Disease table of RHEUMATOID ARTHRITIS, SYSTEMIC JUVENILE OMIM ID: 604302

Gene-disease associations table

GeneAssociated with RHEUMATOID ARTHRITIS, SYSTEMIC JUVENILE inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
IL6OMIMHGNC link7p15.35108010, 148000, 604302, 125853, PS266600
MIFOMIMHGNC link22q11.231604302

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
NFKB1NO306NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC62IL6, MIF
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC12IL6, MIF
RELANO302NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC62IL6, MIF
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
IL6YES29OTX2, TBP, ATF4, DDIT3, JUND, REL, SP1, EGR1, EP300, KLF4, CREB1, ZMYND11, FOXO1, PPARA, XBP1, ZNF300, VDR, JUN, RELA, NFKB1, AHR, STAT1, STAT3, CEBPA, RBPJ, CEBPB, GBX2, MYC, ZFP360
MIFYES5SP1, HBP1, NFKB1, HIF1A, RELA0
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
IL6MIFNo-4UBC, IL17A, MMP9, TP53

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
IL6MIFmaybe, indirectThey may be in indirect interaction becasue they are both cytokine. [UniProt]
KEGG pathways annotation: NET-GE enrichment (no shared terms)

NET-GE enrichment

Term New enriched termICP valueGenes
Tyrosine metabolism (hsa00350) NEW7.640.009IL6, MIF
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cytokine receptor binding (GO:0005126) 4.142IL6, MIF
receptor binding (GO:0005102) 2.432IL6, MIF
cytokine activity (GO:0005125) 4.342IL6, MIF
binding (GO:0005488) 0.182IL6, MIF
protein binding (GO:0005515) 0.462IL6, MIF

