Disease table of AMYLOIDOSIS, FAMILIAL VISCERAL OMIM ID: 105200

Gene-disease associations table

GeneAssociated with AMYLOIDOSIS, FAMILIAL VISCERAL inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
B2MOMIMHGNC link15q21.12105200, 241600
APOA1OMIM, HUMSAVARHGNC link11q23.33205400, 105200, 604091
LYZOMIM, HUMSAVARHGNC link12q151105200
FGAOMIM, HUMSAVARHGNC link4q31.33202400, 105200, 616004

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC12APOA1, LYZ
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
B2MYES3NFKB1, USF1, USF20
APOA1YES4SP1, GATA6, FOXA2, HNF4A0
LYZYES1SP10
FGAYES1TFCP20
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
APOA1LYZNo1CLU
APOA1FGAYes7FGA, FN1, DDX19B, ALB, APOA1, MIS12, ALDH2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
B2MAPOA1Yesreaction, binding22PRL, VCAM1, LYZ, APOA4, APP, FGA, IAPP, SAR1B, CST3, GSN, MFGE8, SNCA, SAA1, LTF, JUN, NPPA, ITM2B, SEMG1, TGFBI, TTR, CALR, ODAM
B2MLYZYesreaction, binding19FGA, IAPP, ITM2B, APOA4, SEMG1, PRL, CST3, GSN, APOA1, ODAM, TTR, LTF, MFGE8, SAA1, NPPA, UBC, SNCA, TGFBI, APP
B2MFGAYesreaction, binding18IAPP, ITM2B, APOA4, SEMG1, LTF, GSN, CST3, NPPA, LYZ, PRL, TTR, TGFBI, MFGE8, SAA1, ODAM, APOA1, SNCA, APP
APOA1LYZYesreaction, binding18FGA, IAPP, ITM2B, APOA4, SEMG1, PRL, GSN, CST3, NPPA, B2M, TTR, LTF, MFGE8, SAA1, ODAM, SNCA, TGFBI, APP
APOA1FGAYesreaction, binding19IAPP, GSN, ITM2B, APOA4, SEMG1, LTF, MIS12, CST3, NPPA, B2M, TTR, PRL, MFGE8, SAA1, ODAM, SNCA, LYZ, TGFBI, APP
LYZFGAYesreaction, binding18IAPP, ITM2B, APOA4, SEMG1, PRL, GSN, CST3, NPPA, B2M, TTR, LTF, MFGE8, SAA1, ODAM, APOA1, SNCA, TGFBI, APP

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: NET-GE enrichment (no shared terms)

NET-GE enrichment

Term New enriched termICP valueGenes
Salivary secretion (hsa04970) NEW6.230.002APOA1, B2M, LYZ
Infectious diseases: BacterialNEW3.760.033FGA, APOA1, B2M, LYZ
Natural killer cell mediated cytotoxicity (hsa04650) NEW5.530.007APOA1, B2M, LYZ
Digestive systemNEW4.120.012FGA, APOA1, B2M, LYZ
Tuberculosis (hsa05152) NEW5.170.038FGA, APOA1, B2M
Measles (hsa05162) NEW5.60.009APOA1, B2M, LYZ
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
AmyloidsR-HSA-9772257.374FGA, APOA1, B2M, LYZ
DiseaseR-HSA-16436853.334APOA1, FGA, B2M, LYZ
Platelet degranulation R-HSA-1146086.682APOA1, FGA
Innate Immune SystemR-HSA-1682493.172FGA, B2M
Platelet activation, signaling and aggregationR-HSA-760025.152APOA1, FGA
Immune SystemR-HSA-1682562.372FGA, B2M
Response to elevated platelet cytosolic Ca2+R-HSA-760056.592APOA1, FGA
Cytokine Signaling in Immune systemR-HSA-12802153.742FGA, B2M
DAP12 interactionsR-HSA-21721274.562FGA, B2M
DAP12 signalingR-HSA-24244914.642FGA, B2M
HemostasisR-HSA-1095823.982APOA1, FGA
Signal TransductionR-HSA-1625821.782FGA, APOA1

NET-GE enrichment

Term New enriched termICP valueGenes
Common Pathway of Fibrin Clot Formation (R-HSA-140875) NEW8.520.012FGA, B2M
Formation of Fibrin Clot (Clotting Cascade) (R-HSA-140877) NEW7.70.034FGA, B2M
Amyloids (R-HSA-977225) -7.370.0FGA, APOA1, B2M, LYZ
