Disease table of HYPOGONADOTROPIC HYPOGONADISM WITH OR WITHOUT ANOSMIA OMIM ID: PS147950

Gene-disease associations table

GeneAssociated with HYPOGONADOTROPIC HYPOGONADISM WITH OR WITHOUT ANOSMIA inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
GNRHRClinVar, OMIM, HUMSAVARHGNC link4q13.21PS147950
SPRY4ClinVar, OMIM, HUMSAVARHGNC link5q31.31PS147950
FEZF1OMIM, HUMSAVARHGNC link7q31.321PS147950
CHD7ClinVar, OMIM, HUMSAVARHGNC link8q12.23214800, 608765, PS147950
FSHBClinVar, OMIM, HUMSAVARHGNC link11p14.11PS147950
TAC3OMIM, HUMSAVARHGNC link12q13.31PS147950
NSMFClinVar, OMIM, HUMSAVARHGNC link9q34.31PS147950
PROKR2ClinVar, OMIM, HUMSAVARHGNC link20p12.31PS147950
ANOS1ClinVar, OMIM, HUMSAVARHGNC linkXp22.311PS147950
DUSP6ClinVar, OMIM, HUMSAVARHGNC link12q21.331PS147950
FGF17ClinVar, OMIM, HUMSAVARHGNC link8p21.31PS147950
KISS1RClinVar, OMIM, HUMSAVARHGNC link19p13.32PS176400, PS147950
KISS1ClinVar, OMIM, HUMSAVARHGNC link1q32.11PS147950
LHBClinVar, OMIM, HUMSAVARHGNC link19q13.331PS147950
FLRT3ClinVar, OMIM, HUMSAVARHGNC link20p12.11PS147950
FGF8ClinVar, OMIM, HUMSAVARHGNC link10q24.321PS147950
TACR3ClinVar, OMIM, HUMSAVARHGNC link4q241PS147950
FGFR1ClinVar, OMIM, HUMSAVARHGNC link8p11.237166250, PS147950, 101600, 613001, PS190440, 615465, 123150
SEMA3AClinVar, OMIM, HUMSAVARHGNC link7q21.111PS147950
PROK2ClinVar, OMIM, HUMSAVARHGNC link3p131PS147950
WDR11ClinVar, OMIM, HUMSAVARHGNC link10q26.121PS147950
HS6ST1OMIM, HUMSAVARHGNC link2q14.31PS147950
GNRH1ClinVar, OMIMHGNC link8p21.21PS147950
IL17RDOMIM, HUMSAVARHGNC link3p14.31PS147950

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
8p212GNRH1, FGF17
20p122FLRT3, PROKR2
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
3p12PROK2, IL17RD
8p22GNRH1, FGF17
10q22WDR11, FGF8
20p12FLRT3, PROKR2
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
20p2FLRT3, PROKR2
10q2WDR11, FGF8
3p2PROK2, IL17RD
4q2TACR3, GNRHR
12q2TAC3, DUSP6
7q2SEMA3A, FEZF1
8p3FGFR1, FGF17, GNRH1
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
102WDR11, FGF8
122TAC3, DUSP6
202FLRT3, PROKR2
192KISS1R, LHB
32PROK2, IL17RD
42TACR3, GNRHR
72SEMA3A, FEZF1
84FGF17, FGFR1, CHD7, GNRH1
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC12KISS1, FGFR1
ARNO83UGT2B15, PTPN1, CDH11, AKR1C3, USP26, FOLH1, CCR2, CDK20, CDK6, PNRC1, ARG1, XIAP, VIM, ARG2, EGFR, CFLAR, ETV1, BSG, IGF1R, MUC1, WEE1, PTGS2, NKX3-1, AKT1, NRAS, CDH1, EP300, KLF5, ACTA1, CLK3, FN1, TNF, PRL, ERBB2, ERBB3, CRISP3, CTNNB1, PTEN, CRISP1, SERPINB5, TSC2, NAT1, CDKN1A, GREB1, SEPT7, IFI16, PIGR, KLK3, PC, STIM1, SRD5A3, TCF7L2, JUN, TMPRSS2, RELA, TJP1, BTG1, VEGFA, NFKB1, HMMR, FKBP5, KLK4, CRH, CDH2, BTG2, TGFA, SESN1, CDC6, TH, ALDH1A3, KISS1, KISS1R, PEBP1, KLK2, ATAD2, HMOX1, TSC1, WNT7B, PEG10, TRPS1, CCND1, PIP, FOXA12KISS1, KISS1R
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
FSHBYES3LHX3, SMAD3, SMAD20
TAC3YES2REST, ESR10
DUSP6YES2ETS1, ETS20
KISS1RYES1AR0
KISS1YES4SP1, MED23, AR, TFAP2A0
LHBYES5SF1, NR5A1, PITX1, EGR1, FOXO10
FGF8YES2NFKB1, RELA0
FGFR1YES4SP1, RB1, KLF10, E2F10
GNRH1YES4POU3F2, NF1, POU3F1, POU2F10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
SPRY4WDR11No1TMEM17
KISS1RKISS1Yes0
FGF8FGFR1Yes1FGFR1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
GNRHRFSHBNo-2GNAS, GNB1
GNRHRTAC3Yesreaction, binding121P2RY6, GPR17, KISS1, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, ANXA1, NTS, EDN3, CYSLTR1, EDN1, NPS, GCGR, SAA1, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GRM1, EDNRB, QRFP, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, PROK2, TAC1, GCG, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, TRH, GPR132, TACR1, ADRA1B, QRFPR, HCRTR2, P2RY10, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, MLNR, CCKBR, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, BDKRB2, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, CHRM5, P2RY2, AVP, LTB4R2, PMCH, PROKR1, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, TACR3, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, HTR2A, ADRA1A, MCHR1, LPAR2, UTS2
GNRHRPROKR2Yesreaction, binding121P2RY6, GPR17, KISS1, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, QRFPR, NTS, EDN3, CYSLTR1, EDN1, NPS, GCGR, SAA1, AVP, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GRM1, EDNRB, CCKBR, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, PROK2, TAC1, TAC3, GCG, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, TRH, GPR132, TACR1, ADRA1B, ANXA1, HCRTR2, P2RY10, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, MLNR, QRFP, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, CHRM5, P2RY2, BDKRB2, LTB4R2, PMCH, PROKR1, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, TACR3, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, UTS2D, LPAR4, NMS, ADRA1D, HTR2A, ADRA1A, MCHR1, LPAR2, UTS2
GNRHRDUSP6No-1MAPK7
GNRHRKISS1RYesreaction, binding121P2RY6, GPR17, KISS1, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, GPRC6A, BDKRB2, EDN3, CYSLTR1, EDN1, NPS, CHRM5, SAA1, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GRM1, EDNRB, QRFP, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, PROK2, TAC1, TAC3, GCG, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, NTS, TRH, GPR132, TACR1, ADRA1B, ANXA1, HCRTR2, P2RY10, HRH1, EDNRA, GNG2, FPR2, TBXA2R, CCK, CCKBR, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, MLNR, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, GCGR, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, P2RY2, AVP, LTB4R2, PMCH, QRFPR, HTR2A, GRM5, NPSR1, KNG1, CCKAR, NTSR1, TACR3, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, PROKR1, ADRA1A, MCHR1, LPAR2, UTS2
GNRHRKISS1Yesactivation, binding121P2RY6, GPR17, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, ANXA1, NTS, EDN3, CYSLTR1, EDN1, NPS, CHRM5, SAA1, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GRM1, EDNRB, QRFP, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, PROK2, TAC1, TAC3, GCG, OPN4, FFAR3, AVP, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, TRH, GPR132, TACR1, ADRA1B, GPRC6A, HCRTR2, P2RY10, HRH1, EDNRA, GNG2, FPR2, TBXA2R, MLNR, CCKBR, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, NPFF, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, GCGR, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, P2RY2, BDKRB2, LTB4R2, PMCH, QRFPR, PROKR1, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, TACR3, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, HTR2A, ADRA1A, MCHR1, LPAR2, UTS2
GNRHRFGF8No-1EDN1
GNRHRTACR3Yesreaction, binding121P2RY6, GPR17, KISS1, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, ANXA1, NTS, EDN3, CYSLTR1, EDN1, NPS, GCGR, SAA1, AVP, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GRM1, EDNRB, QRFP, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, PROK2, TAC1, TAC3, GCG, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, TRH, GPR132, TACR1, ADRA1B, QRFPR, HCRTR2, P2RY10, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, MLNR, CCKBR, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, CHRM5, P2RY2, BDKRB2, LTB4R2, PMCH, PROKR1, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, HTR2A, ADRA1A, MCHR1, LPAR2, UTS2
GNRHRFGFR1No-1EDNRA
GNRHRPROK2Yesreaction, binding121P2RY6, GPR17, KISS1, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, QRFPR, UTS2, EDN3, CYSLTR1, EDN1, NPS, GCGR, SAA1, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GRM1, EDNRB, QRFP, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, TAC1, TAC3, GCG, OPN4, FFAR3, AVP, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, NTS, TRH, GPR132, TACR1, ADRA1B, ANXA1, HCRTR2, P2RY10, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, MLNR, CCKBR, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, NPFF, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, CHRM5, P2RY2, BDKRB2, LTB4R2, PMCH, HTR2A, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, TACR3, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, PROKR1, ADRA1A, MCHR1, LPAR2
GNRHRGNRH1Yesactivation, binding122P2RY6, GPR17, KISS1, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, ANXA1, NTS, EDN3, CYSLTR1, EDN1, NPS, CHRM5, SAA1, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GRM1, EDNRB, QRFP, OXT, GRP, BDKRB2, CASR, F2RL1, PROK2, TAC1, TAC3, GCG, OPN4, FFAR3, AVP, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, TRH, GPR132, TACR1, ADRA1B, GPRC6A, HCRTR2, P2RY10, HRH1, EDNRA, GNG2, FPR2, TBXA2R, CCK, CCKBR, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, FST, MLNR, NPFF, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, GCGR, TRHR, LTB4R, GNA11, GPR4, BDKRB1, P2RY2, PTAFR, LTB4R2, PMCH, QRFPR, PROKR1, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, TACR3, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, HTR2A, ADRA1A, MCHR1, LPAR2, UTS2
SPRY4FGFR1No-1HRAS
FSHBTAC3No-1GNB1
FSHBPROKR2No-1GNB1
FSHBKISS1RNo-2GNB1, BMP7
FSHBKISS1No-1GNB1
FSHBLHBNo-1CGA
FSHBTACR3No-1GNB1
FSHBFGFR1No-1BMP2
FSHBPROK2No-1GNB1
FSHBGNRH1No-1GNB1
TAC3PROKR2Yesreaction, binding121P2RY6, GPR17, KISS1, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, QRFPR, NTS, EDN3, CYSLTR1, EDN1, NPS, GCGR, SAA1, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GCG, GRM1, EDNRB, CCKBR, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, PROK2, TAC1, GNRHR, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, TRH, GPR132, TACR1, ADRA1B, ANXA1, HCRTR2, P2RY10, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, MLNR, QRFP, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, BDKRB2, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, CHRM5, P2RY2, AVP, LTB4R2, PMCH, PROKR1, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, TACR3, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, UTS2D, LPAR4, NMS, ADRA1D, HTR2A, ADRA1A, MCHR1, LPAR2, UTS2
TAC3KISS1RYesreaction, binding121P2RY6, GPR17, KISS1, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, ANXA1, NTS, EDN3, CYSLTR1, EDN1, NPS, GCGR, SAA1, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GCG, GRM1, EDNRB, QRFP, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, PROK2, TAC1, GNRHR, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, TRH, GPR132, TACR1, ADRA1B, QRFPR, HCRTR2, P2RY10, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, MLNR, CCKBR, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, BDKRB2, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, CHRM5, P2RY2, AVP, LTB4R2, PMCH, PROKR1, GRM5, NPSR1, KNG1, CCKAR, NTSR1, TACR3, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, HTR2A, ADRA1A, MCHR1, LPAR2, UTS2
TAC3KISS1Yesreaction, binding121P2RY6, GPR17, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, QRFPR, NTS, EDN3, CYSLTR1, EDN1, NPS, GCGR, SAA1, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GCG, GRM1, EDNRB, QRFP, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, PROK2, TAC1, GNRHR, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, TRH, GPR132, TACR1, ADRA1B, ANXA1, HCRTR2, P2RY10, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, MLNR, CCKBR, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, BDKRB2, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, CHRM5, P2RY2, AVP, LTB4R2, PMCH, PROKR1, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, TACR3, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, HTR2A, ADRA1A, MCHR1, LPAR2, UTS2
TAC3FGF8No-1EDN1
TAC3TACR3Yesbinding121P2RY6, GPR17, KISS1, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, QRFPR, NTS, EDN3, CYSLTR1, EDN1, NPS, GCGR, SAA1, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GCG, GRM1, EDNRB, QRFP, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, PROK2, TAC1, GNRHR, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, TRH, GPR132, TACR1, ADRA1B, ANXA1, HCRTR2, P2RY10, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, MLNR, CCKBR, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, BDKRB2, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, CHRM5, P2RY2, AVP, LTB4R2, PMCH, PROKR1, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, HTR2A, ADRA1A, MCHR1, LPAR2, UTS2
TAC3FGFR1No-1EDNRA