NET-GE enrichment

Term New enriched termICP valueGenes
cytokine receptor binding (GO:0005126) -4.140.003IL6, MIF
chemoattractant activity (GO:0042056) NEW6.480.041IL6, MIF
cytokine activity (GO:0005125) -4.340.002IL6, MIF
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of cytokine secretion (GO:0050707) 4.742IL6, MIF
regulation of phosphate metabolic process (GO:0019220) 2.352IL6, MIF
regulation of primary metabolic process (GO:0080090) 1.082IL6, MIF
regulation of secretion (GO:0051046) 3.22IL6, MIF
positive regulation of secretion (GO:0051047) 3.852IL6, MIF
regulation of transport (GO:0051049) 2.242IL6, MIF
positive regulation of response to stimulus (GO:0048584) 2.182IL6, MIF
regulation of response to stimulus (GO:0048583) 1.542IL6, MIF
signal transduction (GO:0007165) 1.282IL6, MIF
cell surface receptor signaling pathway (GO:0007166) 2.092IL6, MIF
regulation of production of molecular mediator of immune response (GO:0002700) 5.12IL6, MIF
cellular component organization or biogenesis (GO:0071840) 1.222IL6, MIF
cellular response to stimulus (GO:0051716) 1.972IL6, MIF
negative regulation of macromolecule metabolic process (GO:0010605) 2.012IL6, MIF
regulation of metabolic process (GO:0019222) 1.022IL6, MIF
taxis (GO:0042330) 4.032IL6, MIF
regulation of signal transduction (GO:0009966) 1.842IL6, MIF
positive regulation of signal transduction (GO:0009967) 2.52IL6, MIF
regulation of leukocyte proliferation (GO:0070663) 4.42IL6, MIF
positive regulation of molecular function (GO:0044093) 2.232IL6, MIF
positive regulation of biological process (GO:0048518) 1.22IL6, MIF
negative regulation of biological process (GO:0048519) 1.332IL6, MIF
positive regulation of chemokine production (GO:0032722) 5.822IL6, MIF
regulation of cell proliferation (GO:0042127) 2.412IL6, MIF
chemotaxis (GO:0006935) 4.042IL6, MIF
positive regulation of transport (GO:0051050) 2.92IL6, MIF
regulation of macromolecule metabolic process (GO:0060255) 1.082IL6, MIF
negative regulation of cell death (GO:0060548) 2.952IL6, MIF
regulation of protein kinase activity (GO:0045859) 3.152IL6, MIF
regulation of cellular protein metabolic process (GO:0032268) 1.992IL6, MIF
regulation of phosphorylation (GO:0042325) 2.52IL6, MIF
positive regulation of phosphorylation (GO:0042327) 2.92IL6, MIF
regulation of biological quality (GO:0065008) 1.682IL6, MIF
cell motility (GO:0048870) 3.022IL6, MIF
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731) 4.622IL6, MIF
regulation of peptidyl-tyrosine phosphorylation (GO:0050730) 4.352IL6, MIF
immune system process (GO:0002376) 2.292IL6, MIF
cellular response to stress (GO:0033554) 2.512IL6, MIF
positive regulation of immune response (GO:0050778) 3.42IL6, MIF
positive regulation of production of molecular mediator of immune response (GO:0002702) 5.552IL6, MIF
negative regulation of metabolic process (GO:0009892) 1.932IL6, MIF
positive regulation of metabolic process (GO:0009893) 1.742IL6, MIF
regulation of chemokine production (GO:0032642) 5.542IL6, MIF
regulation of signaling (GO:0023051) 1.722IL6, MIF
movement of cell or subcellular component (GO:0006928) 2.612IL6, MIF
biological regulation (GO:0065007) 0.392IL6, MIF
positive regulation of mononuclear cell proliferation (GO:0032946) 4.842IL6, MIF
regulation of mononuclear cell proliferation (GO:0032944) 4.452IL6, MIF
positive regulation of protein transport (GO:0051222) 3.612IL6, MIF
regulation of protein transport (GO:0051223) 3.122IL6, MIF
regulation of apoptotic process (GO:0042981) 2.52IL6, MIF
regulation of biological process (GO:0050789) 0.452IL6, MIF
positive regulation of establishment of protein localization (GO:1904951) 3.492IL6, MIF
regulation of protein secretion (GO:0050708) 3.772IL6, MIF
regulation of kinase activity (GO:0043549) 3.072IL6, MIF
cellular component organization (GO:0016043) 1.242IL6, MIF
positive regulation of immune system process (GO:0002684) 2.962IL6, MIF
regulation of immune system process (GO:0002682) 2.52IL6, MIF
regulation of molecular function (GO:0065009) 1.782IL6, MIF
regulation of protein localization (GO:0032880) 2.882IL6, MIF
regulation of establishment of protein localization (GO:0070201) 3.022IL6, MIF
regulation of peptidyl-serine phosphorylation (GO:0033135) 4.982IL6, MIF
regulation of developmental process (GO:0050793) 2.12IL6, MIF
regulation of catalytic activity (GO:0050790) 1.972IL6, MIF
regulation of cellular process (GO:0050794) 0.52IL6, MIF
positive regulation of MAPK cascade (GO:0043410) 3.572IL6, MIF
response to stress (GO:0006950) 1.82IL6, MIF
regulation of multicellular organismal process (GO:0051239) 1.872IL6, MIF
immune response (GO:0006955) 2.862IL6, MIF
positive regulation of intracellular signal transduction (GO:1902533) 2.952IL6, MIF