Disease (R-HSA-1643685) -3.330.011APOA1, FGA, B2M, LYZ
Signalling by NGF (R-HSA-166520) NEW4.230.022FGA, APOA1, B2M, LYZ
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.184FGA, APOA1, B2M, LYZ
protein binding (GO:0005515) 0.464FGA, APOA1, B2M, LYZ
identical protein binding (GO:0042802) 2.633APOA1, B2M, LYZ
cation binding (GO:0043169) 1.42APOA1, FGA
receptor binding (GO:0005102) 2.432APOA1, FGA
ion binding (GO:0043167) 1.362FGA, APOA1

NET-GE enrichment

Term New enriched termICP valueGenes
sulfur compound binding (GO:1901681) NEW4.320.037FGA, APOA1, B2M
phospholipid transporter activity (GO:0005548) NEW5.870.016APOA1, B2M
serine-type endopeptidase inhibitor activity (GO:0004867) NEW5.160.002FGA, APOA1, B2M
protein heterodimerization activity (GO:0046982) NEW3.640.008FGA, APOA1, B2M, LYZ
beta-amyloid binding (GO:0001540) NEW6.210.017APOA1, B2M
endopeptidase inhibitor activity (GO:0004866) NEW4.60.014FGA, APOA1, B2M
alcohol binding (GO:0043178) NEW5.530.002FGA, APOA1, B2M
endopeptidase regulator activity (GO:0061135) NEW4.570.016APOA1, FGA, B2M
peptidase regulator activity (GO:0061134) NEW4.370.0FGA, APOA1, B2M, LYZ
glycosaminoglycan binding (GO:0005539) NEW4.420.029FGA, APOA1, B2M
peptidase inhibitor activity (GO:0030414) NEW4.550.015APOA1, FGA, B2M
cell adhesion molecule binding (GO:0050839) NEW4.50.013FGA, B2M, LYZ
heparin binding (GO:0008201) NEW4.680.013FGA, APOA1, B2M
identical protein binding (GO:0042802) -2.630.036APOA1, B2M, LYZ
protein homodimerization activity (GO:0042803) NEW3.160.046APOA1, FGA, B2M, LYZ
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular protein metabolic process (GO:0044267) 1.634APOA1, FGA, B2M, LYZ
response to external stimulus (GO:0009605) 2.554APOA1, FGA, B2M, LYZ
cellular macromolecule metabolic process (GO:0044260) 0.934FGA, APOA1, B2M, LYZ
primary metabolic process (GO:0044238) 0.694APOA1, FGA, B2M, LYZ
protein metabolic process (GO:0019538) 1.454FGA, APOA1, B2M, LYZ
response to stimulus (GO:0050896) 1.224APOA1, FGA, B2M, LYZ
cellular process (GO:0009987) 0.264FGA, APOA1, B2M, LYZ
cellular metabolic process (GO:0044237) 0.694FGA, APOA1, B2M, LYZ
macromolecule metabolic process (GO:0043170) 0.834FGA, APOA1, B2M, LYZ
organic substance metabolic process (GO:0071704) 0.634APOA1, FGA, B2M, LYZ
response to stress (GO:0006950) 1.84APOA1, FGA, B2M, LYZ
biological regulation (GO:0065007) 0.394FGA, APOA1, B2M, LYZ
metabolic process (GO:0008152) 0.584FGA, APOA1, B2M, LYZ
regulation of biological quality (GO:0065008) 1.684APOA1, FGA, B2M, LYZ
response to bacterium (GO:0009617) 4.183FGA, B2M, LYZ
regulation of response to external stimulus (GO:0032101) 3.063APOA1, FGA, B2M
regulation of transport (GO:0051049) 2.243FGA, APOA1, B2M
positive regulation of response to stimulus (GO:0048584) 2.183FGA, APOA1, B2M
regulation of response to stimulus (GO:0048583) 1.543FGA, APOA1, B2M
regulation of cellular component organization (GO:0051128) 2.013FGA, APOA1, B2M
homeostatic process (GO:0042592) 2.613APOA1, B2M, LYZ