TAC3PROK2Yesreaction, binding121P2RY6, GPR17, KISS1, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, ANXA1, NTS, EDN3, CYSLTR1, EDN1, NPS, GCGR, SAA1, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GCG, GRM1, EDNRB, QRFP, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, TAC1, GNRHR, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, TRH, GPR132, TACR1, ADRA1B, QRFPR, HCRTR2, P2RY10, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, MLNR, CCKBR, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, BDKRB2, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, CHRM5, P2RY2, AVP, LTB4R2, PMCH, PROKR1, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, TACR3, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, HTR2A, ADRA1A, MCHR1, LPAR2, UTS2
TAC3GNRH1Yesreaction, binding121P2RY6, GPR17, KISS1, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, QRFPR, NTS, EDN3, CYSLTR1, EDN1, NPS, GCGR, SAA1, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GCG, GRM1, EDNRB, QRFP, OXT, GRP, PTAFR, CASR, F2RL1, PROK2, TAC1, GNRHR, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, TRH, GPR132, TACR1, ADRA1B, ANXA1, HCRTR2, P2RY10, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, MLNR, CCKBR, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, BDKRB2, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNA11, GPR4, BDKRB1, CHRM5, P2RY2, AVP, LTB4R2, PMCH, PROKR1, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, TACR3, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, HTR2A, ADRA1A, MCHR1, LPAR2, UTS2
PROKR2KISS1RYesreaction, binding121P2RY6, GPR17, KISS1, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, QRFPR, BDKRB2, EDN3, CYSLTR1, EDN1, NPS, GCGR, SAA1, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GCG, GRM1, EDNRB, CCKBR, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, PROK2, TAC1, TAC3, GNRHR, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, NTS, TRH, GPR132, TACR1, ADRA1B, ANXA1, HCRTR2, P2RY10, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, MLNR, QRFP, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, CHRM5, P2RY2, AVP, LTB4R2, PMCH, PROKR1, GRM5, NPSR1, KNG1, CCKAR, NTSR1, TACR3, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, UTS2D, LPAR4, NMS, ADRA1D, HTR2A, ADRA1A, MCHR1, LPAR2, UTS2
PROKR2KISS1Yesreaction121P2RY6, GPR17, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, QRFPR, NTS, EDN3, CYSLTR1, EDN1, NPS, GCGR, SAA1, AVP, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GCG, GRM1, EDNRB, CCKBR, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, PROK2, TAC1, TAC3, GNRHR, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, TRH, GPR132, TACR1, ADRA1B, ANXA1, HCRTR2, P2RY10, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, MLNR, QRFP, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, CHRM5, P2RY2, BDKRB2, LTB4R2, PMCH, PROKR1, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, TACR3, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, UTS2D, LPAR4, NMS, ADRA1D, HTR2A, ADRA1A, MCHR1, LPAR2, UTS2
PROKR2FGF8No-1EDN1
PROKR2TACR3Yesreaction121P2RY6, GPR17, KISS1, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, QRFPR, NTS, EDN3, CYSLTR1, EDN1, NPS, GCGR, SAA1, AVP, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GCG, GRM1, EDNRB, CCKBR, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, PROK2, TAC1, TAC3, GNRHR, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, TRH, GPR132, TACR1, ADRA1B, ANXA1, HCRTR2, P2RY10, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, MLNR, QRFP, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, CHRM5, P2RY2, BDKRB2, LTB4R2, PMCH, PROKR1, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, UTS2D, LPAR4, NMS, ADRA1D, HTR2A, ADRA1A, MCHR1, LPAR2, UTS2
PROKR2FGFR1No-1EDNRA
PROKR2PROK2Yesbinding121P2RY6, GPR17, KISS1, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, QRFPR, NTS, EDN3, CYSLTR1, EDN1, NPS, GCGR, SAA1, AVP, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GCG, GRM1, EDNRB, CCKBR, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, TAC1, TAC3, GNRHR, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, TRH, GPR132, TACR1, ADRA1B, ANXA1, HCRTR2, P2RY10, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, MLNR, QRFP, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, CHRM5, P2RY2, BDKRB2, LTB4R2, PMCH, PROKR1, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, TACR3, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, UTS2D, LPAR4, NMS, ADRA1D, HTR2A, ADRA1A, MCHR1, LPAR2, UTS2
PROKR2GNRH1Yesreaction, binding121P2RY6, GPR17, KISS1, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, QRFPR, NTS, EDN3, CYSLTR1, EDN1, NPS, GCGR, SAA1, AVP, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GCG, GRM1, EDNRB, CCKBR, OXT, GRP, PTAFR, CASR, F2RL1, PROK2, TAC1, TAC3, GNRHR, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, TRH, GPR132, TACR1, ADRA1B, ANXA1, HCRTR2, P2RY10, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, MLNR, QRFP, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNA11, GPR4, BDKRB1, CHRM5, P2RY2, BDKRB2, LTB4R2, PMCH, PROKR1, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, TACR3, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, UTS2D, LPAR4, NMS, ADRA1D, HTR2A, ADRA1A, MCHR1, LPAR2, UTS2
DUSP6LHBNo-1FOXO1
DUSP6FGF8Yesbinding, activation, expression0
DUSP6FGFR1No-2FGF8, FGF10
DUSP6SEMA3ANo-1WT1
DUSP6GNRH1No-2DUSP4, NOS3
FGF17KISS1RNo-1EGFR
FGF17FGF8No-20FGFR3, GPC1, KIT, INSR, PDGFRB, MET, FGFR1, IGF1R, PDGFRA, CSF1R, EPHA2, FLT4, EGFR, KDR, SHH, FLT1, TEK, NGFR, FGFR4, FGFR2
FGF17FGFR1Yesactivation, binding1GPC1
FGF17HS6ST1No-1GPC1
FGF17GNRH1No-1EGFR
FGF17IL17RDNo-1FGFR1
KISS1RKISS1Yesbinding121P2RY6, GPR17, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, GPRC6A, BDKRB2, EDN3, CYSLTR1, EDN1, NPS, CHRM5, SAA1, NMUR1, XCR1, F2R, GNA14, HCRT, LPAR6, FFAR1, GNRH2, GNRHR, EDN2, F2RL3, GPR68, NMUR2, GRM1, EDNRB, QRFP, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, PROK2, TAC1, TAC3, GCG, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, NTS, TRH, GPR132, TACR1, ADRA1B, ANXA1, HCRTR2, P2RY10, HRH1, EDNRA, GNG2, FPR2, TBXA2R, CCK, CCKBR, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, MLNR, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, GCGR, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, P2RY2, AVP, LTB4R2, PMCH, QRFPR, HTR2A, GRM5, NPSR1, KNG1, CCKAR, NTSR1, TACR3, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, PROKR1, ADRA1A, MCHR1, LPAR2, UTS2
KISS1RFGF8No-2EGFR, EDN1
KISS1RTACR3Yesreaction, binding121P2RY6, GPR17, KISS1, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, ANXA1, NTS, EDN3, CYSLTR1, EDN1, NPS, GCGR, SAA1, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GCG, GRM1, EDNRB, QRFP, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, PROK2, TAC1, TAC3, GNRHR, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, TRH, GPR132, TACR1, ADRA1B, QRFPR, HCRTR2, P2RY10, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, MLNR, CCKBR, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, BDKRB2, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, CHRM5, P2RY2, AVP, LTB4R2, PMCH, PROKR1, GRM5, NPSR1, KNG1, CCKAR, NTSR1, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, HTR2A, ADRA1A, MCHR1, LPAR2, UTS2
KISS1RFGFR1No-1EDNRA
KISS1RPROK2Yesreaction, binding121P2RY6, GPR17, KISS1, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, QRFPR, BDKRB2, EDN3, CYSLTR1, EDN1, NPS, GCGR, SAA1, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GCG, GRM1, EDNRB, QRFP, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, TAC1, TAC3, GNRHR, OPN4, FFAR3, P2RY10, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, NTS, TRH, GPR132, TACR1, ADRA1B, ANXA1, HCRTR2, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, CCK, CCKBR, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, MLNR, NPFF, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, CHRM5, P2RY2, AVP, LTB4R2, PMCH, HTR2A, GRM5, NPSR1, KNG1, CCKAR, NTSR1, TACR3, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, PROKR1, ADRA1A, MCHR1, LPAR2, UTS2
KISS1RGNRH1Yesreaction, binding122P2RY6, GPR17, KISS1, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, GPRC6A, BDKRB2, EDN3, CYSLTR1, EDN1, NPS, CHRM5, SAA1, NMUR1, XCR1, F2R, GNA14, HCRT, LPAR6, FFAR1, GNRH2, GNRHR, EDN2, F2RL3, GPR68, NMUR2, GRM1, EDNRB, QRFP, OXT, GRP, PTAFR, CASR, F2RL1, PROK2, TAC1, TAC3, GCG, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, EGFR, FFAR2, PROK1, XCL2, NTS, TRH, GPR132, TACR1, ADRA1B, ANXA1, HCRTR2, P2RY10, HRH1, EDNRA, GNG2, FPR2, TBXA2R, CCK, CCKBR, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, MLNR, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, GCGR, TRHR, LTB4R, GNA11, GPR4, BDKRB1, P2RY2, AVP, LTB4R2, PMCH, QRFPR, HTR2A, GRM5, NPSR1, KNG1, CCKAR, NTSR1, TACR3, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, PROKR1, ADRA1A, MCHR1, LPAR2, UTS2
KISS1FGF8No-1EDN1
KISS1TACR3Yesreaction121P2RY6, GPR17, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, QRFPR, NTS, EDN3, CYSLTR1, EDN1, NPS, GCGR, SAA1, AVP, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GCG, GRM1, EDNRB, QRFP, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, PROK2, TAC1, TAC3, GNRHR, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, TRH, GPR132, TACR1, ADRA1B, ANXA1, HCRTR2, P2RY10, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, MLNR, CCKBR, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, CHRM5, P2RY2, BDKRB2, LTB4R2, PMCH, PROKR1, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, HTR2A, ADRA1A, MCHR1, LPAR2, UTS2
KISS1FGFR1No-2SP1, EDNRA
KISS1PROK2Yesreaction122P2RY6, GPR17, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, QRFPR, UTS2, EDN3, CYSLTR1, EDN1, NPS, GCGR, SAA1, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GCG, GRM1, EDNRB, QRFP, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, LPAR3, TAC1, TAC3, GNRHR, OPN4, FFAR3, P2RY10, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, NTS, TRH, GPR132, TACR1, ADRA1B, ANXA1, HCRTR2, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, MLNR, CCKBR, FOS, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, BDKRB2, NPFF, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, CHRM5, P2RY2, AVP, LTB4R2, PMCH, HTR2A, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, TACR3, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, PROKR1, ADRA1A, MCHR1, LPAR2
KISS1GNRH1Yesactivation, binding122P2RY6, GPR17, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, GPRC6A, BDKRB2, EDN3, CYSLTR1, EDN1, NPS, CHRM5, SAA1, NMUR1, XCR1, F2R, GNA14, HCRT, LPAR6, FFAR1, GNRH2, GNRHR, EDN2, F2RL3, GPR68, NMUR2, GRM1, EDNRB, QRFP, OXT, GRP, PTAFR, CASR, F2RL1, LPAR3, PROK2, TAC1, TAC3, GCG, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, NTS, TRH, GPR132, TACR1, ADRA1B, ANXA1, HCRTR2, P2RY10, HRH1, EDNRA, GNG2, FPR2, TBXA2R, MLNR, CCKBR, FOS, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, GCGR, TRHR, LTB4R, GNA11, GPR4, BDKRB1, P2RY2, AVP, LTB4R2, PMCH, QRFPR, PROKR1, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, TACR3, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, HTR2A, ADRA1A, MCHR1, LPAR2, UTS2
LHBFGFR1No-1INS
LHBGNRH1No-1EGR1
FGF8TACR3No-1EDN1
FGF8FGFR1Yesactivation, binding4BMP4, GPC1, FGF19, SOX2
FGF8PROK2No-1EDN1
FGF8HS6ST1No-1GPC1
FGF8GNRH1No-2EGFR, EDN1
FGF8IL17RDNo-1FGFR1
TACR3FGFR1No-1EDNRA
TACR3PROK2Yesreaction121P2RY6, GPR17, KISS1, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, ANXA1, NTS, EDN3, CYSLTR1, EDN1, NPS, GCGR, SAA1, AVP, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GCG, GRM1, EDNRB, QRFP, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, TAC1, TAC3, GNRHR, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, TRH, GPR132, TACR1, ADRA1B, QRFPR, HCRTR2, P2RY10, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, MLNR, CCKBR, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, CHRM5, P2RY2, BDKRB2, LTB4R2, PMCH, PROKR1, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, HTR2A, ADRA1A, MCHR1, LPAR2, UTS2