regulation of intracellular signal transduction (GO:1902531) 2.312IL6, MIF
positive regulation of macromolecule metabolic process (GO:0010604) 1.812IL6, MIF
defense response (GO:0006952) 2.782IL6, MIF
positive regulation of protein secretion (GO:0050714) 4.392IL6, MIF
response to stimulus (GO:0050896) 1.222IL6, MIF
positive regulation of protein modification process (GO:0031401) 2.72IL6, MIF
regulation of transferase activity (GO:0051338) 2.882IL6, MIF
regulation of leukocyte activation (GO:0002694) 3.62IL6, MIF
regulation of immune effector process (GO:0002697) 3.712IL6, MIF
positive regulation of leukocyte activation (GO:0002696) 4.02IL6, MIF
cellular developmental process (GO:0048869) 1.822IL6, MIF
positive regulation of immune effector process (GO:0002699) 4.692IL6, MIF
positive regulation of multicellular organismal process (GO:0051240) 2.492IL6, MIF
inflammatory response (GO:0006954) 3.642IL6, MIF
positive regulation of response to external stimulus (GO:0032103) 4.172IL6, MIF
regulation of response to external stimulus (GO:0032101) 3.062IL6, MIF
positive regulation of signaling (GO:0023056) 2.412IL6, MIF
negative regulation of signaling (GO:0023057) 2.652IL6, MIF
regulation of phosphorus metabolic process (GO:0051174) 2.352IL6, MIF
regulation of secretion by cell (GO:1903530) 3.282IL6, MIF
positive regulation of secretion by cell (GO:1903532) 3.932IL6, MIF
positive regulation of cell communication (GO:0010647) 2.412IL6, MIF
regulation of cell communication (GO:0010646) 1.732IL6, MIF
single-organism process (GO:0044699) 0.482IL6, MIF
regulation of MAPK cascade (GO:0043408) 3.222IL6, MIF
negative regulation of protein metabolic process (GO:0051248) 2.822IL6, MIF
regulation of lymphocyte activation (GO:0051249) 3.732IL6, MIF
positive regulation of phosphorus metabolic process (GO:0010562) 2.782IL6, MIF
regulation of protein metabolic process (GO:0051246) 1.932IL6, MIF
positive regulation of protein metabolic process (GO:0051247) 2.432IL6, MIF
positive regulation of cellular protein metabolic process (GO:0032270) 2.492IL6, MIF
regulation of protein modification process (GO:0031399) 2.322IL6, MIF
positive regulation of cellular metabolic process (GO:0031325) 1.812IL6, MIF
positive regulation of cell proliferation (GO:0008284) 3.012IL6, MIF
cell proliferation (GO:0008283) 3.232IL6, MIF
cellular process (GO:0009987) 0.262IL6, MIF
positive regulation of B cell activation (GO:0050871) 5.272IL6, MIF
regulation of localization (GO:0032879) 1.942IL6, MIF
negative regulation of developmental process (GO:0051093) 3.172IL6, MIF
negative regulation of cellular protein metabolic process (GO:0032269) 2.882IL6, MIF
regulation of immune response (GO:0050776) 2.982IL6, MIF
aging (GO:0007568) 4.162IL6, MIF
positive regulation of lymphocyte activation (GO:0051251) 4.072IL6, MIF
regulation of lymphocyte proliferation (GO:0050670) 4.462IL6, MIF
positive regulation of lymphocyte proliferation (GO:0050671) 4.852IL6, MIF
regulation of cytokine production (GO:0001817) 3.42IL6, MIF
positive regulation of ERK1 and ERK2 cascade (GO:0070374) 4.562IL6, MIF
regulation of ERK1 and ERK2 cascade (GO:0070372) 4.232IL6, MIF
positive regulation of cytokine production (GO:0001819) 3.822IL6, MIF
developmental process (GO:0032502) 1.362IL6, MIF
positive regulation of peptidyl-serine phosphorylation (GO:0033138) 5.262IL6, MIF
regulation of cell activation (GO:0050865) 3.532IL6, MIF
regulation of B cell activation (GO:0050864) 4.922IL6, MIF
positive regulation of cell activation (GO:0050867) 3.972IL6, MIF
negative regulation of cellular metabolic process (GO:0031324) 2.012IL6, MIF
regulation of cellular metabolic process (GO:0031323) 1.072IL6, MIF
leukocyte migration (GO:0050900) 4.192IL6, MIF
cell migration (GO:0016477) 3.122IL6, MIF
regulation of cell death (GO:0010941) 2.432IL6, MIF
regulation of programmed cell death (GO:0043067) 2.492IL6, MIF
negative regulation of apoptotic process (GO:0043066) 3.042IL6, MIF
positive regulation of leukocyte proliferation (GO:0070665) 4.792IL6, MIF
negative regulation of programmed cell death (GO:0043069) 3.022IL6, MIF
regulation of gene expression (GO:0010468) 1.372IL6, MIF
positive regulation of phosphate metabolic process (GO:0045937) 2.782IL6, MIF
single-organism developmental process (GO:0044767) 1.492IL6, MIF
single-organism cellular process (GO:0044763) 0.652IL6, MIF
regulation of response to stress (GO:0080134) 2.532IL6, MIF
locomotion (GO:0040011) 2.912IL6, MIF
negative regulation of cell communication (GO:0010648) 2.662IL6, MIF
regulation of protein phosphorylation (GO:0001932) 2.572IL6, MIF
positive regulation of protein phosphorylation (GO:0001934) 2.952IL6, MIF
negative regulation of cellular process (GO:0048523) 1.412IL6, MIF
positive regulation of cellular process (GO:0048522) 1.32IL6, MIF