signal transduction (GO:0007165) 1.283APOA1, FGA, B2M
regulation of biological process (GO:0050789) 0.453APOA1, FGA, B2M
single-organism process (GO:0044699) 0.483FGA, APOA1, B2M
cellular response to stimulus (GO:0051716) 1.973APOA1, FGA, B2M
response to external biotic stimulus (GO:0043207) 3.133FGA, B2M, LYZ
negative regulation of multicellular organismal process (GO:0051241) 2.843APOA1, FGA, B2M
regulation of cell development (GO:0060284) 3.013APOA1, FGA, B2M
positive regulation of biological process (GO:0048518) 1.23APOA1, FGA, B2M
negative regulation of biological process (GO:0048519) 1.333APOA1, FGA, B2M
positive regulation of cellular component organization (GO:0051130) 2.683FGA, APOA1, B2M
regulation of developmental process (GO:0050793) 2.13APOA1, FGA, B2M
regulation of cellular process (GO:0050794) 0.53APOA1, FGA, B2M
defense response (GO:0006952) 2.783FGA, B2M, LYZ
regulation of cell differentiation (GO:0045595) 2.423FGA, APOA1, B2M
defense response to other organism (GO:0098542) 3.753FGA, B2M, LYZ
regulation of multicellular organismal process (GO:0051239) 1.873APOA1, FGA, B2M
response to chemical (GO:0042221) 1.983APOA1, FGA, B2M
regulation of localization (GO:0032879) 1.943FGA, APOA1, B2M
response to other organism (GO:0051707) 3.483FGA, B2M, LYZ
multi-organism process (GO:0051704) 2.653FGA, B2M, LYZ
response to biotic stimulus (GO:0009607) 3.093FGA, B2M, LYZ
regulation of response to stress (GO:0080134) 2.533APOA1, FGA, B2M
defense response to bacterium (GO:0042742) 4.313FGA, B2M, LYZ
single-organism cellular process (GO:0044763) 0.653FGA, APOA1, B2M
negative regulation of cellular process (GO:0048523) 1.413APOA1, FGA, B2M
positive regulation of cellular process (GO:0048522) 1.33FGA, APOA1, B2M
regulation of heterotypic cell-cell adhesion (GO:0034114) 6.842FGA, APOA1
regulation of phosphate metabolic process (GO:0019220) 2.352APOA1, FGA
regulation of primary metabolic process (GO:0080090) 1.082FGA, APOA1
regulation of secretion (GO:0051046) 3.22APOA1, FGA
anatomical structure homeostasis (GO:0060249) 4.252B2M, LYZ
negative regulation of response to stimulus (GO:0048585) 2.522APOA1, FGA
cell surface receptor signaling pathway (GO:0007166) 2.092APOA1, B2M
regulation of production of molecular mediator of immune response (GO:0002700) 5.12APOA1, B2M
cellular component organization or biogenesis (GO:0071840) 1.222FGA, APOA1
regulation of metabolic process (GO:0019222) 1.022FGA, APOA1
negative regulation of signal transduction (GO:0009968) 2.752FGA, APOA1
positive regulation of cell adhesion (GO:0045785) 3.792APOA1, FGA
regulation of signal transduction (GO:0009966) 1.842APOA1, FGA
positive regulation of signal transduction (GO:0009967) 2.52APOA1, FGA
antibacterial humoral response (GO:0019731) 6.022FGA, B2M
animal organ development (GO:0048513) 2.532APOA1, FGA
positive regulation of molecular function (GO:0044093) 2.232APOA1, B2M
negative regulation of molecular function (GO:0044092) 2.742APOA1, B2M
organ regeneration (GO:0031100) 5.32FGA, APOA1
regulation of macromolecule metabolic process (GO:0060255) 1.082APOA1, FGA