TACR3GNRH1Yesreaction, binding121P2RY6, GPR17, KISS1, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, QRFPR, NTS, EDN3, CYSLTR1, EDN1, NPS, GCGR, SAA1, AVP, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GCG, GRM1, EDNRB, QRFP, OXT, GRP, PTAFR, CASR, F2RL1, PROK2, TAC1, TAC3, GNRHR, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, TRH, GPR132, TACR1, ADRA1B, ANXA1, HCRTR2, P2RY10, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, MLNR, CCKBR, LPAR3, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNA11, GPR4, BDKRB1, CHRM5, P2RY2, BDKRB2, LTB4R2, PMCH, PROKR1, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, HTR2A, ADRA1A, MCHR1, LPAR2, UTS2
FGFR1PROK2No-1EDNRA
FGFR1HS6ST1No-3SDC1, GPC1, SDC4
FGFR1GNRH1No-1EDNRA
FGFR1IL17RDYesbinding0
PROK2GNRH1Yesreaction, binding122P2RY6, GPR17, KISS1, AGT, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, QRFPR, UTS2, EDN3, CYSLTR1, EDN1, NPS, GCGR, SAA1, NMUR1, XCR1, F2R, HCRT, LPAR6, FFAR1, GNRH2, GNA14, EDN2, F2RL3, GPR68, NMUR2, GCG, GRM1, EDNRB, QRFP, OXT, GRP, PTAFR, CASR, F2RL1, LPAR3, TAC1, TAC3, GNRHR, OPN4, FFAR3, P2RY10, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, XCL2, NTS, TRH, GPR132, TACR1, ADRA1B, ANXA1, HCRTR2, HRH1, GPRC6A, EDNRA, GNG2, FPR2, TBXA2R, MLNR, CCKBR, FOS, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, BDKRB2, NPFF, MCHR2, NMB, AGTR1, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GNAQ, MLN, TRHR, LTB4R, GNA11, GPR4, BDKRB1, CHRM5, P2RY2, AVP, LTB4R2, PMCH, HTR2A, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, TACR3, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, GRPR, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, PROKR1, ADRA1A, MCHR1, LPAR2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Neuroactive ligand-receptor interactionhsa040804.585LHB, FSHB, TACR3, GNRHR, KISS1R
GnRH signaling pathwayhsa049126.184LHB, GNRH1, GNRHR, FSHB
MAPK signaling pathwayhsa040104.634DUSP6, FGF8, FGFR1, FGF17
Melanomahsa052186.563FGF8, FGFR1, FGF17
Pathways in cancerhsa052003.983FGF8, FGFR1, FGF17
Rap1 signaling pathwayhsa040154.973FGF8, FGFR1, FGF17
Ras signaling pathwayhsa040144.93FGF8, FGFR1, FGF17
PI3K-Akt signaling pathwayhsa041514.213FGF8, FGFR1, FGF17
Regulation of actin cytoskeletonhsa048104.93FGF8, FGFR1, FGF17
Ovarian steroidogenesishsa049137.072LHB, FSHB

NET-GE enrichment

Term New enriched termICP valueGenes
Melanoma (hsa05218) -6.560.011FGFR1, FGF8, DUSP6, FGF17
Environmental Information ProcessingNEW1.710.029FSHB, FGFR1, SPRY4, FGF8, KISS1R, TACR3, FGF17, LHB, DUSP6, GNRHR
GnRH signaling pathway (hsa04912) -6.180.018LHB, GNRH1, GNRHR, FSHB
Signal transductionNEW2.060.048FGF8, FSHB, SPRY4, GNRH1, TACR3, KISS1R, FGFR1, KISS1, SEMA3A, LHB, DUSP6, PROK2, FGF17
Rap1 signaling pathway (hsa04015) -4.970.012GNRH1, SPRY4, FGF8, FGFR1, DUSP6, FGF17
Ras signaling pathway (hsa04014) -4.90.01SPRY4, GNRH1, FGF8, FGFR1, DUSP6, FGF17
MAPK signaling pathway (hsa04010) -4.630.024GNRH1, SPRY4, FGF8, FGFR1, DUSP6, FGF17
Neuroactive ligand-receptor interaction (hsa04080) -4.580.004FSHB, GNRH1, KISS1R, TACR3, LHB, GNRHR
PI3K-Akt signaling pathway (hsa04151) -4.210.025PROK2, GNRH1, KISS1R, FGF8, FGFR1, DUSP6, FGF17
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signal TransductionR-HSA-1625821.7816ANOS1, TACR3, IL17RD, FGFR1, FSHB, PROK2, GNRH1, FGF8, KISS1R, TAC3, KISS1, GNRHR, LHB, PROKR2, DUSP6, FGF17
Signaling by GPCRR-HSA-3727902.6815TACR3, IL17RD, FGFR1, FSHB, PROK2, GNRH1, FGF8, KISS1R, TAC3, KISS1, GNRHR, LHB, PROKR2, DUSP6, FGF17
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.2613TACR3, GNRHR, IL17RD, DUSP6, GNRH1, KISS1, KISS1R, FGFR1, FGF8, FGF17, PROKR2, PROK2, TAC3
GPCR downstream signalingR-HSA-3883963.0710FSHB, GNRH1, TACR3, KISS1R, KISS1, GNRHR, LHB, PROKR2, PROK2, TAC3
Class A/1 (Rhodopsin-like receptors)R-HSA-3730764.6910FSHB, GNRH1, TACR3, KISS1R, KISS1, GNRHR, LHB, PROKR2, PROK2, TAC3
GPCR ligand bindingR-HSA-5007924.1910FSHB, GNRH1, TACR3, KISS1R, KISS1, GNRHR, LHB, PROKR2, PROK2, TAC3
G alpha (q) signalling eventsR-HSA-4164765.428GNRH1, TACR3, KISS1R, KISS1, TAC3, PROKR2, PROK2, GNRHR
Signaling by FGFR1R-HSA-56547364.696ANOS1, IL17RD, DUSP6, FGF8, FGFR1, FGF17
Axon guidanceR-HSA-4224753.936IL17RD, DUSP6, SEMA3A, FGF8, FGFR1, FGF17
Developmental BiologyR-HSA-12667383.486IL17RD, DUSP6, SEMA3A, FGF8, FGFR1, FGF17
Peptide ligand-binding receptorsR-HSA-3752765.416KISS1, KISS1R, TACR3, PROKR2, PROK2, TAC3
Signaling by FGFRR-HSA-1902364.676ANOS1, IL17RD, DUSP6, FGF8, FGFR1, FGF17
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.855FGFR1, IL17RD, DUSP6, FGF8, FGF17
Immune SystemR-HSA-1682562.375FGFR1, IL17RD, DUSP6, FGF8, FGF17
NCAM signaling for neurite out-growthR-HSA-3751654.95FGFR1, IL17RD, DUSP6, FGF8, FGF17
Signalling to p38 via RIT and RINR-HSA-1877065.125FGFR1, IL17RD, DUSP6, FGF8, FGF17
Signaling by InterleukinsR-HSA-4491474.715FGFR1, IL17RD, DUSP6, FGF8, FGF17
GRB2 events in ERBB2 signalingR-HSA-19636405.155FGFR1, IL17RD, DUSP6, FGF8, FGF17
Frs2-mediated activationR-HSA-1709685.125FGFR1, IL17RD, DUSP6, FGF8, FGF17
Cytokine Signaling in Immune systemR-HSA-12802153.745FGFR1, IL17RD, DUSP6, FGF8, FGF17
IGF1R signaling cascadeR-HSA-24289244.855FGFR1, IL17RD, DUSP6, FGF8, FGF17
Downstream signal transductionR-HSA-1867634.655FGFR1, IL17RD, DUSP6, FGF8, FGF17
IRS-related events triggered by IGF1RR-HSA-24289284.855FGFR1, IL17RD, DUSP6, FGF8, FGF17
Signaling by ERBB4R-HSA-12363944.75FGFR1, IL17RD, DUSP6, FGF8, FGF17
DAP12 interactionsR-HSA-21721274.565FGFR1, IL17RD, DUSP6, FGF8, FGF17
Signaling by Insulin receptorR-HSA-747524.735FGFR1, IL17RD, DUSP6, FGF8, FGF17
RAF/MAP kinase cascadeR-HSA-56730015.155FGFR1, IL17RD, DUSP6, FGF8, FGF17
Downstream signaling of activated FGFR1R-HSA-56546874.715FGFR1, IL17RD, DUSP6, FGF8, FGF17
MAPK family signaling cascadesR-HSA-56830574.895FGFR1, IL17RD, DUSP6, FGF8, FGF17
Signaling by LeptinR-HSA-25865525.15FGFR1, IL17RD, DUSP6, FGF8, FGF17
Signaling by VEGFR-HSA-1941384.665FGFR1, IL17RD, DUSP6, FGF8, FGF17
MAPK1/MAPK3 signalingR-HSA-56849965.115FGFR1, IL17RD, DUSP6, FGF8, FGF17
FCERI mediated MAPK activationR-HSA-28717964.325FGFR1, IL17RD, DUSP6, FGF8, FGF17
IRS-mediated signallingR-HSA-1123994.875FGFR1, IL17RD, DUSP6, FGF8, FGF17
FRS-mediated FGFR2 signalingR-HSA-56547005.145FGFR1, IL17RD, DUSP6, FGF8, FGF17
SOS-mediated signallingR-HSA-1124125.155FGFR1, IL17RD, DUSP6, FGF8, FGF17
FRS-mediated FGFR3 signalingR-HSA-56547065.145FGFR1, IL17RD, DUSP6, FGF8, FGF17
Downstream signaling of activated FGFR3R-HSA-56547084.715FGFR1, IL17RD, DUSP6, FGF8, FGF17
Insulin receptor signalling cascadeR-HSA-747514.855FGFR1, IL17RD, DUSP6, FGF8, FGF17
Signaling by FGFR4R-HSA-56547434.695FGFR1, IL17RD, DUSP6, FGF8, FGF17
Signaling by FGFR3R-HSA-56547414.695FGFR1, IL17RD, DUSP6, FGF8, FGF17
VEGFA-VEGFR2 PathwayR-HSA-44200974.75FGFR1, IL17RD, DUSP6, FGF8, FGF17
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.035FGFR1, IL17RD, DUSP6, FGF8, FGF17
Interleukin-2 signalingR-HSA-4519275.055FGFR1, IL17RD, DUSP6, FGF8, FGF17
Interleukin receptor SHC signalingR-HSA-9125265.095FGFR1, IL17RD, DUSP6, FGF8, FGF17
Innate Immune SystemR-HSA-1682493.175FGFR1, IL17RD, DUSP6, FGF8, FGF17
Signaling by SCF-KITR-HSA-14335574.735FGFR1, IL17RD, DUSP6, FGF8, FGF17
Signaling by PDGFR-HSA-1867974.535FGFR1, IL17RD, DUSP6, FGF8, FGF17
Signalling to RASR-HSA-1670445.085FGFR1, IL17RD, DUSP6, FGF8, FGF17
DAP12 signalingR-HSA-24244914.645FGFR1, IL17RD, DUSP6, FGF8, FGF17
SHC1 events in EGFR signalingR-HSA-1803365.155FGFR1, IL17RD, DUSP6, FGF8, FGF17
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.995FGFR1, IL17RD, DUSP6, FGF8, FGF17
Downstream signaling of activated FGFR2R-HSA-56546964.715FGFR1, IL17RD, DUSP6, FGF8, FGF17
SHC1 events in ERBB4 signalingR-HSA-12503475.155FGFR1, IL17RD, DUSP6, FGF8, FGF17
Signaling by EGFRR-HSA-1779294.595FGFR1, IL17RD, DUSP6, FGF8, FGF17
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.515FGFR1, IL17RD, DUSP6, FGF8, FGF17
FRS-mediated FGFR1 signalingR-HSA-56546935.145FGFR1, IL17RD, DUSP6, FGF8, FGF17
Prolonged ERK activation eventsR-HSA-1698935.115FGFR1, IL17RD, DUSP6, FGF8, FGF17
Signalling to ERKsR-HSA-1876875.045FGFR1, IL17RD, DUSP6, FGF8, FGF17
Signalling by NGFR-HSA-1665204.235FGFR1, IL17RD, DUSP6, FGF8, FGF17
Signaling by FGFR2R-HSA-56547384.685FGFR1, IL17RD, DUSP6, FGF8, FGF17
GRB2 events in EGFR signalingR-HSA-1798125.155FGFR1, IL17RD, DUSP6, FGF8, FGF17
SHC1 events in ERBB2 signalingR-HSA-12501965.155FGFR1, IL17RD, DUSP6, FGF8, FGF17
ARMS-mediated activationR-HSA-1709845.125FGFR1, IL17RD, DUSP6, FGF8, FGF17
FRS-mediated FGFR4 signalingR-HSA-56547125.145FGFR1, IL17RD, DUSP6, FGF8, FGF17
Downstream signaling of activated FGFR4R-HSA-56547164.715FGFR1, IL17RD, DUSP6, FGF8, FGF17
Signaling by ERBB2R-HSA-12279864.665FGFR1, IL17RD, DUSP6, FGF8, FGF17
VEGFR2 mediated cell proliferationR-HSA-52189215.075FGFR1, IL17RD, DUSP6, FGF8, FGF17
FGFR1 ligand binding and activationR-HSA-1902428.984ANOS1, FGF8, FGFR1, FGF17
Hormone ligand-binding receptorsR-HSA-3752819.524LHB, GNRH1, FSHB, GNRHR
FGFR1c ligand binding and activationR-HSA-1903739.44ANOS1, FGF8, FGFR1, FGF17
PI3K/AKT activationR-HSA-1982036.323FGF8, FGFR1, FGF17
Constitutive Signaling by Aberrant PI3K in CancerR-HSA-22195307.053FGF8, FGFR1, FGF17
PI3K events in ERBB2 signalingR-HSA-19636426.373FGF8, FGFR1, FGF17
GAB1 signalosomeR-HSA-1802926.313FGF8, FGFR1, FGF17
Adaptive Immune SystemR-HSA-12802183.193FGF8, FGFR1, FGF17
DiseaseR-HSA-16436853.333FGF8, FGFR1, FGF17
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.953FGF8, FGFR1, FGF17
PIP3 activates AKT signalingR-HSA-12576046.373FGF8, FGFR1, FGF17
PI-3K cascade:FGFR3R-HSA-56547106.373FGF8, FGFR1, FGF17
PI-3K cascade:FGFR4R-HSA-56547206.373FGF8, FGFR1, FGF17
PI-3K cascade:FGFR1R-HSA-56546896.373FGF8, FGFR1, FGF17
SHC-mediated cascade:FGFR1R-HSA-56546888.593FGF8, FGFR1, FGF17
Negative regulation of FGFR1 signalingR-HSA-56547267.983FGF8, FGFR1, FGF17
Phospholipase C-mediated cascade: FGFR1R-HSA-56542197.433FGF8, FGFR1, FGF17
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.593FGF8, FGFR1, FGF17
Signaling by activated point mutants of FGFR1R-HSA-18391229.523FGF8, FGFR1, FGF17
FGFR1 mutant receptor activationR-HSA-18391248.123FGF8, FGFR1, FGF17
Signaling by FGFR in diseaseR-HSA-12260997.493FGF8, FGFR1, FGF17
PI3K/AKT Signaling in CancerR-HSA-22195286.563FGF8, FGFR1, FGF17
Diseases of signal transductionR-HSA-56632024.893FGF8, FGFR1, FGF17
Signaling by FGFR1 in diseaseR-HSA-56553027.813FGF8, FGFR1, FGF17
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.623FGF8, FGFR1, FGF17
PI-3K cascade:FGFR2R-HSA-56546956.373FGF8, FGFR1, FGF17
PI3K events in ERBB4 signalingR-HSA-12503426.373FGF8, FGFR1, FGF17
PI3K CascadeR-HSA-1097046.683FGF8, FGFR1, FGF17
Phospholipase C-mediated cascade; FGFR2R-HSA-56542217.372FGF8, FGF17
Signaling by FGFR3 in diseaseR-HSA-56553328.522FGF8, FGF17
Phospholipase C-mediated cascade; FGFR4R-HSA-56542287.462FGF8, FGF17
FGFR2 ligand binding and activationR-HSA-1902418.662FGF8, FGF17
MetabolismR-HSA-14307282.342LHB, HS6ST1
G alpha (s) signalling eventsR-HSA-4185555.992LHB, FSHB
FGFR2c ligand binding and activationR-HSA-1903759.282FGF8, FGF17
FGFR3c ligand binding and activationR-HSA-1903729.42FGF8, FGF17
Phospholipase C-mediated cascade; FGFR3R-HSA-56542277.522FGF8, FGF17
FGFR3b ligand binding and activationR-HSA-19037110.182FGF8, FGF17
Tachykinin receptors bind tachykininsR-HSA-38009510.662TACR3, TAC3
Peptide hormone metabolismR-HSA-29807366.612LHB, FSHB
Negative regulation of FGFR2 signalingR-HSA-56547277.892FGF8, FGF17
SHC-mediated cascade:FGFR3R-HSA-56547048.812FGF8, FGF17
Peptide hormone biosynthesisR-HSA-2099529.42LHB, FSHB
FGFR2 mutant receptor activationR-HSA-18391268.892FGF8, FGF17
Activated point mutants of FGFR2R-HSA-20335198.892FGF8, FGF17
FGFR3 mutant receptor activationR-HSA-20335149.42FGF8, FGF17
FGFR3 ligand binding and activationR-HSA-1902399.42FGF8, FGF17
Metabolism of proteinsR-HSA-3924993.412LHB, FSHB
SHC-mediated cascade:FGFR2R-HSA-56546998.282FGF8, FGF17
Glycoprotein hormonesR-HSA-2098229.662LHB, FSHB
Negative regulation of FGFR4 signalingR-HSA-56547338.032FGF8, FGF17
Negative regulation of FGFR3 signalingR-HSA-56547328.122FGF8, FGF17