NET-GE enrichment

Term New enriched termICP valueGenes
positive regulation of peptidyl-serine phosphorylation (GO:0033138) -5.260.01IL6, MIF
regulation of chemokine production (GO:0032642) -5.540.006IL6, MIF
regulation of peptidyl-serine phosphorylation (GO:0033135) -4.980.017IL6, MIF
positive regulation of response to biotic stimulus (GO:0002833) NEW6.070.02IL6, MIF
positive regulation of mononuclear cell proliferation (GO:0032946) -4.840.025IL6, MIF
regulation of production of molecular mediator of immune response (GO:0002700) -5.10.011IL6, MIF
regulation of protein secretion (GO:0050708) -3.770.049IL6, MIF
fatty acid derivative biosynthetic process (GO:1901570) NEW9.040.041IL6, MIF
regulation of cytokine secretion (GO:0050707) -4.740.021IL6, MIF
positive regulation of leukocyte proliferation (GO:0070665) -4.790.027IL6, MIF
regulation of B cell activation (GO:0050864) -4.920.016IL6, MIF
positive regulation of chemokine production (GO:0032722) -5.820.002IL6, MIF
negative regulation of lymphocyte apoptotic process (GO:0070229) NEW6.430.024IL6, MIF
protein homotrimerization (GO:0070207) NEW6.730.007IL6, MIF
protein trimerization (GO:0070206) NEW6.040.04IL6, MIF
positive regulation of B cell proliferation (GO:0030890) NEW6.090.041IL6, MIF
positive regulation of B cell activation (GO:0050871) -5.270.006IL6, MIF
positive chemotaxis (GO:0050918) NEW6.170.044IL6, MIF
positive regulation of protein secretion (GO:0050714) -4.390.02IL6, MIF
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731) -4.620.035IL6, MIF
positive regulation of lipopolysaccharide-mediated signaling pathway (GO:0031666) NEW7.650.001IL6, MIF
positive regulation of lymphocyte proliferation (GO:0050671) -4.850.024IL6, MIF
regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664) NEW6.730.012IL6, MIF
icosanoid biosynthetic process (GO:0046456) NEW6.090.041IL6, MIF
regulation of macrophage activation (GO:0043030) NEW6.430.027IL6, MIF
positive regulation of ERK1 and ERK2 cascade (GO:0070374) -4.560.024IL6, MIF
regulation of ERK1 and ERK2 cascade (GO:0070372) -4.230.045IL6, MIF
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
cytoplasm (GO:0005737) 1.012IL6, MIF
extracellular space (GO:0005615) 2.632IL6, MIF
cell part (GO:0044464) 0.112IL6, MIF
extracellular region (GO:0005576) 2.182IL6, MIF
intracellular part (GO:0044424) 0.282IL6, MIF
extracellular region part (GO:0044421) 1.572IL6, MIF