regulation of cellular protein metabolic process (GO:0032268) 1.992FGA, APOA1
cell adhesion (GO:0007155) 2.822FGA, B2M
response to metal ion (GO:0010038) 3.912FGA, B2M
response to inorganic substance (GO:0010035) 3.562FGA, B2M
response to organic substance (GO:0010033) 2.22FGA, B2M
regulation of phosphorylation (GO:0042325) 2.52APOA1, FGA
vesicle-mediated transport (GO:0016192) 2.722FGA, APOA1
single-multicellular organism process (GO:0044707) 1.782APOA1, FGA
chemical homeostasis (GO:0048878) 2.972APOA1, B2M
immune system process (GO:0002376) 2.292FGA, B2M
negative regulation of cell communication (GO:0010648) 2.662FGA, APOA1
regulation of cell morphogenesis (GO:0022604) 3.42APOA1, FGA
cellular component assembly (GO:0022607) 2.142APOA1, FGA
positive regulation of metabolic process (GO:0009893) 1.742APOA1, FGA
regulation of anatomical structure morphogenesis (GO:0022603) 2.792APOA1, FGA
secretion by cell (GO:0032940) 3.592FGA, APOA1
regulation of protein transport (GO:0051223) 3.122FGA, APOA1
regulation of protein secretion (GO:0050708) 3.772APOA1, FGA
exocytosis (GO:0006887) 4.112FGA, APOA1
cellular component organization (GO:0016043) 1.242FGA, APOA1
regulated exocytosis (GO:0045055) 4.442FGA, APOA1
macromolecular complex assembly (GO:0065003) 2.552APOA1, FGA
regulation of immune system process (GO:0002682) 2.52APOA1, B2M
regulation of defense response (GO:0031347) 3.112APOA1, B2M
regulation of molecular function (GO:0065009) 1.782APOA1, B2M
regulation of establishment of protein localization (GO:0070201) 3.022FGA, APOA1
single organism cell adhesion (GO:0098602) 3.632FGA, B2M
cell-cell adhesion (GO:0098609) 3.342FGA, B2M
transport (GO:0006810) 1.512APOA1, FGA
cell activation (GO:0001775) 3.472FGA, B2M
inflammatory response (GO:0006954) 3.642FGA, LYZ
immune response (GO:0006955) 2.862FGA, B2M
positive regulation of intracellular signal transduction (GO:1902533) 2.952APOA1, FGA
regulation of intracellular signal transduction (GO:1902531) 2.312FGA, APOA1
regulation of phosphorus metabolic process (GO:0051174) 2.352APOA1, FGA
secretion (GO:0046903) 3.382APOA1, FGA
regulation of immune effector process (GO:0002697) 3.712APOA1, B2M
positive regulation of multicellular organismal process (GO:0051240) 2.492FGA, B2M
negative regulation of response to external stimulus (GO:0032102) 4.182APOA1, FGA
regeneration (GO:0031099) 4.72FGA, APOA1
regulation of cell adhesion (GO:0030155) 3.272FGA, APOA1
negative regulation of cellular component organization (GO:0051129) 3.352APOA1, B2M
positive regulation of signaling (GO:0023056) 2.412APOA1, FGA
negative regulation of signaling (GO:0023057) 2.652APOA1, FGA
regulation of secretion by cell (GO:1903530) 3.282FGA, APOA1
cellular response to chemical stimulus (GO:0070887) 2.572FGA, B2M
regulation of signaling (GO:0023051) 1.722FGA, APOA1
positive regulation of cell communication (GO:0010647) 2.412FGA, APOA1
regulation of cell communication (GO:0010646) 1.732APOA1, FGA
regulation of protein localization (GO:0032880) 2.882APOA1, FGA