FGFR4 ligand binding and activationR-HSA-1903229.182FGF8, FGF17
SHC-mediated cascade:FGFR4R-HSA-56547198.462FGF8, FGF17
Signaling by activated point mutants of FGFR3R-HSA-18391309.42FGF8, FGF17
Signaling by FGFR2 in diseaseR-HSA-56552538.232FGF8, FGF17

NET-GE enrichment

Term New enriched termICP valueGenes
Phospholipase C-mediated cascade; FGFR2 (R-HSA-5654221) -7.370.006DUSP6, FGF8, FGFR1, FGF17
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (R-HSA-2404192) -4.850.048DUSP6, FGF8, FGFR1, IL17RD, FGF17
Gastrin-CREB signalling pathway via PKC and MAPK (R-HSA-881907) -4.260.0IL17RD, FGF17, DUSP6, GNRH1, TACR3, KISS1R, FGFR1, FGF8, SPRY4, GNRHR, KISS1, PROKR2, PROK2, TAC3
Phospholipase C-mediated cascade; FGFR3 (R-HSA-5654227) -7.520.003FGFR1, FGF8, DUSP6, FGF17
Signaling by Interleukins (R-HSA-449147) -4.710.04IL17RD, GNRH1, SPRY4, FGF8, FGFR1, DUSP6, FGF17
FGFR1 ligand binding and activation (R-HSA-190242) -8.980.0ANOS1, FGF8, FGFR1, FGF17
Phospholipase C-mediated cascade; FGFR4 (R-HSA-5654228) -7.460.004FGFR1, FGF8, DUSP6, FGF17
GRB2 events in ERBB2 signaling (R-HSA-1963640) -5.150.048IL17RD, FGFR1, SPRY4, FGF8, DUSP6, FGF17
Frs2-mediated activation (R-HSA-170968) -5.120.02DUSP6, FGF8, FGFR1, IL17RD, FGF17
Peptide ligand-binding receptors (R-HSA-375276) -5.410.002KISS1, KISS1R, TACR3, PROKR2, PROK2, TAC3
Insulin receptor signalling cascade (R-HSA-74751) -4.850.047FGFR1, IL17RD, DUSP6, FGF8, FGF17
IGF1R signaling cascade (R-HSA-2428924) -4.850.048FGFR1, FGF8, DUSP6, IL17RD, FGF17
IRS-related events triggered by IGF1R (R-HSA-2428928) -4.850.048DUSP6, IL17RD, FGFR1, FGF8, FGF17
IRS-mediated signalling (R-HSA-112399) -4.870.045FGFR1, IL17RD, DUSP6, FGF8, FGF17
MAPK1/MAPK3 signaling (R-HSA-5684996) -5.110.02FGFR1, IL17RD, DUSP6, FGF8, FGF17
RAF/MAP kinase cascade (R-HSA-5673001) -5.150.048IL17RD, FGFR1, SPRY4, FGF8, DUSP6, FGF17
FGFR1c ligand binding and activation (R-HSA-190373) -9.40.0ANOS1, FGF8, FGFR1, FGF17
Signaling by Leptin (R-HSA-2586552) -5.10.021FGFR1, FGF8, DUSP6, IL17RD, FGF17
FGFR3b ligand binding and activation (R-HSA-190371) -10.180.016FGF8, FGF17
Tachykinin receptors bind tachykinins (R-HSA-380095) -10.660.008TACR3, TAC3
SHC1 events in ERBB2 signaling (R-HSA-1250196) -5.150.048IL17RD, FGFR1, SPRY4, FGF8, DUSP6, FGF17
SHC-mediated cascade:FGFR1 (R-HSA-5654688) -8.590.002FGF8, FGFR1, FGF17
Negative regulation of FGFR1 signaling (R-HSA-5654726) -7.980.007FGFR1, FGF8, DUSP6, FGF17
Negative regulation of FGFR2 signaling (R-HSA-5654727) -7.890.0FGFR1, FGF8, DUSP6, FGF17
Phospholipase C-mediated cascade: FGFR1 (R-HSA-5654219) -7.430.006FGFR1, FGF8, DUSP6, FGF17
FRS-mediated FGFR2 signaling (R-HSA-5654700) -5.140.048IL17RD, FGFR1, SPRY4, FGF8, DUSP6, FGF17
FRS-mediated FGFR4 signaling (R-HSA-5654712) -5.140.048IL17RD, FGFR1, SPRY4, FGF8, DUSP6, FGF17
FRS-mediated FGFR3 signaling (R-HSA-5654706) -5.140.048IL17RD, FGFR1, SPRY4, FGF8, DUSP6, FGF17
Signaling by activated point mutants of FGFR1 (R-HSA-1839122) -9.520.0FGF8, FGFR1, FGF17
FGFR1 mutant receptor activation (R-HSA-1839124) -8.120.005FGF8, FGFR1, FGF17
Signaling by FGFR in disease (R-HSA-1226099) -7.490.021FGF8, FGFR1, FGF17
Signaling by FGFR (R-HSA-190236) -4.670.007ANOS1, IL17RD, DUSP6, FGF8, FGFR1, FGF17
GPCR downstream signaling (R-HSA-388396) -3.070.006FSHB, SPRY4, GNRH1, TACR3, KISS1R, KISS1, GNRHR, LHB, PROKR2, PROK2, TAC3
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076) -4.690.0FSHB, GNRH1, TACR3, KISS1R, KISS1, GNRHR, LHB, PROKR2, PROK2, TAC3
Interleukin receptor SHC signaling (R-HSA-912526) -5.090.022FGFR1, IL17RD, DUSP6, FGF8, FGF17
Signalling to p38 via RIT and RIN (R-HSA-187706) -5.120.02FGFR1, IL17RD, DUSP6, FGF8, FGF17
Interleukin-2 signaling (R-HSA-451927) -5.050.025FGFR1, IL17RD, DUSP6, FGF8, FGF17
Signaling by FGFR1 in disease (R-HSA-5655302) -7.810.011FGF8, FGFR1, FGF17
NCAM signaling for neurite out-growth (R-HSA-375165) -4.90.041FGFR1, IL17RD, DUSP6, FGF8, FGF17
Signaling by FGFR3 in disease (R-HSA-5655332) -8.520.003FGF8, FGFR1, FGF17
SHC-mediated cascade:FGFR2 (R-HSA-5654699) -8.280.008FGF8, FGFR1, FGF17
Interleukin-3, 5 and GM-CSF signaling (R-HSA-512988) -4.990.03FGFR1, IL17RD, DUSP6, FGF8, FGF17
Signaling by FGFR1 (R-HSA-5654736) -4.690.007ANOS1, IL17RD, DUSP6, FGF8, FGFR1, FGF17
SHC1 events in EGFR signaling (R-HSA-180336) -5.150.048IL17RD, FGFR1, SPRY4, FGF8, DUSP6, FGF17
Glycoprotein hormones (R-HSA-209822) -9.660.035LHB, FSHB
FRS-mediated FGFR1 signaling (R-HSA-5654693) -5.140.048IL17RD, FGFR1, SPRY4, FGF8, DUSP6, FGF17
Prolonged ERK activation events (R-HSA-169893) -5.110.021FGFR1, IL17RD, DUSP6, FGF8, FGF17
GPCR ligand binding (R-HSA-500792) -4.190.0TACR3, FSHB, FGFR1, GNRH1, FGF8, KISS1R, KISS1, GNRHR, LHB, PROKR2, PROK2, TAC3
Hormone ligand-binding receptors (R-HSA-375281) -9.520.0LHB, GNRH1, FSHB, GNRHR
Signaling by GPCR (R-HSA-372790) -2.680.0TACR3, IL17RD, FSHB, GNRH1, SPRY4, FGF8, KISS1R, FGFR1, GNRHR, KISS1, TAC3, LHB, PROKR2, DUSP6, PROK2, FGF17
GRB2 events in EGFR signaling (R-HSA-179812) -5.150.048IL17RD, FGFR1, SPRY4, FGF8, DUSP6, FGF17
Signalling to ERKs (R-HSA-187687) -5.040.026DUSP6, IL17RD, FGFR1, FGF8, FGF17
Negative regulation of FGFR4 signaling (R-HSA-5654733) -8.030.0FGFR1, FGF8, DUSP6, FGF17
Negative regulation of FGFR3 signaling (R-HSA-5654732) -8.120.0FGFR1, FGF8, DUSP6, FGF17
G alpha (q) signalling events (R-HSA-416476) -5.420.0SPRY4, GNRH1, TACR3, KISS1R, KISS1, GNRHR, PROKR2, PROK2, TAC3
ARMS-mediated activation (R-HSA-170984) -5.120.02FGFR1, IL17RD, DUSP6, FGF8, FGF17
SOS-mediated signalling (R-HSA-112412) -5.150.048IL17RD, FGFR1, SPRY4, FGF8, DUSP6, FGF17
Signal Transduction (R-HSA-162582) -1.780.0ANOS1, TACR3, IL17RD, FGFR1, FSHB, DUSP6, GNRH1, FGF8, KISS1R, TAC3, KISS1, GNRHR, LHB, PROKR2, PROK2, FGF17
SHC1 events in ERBB4 signaling (R-HSA-1250347) -5.150.048IL17RD, FGFR1, SPRY4, FGF8, DUSP6, FGF17
SHC-mediated cascade:FGFR4 (R-HSA-5654719) -8.460.005FGF8, FGFR1, FGF17
MAPK family signaling cascades (R-HSA-5683057) -4.890.041FGFR1, FGF8, DUSP6, IL17RD, FGF17
VEGFR2 mediated cell proliferation (R-HSA-5218921) -5.070.023FGFR1, IL17RD, DUSP6, FGF8, FGF17
Signaling by FGFR2 in disease (R-HSA-5655253) -8.230.006FGF8, FGFR1, FGF17
Signalling to RAS (R-HSA-167044) -5.080.022FGFR1, IL17RD, DUSP6, FGF8, FGF17
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.1820ANOS1, TACR3, GNRHR, WDR11, FGF8, SPRY4, FGF17, GNRH1, CHD7, KISS1R, FGFR1, FEZF1, KISS1, NSMF, SEMA3A, FLRT3, LHB, FSHB, PROK2, TAC3
protein binding (GO:0005515) 0.4618ANOS1, TACR3, FGF8, FGFR1, WDR11, FSHB, GNRH1, SPRY4, CHD7, KISS1R, TAC3, KISS1, NSMF, SEMA3A, FLRT3, LHB, PROK2, FGF17
receptor binding (GO:0005102) 2.4310FGF17, FSHB, GNRH1, FGF8, SEMA3A, KISS1, FLRT3, LHB, PROK2, TAC3
signal transducer activity (GO:0004871) 2.287IL17RD, FLRT3, TACR3, KISS1R, PROKR2, FGFR1, GNRHR
signaling receptor activity (GO:0038023) 2.496IL17RD, KISS1R, TACR3, PROKR2, FGFR1, GNRHR
catalytic activity (GO:0003824) 1.056FGFR1, FGF8, CHD7, HS6ST1, DUSP6, FGF17
molecular transducer activity (GO:0060089) 2.326IL17RD, KISS1R, TACR3, PROKR2, FGFR1, GNRHR
transmembrane signaling receptor activity (GO:0004888) 2.576IL17RD, KISS1R, TACR3, PROKR2, FGFR1, GNRHR
receptor activity (GO:0004872) 2.326IL17RD, KISS1R, TACR3, PROKR2, FGFR1, GNRHR
transmembrane receptor activity (GO:0099600) 2.536IL17RD, KISS1R, TACR3, PROKR2, FGFR1, GNRHR
molecular function regulator (GO:0098772) 2.515ANOS1, FGF8, FGFR1, FGF17, FLRT3
transferase activity (GO:0016740) 1.954HS6ST1, FGFR1, FGF8, FGF17
G-protein coupled receptor activity (GO:0004930) 2.954KISS1R, PROKR2, TACR3, GNRHR
hormone activity (GO:0005179) 4.953LHB, GNRH1, FSHB
Ras guanyl-nucleotide exchange factor activity (GO:0005088) 4.313FGF8, FGFR1, FGF17
growth factor receptor binding (GO:0070851) 4.873FGF8, FGF17, FLRT3
G-protein coupled peptide receptor activity (GO:0008528) 4.863PROKR2, TACR3, KISS1R
phosphatidylinositol bisphosphate kinase activity (GO:0052813) 5.563FGF8, FGFR1, FGF17
carbohydrate derivative binding (GO:0097367) 2.033ANOS1, CHD7, FGFR1
1-phosphatidylinositol-3-kinase activity (GO:0016303) 5.983FGF8, FGFR1, FGF17
kinase activity (GO:0016301) 2.933FGF8, FGFR1, FGF17
guanyl-nucleotide exchange factor activity (GO:0005085) 4.023FGF8, FGFR1, FGF17
phosphatidylinositol kinase activity (GO:0052742) 5.813FGF8, FGFR1, FGF17
fibroblast growth factor receptor binding (GO:0005104) 6.413FGF8, FGF17, FLRT3
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.083FGF8, FGFR1, FGF17
peptide receptor activity (GO:0001653) 4.843PROKR2, TACR3, KISS1R
protein tyrosine kinase activity (GO:0004713) 4.543FGF8, FGFR1, FGF17
phosphatidylinositol 3-kinase activity (GO:0035004) 5.493FGF8, FGFR1, FGF17
neuropeptide receptor activity (GO:0008188) 5.953PROKR2, TACR3, KISS1R
protein kinase activity (GO:0004672) 3.273FGF8, FGFR1, FGF17
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.773FGF8, FGFR1, FGF17
organic cyclic compound binding (GO:0097159) 1.053FEZF1, CHD7, FGFR1
heterocyclic compound binding (GO:1901363) 1.063FEZF1, CHD7, FGFR1
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934) 5.613FGF8, FGFR1, FGF17
purine ribonucleoside triphosphate binding (GO:0035639) 2.222CHD7, FGFR1
RNA polymerase II regulatory region DNA binding (GO:0001012) 3.362FEZF1, CHD7
core promoter proximal region DNA binding (GO:0001159) 3.822FEZF1, CHD7
macromolecular complex binding (GO:0044877) 2.612CHD7, FGFR1
nucleic acid binding (GO:0003676) 1.442FEZF1, CHD7
DNA binding (GO:0003677) 1.922FEZF1, CHD7
G-protein coupled receptor binding (GO:0001664) 4.182KISS1, PROK2
enzyme inhibitor activity (GO:0004857) 3.782ANOS1, FLRT3
purine nucleoside binding (GO:0001883) 2.222CHD7, FGFR1
nucleoside binding (GO:0001882) 2.212CHD7, FGFR1
sulfur compound binding (GO:1901681) 4.322ANOS1, FGFR1
sequence-specific DNA binding (GO:0043565) 2.792FEZF1, CHD7
sequence-specific double-stranded DNA binding (GO:1990837) 3.22FEZF1, CHD7
peptide binding (GO:0042277) 4.222GNRHR, KISS1R
growth factor activity (GO:0008083) 4.662FGF8, FGF17
nucleotide binding (GO:0000166) 1.962CHD7, FGFR1
identical protein binding (GO:0042802) 2.632FGFR1, FLRT3
nucleoside phosphate binding (GO:1901265) 1.962CHD7, FGFR1
ribonucleoside binding (GO:0032549) 2.222CHD7, FGFR1
core promoter proximal region sequence-specific DNA binding (GO:0000987) 3.832FEZF1, CHD7
purine nucleotide binding (GO:0017076) 2.192CHD7, FGFR1
double-stranded DNA binding (GO:0003690) 3.092FEZF1, CHD7
ATP binding (GO:0005524) 2.432CHD7, FGFR1
protein homodimerization activity (GO:0042803) 3.162FGFR1, FLRT3
hydrolase activity (GO:0016787) 1.92CHD7, DUSP6
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978) 3.882FEZF1, CHD7
amide binding (GO:0033218) 4.142GNRHR, KISS1R
enzyme regulator activity (GO:0030234) 2.852ANOS1, FLRT3
regulatory region nucleic acid binding (GO:0001067) 3.032FEZF1, CHD7
small molecule binding (GO:0036094) 1.892CHD7, FGFR1
type 2 fibroblast growth factor receptor binding (GO:0005111) 8.132FGF8, FGF17
heparin binding (GO:0008201) 4.682ANOS1, FGFR1
transcription regulatory region DNA binding (GO:0044212) 3.032FEZF1, CHD7
adenyl ribonucleotide binding (GO:0032559) 2.412CHD7, FGFR1
adenyl nucleotide binding (GO:0030554) 2.42CHD7, FGFR1
type 1 fibroblast growth factor receptor binding (GO:0005105) 8.132FGF8, FGF17
glycosaminoglycan binding (GO:0005539) 4.422ANOS1, FGFR1
chemorepellent activity (GO:0045499) 6.442FLRT3, SEMA3A
transcription regulatory region sequence-specific DNA binding (GO:0000976) 3.242FEZF1, CHD7
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) 3.372FEZF1, CHD7
regulatory region DNA binding (GO:0000975) 3.032FEZF1, CHD7
purine ribonucleotide binding (GO:0032555) 2.22CHD7, FGFR1
protein dimerization activity (GO:0046983) 2.722FGFR1, FLRT3
purine ribonucleoside binding (GO:0032550) 2.222CHD7, FGFR1
ribonucleotide binding (GO:0032553) 2.192CHD7, FGFR1

NET-GE enrichment

Term New enriched termICP valueGenes
G-protein coupled peptide receptor activity (GO:0008528) -4.860.032TACR3, PROKR2, KISS1R, SEMA3A
neurotransmitter receptor activity (GO:0030594) NEW5.50.012PROKR2, TACR3, KISS1R
growth factor activity (GO:0008083) -4.660.047PROK2, GNRH1, FGF8, FGFR1, FGF17
