Disease table of PULMONARY DISEASE, CHRONIC OBSTRUCTIVE OMIM ID: 606963

Gene-disease associations table

GeneAssociated with PULMONARY DISEASE, CHRONIC OBSTRUCTIVE inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
SERPINA1OMIMHGNC link14q32.133309548, 613490, 606963
HMOX1OMIMHGNC link22q12.32606963, 614034
MMP1OMIMHGNC link11q22.23606963, 610504, 226600

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
ETS1NO90PF4, ITGB3, TP53, TBXAS1, GABRE, PTHLH, TNFSF14, CD14, IGFBP1, BAX, SLC26A3, IL2, MGAT5, VWF, HPGD, CA9, MMP3, MMP9, CSF3R, IL2RB, TERT, THY1, FLT1, FGFBP1, CSF2, MYB, FLI1, ANGPT2, GP6, EGR1, TMEM158, CSNK2B, ERG, SQSTM1, WAS, F13A1, CD8A, MMP1, TGFBR2, ABCB1, ATXN2, NDRG1, SPRY2, HSPB8, BMP4, PRL, TBXA2R, CDKN2A, CHUK, NKX3-1, TAF12, MUC4, HSPE1, TRB, AXIN1, BRCA1, LCK, MMP10, SPP1, RHOC, ICAM1, ANPEP, CSNK2A1, IL5, CR1, HSPA6, HMOX1, CASP1, MDM2, PLAU, SNAI1, TFAP2A, CTSB, TRA, CXCR4, ECE1, SRD5A1, HSPA1L, DUSP6, CDKN1A, FOXD1, GRPR, CTGF, PARP1, TNC, HSPA8, IL3, COL1A1, MMP13, CD62MMP1, HMOX1
STAT3NO129IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP122MMP1, HMOX1
BACH1NO2MMP1, HMOX12MMP1, HMOX1
NFKB1NO306NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC62MMP1, HMOX1
RELANO302NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC62MMP1, HMOX1
FLI1NO18ID2, PHLDA1, TERT, FOXM1, GP9, MMP1, FLI1, MPL, EZH2, TGFBR2, ERG, IGFBP3, GATA1, IL10, HMOX1, CTGF, GP6, ITGA2B2MMP1, HMOX1
PPARGNO69BCL2L1, EGFR, PLIN2, TNFRSF11B, CPT1B, DEFB103A, NOTCH4, VLDLR, SAT1, TP53, DBI, CAV1, CIDEA, PDK2, SERPINE1, CFLAR, ATP2A2, STAT6, ICAM1, TXNIP, FABP4, PTGS2, JAG1, CCNE1, GDF15, CEBPA, KLF5, GK, APOBR, ERO1L, RETN, CD83, TG, AGER, CAT, CSF1, POU2F1, BCL2, REN, UGT1A9, CDKN1A, CLDN2, ERP44, RARB, ANGPTL4, ADIPOQ, SOCS7, PTEN, BAD, SLC2A4, FGF1, SLC9A1, CD36, ABCG2, MMP1, BRS3, NR1H3, TSHR, LIPE, SLC5A5, ACAT1, MMP9, APOB, HMOX1, CIITA, MYC, CCND1, KLF4, FASLG2MMP1, HMOX1
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
HMOX1YES18ETS1, STAT3, NFKB1, BACH1, PPARA, SMAD7, AR, TFAP2A, USF1, NFE2L2, CREB1, FLI1, RELA, SREBF1, ERG, PPARG, STAT1, USF20
MMP1YES24MAZ, RFWD2, TWIST1, FOSL1, NFKBIA, ETS2, FOS, PAX5, ETV4, BACH1, CITED2, ETV3, NR4A2, JUN, TP53, RELA, ZNF410, NFKB1, ETS1, STAT3, GATA3, FLI1, CEBPB, PPARG0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
SERPINA1HMOX1No2DERL1, DDX19B

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
SERPINA1HMOX1No-3UBC, IL6, VEGFA
SERPINA1MMP1No-7IGF1, IGF2, CEBPB, IL6, TIMP1, A2M, VEGFA
HMOX1MMP1No-16STAT3, MMP9, VEGFA, MAPK8, FOS, CXCL12, BDNF, IL6, TP53, FOSL1, JUN, CCL2, AKT1, MAPK14, PPARG, JUND

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
HemostasisR-HSA-1095823.982MMP1, SERPINA1

NET-GE enrichment

Term New enriched termICP valueGenes
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (R-HSA-381426) NEW8.590.004MMP1, SERPINA1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.183MMP1, HMOX1, SERPINA1
cation binding (GO:0043169) 1.42MMP1, HMOX1
hydrolase activity (GO:0016787) 1.92MMP1, HMOX1
enzyme binding (GO:0019899) 2.272HMOX1, SERPINA1
ion binding (GO:0043167) 1.362MMP1, HMOX1
catalytic activity (GO:0003824) 1.052MMP1, HMOX1
protein binding (GO:0005515) 0.462HMOX1, SERPINA1
metal ion binding (GO:0046872) 1.412MMP1, HMOX1
identical protein binding (GO:0042802) 2.632HMOX1, SERPINA1