humoral immune response (GO:0006959) 4.592FGA, B2M
regulation of system process (GO:0044057) 3.532APOA1, FGA
positive regulation of substrate adhesion-dependent cell spreading (GO:1900026) 6.42APOA1, FGA
regulation of substrate adhesion-dependent cell spreading (GO:1900024) 5.992APOA1, FGA
regulation of protein metabolic process (GO:0051246) 1.932APOA1, FGA
regulation of cell morphogenesis involved in differentiation (GO:0010769) 3.912FGA, APOA1
regulation of protein modification process (GO:0031399) 2.322FGA, APOA1
biological adhesion (GO:0022610) 2.812FGA, B2M
developmental process (GO:0032502) 1.362APOA1, FGA
multicellular organismal process (GO:0032501) 1.452APOA1, FGA
positive regulation of cell development (GO:0010720) 3.572APOA1, FGA
regulation of vesicle-mediated transport (GO:0060627) 3.632FGA, B2M
positive regulation of cell differentiation (GO:0045597) 3.012APOA1, FGA
tissue homeostasis (GO:0001894) 4.782B2M, LYZ
retina homeostasis (GO:0001895) 6.072B2M, LYZ
regulation of immune response (GO:0050776) 2.982APOA1, B2M
positive regulation of developmental process (GO:0051094) 2.772APOA1, FGA
response to drug (GO:0042493) 3.712APOA1, B2M
regulation of cytokine production (GO:0001817) 3.42APOA1, B2M
positive regulation of cell morphogenesis involved in differentiation (GO:0010770) 4.652APOA1, FGA
gland development (GO:0048732) 4.152FGA, APOA1
single organismal cell-cell adhesion (GO:0016337) 3.692FGA, B2M
macromolecular complex subunit organization (GO:0043933) 2.142FGA, APOA1
positive regulation of cellular metabolic process (GO:0031325) 1.812FGA, APOA1
regulation of cellular metabolic process (GO:0031323) 1.072APOA1, FGA
regulation of cell-cell adhesion (GO:0022407) 3.792FGA, APOA1
response to lipid (GO:0033993) 3.112FGA, B2M
platelet degranulation (GO:0002576) 5.122FGA, APOA1
positive regulation of transport (GO:0051050) 2.92FGA, B2M
cellular response to organic substance (GO:0071310) 2.782FGA, B2M
regulation of cell-substrate adhesion (GO:0010810) 4.562APOA1, FGA
positive regulation of cell-substrate adhesion (GO:0010811) 5.112APOA1, FGA
innate immune response (GO:0045087) 3.552FGA, B2M
single-organism developmental process (GO:0044767) 1.492APOA1, FGA
single-organism transport (GO:0044765) 2.182FGA, APOA1
regulation of cytokine production involved in immune response (GO:0002718) 5.692APOA1, B2M
antimicrobial humoral response (GO:0019730) 5.922FGA, B2M
localization (GO:0051179) 1.42APOA1, FGA
single-organism localization (GO:1902578) 2.092APOA1, FGA
response to oxygen-containing compound (GO:1901700) 2.572FGA, B2M
establishment of localization (GO:0051234) 1.482FGA, APOA1
anatomical structure development (GO:0048856) 1.582FGA, APOA1
regulation of multicellular organismal development (GO:2000026) 2.312APOA1, B2M
regulation of protein phosphorylation (GO:0001932) 2.572FGA, APOA1

NET-GE enrichment

Term New enriched termICP valueGenes
positive regulation of substrate adhesion-dependent cell spreading (GO:1900026) -6.40.004APOA1, FGA
regulation of heterotypic cell-cell adhesion (GO:0034114) -6.840.024FGA, APOA1