peptide receptor activity (GO:0001653) -4.840.037TACR3, PROKR2, KISS1R, SEMA3A
chemorepellent activity (GO:0045499) -6.440.0FGFR1, FLRT3, SEMA3A
neuropeptide receptor activity (GO:0008188) -5.950.016PROKR2, TACR3, KISS1R
receptor binding (GO:0005102) -2.430.002FSHB, GNRH1, FGF8, SEMA3A, KISS1, FGF17, LHB, PROK2, TAC3
fibroblast growth factor receptor binding (GO:0005104) -6.410.045FGF8, FGFR1, FGF17
type 1 fibroblast growth factor receptor binding (GO:0005105) -8.130.002FGF8, FGFR1, FGF17
type 2 fibroblast growth factor receptor binding (GO:0005111) -8.130.002FGF8, FGF17
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
biological regulation (GO:0065007) 0.3922IL17RD, FSHB, KISS1, SEMA3A, PROK2, GNRHR, SPRY4, FLRT3, DUSP6, TAC3, ANOS1, NSMF, FGF8, PROKR2, FGF17, FEZF1, GNRH1, CHD7, KISS1R, TACR3, LHB, FGFR1
regulation of biological process (GO:0050789) 0.4522IL17RD, FSHB, KISS1, SEMA3A, PROK2, GNRHR, SPRY4, FLRT3, DUSP6, TAC3, ANOS1, NSMF, FGF8, PROKR2, FGF17, FEZF1, GNRH1, CHD7, KISS1R, TACR3, LHB, FGFR1
regulation of cellular process (GO:0050794) 0.522IL17RD, FSHB, KISS1, SEMA3A, PROK2, GNRHR, SPRY4, FLRT3, DUSP6, TAC3, ANOS1, NSMF, FGF8, PROKR2, FGF17, FEZF1, GNRH1, CHD7, KISS1R, TACR3, LHB, FGFR1
single-organism process (GO:0044699) 0.4820ANOS1, FEZF1, GNRHR, GNRH1, FGF8, IL17RD, PROK2, SPRY4, CHD7, KISS1R, FGFR1, KISS1, SEMA3A, FLRT3, LHB, FSHB, HS6ST1, DUSP6, TACR3, FGF17
cellular process (GO:0009987) 0.2618ANOS1, FEZF1, IL17RD, GNRH1, FSHB, PROK2, FGF8, CHD7, SEMA3A, KISS1, FGF17, NSMF, FLRT3, LHB, HS6ST1, DUSP6, FGFR1, GNRHR
signal transduction (GO:0007165) 1.2817ANOS1, GNRHR, FGF17, FSHB, IL17RD, DUSP6, GNRH1, FGF8, KISS1R, FGFR1, TACR3, SEMA3A, FLRT3, LHB, PROKR2, PROK2, TAC3
single-organism cellular process (GO:0044763) 0.6516FEZF1, ANOS1, IL17RD, FSHB, FGF8, DUSP6, GNRH1, CHD7, SEMA3A, FGFR1, KISS1, FLRT3, LHB, HS6ST1, PROK2, FGF17
single-organism developmental process (GO:0044767) 1.4915FEZF1, FGF8, FGF17, FSHB, SPRY4, GNRH1, TACR3, SEMA3A, FGFR1, CHD7, FLRT3, LHB, HS6ST1, PROK2, GNRHR
developmental process (GO:0032502) 1.3615FEZF1, TACR3, GNRHR, FSHB, SPRY4, GNRH1, CHD7, SEMA3A, FGFR1, FGF8, FLRT3, LHB, HS6ST1, PROK2, FGF17
regulation of metabolic process (GO:0019222) 1.0215FEZF1, ANOS1, FGF8, FSHB, GNRH1, SPRY4, CHD7, KISS1R, FGFR1, KISS1, NSMF, FLRT3, DUSP6, PROK2, TACR3
positive regulation of biological process (GO:0048518) 1.214FEZF1, TACR3, FGF8, FSHB, DUSP6, CHD7, KISS1R, FGFR1, KISS1, NSMF, SEMA3A, FLRT3, PROK2, FGF17
regulation of macromolecule metabolic process (GO:0060255) 1.0814ANOS1, FEZF1, FGF8, FSHB, GNRH1, SPRY4, CHD7, KISS1R, FGFR1, KISS1, NSMF, FLRT3, DUSP6, PROK2
multicellular organismal process (GO:0032501) 1.4514FEZF1, GNRHR, FGF17, FSHB, GNRH1, SPRY4, FGF8, SEMA3A, FGFR1, CHD7, FLRT3, DUSP6, PROK2, TAC3
regulation of cellular metabolic process (GO:0031323) 1.0714FEZF1, ANOS1, FSHB, FGF8, DUSP6, SPRY4, CHD7, KISS1R, FGFR1, KISS1, NSMF, FLRT3, PROK2, TACR3
regulation of primary metabolic process (GO:0080090) 1.0814FEZF1, ANOS1, FGF8, FSHB, DUSP6, SPRY4, CHD7, KISS1R, FGFR1, KISS1, NSMF, FLRT3, PROK2, TACR3
anatomical structure development (GO:0048856) 1.5813FEZF1, FSHB, GNRH1, SPRY4, FGF8, SEMA3A, FGFR1, CHD7, FLRT3, LHB, HS6ST1, FGF17, GNRHR
regulation of multicellular organismal process (GO:0051239) 1.8713FEZF1, TACR3, FGF8, FSHB, DUSP6, GNRH1, CHD7, SEMA3A, FGFR1, KISS1, NSMF, FLRT3, PROK2
negative regulation of biological process (GO:0048519) 1.3312FEZF1, ANOS1, GNRH1, SPRY4, FGF8, KISS1R, FGFR1, KISS1, SEMA3A, FLRT3, DUSP6, PROK2
negative regulation of cellular process (GO:0048523) 1.4112FEZF1, ANOS1, GNRH1, SPRY4, KISS1, KISS1R, FGFR1, FGF8, SEMA3A, FLRT3, DUSP6, PROK2
positive regulation of cellular process (GO:0048522) 1.312FEZF1, FSHB, DUSP6, FGF8, KISS1R, FGFR1, KISS1, NSMF, SEMA3A, FLRT3, PROK2, FGF17
single-multicellular organism process (GO:0044707) 1.7811FEZF1, FGF17, SPRY4, GNRH1, FGF8, FLRT3, FGFR1, CHD7, SEMA3A, DUSP6, GNRHR
regulation of developmental process (GO:0050793) 2.111FEZF1, FSHB, DUSP6, GNRH1, CHD7, SEMA3A, FGFR1, FGF8, NSMF, FLRT3, PROK2
positive regulation of multicellular organismal process (GO:0051240) 2.4911FEZF1, TACR3, FGF8, FSHB, FGFR1, CHD7, SEMA3A, KISS1, NSMF, FLRT3, PROK2
regulation of multicellular organismal development (GO:2000026) 2.3111FEZF1, FSHB, DUSP6, GNRH1, CHD7, SEMA3A, FGFR1, FGF8, NSMF, FLRT3, PROK2
regulation of signaling (GO:0023051) 1.7211FGF8, DUSP6, SPRY4, CHD7, NSMF, FGFR1, KISS1, KISS1R, FLRT3, PROK2, FGF17
regulation of cell communication (GO:0010646) 1.7311SPRY4, CHD7, KISS1, NSMF, FGFR1, FGF8, KISS1R, FLRT3, DUSP6, PROK2, FGF17
regulation of cellular protein metabolic process (GO:0032268) 1.9910ANOS1, DUSP6, SPRY4, FGF8, NSMF, FGFR1, KISS1, KISS1R, FLRT3, PROK2
regulation of protein metabolic process (GO:0051246) 1.9310ANOS1, DUSP6, SPRY4, FGF8, NSMF, FGFR1, KISS1, KISS1R, FLRT3, PROK2
regulation of response to stimulus (GO:0048583) 1.5410DUSP6, SPRY4, FGF8, KISS1R, FGFR1, KISS1, SEMA3A, FLRT3, PROK2, FGF17
cellular metabolic process (GO:0044237) 0.6910FEZF1, IL17RD, FSHB, FGFR1, CHD7, FGF8, LHB, HS6ST1, DUSP6, FGF17
macromolecule metabolic process (GO:0043170) 0.8310FEZF1, IL17RD, FSHB, FGFR1, CHD7, FGF8, LHB, HS6ST1, DUSP6, FGF17
organic substance metabolic process (GO:0071704) 0.6310FEZF1, IL17RD, FSHB, FGFR1, CHD7, FGF8, LHB, HS6ST1, DUSP6, FGF17
metabolic process (GO:0008152) 0.5810FEZF1, IL17RD, FSHB, FGFR1, CHD7, FGF8, LHB, HS6ST1, DUSP6, FGF17
multicellular organism development (GO:0007275) 2.5410FEZF1, GNRH1, SPRY4, FGF8, SEMA3A, FGFR1, CHD7, FLRT3, FGF17, GNRHR
regulation of cell proliferation (GO:0042127) 2.419FEZF1, FSHB, FGFR1, GNRH1, FGF8, KISS1R, KISS1, PROK2, FGF17
primary metabolic process (GO:0044238) 0.699FEZF1, IL17RD, FSHB, FGFR1, CHD7, FGF8, LHB, DUSP6, FGF17
regulation of biological quality (GO:0065008) 1.689TACR3, FSHB, CHD7, KISS1R, KISS1, NSMF, SEMA3A, LHB, PROK2
regulation of phosphate metabolic process (GO:0019220) 2.359DUSP6, SPRY4, FGF8, NSMF, FGFR1, KISS1, KISS1R, FLRT3, PROK2
positive regulation of metabolic process (GO:0009893) 1.749FEZF1, FSHB, DUSP6, FGF8, NSMF, FGFR1, KISS1, KISS1R, PROK2
regulation of signal transduction (GO:0009966) 1.849DUSP6, SPRY4, FGF8, KISS1R, FGFR1, KISS1, FLRT3, PROK2, FGF17
positive regulation of cellular metabolic process (GO:0031325) 1.819FEZF1, FSHB, DUSP6, FGF8, NSMF, FGFR1, KISS1, KISS1R, PROK2
regulation of catalytic activity (GO:0050790) 1.979ANOS1, DUSP6, SPRY4, FLRT3, FGFR1, FGF8, KISS1R, PROK2, FGF17
regulation of phosphorus metabolic process (GO:0051174) 2.359DUSP6, SPRY4, FGF8, NSMF, FGFR1, KISS1, KISS1R, FLRT3, PROK2
reproductive process (GO:0022414) 2.559FSHB, GNRH1, CHD7, KISS1, FGF8, LHB, HS6ST1, PROK2, TAC3
cell surface receptor signaling pathway (GO:0007166) 2.099ANOS1, IL17RD, FSHB, SEMA3A, FGF8, FLRT3, PROKR2, FGFR1, FGF17
regulation of protein modification process (GO:0031399) 2.329DUSP6, SPRY4, FGF8, NSMF, FGFR1, KISS1, KISS1R, FLRT3, PROK2
regulation of molecular function (GO:0065009) 1.789ANOS1, DUSP6, SPRY4, FLRT3, FGFR1, FGF8, KISS1R, PROK2, FGF17
regulation of intracellular signal transduction (GO:1902531) 2.319DUSP6, SPRY4, FGF8, KISS1R, FGFR1, KISS1, FLRT3, PROK2, FGF17
positive regulation of macromolecule metabolic process (GO:0010604) 1.819FEZF1, FSHB, DUSP6, FGF8, NSMF, FGFR1, KISS1, KISS1R, PROK2
regulation of phosphorylation (GO:0042325) 2.58DUSP6, SPRY4, FGF8, KISS1R, FGFR1, KISS1, FLRT3, PROK2
organic substance biosynthetic process (GO:1901576) 1.348FEZF1, FSHB, FGF8, CHD7, LHB, HS6ST1, FGFR1, FGF17
single organism reproductive process (GO:0044702) 2.738FSHB, GNRH1, CHD7, KISS1, FGF8, LHB, HS6ST1, PROK2
cellular macromolecule metabolic process (GO:0044260) 0.938FEZF1, IL17RD, FGFR1, FGF8, CHD7, HS6ST1, DUSP6, FGF17
response to stimulus (GO:0050896) 1.228DUSP6, GNRH1, TACR3, FLRT3, FGF8, NSMF, PROK2, GNRHR
regulation of cell differentiation (GO:0045595) 2.428FEZF1, FSHB, FGFR1, GNRH1, NSMF, CHD7, SEMA3A, DUSP6
regulation of protein phosphorylation (GO:0001932) 2.578DUSP6, SPRY4, FGF8, KISS1R, FGFR1, KISS1, FLRT3, PROK2
cellular biosynthetic process (GO:0044249) 1.378FEZF1, FSHB, FGF8, CHD7, LHB, HS6ST1, FGFR1, FGF17
biosynthetic process (GO:0009058) 1.328FEZF1, FSHB, FGF8, CHD7, LHB, HS6ST1, FGFR1, FGF17
regulation of localization (GO:0032879) 1.948FSHB, GNRH1, CHD7, NSMF, KISS1, KISS1R, SEMA3A, FGFR1
locomotion (GO:0040011) 2.917FEZF1, ANOS1, FGFR1, FLRT3, FGF8, SEMA3A, PROK2
animal organ development (GO:0048513) 2.537FGF8, FLRT3, CHD7, SEMA3A, LHB, HS6ST1, FGFR1
single-organism metabolic process (GO:0044710) 1.637IL17RD, FSHB, FGFR1, FGF8, LHB, DUSP6, FGF17
positive regulation of phosphate metabolic process (GO:0045937) 2.787PROK2, KISS1, NSMF, FGFR1, FGF8, KISS1R, DUSP6
positive regulation of developmental process (GO:0051094) 2.777FEZF1, FGF8, NSMF, CHD7, SEMA3A, FLRT3, FGFR1
protein metabolic process (GO:0019538) 1.457IL17RD, FSHB, FGFR1, FGF8, LHB, DUSP6, FGF17
cellular developmental process (GO:0048869) 1.827FEZF1, FGFR1, FGF8, SEMA3A, CHD7, HS6ST1, DUSP6
positive regulation of phosphorus metabolic process (GO:0010562) 2.787PROK2, KISS1, NSMF, FGFR1, FGF8, KISS1R, DUSP6
positive regulation of protein modification process (GO:0031401) 2.77PROK2, KISS1, NSMF, FGFR1, FGF8, KISS1R, DUSP6
positive regulation of protein metabolic process (GO:0051247) 2.437PROK2, KISS1, NSMF, FGFR1, FGF8, KISS1R, DUSP6
regulation of nervous system development (GO:0051960) 3.17FEZF1, GNRH1, NSMF, CHD7, SEMA3A, FLRT3, FGFR1
positive regulation of cellular protein metabolic process (GO:0032270) 2.497PROK2, KISS1, NSMF, FGFR1, FGF8, KISS1R, DUSP6
G-protein coupled receptor signaling pathway (GO:0007186) 2.647FSHB, KISS1R, TACR3, TAC3, PROKR2, PROK2, GNRHR
regulation of MAPK cascade (GO:0043408) 3.227PROK2, SPRY4, FGF8, KISS1R, KISS1, FGFR1, DUSP6
negative regulation of metabolic process (GO:0009892) 1.936FEZF1, ANOS1, FGFR1, SPRY4, FLRT3, DUSP6
regulation of anatomical structure morphogenesis (GO:0022603) 2.796PROK2, NSMF, FGFR1, FGF8, SEMA3A, DUSP6
positive regulation of response to stimulus (GO:0048584) 2.186PROK2, FGF8, KISS1R, KISS1, FGFR1, DUSP6
negative regulation of cellular metabolic process (GO:0031324) 2.016FEZF1, ANOS1, FGFR1, SPRY4, FLRT3, DUSP6
regulation of cellular component organization (GO:0051128) 2.016NSMF, FGF8, KISS1R, FLRT3, SEMA3A, FGFR1
positive regulation of signaling (GO:0023056) 2.416PROK2, FGF8, KISS1R, KISS1, FGFR1, DUSP6
nitrogen compound metabolic process (GO:0006807) 1.136FEZF1, FSHB, CHD7, LHB, HS6ST1, FGFR1
cellular component organization (GO:0016043) 1.246CHD7, FGF8, SEMA3A, KISS1, FLRT3, FGFR1
enzyme linked receptor protein signaling pathway (GO:0007167) 3.246ANOS1, FSHB, FLRT3, FGF8, FGFR1, FGF17
positive regulation of cell communication (GO:0010647) 2.416PROK2, FGF8, KISS1R, KISS1, FGFR1, DUSP6
regulation of cell death (GO:0010941) 2.436PROK2, GNRH1, NSMF, FGF8, FGFR1, DUSP6
regulation of apoptotic process (GO:0042981) 2.56PROK2, GNRH1, NSMF, FGF8, FGFR1, DUSP6
intracellular signal transduction (GO:0035556) 2.396IL17RD, DUSP6, KISS1R, FGF8, FGFR1, FGF17
cellular component organization or biogenesis (GO:0071840) 1.226CHD7, FGF8, SEMA3A, KISS1, FLRT3, FGFR1
regulation of neurogenesis (GO:0050767) 3.216FEZF1, GNRH1, NSMF, CHD7, SEMA3A, FGFR1
negative regulation of macromolecule metabolic process (GO:0010605) 2.016FEZF1, ANOS1, FGFR1, SPRY4, FLRT3, DUSP6
positive regulation of signal transduction (GO:0009967) 2.56PROK2, FGF8, KISS1R, KISS1, FGFR1, DUSP6
regulation of kinase activity (GO:0043549) 3.076PROK2, SPRY4, FLRT3, FGFR1, KISS1R, DUSP6
regulation of cell development (GO:0060284) 3.016FEZF1, GNRH1, NSMF, CHD7, SEMA3A, FGFR1
regulation of programmed cell death (GO:0043067) 2.496PROK2, GNRH1, NSMF, FGF8, FGFR1, DUSP6
positive regulation of catalytic activity (GO:0043085) 2.46PROK2, KISS1R, FGF8, FGFR1, DUSP6, FGF17
positive regulation of molecular function (GO:0044093) 2.236PROK2, KISS1R, FGF8, FGFR1, DUSP6, FGF17
regulation of gene expression (GO:0010468) 1.376FEZF1, FSHB, GNRH1, FGF8, CHD7, FGFR1
cell differentiation (GO:0030154) 2.146FEZF1, DUSP6, FGF8, SEMA3A, CHD7, FGFR1