NET-GE enrichment

Term New enriched termICP valueGenes
serine-type endopeptidase activity (GO:0004252) NEW4.40.002MMP1, HMOX1, SERPINA1
endopeptidase activity (GO:0004175) NEW3.630.043MMP1, HMOX1, SERPINA1
serine hydrolase activity (GO:0017171) NEW4.260.003MMP1, HMOX1, SERPINA1
enzyme inhibitor activity (GO:0004857) NEW3.780.037MMP1, HMOX1, SERPINA1
serine-type peptidase activity (GO:0008236) NEW4.270.003MMP1, HMOX1, SERPINA1
GO - biological process annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
multicellular organismal process (GO:0032501) 1.453MMP1, HMOX1, SERPINA1
single-multicellular organism process (GO:0044707) 1.783MMP1, HMOX1, SERPINA1
cellular process (GO:0009987) 0.263MMP1, HMOX1, SERPINA1
cellular component organization (GO:0016043) 1.243MMP1, HMOX1, SERPINA1
regulation of cellular process (GO:0050794) 0.53MMP1, HMOX1, SERPINA1
single-organism cellular process (GO:0044763) 0.653MMP1, HMOX1, SERPINA1
cellular component organization or biogenesis (GO:0071840) 1.223MMP1, HMOX1, SERPINA1
biological regulation (GO:0065007) 0.393MMP1, HMOX1, SERPINA1
regulation of biological process (GO:0050789) 0.453MMP1, HMOX1, SERPINA1
single-organism process (GO:0044699) 0.483MMP1, HMOX1, SERPINA1
cellular component assembly (GO:0022607) 2.142HMOX1, SERPINA1
regulation of primary metabolic process (GO:0080090) 1.082HMOX1, SERPINA1
regulation of metabolic process (GO:0019222) 1.022HMOX1, SERPINA1
macromolecular complex subunit organization (GO:0043933) 2.142HMOX1, SERPINA1
regulation of cellular metabolic process (GO:0031323) 1.072HMOX1, SERPINA1
single-organism catabolic process (GO:0044712) 3.212MMP1, HMOX1
single-organism metabolic process (GO:0044710) 1.632MMP1, HMOX1
protein complex subunit organization (GO:0071822) 2.62HMOX1, SERPINA1
regulation of protein metabolic process (GO:0051246) 1.932HMOX1, SERPINA1
macromolecular complex assembly (GO:0065003) 2.552HMOX1, SERPINA1
organic substance metabolic process (GO:0071704) 0.632MMP1, HMOX1
negative regulation of molecular function (GO:0044092) 2.742HMOX1, SERPINA1
positive regulation of biological process (GO:0048518) 1.22MMP1, HMOX1
negative regulation of biological process (GO:0048519) 1.332HMOX1, SERPINA1
regulation of molecular function (GO:0065009) 1.782HMOX1, SERPINA1
regulation of biological quality (GO:0065008) 1.682HMOX1, SERPINA1
regulation of macromolecule metabolic process (GO:0060255) 1.082HMOX1, SERPINA1
protein complex assembly (GO:0006461) 2.782HMOX1, SERPINA1
response to stress (GO:0006950) 1.82HMOX1, SERPINA1
metabolic process (GO:0008152) 0.582MMP1, HMOX1
catabolic process (GO:0009056) 2.382MMP1, HMOX1
response to stimulus (GO:0050896) 1.222HMOX1, SERPINA1
cellular metabolic process (GO:0044237) 0.692MMP1, HMOX1
immune system process (GO:0002376) 2.292MMP1, HMOX1
negative regulation of cellular process (GO:0048523) 1.412HMOX1, SERPINA1
positive regulation of cellular process (GO:0048522) 1.32MMP1, HMOX1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
extracellular region part (GO:0044421) 1.573MMP1, HMOX1, SERPINA1
intracellular membrane-bounded organelle (GO:0043231) 0.62HMOX1, SERPINA1
endoplasmic reticulum (GO:0005783) 2.562HMOX1, SERPINA1
membrane (GO:0016020) 0.682HMOX1, SERPINA1
cell part (GO:0044464) 0.112HMOX1, SERPINA1
cytoplasmic part (GO:0044444) 0.822HMOX1, SERPINA1
extracellular matrix (GO:0031012) 3.812MMP1, SERPINA1
intracellular organelle part (GO:0044446) 0.812HMOX1, SERPINA1
endoplasmic reticulum part (GO:0044432) 2.732HMOX1, SERPINA1
intracellular organelle (GO:0043229) 0.512HMOX1, SERPINA1
extracellular region (GO:0005576) 2.182MMP1, SERPINA1
proteinaceous extracellular matrix (GO:0005578) 4.012MMP1, SERPINA1
intracellular part (GO:0044424) 0.282HMOX1, SERPINA1
membrane-bounded organelle (GO:0043227) 0.472HMOX1, SERPINA1
organelle (GO:0043226) 0.42HMOX1, SERPINA1
organelle part (GO:0044422) 0.792HMOX1, SERPINA1
extracellular space (GO:0005615) 2.632HMOX1, SERPINA1

NET-GE enrichment

Term New enriched termICP valueGenes
secretory granule (GO:0030141) NEW4.340.003MMP1, HMOX1, SERPINA1
proteinaceous extracellular matrix (GO:0005578) -4.010.022MMP1, SERPINA1
extracellular matrix (GO:0031012) -3.810.008MMP1, HMOX1, SERPINA1