negative regulation of response to external stimulus (GO:0032102) -4.180.002APOA1, FGA, B2M, LYZ
positive regulation of secretion (GO:0051047) NEW3.850.01FGA, APOA1, B2M, LYZ
regulation of cell activation (GO:0050865) NEW3.530.044APOA1, FGA, B2M, LYZ
Sertoli cell development (GO:0060009) NEW6.960.018APOA1, B2M
positive regulation of hormone secretion (GO:0046887) NEW4.980.017FGA, APOA1, B2M
regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803) NEW5.840.017APOA1, LYZ
regulation of homeostatic process (GO:0032844) NEW3.650.014FGA, APOA1, B2M, LYZ
blood coagulation (GO:0007596) NEW4.520.04FGA, APOA1, B2M, LYZ
regulation of cell-cell adhesion (GO:0022407) -3.790.017FGA, APOA1, LYZ
leukocyte migration (GO:0050900) NEW4.190.001APOA1, FGA, B2M, LYZ
hydrogen peroxide catabolic process (GO:0042744) NEW6.780.032APOA1, B2M
regulation of lipid biosynthetic process (GO:0046890) NEW4.870.036APOA1, FGA, LYZ
positive regulation of cell death (GO:0010942) NEW3.320.045APOA1, FGA, B2M, LYZ
hemostasis (GO:0007599) NEW4.50.041FGA, APOA1, B2M, LYZ
positive regulation of protein transport (GO:0051222) NEW3.610.009FGA, APOA1, B2M, LYZ
negative regulation of cytokine secretion involved in immune response (GO:0002740) NEW7.940.002APOA1, B2M
cytolysis (GO:0019835) NEW6.640.0APOA1, B2M, LYZ
response to inorganic substance (GO:0010035) -3.560.024APOA1, FGA, B2M, LYZ
regulation of protein secretion (GO:0050708) -3.770.002APOA1, FGA, B2M, LYZ
regulation of leukocyte activation (GO:0002694) NEW3.60.031APOA1, FGA, B2M, LYZ
negative regulation of cholesterol transport (GO:0032375) NEW7.240.01APOA1, LYZ
response to other organism (GO:0051707) -3.480.033FGA, APOA1, B2M, LYZ
regulation of interleukin-1 beta secretion (GO:0050706) NEW6.360.048APOA1, LYZ
regulation of cytokine secretion (GO:0050707) NEW4.740.047APOA1, B2M, LYZ
regulation of cytoskeleton organization (GO:0051493) NEW3.720.019APOA1, FGA, B2M, LYZ
negative regulation of sterol transport (GO:0032372) NEW7.240.01APOA1, LYZ
positive regulation of apoptotic process (GO:0043065) NEW3.380.031APOA1, FGA, B2M, LYZ
positive regulation of peptide hormone secretion (GO:0090277) NEW5.260.007FGA, APOA1, B2M
extracellular structure organization (GO:0043062) NEW4.00.012APOA1, FGA, B2M, LYZ
innate immune response in mucosa (GO:0002227) NEW6.840.037APOA1, B2M
positive regulation of programmed cell death (GO:0043068) NEW3.380.032APOA1, FGA, B2M, LYZ
negative regulation of defense response (GO:0031348) NEW4.750.046APOA1, B2M, LYZ
single organism cell adhesion (GO:0098602) -3.630.006APOA1, FGA, B2M, LYZ
negative regulation of transport (GO:0051051) NEW3.60.029FGA, APOA1, B2M, LYZ
regulation of lipid metabolic process (GO:0019216) NEW4.080.003APOA1, FGA, B2M, LYZ
regulation of endopeptidase activity (GO:0052548) NEW3.80.017FGA, APOA1, B2M, LYZ
regulation of actin filament-based process (GO:0032970) NEW3.970.006APOA1, FGA, B2M, LYZ
regulation of vesicle-mediated transport (GO:0060627) -3.630.016FGA, APOA1, B2M, LYZ