regulation of protein kinase activity (GO:0045859) 3.156PROK2, SPRY4, FLRT3, FGFR1, KISS1R, DUSP6
positive regulation of MAPK cascade (GO:0043410) 3.576PROK2, FGF8, KISS1R, KISS1, FGFR1, DUSP6
developmental process involved in reproduction (GO:0003006) 3.366FSHB, GNRH1, CHD7, FGF8, LHB, HS6ST1
regulation of nitrogen compound metabolic process (GO:0051171) 1.366FEZF1, FSHB, FGF8, CHD7, TACR3, FGFR1
response to chemical (GO:0042221) 1.986GNRH1, TACR3, NSMF, FGF8, DUSP6, GNRHR
positive regulation of intracellular signal transduction (GO:1902533) 2.956PROK2, FGF8, KISS1R, KISS1, FGFR1, DUSP6
movement of cell or subcellular component (GO:0006928) 2.616FEZF1, ANOS1, FLRT3, FGF8, SEMA3A, FGFR1
response to organic substance (GO:0010033) 2.26GNRH1, TACR3, NSMF, FGF8, DUSP6, GNRHR
positive regulation of phosphorylation (GO:0042327) 2.96PROK2, FGF8, KISS1R, KISS1, FGFR1, DUSP6
regulation of transferase activity (GO:0051338) 2.886PROK2, SPRY4, FLRT3, FGFR1, KISS1R, DUSP6
system development (GO:0048731) 2.926FEZF1, FGF8, SEMA3A, CHD7, FGFR1, FGF17
positive regulation of protein phosphorylation (GO:0001934) 2.956PROK2, FGF8, KISS1R, KISS1, FGFR1, DUSP6
regulation of developmental growth (GO:0048638) 4.045FGFR1, FGF8, DUSP6, CHD7, SEMA3A
MAPK cascade (GO:0000165) 3.915FGFR1, IL17RD, DUSP6, FGF8, FGF17
regulation of MAP kinase activity (GO:0043405) 3.955PROK2, SPRY4, DUSP6, FGFR1, KISS1R
axon guidance (GO:0007411) 4.445ANOS1, FEZF1, FGF8, FLRT3, SEMA3A
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.545ANOS1, FGF8, FGFR1, FGF17, FLRT3
regulation of protein serine/threonine kinase activity (GO:0071900) 3.585PROK2, DUSP6, SPRY4, FGFR1, KISS1R
organic cyclic compound biosynthetic process (GO:1901362) 1.665FEZF1, LHB, CHD7, FGFR1, FSHB
organic cyclic compound metabolic process (GO:1901360) 1.265FEZF1, LHB, CHD7, FGFR1, FSHB
chemotaxis (GO:0006935) 4.045ANOS1, FGF8, PROK2, FLRT3, SEMA3A
cellular protein metabolic process (GO:0044267) 1.635DUSP6, IL17RD, FGFR1, FGF8, FGF17
single-organism biosynthetic process (GO:0044711) 2.85LHB, FGF8, FGFR1, FGF17, FSHB
regulation of system process (GO:0044057) 3.535PROK2, KISS1, FGFR1, TACR3, SEMA3A
regulation of transcription, DNA-templated (GO:0006355) 1.565FEZF1, FGF8, FGFR1, CHD7, FSHB
anatomical structure morphogenesis (GO:0009653) 2.535FGF8, CHD7, FGFR1, FLRT3, SEMA3A
fibroblast growth factor receptor signaling pathway (GO:0008543) 5.35ANOS1, FGF8, FGFR1, FGF17, FLRT3
regulation of growth (GO:0040008) 3.265DUSP6, CHD7, FGFR1, FGF8, SEMA3A
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.465FEZF1, CHD7, FGFR1, FGF8, FSHB
rhythmic process (GO:0048511) 4.025PROK2, PROKR2, GNRH1, KISS1, FSHB
signal transduction by protein phosphorylation (GO:0023014) 3.795DUSP6, FGF8, FGFR1, IL17RD, FGF17
protein modification process (GO:0036211) 1.795DUSP6, IL17RD, FGFR1, FGF8, FGF17
phosphorylation (GO:0016310) 2.635FGFR1, IL17RD, DUSP6, FGF8, FGF17
cell migration (GO:0016477) 3.125FEZF1, FGF8, FGFR1, FLRT3, SEMA3A
positive regulation of cell proliferation (GO:0008284) 3.015PROK2, FGF8, FGFR1, FSHB, FGF17
protein phosphorylation (GO:0006468) 2.895FGFR1, IL17RD, DUSP6, FGF8, FGF17
regulation of cell migration (GO:0030334) 3.235GNRH1, FSHB, FGFR1, SEMA3A, NSMF
reproductive structure development (GO:0048608) 4.085LHB, CHD7, FGF8, HS6ST1, FSHB
lipid metabolic process (GO:0006629) 2.685LHB, FGF8, FGFR1, FGF17, FSHB
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.435FEZF1, FGF8, FGFR1, CHD7, FSHB
regulation of biosynthetic process (GO:0009889) 1.375FEZF1, CHD7, FGFR1, FGF8, FSHB
cellular protein modification process (GO:0006464) 1.795FGFR1, IL17RD, DUSP6, FGF8, FGF17
regulation of hormone levels (GO:0010817) 3.565LHB, FSHB, KISS1, CHD7, KISS1R
regulation of cellular biosynthetic process (GO:0031326) 1.385FEZF1, FGF8, FGFR1, CHD7, FSHB
macromolecule modification (GO:0043412) 1.735DUSP6, IL17RD, FGFR1, FGF8, FGF17
regulation of locomotion (GO:0040012) 3.125FGFR1, FSHB, GNRH1, NSMF, SEMA3A
regulation of nucleic acid-templated transcription (GO:1903506) 1.555FEZF1, CHD7, FGFR1, FGF8, FSHB
regulation of RNA biosynthetic process (GO:2001141) 1.555FEZF1, FGF8, FGFR1, CHD7, FSHB
cellular nitrogen compound metabolic process (GO:0034641) 1.225FEZF1, LHB, CHD7, FGFR1, FSHB
neuron projection guidance (GO:0097485) 4.435ANOS1, FEZF1, FGF8, FLRT3, SEMA3A
lipid biosynthetic process (GO:0008610) 3.495LHB, FGF8, FGFR1, FSHB, FGF17
regulation of cellular component movement (GO:0051270) 3.085GNRH1, FSHB, FGFR1, NSMF, SEMA3A
taxis (GO:0042330) 4.035ANOS1, FGF8, PROK2, FLRT3, SEMA3A
cell motility (GO:0048870) 3.025FEZF1, FGF8, FGFR1, FLRT3, SEMA3A
regulation of RNA metabolic process (GO:0051252) 1.525FEZF1, FGF8, FGFR1, CHD7, FSHB
response to stress (GO:0006950) 1.85PROK2, FGF8, DUSP6, TACR3, FLRT3
positive regulation of nervous system development (GO:0051962) 3.645FEZF1, FGFR1, NSMF, SEMA3A, FLRT3
phosphate-containing compound metabolic process (GO:0006796) 2.165FGFR1, IL17RD, DUSP6, FGF8, FGF17
regulation of macromolecule biosynthetic process (GO:0010556) 1.435FEZF1, CHD7, FGFR1, FGF8, FSHB
regulation of cell motility (GO:2000145) 3.165GNRH1, FSHB, FGFR1, SEMA3A, NSMF
phosphorus metabolic process (GO:0006793) 2.155DUSP6, FGF8, FGFR1, IL17RD, FGF17
positive regulation of cellular component organization (GO:0051130) 2.684FGF8, FGFR1, FLRT3, KISS1R
positive regulation of kinase activity (GO:0033674) 3.544DUSP6, PROK2, FGFR1, KISS1R
negative regulation of response to stimulus (GO:0048585) 2.524SPRY4, DUSP6, FLRT3, SEMA3A
signaling (GO:0023052) 3.254LHB, FGFR1, GNRH1, FGF17
cellular macromolecule biosynthetic process (GO:0034645) 1.664FEZF1, HS6ST1, FGFR1, CHD7
regulation of hydrolase activity (GO:0051336) 2.534ANOS1, FGF8, FGFR1, FGF17
response to organic cyclic compound (GO:0014070) 3.074GNRH1, TACR3, DUSP6, FGF8
response to endogenous stimulus (GO:0009719) 2.794TACR3, GNRH1, GNRHR, NSMF
negative regulation of protein metabolic process (GO:0051248) 2.824ANOS1, SPRY4, DUSP6, FLRT3
positive regulation of transferase activity (GO:0051347) 3.314DUSP6, PROK2, FGFR1, KISS1R
negative regulation of multicellular organismal process (GO:0051241) 2.844FGFR1, FGF8, GNRH1, SEMA3A
positive regulation of neurogenesis (GO:0050769) 3.774FEZF1, FGFR1, SEMA3A, NSMF
regulation of neuron differentiation (GO:0045664) 3.394FEZF1, FGFR1, NSMF, SEMA3A
positive regulation of cell development (GO:0010720) 3.574FEZF1, FGFR1, SEMA3A, NSMF
negative regulation of molecular function (GO:0044092) 2.744ANOS1, SPRY4, DUSP6, FLRT3
anatomical structure formation involved in morphogenesis (GO:0048646) 3.014FGFR1, HS6ST1, PROK2, FGF8
embryonic morphogenesis (GO:0048598) 3.724CHD7, FGFR1, FGF8, FLRT3
negative regulation of cell proliferation (GO:0008285) 3.264FEZF1, KISS1, GNRH1, KISS1R
positive regulation of cell migration (GO:0030335) 3.774FSHB, FGFR1, SEMA3A, NSMF
single organism signaling (GO:0044700) 3.254LHB, FGFR1, GNRH1, FGF17
neuropeptide signaling pathway (GO:0007218) 5.134PROKR2, PROK2, TAC3, KISS1R
tissue development (GO:0009888) 3.274CHD7, FGFR1, FGF8, SEMA3A
positive regulation of cell differentiation (GO:0045597) 3.014FEZF1, FGFR1, SEMA3A, NSMF
macromolecule biosynthetic process (GO:0009059) 1.614FEZF1, HS6ST1, FGFR1, CHD7
cell-cell signaling (GO:0007267) 3.354LHB, GNRH1, FGFR1, FGF17
cell communication (GO:0007154) 3.044LHB, FGFR1, GNRH1, FGF17
response to oxygen-containing compound (GO:1901700) 2.574TACR3, GNRH1, GNRHR, NSMF
positive regulation of cellular component movement (GO:0051272) 3.714FSHB, FGFR1, NSMF, SEMA3A
negative regulation of cellular protein metabolic process (GO:0032269) 2.884ANOS1, SPRY4, DUSP6, FLRT3
positive regulation of locomotion (GO:0040017) 3.714FSHB, FGFR1, SEMA3A, NSMF
response to organonitrogen compound (GO:0010243) 3.24TACR3, GNRH1, GNRHR, NSMF
negative regulation of catalytic activity (GO:0043086) 3.04ANOS1, SPRY4, DUSP6, FLRT3
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.244FEZF1, FGF8, FGFR1, FSHB
positive regulation of cell motility (GO:2000147) 3.744FSHB, FGFR1, SEMA3A, NSMF
positive regulation of protein kinase activity (GO:0045860) 3.614PROK2, DUSP6, FGFR1, KISS1R
response to nitrogen compound (GO:1901698) 3.124TACR3, GNRH1, GNRHR, NSMF
limb morphogenesis (GO:0035108) 5.053CHD7, FGFR1, FGF8
regulation of secretion (GO:0051046) 3.23KISS1, CHD7, KISS1R
regulation of transport (GO:0051049) 2.243KISS1, CHD7, KISS1R
appendage morphogenesis (GO:0035107) 5.053FGF8, FGFR1, CHD7
activation of protein kinase activity (GO:0032147) 4.083PROK2, DUSP6, KISS1R
regulation of cell projection organization (GO:0031344) 3.383FGFR1, SEMA3A, NSMF
morphogenesis of an epithelium (GO:0002009) 4.083FGF8, FGFR1, SEMA3A
negative regulation of signal transduction (GO:0009968) 2.753SPRY4, DUSP6, FLRT3
peptidyl-tyrosine modification (GO:0018212) 4.473FGF8, FGFR1, FGF17
peptidyl-amino acid modification (GO:0018193) 2.983FGF8, FGFR1, FGF17
blood vessel morphogenesis (GO:0048514) 5.323CHD7, FGFR1, FGF8
phosphatidylinositol biosynthetic process (GO:0006661) 4.943FGF8, FGFR1, FGF17
system process (GO:0003008) 2.33FGFR1, CHD7, PROK2
negative regulation of cell death (GO:0060548) 2.953PROK2, FGF8, GNRH1
sensory perception (GO:0007600) 2.933PROK2, CHD7, FGFR1
phosphatidylinositol metabolic process (GO:0046488) 4.463FGF8, FGFR1, FGF17
regionalization (GO:0003002) 4.243FEZF1, FGF8, DUSP6
regulation of neuron projection development (GO:0010975) 3.693FGFR1, NSMF, SEMA3A
glycerolipid metabolic process (GO:0046486) 3.913FGF8, FGFR1, FGF17
multi-organism process (GO:0051704) 2.653GNRH1, FSHB, TAC3
multi-organism reproductive process (GO:0044703) 4.823GNRH1, FSHB, TAC3
negative regulation of phosphorylation (GO:0042326) 3.73SPRY4, DUSP6, FLRT3
organonitrogen compound metabolic process (GO:1901564) 2.323LHB, HS6ST1, FSHB
positive regulation of MAP kinase activity (GO:0043406) 4.393DUSP6, FGFR1, PROK2
multi-multicellular organism process (GO:0044706) 4.923GNRH1, FSHB, TAC3
response to hormone (GO:0009725) 3.333GNRH1, GNRHR, NSMF
organophosphate metabolic process (GO:0019637) 3.043FGF8, FGFR1, FGF17
aromatic compound biosynthetic process (GO:0019438) 1.73FEZF1, CHD7, FGFR1
negative regulation of cell communication (GO:0010648) 2.663SPRY4, DUSP6, FLRT3
negative regulation of kinase activity (GO:0033673) 4.223SPRY4, DUSP6, FLRT3
positive regulation of gene expression (GO:0010628) 2.353FEZF1, FGF8, FSHB
neuron migration (GO:0001764) 5.03FEZF1, FGFR1, SEMA3A
positive regulation of protein serine/threonine kinase activity (GO:0071902) 4.063PROK2, DUSP6, FGFR1
nucleic acid-templated transcription (GO:0097659) 1.913FEZF1, CHD7, FGFR1
positive regulation of GTPase activity (GO:0043547) 3.283FGF8, FGFR1, FGF17
positive regulation of hydrolase activity (GO:0051345) 2.913FGF8, FGFR1, FGF17
heterocycle metabolic process (GO:0046483) 1.313FEZF1, CHD7, FGFR1
negative regulation of transferase activity (GO:0051348) 3.873SPRY4, DUSP6, FLRT3
phosphatidylinositol phosphorylation (GO:0046854) 5.193FGF8, FGFR1, FGF17
regulation of neuron migration (GO:2001222) 6.363GNRH1, NSMF, SEMA3A
negative regulation of intracellular signal transduction (GO:1902532) 3.633SPRY4, DUSP6, FLRT3
heterocycle biosynthetic process (GO:0018130) 1.73FEZF1, CHD7, FGFR1
organ morphogenesis (GO:0009887) 3.553CHD7, FGFR1, FGF8
cell development (GO:0048468) 3.283HS6ST1, FGFR1, FGF8
pattern specification process (GO:0007389) 3.793FEZF1, FGF8, DUSP6
nucleobase-containing compound biosynthetic process (GO:0034654) 1.723FEZF1, CHD7, FGFR1
organophosphate biosynthetic process (GO:0090407) 3.673FGF8, FGFR1, FGF17
inositol lipid-mediated signaling (GO:0048017) 4.913FGF8, FGFR1, FGF17
RNA metabolic process (GO:0016070) 1.593FEZF1, CHD7, FGFR1
cellular nitrogen compound biosynthetic process (GO:0044271) 1.593FEZF1, CHD7, FGFR1
phospholipid biosynthetic process (GO:0008654) 4.393FGF8, FGFR1, FGF17
negative regulation of protein modification process (GO:0031400) 3.43SPRY4, DUSP6, FLRT3
transcription, DNA-templated (GO:0006351) 1.913FEZF1, CHD7, FGFR1
positive regulation of developmental growth (GO:0048639) 4.673FGF8, FGFR1, CHD7
