrichment

Term New enriched termICP valueGenes
plasma lipoprotein particle assembly (GO:0034377) -6.840.0APOA1, ABCA1
sterol biosynthetic process (GO:0016126) NEW5.970.012APOA1, ABCA1
sterol transport (GO:0015918) -5.840.021APOA1, ABCA1
organic hydroxy compound transport (GO:0015850) -4.960.014APOA1, ABCA1
phospholipid transport (GO:0015914) -5.670.018APOA1, ABCA1
regulation of Rho protein signal transduction (GO:0035023) -5.020.015APOA1, ABCA1
regulation of Ras protein signal transduction (GO:0046578) -4.490.018APOA1, ABCA1
reverse cholesterol transport (GO:0043691) -6.840.0APOA1, ABCA1
positive regulation of Rho protein signal transduction (GO:0035025) NEW7.160.001APOA1, ABCA1
lipoprotein metabolic process (GO:0042157) -5.820.003APOA1, ABCA1
cholesterol homeostasis (GO:0042632) -5.60.005APOA1, ABCA1
plasma lipoprotein particle organization (GO:0071827) -6.230.001APOA1, ABCA1
phospholipid homeostasis (GO:0055091) -7.530.0APOA1, ABCA1
protein-lipid complex subunit organization (GO:0071825) -6.150.019APOA1, ABCA1
response to cholesterol (GO:0070723) NEW6.680.005APOA1, ABCA1
positive regulation of cAMP biosynthetic process (GO:0030819) NEW5.350.04APOA1, ABCA1
positive regulation of substrate adhesion-dependent cell spreading (GO:1900026) NEW6.40.006APOA1, ABCA1
regulation of cholesterol transport (GO:0032374) -6.090.012APOA1, ABCA1
regulation of substrate adhesion-dependent cell spreading (GO:1900024) NEW5.990.011APOA1, ABCA1
regulation of sterol transport (GO:0032371) -6.090.012APOA1, ABCA1
sterol homeostasis (GO:0055092) -5.60.005APOA1, ABCA1
negative regulation of cytokine-mediated signaling pathway (GO:0001960) NEW6.070.02APOA1, ABCA1
cholesterol transport (GO:0030301) -5.880.021APOA1, ABCA1
phospholipid efflux (GO:0033700) -7.090.001APOA1, ABCA1
cellular response to sterol (GO:0036315) NEW7.020.003APOA1, ABCA1
protein oxidation (GO:0018158) NEW7.940.0APOA1, ABCA1
sterol metabolic process (GO:0016125) -4.920.021APOA1, ABCA1
protein-lipid complex assembly (GO:0065005) -6.680.0APOA1, ABCA1
macromolecular complex remodeling (GO:0034367) NEW6.550.007APOA1, ABCA1
protein-lipid complex remodeling (GO:0034368) NEW6.550.007APOA1, ABCA1
plasma lipoprotein particle remodeling (GO:0034369) NEW6.550.007APOA1, ABCA1
response to nutrient (GO:0007584) -4.490.04APOA1, ABCA1
cellular response to cholesterol (GO:0071397) NEW7.240.002APOA1, ABCA1
lipid homeostasis (GO:0055088) -5.00.013APOA1, ABCA1
vitamin biosynthetic process (GO:0009110) NEW7.020.006APOA1, ABCA1
positive regulation of small GTPase mediated signal transduction (GO:0051057) NEW6.040.024APOA1, ABCA1
anion homeostasis (GO:0055081) NEW6.680.002APOA1, ABCA1
regulation of Cdc42 protein signal transduction (GO:0032489) -8.340.0APOA1, ABCA1
response to sterol (GO:0036314) NEW6.550.007APOA1, ABCA1
negative regulation of response to cytokine stimulus (GO:0060761) NEW5.970.027APOA1, ABCA1
regulation of cholesterol efflux (GO:0010874) NEW6.730.003APOA1, ABCA1
cholesterol metabolic process (GO:0008203) -5.030.017APOA1, ABCA1
negative regulation of cytokine secretion (GO:0050710) NEW5.920.025APOA1, ABCA1
regulation of lipid transport (GO:0032368) -5.210.01APOA1, ABCA1
negative regulation of lipid transport (GO:0032369) NEW6.430.007APOA1, ABCA1
high-density lipoprotein particle assembly (GO:0034380) -7.650.0APOA1, ABCA1
fat-soluble vitamin biosynthetic process (GO:0042362) NEW7.940.002APOA1, ABCA1
cholesterol efflux (GO:0033344) -6.470.001APOA1, ABCA1
negative regulation of tumor necrosis factor production (GO:0032720) NEW5.990.026APOA1, ABCA1
organophosphate ester transport (GO:0015748) -5.330.048APOA1, ABCA1
endothelial cell proliferation (GO:0001935) NEW6.550.009APOA1, ABCA1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
plasma lipoprotein particle (GO:0034358) 6.162APOA1, ABCA1
endocytic vesicle (GO:0030139) 5.042APOA1, ABCA1
intracellular organelle (GO:0043229) 0.512APOA1, ABCA1
lipoprotein particle (GO:1990777) 6.162APOA1, ABCA1
membrane-bounded organelle (GO:0043227) 0.472APOA1, ABCA1
organelle (GO:0043226) 0.42APOA1, ABCA1
vesicle (GO:0031982) 1.642APOA1, ABCA1
cytoplasmic, membrane-bounded vesicle (GO:0016023) 3.122APOA1, ABCA1
cytoplasmic vesicle (GO:0031410) 2.872APOA1, ABCA1
membrane (GO:0016020) 0.682APOA1, ABCA1
membrane-bounded vesicle (GO:0031988) 1.712APOA1, ABCA1
endoplasmic reticulum part (GO:0044432) 2.732APOA1, ABCA1
high-density lipoprotein particle (GO:0034364) 6.542APOA1, ABCA1
cell surface (GO:0009986) 3.442APOA1, ABCA1
intracellular vesicle (GO:0097708) 2.862APOA1, ABCA1
plasma membrane (GO:0005886) 1.392APOA1, ABCA1
protein-lipid complex (GO:0032994) 6.112APOA1, ABCA1
macromolecular complex (GO:0032991) 1.352APOA1, ABCA1
intracellular membrane-bounded organelle (GO:0043231) 0.62APOA1, ABCA1
cell part (GO:0044464) 0.112APOA1, ABCA1
intracellular organelle part (GO:0044446) 0.812APOA1, ABCA1
cytoplasmic part (GO:0044444) 0.822APOA1, ABCA1
intracellular part (GO:0044424) 0.282APOA1, ABCA1
extracellular region part (GO:0044421) 1.572APOA1, ABCA1
organelle part (GO:0044422) 0.792APOA1, ABCA1

NET-GE enrichment

Term New enriched termICP valueGenes
endocytic vesicle (GO:0030139) -5.040.025APOA1, ABCA1