response to calcium ion (GO:0051592) NEW4.980.018FGA, APOA1, B2M
coagulation (GO:0050817) NEW4.510.04APOA1, FGA, B2M, LYZ
defense response to other organism (GO:0098542) -3.750.007APOA1, FGA, B2M, LYZ
inflammatory response (GO:0006954) -3.640.026APOA1, FGA, B2M, LYZ
regulation of cytokine secretion involved in immune response (GO:0002739) NEW7.330.008APOA1, B2M
single organismal cell-cell adhesion (GO:0016337) -3.690.005FGA, APOA1, B2M, LYZ
retina homeostasis (GO:0001895) -6.070.013B2M, LYZ
leukocyte migration involved in inflammatory response (GO:0002523) NEW7.240.018APOA1, LYZ
leukocyte cell-cell adhesion (GO:0007159) NEW4.260.0APOA1, FGA, B2M, LYZ
positive regulation of ERK1 and ERK2 cascade (GO:0070374) NEW4.560.026APOA1, FGA, LYZ
regulation of lipid transport (GO:0032368) NEW5.210.0APOA1, FGA, B2M, LYZ
leukocyte activation (GO:0045321) NEW3.760.033FGA, APOA1, B2M, LYZ
negative regulation of multicellular organismal process (GO:0051241) -2.840.041APOA1, FGA, B2M, LYZ
integrin-mediated signaling pathway (GO:0007229) NEW5.170.0FGA, APOA1, B2M, LYZ
regulation of protein stability (GO:0031647) NEW4.330.039APOA1, B2M, LYZ
positive regulation of immune response (GO:0050778) NEW3.40.042FGA, APOA1, B2M, LYZ
positive regulation of peptide secretion (GO:0002793) NEW5.220.008APOA1, FGA, B2M
regulation of tumor necrosis factor production (GO:0032680) NEW5.130.016APOA1, FGA, B2M
extracellular matrix organization (GO:0030198) NEW4.010.012FGA, APOA1, B2M, LYZ
response to peptide (GO:1901652) NEW3.940.022APOA1, FGA, B2M, LYZ
negative regulation of cytokine production (GO:0001818) NEW4.40.001APOA1, FGA, B2M, LYZ
regulation of peptidase activity (GO:0052547) NEW3.750.02FGA, APOA1, B2M, LYZ
positive regulation of cell morphogenesis involved in differentiation (GO:0010770) -4.650.025APOA1, FGA
negative regulation of endocytosis (GO:0045806) NEW6.040.001APOA1, B2M, LYZ
regulation of substrate adhesion-dependent cell spreading (GO:1900024) -5.990.007APOA1, FGA
regulation of actin cytoskeleton organization (GO:0032956) NEW4.090.005FGA, APOA1, B2M, LYZ
organic hydroxy compound metabolic process (GO:1901615) NEW3.840.036FGA, APOA1, B2M, LYZ
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
extracellular vesicle (GO:1903561) 1.894FGA, APOA1, B2M, LYZ
extracellular organelle (GO:0043230) 1.894FGA, APOA1, B2M, LYZ
vesicle (GO:0031982) 1.644FGA, APOA1, B2M, LYZ
extracellular space (GO:0005615) 2.634FGA, APOA1, B2M, LYZ
organelle (GO:0043226) 0.44APOA1, FGA, B2M, LYZ
extracellular region (GO:0005576) 2.184FGA, APOA1, B2M, LYZ
membrane-bounded vesicle (GO:0031988) 1.714FGA, APOA1, B2M, LYZ
membrane-bounded organelle (GO:0043227) 0.474APOA1, FGA, B2M, LYZ
extracellular region part (GO:0044421) 1.574APOA1, FGA, B2M, LYZ
extracellular exosome (GO:0070062) 1.894APOA1, FGA, B2M, LYZ
intracellular organelle part (GO:0044446) 0.813FGA, APOA1, B2M
macromolecular complex (GO:0032991) 1.353APOA1, FGA, B2M
intracellular membrane-bounded organelle (GO:0043231) 0.63APOA1, FGA, B2M
organelle lumen (GO:0043233) 3.053APOA1, FGA, B2M