RNA biosynthetic process (GO:0032774) 1.843FEZF1, CHD7, FGFR1
modulation of synaptic transmission (GO:0050804) 4.093KISS1, KISS1R, NSMF
negative regulation of signaling (GO:0023057) 2.653SPRY4, DUSP6, FLRT3
embryo development ending in birth or egg hatching (GO:0009792) 4.353CHD7, FGFR1, FGF8
regulation of secretion by cell (GO:1903530) 3.283KISS1, CHD7, KISS1R
regulation of GTPase activity (GO:0043087) 3.213FGF8, FGFR1, FGF17
glycerophospholipid metabolic process (GO:0006650) 4.133FGF8, FGFR1, FGF17
nucleobase-containing compound metabolic process (GO:0006139) 1.353FEZF1, CHD7, FGFR1
phosphatidylinositol-mediated signaling (GO:0048015) 4.933FGF8, FGFR1, FGF17
negative regulation of phosphorus metabolic process (GO:0010563) 3.453SPRY4, DUSP6, FLRT3
lipid phosphorylation (GO:0046834) 5.133FGF8, FGFR1, FGF17
biological adhesion (GO:0022610) 2.813ANOS1, CHD7, FLRT3
phospholipid metabolic process (GO:0006644) 3.883FGF8, FGFR1, FGF17
multicellular organismal reproductive process (GO:0048609) 3.353GNRH1, PROK2, FSHB
cell proliferation (GO:0008283) 3.233FGF8, PROK2, FSHB
neurological system process (GO:0050877) 2.643FGFR1, CHD7, PROK2
epithelium development (GO:0060429) 4.573CHD7, FGFR1, FGF8
cellular aromatic compound metabolic process (GO:0006725) 1.33FEZF1, CHD7, FGFR1
negative regulation of cell differentiation (GO:0045596) 3.333GNRH1, FGFR1, SEMA3A
regulation of hormone secretion (GO:0046883) 4.183KISS1, CHD7, KISS1R
olfactory bulb development (GO:0021772) 6.683FEZF1, CHD7, SEMA3A
cellular lipid metabolic process (GO:0044255) 2.923FGF8, FGFR1, FGF17
regulation of phosphatidylinositol 3-kinase signaling (GO:0014066) 4.793FGF8, FGFR1, FGF17
lipid modification (GO:0030258) 4.373FGF8, FGFR1, FGF17
negative regulation of developmental process (GO:0051093) 3.173FGF8, GNRH1, SEMA3A
female pregnancy (GO:0007565) 5.083GNRH1, TAC3, FSHB
glycerophospholipid biosynthetic process (GO:0046474) 4.623FGF8, FGFR1, FGF17
embryo development (GO:0009790) 4.23FGF8, FGFR1, CHD7
regulation of ERK1 and ERK2 cascade (GO:0070372) 4.233DUSP6, FGF8, SPRY4
positive regulation of growth (GO:0045927) 4.253CHD7, FGFR1, FGF8
embryonic limb morphogenesis (GO:0030326) 5.243FGF8, FGFR1, CHD7
cell projection organization (GO:0030030) 3.143FGFR1, FLRT3, SEMA3A
peptidyl-tyrosine phosphorylation (GO:0018108) 4.483FGF8, FGFR1, FGF17
nucleic acid metabolic process (GO:0090304) 1.463FEZF1, CHD7, FGFR1
angiogenesis (GO:0001525) 4.153PROK2, HS6ST1, FGFR1
glycerolipid biosynthetic process (GO:0045017) 4.533FGF8, FGFR1, FGF17
negative regulation of apoptotic process (GO:0043066) 3.043GNRH1, FGF8, PROK2
tissue morphogenesis (GO:0048729) 3.873FGF8, FGFR1, SEMA3A
negative regulation of programmed cell death (GO:0043069) 3.023GNRH1, FGF8, PROK2
neuron development (GO:0048666) 4.83HS6ST1, FGFR1, FGF8
negative regulation of protein kinase activity (GO:0006469) 4.293SPRY4, DUSP6, FLRT3
negative regulation of phosphate metabolic process (GO:0045936) 3.453SPRY4, DUSP6, FLRT3
regulation of organ growth (GO:0046620) 5.413DUSP6, FGF8, FGFR1
phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) 5.843FGF8, FGFR1, FGF17
embryonic appendage morphogenesis (GO:0035113) 5.243FGF8, FGFR1, CHD7
cell adhesion (GO:0007155) 2.823ANOS1, CHD7, FLRT3
heart development (GO:0007507) 4.243CHD7, FGF8, FLRT3
inner ear morphogenesis (GO:0042472) 5.623FGF8, FGFR1, CHD7
nervous system development (GO:0007399) 3.533FEZF1, FGF17, SEMA3A
negative regulation of protein phosphorylation (GO:0001933) 3.793SPRY4, DUSP6, FLRT3
regulation of peptide transport (GO:0090087) 4.372KISS1, CHD7
cytokine-mediated signaling pathway (GO:0019221) 3.62IL17RD, FLRT3
developmental growth (GO:0048589) 4.052FLRT3, SEMA3A
positive regulation of secretion (GO:0051047) 3.852KISS1, KISS1R
regulation of reproductive process (GO:2000241) 4.882GNRH1, SEMA3A
skeletal system development (GO:0001501) 4.492CHD7, FGFR1
regulation of neuron apoptotic process (GO:0043523) 4.472FGF8, NSMF
regulation of chemotaxis (GO:0050920) 4.532FGFR1, SEMA3A
small molecule metabolic process (GO:0044281) 2.382LHB, FSHB
small molecule biosynthetic process (GO:0044283) 3.792LHB, FSHB
inorganic ion homeostasis (GO:0098771) 3.432KISS1, PROK2
positive regulation of smooth muscle contraction (GO:0045987) 6.292TACR3, PROK2
hormone metabolic process (GO:0042445) 4.642LHB, FSHB
cellular response to stimulus (GO:0051716) 1.972GNRHR, NSMF
C21-steroid hormone metabolic process (GO:0008207) 6.552LHB, FSHB
positive regulation of cell cycle (GO:0045787) 3.942FGF8, FGFR1
regulation of organ formation (GO:0003156) 6.262FGF8, FGFR1
developmental cell growth (GO:0048588) 5.372FLRT3, SEMA3A
progesterone metabolic process (GO:0042448) 7.092LHB, FSHB
tachykinin receptor signaling pathway (GO:0007217) 7.782TACR3, TAC3
positive regulation of neuron differentiation (GO:0045666) 3.982FEZF1, FGFR1
negative regulation of cell development (GO:0010721) 4.022GNRH1, SEMA3A
genitalia development (GO:0048806) 6.22CHD7, FGF8
cellular homeostasis (GO:0019725) 3.232KISS1, PROK2
regulation of striated muscle tissue development (GO:0016202) 5.092FGF8, FGFR1
neuron projection extension (GO:1990138) 5.742FLRT3, SEMA3A
regulation of muscle contraction (GO:0006937) 4.752TACR3, PROK2
sensory perception of sound (GO:0007605) 4.822CHD7, FGFR1
positive regulation of synaptic transmission (GO:0050806) 5.072KISS1, KISS1R
heart morphogenesis (GO:0003007) 5.842CHD7, FGF8
regulation of peptide hormone secretion (GO:0090276) 4.412KISS1, CHD7
organ induction (GO:0001759) 7.022FGF8, FGFR1
regulation of embryonic development (GO:0045995) 4.982FGFR1, DUSP6
response to peptide hormone (GO:0043434) 4.062GNRH1, GNRHR
transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0007178) 4.62FGF8, FSHB
regulation of epithelial cell migration (GO:0010632) 4.622FGFR1, SEMA3A
positive regulation of organelle organization (GO:0010638) 3.382FGF8, KISS1R
positive regulation of cytosolic calcium ion concentration (GO:0007204) 4.562KISS1, PROK2
chemical homeostasis (GO:0048878) 2.972KISS1, PROK2
calcium ion homeostasis (GO:0055074) 3.972KISS1, PROK2
telencephalon development (GO:0021537) 6.42FEZF1, FGF8
negative regulation of biosynthetic process (GO:0009890) 2.472FEZF1, FGFR1
positive regulation of biosynthetic process (GO:0009891) 2.292FEZF1, FSHB
progesterone biosynthetic process (GO:0006701) 7.942LHB, FSHB
negative regulation of gene expression (GO:0010629) 2.482FEZF1, FGFR1
morphogenesis of a branching structure (GO:0001763) 4.712FGF8, FGFR1
neuron projection development (GO:0031175) 4.582FGFR1, FLRT3
negative regulation of protein serine/threonine kinase activity (GO:0071901) 4.922SPRY4, DUSP6
developmental induction (GO:0031128) 6.592FGF8, FGFR1
cell growth (GO:0016049) 4.832FLRT3, SEMA3A
blood vessel development (GO:0001568) 4.952HS6ST1, CHD7
gonad development (GO:0008406) 4.922LHB, FGF8
regulation of immune system process (GO:0002682) 2.52GNRH1, FSHB
positive regulation of neuron migration (GO:2001224) 7.332NSMF, SEMA3A
regulation of muscle tissue development (GO:1901861) 5.072FGF8, FGFR1
circadian rhythm (GO:0007623) 4.792PROKR2, PROK2
cell-cell adhesion (GO:0098609) 3.342CHD7, FLRT3
sensory perception of mechanical stimulus (GO:0050954) 4.792CHD7, FGFR1
regulation of cardiac muscle tissue development (GO:0055024) 5.862FGF8, FGFR1
regulation of heart contraction (GO:0008016) 4.352TACR3, SEMA3A
hormone biosynthetic process (GO:0042446) 5.882LHB, FSHB
programmed cell death (GO:0012501) 3.12FGF8, SEMA3A
regulation of blood circulation (GO:1903522) 4.052TACR3, SEMA3A
regulation of neuron death (GO:1901214) 4.192FGF8, NSMF
cellular divalent inorganic cation homeostasis (GO:0072503) 3.962KISS1, PROK2
regulation of growth hormone secretion (GO:0060123) 7.242KISS1, CHD7
dorsal/ventral pattern formation (GO:0009953) 5.62FGF8, DUSP6
protein maturation (GO:0051604) 4.482LHB, FSHB
cellular response to nitrogen compound (GO:1901699) 3.792GNRHR, NSMF
negative regulation of nervous system development (GO:0051961) 4.152GNRH1, SEMA3A
steroid biosynthetic process (GO:0006694) 5.062LHB, FSHB
negative regulation of cell motility (GO:2000146) 4.362GNRH1, SEMA3A
peptide metabolic process (GO:0006518) 3.442LHB, FSHB
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532FEZF1, FGFR1
regulation of cell morphogenesis (GO:0022604) 3.42NSMF, SEMA3A
regulation of organelle organization (GO:0033043) 2.722FGF8, KISS1R
ion homeostasis (GO:0050801) 3.422KISS1, PROK2
metal ion homeostasis (GO:0055065) 3.612KISS1, PROK2
regulation of muscle organ development (GO:0048634) 5.072FGF8, FGFR1
negative regulation of MAP kinase activity (GO:0043407) 5.422SPRY4, DUSP6
regulation of smooth muscle contraction (GO:0006940) 5.632TACR3, PROK2
cellular response to chemical stimulus (GO:0070887) 2.572GNRHR, NSMF
positive regulation of secretion by cell (GO:1903532) 3.932KISS1, KISS1R
ameboidal-type cell migration (GO:0001667) 4.712FGF8, SEMA3A
tube development (GO:0035295) 4.412FGF8, FGFR1
negative regulation of MAPK cascade (GO:0043409) 4.742SPRY4, DUSP6
divalent inorganic cation homeostasis (GO:0072507) 3.92KISS1, PROK2
regulation of cellular response to growth factor stimulus (GO:0090287) 4.292FGFR1, DUSP6
in utero embryonic development (GO:0001701) 4.42CHD7, FGFR1
ovulation cycle process (GO:0022602) 5.252KISS1, FSHB
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122FEZF1, FGFR1
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392FEZF1, FSHB
negative regulation of neurogenesis (GO:0050768) 4.222GNRH1, SEMA3A
regulation of heart rate (GO:0002027) 5.292TACR3, SEMA3A
regulation of cell morphogenesis involved in differentiation (GO:0010769) 3.912NSMF, SEMA3A
branching involved in salivary gland morphogenesis (GO:0060445) 7.332FGF8, FGFR1
central nervous system neuron development (GO:0021954) 6.262FGF8, FGFR1
chordate embryonic development (GO:0043009) 4.382CHD7, FGFR1
developmental growth involved in morphogenesis (GO:0060560) 5.152FLRT3, SEMA3A
cellular response to endogenous stimulus (GO:0071495) 3.332GNRHR, NSMF
regulation of heart growth (GO:0060420) 5.972FGFR1, DUSP6
tube morphogenesis (GO:0035239) 4.352CHD7, FGF8
cellular response to oxygen-containing compound (GO:1901701) 3.222GNRHR, NSMF
cellular metal ion homeostasis (GO:0006875) 3.752KISS1, PROK2
cellular calcium ion homeostasis (GO:0006874) 4.012KISS1, PROK2
negative regulation of locomotion (GO:0040013) 4.222GNRH1, SEMA3A
cellular ion homeostasis (GO:0006873) 3.572KISS1, PROK2
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712FEZF1, FGFR1
cellular response to hormone stimulus (GO:0032870) 3.992GNRHR, NSMF
regulation of cell fate specification (GO:0042659) 7.162FGFR1, DUSP6
hindlimb morphogenesis (GO:0035137) 6.122CHD7, FGF8
cellular cation homeostasis (GO:0030003) 3.62KISS1, PROK2
positive regulation of hormone secretion (GO:0046887) 4.982KISS1, KISS1R
protein processing (GO:0016485) 4.622LHB, FSHB
nerve development (GO:0021675) 6.292CHD7, SEMA3A
cellular chemical homeostasis (GO:0055082) 3.42KISS1, PROK2
peptide hormone processing (GO:0016486) 6.292LHB, FSHB
proteolysis (GO:0006508) 2.732LHB, FSHB
steroid metabolic process (GO:0008202) 4.322LHB, FSHB
aging (GO:0007568) 4.162TACR3, GNRH1
cellular amide metabolic process (GO:0043603) 3.232LHB, FSHB
negative regulation of RNA metabolic process (GO:0051253) 2.662FEZF1, FGFR1
response to drug (GO:0042493) 3.712FGF8, DUSP6
positive regulation of RNA metabolic process (GO:0051254) 2.512FEZF1, FSHB
positive regulation of RNA biosynthetic process (GO:1902680) 2.542FEZF1, FSHB
regulation of gastrulation (GO:0010470) 6.172FGFR1, DUSP6
negative regulation of ERK1 and ERK2 cascade (GO:0070373) 5.742SPRY4, DUSP6
activation of MAPK activity (GO:0000187) 4.792PROK2, DUSP6
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562FEZF1, FSHB
lung development (GO:0030324) 5.132FGF8, FGFR1
positive regulation of cellular biosynthetic process (GO:0031328) 2.32FEZF1, FSHB
negative regulation of cellular biosynthetic process (GO:0031327) 2.492FEZF1, FGFR1
homeostatic process (GO:0042592) 2.612KISS1, PROK2
motor neuron axon guidance (GO:0008045) 6.42FGF8, SEMA3A
cell death (GO:0008219) 3.052FGF8, SEMA3A
gamete generation (GO:0007276) 3.612PROK2, FSHB
growth (GO:0040007) 3.82FLRT3, SEMA3A
response to lipid (GO:0033993) 3.112TACR3, GNRH1
artery morphogenesis (GO:0048844) 5.882CHD7, FGF8
positive regulation of transport (GO:0051050) 2.92KISS1, KISS1R
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62FEZF1, FGFR1
cellular component morphogenesis (GO:0032989) 3.52FGF8, SEMA3A
regulation of response to external stimulus (GO:0032101) 3.062FGFR1, SEMA3A
cellular response to organic substance (GO:0071310) 2.782GNRHR, NSMF
negative regulation of cell migration (GO:0030336) 4.412GNRH1, SEMA3A
positive regulation of muscle contraction (GO:0045933) 5.92TACR3, PROK2
C21-steroid hormone biosynthetic process (GO:0006700) 7.092LHB, FSHB
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352FEZF1, FSHB
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.552FEZF1, FGFR1
morphogenesis of a branching epithelium (GO:0061138) 4.772FGF8, FGFR1
positive regulation of organ growth (GO:0046622) 6.092FGF8, FGFR1
apoptotic process (GO:0006915) 3.142FGF8, SEMA3A
cation homeostasis (GO:0055080) 3.462KISS1, PROK2
negative regulation of RNA biosynthetic process (GO:1902679) 2.72FEZF1, FGFR1
embryonic hindlimb morphogenesis (GO:0035116) 6.362CHD7, FGF8
regulation of muscle system process (GO:0090257) 4.512TACR3, PROK2
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472FEZF1, FGFR1
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292FEZF1, FSHB
negative chemotaxis (GO:0050919) 6.042FLRT3, SEMA3A
neurogenesis (GO:0022008) 5.452FGF8, FGFR1
cellular hormone metabolic process (GO:0034754) 5.092LHB, FSHB
response to abiotic stimulus (GO:0009628) 2.82TACR3, NSMF
negative regulation of cellular component movement (GO:0051271) 4.222GNRH1, SEMA3A
generation of neurons (GO:0048699) 7.092FGF8, FGFR1
ketone biosynthetic process (GO:0042181) 6.552LHB, FSHB
cellular ketone metabolic process (GO:0042180) 5.542LHB, FSHB
regulation of cell cycle (GO:0051726) 2.932FGF8, FGFR1
regulation of cytosolic calcium ion concentration (GO:0051480) 4.412KISS1, PROK2
regulation of peptide secretion (GO:0002791) 4.382KISS1, CHD7
regulation of cell fate commitment (GO:0010453) 6.472FGFR1, DUSP6
regulation of cellular component biogenesis (GO:0044087) 3.082FLRT3, KISS1R
response to peptide (GO:1901652) 3.942GNRH1, GNRHR
regulation of organ morphogenesis (GO:2000027) 4.222FGF8, FGFR1
negative regulation of transcription, DNA-templated (GO:0045892) 2.752FEZF1, FGFR1
positive regulation of cellular component biogenesis (GO:0044089) 3.712FLRT3, KISS1R
cellular response to organonitrogen compound (GO:0071417) 3.872GNRHR, NSMF
positive regulation of transcription, DNA-templated (GO:0045893) 2.562FEZF1, FSHB

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of secretion (GO:0051046) -3.20.039FGF8, FSHB, DUSP6, GNRH1, CHD7, KISS1R, FGFR1, KISS1, SEMA3A, PROK2
signal transduction (GO:0007165) -1.280.015GNRHR, FGF17, FSHB, IL17RD, DUSP6, GNRH1, FGF8, KISS1R, FGFR1, TACR3, SEMA3A, FLRT3, LHB, PROKR2, PROK2, TAC3
axon guidance (GO:0007411) -4.440.001FEZF1, ANOS1, FSHB, DUSP6, SPRY4, SEMA3A, FGF8, FLRT3, HS6ST1, FGFR1
regulation of MAPK cascade (GO:0043408) -3.220.032PROK2, SPRY4, KISS1R, KISS1, FGFR1, DUSP6
regulation of neurogenesis (GO:0050767) -3.210.025FEZF1, GNRH1, NSMF, CHD7, SEMA3A, FGFR1
neuropeptide signaling pathway (GO:0007218) -5.130.011PROKR2, PROK2, TAC3, KISS1R
neuron projection guidance (GO:0097485) -4.430.001FEZF1, ANOS1, FSHB, FGFR1, SPRY4, SEMA3A, FGF8, FLRT3, HS6ST1, DUSP6
taxis (GO:0042330) -4.030.013ANOS1, FGFR1, GNRH1, FLRT3, FGF8, SEMA3A, PROK2
regulation of growth (GO:0040008) -3.260.002FSHB, GNRH1, SPRY4, FGF8, KISS1R, FGFR1, CHD7, SEMA3A, LHB, HS6ST1, DUSP6, PROK2
progesterone metabolic process (GO:0042448) -7.090.012LHB, GNRH1, FSHB
tachykinin receptor signaling pathway (GO:0007217) -7.780.036TACR3, TAC3
rhythmic process (GO:0048511) -4.020.046FSHB, GNRH1, KISS1, LHB, PROKR2, PROK2, GNRHR
genitalia development (GO:0048806) -6.20.008FGFR1, FGF8, GNRH1, CHD7
regulation of neuron migration (GO:2001222) -6.360.002FGFR1, GNRH1, NSMF, SEMA3A
positive regulation of neuron migration (GO:2001224) -7.330.027NSMF, SEMA3A
cellular response to endogenous stimulus (GO:0071495) -3.330.025FGF17, FSHB, DUSP6, GNRH1, KISS1, KISS1R, FGFR1, FGF8, NSMF, LHB, PROK2, GNRHR
progesterone biosynthetic process (GO:0006701) -7.940.027LHB, GNRH1, FSHB
C21-steroid hormone biosynthetic process (GO:0006700) -7.090.006LHB, GNRH1, FSHB
reproductive structure development (GO:0048608) -4.080.013FSHB, FGFR1, GNRH1, CHD7, FGF8, LHB, HS6ST1, DUSP6
chemotaxis (GO:0006935) -4.040.013ANOS1, FGFR1, GNRH1, FLRT3, FGF8, SEMA3A, PROK2
negative regulation of cardiac muscle tissue development (GO:0055026) NEW6.960.006FGF8, FGFR1
cellular response to stimulus (GO:0051716) -1.970.037IL17RD, FGFR1, FSHB, DUSP6, GNRH1, TACR3, KISS1R, TAC3, GNRHR, FGF8, NSMF, SEMA3A, FLRT3, LHB, PROKR2, PROK2, FGF17
reproductive process (GO:0022414) -2.550.028FSHB, GNRH1, FGF8, CHD7, LHB, HS6ST1, PROK2, TAC3
cellular response to hormone stimulus (GO:0032870) -3.990.004FSHB, DUSP6, GNRH1, NSMF, FGFR1, FGF8, FGF17, LHB, PROK2, GNRHR
regulation of hormone secretion (GO:0046883) -4.180.002FSHB, GNRH1, CHD7, FGF8, KISS1R, KISS1, FGFR1, DUSP6
regulation of cell fate specification (GO:0042659) -7.160.012FGFR1, FGF8, DUSP6
regulation of multicellular organismal process (GO:0051239) -1.870.002FEZF1, TACR3, FSHB, GNRH1, CHD7, FGF8, SEMA3A, FGFR1, KISS1, NSMF, DUSP6, PROK2
olfactory bulb development (GO:0021772) -6.680.001FEZF1, CHD7, SEMA3A
negative chemotaxis (GO:0050919) -6.040.039FGFR1, FLRT3, SEMA3A
response to chemical (GO:0042221) -1.980.004ANOS1, FGF8, FGF17, FSHB, DUSP6, GNRH1, TACR3, NSMF, FGFR1, CHD7, SEMA3A, FLRT3, PROK2, GNRHR
response to peptide hormone (GO:0043434) -4.060.048FSHB, PROK2, GNRH1, FGFR1, FGF8, FGF17, DUSP6, GNRHR
C21-steroid hormone metabolic process (GO:0008207) -6.550.039LHB, GNRH1, FSHB
locomotion (GO:0040011) -2.910.047FEZF1, ANOS1, FGFR1, FLRT3, FGF8, SEMA3A, PROK2
cellular response to gonadotropin-releasing hormone (GO:0097211) NEW7.650.042GNRH1, GNRHR
response to gonadotropin-releasing hormone (GO:0097210) NEW7.650.042GNRH1, GNRHR
response to hormone (GO:0009725) -3.330.028TACR3, FSHB, DUSP6, GNRH1, FGF8, NSMF, FGFR1, KISS1, GNRHR, LHB, PROK2, FGF17
response to stimulus (GO:0050896) -1.220.022ANOS1, TACR3, GNRHR, FGF17, FSHB, IL17RD, PROK2, GNRH1, FGF8, KISS1R, FGFR1, CHD7, NSMF, SEMA3A, FLRT3, LHB, PROKR2, DUSP6, TAC3
regulation of nervous system development (GO:0051960) -3.10.047FEZF1, GNRH1, NSMF, CHD7, SEMA3A, FGFR1
regulation of multicellular organismal development (GO:2000026) -2.310.016FEZF1, FSHB, FGFR1, GNRH1, FGF8, NSMF, CHD7, SEMA3A, DUSP6
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.1122IL17RD, FSHB, KISS1, SEMA3A, GNRHR, WDR11, SPRY4, FLRT3, DUSP6, ANOS1, NSMF, FGF8, PROKR2, FGF17, FEZF1, GNRH1, CHD7, KISS1R, TACR3, LHB, HS6ST1, FGFR1
intracellular part (GO:0044424) 0.2816FEZF1, TACR3, IL17RD, WDR11, FSHB, GNRH1, SPRY4, CHD7, KISS1R, FGFR1, KISS1, NSMF, FLRT3, LHB, HS6ST1, DUSP6
membrane part (GO:0044425) 0.9514TACR3, IL17RD, WDR11, GNRH1, SPRY4, FGF8, NSMF, KISS1, KISS1R, FLRT3, PROKR2, FGFR1, HS6ST1, GNRHR
membrane-bounded organelle (GO:0043227) 0.4714FEZF1, IL17RD, WDR11, FSHB, GNRH1, SPRY4, TACR3, KISS1R, CHD7, NSMF, FLRT3, LHB, FGFR1, TAC3
organelle (GO:0043226) 0.414FEZF1, IL17RD, WDR11, FSHB, GNRH1, SPRY4, TACR3, KISS1R, CHD7, NSMF, FLRT3, LHB, FGFR1, TAC3
membrane (GO:0016020) 0.6813ANOS1, IL17RD, WDR11, SPRY4, TACR3, NSMF, KISS1, KISS1R, FLRT3, PROKR2, FGFR1, HS6ST1, GNRHR
extracellular region (GO:0005576) 2.1812ANOS1, FGF17, FSHB, FGFR1, GNRH1, KISS1, SEMA3A, FGF8, FLRT3, LHB, PROK2, TAC3
plasma membrane part (GO:0044459) 1.9512TACR3, IL17RD, KISS1R, SPRY4, FGF8, NSMF, KISS1, FLRT3, PROKR2, FGFR1, HS6ST1, GNRHR
cytoplasmic part (GO:0044444) 0.8211IL17RD, WDR11, GNRH1, SPRY4, NSMF, FGFR1, KISS1, FLRT3, LHB, HS6ST1, DUSP6
intracellular organelle (GO:0043229) 0.5111FEZF1, IL17RD, WDR11, GNRH1, SPRY4, TACR3, NSMF, CHD7, KISS1R, FLRT3, FGFR1
intracellular membrane-bounded organelle (GO:0043231) 0.611FEZF1, IL17RD, GNRH1, WDR11, KISS1R, SPRY4, TACR3, NSMF, CHD7, FLRT3, FGFR1
cytoplasm (GO:0005737) 1.0110IL17RD, FSHB, WDR11, FGFR1, SPRY4, TACR3, NSMF, KISS1, FLRT3, DUSP6
extracellular region part (GO:0044421) 1.5710ANOS1, FSHB, GNRH1, FGF8, FLRT3, KISS1, SEMA3A, LHB, FGF17, TAC3
plasma membrane (GO:0005886) 1.3910ANOS1, IL17RD, SPRY4, NSMF, TACR3, KISS1R, FLRT3, PROKR2, FGFR1, GNRHR
intracellular organelle part (GO:0044446) 0.819IL17RD, WDR11, GNRH1, NSMF, CHD7, FLRT3, LHB, HS6ST1, DUSP6
integral component of membrane (GO:0016021) 1.149IL17RD, WDR11, FLRT3, TACR3, KISS1R, PROKR2, FGFR1, HS6ST1, GNRHR
intrinsic component of membrane (GO:0031224) 1.139IL17RD, WDR11, KISS1R, TACR3, FLRT3, PROKR2, FGFR1, HS6ST1, GNRHR
organelle part (GO:0044422) 0.799IL17RD, WDR11, GNRH1, NSMF, CHD7, FLRT3, LHB, HS6ST1, DUSP6
intrinsic component of plasma membrane (GO:0031226) 2.538IL17RD, FLRT3, TACR3, KISS1R, PROKR2, FGFR1, HS6ST1, GNRHR
extracellular space (GO:0005615) 2.638ANOS1, GNRH1, FGF8, SEMA3A, KISS1, FLRT3, FGF17, TAC3
integral component of plasma membrane (GO:0005887) 2.578IL17RD, FLRT3, TACR3, KISS1R, PROKR2, FGFR1, HS6ST1, GNRHR
neuron part (GO:0097458) 2.646GNRH1, KISS1, NSMF, TACR3, SEMA3A, FLRT3
nucleus (GO:0005634) 1.076FEZF1, WDR11, CHD7, NSMF, TACR3, FGFR1
cell projection (GO:0042995) 2.476SPRY4, GNRH1, NSMF, KISS1, SEMA3A, FLRT3
plasma membrane region (GO:0098590) 2.975KISS1, TACR3, SPRY4, FLRT3, NSMF
vesicle (GO:0031982) 1.645LHB, GNRH1, FGFR1, FSHB, TAC3
neuron projection (GO:0043005) 3.125KISS1, GNRH1, NSMF, SEMA3A, FLRT3
membrane-bounded vesicle (GO:0031988) 1.715LHB, GNRH1, FGFR1, TAC3, FSHB
Golgi apparatus part (GO:0044431) 3.04LHB, IL17RD, GNRH1, HS6ST1
cell projection part (GO:0044463) 2.974GNRH1, TACR3, SPRY4, FLRT3
nuclear part (GO:0044428) 1.554IL17RD, DUSP6, CHD7, NSMF
organelle membrane (GO:0031090) 1.974HS6ST1, IL17RD, WDR11, NSMF
extracellular organelle (GO:0043230) 1.893LHB, FSHB, TAC3
extracellular exosome (GO:0070062) 1.893LHB, FSHB, TAC3
intracellular non-membrane-bounded organelle (GO:0043232) 1.763CHD7, WDR11, NSMF
bounding membrane of organelle (GO:0098588) 2.393IL17RD, HS6ST1, WDR11
dendrite (GO:0030425) 3.923GNRH1, NSMF, SEMA3A
intracellular (GO:0005622) 2.373FGF8, FGF17, KISS1R
nucleoplasm (GO:0005654) 1.893IL17RD, DUSP6, NSMF
non-membrane-bounded organelle (GO:0043228) 1.763CHD7, WDR11, NSMF
extracellular vesicle (GO:1903561) 1.893LHB, FSHB, TAC3
cytosol (GO:0005829) 1.683FGFR1, KISS1, DUSP6
cell junction (GO:0030054) 2.753SPRY4, FLRT3, NSMF
extracellular matrix (GO:0031012) 3.812ANOS1, FLRT3
side of membrane (GO:0098552) 4.222FGF8, GNRH1
cell-substrate adherens junction (GO:0005924) 3.832SPRY4, FLRT3
focal adhesion (GO:0005925) 3.832SPRY4, FLRT3
cell-substrate junction (GO:0030055) 3.822SPRY4, FLRT3
synaptic membrane (GO:0097060) 4.222FLRT3, NSMF
neuron projection terminus (GO:0044306) 5.462GNRH1, FLRT3
axon terminus (GO:0043679) 5.682GNRH1, FLRT3
cytoplasmic, membrane-bounded vesicle (GO:0016023) 3.122GNRH1, FGFR1
cytoplasmic vesicle (GO:0031410) 2.872FGFR1, GNRH1
endoplasmic reticulum part (GO:0044432) 2.732GNRH1, FLRT3
synapse part (GO:0044456) 3.422FLRT3, NSMF
Golgi apparatus (GO:0005794) 2.72IL17RD, SPRY4
leading edge membrane (GO:0031256) 4.92TACR3, SPRY4
anchoring junction (GO:0070161) 3.612SPRY4, FLRT3
cell projection membrane (GO:0031253) 4.112TACR3, SPRY4
adherens junction (GO:0005912) 3.662SPRY4, FLRT3
axon (GO:0030424) 4.152FLRT3, SEMA3A
perikaryon (GO:0043204) 5.132GNRH1, NSMF
macromolecular complex (GO:0032991) 1.352FGFR1, NSMF
cytoskeleton (GO:0005856) 2.552WDR11, NSMF
Golgi membrane (GO:0000139) 3.282IL17RD, HS6ST1
axon part (GO:0033267) 4.42GNRH1, FLRT3
proteinaceous extracellular matrix (GO:0005578) 4.012ANOS1, FLRT3
intracellular vesicle (GO:0097708) 2.862FGFR1, GNRH1

NET-GE enrichment

Term New enriched termICP valueGenes
extracellular region (GO:0005576) -2.180.001FSHB, FGFR1, GNRH1, FGF8, SEMA3A, KISS1, FGF17, LHB, PROK2, TAC3
extracellular space (GO:0005615) -2.630.039ANOS1, GNRH1, KISS1, FLRT3, FGF8, FGF17, TAC3