membrane (GO:0016020) 0.683FGA, APOA1, B2M
cell part (GO:0044464) 0.113APOA1, FGA, B2M
cytoplasmic part (GO:0044444) 0.823APOA1, FGA, B2M
membrane-enclosed lumen (GO:0031974) 3.053APOA1, FGA, B2M
cytoplasmic vesicle part (GO:0044433) 3.413FGA, APOA1, B2M
intracellular organelle lumen (GO:0070013) 3.053APOA1, FGA, B2M
intracellular organelle (GO:0043229) 0.513APOA1, FGA, B2M
plasma membrane (GO:0005886) 1.393FGA, APOA1, B2M
intracellular part (GO:0044424) 0.283APOA1, FGA, B2M
organelle part (GO:0044422) 0.793FGA, APOA1, B2M
protein complex (GO:0043234) 1.512FGA, B2M
external side of plasma membrane (GO:0009897) 4.462FGA, B2M
vesicle lumen (GO:0031983) 5.172APOA1, FGA
cytoplasmic, membrane-bounded vesicle (GO:0016023) 3.122FGA, APOA1
cytoplasmic vesicle (GO:0031410) 2.872FGA, APOA1
cell surface (GO:0009986) 3.442APOA1, FGA
cytoplasmic membrane-bounded vesicle lumen (GO:0060205) 5.192APOA1, FGA
endoplasmic reticulum lumen (GO:0005788) 4.52APOA1, B2M
cytoplasm (GO:0005737) 1.012FGA, B2M
endoplasmic reticulum part (GO:0044432) 2.732APOA1, B2M
side of membrane (GO:0098552) 4.222FGA, B2M
blood microparticle (GO:0072562) 4.882FGA, APOA1
secretory granule lumen (GO:0034774) 5.382FGA, APOA1
membrane part (GO:0044425) 0.952FGA, B2M
plasma membrane part (GO:0044459) 1.952FGA, B2M
intracellular vesicle (GO:0097708) 2.862APOA1, FGA

NET-GE enrichment

Term New enriched termICP valueGenes
external side of plasma membrane (GO:0009897) -4.460.0FGA, APOA1, B2M, LYZ
lytic vacuole (GO:0000323) NEW3.890.03APOA1, FGA, B2M
endoplasmic reticulum (GO:0005783) NEW2.560.04APOA1, FGA, B2M, LYZ
cytoplasmic membrane-bounded vesicle lumen (GO:0060205) -5.190.008APOA1, FGA
membrane-enclosed lumen (GO:0031974) -3.050.016APOA1, FGA, B2M
vacuole (GO:0005773) NEW2.920.042FGA, APOA1, B2M
vesicle lumen (GO:0031983) -5.170.008APOA1, FGA
extracellular space (GO:0005615) -2.630.001FGA, APOA1, B2M, LYZ
cytoplasmic membrane-bounded vesicle (GO:0016023) -3.120.023APOA1, FGA, B2M, LYZ
cytoplasmic vesicle (GO:0031410) -2.870.04FGA, APOA1, B2M, LYZ
blood microparticle (GO:0072562) -4.880.0FGA, APOA1, B2M, LYZ
vacuolar membrane (GO:0005774) NEW3.450.03FGA, APOA1, B2M
cytoplasmic vesicle part (GO:0044433) -3.410.009FGA, APOA1, B2M
cell surface (GO:0009986) -3.440.008APOA1, FGA, B2M, LYZ
side of membrane (GO:0098552) -4.220.001FGA, APOA1, B2M, LYZ
endoplasmic reticulum lumen (GO:0005788) -4.50.011APOA1, FGA, B2M
secretory granule lumen (GO:0034774) -5.380.005FGA, APOA1
extracellular vesicular exosome (GO:0070062) -1.890.033APOA1, FGA, B2M, LYZ
receptor complex (GO:0043235) NEW4.010.042FGA, B2M, LYZ
extracellular organelle (GO:0043230) -1.890.033FGA, APOA1, B2M, LYZ
organelle lumen (GO:0043233) -3.050.012APOA1, FGA, B2M
extracellular membrane-bounded organelle (GO:0065010) NEW8.70.033APOA1, FGA, B2M, LYZ
lysosome (GO:0005764) NEW3.890.029APOA1, FGA, B2M
lysosomal membrane (GO:0005765) NEW4.190.021APOA1, FGA, B2M
extracellular region (GO:0005576) -2.180.004FGA, APOA1, B2M, LYZ
extracellular matrix part (GO:0044420) NEW4.970.0FGA, APOA1, B2M, LYZ